Achaete-Scute Complex Genome Region: A genomic region found in DROSOPHILA. The region contains genes encoding BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS that play a critical role in the regulation of pattern formation during EMBRYONIC DEVELOPMENT.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Sense Organs: Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Genes, Insect: The functional hereditary units of INSECTS.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Nervous System: The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Chromosomes, Plant: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Contig Mapping: Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Genes, Plant: The functional hereditary units of PLANTS.Herpesvirus 1, Gallid: The type species of the genus ILTOVIRUS found on every continent and affecting mainly chickens and occasionally pheasants.Gene Components: The parts of the gene sequence that carry out the different functions of the GENES.Peripheral Nervous System: The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Helix-Loop-Helix Motifs: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Chromatin: The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Fagopyrum: A plant genus of the family POLYGONACEAE that is used as an EDIBLE GRAIN. Although the seeds are used as cereal, the plant is not one of the cereal grasses (POACEAE).Medical Staff: Professional medical personnel who provide care to patients in an organized facility, institution or agency.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Dermatoglyphics: The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Satiety Response: Behavioral response associated with the achieving of gratification.SOX Transcription Factors: A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.High Mobility Group Proteins: A family of low-molecular weight, non-histone proteins found in chromatin.Dosage Compensation, Genetic: Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Quantitative Trait, Heritable: A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)Crosses, Genetic: Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.Genes, myc: Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.Proto-Oncogene Proteins c-myc: Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.Oncogenes: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.3' Untranslated Regions: The sequence at the 3' end of messenger RNA that does not code for product. This region contains transcription and translation regulating sequences.Lung Neoplasms: Tumors or cancer of the LUNG.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian. (1/5)(+info)
Distribution and function of splash, an achaete-scute homolog in the adult olfactory organ of the Caribbean spiny lobster Panulirus argus. (2/5)(+info)
Expression of the active Notch1 decreases MTC tumor growth in vivo. (3/5)(+info)
Nematostella vectensis achaete-scute homolog NvashA regulates embryonic ectodermal neurogenesis and represents an ancient component of the metazoan neural specification pathway. (4/5)(+info)
BMP and Delta/Notch signaling control the development of amphioxus epidermal sensory neurons: insights into the evolution of the peripheral sensory system. (5/5)(+info)
The evolution of the nervous system in metazoan animals has been a topic of great interest. It is thought that the first nerve cell (neuron) evolved in a common ancestor of cnidarians and bilaterians, because neuronal cell types are absent in their sister group, the sponges (Galliot et al., 2009). Although putative sensory cells do exist in the sponge, these cells do not form synapses and do not possess dendrites and axons (Richards et al., 2008). Although cnidarians typically have a diffuse nerve net, some regionalization patterns of neurons and their neurites have been identified in several types of cnidarians (Galliot et al., 2009; Watanabe et al., 2009). It is possible that these cnidarian nerve rings might represent a primitive organized nervous system. After the divergence of cnidarians and bilaterians, a centralized nervous system evolved in the bilaterian lineage (Arendt et al., 2008; Holland, 2003). The evolutionary origin of the central nervous system (CNS) in bilaterian animals has ...
THE wing surface of lepidopteran adults is covered by wing scales, which function in heat preservation, mimesis, touch, etc. (Nijhout 1991). Lepidopteran scales and Drosophila bristles are considered homologous structures on the basis of the similarities in their cell lineages and the expression of a few molecular markers (Overton 1966, 1967; Galant et al. 1998). Development of the Drosophila bristle is regulated by the basic helix-loop-helix (bHLH) transcription factors of the Achaete-Scute Complex (AS-C). Within the clusters of cells expressing achaete (ac) and scute (sc), some are selected to become sensory organ precursors, which then form and innervate the mature bristles (Skeath and Carroll 1991; Jan and Jan 1994). In ac/sc double-mutant flies, the majority of the bristles are lost; on the contrary, ectopic expression of ac and/or sc can induce extra bristles (Garcia-Bellido 1979; Campuzano et al. 1986; Balcells et al. 1988; Rodriguez et al. 1990). In the butterfly Precis coenia, the AS-C ...
Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008 ...
Our Salad Splashes are naturally fresh and light with just a hint of oil. They are all natural and are made with only the finest high quality ingredients. There is so much flavor that just a splash will do. Splashes are naturally fresh and light. Use just a dash of splash to freshen a salad. Just a little bit of Splash on a salad makes magic. But you can do so much more with our Splashes. You can sauté vegetables, marinate chicken, drizzle over a cold pasta salad or use it a dip for appetizers. Splash your imagination and watch your cooking come alive.. ...
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You all probably know these images that are shown on starting up a certain program: these are so called splash screens. In this tutorial I will show you how to make a special, very beautiful splash...
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This is how I add a Splash Screen in my Xamarin Forms apps Create a new ContentPage ie Splash.xaml Set…. Continue Reading →. ...
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ABSTRACT: Panulirus argus virus 1 (PaV1) is an unclassified, pathogenic virus first discovered in Caribbean spiny lobsters Panulirus argus from the Florida Keys, USA, and has since been confirmed in lobsters in other parts of the Caribbean. Several studies have examined the prevalence, pathogenicity, and population dynamics of the pathogen in the lobster host, but little is known about the genetic diversity of the virus. We analyzed a fragment of viral DNA from lobsters collected in the Florida Keys, which provided the first insight into the genetic diversity of PaV1. The variation in viral sequences, both within and between individual lobsters, indicates that lobsters can be infected with multiple viral strains. Laboratory experiments in which uninfected lobsters were serially exposed to lobsters inoculated with PaV1 implied that rapid mutation of strains is unlikely and suggest that there may be endemic strains of PaV1. In addition, we discovered PaV1 in P. argus postlarvae (pueruli), ...
The Caribbean spiny lobster Panulirus argus is under threat from a deadly virus. Panulirus argus 1 (PaV1) is found throughout the Caribbean, infecting up to 30% of lobsters in some areas.
We have isolated a novel Xenopus homolog of the Drosophila achaete-scute genes, called XASH-3. XASH-3 expression is neural specific and is detected as early as stage 11 1/2, making it one of the earliest markers of neural induction so far described. Moreover, XASH-3 expression within the neural plate is regionally restricted. Transverse bands of XASH-3 mRNA mark discrete positions along the anteroposterior axis, while longitudinal bands mark a discrete position along the mediolateral axis. This latter site of XASH-3 expression appears to demarcate the prospective sulcus limitans, a boundary zone that later separates the functionally distinct dorsal (alar) and ventral (basal) regions of the spinal cord. In sandwich explants lacking any underlying mesoderm, XASH-3 is expressed in longitudinal stripes located lateral to the midline. This provides the first indication that planar or midline-derived inductive signals are sufficient to establish at least some aspects of positional identity along the ...
