Acetylserotonin O-Methyltransferase
DNA (Cytosine-5-)-Methyltransferase
Methyltransferases
O(6)-Methylguanine-DNA Methyltransferase
Protein Methyltransferases
Methylation
Histone-Lysine N-Methyltransferase
tRNA Methyltransferases
Protein-Arginine N-Methyltransferases
S-Adenosylmethionine
Protein D-Aspartate-L-Isoaspartate Methyltransferase
DNA Modification Methylases
Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms.
Site-Specific DNA-Methyltransferase (Adenine-Specific)
An enzyme responsible for producing a species-characteristic methylation pattern on adenine residues in a specific short base sequence in the host cell DNA. The enzyme catalyzes the methylation of DNA adenine in the presence of S-adenosyl-L-methionine to form DNA containing 6-methylaminopurine and S-adenosyl-L-homocysteine. EC 2.1.1.72.
The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog. (1/43)
Serotonin N-acetyltransferase, a member of the GNAT acetyltransferase superfamily, is the penultimate enzyme in the conversion of serotonin to melatonin, the circadian neurohormone. Comparison of the structures of the substrate-free enzyme and the complex with a bisubstrate analog, coenzyme A-S-acetyltryptamine, demonstrates that acetyl coenzyme A (AcCoA) binding is accompanied by a large conformational change that in turn leads to the formation of the serotonin-binding site. The structure of the complex also provides insight into how the enzyme may facilitate acetyl transfer. A water-filled channel leading from the active site to the surface provides a pathway for proton removal following amine deprotonation. Furthermore, structural and mutagenesis results indicate an important role for Tyr-168 in catalysis. (+info)Melatonin, its precursors, and synthesizing enzyme activities in the human ovary. (2/43)
The presence of melatonin (N-acetyl-5-methoxytryptamine) and its precursors, serotonin (5-hydroxytryptamine) and N-acetylserotonin, was demonstrated in extracts of human ovary using reverse-phase high-performance liquid chromatography coupled with fluorometric detection. In addition, activities of two melatonin-synthesizing enzymes, arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), were found in human ovary homogenates. The apparent Michaelis constants for the substrates of NAT and HIOMT in the human ovary were similar to those reported for the pineal glands of humans and other mammals. These findings strongly suggest that the human ovary, like the pineal gland, may synthesize melatonin from serotonin by the sequential action of NAT and HIOMT. (+info)Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities. (3/43)
This study was conducted to determine the origin of the high variability in the mean nocturnal plasma melatonin concentration (MC) in sheep. Two extreme groups of 25 lambs each [low (L) and high (H)] were obtained by calculating their genetic value on the basis of the MC of their parents. The MC of lambs was significantly higher in the H group than in the L group (L: 189.7 +/- 24.4 vs. H: 344.1 +/- 33.0 pg/ml, P < 0.001). Within each group, 13 lambs were slaughtered during the day (D) and 12 lambs during the night (N). Pineal weight was significantly higher in the H group than in the L group (L: 83.5 +/- 6.7 vs. H: 119.1 +/- 9.2 mg, P < 0.01) but did not differ between D and N. The amount of melatonin released in vitro per milligram of pineal gland, the arylalkylamine N-acetyltransferase (AANAT) activity, the AANAT protein content, and the level of AANAT mRNA differed significantly between D and N but not with genetic group. Hydroxyindole O-methyltransferase activity did not differ significantly between D and N or between genetic groups. Therefore, the genetic difference in MC between the two groups of lambs was attributed to a difference in pineal size, not in enzymatic activity of the pinealocytes. (+info)Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. (4/43)
