Acetylserotonin O-Methyltransferase: An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine (MELATONIN).DNA (Cytosine-5-)-Methyltransferase: An enzyme that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to the 5-position of CYTOSINE residues in DNA.Methyltransferases: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.O(6)-Methylguanine-DNA Methyltransferase: An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.Protein Methyltransferases: Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide chain. S-Adenosyl-L-methionine acts as the methylating agent. EC 2.1.1.Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)Histone-Lysine N-Methyltransferase: An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine. EC 2.1.1.43.tRNA Methyltransferases: Enzymes that catalyze the S-adenosyl-L-methionine-dependent methylation of ribonucleotide bases within a transfer RNA molecule. EC 2.1.1.Protein-Arginine N-Methyltransferases: Enzymes that catalyze the methylation of arginine residues of proteins to yield N-mono- and N,N-dimethylarginine. This enzyme is found in many organs, primarily brain and spleen.S-Adenosylmethionine: Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)DNA-Cytosine Methylases: Methylases that are specific for CYTOSINE residues found on DNA.Protein D-Aspartate-L-Isoaspartate Methyltransferase: A PROTEIN O-METHYLTRANSFERASE that recognizes and catalyzes the methyl esterification of ISOASPARTIC ACID and D-ASPARTIC ACID residues in peptides and proteins. It initiates the repair of proteins damaged by the spontaneous decomposition of normal L-aspartic acid and L-asparagine residues.DNA Modification Methylases: Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms.Site-Specific DNA-Methyltransferase (Adenine-Specific): An enzyme responsible for producing a species-characteristic methylation pattern on adenine residues in a specific short base sequence in the host cell DNA. The enzyme catalyzes the methylation of DNA adenine in the presence of S-adenosyl-L-methionine to form DNA containing 6-methylaminopurine and S-adenosyl-L-homocysteine. EC 2.1.1.72.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Amido Black: A dye used to stain proteins in electrophoretic techniques. It is used interchangeably with its acid form.Neurochemistry: The study of the composition, chemical structures, and chemical reactions of the NERVOUS SYSTEM or its components.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Lysosome-Associated Membrane Glycoproteins: Ubiquitously expressed integral membrane glycoproteins found in the LYSOSOME.Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Pineal Gland: A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.Endocrine Glands: Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Melatonin: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Arylalkylamine N-Acetyltransferase: An acetyltransferase with specificity towards the amine group of aromatic alkylamines (arylalkylamines) such as SEROTONIN. This enzyme is also referred to as serotonin acetylase despite the fact that serotonin acetylation can also occur through the action of broad specificity acetyltransferases such as ARYLAMINE N-ACETYLTRANSFERASE.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Catechol O-Methyltransferase: Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.Protein O-Methyltransferase: An enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine to free carboxyl groups of a protein molecule forming methyl esters. EC 2.1.1.-.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Zebrafish: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.Zebrafish Proteins: Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).Embryo, Nonmammalian: The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.Clone Cells: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)Pasteurellosis, Pneumonic: Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.Ships: Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Suprachiasmatic Nucleus: An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.Receptor, Melatonin, MT2: A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.Receptors, Melatonin: A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.5-Methoxytryptamine: Serotonin derivative proposed as potentiator for hypnotics and sedatives.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog. (1/43)

Serotonin N-acetyltransferase, a member of the GNAT acetyltransferase superfamily, is the penultimate enzyme in the conversion of serotonin to melatonin, the circadian neurohormone. Comparison of the structures of the substrate-free enzyme and the complex with a bisubstrate analog, coenzyme A-S-acetyltryptamine, demonstrates that acetyl coenzyme A (AcCoA) binding is accompanied by a large conformational change that in turn leads to the formation of the serotonin-binding site. The structure of the complex also provides insight into how the enzyme may facilitate acetyl transfer. A water-filled channel leading from the active site to the surface provides a pathway for proton removal following amine deprotonation. Furthermore, structural and mutagenesis results indicate an important role for Tyr-168 in catalysis.  (+info)

Melatonin, its precursors, and synthesizing enzyme activities in the human ovary. (2/43)

The presence of melatonin (N-acetyl-5-methoxytryptamine) and its precursors, serotonin (5-hydroxytryptamine) and N-acetylserotonin, was demonstrated in extracts of human ovary using reverse-phase high-performance liquid chromatography coupled with fluorometric detection. In addition, activities of two melatonin-synthesizing enzymes, arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), were found in human ovary homogenates. The apparent Michaelis constants for the substrates of NAT and HIOMT in the human ovary were similar to those reported for the pineal glands of humans and other mammals. These findings strongly suggest that the human ovary, like the pineal gland, may synthesize melatonin from serotonin by the sequential action of NAT and HIOMT.  (+info)

Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities. (3/43)