Human sensory and motor systems provide the natural means for the exchange of information between individuals, and, hence, the basis for human civilization. The recent development of brain-computer interfaces (BCI) has provided an important element for the creation of brain-to-brain communication systems, and precise brain stimulation techniques are now available for the realization of non-invasive computer-brain interfaces (CBI). These technologies, BCI and CBI, can be combined to realize the vision of non-invasive, computer-mediated brain-to-brain (B2B) communication between subjects (hyperinteraction). Here we demonstrate the conscious transmission of information between human brains through the intact scalp and without intervention of motor or peripheral sensory systems. Pseudo-random binary streams encoding words were transmitted between the minds of emitter and receiver subjects separated by great distances, representing the realization of the first human brain-to-brain interface. In a series of
TY - JOUR. T1 - Chronic neuropathic pain. T2 - Pathomechanism and pharmacology. AU - Urban, L.. AU - Nagy, I.. AU - Bevan, S. J.. PY - 2002. Y1 - 2002. N2 - Neuropathic pain syndromes form a group of loosely connected diseases linked by the common presence of injury/damage to the peripheral sensory system and the resulting effect: chronic pain. Treatment of patients suffering from neuropathic pain is one of the most challenging clinical tasks as classical painkillers such as opioids and nonsteroidal anti-inflammatory drugs lack antinociceptive effect in these syndromes. The recent development of various animal models aided our understanding of neuropathic pain and provided targets for analgesic intervention. The discovery of abnormal, ectopic activity in injured primary afferents, sprouting of large calibre primary afferent fibres to the superficial dorsal horn, and changes in protein expression in DRG (dorsal root ganglion) cells after injury has highlighted differences between the ...
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The purpose of this document is to provide direction to owners and operators of spray/ splash pads concerning the construction, operation, safety and maintenance of these facilities located within the Niagara region.. There are several risks associated with the use of spray/splash pads. These risks include injuries related to the physical structure and operation of the facility, as well as the risk of waterborne illnesses from exposure to contaminated water.. To reduce the risk of injury, illness or death to facility patrons, it is imperative that the owner/operator of a non-regulated recreational water facility construct, operate, and maintain the facility in a safe manner in accordance with applicable legislation and guidance material, including this document.. ...
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mouse Ascl2 protein: mammalian homolog of the Drosophila achaete-scute complex; expressed in neuronal precursors; RefSeq NM_008554
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Most show cars make a big splash on their introduction, maybe tour the country or a few different countries for a year or so, then descend into warehouse purgat
Echograph is the intersection of photography and video. Insert splashes of video into still photos. Explore this new creative medium that merges video with photos. | Reflections from a Life Lived
Splash Potions break when thrown and cover players/mobs with there contents. Regeneration Splash Potions will increases the regeneration rate of anything they cover ...
AGBENIGA, B. e WEBB, E.C.. Effect of slaughter technique on bleed-out, blood in the trachea and blood splash in the lungs of cattle. S. Afr. j. anim. sci. [online]. 2012, vol.42, n.5, pp.524-529. ISSN 2221-4062.. The South African Animal Protection Law, which requires animals to be stunned before slaughter, allows certain exemptions to accommodate religious slaughter. The supporters of the Jewish method of slaughter (Shechita), in which animals are slaughtered without pre-stunning, claim that the bleed-out and some quality parameters are better than when the animals are stunned before slaughtering. In this study, the percentage blood loss (BL%), presence (%) of blood in the trachea (BLT%) and blood splash % in the lungs (BS%), between the Shechita (Kosher) group and the conventionally slaughtered group of cattle were compared. Results showed no significant difference between the two treatment groups in terms of blood loss, although the conventional group had a higher bleed-out. However, there ...
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The formation of neuroblasts depends on the Achaete-scute complex genes - achaete (ac), scute (sc), lethal of scute (lsc) and ... The helixes mediate dimerization, and the adjacent basic region is required for DNA binding. The human genome contains ... Members of achaete-scute complex, such as achaete and scute, as well as ''atonal'' and ''daughterless'' confer to ectodermal ... Later on, in the 1970s, the achaete-scute complex, a complex of genes that are involved in regulating the early steps of neural ...
Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene. This gene is a member of the ... Human ASCL2 genome location and ASCL2 gene details page in the UCSC Genome Browser. Miyamoto T, Jinno Y, Sasaki T, Ikeda Y, ... gene region". Journal of Human Genetics. 43 (1): 69-70. doi:10.1007/s100380050041. PMID 9610003. Onions J, Hermann S, ... ASCL2 achaete-scute complex homolog 2 (Drosophila)". Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, ...
... the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1. This gene encodes a member of ... Human ASCL1 genome location and ASCL1 gene details page in the UCSC Genome Browser. This article incorporates text from the ... transcriptional regulation by dual inhibitory regions". Cell Growth & Differentiation. 8 (6): 677-86. PMID 9186001. Lo L, ... "Entrez Gene: ASCL1 achaete-scute complex homolog 1 (Drosophila)". Sanes, Dan Harvey (2011). The development of the nervous ...
"Translational Regulation of the Human Achaete-scute Homologue-1 by Fragile X Mental Retardation Protein". Journal of Biological ... These telomeric regions are characterized by long regions of double-stranded CCCTAA:TTAGGG repeats. The repeats end with a 3' ... "Genome-wide prediction of G4 DNA as regulatory motifs: Role in Escherichia coli global regulation". Genome Research. 16 (5): ... The heterodimeric complex ribonucleoprotein enzyme telomerase adds TTAGGG repeats at the 3' end of DNA strands. At these 3' end ...
There are up to 2600 TFs in the human genome. TFs work alone or with other proteins in a complex, by promoting (as an activator ... Achaete-Scute 1.2.4 Family: Tal/Twist/Atonal/Hen 1.3 Class: Helix-loop-helix / leucine zipper factors (bHLH-ZIP) 1.3.1 Family: ... The preinitiation complex binds to promoter regions of DNA upstream to the gene that they regulate. Other transcription factors ... The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more ...
The preinitiation complex binds to promoter regions of DNA upstream to the gene that they regulate. ... 1.2.3 Family: Achaete-Scute. *1.2.4 Family: Tal/Twist/Atonal/Hen ... Thus, given the genome sequence it is still difficult to ... "Genome Informatics. International Conference on Genome Informatics. 15 (2): 276-86. PMID 15706513. Archived from the original ... The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more ...