Bone marrow is an important tissue in generation of immunocompetent and peripheral blood cells. The progenitors of hematopoietic cells in bone marrow exhibit continuous proliferation and differentiation and they are highly vulnerable to acute or chronic oxidative stress. In this investigation, highly elevated levels of the antioxidant melatonin were identified in rat bone marrow using immunocytochemistry, radioimmunoassay, high performance liquid chromatography with electrochemical detection and mass spectrometry. Night-time melatonin concentrations (expressed as pg melatonin/mg protein) in the bone marrow of rats were roughly two orders of magnitude higher than those in peripheral blood. Measurement of the activities of the two enzymes (N-acetyltransferase (NAT) and hydroxyindole-O-methoxyltransferase (HIOMT)) which synthesize melatonin from serotonin showed that bone marrow cells have measurable NAT activity, but they have very low levels of HIOMT activity (at the one time they were measured). From these studies we could not definitively determine whether melatonin was produced in bone marrow cells or elsewhere. To investigate the potential pineal origin of bone marrow melatonin, long-term (8-month) pinealectomized rats were used to ascertain if the pineal gland is the primary source of this antioxidant. The bone marrow of pinealectomized rats, however, still exhibited high levels of melatonin. These results indicate that a major portion of the bone marrow's melatonin is of extrapineal origin. Immunocytochemistry clearly showed a positive melatonin reaction intracellularly in bone marrow cells. A melatonin concentrating mechanism in these cells is suggested by these findings and this may involve a specific melatonin binding protein. Since melatonin is an endogenous free radical scavenger and an immune-enhancing agent, the high levels of melatonin in bone marrow cells may provide on-site protection to reduce oxidative damage to these highly vulnerable hematopoietic cells and may enhance the immune capacity of cells such as lymphocytes. (+info)Regulation of hydroxyindole-O-methyltransferase gene expression in Japanese quail (Coturnix coturnix japonica). (5/43)
Hydroxyindole-O-methyltrasferase (HIOMT) plays an important role as the final enzyme in the synthesis of melatonin. In this study, the expression of the HIOMT gene in Japanese quail was investigated with respect to tissue distribution and the effects of light and vitamin A deficiency. HIOMT mRNA in the pineal gland and eye had a clear daily rhythm with peak values in daytime. The testis also contained a detectable amount of HIOMT mRNA, which did not display a rhythmic change over a 24-h period. When birds were rendered vitamin A deficient through feeding with a vitamin A-free diet, the daily rhythm of the HIOMT gene almost disappeared in both the pineal gland and eye due to increases in the nighttime values. Our previous observations and these results suggest that vitamin A and a photo-signal are required to maintain the rhythmic expression of the HIOMT gene as well as the arylalkylamine N-acetyltransferase gene. (+info)Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. (6/43)
We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel. (+info)Serotoninergic and melatoninergic systems are fully expressed in human skin. (7/43)
We investigated the cutaneous expression of genes and enzymes responsible for the multistep conversion of tryptophan to serotonin and further to melatonin. Samples tested were human skin, normal and pathologic (basal cell carcinoma and melanoma), cultured normal epidermal and follicular melanocytes, melanoma cell lines, normal neonatal and adult epidermal and follicular keratinocytes, squamous cell carcinoma cells, and fibroblasts from dermis and follicular papilla. The majority of the samples showed simultaneous expression of the genes for tryptophan hydroxylase, arylalkylamine N-acetyltransferase (AANAT), and hydroxyindole-O-methyltransferase (HIOMT). The products of AANAT activity were identified by RP-HPLC with fluorimetric detection in human skin and in cultured normal and malignant melanocytes and immortalized keratinocytes; HIOMT activity was detected in human skin, keratinocytes, and melanoma cells. N-acetylserotonin (NAS) was detected by RP-HPLC in human skin extracts. NAS identity was confirmed further by LC/MS in keratinocytes. In conclusion, we provide evidence that the human skin expresses intrinsic serotonin and melatonin biosynthetic pathways. (+info)Molecular cloning and nucleotide sequence of a cDNA encoding hydroxyindole O-methyltransferase from chicken pineal gland. (8/43)
