A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
Genomic Structural Variation
Phosphoric Diester Hydrolases
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
An improved method for the structural profiling of keratan sulfates: analysis of keratan sulfates from brain and ovarian tumors. (1/982)A previously developed method for the structural fingerprinting of keratan sulfates (Brown et al., Glycobiology, 5, 311-317, 1995) has been adapted for use with oligosaccharides fluorescently labeled with 2-aminobenzoic acid following keratanase II digestion. The oligosaccharides are separated by high-pH anion-exchange chromatography on a Dionex AS4A-SC column. This methodology permits quantitative analysis of labeled oligosaccharides which can be detected at the sub-nanogram ( approximately 100 fmol) level. Satisfactory calibration of this method can be achieved using commercial keratan sulfate standards. Keratan sulfates from porcine brain phosphocan and human ovarian tumors have been examined using this methodology, and their structural features are discussed. (+info)
Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats. (2/982)Evidence for temporal variation in the nephrotoxicity of amphotericin B was recently reported in experimental animals. The role of food in these variations was determined by studying the effect of a short fasting period on the temporal variation in the renal toxicity of amphotericin B. Twenty-eight normally fed and 28 fasted female Sprague-Dawley rats were used. Food was available ad libitum to the fed rats, while the fasted animals were fasted 12 h before and 24 h after amphotericin B injection to minimize stress for the animals. Water was available ad libitum to both groups of rats, which were maintained on a 14-h light, 10-h dark regimen (light on at 0600 h). Renal toxicity was determined by comparing the levels of excretion of renal enzyme and the serum creatinine and blood urea nitrogen (BUN) levels at the time of the maximal (0700 h) or the minimal (1900 h) nephrotoxicity after the intraperitoneal administration of a single dose of dextrose (5%; control group) or amphotericin B (50 mg/kg of body weight; treated group) to the rats. The nephrotoxicities obtained after amphotericin B administration at both times of day were compared to the nephrotoxicities observed for time-matched controls. In fed animals, the 24-h urinary excretion of N-acetyl-beta-D-glucosaminidase and beta-galactosidase was significantly higher when amphotericin B was injected at 0700 and 1900 h. The excretion of these two enzymes was reduced significantly (P < 0.05) in fasting rats, and this effect was larger at 0700 h (P < 0.05) than at 1900 h. The serum creatinine level was also significantly higher (P < 0.05) in fed animals treated at 0700 h than in fed animals treated at 1900 h. Fasting reduced significantly (P < 0.05) the increase in the serum creatinine level, and this effect was larger in the animals treated at 0700 h. Similar data were obtained for BUN levels. Amphotericin B accumulation was significantly higher (P < 0.05) in the renal cortexes of fed rats than in those of fasted animals, but there was no difference according to the time of injection. These results demonstrated that fasting reduces the nephrotoxicity of amphotericin B and that food availability is of crucial importance in the temporal variation in the renal toxicity of amphotericin B in rats. (+info)
Endometrial lysosomal enzyme activity in normal cycling endometrium. (3/982)The objective of this study was to evaluate the possible role of four lysosomal enzymes in endometrial function and remodelling during the normal menstrual cycle by fluorimetric measurement (acid phosphatase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase). A prospective study was conducted of 45 endometrial biopsies obtained from women with normal menstrual cycles. Activity of all four enzymes was identified in human endometrium. Activity of acid phosphatase and N-acetyl-beta-D-glucosaminidase was relatively high, whilst that of alpha-L-fucosidase and alpha-D-mannosidase was low. There was no significant change in the activity of any of the four enzymes from the proliferative to the secretory phase of the cycle. This study suggests that the activity of these enzymes remains constant throughout a major portion of the normal cycle. (+info)
Immediate and early renal function after living donor transplantation. (4/982)BACKGROUND: In order to assess the immediate renal function after living donor transplantation, renal function was compared in eight renal allograft recipients and their living related kidney donors during the first 24 h after transplantation. METHODS: Substantial and comparable intraoperative volume loading with Ringer's acetate and mannitol was performed together with the administration of frusemide. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were estimated by the clearances of inulin and p-aminohippurane, respectively. Tubular reabsorptive function and injury were estimated from the clearance of lithium, the fractional excretion of sodium and the urinary excretion of N-acetyl-beta-glucosaminidase. RESULTS: One hour after completion of surgery, GFR (54 +/- 7 ml/min) and ERPF (294 +/- 35 ml/min) were only 30% lower in the grafts than in the remaining donor kidneys, increasing to similar levels within 3 h. Only minor tubular dysfunction and injury were revealed in the grafted kidneys, and these tended to normalize within 24 h. CONCLUSIONS: By the present transplantation procedure comprising short ischaemia time and substantial volume expansion combined with mannitol and frusemide administration, kidneys from living donors regain nearly normal function within a few hours after transplantation. (+info)
Active site characterization of the exo-N-acetyl-beta-D- glucosaminidase from thermotolerant Bacillus sp. NCIM 5120: involvement of tryptophan, histidine and carboxylate residues in catalytic activity. (5/982)The exo-N-acetyl-beta-d-glucosaminidase (EC 18.104.22.168) from thermotolerant Bacillus sp. NCIM 5120 is a homotetramer with a molecular mass of 240000 kDa. Chemical modification studies on the purified exo-N-acetyl-beta-d-glucosaminidase revealed the involvement of a single tryptophan, histidine and carboxylate, per monomer, in the catalytic activity of the enzyme. Spectral analysis and maintenance of total enzyme activities indicated that N-acetylglucosamine (competitive inhibitor) and p-nitrophenyl-N-acetyl-beta-d-glucosaminide (substrate) prevented the modification of a single essential tryptophan, histidine and carboxylate residue. Kinetic parameters of partially inactivated enzyme (by NBS/HNBB) showed the involvement of tryptophan in substrate binding while that of histidine (by photooxidation/DEPC) and carboxylate (by EDAC/WRK) in catalysis. The Bacillus sp. NCIM 5120 exo-N-acetyl-beta-d-glucosaminidase deviates from the reported N-acetyl-beta-d-glucosaminidases and beta-hexosaminidases that utilize anchimeric assistance in their hydrolytic mechanism. (+info)
Sanfilippo type B syndrome (mucopolysaccharidosis III B): allelic heterogeneity corresponds to the wide spectrum of clinical phenotypes. (6/982)Sanfilippo B syndrome (mucopolysaccharidosis IIIB, MPS IIIB) is caused by a deficiency of alpha-N-acetylglucosaminidase, a lysosomal enzyme involved in the degradation of heparan sulphate. Accumulation of the substrate in lysosomes leads to degeneration of the central nervous system with progressive dementia often combined with hyperactivity and aggressive behaviour. Age of onset and rate of progression vary considerably, whilst diagnosis is often delayed due to the absence of the pronounced skeletal changes observed in other mucopolysaccharidoses. Cloning of the gene and cDNA encoding alpha-N-acetylglucosaminidase enabled a study of the molecular basis of this syndrome. We were able to identify 31 mutations, 25 of them novel, and two polymorphisms in the 40 patients mostly of Australasian and Dutch origin included in this study. The observed allellic heterogeneity reflects the wide spectrum of clinical phenotypes reported for MPS IIIB patients. The majority of changes are missense mutations; also four nonsense and nine frameshift mutations caused by insertions or deletions were identified. Only five mutations were found in more than one patient and the observed frequencies are well below those observed for the common mutations in MPS IIIA. R643C and R297X each account for around 20% of MPS IIIB alleles in the Dutch patient group, whilst R297X, P521L, R565W and R626X each have a frequency of about 6% in Australasian patients. R643C seems to be a Dutch MPS IIIB allele and clearly confers the attenuated phenotype. One region of the gene shows a higher concentration of mutations, probably reflecting the instability of this area which contains a direct repeat. Several arginine residues seem to be 'hot-spots' for mutations, being affected by two or three individual base pair exchanges. (+info)
Effect of age on urinary excretion of N-acetyl-beta-D-glucosaminidase. (7/982)To examine the relationship between the concentrations of urinary NAG and age, we measured ratios of urinary N-acetyl-beta-D-glucosaminidase (NAG) to urinary creatinine (NAG index) in 137 healthy subjects, aged from 19 to 88 years. The study is also designed to evaluate the relationship between urinary NAG and blood pressure. The subjects were divided into 7 subgroups, according to their age (< 30, 30-39, 40-49, 50-59, 60-69, 70-79, 80 or more years). There was a positive correlation between NAG index and age (r = 0.36; P < 0.001). The regression equation relating NAG index (y) to age (x) was y = 0.065x + 0.97. The mean NAG indexes for the 7 subgroups divided by age were significantly different (P < 0.01). There was a positive correlation between NAG index and systolic blood pressure (r = 0.18; P < 0.05), but was not between diastolic blood pressure and NAG index. In multiple regression analysis, age and BUN significantly correlated with NAG index (r = 0.32; P < 0.01, r = 3.3; P = 0.07, respectively), although there was no correlation between systolic blood pressure and NAG index. This cross-sectional study showed a clear elevation in NAG index with age. The rate of elevation was 0.65 per decade. Urinary excretion of NAG may be unrelated to blood pressure. (+info)
A quantitative study of pinocytosis and lysosome function in experimentally induced lysosomal storage. (8/982)The highly pinocytic epithelial cells of the visceral yolk sac from 17.5-day rat conceptuses were used as a model in which to induce engorgement of the vacuolar system by direct accumulation of substances that are not hydrolysed by lysosomal enzymes. The ultra-structural appearances of these cells in pregnant animals that 24-48h before had received intraperitoneal injections of Triton WR-1339, polyvinylpyrrolidone, dextran or sucrose revealed gross abnormalities that were confined to the vacuolar system; in comparison with normal tissue the number, and in some cases the size, of vacuoles was increased, leading to close packing within the apical cytoplasm and distortion of the normal rounded shape. By culturing yolk sacs in vitro, rates of ingestion of 125I-labelled polyvinylpyrrolidone and of 125I-labelled bovine serum albumin were determined, together with the rate of digestion of the labelled protein. The rates of exocytosis of 125I-labelled polyvinylpyrrolidone and of lysosomal enzymes were also determined. No significant differences between normal and highly vacuolated tissues were found. Apparently marked vacuolation of these cells by these agents is without significant effect on pinocytosis, exocytosis or intralysosomal proteolysis. (+info)
Corynebacterium glutamicum possesses β-N-acetylglucosaminidase | BMC Microbiology | Full Text
Here, C. glutamicum was shown to possess N-acetylglucosaminidase activity that is encoded by cg3158/nagA 2 . Structurally, the NagA2 protein belongs to the family 3 glycoside hydrolases, and among these, the N-acetyl-β-D-glucosaminidases show a selective specificity for GlcNAc as substrate  with only few exceptions . N-acetyl-β-D-glucosaminidase activity was assayed with 4-nitrophenyl N,N-diacetyl-β-D-chitobioside as substrate, and about 0.27 mM supported half-maximal activity. In comparison, NagZ from E. coli had a higher Km on the same substrate (0.43 mM) , whereas NagZ of B. subtilis showed an about two fold lower Km of 0.11 ± 0.0 mM with 4-methylumbelliferyl-β-GlcNAc as substrate .. The role of the NagA2 activity in C. glutamicum is still unclear. Analysis of the C. glutamicum transcriptome revealed that the nagA2 gene is transcribed as leaderless transcript with a relatively low RNA abundance . It is not known whether nagA2 expression is regulated in C. ...