This study was conducted to determine the origin of the high variability in the mean nocturnal plasma melatonin concentration (MC) in sheep. Two extreme groups of 25 lambs each [low (L) and high (H)] were obtained by calculating their genetic value on the basis of the MC of their parents. The MC of lambs was significantly higher in the H group than in the L group (L: 189.7 +/- 24.4 vs. H: 344.1 +/- 33.0 pg/ml, P < 0.001). Within each group, 13 lambs were slaughtered during the day (D) and 12 lambs during the night (N). Pineal weight was significantly higher in the H group than in the L group (L: 83.5 +/- 6.7 vs. H: 119.1 +/- 9.2 mg, P < 0.01) but did not differ between D and N. The amount of melatonin released in vitro per milligram of pineal gland, the arylalkylamine N-acetyltransferase (AANAT) activity, the AANAT protein content, and the level of AANAT mRNA differed significantly between D and N but not with genetic group. Hydroxyindole O-methyltransferase activity did not differ significantly between D and N or between genetic groups. Therefore, the genetic difference in MC between the two groups of lambs was attributed to a difference in pineal size, not in enzymatic activity of the pinealocytes.  (+info)

Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. (4/43)

Bone marrow is an important tissue in generation of immunocompetent and peripheral blood cells. The progenitors of hematopoietic cells in bone marrow exhibit continuous proliferation and differentiation and they are highly vulnerable to acute or chronic oxidative stress. In this investigation, highly elevated levels of the antioxidant melatonin were identified in rat bone marrow using immunocytochemistry, radioimmunoassay, high performance liquid chromatography with electrochemical detection and mass spectrometry. Night-time melatonin concentrations (expressed as pg melatonin/mg protein) in the bone marrow of rats were roughly two orders of magnitude higher than those in peripheral blood. Measurement of the activities of the two enzymes (N-acetyltransferase (NAT) and hydroxyindole-O-methoxyltransferase (HIOMT)) which synthesize melatonin from serotonin showed that bone marrow cells have measurable NAT activity, but they have very low levels of HIOMT activity (at the one time they were measured). From these studies we could not definitively determine whether melatonin was produced in bone marrow cells or elsewhere. To investigate the potential pineal origin of bone marrow melatonin, long-term (8-month) pinealectomized rats were used to ascertain if the pineal gland is the primary source of this antioxidant. The bone marrow of pinealectomized rats, however, still exhibited high levels of melatonin. These results indicate that a major portion of the bone marrow's melatonin is of extrapineal origin. Immunocytochemistry clearly showed a positive melatonin reaction intracellularly in bone marrow cells. A melatonin concentrating mechanism in these cells is suggested by these findings and this may involve a specific melatonin binding protein. Since melatonin is an endogenous free radical scavenger and an immune-enhancing agent, the high levels of melatonin in bone marrow cells may provide on-site protection to reduce oxidative damage to these highly vulnerable hematopoietic cells and may enhance the immune capacity of cells such as lymphocytes.  (+info)

Regulation of hydroxyindole-O-methyltransferase gene expression in Japanese quail (Coturnix coturnix japonica). (5/43)

Hydroxyindole-O-methyltrasferase (HIOMT) plays an important role as the final enzyme in the synthesis of melatonin. In this study, the expression of the HIOMT gene in Japanese quail was investigated with respect to tissue distribution and the effects of light and vitamin A deficiency. HIOMT mRNA in the pineal gland and eye had a clear daily rhythm with peak values in daytime. The testis also contained a detectable amount of HIOMT mRNA, which did not display a rhythmic change over a 24-h period. When birds were rendered vitamin A deficient through feeding with a vitamin A-free diet, the daily rhythm of the HIOMT gene almost disappeared in both the pineal gland and eye due to increases in the nighttime values. Our previous observations and these results suggest that vitamin A and a photo-signal are required to maintain the rhythmic expression of the HIOMT gene as well as the arylalkylamine N-acetyltransferase gene.  (+info)

Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. (6/43)

We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel.  (+info)

Serotoninergic and melatoninergic systems are fully expressed in human skin. (7/43)

We investigated the cutaneous expression of genes and enzymes responsible for the multistep conversion of tryptophan to serotonin and further to melatonin. Samples tested were human skin, normal and pathologic (basal cell carcinoma and melanoma), cultured normal epidermal and follicular melanocytes, melanoma cell lines, normal neonatal and adult epidermal and follicular keratinocytes, squamous cell carcinoma cells, and fibroblasts from dermis and follicular papilla. The majority of the samples showed simultaneous expression of the genes for tryptophan hydroxylase, arylalkylamine N-acetyltransferase (AANAT), and hydroxyindole-O-methyltransferase (HIOMT). The products of AANAT activity were identified by RP-HPLC with fluorimetric detection in human skin and in cultured normal and malignant melanocytes and immortalized keratinocytes; HIOMT activity was detected in human skin, keratinocytes, and melanoma cells. N-acetylserotonin (NAS) was detected by RP-HPLC in human skin extracts. NAS identity was confirmed further by LC/MS in keratinocytes. In conclusion, we provide evidence that the human skin expresses intrinsic serotonin and melatonin biosynthetic pathways.  (+info)

Molecular cloning and nucleotide sequence of a cDNA encoding hydroxyindole O-methyltransferase from chicken pineal gland. (8/43)