Hydroxyindole O-methyltransferase (EC 2.1.1.4) is the enzyme that catalyses the synthesis of melatonin in the pineal gland and in the retina. Polyadenylated RNA from chicken pineal glands was used to prepare a cDNA library in lambda gt11. The library was screened with an antiserum directed against chicken hydroxyindole O-methyltransferase, and one cDNA clone was isolated. The fusion protein expressed by phage lysogens was identified on Western blots as a 165 kDA immunoreactive protein (beta-galactosidase, 110 kDa; hydroxyindole O-methyltransferase, 38 kDa). The fusion protein exhibited hydroxyindole O-methyltransferase activity. Its Km values for N-acetyl-5-hydroxytryptamine and S-adenosylmethionine were 5 times those of the natural enzyme. The intrinsic activity of the fusion protein was approx. 0.25% that of the natural enzyme. The cDNA consisted of 1436 nucleotides, including a 1038-nucleotide sequence encoding a full-length 346-amino-acid hydroxyindole O-methyltransferase. Comparison with bovine hydroxyindole O-methyltransferase [Ishida, Obinata & Deguchi (1987) J. Biol. Chem. 262, 2895-2899] revealed 52% identity in nucleotide sequences and 44% identity in peptide sequences. Northern-blot analysis revealed the presence of hydroxyindole O-methyltransferase mRNA transcripts in chicken pineal gland and retina, but not in the telencephalon. (+info)
Radical Scavenging Properties of Tryptophan Metabolites | SpringerLink
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NAT and HIOMT enzymes
5-Hydroxyindole
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N-Acetylserotonin - Wikipedie
N-acetylserotonin (CHEBI:17697)
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Acetylserotonin O-methyltransferase
... (ASMT), Acetylserotonin N-methyltransferase, Acetylserotonin methyltransferase (Y ... Acetylserotonin O-methyltransferase has been determined by X-ray diffraction. N-Acetylserotonin O-methyltransferase can be ... Acetylserotonin O-methyltransferase The second reaction (Figure 4) catalyzed by N-Acetylserotonin O-methyltransferase in the ... Synonyms of N- Acetylserotonin O-methyltransferase are Hydroxyindole O-methyltransferase (HIOMT), ...
N-acetylserotonin O-methyltransferase-like protein
... is an enzyme that in humans is encoded by the ASMTL gene. GRCh38: Ensembl ... "Entrez Gene: ASMTL acetylserotonin O-methyltransferase-like". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ... Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein) at the PDBe-KB. v t e (Articles with short ...
Melatonin
Hydroxyindole O-methyltransferase and S-adenosyl methionine convert N-acetylserotonin into melatonin through methylation of the ... N-Acetylserotonin is methylated at the hydroxyl position by S-adenosyl methionine (SAM) to produce S-adenosyl homocysteine (SAH ... The thiol from coenzyme A serves as a good leaving group when attacked by a general base to give N-acetylserotonin. ... Donohue SJ, Roseboom PH, Illnerova H, Weller JL, Klein DC (October 1993). "Human hydroxyindole-O-methyltransferase: presence of ...
Pinealocyte
N-acetylserotonin is converted into melatonin by the enzyme hydroxyindole O-methyltransferase (HIOMT), also known as ... acetylserotonin O-methyltransferase (ASMT). Activity of these enzymes is high during the night and regulated by the mechanisms ... The serotonin is then acetylated by the AANAT enzyme and converted into N-acetylserotonin. ...
Aralkylamine N-acetyltransferase
N-acetylserotonin O-methyltransferase (ASMT) to generate melatonin. The N-acetyltransferase reaction has been suggested to be ... After the transfer of the acetyl group has occurred, the products are orderly released with N-acetyl-serotonin first and CoA ... In the biosynthesis of melatonin, N-acetylserotonin is further methylated by another enzyme, ... to produce N-acetylserotonin. Based on this mechanism, it might be expected that a bisubstrate analog inhibitor, derived from ...
N-Acetylserotonin
... and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). NAS is able to penetrate the blood-brain barrier, ... "N-Acetyl Serotonin". DrugBank. (CS1 Russian-language sources (ru), Articles without KEGG source, ECHA InfoCard ID from Wikidata ... 1999). "N-acetylserotonin is a better extra- and intracellular antioxidant than melatonin". FEBS Lett. 449 (2-3): 206-10. doi: ... February 2010). "N-acetylserotonin activates TrkB receptor in a circadian rhythm". Proceedings of the National Academy of ...
O-methyltransferase
Examples are : Acetylserotonin O-methyltransferase Apigenin 4'-O-methyltransferase Caffeate O-methyltransferase Caffeoyl-CoA O- ... O-methyltransferase Kaempferol 4'-O-methyltransferase Licodione 2'-O-methyltransferase Loganate O-methyltransferase Luteolin O- ... O-methyltransferase Phenol O-methyltransferase Polysaccharide O-methyltransferase Protein-glutamate O-methyltransferase Protein ... methyltransferase Catechol O-methyltransferase Chlorophenol O-methyltransferase Columbamine O-methyltransferase ...