It is suspected C21orf59 is found in the brain early in development due to the two achaete-scute complex homologue ... transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746-59. ... Human C21orf59 genome location and C21orf59 gene details page in the UCSC Genome Browser. Denoeud F, Kapranov P, Ucla C, et al ... The C21orf59 gene lies within the critical region of Down Syndrome. There are no clear paralogs in humans, but the gene has ...
Chen H, Kunnimalaiyaan M, Van Gompel JJ (2006). "Medullary thyroid cancer: the functions of raf-1 and human achaete-scute ... enabling complex movements and profound conformational rearrangements within the molecule. This hinge region contains a small, ... Human RAF1 genome location and RAF1 gene details page in the UCSC Genome Browser. Molecular and Cellular Biology portal. ... Historically, this autoinhibitory block was labelled as the CR1 region ("Conserved Region 1"), the hinge region being named CR2 ...
The formation of neuroblasts depends on the Achaete-scute complex genes - achaete (ac), scute (sc), lethal of scute (lsc) and ... The helixes mediate dimerization, and the adjacent basic region is required for DNA binding. The human genome contains ... Members of achaete-scute complex, such as achaete and scute, as well as atonal and daughterless confer to ectodermal ... Later on, in the 1970s, the achaete-scute complex, a complex of genes that are involved in regulating the early steps of neural ...
Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene. This gene is a member of the ... Human ASCL2 genome location and ASCL2 gene details page in the UCSC Genome Browser. Miyamoto T, Jinno Y, Sasaki T, Ikeda Y, ... gene region". Journal of Human Genetics. 43 (1): 69-70. doi:10.1007/s100380050041. PMID 9610003. Onions J, Hermann S, ... ASCL2 achaete-scute complex homolog 2 (Drosophila)". Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, ...
The other copy located in D. virilis is present within the enhancer region of the achaete-scute (ac-sc) complex (Accession No. ... Coding regions constitute a small portion of metazoan genomes, representing ~24% of the small genome of Drosophila melanogaster ... Finishing a whole-genome shotgun: Release 3 of the Drosophila melanogaster euchromatic genome sequence. Genome Biol. 2002, 3: ... This led to the identification of the 25-30 bp motif in many regions of the fly genome (more than 300 hits). This motif does ...
1990) Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster. Neuron 5, ... 1979) A region of the Drosophila genome necessary for CNS development. Nature 282, 310-312. ... 1990) Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta. ...
... bHLH activators encoded by the achaete-scute complex. Enriched bins (purity ≥50%, P , 0.005) from the proneural activator ... 0 regions of the cluster matrix. This highly unusual genome segment, which we call the A Lot of Su(H) Sites (ALS) region, ... However, these techniques address only part of the informational content of the genome. The complex blueprint that controls the ... The first bin in the matrix where each region was found is marked in Fig. 2; the specifications of each region, including the ...
Achaete-Scute Complex Genome Region * Stomach Neoplasms * Integrins * Neoplasm Metastasis * sesamin * thrombospondin 2 ...
Achaete-Scute Complex Genome Region. *Locus Control Region. *Major Histocompatibility Complex. *Minor Histocompatibility Loci ... Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates ... Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies. PLoS One. 2018; 13( ...
Notably, a neural reprogramming factor, ASCL1 (achaete-scute complex-like 1), was highly induced by EWS-WT1 in MEFs and in ... INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v15] ... Further analysis demonstrated that EWS-WT1 directly binds to the proximal promoter region of ASCL1 and activates its ... Here we identify FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (NPCs). Interestingly, ...
... achaete scute complex like 1, MIM 100790), which play a role in axon guidance and neuronal commitment and differentiation, ... which corresponds to a 8.7 Mb region (UCSC genome browser). ... Other candidate genes in this region are VGLUT3 (vesicular ... An autosomal dominant pattern of inheritance with reduced disease penetrance of 80% was seen.22 Before the genome screen, we ... This mapped the disease gene for familial temporal lobe epilepsy and febrile seizures to a 10.35 cM region between markers ...
Most of the achaete-scute complex of the fly Calliphora vicina (including the genes achaete, scute and lethal of scute) have ... This study demonstrates genome-wide and physical association between Nup98 and histone-modifying complexes MBD-R2/NSL and Trx/ ... Copper was found to be concentrated in the copper cell region but also in the region directly anterior to the copper cells and ... The achaete-scute complex has been a useful paradigm for the study of pattern formation and its evolution. achaete-scute genes ...
Using a combination of genome-wide binding analysis and gene expression profiling, we show that SoxNeuro directs embryonic ... D) SoxN and Dichaete common binding across the achaete-scute complex. (E) SoxN unique binding in proximity of robo3. (F) ... The genome-wide binding profiles of SoxN and Dichaete in wild-type embryos showed extensive overlap (2,893 regions, 1,890 genes ... including the proneural genes of the achaete-scute complex, the DV patterning TFs encoded by Dr and vnd, and the NB temporal ...
Achaete-Scute-Complex and Snail transcription factors, Prospero, Elav). We then performed in situ hybridization on embryos and ... with changes only around the control region. However, the genome of G. ovalis is very different from that of non-cymothoidan ... We conducted genome survey of Chthamalus challengeri as a preceding step to obtain genetic information through whole genome ... We conducted genome survey of Chthamalus challengeri as a preceding step to obtain genetic information through whole genome ...
Molecular and phenotypic variation in the achaete‐scute region of Drosophila melanogaster ... Complex modular cis ‐acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5 ... The role of the genome project in determining gene function: insights from model organisms ... Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily ...
Mackay and Langley (1990) and Lai and colleagues (1994) have shown that normal allelic variants at the achaete-scute complex ... At this point we have excluded most region of the genome as harboring a QTL and have narrowed our search to several candidate ... Mackay TFC, Langley CH (1990) Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster. Nature ... achaete-scute complex (T1a, T2-T5) control the relative abundance of different classes of neurons. Homologs of several of these ...
1989 Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster. Genetics 122: 607- ... and the achaete-scute complex (Longet al. 2000), was indeed associated with naturally occurring phenotypic variation in bristle ... Position 1 of the alignment corresponds to position 8,591,371 of the 3L sequence of Berkeley Drosophila Genome Project genome ... homozygous h region NIL; (iii) h region NIL as heterozygotes against Sam; h1 (BC20); (iv) h region NIL as heterozygotes against ...