Hydroxyindole O-methyltransferase (EC 2.1.1.4) is the enzyme that catalyses the synthesis of melatonin in the pineal gland and in the retina. Polyadenylated RNA from chicken pineal glands was used to prepare a cDNA library in lambda gt11. The library was screened with an antiserum directed against chicken hydroxyindole O-methyltransferase, and one cDNA clone was isolated. The fusion protein expressed by phage lysogens was identified on Western blots as a 165 kDA immunoreactive protein (beta-galactosidase, 110 kDa; hydroxyindole O-methyltransferase, 38 kDa). The fusion protein exhibited hydroxyindole O-methyltransferase activity. Its Km values for N-acetyl-5-hydroxytryptamine and S-adenosylmethionine were 5 times those of the natural enzyme. The intrinsic activity of the fusion protein was approx. 0.25% that of the natural enzyme. The cDNA consisted of 1436 nucleotides, including a 1038-nucleotide sequence encoding a full-length 346-amino-acid hydroxyindole O-methyltransferase. Comparison with bovine hydroxyindole O-methyltransferase [Ishida, Obinata & Deguchi (1987) J. Biol. Chem. 262, 2895-2899] revealed 52% identity in nucleotide sequences and 44% identity in peptide sequences. Northern-blot analysis revealed the presence of hydroxyindole O-methyltransferase mRNA transcripts in chicken pineal gland and retina, but not in the telencephalon.  (+info)