List of EC numbers (EC 2)
... thetin-homocysteine S-methyltransferase EC 2.1.1.4: acetylserotonin O-methyltransferase EC 2.1.1.5: betaine-homocysteine S- ... methyltransferase EC 2.1.1.6: catechol O-methyltransferase EC 2.1.1.7: nicotinate N-methyltransferase EC 2.1.1.8: histamine N- ... phenol O-methyltransferase EC 2.1.1.26: iodophenol O-methyltransferase EC 2.1.1.27: tyramine N-methyltransferase EC 2.1.1.28: ... inositol 1-methyltransferase EC 2.1.1.41: sterol 24-C-methyltransferase EC 2.1.1.42: flavone 3′-O-methyltransferase EC 2.1.1.43 ...
List of MeSH codes (D08)
... methyltransferases MeSH D08.811.913.555.500.100 - acetylserotonin n-methyltransferase MeSH D08.811.913.555.500.175 - betaine- ... histone-lysine n-methyltransferase MeSH D08.811.913.555.500.800.650 - o-6-methylguanine-DNA methyltransferase MeSH D08.811. ... protein o-methyltransferase MeSH D08.811.913.555.500.800.800.700 - protein d-aspartate-l-isoaspartate methyltransferase MeSH ... homocysteine S-methyltransferase MeSH D08.811.913.555.500.250 - catechol O-methyltransferase MeSH D08.811.913.555.500.350 - dna ...
Y linkage
As of 2000, a number of genes were known to be Y-linked, including: ASMTY (acetylserotonin methyltransferase), TSPY (testis- ...
Harmaline
... is known to act as a histamine N-methyltransferase inhibitor. This explains how harmaline elicits its wakefulness- ... Harmaline forces the anabolic metabolism of serotonin into N-acetylserotonin (normelatonin), and then to melatonin, the body's ... Cumming P, Vincent SR (September 1992). "Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4- ...
Biogenic amine
In addition to the main metabolic pathway, TAs can also be converted by nonspecific N-methyltransferase (NMT) [22] and ... Other biogenic monoamines Trimethylamine Trimethylamine N-oxide Indoleamines Melatonin 6-Hydroxymelatonin N-Acetylserotonin ... phenylethanolamine N-methyltransferase (PNMT) [23] to the corresponding secondary amines (e.g. synephrine [14], N- ...
IJMS | Free Full-Text | Protective Effects of Melatonin on the Skin: Future Perspectives
DeCS 2008 - Changed terms
KEGG REACTION: R06815
O-demethylpuromycin O-methyltransferase [EC:2.1.1.38]. K13066 caffeic acid 3-O-methyltransferase / acetylserotonin O- ... xanthohumol 4-O-methyltransferase [EC:2.1.1.339]. K21786 4-hydroxy-2,2-bipyrrole-5-carbaldehyde O-methyltransferase [EC:2.1.1 ... flavonoid 4-O-methyltransferase [EC:2.1.1.231]. K23157 3-O-acetyl-4-O-demethylpapaveroxine 4-O-methyltransferase subunit ... acetylserotonin O-methyltransferase, plant [EC:2.1.1.4]. K23053 ... carminomycin 4-O-methyltransferase [EC:2.1.1.292]. K15970 8-O- ...
Human Metabolome Database: Showing metabocard for N-Acetylserotonin (HMDB0001238)
2. Acetylserotonin O-methyltransferase. General function:. Involved in O-methyltransferase activity. Specific function:. ... N-Acetylserotonin. Description. N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical ... 3D MOL for HMDB0001238 (N-Acetylserotonin). HMDB0001238 RDKit 3D N-Acetylserotonin 30 31 0 0 0 0 0 0 0 0999 V2000 -5.1424 ... 3D-SDF for HMDB0001238 (N-Acetylserotonin). HMDB0001238 RDKit 3D N-Acetylserotonin 30 31 0 0 0 0 0 0 0 0999 V2000 -5.1424 ...