We can ask whether or not such complexes are conserved in D. repleta. The achaete-scute complex (AS-C) has been studied ... When the physical maps of this region are compared, only a segment of ~130 kb, which includes the genes achaete and scute, has ... 1998 The achaete-scute complex as an integrating device. Int. J. Dev. Biol. 42: 275-282. ... This DNA contains many cis-regulatory sequences that coregulate the achaete and scute (but not the lethal-of-scute and asense) ...
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res 2009;69:845- ... A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. ... UTR of mammalian Achaete-Scute Complex homolog 1 (MASH1 or ASCL1), were finally selected. Genomic DNA isolated from peripheral ... UTR of the L-MYC gene MYCL1 and the neuronal development Achaete-Scute Complex homolog ASCL1. Case-control analyses showed that ...
Some of these QTLs are now known to correspond to key proneural and neurogenic genes, includingachaete-scute, atonal, enhancer ... Nnc1 maps between Hoxb and Krt1(Watkins-Chow et al., 1996). This region contains three strong candidates for Nnc1: Rara, Thra, ... A genome-wide search using simple and composite interval-mapping techniques revealed a major QTL on chromosome (Chr) 11 in a 3 ... Genetic variation in complex traits is thought to be generated by large numbers of loci that usually have comparatively small ...
Using in situ gene expression data for more than half of the Drosophila genome, we find that genes in these conserved clusters ... Most genes arise by duplication and move along the genome by random shuffling of DNA segments. Higher order structuring of the ... Our results highlight the association between genome architecture and the gene regulatory networks involved in the construction ... genome occurs in eukaryotes, where groups of physically linked genes are co-expressed. However, the contribution of gene ...
Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly ... This is partially due to the ability to analyze cancer genomes on a whole genome basis. Recently, a tool called array ... Olfactory neuroblastoma and other round cell lesions of the sinonasal region. Mod Pathol. 1996 Jun. 9(6):658-63. [Medline]. ... Due to the rare and complex nature of ENB, multiple opinions exist regarding the etiology, optimal staging system, and ...
Heitzler P, Bourouis M, Ruel L, Carteret C, Simpson P: Genes of the Enhancer of split and Achaete-Scute complexes are required ... maritima genome only one ASH homologue was identified; a second gene analyzed was too divergent in the basic region of the bHLH ... Skaer N, Pistillo D, Gibert J, Lio P, Wülbeck C, Simpson P: Gene duplication at the achaete-scute complex and morphological ... Dominguez M, Campuzano S: asense, a member of the Drosophila Achaete-Scute complex, is a proneural and neural differentiation ...
These include an achaete-scute homologue (ID: 106438), also known as NvashB, which functions in proneural patterning in other ... vectensis genome), 18S (GenBank: AF254382.1) and the mitochondrial genome (including 16S and 12S; GenBank: DQ643835.1). 762 ... However, these data suggest that the Smg CCR4/NOT transcription complex pathway for degradation of maternal RNAs may be present ... and decrease formation of posterior body regions . While multiple N. vectensis wnts have been studied with in situ ...
Binding of RMST to Sox2 promoted Sox2 binding at the promoters of neurogenic genes, such as achaete-scute homolog 1 (ASCL1 [102 ... complexes. Such lncRNA-RNP complexes can either affect histone modifications or stabilize signaling complexes or nuclear ... They found that Gomafu shares homologous region with RNCR2 and that human homologous sequence was located in a syntenic region ... J. L. Rinn and H. Y. Chang, "Genome regulation by long noncoding RNAs," Annual Review of Biochemistry, vol. 81, pp. 145-166, ...
Author Summary Parthenogenetic mouse embryos with two maternal genomes die early in development due to the misexpression of ... Also, it has been suggested that excess expression of the achaete-scute complex homolog 2 (Drosophila) (Ascl2) gene could ... Luedi PP, Hartemink AJ, Jirtle RL (2005) Genome-wide prediction of imprinted murine genes. Genome Res 15: 875-884. * View ... probably attributable to the distal region . Second, knockouts of imprinted genes and imprinting control regions (ICRs) ...
Proteins of the achaete-scute family of transcription factors play important roles in neurogenesis in both invertebrates and ... GlnBP-Gln complex has been proposed based on the crystal structures of the histidine-binding protein-His complex and "open form ... particularly in the perinuclear region. We have further defined a minimal interaction region of HHARI comprising residues 186- ... The genomes of vertebrates and cephalochordates contain only a single whn-like gene, suggesting that the primordial whn gene ...
GenesDrosophilaHomologHuman Achaete-Scute homologueASCL1BHLHTranscription factorLociAscl2ProneuralProteinsMetazoan genomesEukaryotic genomesChromosomeTranscriptionalChromosomalMelanogasterNeuronalGeneticsMicroarray analysisLocusMouse genomeDraft genomeLethalMRNATraitsLocalizationNeuronsMutationsNotchBiologyNeurogenicPhenotypeEmbryosSitu hybridizationSequencesGeneticChromatinFetalCancer GenomWhole-genome sPolymorphismVariationNeuralPopulationsRegulatoryOrganismParalogousGWASPromoterSubunitDevelopmentDiscreteHistoneTranscriptome
- Later on, in the 1970s, the achaete-scute complex, a complex of genes that are involved in regulating the early steps of neural development in Drosophila, were identified[by whom? (wikipedia.org)
- Using molecular tools it was possible to isolate the first four genes of this complex: achaete (ac), scute (sc), lethal of scute (lsc) and asense (ase). (wikipedia.org)
- and two ato-related genes, amos and cato, were later-isolated, defining a second family of proneural genes - atonal complex. (wikipedia.org)
- We have identified a 27 bp cis -regulatory sequence widely distributed within the Drosophila genome in association with developmental genes. (biomedcentral.com)
- While searching the D. melanogaster wg intron sequences for putative regulatory regions using an evolutionary comparative approach, we identified a 27 bp long motif that is overrepresented within the D. melanogaster genome and that is strongly associated with genes involved in development and/or signal transduction. (biomedcentral.com)
- Computational methods for predicting novel protein coding genes in whole-genome sequence data are quite advanced, and various strategies for recognizing transcription units that generate noncoding RNAs are also available. (pnas.org)
- The chromosomal regions that harbor genes that control this variation are being identified using recombinant inbred strains and intercross-backcross progeny. (nervenet.org)
- In genetic model organisms in which controlled crosses can be made and mutations at positional candidate genes generated, quantitative complementation tests of QTL alleles to mutant and wild-type alleles of candidate genes in the QTL region can narrow the number of positional candidate genes targeted for such association studies ( M ackay 2001 ). (genetics.org)
- In this study, we took an in silico approach to identify single-nucleotide polymorphisms (SNP) within the 3′-untranslated region (UTR) of miRNA genes deregulated in human small-cell lung cancer (SCLC), and then investigated their associations with SCLC susceptibility in 666 SCLC patients and 758 controls. (aacrjournals.org)