Radical scavenging properties of tryptophan metabolites were estimated using their radical reactivity. Metabolites of the kynurenine and the melatonin biosynthesis pathway were mainly examined by use...
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Im searching for places that carry one or two special enzymes of the melatonin biosynthetic pathway, (NAT) N-acetyltransferase or (HIOMT) hydroxylindole-O-methyltransferase. Please anyone with any information on where I can buy, borrow from someone in-house stock please contact me. Dr. Klosen any ideas on where I can get the above enzyme(s). Any help or info is greatly appreciated. regards Maria Mejia Smith-Kettlewell Eye Res. Inst. S.F.CA ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
In vertebrates, the essential amino acid L-tryptophan is the precursor of 5-methoxyindoles, or indolamines/tryptamines, including melatonin (N-acetyl-5-methoxytryptamine), through the intermediate serotonin (5-HT, 5-hydroxytryptamine) and the activity of hydroxyindole-O-methyltransferase (HIOMT) [14]. In mammals, melatonin is synthesized in the pineal gland, predominantly during the night-time, although it can be also produced in other organs, such as retina, gastrointestinal tract, lymphocytes and bone marrow cells. Conversely, light at night has an inhibitory effect on pineal melatonin biosynthesis which is initiated by the uptake of tryptophan from the circulation into pinealocytes [15]. Once synthesized, melatonin is not stored in the pineal cells, but it is released into the bloodstream with a circadian rhythm, from which it reaches other body fluids, including urine, saliva, cerebrospinal fluid, bile, semen and amniotic fluid [16, 17]. The circadian rhythm of melatonin secretion is ...
Bioactive peptides from bovine pineal gland and bone marrow extracts. In: Chemistry of Peptides and Proteins DWI Report: Aachen. - 1993. Twenty years of study on effect of pineal peptide preparation: epithalamin in experimental gerontology and oncology // Ann. N.Y. Acad. Sci. - 1994. Click here ...
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Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, NEUROSCIENCES, chicken, pineal gland, retina, circadian rhythm, light, melatonin, serotonin N-acetyltransferase, MELATONIN SYNTHESIS, PERCEIVED LIGHT, JAPANESE-QUAIL, CLOCK, SYSTEM, SUPPRESSION, RECEPTORS, CELLS ...
Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. Decreased calcium ion availability is the si
Abstract Melatonin is the time-keeping molecule of vertebrates. The daily and annual variations of its rhythmic production allow synchronizing metabolism, physiological functions and behaviour to the environment changes. In fish, melatonin is produced by the photoreceptors of the pineal organ and retina as well as by other retinal cell types in the inner nuclear and ganglion cell layers. In most species, the melatonin rhythm displays a high-at-night profile, resulting from the circadian control of the arylalkylamine N-acetyltranferase (AANAT) activity. AANAT is the penultimate enzyme in the melatonin biosynthesis pathway. This review summarizes our current knowledge on the molecular and cellular mecha- nisms controlling the rhythmic production of melatonin, as well as on the targets and modes of action of the hormone in fish, with special emphasis on neuroendocrine functions.. ...
The primary function of the pineal gland is to secrete melatonin, which plays a role in regulating sleep cycles and in sexual development. The pineal gland also helps to regulate endocrine functions...
How you think and feel every day depends on the pineal gland Dr. Edward Group | Global Healing Center The famous philosopher Descartes described the pineal gland as the
The pineal gland is an important gland for connecting us to other dimensions, such as the dream and spiritual plane, because it produces melatonin and DMT.
White, W.F.; Hedlund, M.T.; Weber, G.F.; Rippel, R.H.; Johnson, E.S.; Wilber, J.F., 1974: The pineal gland: a supplemental source of hypothalamic-releasing hormones
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TY - JOUR. T1 - Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia. AU - Amaral, Fernanda G.. AU - Turati, Ariane O.. AU - Barone, Mark. AU - Scialfa, Julieta H.. AU - Do Carmo Buonfiglio, Daniella. AU - Peres, Rafael. AU - Peliciari-Garcia, Rodrigo A.. AU - Afeche, Solange C.. AU - Lima, Larissa. AU - Scavone, Cristoforo. AU - Bordin, Silvana. AU - Reiter, Russel J.. AU - Menna-Barreto, Luiz. AU - Cipolla-Neto, José. PY - 2014/8. Y1 - 2014/8. N2 - Melatonin is a neurohormone that works as a nighttime signal for circadian integrity and health maintenance. It is crucial for energy metabolism regulation, and the diabetes effects on its synthesis are unresolved. Using diverse techniques that included pineal microdialysis and ultrahigh-performance liquid chromatography, the present data show a clear acute and sustained melatonin synthesis reduction in diabetic rats as a result of pineal metabolism impairment that is unrelated to cell death. Hyperglycemia ...
The brain is a powerhouse for activity. There are so many things happening at once in your brain and some of them we dont even realize are going on. The brain governs all of the responses for our bodies and produces these responses as well. There are many different parts of the brain, and one part at the front of the brain is called the pineal gland. The pineal gland is called as such because from an anatomical view, it resembles a pine cone. The pineal glad regulates things like your sleep patterns as well as sexual hormones. The pineal gland is also known as the seat of the soul and is said to connect us with our extrasensory perception. In historic and biblical texts the pineal gland is referred to and is said to be the third eye which can open us up to enlightenment through connecting with our soul and to the rest of the universe. Seeing through the third eye, or pineal gland is not like seeing with your two other eyes, it gives you the ability to see within, to imagine, to have inner ...
The pineal gland is a bit of cone shaped gland which is hidden away deep in the human brain. Although its a small gland, it plays a really crucial role in The aging and melatonin production process