KEGG ENZYME: 2.1.1.4
acetylserotonin O-methyltransferase;. hydroxyindole methyltransferase;. hydroxyindole O-methyltransferase;. N-acetylserotonin O ... S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin [RN:R03130]. ... acetylserotonin O-methyltransferase. K13066 caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase. ...
in-stock ORF cDNA clones list, human(homo sapiens), page 31
Homo sapiens acetylserotonin O-methyltransferase like (ASMTL), transcript variant 1, mRNA.. OHu29661. ASNA1. Homo sapiens arsA ... Homo sapiens acetylserotonin O-methyltransferase (ASMT), transcript variant 1, mRNA.. OHu19659. ASMT. Homo sapiens ... Homo sapiens acetylserotonin O-methyltransferase (ASMT), transcript variant 3, mRNA.. OHu19659. ASMT. Homo sapiens ... Homo sapiens acetylserotonin O-methyltransferase like (ASMTL), transcript variant 2, mRNA.. OHu17937. ASMTL. ...
Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
The final step of melatonin synthesis is the conversion of NAS to melatonin by hydroxyindole-O-methyl transferase [3, 17-19]. ... F. Lezovalch, M. Sparapani, and C. Behl, "N-Acetyl-serotonin (normelatonin) and melatonin in protect neurons against oxidative ... J. Axelrod, R. J. Wurtman, and S. H. Snyder, "Control of hydroxyindole-O-methyltransferase activity in the rat pineal gland by ... and serotonin is subsequently converted into N-acetylserotonin (NAS) by the enzyme arylalkylamine N-acetyltransferase. ...
PDF) Ni(II) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing...
HETEROCYCLE METABOLIC PROCESS
Code System Concept
DeCS
Acetylserotonin O-Methyltransferase Entry term(s). Acetylserotonin Methyltransferase Acetylserotonin O Methyltransferase HIOMT ... Acetylserotonin O-Methyltransferase Entry term(s):. Acetylserotonin Methyltransferase. Acetylserotonin O Methyltransferase. ... Hydroxyindole O-Methyltransferase Methyltransferase, Acetylserotonin O-Methyltransferase, Acetylserotonin O-Methyltransferase, ... Hydroxyindole O Methyltransferase. Hydroxyindole O-Methyltransferase. Methyltransferase, Acetylserotonin. O-Methyltransferase, ...
DeCS 2008 - Changed terms
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List of EC numbers (EC 2)
guanidinoacetate N-methyltransferase. *: thetin-homocysteine S-methyltransferase. *: acetylserotonin O-methyltransferase. *: ... catechol O-methyltransferase. *: nicotinate N-methyltransferase. *: histamine N-methyltransferase. *: thiol S-methyltransferase ... myricetin O-methyltransferase. *: isoflavone 7-O-methyltransferase. *: cobalt-factor II C20-methyltransferase. *: precorrin-6A ... rRNA (adenine-N6-)-methyltransferase. *: amine N-methyltransferase. *: loganate O-methyltransferase. *: rRNA (guanine-N1-)- ...
IMP: Integrative Multi-species Prediction
Bio2Vec
acetylserotonin O-methyltransferase activity GO:0017096 * methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2- ... 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity ... 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity ...
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Magnoliopsida/fisiología
Search: ce enriched:liver;Hepatocyte 1,Hepatocyte 2;High - The Human Protein Atlas
Methyl group from S-adenosylmethionine2
- A methyl group from S-adenosylmethionine is transferred to NAS by hydroxyindole-O-methyltransferase (HIOMT), and finally NAS is converted to 5-methoxy-N-acetyltryptamine, or melatonin. (hmdb.ca)
- An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine ( MELATONIN ). (bvsalud.org)
Nicotinamide N-methyltransfera3
- Nicotinamide N-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Nicotinamide N-Methyltransferase" by people in this website by year, and whether "Nicotinamide N-Methyltransferase" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Nicotinamide N-Methyltransferase" by people in Profiles. (uchicago.edu)
Serotonin5
- N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical precursor and intermediate in the endogenous production of melatonin from serotonin. (hmdb.ca)
- Serotonin-N-acetyltransferase (SNAT), which regulates the rate of melatonin biosynthesis in the pineal gland, catalyzes the acetylation of 5HT to N-acetylserotonin (NAS). (hmdb.ca)
- Acute administration of irreversible and reversible selective MAO-A inhibitors and high doses (or chronic administration of low doses) of relatively selective MAO-B inhibitors (but not of highly selective MAO-B inhibitors) suppressed MAO-A activity and stimulated N-acetylation of pineal serotonin into N-acetylserotonin, the immediate precursor of melatonin. (hmdb.ca)