- MicroRNAs (miRNA) are a class of small, noncoding RNA molecules that regulate gene expression through binding the 3′-untranslated region (3′-UTR) of mRNAs of their target genes, resulting in mRNA cleavage or translation repression ( 13 ). (aacrjournals.org)
- Three strong candidate genes have been mapped previously to the same region as Nnc1 . (jneurosci.org)
- Some of these QTLs are now known to correspond to key proneural and neurogenic genes, including achaete-scute , atonal , enhancer of split , hairy , Notch , and scabrous ( Mackay, 1995 ). (jneurosci.org)
- The physical organization and chromosomal localization of genes within genomes is known to play an important role in their function. (biomedcentral.com)
- Most genes arise by duplication and move along the genome by random shuffling of DNA segments. (biomedcentral.com)
- Higher order structuring of the genome occurs in eukaryotes, where groups of physically linked genes are co-expressed. (biomedcentral.com)
- Using in situ gene expression data for more than half of the Drosophila genome, we find that genes in these conserved clusters are co-expressed to a much higher extent than other duplicated genes. (biomedcentral.com)
- The simple idea that the functionality of eukaryotic genomes is determined solely by the content of genes and their regulatory regions has been gradually replaced by a more complex view, which recognizes a crucial role for the way in which these functional elements are distributed and organized. (biomedcentral.com)
- The identification of substantial overlap in the expression patterns between genes within these groups suggests that these arrangements might be first fixed and subsequently maintained by the need for certain shared regulatory regions. (biomedcentral.com)
- In contrast to prokaryotes, where functionally related and co-expressed neighboring genes (mostly arranged in operons) are abundant and easily identified, eukaryotic genomes present an apparently much more complex organization, in which genes with no obviously ordered distribution predominate and co-exist with a smaller class of clustered, co-expressed genes. (biomedcentral.com)
- In fact, the identification of these clusters of duplicated genes underlines the importance of gene organization in eukaryotic genomes [ 8 ], and provides important information about how genes evolve after their duplication. (biomedcentral.com)
- The activity of genes of the achaete-scute ( ac-sc ) family endows cells with neural potential. (beds.ac.uk)
- Proneural genes are conserved throughout the animal kingdom and fall into two main classes: the achaete-scute ( ac-sc ) and atonal ( ato ) gene families. (beds.ac.uk)
- The D. melanogaster ac-sc gene complex (AS-C) comprises four genes, three of which are required for bristle development. (beds.ac.uk)
- Parthenogenetic mouse embryos with two maternal genomes die early in development due to the misexpression of imprinted genes. (plos.org)
- Parthenogenones possess two maternally-derived genomes and would be expected to possess abnormal levels of transcript of all known imprinted genes, that is, lack of expression of paternally expressed genes (two inactive copies), and over-expression of maternally expressed genes (two active copies). (plos.org)
- Bristle development is dependent on the activity of basic Helix-Loop-Helix transcription factors encoded by the achaete ( ac ) and scute ( sc ) genes. (sdbonline.org)
- The data obtained suggested that EAST protein belonged to a new regulatory system, which was common to most of the genes, and repressed transcription of the genes located in the euchromatin regions of the chromosomes. (deepdyve.com)
- TFs work alone or with other proteins in a complex, by promoting (as an activator ), or blocking (as a repressor ) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes. (wikipedia.org)
- Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins. (wikipedia.org)
- Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. (wikipedia.org)
- We take here an unbiased, genome-wide approach to identify genes that may act at any stage to ensure the correct differentiation of ASEL. (prolekarniky.cz)
- Screening a genome-wide RNAi library that knocks-down 18,179 genes (94% of the genome), we identified 245 genes that affect the development of the ASEL neuron, such that the neuron is either not generated, its fate is converted to that of another cell, or cells from other lineage branches now adopt ASEL fate. (prolekarniky.cz)
- Wang, and A. Delta 19-12 DrosophilageneticistsoftencallNotchaneurogenic gene and the achaete-scute genes proneural. (retzepti.ru)
- We show that the extreme Hw49c allele contains an inversion with a breakpoint within the AS-C, while the weak Hw685 allele is associated with a terminal deletion of the X chromosome which removes the achaete region of the AS-C. In both cases, foreign DNA in contact with the breakpoints presumably enhances expression of AS-C genes. (nih.gov)
- Overexpression of achaete (T5) or scute alpha (T4) genes was previously found in Hw mutants associated with insertions of transposable elements (Hw1, HwBS and HwUa, Campuzano et al. (nih.gov)
- Here, we demonstrate that Syn and dlg1 are direct target genes of Da in adult Drosophila heads, as Da binds to the regulatory regions of these genes and the modulation of Da levels alter the levels of Syn and dlg1 mRNA. (biologists.org)
- Successful implication of allelic and nucleotide variation in candidate genes in the production of phenotypic variation is aided by low amounts of LD, due to substantial historical recombination, in the fly genome. (biomedcentral.com)
- The genes that are not expressed are frequently in an 'inactive' region of the chromatin. (psu.edu)
- Although in many cases they do so by modifying a homologous structure with a different (or no) Hox input, there are also examples of Hox genes constructing new organs with no homology in other regions of the body. (hindawi.com)
- In the mouse there are four complexes including the paralogous Hox genes 1 to 13, to a total of 39, although no single complex has the whole repertoire of Hox genes [ 11 - 13 ]. (hindawi.com)
- In vertebrates, there is also a temporal sequence of activation of Hox genes, so that 5′ genes are expressed later and more posteriorly in the A/P axis, whereas those located at the other end of the complex are expressed earlier and more anteriorly [ 18 , 19 ]. (hindawi.com)
- My thesis aims to gain insights into the genes regulating NPC proliferation using a phenotypic-driven, genome-wide approach. (ubc.ca)
- Cdk inhibitor genes p21 and p27 transcript levels are increased and associated with elevated H3K9 acetylation levels at proximal promoter regions of p21 and p27 . (beds.ac.uk)
- To find genes whose inactivation is synthetically lethal to MYCN, we implemented a genome-wide approach in which we carried out a drop-out shRNA screen using a whole genome library that was delivered into isogenic neuroblastoma cell lines expressing or not expressing MYCN. (cancer-genetics.org)
- A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. (diva-portal.org)
- In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. (diva-portal.org)