NAG elisa kit | Canine N-Acetyl-beta-D-Glucosaminidase ELISA Kit-AAS02154.1
Buy NAG elisa kit, Canine N-Acetyl-beta-D-Glucosaminidase ELISA Kit-AAS02154.1 (MBS005370) product datasheet at MyBioSource, ELISA Kits
EndoS2 is a unique and conserved enzyme of serotype M49 group A Strept by Jonathan Sjogren, Weston B. Struwe et al.
Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, encoding EndoS, has, until now, been thought to be conserved throughout the serotypes. However, in the present study, we identify EndoS2, an endoglycosidase in serotype M49 GAS strains. We characterized EndoS2 and the corresponding ndoS2 gene using sequencing, bioinformatics, phylogenetic analysis, recombinant expression and LC-MS analysis of glycosidic activity. This revealed that EndoS2 is present exclusively, and highly conserved, in serotype M49 of GAS and is only 37% identical with EndoS. EndoS2 showed endo-β-N-acetylglucosaminidase activity on all N-linked glycans of IgG and on biantennary and sialylated glycans of AGP (α1-acid glycoprotein). The enzyme was found to act only on native IgG and AGP and to be
Andrea Cosimo DAmico | Fondazione Santa Lucia
Effects of subthalamic nucleus stimulation on urodynamic findings in patients with Parkinsons diseas, Finazzi-Agrò E, Peppe A, DAmico A, Petta F, Mazzone P, Stanzione P, Micali F, Caltagirone C, J Urol. 2003 Apr;169(4):1388-91.. Urinary N-acetyl-beta-D-glucosaminidase concentration in patients with spinal cord injury: relationship with urodynamic parameters, Finazzi Agrò E, Micali S, Maccarrone M, DAmico A, Vespasiani G, Pasqualetti P, Caltagirone C, Urology 2001 Dec;58(6):870-4.. Ultrasonography of the upper urinary tract in patients with spinal cord injury, Virgili G, Finazzi Agrò E, Giannantoni A, DAmico A, Germani S, Petta F, Vespasiani G, Arch Ital Urol Androl. 2000 Dec;72(4):225-7.. Le flogosi prostatiche: ruolo dellecografia nella diagnosi, Virgili G, Arch Ital Urol Androl., 2000, Edizione Speciale: 29-34.. Percutaneous tibial nerve stimulation (PTNS): short-term vs long-term evaluation, DAmico A, Urodinamica, 12: 2002, 101-102. Trattamento dellincontinenza urinaria neurogena ...
The effect of short-term low-dose cyclosporin on renal function and blood pressure in patients with psoriasis - UEA Digital...
The effect of short-term (mean 2.4 months), low-dose (5 mg/kg) cyclosporin A (CyA) on renal function and blood pressure was studied in eight patients with psoriasis. Studies were undertaken before, during and after treatment. Glomerular filtration rate (GFR) post-treatment was significantly higher than pretreatment or during treatment (pre, 119 +/- 7; during, 113 +/- 9; post, 133 +/- 11 ml/min per 1.73 m2; pre vs. during, NS; during vs. post, P , 0.01; pre vs. post, P , 0.05); effective renal plasma flow (ERPF) was unchanged (pre, 515 +/- 38; during, 485 +/- 49; post, 560 +/- 45 ml/min per 1.73 m2). There was no change in the urinary excretion of either albumin or the enzymes N-acetyl-glucosaminidase, lactate dehydrogenase, alanine aminopeptidase and alkaline phosphatase. There was a decrease in exchangeable sodium which persisted post-treatment (pre, 56 +/- 3; during, 49 +/- 3; post, 49 +/- 3 mmol/kg LBM; pre vs. during, P = 0.07; during vs. post, NS; pre vs. post, P = 0.06). Blood pressure ...
Association between nonalbumin proteinuria and renal tubular damage of N-acetyl-β-D-glucosaminidase and its clinical relevance...
TY - JOUR. T1 - Association between nonalbumin proteinuria and renal tubular damage of N-acetyl-β-D-glucosaminidase and its clinical relevance in patients with type 2 diabetes without albuminuria. AU - Han, Eugene. AU - Kim, Mi Kyung. AU - Lee, Yong ho. AU - Kim, Hye Soon. AU - Lee, Byung Wan. N1 - Funding Information: This study was supported by research grants from Hanmi Pharmaceutical Co., Ltd. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.. PY - 2019/3. Y1 - 2019/3. N2 - Aim: Although albuminuria and urinary N-acetyl-β-D-glucosaminidase (uNAG) are known as progression markers of diabetic kidney disease, there is limited information regarding the association between urinary nonalbumin proteinuria (NAP) and uNAG and the clinical relevance thereof in patients without albuminuria. Methods: This cross-sectional study included samples from 244 consecutive patients with type 2 diabetes mellitus (T2D) without ...
Endo-β-N-Acetylglucosaminidase catalysed glycosylation: tolerance of enzymes to structural variation of the glycosyl amino acid...
Endo-β-N-Acetylglucosaminidases (ENGases) are highly useful biocatalysts that can be used to synthetically access a wide variety of defined homogenous N-linked glycoconjugates in a convergent manner. The synthetic efficiency of a selection of family GH85 ENGases was investigated as the structure of
CAZy - GH84
N-acetyl β-glucosaminidase (EC 22.214.171.124); hyaluronidase (EC 126.96.36.199); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 188.8.131.52 ...
Alfa-N-acetilglukozaminidaza - Википедија, слободна енциклопедија
Werries, E., Wollek, E., Gottschalk, A. and Buddecke, E. (1969). „Separation of N-acetyl-α-glucosaminidase and N-acetyl-α-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-α-galactosaminidase. Eur. J. Biochem. 10: 445-449. PMID 5348072 ...
CAZy - GH35
β-galactosidase (EC 184.108.40.206); exo-β-glucosaminidase (EC 220.127.116.11); exo-β-1,4-galactanase (EC 3.2.1.-); β-1,3-galactosidase (EC 3.2.1.- ...
nag anova random (g04bbc) : NAG Library, Mark 25
For analysis of covariance the residuals are obtained from an analysis of variance of both the response variable and the covariates. The residuals from the response variable are then regressed on the residuals from the covariates using, say, nag_regress_confid_interval (g02cbc) or nag_regsn_mult_linear (g02dac). The results from those functions can be used to test for the significance of the covariates. To test the significance of the treatment effects after fitting the covariate, the residual sum of squares from the regression should be compared with the residual sum of squares obtained from the equivalent regression but using the residuals from fitting blocks only ...
g02hm:: Correlation and Regression Analysis (NAG Toolbox)
function nag_correg_robustm_corr_user_example indm = int64(1); x = [3.4, 6.9, 12.2; 6.4, 2.5, 15.1; 4.9, 5.5, 14.2; 7.3, 1.9, 18.2; 8.8, 3.6, 11.7; 8.4, 1.3, 17.9; 5.3, 3.1, 15; 2.7, 8.1, 7.7; 6.1, 3, 21.9; 5.3, 2.2, 13.9]; a = [1; 0; 1; 0; 0; 1]; theta = [0; 0; 0]; user = [4, 2]; [user, covar, aOut, wt, thetaOut, nit, ifail] = ... nag_correg_robustm_corr_user(@ucv, indm, x, a, theta, user, user) function [userp, u, w] = ucv(t, userp) cu = userp(1); u = 1.0; if (t ~= 0) t2 = t*t; if (t2 , cu) u = cu/t2; end end % w function and derivative cw = userp(2); if (t , cw) w = cw/t; else w = 1.0; end ...