- 5-HTP is converted to serotonin by the aromatic amino acid decarboxylase, and serotonin is subsequently converted into N-acetylserotonin (NAS) by the enzyme arylalkylamine N-acetyltransferase. (hindawi.com)
- N-acetyl serotonin is then converted to Melatonin by N-Acetylserotonin O-methyltransferase (ASMT). (nootropicsdepot.com)
TRNA1
- tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1. (genome.jp)
Melatonin3
- N-Acetylserotonin is an intermediate in the metabolic pathway of melatonin and indoleamine in the pineal gland of mammalians. (hmdb.ca)
- N-Acetylserotonin is the product of the O-demethylation of melatonin mediated by cytochrome P-450 isoforms: Cytochrome p450, subfamily IIc, polypeptide 19 (CYP2C19, a clinically important enzyme that metabolizes a wide variety of drugs), with a minor contribution from Cytochrome p450, subfamily I, polypeptide (2CYP1A2, involved in O-deethylation of phenacetin). (hmdb.ca)
- N-Acetylserotonin acts as a potent antioxidant, NAS effectiveness as an anti-oxidant has been found to be different depending on the experimental model used, it has been described as being between 5 and 20 times more effect than melatonin at protecting against oxidant damage. (hmdb.ca)
MRNA1
- Homo sapiens acetylserotonin O-methyltransferase (ASMT), transcript variant 1, mRNA. (genscript.com)
Acid1
- orsellinic acid C2-O-methyltransferase [EC:2.1.1. (genome.jp)
Activity1
- Experimental studies show that N-acetylserotonin possess free radical scavenging activity. (hmdb.ca)
Effects1
- N-acetylserotonin increase after MAO-A inhibitors might mediate their antidepressive and antihypertensive effects. (hmdb.ca)
ASMT4
- Here we focus on the localization of melatonin synthesis using immunohistochemical methods to detect the last enzyme in melatonin synthesis, acetylserotonin O-methyltransferase (ASMT), and in situ hybridization techniques to study transcripts encoding ASMT and two other enzymes in melatonin synthesis, tryptophan hydroxylase (TPH)-1 and aralkylamine N-acetyltransferase. (nih.gov)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Acetylserotonin-O-Methyltransferase (ASMT) in tissue homogenates, cell lysates and other biological fluids. (allelisakits.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Acetylserotonin-O-Methyltransferase (ASMT) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
- One specific correlate of ASD is a low level of melatonin, and one of the enzymes critical in the synthesis of melatonin, acetylserotonin-O-methyltransferase (ASMT, OMIM *300015), is implicated as a susceptibility gene for ASD [82]. (the-mouse-trap.com)
Hydroxyindole-O-methyltransferase4
- Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the final step in melatonin synthesis. (nih.gov)
- Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (nih.gov)
- N-Acetylserotonin is then O-methylated by hydroxyindole O-methyltransferase to form melatonin, S-adenosylmethio- nine serving as the methyl donor (/5). (nih.gov)
- Hydroxyindole O-methyltransferase is highly. (nih.gov)
HIOMT1
- To examine whether magnetic fields (MF) affect N-acetyltransferase (NAT) and hydroxy-indole-O-methyltransferase (HIOMT) activity directly or exert their effect through a cellular pathway that indirectly regulates the activity of these enzymes and melatonin release. (nih.gov)
Protein2
- The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. (nih.gov)
- Caffeate O-methyltransferase-like protein 2 OS=Oryza. (ntu.edu.sg)
Enzyme1
- An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine (MELATONIN). (jefferson.edu)
MeSH1
- Acetylserotonin O-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Glycine1
- Glycine max N-acetylserotonin methyltransferase 2 mRNA, complete cds. (go.jp)
Human1
- Description: A sandwich ELISA kit for detection of Acetylserotonin-O-Methyltransferase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (allelisakits.com)
Classes1
- In other classes (rep- tiles, amphibia, and fish), hydroxy- indole O-methyltransferase is also found in 'the eye and brain as well as the pineal region (J6). (nih.gov)
Total2
- This graph shows the total number of publications written about "Acetylserotonin O-Methyltransferase" by people in this website by year, and whether "Acetylserotonin O-Methyltransferase" was a major or minor topic of these publications. (jefferson.edu)
- Here, a total of 16 putative O-methyltransferase ( ClOMT ) genes were identified in watermelon. (x-mol.com)