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From the Melanated Man: Just the facts on this post, no preaching today folks! (lol) Mentioned in the Melanin Production post, the pineal gland is where the production of melanin takes place, inside and outside your body. Also mentioned is the fact that the pineal gland needs SUNLIGHT, which is mainly received through the retina…
Cleaning up the Pineal Gland is useful for those wishing to develop their multidimensional perceptio... Cleaning up the Pineal Gland is useful for those wishing
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Located in the brain, the pineal gland is responsible for secreting melatonin, which is a hormone that helps coordinate your circadian rhythm, or internal...
The pineal gland, a pine-cone shaped gland of the endocrine system, is a highly essential part of the brain necessary to our survival. It is often associated with the third eye or the Ajna chakra, when activated, leads one to higher realms of consciousness. The third eye gives us perception of the universe around us…
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A hepatitis A outbreak linked to frozen berries has sickened as many as 56 people in 4 of Europes Nordic countries, according to health officials.. The European Centre for Disease Control and Prevention announced Tuesday that 16 hepatitis A infections arising from the same strain of the virus have been reported in Denmark, Finland, Norway and Sweden. A further 40 cases are suspected to be part of the outbreak, but have not been confirmed by testing.. The first illnesses began in October of last year, and the most recent reported illnesses occurred this month, according to the ECDC report.. Since none of the victims traveled outside the European Union during the time they would have been exposed to the virus, the source of the outbreak is thought to be within the EU, say authorities.. Local investigations within the affected countries "strongly point towards frozen berries as the vehicle of infection," said ECDC in a press release Tuesday.. So far, no samples of frozen berries collected from the ...
Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The gene is translated into a 23 kDa large enzyme. It is well conserved through evolution and the human form of the protein is 80% identical to sheep and rat AANAT. It is an acetyl-CoA-dependent enzyme of the GCN5-related family of N-acetyltransferases (GNATs). It may contribute to multifactorial genetic diseases such as altered behavior in sleep/wake cycle and research is on-going with the aim of developing drugs that regulate AANAT function. The systematic name of this enzyme class is acetyl-CoA:2-arylethylamine N-acetyltransferase. Other names in common use include: AANAT Arylalkylamine N-acetyltransferase Melatonin rhythm enzyme Serotonin ...
Haque, R., Chong, Nelson W., Ali, F., Chaurasia, S.S., Sengupta, T., Chun, E., Howell, J.C., Klein, D.C. and Iuvone, P.M. 2011. Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter. Journal of Neurochemistry. 119 (1), pp. 6-17. doi:10.1111/j.1471-4159.2011.07397.x Cardiac-specific RNAi knockdown of Abra disrupts heart function and alters lifespan in Drosophila melanogaster ...
Editor, In5D.com. More and more people are wearing sunglasses, even if the sun is not shining bright and I see also that little children (toddlers) have sunglasses on. I remember an article by Dr. Ornstein in the Lets live Magazine in October 1980 were it is explained that Sunlight is very important, day light is very vital. The Creator provided for our emotional and physical health by giving us the Pineal Gland and commanding "Let there be Light ". The Pineal Gland is an active, secreting gland throughout life. Natural, unfiltered sunlight is necessary for the proper functioning of this gland. Light as conscious electromagnetic energy from the sun enters the body through the optic nerves of the eyes which, in turn, directly stimulates the pineal gland, a photo reactive organ. The pineal gland converts light energy into an electrochemical impulse which feeds directly into the hypothalamus.. ...
NAS může hrát roli v antidepresivních účincích selektivních inhibitorů zpětného vychytávání serotoninu (SSRI) a inhibitorů monoaminooxidázy (MAOI). [3] SSRI fluoxetin a MAO-A inhibitor klorgylin zvyšuje AANAT nepřímo prostřednictvím serotonergních mechanismů, a tím zvedá hladinu NAS po chronickém podávání, a to koreluje s nástupem jeho antidepresivních účinků. [3] [15] Kromě toho expozice světla inhibuje syntézu NAS a snižuje antidepresivní účinky MAOI. [3] Navíc AANAT u knockout myšíi vykazuje signifikantně větší dobu její nehybnosti oproti kontrolním myším u modelů deprese na zvířatech. [3] Tato data podporují potenciální úlohu NAS v regulaci nálady a terapeutických přínosů vyvolaných antidepresivem. Přes současně neidentifikovaný mechanismus může být NAS příčinou ortostatické hypotenze pozorované při klinické léčbě IMAO. [15] [16] Snižuje krevní tlak u hlodavců a pinealektomie ( epifýza je hlavním místem ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Mitochondrial fatty-acid beta-oxidation (mFAO) plays a central role in mammalian energy metabolism. Multiple severe diseases are associated with defects in this pathway. Its kinetic structure is characterized by a complex wiring of which the functional implications have hardly been explored. Repetitive cycles of reversible reactions, each cycle shortening the fatty acid by two carbon atoms, evoke competition between intermediates of different chain lengths for a common set of promiscuous enzymes (enzymes with activity towards multiple substrates). In our validated kinetic model of the pathway, substrate overload causes a steep and detrimental flux decline. Here, we unravel the underlying mechanism and the role of enzyme promiscuity in it. Comparison of alternative model versions elucidated the role of promiscuity of individual enzymes. Promiscuity of the last enzyme of the pathway, medium-chain ketoacyl-CoA thiolase (MCKAT), was both necessary and sufficient to elicit the flux decline. ...
Dr. R. Glenn Smith, a neurologist at Houston Methodist Medical center in Texas, called the new study 'surprising and possibly exciting, but there&