- MiRNAs are small non-coding RNAs, about 18-24 nucleotides in length that control various biological processes through binding to the 3' untranslated region (UTR) of mRNAs, and affecting the stability and translation of their target genes. (jcancer.org)
- Finally, we used a genome-wide microarray to identify additional patterning genes downstream of MAPK that might contribute to neurogenesis. (biomedcentral.com)
- The neurogenic Drosophila bHLH proteins are encoded by an 100-kb stretch of genomic DNA, termed the achaete- scute complex (AS-C), containing four genes designated achaete (ac), scute (sc), lethal of scute (lsc), and asense (a). (forexonline-ar.com)
- Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene. (wikipedia.org)
- This motif may be very useful towards the annotation of functional regulatory regions within the Drosophila genome and the construction of regulatory networks of Drosophila development. (biomedcentral.com)
- We have carried out a Drosophila genomewide inventory of predicted binding sites for the Notch-regulated transcription factor Suppressor of Hairless [Su(H)] and found that the fly genome contains highly nonrandom clusterings of Su(H) sites over a broad range of sequence intervals. (pnas.org)
- Perl scripts (available on request) were written to search the Drosophila genome for matches to binding site consensus sequences. (pnas.org)
- Release 2 (October, 2000) chromosome arm sequences and gene annotation data were downloaded from the Berkeley Drosophila Genome Project web site ( http://www.bdgp.org ). (pnas.org)
- Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster. (google.at)
- Together, our results support a model in which the LRRs of Kek1 in conjunction with its juxta/transmembrane region direct association and inhibition of the Drosophila EGFR through interactions with receptor domain V. (labome.org)
- Investigation of the genetic topography of the scute locus in Drosophila melanogaster. (nsu.ru)
- Furman D. P., Rodin S. N., Kozhemyakina T. A. Mobile elements distribution and quantitative character penetrance in the scute mutants of Drosophila melanogaster induced in the system of P-M hybrid dysgenesis // Genetika. (nsu.ru)
- Localization of mobile elements P and hobo in the genomes of isofemale Drosophila lines obtained from a natural population from Biisk (Altai) was analyzed using in situ hybridization. (nsu.ru)
- Hairy-wing (Hw) mutations are caused by modifications of the achaete-scute complex (AS-C) which promote development of extra sensory organs on the cuticle of Drosophila melanogaster. (nih.gov)
- Drosophila proneural proteins Achaete (Ac) and Scute (Sc) induce external sensory organ formation by activating neural precursor gene expression. (biologists.org)
- In Drosophila , bHLH proneural proteins encoded by achaete ( ac ) and scute ( sc ) induce the formation of external sensory (ES) organs that function in mechano- and chemo-sensory reception. (biologists.org)
- The achaete-scute complex is expressed in neurogenic regions of Drosophila embryos. (nih.gov)
- The achaete-scute gene complex (AS-C) of Drosophila melanogaster is involved in the development of the embryonic central nervous system and the cuticular sensory organs of both larva and adult. (nih.gov)
- We therefore aimed at generating tumors in restricted lineage subsets with a fast inducing event in parental (F0) animals, independently of GAL4/UAS so that we might employ this binary system (for which most modules exist in Drosophila , including for near genome-wide gain- and loss-of-function, readily available to the community) to cause non-autonomous perturbations on F1 progeny. (elifesciences.org)
- The genome of Drosophila contains two DSL ligands, Delta (Dl) and Serrate (Ser), which are structurally related in their extracellular domain (ECD). (elifesciences.org)
- We identified 2 SNPs, rs3134615 and rs2291854, which were located in the 3′-UTR of the L-MYC gene MYCL1 and the neuronal development Achaete-Scute Complex homolog ASCL1 . (aacrjournals.org)
- The expression of Wnt11 and some neuroendocrine markers increased after the transfection of Achaete-scute complex homolog 1 (ASCL1) into the A549 ADC cell line. (pulmonarycellnews.com)
- Here we show that expression of achaete-scute complex homolog-like 1 ( Ascl1 ) alone is sufficient to convert dorsal midbrain astrocytes of mice into functional iN cells in vitro and in vivo . (jneurosci.org)
- ascl1 (achaete-scute complex homolog 1) gene expression in Xenopus laevis embryos, NF stage 32, as assayed by in situ hybridization. (xenbase.org)
- For example, NvashA , a homolog of the achaete-scute family of basic helix-loop-helix transcription factors, is necessary and sufficient to specify a subset of embryonic neurons. (biomedcentral.com)
- Our study identifies a genome-wide interaction between the pro-longevity transcription factor FOXO3 and the cell fate determinant ASCL1, and raises the possibility that FOXO3's ability to restrain ASCL1-dependent neurogenesis may help preserve the neural stem cell pool. (omicsdi.org)
- Ascl1 regulated Wnt11 expression via lysine H3K27 acetylation at the enhancer region of the WNT11 gene. (pulmonarycellnews.com)
- A: Schematic representation of the ASCL1 genomic DNA depicting exons, introns, transcript and mRNA with untranslated and coding region. (atlasgeneticsoncology.org)
- The human genome contains approximately 125 bHLH factors. (wikipedia.org)
- Proneural proteins bind DNA as heterodimeric complexes that are formed by bHLH proteins or E proteins. (wikipedia.org)
- The basic region and helix 1 of the bHLH domain form a long alpha-helix that is connected with the loop region to helix 2. (wikipedia.org)
- Achaete scute-like 2 (Ascl2), a basic helix-loop-helix (bHLH) transcription factor, is a downstream target of Wnt signaling that controls the fate of intestinal cryptic stem cells and colon cancer progenitor cells. (jove.com)
- These advances include (i) a quadrupling of the density of the genetic map of the mouse, (ii) the ease of genotyping large numbers of marker loci distributed across the entire mouse genome by the polymerase chain reaction, (iii) a far more powerful conceptual framework for mapping quantitative trait loci (QTLs) that underlie complex genetic traits, and (iv) significantly more reliable and economical ways to estimate numbers of neurons. (nervenet.org)
- Advances in medicine, agriculture, and an understanding of evolution depend on resolving the genetic architecture of quantitative traits, which is challenging since variation for complex traits is caused by multiple interacting quantitative trait loci (QTL) with small and conditional effects. (genetics.org)
- Genetic variation in complex traits is thought to be generated by large numbers of loci that usually have comparatively small effects on phenotypes ( Lande, 1981 ). (jneurosci.org)
- Naturally occurring variation at some of these loci such as the AS-C, scabrous , the Delta-Hairless region, contribute to quantitative variation in bristle number. (sdbonline.org)
- In D. melanogaster , QTL loci have also been dissected with quantitative complementation tests [ 9 , 10 ] and/or by linkage disequilibrium (LD) mapping involving a candidate region or locus. (biomedcentral.com)
- We identified 36 novel genome-wide significant loci in the F 34 and 25 novel loci in the F 39-43 cohort. (g3journal.org)