Mucopolysaccharidosis type IIIB may predominantly present with an attenuated clinical phenotype.
Mucopolysaccharidosis type IIIB (MPS IIIB, Sanfilippo syndrome type B) is a lysosomal storage disorder caused by deficiency of the enzyme N-acetyl-alpha-D-glucosaminidase (NAGLU). Information on the natural course of MPS IIIB is scarce but much needed in view of emerging therapies. To improve knowledge on the natural course, data on all 52 MPS IIIB patients ever identified by enzymatic studies in the Netherlands were gathered. Clinical data on 44 patients could be retrieved. Only a small number (n = 9; 21%) presented with a classical MPS III phenotype; all other patients showed a much more attenuated course of the disease characterized by a significantly slower regression of intellectual and motor abilities. The majority of patients lived well into adulthood. First signs of the disease, usually mild developmental delay, were observed at a median age of 4 years. Subsequently, patients showed a slowing and eventually a stagnation of development. Patients with the attenuated phenotype had a stable ...
Mucopolysaccharidosis Type Iiib: Disease Bioinformatics: Novus Biologicals
Learn more about Mucopolysaccharidosis Type Iiib from related diseases, pathways, genes and PTMs with the Novus Bioinformatics Tool.
Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 18.104.22.168) - Pipeline Review, H1 2016 | Aug 16, 2016 ...
Press Release issued Aug 16, 2016: The report provides comprehensive information on the Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 22.214.171.124), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 126.96.36.199) targeted therapeutics development and features dormant and discontinued projects.
Extension of Study HGT-SAN-055 Evaluating Administration of rhHNS in Patients With Sanfilippo Syndrome Type A (MPS IIIA) - Full...
Sanfilippo syndrome, or Mucopolysaccharidosis (MPS) III, is a rare lysosomal storage disease (LSD) caused by loss in activity of 1 of 9 enzymes necessary for degradation of the glycosaminoglycan (GAG) heparan sulfate (HS) in lysosomes. MPS IIIA results from deficiency of the enzyme heparan N-sulfatase (sulfamidase). In the absence of this enzyme, intermediates of the HS degradation process accumulate in the lysosomes of neurons and glial cells, with lesser accumulation outside the brain. MPS IIIA symptoms arise on average at 7 months of age, with the average age of diagnosis at 4.5 years for the majority of patients. Patients present a wide spectrum and severity of clinical symptoms. The central nervous system (CNS) is the most severely affected organ system in patients with MPS IIIA, evidenced by deficits in language development, motor skills, and intellectual development. In addition, there are abnormal behaviors including but not limited to aggression and excess motor activity/hyperactivity ...
Microbiology Society Journals | Porphyromonas gulae sp. nov., an anaerobic, gram-negative coccobacillus from the gingival...
A new species, Porphyromonas gulae sp. nov., is proposed to include strains isolated from the gingival sulcus of various animal hosts which are distinct from related strains of Porphyromonas gingivalis of human origin. This bacterium exhibits the following characteristics: black-pigmented colonies; asaccharolytic, obligate anaerobic growth; and Gram-negative, non-motile and non-spore-forming, rod-shaped cells. Colonies do not fluoresce under UV light. Vitamin K1 and haemin are required for growth. Cells haemagglutinate sheep erythrocytes. Major fatty acid end products are butyric acid, isovaleric acid, succinic acid and phenylacetic acid. Strains are catalase-positive and indole is produced. Alkaline phosphatase, trypsin-like and N-acetyl-beta-glucosaminidase activities are strong. A beta-galactosidase and a glutamylglutamic acid arylamidase are also present. The G+C content of the chromosomal DNA is 51 mol%. DNA-DNA homology data and 16S rRNA gene sequence analysis provide strong evidence that strains
Lysogene to Host Key Opinion Leader Meeting on Gene Therapy for Patients with Sanfilippo Syndrome Type A in New York City -...
Regulatory News: Lysogene (Paris:LYS) (FR0013233475 - LYS), a leading, biopharmaceutical company pioneering gene therapy technologies to treat central nervous system diseases, today
Mucopolysaccharidosis Type IIIb (MPS3B)
Bei dieser Erkrankung haben betroffene Hunde Symptome wie unwillkürliches Muskelzittern und Gleichgewichtsstörungen, die sich immer weiter verschlimmern.
Interferon gamma attenuates hypertensive renal injury in salt-sensitive Dahl rats. | Hypertension
Evidence has been provided that the immunological mechanism is involved in the genesis or maintenance of hypertension. In the present study, we investigated the effects of interferon gamma, a potent immunomodulator derived from lymphocytes, on hypertension and organ damage in Dahl salt-sensitive rats and in spontaneously hypertensive rats. Subcutaneous injection of interferon gamma (5 x 10(4) units/kg body wt once a week for 10 weeks) reduced blood pressure in Dahl salt-sensitive rats fed a 4% high salt diet (174 versus 194 mm Hg, p less than 0.025). This blood pressure reduction was associated with an improvement of renal functions, an increase in glomerular filtration rate (690 versus 569 ml/day/100 g body wt, p less than 0.05), and decreases in urinary protein excretion (48 versus 78 mg/day/100 g body wt, p less than 0.025) and urinary N-acetyl-beta-D-glucosaminidase excretion (143 versus 183 milliunits/day/100 g body wt, p less than 0.05). Morphological investigation showed a marked ...
NAGLU Antibody (monoclonal) (M02) - Mouse monoclonal antibody raised against a partial recombinant NAGLU. WB - Buy Now! |Abgent
NAGLU Antibody (monoclonal) (M02), Mouse monoclonal antibody raised against a partial recombinant NAGLU. validated in WB (AT2970a), Abgent
N-acetil-β-D-glicosaminidase como biomarcador precoce de disfunção renal para a exposição ocupacional ao chumbo inorgânico<...
TY - JOUR. T1 - N-acetil-β-D-glicosaminidase como biomarcador precoce de disfunção renal para a exposição ocupacional ao chumbo inorgânico. AU - Gonçales, Leandro Nishikawa. AU - Paoliello, Mônica Maria Bastos. AU - Janeiro, Vanderly. AU - Machinski, Miguel. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2008/8. Y1 - 2008/8. N2 - Objective: This study aimed to verify the enzymatic activity of N-acetyl-β-D-glucosaminidase (NAG) as a possible early biomarker of renal dysfunction due to occupational exposure to inorganic lead. Materials and methods: We selected a group of 30 males that had been exposed to inorganic lead in a battery factory in the state of Paraná. This group comprised those employees whose blood lead levels were below 40 mg/dl. The control group consisted of 15 healthy adults of similar age and gender compared with the exposed group. Blood lead concentrations, d-aminolevulinic acid levels and urinary NAG activity were measured. Results and ...
Pilot Newborn Screening for Sanfilippo Type A, B Launches in New York - BioNewsFeeds
The U.S. largest pilot newborn screening program for multiple disorders, including Sanfilippo syndrome type A and type B, has launched across eight hospitals in New York. The new screening test - called ScreenPlus - will expand the current newborn testing program to include 14 additional disorders not currently on New York states routine infant screening panel. The test is performed using a drop of dried blood. The blood is collected by pricking an infants heel…. ...
wbir.com | Guardians for Garrett is a kickball tournament with a purpose
We dont really play each other because hes younger than me. And he doesnt really play anymore. He just dribbles at home, Dylan said.. Garrett is slowly losing his motor skills, his speech, and his ability to understand. The 8-year-old has a rare genetic disorder.. Mucopolysaccharidoses, or MPSIII or Sanfilippo Syndrome Type IIIA, Scott said. Theres no cure, theres no treatment. And thats what he is dealing with.. His mother Kelli said, He fights the fight and smiles every day.. Garrett has a support network and a fan club at Alcoa Elementary School.. Theyre like the second parents. When we are not with him we trust them totally with Garrett and they love him, Scott said.. They love him and it shows. He is kind of the mayor of the school and beyond.. Everywhere we go and everyone we see most people around this area know who he is. We dont know them but they know him. So its remarkable, Kelli said.. We walk in the park and people come up and say hi Garrett and I dont even I ...
keratanase II Summary Report | CureHunter
keratanase II: an endo-beta-N-acetylglucosaminidase; cleaves the beta(1-3)-glycosidic bond of a fucosylated 6-O-sulfated N-acetylglucosamine
Pre GI: SWBIT SVG BLASTN
General Information: This strain was isolated from the Baltic Sea. A psychrophilic bacterium. This genus includes species that inhabit a wide range of environments and are capable of utilizing a wide variety of electron acceptors during anaerobic respiration including some insoluble metal oxides while using very few carbon sources such as lactate or acetate. This group of organisms have been studied extensively for their electron transport systems.This species is differentiated from other Shewanella spp. based on its ability to grow at 4 degrees C but not at 37, production of N-acetyl-beta-glucosaminidase, lack of chymotrypsin, and ability to use a variety of complex carbon compounds as carbon and energy sources. ...