Pineal Gland Lyrics: It was all a dream, I swear it never happened / I wrote like Edgar Allan, I was po like Edgar Allan / Let me hit the weed, you know I really need that / Missin screws, bendin
MANIFESTATIONS OF EVERYDAY CHAOS DID YOU KNOW THAT YOU HAVE A LOPSIDED PINEAL GLAND? Well, probably you do have one, and it s unfortunate because lopsided Pineal Glands have perverted the Free Spirit of Man, and subverted Life into a frustrating, unhappy and hopeless mess. Fortunately, you have before you a handbook that will show you how to discover your salvation through ERIS, THE GODDESS OF CONFUSION. It will advise you how to balance your Pineal Gland and reach spiritual Illumination. And it will teach you how to turn your miserable mess into a beautiful, joyful, and splendid one ...
The pineal gland hangs on the brain behind its very center. French 18th century scientist Rene Descartes thought that the pineal gland was the core of the
Our Hylands 4 Kids Cold n Mucus Day & Night Value Pack has your child covered, 24 hours a day. The daytime formula works to loosen up their mucus, and ease the congestion, so they can get back to being a kid again.
Our Hylands 4 Kids Cold n Mucus Day & Night Value Pack has your child covered, 24 hours a day. The daytime formula works to loosen up their mucus, and ease the congestion, so they can get back to being a kid again.
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What your body is doing during a day? Heres a full list with all hours and your actions of your organism: 04:00: Your body reaches its minimum potential. The most of time, arrests are made at this hour. 05:00: Melatonins level on the blood begins to drop. Your body starts to realease many hormons. 06:00: Pulse and…. Read More Read More ...
The Arecont AV2100DN Megapixel IP Camera offers 2.0 megapixel video resolution at 1600x1200 pixels. With Arecont IP megapixel NVR software, you get realtime IP megapixel streaming.
MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinone3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 13.1) ...
Retina and anterior neural fold homeobox (Rax) gene encodes a transcription factor essential for vertebrate eye development. Recent microarray studies indicate that Rax is expressed in the adult rat pineal gland and retina. The present study reveals that Rax expression levels in the rat change significantly during retinal development with a peak occurring at embryonic day (E) 18, whereas Rax expression in the pineal is relatively delayed and not detectable until E20. In both tissues, Rax is expressed throughout postnatal development into adulthood. In the mature rat pineal gland, the abundance of Rax transcripts increases 2-fold during the light period with a peak occurring at dusk. These findings are consistent with the evidence that Rax is of functional importance in eye development and suggest a role of Rax in the developing pineal gland. In addition, it would appear possible that Rax contributes to phenotype maintenance in the mature retina and pineal gland and may facilitate 24-h changes in ...
Haque, R., Chong, Nelson W., Ali, F., Chaurasia, S.S., Sengupta, T., Chun, E., Howell, J.C., Klein, D.C. and Iuvone, P.M. 2011. Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter. Journal of Neurochemistry. 119 (1), pp. 6-17. https://doi.org/10.1111/j.1471-4159.2011.07397.x Cardiac-specific RNAi knockdown of Abra disrupts heart function and alters lifespan in Drosophila melanogaster ...
Indole is an extracellular biofilm signal for Escherichia coli, and many bacterial oxygenases readily convert indole to various oxidized compounds including 7-hydroxyindole (7HI). Here we investigate the impact of indole and 7HI on Pseudomonas aeruginosa PAO1 virulence and quorum sensing (QS)-regula …
N-acetylserotonin is converted into melatonin by the enzyme hydroxyindole O-methyltransferase (HIOMT), also known as ... acetylserotonin O-methyltransferase (ASMT). Activity of these enzymes is high during the night and regulated by the mechanisms ... The serotonin is then acetylated by the AANAT enzyme and converted into N-acetylserotonin. ...
Hydroxyindole O-methyltransferase and S-adenosyl methionine convert N-acetylserotonin into melatonin through methylation of the ... N-acetylserotonin is methylated at the hydroxyl position by S-adenosyl methionine (SAM) to produce S-adenosyl homocysteine (SAH ... The thiol from coenzyme A serves as a good leaving group when attacked by a general base to give N-acetylserotonin. ... Donohue SJ, Roseboom PH, Illnerova H, Weller JL, Klein DC (1993). "Human hydroxyindole-O-methyltransferase: presence of LINE-1 ...
N-acetylserotonin O-methyltransferase (ASMT) to generate melatonin. The N-acetyltransferase reaction has been suggested to be ... After the transfer of the acetyl group has occurred, the products are orderly released with N-acetyl-serotonin first and CoA ... In the biosynthesis of melatonin, N-acetylserotonin is further methylated by another enzyme, ... to produce N-acetylserotonin. Based on this mechanism, it might be expected that a bisubstrate analog inhibitor, derived from ...
... thetin-homocysteine S-methyltransferase EC 2.1.1.4: acetylserotonin O-methyltransferase EC 2.1.1.5: betaine-homocysteine S- ... sterol 24-C-methyltransferase EC 2.1.1.42: luteolin O-methyltransferase EC 2.1.1.43: histone-lysine N-methyltransferase EC 2.1. ... methyltransferase EC 2.1.1.6: catechol O-methyltransferase EC 2.1.1.7: nicotinate N-methyltransferase EC 2.1.1.8: histamine N- ... phenol O-methyltransferase EC 2.1.1.26: iodophenol O-methyltransferase EC 2.1.1.27: tyramine N-methyltransferase EC 2.1.1.28: ...
... acetylserotonin n-methyltransferase MeSH D08.811.913.555.500.175 --- betaine-homocysteine S-methyltransferase MeSH D08.811. ... histone-lysine n-methyltransferase MeSH D08.811.913.555.500.800.650 --- o-6-methylguanine-DNA methyltransferase MeSH D08.811. ... protein o-methyltransferase MeSH D08.811.913.555.500.800.800.700 --- protein d-aspartate-l-isoaspartate methyltransferase MeSH ... site-specific dna-methyltransferase (adenine-specific) MeSH D08.811.913.555.500.350.850 --- site-specific dna methyltransferase ...