- We complemented these tests with a comprehensive genome scan for additional quantitative trait loci (QTL) to gain a better understanding of the genetic architecture of the ovary size of honey bee workers, a morphological trait that is significant for understanding social insect caste evolution and general insect biology. (biomedcentral.com)
- Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (nih.gov)
- This complex modifies the chromatin and activates gene expression at specific loci depending on the precise cellular context [ 7 , 18 - 21 ]. (biomedcentral.com)
- Moreover, the fact that this locus interferes with multiple aspects of eyespot morphology and maps to a genomic region containing key wing pattern loci in different other butterfly species suggests it might correspond to a 'hotspot' locus in the diversification of this novel trait. (biomedcentral.com)
- A large portion of the human genome is transcribed into RNAs without coding proteins. (hindawi.com)
- Cells were characterized by morphology, proliferation and transepithelial electrical resistance, whole genome transcription analysis, Western blot and immunocytochemical detection of pro-surfactant proteins. (pulmonarycellnews.com)
- Finally, the alteration of the EAST concentrations had no substantial effect on transgene repression if they were inserted either in heterochromatin or in telomeric regions of chromosome 4, as well as on the repression induced by Polycomb group proteins. (deepdyve.com)
- There are approximately 2600 proteins in the human genome that contain DNA-binding domains, and most of these are presumed to function as transcription factors, though other studies indicate it to be a smaller number. (wikipedia.org)
- This mechanism of gene silencing can be mediated by methyl-CpG binding domain (MBD) proteins, which form repressor complexes that are important in linking DNA methylation and transcriptional repression by altering chromatin structure. (ubc.ca)
- In this study, we demonstrate that COI1 associates physically with AtCUL1, AtRbx1, and either of the Arabidopsis Skp1-like proteins ASK1 or ASK2 to assemble ubiquitin-ligase complexes, which we have designated SCF COI1 . (plantcell.org)
- The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. (biomedcentral.com)
- The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes. (biomedcentral.com)
- This review aims to identify and describe different co-repressor proteins that interact directly with CSL proteins to form nuclear repression complexes within specific cells, tissues and different states of development that modulate in a negative fashion Notch dependent gene transcription. (biomedcentral.com)
- Hence we try to deepen on different proteins which share the capability of assembling complexes with the CSL protein family, as well as: CBF-1 interacting repression (CIR) protein, SPEN-SHARP/MINT protein family, Insensitive and BEND6 proteins, KyoT 2 and KyoT 3 proteins, and RITA protein. (biomedcentral.com)
- microRNAs (miRNA) are small, endogenous, noncoding RNAs that simultaneously regulate levels of multiple proteins, primarily by binding to the 3′ untranslated region (UTR) of targets and inhibiting protein translation ( 9 ). (aacrjournals.org)
- Non-coding DNA represents a high proportion of all metazoan genomes. (biomedcentral.com)
- A large fraction of the information content of metazoan genomes resides in the transcriptional and posttranscriptional cis-regulatory elements that collectively provide the blueprint for using the protein-coding capacity of the DNA, thus guiding the development and physiology of the entire organism. (pnas.org)
- Beyond these specific examples, a number of large-scale computational studies have attempted to detect and measure the level of gene organization within eukaryotic genomes. (biomedcentral.com)
- However, the results of these studies, normally consisting of rather weak correlation signals, are insufficient to provide an understanding of the overall gene organization in eukaryotic genomes. (biomedcentral.com)
- In this study, we have pursued this possibility and have mapped a QTL to a gene-rich region on chromosome (Chr) 11 between Hoxb and Krt1 using recombinant inbred (RI) strains. (jneurosci.org)
- LD mapping in D. melanogaster can be implemented with varying degrees of control over genetic and environmental variance from wild caught individuals, laboratory reared iso-female lines, inbred strains, chromosome extraction lines and strains with introgressed chromosome regions. (biomedcentral.com)
- Although an unknown proportion of non-coding DNA might be regarded as "junk DNA", non-coding regions also include important information related to essential processes such as transcriptional and post-transcriptional regulation, splicing, higher-order chromatin structure and DNA replication. (biomedcentral.com)
- The complex blueprint that controls the utilization of the coding information in DNA is contained in the huge number of cis-regulatory elements, both transcriptional and posttranscriptional, that surround and invade the transcribed part of the genome. (pnas.org)
- 1) Occurs via transcriptional activators interacting directly or indirectly with the general transcription complex to increase the efficiency of initiation. (psu.edu)
- While we and others have demonstrated successful generation of functional endothelial-like cells from human embryonic stem cells (hESCs), little is understood regarding the complex transcriptional and epigenetic changes that occur during differentiation, in particular during early commitment to a mesodermal lineage. (biomedcentral.com)
- This result indicates that transcriptional repression by the Groucho/TLE-Xtcf-3 complex is important for ventral diencephalon patterning. (xenbase.org)
- The amount of chromosomal evolution between two species can be expressed as the number of chromosomal rearrangements separating their genomes. (genetics.org)
- I used quantitative trait locus (QTL) mapping to survey the entire genome for chromosomal segments referred to as QTLs that contribute to the phenotypic differences. (ubc.ca)
- We have begun to establish the framework of a provisional cnidarian "endomesodermal" gene regulatory network in the sea anemone, Nematostella vectensis , by using a genome-wide microarray analysis on embryos in which the canonical Wnt/ß-catenin pathway was ectopically targeted for activation by two distinct pharmaceutical agents (lithium chloride and 1-azakenpaullone) to identify potential targets of endomesoderm specification. (prolekare.cz)
- We characterized early and late wound healing events through genome-wide microarray analysis, quantitative PCR, and in situ hybridization to identify potential wound healing targets. (biomedcentral.com)
- Because no gene with such function was found in the orthologous, highly syntenic genomic regions of two other lepidopterans, we hypothesize that our locus is a yet undescribed, possibly lineage-specific, negative regulator of the conserved Wnt/Wg pathway. (biomedcentral.com)
- Many pseudogenes similar to this locus are present in the human genome. (genetex.com)
- A local circuit consisting of specific glutamatergic output and PAM dopaminergic input neurons with overlapping innervation in the MB-β'2 lobe region was identified, which integrates food odor and suppresses innate avoidance. (sdbonline.org)