Research - United States
Dr. Haiyan Fu. Dr. Fu has developed an efficient gene therapy procedure to treat MPSIIIB. We have made an AAV9 vector that has the ability to cross the blood-brain-barrier. This AAV9 vector carries the gene for NAGLU, the enzyme missing in MPSIIIB patients. By a singly intravenous injection of this AAV9-NAGLU vector, we were able to restore the NAGLU enzyme activity and correct the lysosomal storage pathology throughout the brain, spinal cord and multiple somatic tissues in adult MPSIIIB mice. Most importantly, the AAV9-vector-treated mice showed significant behavioral improvement and survived to a normal lifespan. In addition, this approach is minimally invasive and the IV injection itself has minimal risk to patients. With the generous support from the Sanfilippo families and friends through Bens Dream - The Sanfilippo Research Foundation, the experiments of this project are still ongoing.. We believe that we are in a very good position to move our AAV9-gene-therapy approach to clinical ...
A Comparison of the Isoenzymes of N-Acetyl-β-glucosaminidase in Primate Kidney and Serum | Biochemical Society Transactions
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Purification and characterization of exo-β-1,4-glucosaminidase produced by chitosan-degrading fungus, Penicillium sp. IB-37-2A ...
Chitosan-degrading fungal strain, Penicillium sp. IB-37-2A, produced mainly extracellular chitosanolytic enzymes under submerged agitating cultivation in p
NIH grant for the move toward clinical trials targeting the lysosomal storage disea... ( Investigators at Nationwide Children....
Health, ...Investigators at Nationwide Childrens have received a grant from the ...Mucopolysaccharidosis (MPS) IIIB also known as Sanfilippo Syndrome B... To date the greatest challenge in developing therapies for MPS IIIB ...For more than a decade Dr. Fus team in the Center for Gene Therapy i...,NIH,grant,for,the,move,toward,clinical,trials,targeting,the,lysosomal,storage,disease,MPSIIIB,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
β-N-Acetylhexosaminidasef | NEB
β-N-Acetylhexosaminidasef is a recombinant protein fusion of β-N-Acetyl-hexosaminidase and maltose binding protein. It has identical activity to β-N-Acetyl-hexosaminidase. β-N-Acetyl-hexosaminidasef catalyzes the hydrolysis of terminal β-D-N-acetyl-galactosamine and glucosamine residues from oligosaccharides. β-N-Acetyl-hexosaminidasef can be used to remove O-GlcNAc (N-Acetylglucosaminidase on serine/threonine).
Bearing NAG4907UU manufactured by IKO can be ordered
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Vol 16, No 4 (2013)
Takayuki Furuishi , Yukiko Kato , Toshiro Fukami , Toyofumi Suzuki , Tomohiro Endo , Hiromasa Nagase , Haruhisa Ueda , Kazuo Tomono ...
HIPOTERMIA TERAPEUTYCZNA PDF
HIPOTERMIA TERAPEUTYCZNA PDF - HIPOTERMIA TERAPEUTYCZNA PO NAGŁYM ZATRZYMANIU KRĄŻENIA. - ZALETY przeciwwskazania oraz korzyści ze stosowania hipotermii. W ramach Programu stosowane są
HIPOTERMIA TERAPEUTYCZNA PDF
HIPOTERMIA TERAPEUTYCZNA PDF - HIPOTERMIA TERAPEUTYCZNA PO NAGŁYM ZATRZYMANIU KRĄŻENIA. - ZALETY przeciwwskazania oraz korzyści ze stosowania hipotermii. W ramach Programu stosowane są
HIPOTERMIA TERAPEUTYCZNA PDF
HIPOTERMIA TERAPEUTYCZNA PDF - HIPOTERMIA TERAPEUTYCZNA PO NAGŁYM ZATRZYMANIU KRĄŻENIA. - ZALETY przeciwwskazania oraz korzyści ze stosowania hipotermii. W ramach Programu stosowane są
NAGLU gene - Genetics Home Reference
At least 118 mutations in the NAGLU gene have been found to cause mucopolysaccharidosis type IIIB (MPS IIIB). Most of these mutations change single DNA building blocks (nucleotides) in the gene. All of the mutations that cause MPS IIIB reduce or eliminate the function of alpha-N-acetylglucosaminidase.. The lack of alpha-N-acetylglucosaminidase activity disrupts the breakdown of a subset of GAGs called heparan sulfate. As a result, partially broken down heparan sulfate accumulates within lysosomes. Researchers believe that the accumulation of GAGs interferes with the functions of other proteins inside the lysosomes and disrupts the normal functions of cells. It is unknown why the buildup of heparan sulfate mostly affects the central nervous system in MPS IIIB. ...
Mucopolysaccharidosis IIIB and mild skeletal anomalies: coexistence of NAGLU and CYP26B1 missense variations in the same...
Sanfilippo type B syndrome (mucopolysac-charidosis type IIIB; MPS IIIB) is an autosomal recessive lysosomal storage disorder. It is caused by a critically reduced α-2-acetamido-2-deoxy-D-glucoside acetamidodeoxy glucohydrolase (α-N-acetylglucosaminidase or NAGLU) activity. Recently, an autosomal recessive disorder of skeletal dysplasia associated with CYP26B1 was reported in three families, in which the patients were all homozygous variations. However, the co-occurrence of two rare diseases in a person is very rare. Here, we reported one patient with two novel pathogenic missense variations in NAGLU and CYP26B1. We found an infant with biallelic variation both in NAGLU-compound heterozygous c.1843C | T (p. R615C) and c.1224C | A (p. H408Q) as well as in CYP26B1-compound heterozygous c.529G | A (p. E177K) and c.525C | A (p. H175Q). All variations were novel but predicted pathogenicity according to American College of Medical Genetics and Genomics (ACMG) guidelines. The main phenotypes of the infant
University of California, Los Angeles: Dr. Elizabeth Neufeld | Cure Kirby
Update from the laboratory of Dr. Elizabeth Neufield - November 2011. Our studies of the Sanfilippo syndrome (MPS III) continue along two lines - what is wrong in the brain and how can we treat it? We use the MPS IIIB mouse model for these studies. The primary defect in MPS IIIB is a mutation in the gene (Naglu) encoding ?-N-acetylglucosaminidase, one of the lysosomal enzymes needed for the breakdown of heparan sulfate. As a result, there is a deficiency of α-N-acetylglucosaminidase and heparan sulfate accumulates in lysosomes. But in addition, there is a small area of the brain (the medial entorhinal cortex or MEC) where a number of apparently unrelated substances accumulate; one of these also accumulates in another small area, the dentate gyrus. The medial entorhinal cortex and the dentate gyrus, which are connected to each other, are involved in learning and memory. While our primary study system is the mouse model of MPS IIIB, we have found similar pathology in the brain of the mouse model ...
DMOZ - Health: Conditions and Diseases: Nutritional and Metabolic Disorders: Inherited: Sanfilippo Syndrome
Sanfilippo Syndrome (MPS III), an autosomal recessive hereditary disorder, is characterized by severe mental deterioration, mild physical defects and the excretion of heparan sulfate in the urine. There are four types of Sanfilippo Syndrome; types A and B are the most common forms.
Sanfilippo Syndrome - Public munhcenter
In Sanfilippo syndrome, mucopolysaccharides are stored primar ily in the nerve system. There are four different enzyme deficiencies that cause Sanfilippo syndrome and hence the syndrome is classified as type A, B, C or D.. Type A is considered the most severe form, type B consists of both a milder and more severe form, and type C is considered to lie between types A and B in severity. Type D is very uncommon. The children are born healthy and develop normally up to between 2 and 6 years of age, after which developmental disorders, such as delayed speech and language development, and autistic traits appear.. Extreme hyperactivity is common. Thereafter, a progressive deter ioration occurs. Gradually mental retardation becomes apparent. In the next phase, balance worsens, as well as the ability to walk and mental capabilities. Epilepsy may occur. Skeletal deformities and stiffness of the joints may occur. Respiratory tract infections are common. Ear infections may cause hear ing impairments. ...
Sanfilippo Syndrome Possible Treatment
Drugs used in Alzheimers disease may result in a treatment for a rare genetic brain disease in babies called Sanfilippo syndrome. The new research suggests that new Alzheimers drugs may provide treatment for the currently untreatable metabolic disorder. Sanfilippo syndrome causes severe mental retardation and death
Sanfilippo | Strides For Sophie
The MPS Family of Diseases. There is a continuous process in the body of replacing used materials and breaking them down for disposal. Children born with Mucopolysaccharide or MPS are unable to produce one of the enzymes essential for this process. Used materials cannot be broken down and remain stored in the cells of the body.. Babies born with one of the nine forms of MPS may show no sign of the disease, but as more and more cells become damaged by the storage of used material, symptoms begin to appear. Sadly the MPS family of disease is progressive which lead to an increase in symptoms and the problems they create as the years go by.. Sanfilippo Syndrome. Sanfilippo Syndrome is one of nine mucopolysaccharide diseases. Also known as MPS lll, it takes its name from Dr. Sanfilippo who was one of the doctors who first described the condition in 1963. MPS III is subdivided into 4 similar subtypes. Sophie suffers from the particular subtype MPS III B.. How does the disease progress?. Children begin ...