As of the year 2000, a number of genes were known to be Y-linked, including: ASMTY (acetylserotonin methyltransferase), TSPY ( ...
... and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). NAS is able to penetrate the blood-brain barrier, ... N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical precursor and intermediate in the ... 1999). "N-acetylserotonin is a better extra- and intracellular antioxidant than melatonin". FEBS Lett. 449 (2-3): 206-10. doi: ... February 2010). "N-acetylserotonin activates TrkB receptor in a circadian rhythm". Proceedings of the National Academy of ...
Examples are : Acetylserotonin O-methyltransferase Apigenin 4'-O-methyltransferase Caffeate O-methyltransferase Caffeoyl-CoA O- ... O-methyltransferase Kaempferol 4'-O-methyltransferase Licodione 2'-O-methyltransferase Loganate O-methyltransferase Luteolin O- ... O-methyltransferase Phenol O-methyltransferase Polysaccharide O-methyltransferase Protein-glutamate O-methyltransferase Protein ... methyltransferase Catechol O-methyltransferase Chlorophenol O-methyltransferase Columbamine O-methyltransferase ...
... (ASMT), Acetylserotonin N-methyltransferase, Acetylserotonin methyltransferase (Y ... Acetylserotonin O-methyltransferase The second reaction (Figure 4) catalyzed by N-Acetylserotonin O-methyltransferase in the ... Synonyms of N- Acetylserotonin O-methyltransferase are Hydroxyindole O-methyltransferase (HIOMT), ... suggests that Hydroxyindole O-methyltransferase (synonym for N- Acetylserotonin O-methyltransferase) plays a role in the human ...
... is an enzyme that in humans is encoded by the ASMTL gene. GRCh38: Ensembl ... "Entrez Gene: ASMTL acetylserotonin O-methyltransferase-like". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ...
... is known to act as a histamine N-methyltransferase inhibitor. This explains how harmaline elicits its wakefulness- ... Harmaline forces the anabolic metabolism of serotonin into normelatonin or n-acetylserotonin, and then to melatonin, the body's ... Cumming, P; Vincent SR (September 1992). "Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4- ...
Acetylserotonin O-methyltransferase. arginine→NO. *Nitric oxide synthase (NOS1, NOS2, NOS3). choline→Acetylcholine. ...
... which can be further modified by the enzyme phenylethanol N-methyltransferase to obtain epinephrine.[11] Since L-DOPA is the ...
5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase. *Catechol-O-methyl transferase. Homocysteine. *Betaine ... Information about DNA methyltransferases and DNA methylation at epigeneticstation.com. *Data for a DNA methyltransferase (DNMT ... DNMT1 is the most abundant DNA methyltransferase in mammalian cells, and considered to be the key maintenance methyltransferase ... methyltransferases. Classification of all DNA methyltransferases". Gene. 157 (1-2): 3-11. doi:10.1016/0378-1119(94)00783-O. ...
5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase. *Catechol-O-methyl transferase. Homocysteine. *Betaine ... Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. ... methyltransferase activity. • thiopurine S-methyltransferase activity. • S-adenosyl-L-methionine binding. Cellular component. • ... evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase". J. Pharmacol. Exp. Ther. 266 ( ...
ASMT(英语:Acetylserotonin O-methyltransferase)抑製劑. 异化作用 ...
Hydroxyindole O-methyltransferase and S-adenosyl methionine convert N-acetylserotonin into melatonin through methylation of the ... The thiol from coenzyme A serves as a good leaving group when attacked by a general base to give N-acetylserotonin.[61] ... N-acetylserotonin is methylated at the hydroxyl position by S-adenosyl methionine (SAM) to produce S-adenosyl homocysteine (SAH ... Serotonin is itself an important neurotransmitter, but is also converted into N-acetylserotonin by serotonin N- ...
5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase. *Catechol-O-methyl transferase. Homocysteine. *Betaine ...
... for example by catechol-O-methyl transferase, and is therefore no longer able to act as an electron acceptor. Many polyphenols ...
Hydroxyindole O-methyltransferase and S-adenosyl methionine convert N-acetylserotonin into melatonin through methylation of the ... The thiol from coenzyme A serves as a good leaving group when attacked by a general base to give N-acetylserotonin.[58] ... N-acetylserotonin is methylated at the hydroxyl position by S-adenosyl methionine (SAM) to produce S-adenosyl homocysteine (SAH ... Serotonin is itself an important neurotransmitter, but is also converted into N-acetylserotonin by serotonin N- ...
N-acetylserotonin is converted into melatonin by the enzyme hydroxyindole O-methyltransferase (HIOMT), also known as ... acetylserotonin O-methyltransferase (ASMT). Activity of these enzymes is high during the night and regulated by the mechanisms ... The serotonin is then acetylated by the AANAT enzyme and converted into N-acetylserotonin. ...
Acetylserotonin O-methyltransferase (ASMT), Acetylserotonin N-methyltransferase, Acetylserotonin methyltransferase (Y ... Acetylserotonin O-methyltransferase The second reaction (Figure 4) catalyzed by N-Acetylserotonin O-methyltransferase in the ... Synonyms of N- Acetylserotonin O-methyltransferase are Hydroxyindole O-methyltransferase (HIOMT), ... suggests that Hydroxyindole O-methyltransferase (synonym for N- Acetylserotonin O-methyltransferase) plays a role in the human ...
N-acetylserotonin O-methyltransferase-like protein is an enzyme that in humans is encoded by the ASMTL gene. GRCh38: Ensembl ... "Entrez Gene: ASMTL acetylserotonin O-methyltransferase-like". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ...
Compare acetylserotonin O-methyltransferase like ELISA Kits from leading suppliers on Biocompare. View specifications, prices, ... acetylserotonin O-methyltransferase like ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established ... Your search returned 23 acetylserotonin O-methyltransferase like ELISA ELISA Kit across 2 suppliers. ...