- Using a combination of genome-wide binding analysis and gene expression profiling, we show that SoxNeuro directs embryonic neural development from the early specification of neuroblasts through to the terminal differentiation of neurons and glia. (biomedcentral.com)
- Whether this is true for neurons within the reticular regions of hindbrain is unknown. (frontiersin.org)
- Some attention is given to factors that regulate epibranchial placode formation, since gustatory neurons are thought to be primarily derived from this region. (biomedcentral.com)
- the interactions between scute, Notch and Delta . (biologists.org)
- In the different species where the Notch signaling pathway (NSP) has been described, the activator complex seems to be widely conserved in its structure and function, whereas the repression complex is surprisingly diverse. (biomedcentral.com)
- Their binding elicits two consecutive proteolytic cleavages of Notch performed by Kuzbanian (Kuz)/ADAM10 and the γ-secretase complex, which results in the release of the intracellular domain (NICD) into the cytoplasm. (elifesciences.org)
- This information generally lays in specific DNA sequences located both in intergenic regions and introns. (biomedcentral.com)
- Furthermore, this influence was shown to be associated with the presence of retrotransposon MDG4 sequences in the pre-promoter gene region. (deepdyve.com)
- For instance, an increase in the EAST concentration had no effect on the expression of mutant alleles of the achaete-scute complex, some of which contained the MDG4 sequences. (deepdyve.com)
- Cis -regulatory sequences are typically located in noncoding regions of the genome and work by binding trans -regulatory molecules called transcription factors (TFs). (g3journal.org)
- Most idiopathic epilepsies are complex diseases with considerable clinical and genetic heterogeneity and an unclear inheritance pattern because of genetic and environmental factors. (bmj.com)
- Genotypes for 25 of these and 14 additional sites in the flanking regions were determined for the 57 NIL and associated with variation in bristle number in four genetic backgrounds. (genetics.org)
- Like other common cancers, SCLC is a complex trait caused by both genetic and environmental factors. (aacrjournals.org)
- Developmental transitions, environmental shifts, and pathogenic invasions lend a dynamic character to both the genome and its activity pattern.We study a variety of natural mechanisms that are utilized by cells adapting to genetic change. (stanford.edu)
- In this review I discuss new data from genome-wide techniques, as well as previous genetic and developmental information, to describe some examples of Hox regulation of different cell functions. (hindawi.com)
- Studies in genetic model organisms have revealed much about the development and pathology of complex tissues. (elifesciences.org)
- To examine the role of misexpressions determined by two maternal copies of the Igf2 / H19 imprinting control region (ICR)-a chromatin insulator, we introduced a mutant ICR (ICR Δ ) into MatDup.dist7 fetuses. (plos.org)
- Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation. (embl-heidelberg.de)
- Expression of a gene then requires opening of a chromatin domain, followed by the steps discussed in Part Three of this course: assembly of a transcription complex. (libretexts.org)
- Near-isoallelic lines (NIL) for the h gene region exhibited significant variation in bristle number and failed to complement a hairy mutation. (genetics.org)
- In this respect, variation in ganglion cell number is a typical complex trait displaying continuous variation over a wide range. (jneurosci.org)
- Here we identify FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (NPCs). (omicsdi.org)
- Cranial placodes, including the otic placode, arise from a common region, the preplacodal domain that extends around the anterior neural plate border. (biomedcentral.com)
- Neural stem cells and their precursors, collectively referred to as neural progenitor cells (NPCs), are present in discrete regions of the mature brain, namely the subgranular zone (SGZ) of the dentate gyrus, the subventricular zone (SVZ), and rostral migratory stream (RMS). (ubc.ca)
- Furthermore, it is often found embedded in known non-coding regulatory regions. (biomedcentral.com)
- Different approaches have been proposed to infer putative cis -regulatory regions. (biomedcentral.com)
- This method generates testable predictions about the function of the putative regulatory regions. (biomedcentral.com)
- As successive whole-genome sequencing projects--including those of mice and humans-are completed, we have full access to the regulatory genome of yet another species. (pnas.org)
- But it is clear that we are in our infancy in learning how to read the regulatory genome and thus decipher the blueprint. (pnas.org)
- In metazoans, many TFs have arisen through local tandem or whole genome duplications followed by neofunctionalisation, a process leading to the generation of new regulatory networks or the modification of existing ones. (biomedcentral.com)
- Our results highlight the association between genome architecture and the gene regulatory networks involved in the construction of the body plan. (biomedcentral.com)
- Understanding the functional relationship between intracellular factors and extracellular signals is required for reconstructing gene regulatory networks (GRN) involved in complex biological processes. (prolekare.cz)
- Epibranchial placodes appear to arise from a pan-placodal region and a number of regulatory factors control the differentiation of individual placodes. (biomedcentral.com)
- The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more transcription factors per gene. (wikipedia.org)
- In a multicellular organism, cell fate is specified by a complex interplay between signaling pathways during embryo development. (biomedcentral.com)
- There has been extensive discussion of the "Replication Crisis" in many fields, including genome-wide association studies ( GWAS ). (g3journal.org)
- Genome-wide association studies ( GWAS ) in model organisms can use genetically identical cohorts phenotyped under extremely similar conditions, which would be expected to enhance the success of replication. (g3journal.org)
- First we evaluated 2,196 SNPs in a case-control study combining nine genome wide association studies (GWAS). (cancer-genetics.org)
- Both ubiquitin adduct and conjugate were linked to the alpha subunit of spectrin, suggesting that the ubiquitin-conjugating (UBC) domain and its target regions reside on the same subunit. (embl-heidelberg.de)
- These results suggest that the COI1 -mediated JA response is dependent on the SCF COI1 complexes in Arabidopsis and that the AXR1 -dependent modification of the AtCUL1 subunit of SCF COI1 complexes is important for JA signaling. (plantcell.org)
- Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development . (wikipedia.org)
- After this period, the preimplantation embryo starts to transcribe from its own genome and produce products, which are necessary for further development. (ijbiotech.com)
- GC development is a complex, multi-step process involving deregulation of several oncogenic pathways. (jcancer.org)
- In this context the NSP is essential to allow a highly regulated cross talk between cells to coordinate their complex organization in space and time during embryo development. (biomedcentral.com)