Structural Biochemistry/Protein function/Regulation - Wikibooks, open books for an open world
Sanfilippo Syndrome is within a set of neurodegenerative diseases called tauopathies (the most common of which is Alzheimers Disease). Although there are 4 subtypes of Sanfilippo Syndrome, they are all characterized by reduced degradation of heparan sulfate (see Hurler Syndrome section) due to reduced levels of a lysosomal enzyme. It was found in a mouse model (MPS IIIB) that there were significantly increased levels of the protein lysozyme; increased levels of this disease were found to cause the creation of hyperphosphorylated tau which is found in the brains of Alzheimers patients and patients with other tauopathies. Significant research is being done in Alzheimers disease which may carry over to Sanfilippo Syndrome as well due to their similarities. 1. 4 different subtypes: Each Sanfilippo subtype is caused by the deficiency of each specific enzyme: heparin N-sulfatase for MPS-III A, N-acetyl-alpha-D-glucosaminidase for MPS-III B, acetyl-CoA: alpha-glucosaminide acetyltransferase for ...
Print - Abeona Announces Top-Line One Year Data from ABO-102 MPS IIIA Trial at ARMs Cell & Gene Meeting on the Mesa
Systemic Biopotency demonstrated time- and dose-dependent reductions of disease causing Heparan Sulfate in the Cerebrospinal fluid (CSF) and liver volumes. --Preservation of deep brain architecture observed after intravenous administration --Stabilization of neurocognitive assessment scores at one year post-injection. NEW YORK and CLEVELAND, Oct. 06, 2017 (GLOBE NEWSWIRE) -- Abeona Therapeutics Inc. (NASDAQ:ABEO), a leading clinical-stage biopharmaceutical company focused on developing novel gene and cell therapies for life-threatening rare diseases, announced one year data from Cohort 1 of the ongoing ABO-102 Phase 1/2 trial for Sanfilippo syndrome Type A (MPS IIIA). The results demonstrated robust and durable clinical effects achieved one year post-administration, with significant reductions in biopotency and biophysical measures, preservation of deep brain architecture, and stabilization across multiple neurocognitive assessments reported in comparison to untreated control subjects. The ...
Remembering our Children<...
Kerrin passed away on March 10, 2007 at the age of 13. She is lovingly remembered by her family and friends, and by all who knew her from the Society.. Hi, My name is Kerrin Bankert. My birthday is May 7th, 1993. You may have already read about my brother Matthew in November 2000, Child of the Month. When I was about 5 months old Mom and Dad started to investigate why Matt wasnt developing like they thought he should. They had no idea that anything could possibly be wrong with me as I certainly was a healthy little girl. Mom and Dad took me for tests after Matthew was diagnosed to confirm what I suppose they already knew. I too have Sanfilippo Syndrome Type IIIA.. As a baby I appeared very healthy and normal although I did have a lot of ear and throat infections. I went to the hospital to get my tonsils and adenoids out and tubes put in my ears then I didnt get sick quite so often. Mom kept a calendar with all my milestones like when I first sat up, rolled, crept, walked and talked and ...
Molecular and Biochemical Characterization of a Novel β-N-Acetyl-D-Hexosaminidase with Broad Substrate-Spectrum from the Aisan...
1. Slámová K, Bojarová P, Petrásková L. et al. β-N-Acetylhexosaminidase: Whats in a name…?. Biotechnol Adv. 2010;28:682-93 2. Merzendorfer H, Zimoch L. Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases. J Exp Biol. 2003;206:4393-412 3. Nagamatsu Y, Yanagisawa I, Kimoto M. et al. Purification of a chitooligosaccharidolytic β-N-acetylglucosaminidase from Bombyx mori larvae during metamorphosis and the nucleotide sequence of its cDNA. Biosci Biotechnol Biochem. 1995;59:219-25 4. Yang Q, Liu T, Liu F. et al. A novel β-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis (Guenée). FEBS J. 2008;275:5690-702 5. Liu T, Zhang H, Liu F. et al. Structural determinants of an insect β-N-acetyl-D-hexosaminidase specialized as a chitinolytic enzyme. J Biol Chem. 2011;286:4049-58 6. Zheng YP, Krell PJ, Doucet D. et al. Cloning, expression, and localization of a molt-related β-N-acetylglucosaminidase in the Spruce budworm, Choristoneura ...
John B. Sanfilippo & Son food business news, John B. Sanfilippo & Son company profile, John B. Sanfilippo & Son analysis,...
Get the latest John B Sanfilippo Son food industry news, analysis, comment pieces and market research reports with just-foods company profile pages.
SAUPAN004467000 - AureoWiki
Staphylococcus aureus; pan ID: SAUPAN004467000; products: autolysin, N-acetylmuramoyl-L-alanine amidase, mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, beta-N-acetylglucosaminidase, putative, exported protein, family 4 N-acetylmuramoyl-L-alanine amidase, mannosyl-glycoendo-beta-N-acetylglucosaminidase family protein, mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase, mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase family protein, mannosyl-glycoprotein endo-beta-N-glucosaminidase, peptidoglycan endo-beta-N-acetylglucosaminidase
Dynamic Interplay between O-Linked N-Acetylglucosaminylation and Glycogen Synthase Kinase-3-dependent Phosphorylation |...
O-GlcNAc1 is a dynamically regulated post-translational modification (PTM), in which a β-N-acetylglucosamine moiety is attached to hydroxyl side chains of serine or threonine residues of proteins by O-GlcNAc-transferase (1) and removed by β-N-acetylglucosaminidase (O-GlcNAcase) (2). O-GlcNAc is ubiquitous on nuclear and cytoplasmic proteins in all multicellular eukaryotes (3). Dynamic O-GlcNAcylation plays critical roles in signal transduction (4), transcriptional control (5, 6), cell cycle regulation (7), protein degradation (8), neurodegeneration (9), and stress responses (10). Abnormally regulated O-GlcNAcylation has been found in diseases such as diabetes (11) and Alzheimer disease (12).. The role of O-GlcNAcylation in signal transduction is at least in part related to its competitive interplay with O-phosphorylation. Some of the known O-GlcNAc sites are the same as or adjacent to phosphorylation sites. For example, O-GlcNAc is reciprocal to O-phosphorylation on the C-terminal domain of ...
Reactome | MPS IIID - Sanfilippo syndrome D
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Gene Therapy Has Potential to Treat Underlying Cause of Sanfilippo, Review Study Finds
Gene therapy shows potential to effectively target the underlying cause of Sanfilippo syndrome and delay or prevent neurodegeneration, a review study finds.
Student Biotechnology Network | Events | Building Biotech - Inspiring Innovators and Growing the Bioeconomy
Building Biotech is a semi-formal event hosted at the beautiful Hyatt Regency Vancouver. Students will have the opportunity to hear about exciting developments in biotechnology while networking with industry leaders in an intimate dinner setting. Join other students and industry professionals to find the tools and resources essential to starting your career, information about emerging trends in bioenergy, and the personal paths to success taken by two pairs of local entrepreneurs.. To kick-off our new season, the SBN is excited to present Building Biotech: Inspiring Innovators and Building the Bioeconomy, with keynote speaker Dr. Ernie McEachern, the CEO and co-founder of Alectos Therapeutics Inc. Alectos Therapeutics Inc. has recently announced a research collaboration with Merck to identify and develop compounds that modulate O-linked N-acetylglucosaminidase (O-GlcNAcase), an enzyme that is believed to be involved in the development of Alzheimers disease. Other speakers include Drs. Euan ...
N ac beta glucosaminidase Dictionary Definition and More from Dictionary.net
ˈɛn ˌe͡ɪsˈiː bˈiːtə ɡlˈuːkəsˌamɪnˌɪde͡ɪs], [ˈɛn ˌeɪsˈiː bˈiːtə ɡlˈuːkəsˌamɪnˌɪdeɪs], [ˈɛ_n ˌeɪ_s_ˈiː b_ˈiː_t_ə ɡ_l_ˈuː_k_ə_s_ˌa_m_ɪ_n_ˌɪ_d_eɪ_s] ...
OriGene -Protein Listing By Pathway/Family
An alternative microRNA-mediated post-transcriptional regulation of GADD45A by p53 in human non-small-cell lung cancer cells Sci Rep 2017 [AGO2 ...
OriGene -Protein Listing By Pathway/Family
Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease Bioorg. Med. Chem. Lett. 2017 [ENGASE ...
2016) Neurological Correction of Mucopolysaccharidosis IIIB Mice by Haematopoietic Stem Cell Gene Therapy. In: 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 04 May 2016 - 07 May 2016, Washington, DC. ...