GoPubMed lists recent and important papers and reviews for acetylserotonin O-methyltransferase(hydroxyindole-O- ... The N-acetylserotonin O-methyltransferase (ASMT) gene encodes the enzyme that catalyzes the conversion of N-acetylserotonin to ... Cloning and functional characterization of the Arabidopsis N-acetylserotonin O-methyltransferase responsible for melatonin ... and N-acetylserotonin-O-methyltransferase (ASMT) was analyzed by RT-PCR, q-PCR and Western-blot in ram testes, epididymis, and ...
Recombinant Protein and Acetylserotonin O-methyltransferase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Acetylserotonin O-methyltransferase 1. Acetylserotonin O-methyltransferase 1 ELISA Kit. Acetylserotonin O-methyltransferase 1 ... Acetylserotonin O-methyltransferase 2. Acetylserotonin O-methyltransferase 2 ELISA Kit. Acetylserotonin O-methyltransferase 2 ... Acetylserotonin O-methyltransferase 3. Acetylserotonin O-methyltransferase 3 ELISA Kit. Acetylserotonin O-methyltransferase 3 ...
... while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 ... The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity. The ...
Variants of acetylserotonin o-methyltransferase and uses thereof Luo, Hao Patent no.: WO2017202897, Date: 2017-11-30 ... Method of improving methyltransferase activity Luo, Hao ; Hansen, Anne Sofie Lærke Patent no.: WO2018037098, Date: 2018-03-01 ...
The enzymes AANAT and acetylserotonin O-methyltransferase (ASMT) catalyze the conversion of serotonin to melatonin. Nocturnal ... J. Shen, K. Ghai, P. Sompol et al., "N-acetyl serotonin derivatives as potent neuroprotectants for retinas," Proceedings of the ... M. Bernard, V. Dinet, and P. Voisin, "Transcriptional regulation of the chicken hydroxyindole-O-methyltransferase gene by the ... D. C. Klein and R. Y. Moore, "Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the ...
acetylserotonin O-methyltransferase , hydroxyindole O-methyltransferase , hydroxyindole-O-methyltransferase , acetylserotonin N ... methyltransferase , acetylserotonin methyltransferase (Y chromosome) , HIOMT , acetylserotonin methyltransferase , ... Acetylserotonin O-Methyltransferase (ASMT) ELISA Kits. ASMT belongs to the methyltransferase superfamily, and is located in the ... Cow (Bovine) Acetylserotonin O-Methyltransferase (ASMT) interaction partners * The study revealed that ASMT and MTNR1A (show ...
Acetylserotonin O-methyltransferase-like. 1.62. 3.15. 1.62. 210147571. Acidic (leucine-rich) nuclear phosphoprotein 32 family, ...
Subsequently that compound is catalyzed to melatonin by acetylserotonin O-methyltransferase (ASMT). The rise in circulating ... catalyzes the conversion of serotonin to N-acetylserotonin. ...
Thetin-homocysteine S-methyltransferase Pages 12-14 * Acetylserotonin O-methyltransferase Pages 15-20 ...
HUMAN 402500 Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT) ASMTL Xp22.3 O95671 ... N-acetylserotonin O-methyltransferase-like protein (EC 2.1.1.-) (ASMTL)] ATG4A Xq22.1-q22.3 Q8WYN0 ATG4A_HUMAN 300663 Cysteine ... methyltransferase (EC 2.1.1.205) (2-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) [JM23] FUNDC1 Xp11.4 ... Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) ( ...
... isoflavone-7-O-methyltransferase (EC:2.1.1.150), inositol 4-methyltransferase (EC:2.1.1.129) and acetylserotonin O- ... O-methyltransferase COMT-type (IPR016461). Short name: O-MeTrfase_COMT Family relationships *O-methyltransferase COMT-type ( ... Molecular cloning of a plant N-acetylserotonin methyltransferase and its expression characteristics in rice.. J. Pineal Res. 50 ... This entry represents a family of O-methyltransferases (O-MTases) that includes caffeic acid O-methyltransferase (COMT) (EC:2.1 ...
Acetylserotonin O-methyltransferase. Aliases:. Not Available. RefSeq:. Not Available. Ensembl:. ENSCAFG00000024670 Entrez:. 0 ...
Deficiency of acetylserotonin methyltransferase. *Deficiency of acid-aminoacid ligase. *Deficiency of acid-ammonia ligase ...
Acetylserotonin o-methyltransferase-like. Functionally important candidate genes found in All-Summer, VMN-summer, and Peak-SNV ...
Acetylserotonin O-Methyltransferase1. *Adrenocorticotropic Hormone1. *Catecholamines1. *Circadian Rhythm1 ...
Next-day shipping cDNA ORF clones derived from asmtl acetylserotonin O-methyltransferase-like available at GenScript, starting ... Danio rerio acetylserotonin O-methyltransferase-like (asmtl), mRNA.. pcDNA3.1+/C-(K)DYK or customized vector. 7-9. $342.30. $ ... N-acetylserotonin O-methyltransferase-like protein. Comment. Comment: PROVISIONAL REFSEQ: This record has not yet been subject ... asmtl ( NM_213511.1 ) cDNA ORF clone, Danio rerio(zebrafish) -, NP_998676.1 Danio rerio acetylserotonin O-methyltransferase- ...
Julius Axelrod found that the mechanism behind the breakdown of catecholamine was mediated by catechol-O-methyltransferase - ...
A Comparative Genomic and Transcriptomic Survey Provides Novel Insights into N-Acetylserotonin Methyltransferase (ASMT) in Fish ...
... and N-acetylserotonin O-methyltransferase (ASMT)] (Kang et al., 2007a,b, 2011, 2013; Okazaki et al., 2009; Fujiwara et al., ... Recent studies found that N-acetylserotonin can also be synthesized via caffeic acid O-methyltransferase (COMT) in Arabidopsis ... Caffeic acid O-methyltransferase is involved in the synthesis of melatonin by methylating N-acetylserotonin in Arabidopsis. J. ... Molecular cloning of a plant N-acetylserotonin methyltransferase and its expression characteristics in rice. J. Pineal Res. 50 ...
Molecular cloning of a plant N-acetylserotonin methyltransferase and its expression characteristics in rice. J. Pineal Res. 50 ... temperatures and under dark conditions due to increased serotonin N-acetyltransferase and N-acetylserotonin methyltransferase ... and N-aceylserotonin O-methyltransferase (ASMT) (Arnao and Hernández-Ruiz, 2014, 2015; Zuo et al., 2014). Thereafter, melatonin ... N-aceylserotonin methyltransferase; AXR3, Auxin Resistant 3; BL, indole-3-acetic acid; DAT, days after transplanting; GA, ...
OTTHUMP00000022825,acetylserotonin N-methyltransferase-like. *Related Product. *H00008623-B01P. * ASMTL purified MaxPab mouse ...
  • The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity. (nih.gov)
  • Even within the structurally conserved family of Class I methyltransferases, a wide variety of mechanisms have evolved to activate the catalytic nucleophile, dependent on the polarizability of the target atom [ PMID: 12826405 ]. (ebi.ac.uk)