About Sanfilippo - Cure Sanfilippo Foundation
Our children are born with a genetic defect passed on from each parent that results in their body being unable to break down and recycle natural cellular waste due to a missing enzyme. Because the waste isnt broken down, it builds up in their brains, taking away all their skills and knowledge until they pass away in their early teens.
anti-NAGase antibody | Rabbit anti-Rat N-Acetyl Beta-D-Glucosaminidase (NAGase) Polyclonal Antibody-NP 571979.1
Buy anti-NAGase antibody, Rabbit anti-Rat N-Acetyl Beta-D-Glucosaminidase (NAGase) Polyclonal Antibody-NP_571979.1 (MBS2001439) product datasheet at MyBioSource, Primary Antibodies. Application: Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
SoftIntegration and NAG Release Ch NAG Statistics Package
SoftIntegration and NAG Release Ch NAG Statistics Package DAVIS, Calif., July 14, 2003 - SoftIntegration, Inc. and the Numerical Algorithms Group (NAG) announce the release of Ch NAG Statistics Package version 1.0. Designed to meet the needs of a wide range of researchers seeking rapid statistical application development, the Ch NAG Statistics Package makes a set of the robust NAG statistical routines available to users of Ch, an embeddable C/C++ interpreter for cross-platform scripting, shell programming, 2D/3D plotting, numerical computing, and embedded scripting. Ch NAG Statistics Package makes the rigorously tested statistical routines in the NAG C library available to Ch users without traditional coding and linking. This comprehensive selection of statistical routines can readily use the 2D/3D graphical plotting capabilities of Ch. In addition, with SoftIntegrations free Ch ODBC and Ch CGI toolkit, it is easy to integrate with databases and create web-based applications for statistical ...
Kidney Disease Treatment www.kidney-support.org: Why dehydration occurs in renal failure
Underlying conditions that cause dehydration should also be treated with proper treatment. If dehydration is caused by renal tubular damage or vomiting, then for the treatment of renal failure it is necessary and important. If you are interested in the treatment of renal failure. If you have any questions, please comment below, email or live chat. Our mailbox is [email protected] ...
OPUS Würzburg | Search
The growing number of uncharacterised sequences in public databases has turned the prediction of protein function into a challenging research field. Traditional annotation methods are often error-prone due to the small subset of proteins with experimentally verified function. Goal of this thesis was to analyse the function and evolution of protein domains in order to understand molecular processes in the cell. The focus was on signalling domains of little understood function, as well as on functional sites of protein domains in general. Glucosaminidases (GlcNAcases) represent key enzymes in signal transduction pathways. Together with glucosamine transferases, they serve as molecular switches, similar to kinases and phosphatases. Little was known about the molecular function and structure of the GlcNAcases. In this thesis, the GlcNAcases were identified as remote homologues of N-acetyltransferases. By comparing the homologous sequences, I was able to predict functional sites of the GlcNAcase ...
What Is An Example Of A Genetic Disease
Sanfilippo Childrens Foundation What is Sanfilippo? - This paper focuses on the causation of diseases, particularly on the idea of a вЂњgenetic causeвЂќ taking AlzheimerвЂ™s Disease (AD) as an example. We (1) provide
Lies: Dario Sanfilippo | Fluid Radio
After going into detail about Dario Sanfilippos working process during a recent Postcard From Italy article it was great to catch him playing live in the San Lorenzo district of Rome at a recent Prove Tecniche di Trasmissione event.
glycosidase: Definition, Word Game Analysis
glycosidase Definition, glycosidase Best Plays of glycosidase in Scrabble® and Words With Friends, Length tables of words in glycosidase, Word growth of glycosidase, Sequences of glycosidase
Unit III B: Neural Control and Co-ordination, Nervous System in Human Beings - Central Nervous System, Peripheral Nervous...
నెల్లూరు: మనుబోలు మండలం బద్వేలు క్రాస్రోడ్డు దగ్గర కారు బోల్తా, ముగ్గురికి గాయాలు,కర్నూలు: 16 వ రోజు జగన్ ప్రజా సంకల్ప యాత్ర,రంగారెడ్డి: మైలార్దేవ్పల్లిలో కింగ్స్ కాలనీలో ముస్తఫా అనే వ్యక్తిపై దుండగుల కాల్పులు,కడప: జగన్ సీఎం అయితే తన ఆస్తులు పెరుగుతాయి..చంద్రబాబు సీఎంగా ఉంటే ప్రజల ఆస్తులు పెరుగుతాయి: మంత్రి సోమిరెడ్డి,సిరిసిల్ల: అన్ని గ్రామాల్లో కేసీఆర్ గ్రామీణ ప్రగతి ...
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Ротация логов Radius? - Программное обеспечение, биллинг и *unix системы - Форумы NAG.RU
Собственно сабж.. FreeBSD 6.3, FreeRadius 1.1.7. newsyslog не предлагать - вешает радиус намертво.. :(
Further evidence of a hyperactive ?-N-acetylglucosaminidase-producing allele". Clinical Genetics. 41 (5): 243-247. doi:10.1111/ ...
N-acetylglucosaminidase, alpha is a protein that in humans is encoded by the NAGLU gene. This gene encodes an enzyme that ... "Entrez Gene: N-acetylglucosaminidase, alpha". Weber B, Blanch L, Clements PR, Scott HS, Hopwood JJ (June 1996). "Cloning and ... "Purification and partial characterization of alpha-N-acetylglucosaminidase from human liver". Journal of Biochemistry. 110 (5 ...
... alpha-N-acetylglucosaminidase (type B; MIM 252920); acetyl CoA:alpha-glucosaminide acetyltransferase (type C; MIM 252930); and ...
N-Acetylglucosaminidase: Experimentally found within mouse cortical granules, N-Acetylglucosaminidase is a glycosidase that ... Therefore, N-Acetylglucosaminidase contributes to polyspermy prevention. p32: The name, p32, refers to the protein's molecular ...
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene. ... "Entrez Gene: NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". Lee, W. S.; Kang, C.; Drayna, D.; ... "Purification and characterization of human serum N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". Arch. ... "Purification and characterization of human lymphoblast N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". ...
Brunner K, Peterbauer CK, Mach RL, Lorito M, Zeilinger S, Kubicek CP (July 2003). "The Nag1 N-acetylglucosaminidase of ... The regulation of an endochitinase in Trichoderma atroviride is dependent on a N-acetylglucosaminidase, and the data indicates ... Family 20 includes N-acetylglucosaminidase and a similar enzyme, N-acetylhexosaminidase. And as the gene sequences of the ... β-1,4- N-acetylglucosaminidases (EC 188.8.131.52) split the multimer products, such as di-acetylchitobiose, chitotriose, and ...
... produces endo-β-N-acetylglucosaminidase mithramycin, amicetin, bamicetin and plicacetin. Ehrenfreund, P ... "High-level expression of endo-β-N-acetylglucosaminidase H from Streptomyces plicatus in Pichia pastoris and its application for ...
Sanfilippo B is caused by the missing or deficient enzyme alpha-N-acetylglucosaminidase. Sanfilippo C results from the missing ...
... cytosolic beta-N-acetylglucosaminidase from human brain". The Journal of Biological Chemistry. 276 (13): 9838-45. doi:10.1074/ ... cytosolic beta-N-acetylglucosaminidase from human brain". The Journal of Biological Chemistry. 276 (13): 9838-45. doi:10.1074/ ... "Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes ... further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase". The Journal of Biological ...
... beta-N-acetylglucosaminidase, and beta-N-acetylgalactosaminidase from calf brain". Biochemistry. 6 (9): 2775-82. doi:10.1021/ ...
Tachibana Y, Yamashita K, Kobata A (1982). "Substrate specificity of mammalian endo-beta-N-acetylglucosaminidase: study with ...
... endo-beta-N-acetylglucosaminidase D, endo-beta-N-acetylglucosaminidase F, endo-beta-N-acetylglucosaminidase H, endo-beta-N- ... di-N-acetylchitobiosyl beta-N-acetylglucosaminidase, endo-beta-acetylglucosaminidase, endo-beta-(1->4)-N-acetylglucosaminidase ... Chien S, Weinburg R, Li S, Li Y (1977). "Endo-β-N-acetylglucosaminidase from fig latex". Biochem. Biophys. Res. Commun. 76: 317 ... The enzyme Endoglycosidase H (EC 184.108.40.206, Endo-β-N-acetylglucosaminidase H, N,N'-diacetylchitobiosyl beta-N- ...
Glycoside hydrolase family 89
Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate. Mutations on the ... Glycoside hydrolase family 89 CAZY GH_89 includes enzymes with α-N-acetylglucosaminidase EC 220.127.116.11 activity. The enzyme ... "Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase". ... alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B ...
Frohwein YZ, Gatt S (September 1967). "Isolation of β-N-acetylhexosaminidase, β-N-acetylglucosaminidase, and β-N- ... cytosolic beta-N-acetylglucosaminidase from human brain". J. Biol. Chem. 276 (13): 9838-45. doi:10.1074/jbc.M010420200. PMID ... beta-N-acetylglucosaminidase, hexosaminidase A, N-acetylhexosaminidase, beta-D-hexosaminidase) is an enzyme involved in the ... for β-N-acetylglucosaminidase, β-N-acetylhexosaminidase and β-N-acetylgalactosaminidase". Biochem. J. 261 (3): 1059-60. doi: ...
Glycoside hydrolase family 73
... CAZY GH_73 includes peptidoglycan hydrolases with endo-β-N-acetylglucosaminidase specificity. ...
NAGLU: N-acetyl glucosaminidase, Sanfilippo B syndrome (17q21.2). *SLC4A1: Band 3 anion transporter protein. Solute carrier ...
"The structure of hyperthermophilic β-N-acetylglucosaminidase reveals a novel dimer architecture associated with the active site ...
Glycoside hydrolase family 85
... enzymes have endo-beta-N-acetylglucosaminidase activity EC 18.104.22.168 (CAZY GH_85). These enzymes ...
"The Nag1 N-acetylglucosaminidase of Trichoderma atroviride is essential for chitinase induction by chitin and of major ...
... and β-N-acetylglucosaminidase. Shell membrane is mainly used as a dietary supplement in a partially hydrolyzed powder form ...
β-N-Acetylglucosaminidase (from Streptococcus pneumoniae): cleaves all non-reducing terminal β-linked N-acetylglucosamine ...
Alfa-N-acetilglukozaminidaza - Википедија, слободна енциклопедија
von Figura, K. (1977). „Human α-N-acetylglucosaminidase. 1. Purification and properties". Eur. J. Biochem. 80: 523-533. PMID ... von Figura, K. (1977). „Human α-N-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms ... Weissmann, B., Rowen, G., Marshall, J. and Friederici, D. (1967). „Mammalian α-acetylglucosaminidase. Enzymic properties, ...
... produces secalonic acid D, chitinase, oxalic acid, oxaline and β-N-acetylglucosaminidase and occurs ...
CBM32 modules are associated with catalytic modules such as sialidases, B-N-acetylglucosaminidases, α-N-acetylglucosaminidases ...
... of a cosmid from a gene-rich region in 17q21 and characterization of a candidate gene for alpha-N-acetylglucosaminidase with ...
... s (chitodextrinase, 1,4-beta-poly-N-acetylglucosaminidase, poly-beta-glucosaminidase, beta-1,4-poly-N-acetyl ... The regulation of an endochitinase in Trichoderma atroviride is dependent on a N-acetylglucosaminidase, and the data indicates ... β-1,4- N-acetylglucosaminidases (EC 22.214.171.124) split the multimer products, such as di-acetylchitobiose, chitotriose, and ... Family 20 includes N-acetylglucosaminidase and a similar enzyme, N-acetylhexosaminidase. ...
List of MeSH codes (D08)
... acetylglucosaminidase MeSH D08.811.277.450.483.044 - alpha-N-acetylgalactosaminidase MeSH D08.811.277.450.483.112 - Beta-N- ... Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MeSH D08.811.277.450.529 - hyaluronoglucosaminidase MeSH D08.811. ...
List of EC numbers (EC 3)
... α-N-acetylglucosaminidase EC 126.96.36.199: a-L-fucosidase EC 188.8.131.52: b-L-N-acetylhexosaminidase EC 184.108.40.206: b-N- ... b-aspartyl-N-acetylglucosaminidase EC 220.127.116.11: inosinate nucleosidase EC 18.104.22.168: 1-methyladenosine nucleosidase EC 22.214.171.124 ... mannosyl-glycoprotein endo-b-N-acetylglucosaminidase EC 126.96.36.199: glycopeptide a-N-acetylgalactosaminidase EC 188.8.131.52: glucan ... N-acetylglucosamine-1-phosphodiester a-N-acetylglucosaminidase EC 184.108.40.206: glycerophosphodiester phosphodiesterase EC 220.127.116.11 ...
... β-N-acetylglucosaminidase β-D-fucosidase α-galactosidase β-glucuronidase pyrrolidonylarylamidase sialidase Normally found in ... β-N-acetylgalactosaminidase β-D-fucosidase α-galactosidase α-glucosidase β-glucosdiase β-N-acetylglucosaminidase Most strains ...
Heme oxygenase HemO and N-acetylglucosaminidases Genes encoding transport proteins Genes involved in carbohydrate metabolism ...
Alpha-N-acetylglucosaminidase - Wikipedia
Alpha-N-acetylglucosaminidase (EC 18.104.22.168, alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha- ... von Figura K (November 1977). "Human alpha-N-acetylglucosaminidase. 1. Purification and properties". European Journal of ... von Figura K (November 1977). "Human alpha-n-acetylglucosaminidase. 2. Activity towards natural substrates and multiple ... Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). "Mammalian alpha-acetylglucosaminidase. Enzymic properties, ...
Endo-beta-n-acetylglucosaminidase - Wikipedia
Endo-beta-N-acetylglucosaminidase is a protein that in humans is encoded by the ENGASE gene. This gene encodes a cytosolic ... "Entrez Gene: Endo-beta-N-acetylglucosaminidase". Retrieved 2018-08-24. Suzuki T, Yano K, Sugimoto S, Kitajima K, Lennarz WJ, ... Butkinaree C, Cheung WD, Park S, Park K, Barber M, Hart GW (August 2008). "Characterization of beta-N-acetylglucosaminidase ... Park K, Saudek CD, Hart GW (July 2010). "Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals ...
Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activities....
Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase/chemistry*. *Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase/ ... Endo-beta-N-acetylglucosaminidase from Mucor hiemalis (Endo-M), a family 85 glycoside hydrolase, acts on the beta1,4 linkage of ... This is the first glycosynthase derived from endo-beta-N-acetylglucosaminidases that proceed via a substrate-assisted mechanism ... Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activities. ...
N-Acetylglucosaminidase, alpha (NAGLU) ELISA Kits
... alpha-N-acetylglucosaminidase , N-acetylglucosaminidase, alpha- , alpha-N-acetylglucosaminidase-like , N-acetylglucosaminidase ... N-Acetylglucosaminidase, alpha ELISA Kits 7 N-Acetylglucosaminidase, alpha (NAGLU) ELISA Kits von 5 Herstellern verfügbar auf ... Alternative names and synonyms associated with N-Acetylglucosaminidase, alpha (NAGLU) * N-acetylglucosaminidase, alpha (naglu) ... N-Acetylglucosaminidase, alpha (NAGLU) ELISA Kit ELISA Kit NAGLU Reaktivität: Maus Colorimetric Sandwich ELISA 3.125-200 ng/mL ...
Characterization of AcmB, an N-acetylglucosaminidase autolysin from Lactococcus lactis. - PubMed - NCBI
N-Acetylglucosaminidase activity, a functional trait of chitin degradation, is regulated differentially within two orders of...
N-Acetylglucosaminidase activity, a functional trait of chitin degradation, is regulated differentially within two orders of ... Because extracellular N-acetylglucosaminidase activity has been proposed as functional trait of chitin degradation, we screened ... Chitin degradation Chitinase N-Acetylglucosaminidase Functional trait Fungal phylogeny Electronic supplementary material. The ... Table S.2 Extracellular N-acetylglucosaminidase activity (pmol.ml-1.min-1) of ectomycorrhizal fungi with and without chitin in ...
N-Acetylglucosaminidase, alpha ELISA & Assay Kits
Compare and order N-Acetylglucosaminidase, alpha ELISA Kits. View citations, images, detection ranges, sensitivity, prices and ... alpha-N-acetylglucosaminidase , N-acetylglucosaminidase, alpha- , alpha-N-acetylglucosaminidase-like , N-acetylglucosaminidase ... More product categories related to N-Acetylglucosaminidase, alpha ELISA Kit * 14 N-Acetylglucosaminidase, alpha ELISA & Assay ... alpha- (Sanfilippo disease IIIB) , N-acetyl-glucosaminidase , alpha-N-acetylglucosaminidase, lysosomal , N-acetyl-alpha- ...
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Antibodies | Invitrogen ...
AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning
β-N-Acetylglucosaminidase (NAG) Activity Assay Kit | PromoCell
Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to...
β-N-Acetylglucosaminidase from Streptococcus pneumoniae, recombinant, expressed in E. coli, buffered aqueous solution pricing ... β-N-Acetylglucosaminidase from Canavalia ensiformis (Jack bean), ammonium sulfate suspension, ≥15 units/mg protein pricing ... β-N-Acetylglucosaminidase from bovine kidney, ammonium sulfate suspension, 10-50 units/mg protein pricing ... Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to ...
Endo-β-N-Acetylglucosaminidase catalysed glycosylation: tolerance of enzymes to structural variation of the glycosyl amino acid...
Endo-β-N-Acetylglucosaminidases (ENGases) are highly useful biocatalysts that can be used to synthetically access a wide ... Endo-β-N-Acetylglucosaminidases (ENGases) are highly useful biocatalysts that can be used to synthetically access a wide ... Endo-β-N-Acetylglucosaminidase catalysed glycosylation: tolerance of enzymes to structural variation of the glycosyl amino acid ... Endo-β-N-Acetylglucosaminidase catalysed glycosylation: tolerance of enzymes to structural variation of the glycosyl amino acid ...
β-N-Acetylglucosaminidase from Streptococcus pneumoniae
Endo-A - endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae | AcronymAttic
Endo-A is defined as endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae rarely. ... Endo-A stands for endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae. ... How is endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae abbreviated? ... The gene encoding endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) was cloned, and its nucleotide ...
Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 22.214.171.124) - Pipeline Review, H1 2016 | Aug 16, 2016 ...
Additionally, the report provides an overview of key players involved in Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha- ... The report provides comprehensive information on the Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC ... Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 126.96.36.199) - Pipeline Review, H1 2016. The Report ... The report reviews latest news and deals related to Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC ...
Endo-β-N-acetylglucosaminidases from Infant Gut-associated Bifidobacteria Release Complex N-glycans from Human Milk...
Distribution of Endo-N-acetylglucosaminidase Gene Sequences in Bifidobacteria. Based on known endo-N-acetylglucosaminidase ... Endo-β-N-acetylglucosaminidases were identified in certain isolates of Bifidobacterium longum subsp. longum, B. longum subsp. ... 2001) Molecular cloning and expression of endo-β-N-acetylglucosaminidase D, which acts on the core structure of complex type ... 2000) Production of an endo-β-N-acetylglucosaminidase activity mediates growth of Enterococcus faecalis on a high-mannose-type ...
Streptococcal Group a Polysaccharide Haptens: Susceptibility to Degradation by β-N-Acetylglucosaminidases and Antibody...
The activity of β-N-acetylglucosaminidase enzymes derived from the soil bacillus and from macrophage cells was assessed on the ... Both the soil bacillus and macrophage β-N-acetylglucosaminidases were effective in eliminating most of the antibody inhibitory ... Streptococcal Group a Polysaccharide Haptens: Susceptibility to Degradation by β-N-Acetylglucosaminidases and Antibody- ... Streptococcal Group a Polysaccharide Haptens: Susceptibility to Degradation by β-N-Acetylglucosaminidases and Antibody- ...
Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa
The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, ... The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, ... Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. 01-08-2017 ...
Functional analysis of AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis. - Inserm
... of peptidoglycan hydrolysis products obtained using the purified protein to show that AtlA is an N-acetylglucosaminidase. To ... Functional analysis of AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis. Catherine Eckert 1, 2 Maxime Lecerf 1 ... Functional analysis of AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis.. Journal of Bacteriology, American ... of peptidoglycan hydrolysis products obtained using the purified protein to show that AtlA is an N-acetylglucosaminidase. To ...
HDCN: Article by Navarro et al. Effects of <B>pentoxifylline</B> administration on urinary N-acetyl-- glucosaminidase...
2018-2025 Alpha N-Acetylglucosaminidase Report on Global and United States Market, Status and Forecast, by Players, Types and...
2018-2025 Alpha N-Acetylglucosaminidase Report on Global and United States Market, Status and Forecast, by Players, Types and ... Global Alpha N-Acetylglucosaminidase Sales Market Report 2018. United States Alpha N-Acetylglucosaminidase Market Report 2018. ... 10.4 Alpha N-Acetylglucosaminidase Forecast by Type. 10.4.1 Global Alpha N-Acetylglucosaminidase Sales (K Pcs) and Revenue ( ... 2.1 Alpha N-Acetylglucosaminidase Product Overview. 2.2 Alpha N-Acetylglucosaminidase Market Segment by Type. 2.2.1 Lesinidase ...
Galactosyltransferase-dependent sialylation of complex and endo-N-acetylglucosaminidase H-treated core N-glycans in vitro. -...
Galactosyltransferase-dependent sialylation of complex and endo-N-acetylglucosaminidase H-treated core N-glycans in vitro. ... Incorporation of sialic acid into endo-beta-N-acetylglucosaminidase H-treated oligomannose glycoproteins may be useful for in ... Incorporation of sialic acid into endo-beta-N-acetylglucosaminidase H-treated oligomannose glycoproteins may be useful for in ... Galactosyltransferase-dependent sialylation of complex and endo-N-acetylglucosaminidase H-treated core N-glycans in vitro. FEBS ...
Novel Cancer Vaccination System Based on Human Endo-and#914;-N-Acetyl Glucosaminidase Gene Delivery | Abstract
Carbohydrates - Analytical Research - β-N-Acetyl-Glucosaminidase
Characterization of glycosyl hydrolase family 3 beta-N-acetylglucosaminidases from Thermotoga maritima and Thermotoga...
The optimal temperatures and pHs for the activities of the beta-N-acetylglucosaminidases were found to be 65-75 degrees C and ... However, NagA and CbsA can be distinguished from other GH3-type beta-N-acetylglucosaminidases in that they are highly active ... The genes encoding beta-N-acetylglucosaminidase (nagA and cbsA) from Thermotoga maritima and Thermotoga neapolitana were cloned ... Crystal structure of β-N-acetylglucosaminidase CbsA from Thermotoga neapolitana.. *Jin-Sik Kim, B. Yoon, Jinsook Ahn, J. Cha, N ...
Beta-aspartyl-N-acetylglucosaminidase - In enzymology, a beta aspartyl N acetylglucosaminidase (EC number,188.8.131.52) is an ... Alpha-N-acetylglucosaminidase - N acetylglucosaminidase, alpha (Sanfilippo disease IIIB) Identifiers Symbol NAGLU Entrez 4669 ... α-N-acetylglucosaminidase - α N ac·e·tyl·glu·co·sa·min·i·dase (as″ə təl ) (as″ə tēl″gloo kōs″ə minґĭ dās) [EC 184.108.40.206] a ... β-D-acetylglucosaminidase - β D ac·e·tyl·glu·co·sa·min·i·dase (asґə təl ) (asґə tēl″gloo kōs″ə minґĭ dās) a lysosomal ...
β-Acetylglucosaminidase 18A from Bacteroides thetaiotaomicron, Recombinant (EC 220.127.116.11 ) - Creative Enzymes
"β-acetylglucosaminidase 18A, is an enzyme from Bacteroides thetaiotaomicron that participates in the endohydrolysis of the ... β-Acetylglucosaminidase 18A from Bacteroides thetaiotaomicron, Recombinant β-Acetylglucosaminidase 18A from Bacteroides ... β-acetylglucosaminidase 18A, is an enzyme from Bacteroides thetaiotaomicron that participates in the endohydrolysis of the ...
N-Acetylglucosaminidase - QA-Bio
N-acetylglucosaminidase References. Clarke, V. A., N. Platt and T.D. Betters. Cloning and expression of the beta-N- ... N-acetylglucosaminidase cleaves all non-reducing terminal β-linked N-acetylglucosamine residues from complex carbohydrates and ... N-acetylglucosaminidase cleaves all non-reducing terminal β-linked N-acetylglucosamine residues from complex carbohydrates and ... Purity Each lot of N-acetylglucosaminidase is tested for contaminating protease as follows; 10 μg of denatured BSA is incubated ...
Synthesis of neoglycoproteins using oligosaccharide-transfer activity with endo-β-N-acetylglucosaminidase<...
Endo-β-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) had high levels of transglycosylation activity. The ... Endo-β-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) had high levels of transglycosylation activity. The ... Endo-β-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) had high levels of transglycosylation activity. The ... Endo-β-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) had high levels of transglycosylation activity. The ...
EnzymeMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseBeta-N-acetylglucosaminidase activityCleavesIIIBSanfilippoCharacterizationEnzymesGeneEndoNAGLUOligosaccharidesDegradationBacillusActivityNagZGlycosideHydrolysisNagAAbstractMuramidase2017FungalSubstrateEncodesAlphaHumanGenesFunctionalProfilesRegulation
- β-N-Acetylglucosaminidase (NAG) is a lysosomal enzyme that is expressed in various tissues, including kidney, liver and lungs. (promocell.com)
- Both the soil bacillus and macrophage β-N-acetylglucosaminidases were effective in eliminating most of the antibody inhibitory activity of the haptens, although this was achieved at lower concentrations of the soil bacillus enzyme. (jimmunol.org)
- N-acetylglucosaminidase (ENGase), an enzyme that cleaves the amide bond between the proximal GlcNAc residues at the side chain of an asparagine residue on N-glycans, also causes exposure of GlcNAc residues on the cell surface. (longdom.org)
- β-acetylglucosaminidase 18A, is an enzyme from Bacteroides thetaiotaomicron that participates in the endohydrolysis of the diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the (Man(GlcNAc)(2))Asn-structure. (creative-enzymes.com)
- However, overproduction of the enzyme fused to TAT or Sec signal peptides led to secretion of active β-N-acetylglucosaminidase. (biomedcentral.com)
- Herein, cultures and field populations of marine phytoplankton were assayed for beta-N-acetylglucosaminidase activity, a terminal enzyme of chitin degradation. (mblwhoilibrary.org)
- N-Acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (phosphodiester α-GlcNAcase, also known as "uncovering enzyme") is a type I membrane-spanning glycoprotein enzyme of the Golgi apparatus. (wustl.edu)
- The NAGLU gene provides instructions for producing an enzyme called alpha-N-acetylglucosaminidase. (medlineplus.gov)
- Chitin degradation is catalyzed by a two-component chitinolytic enzyme system, chitinase and -N-acetylglucosaminidase (NAGase). (bireme.br)
- Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase" by people in this website by year, and whether "Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase" by people in Profiles. (uchicago.edu)
- Cell-specific beta-N-acetylglucosaminidase activity in cultures and field populations of eukaryotic marine phytoplankton. (mblwhoilibrary.org)
- beta-N-acetylglucosaminidase activity was widespread across various taxa of marine phytoplankton, and activity was observed both under controlled culture conditions and in field populations. (mblwhoilibrary.org)
- N-acetylglucosaminidase cleaves all non-reducing terminal β-linked N-acetylglucosamine residues from complex carbohydrates and glycoproteins. (qa-bio.com)
- The first gene was shown to encode a cell wall-associated β-N-acetylglucosaminidase (NagZ, formerly YbbD) that cleaves the terminal nonreducing N-acetylglucosamine of muropeptides and also accepts chromogenic or fluorogenic β-N-acetylglucosaminides. (uni-konstanz.de)
- Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts. (sigmaaldrich.com)
- All of the mutations that cause MPS IIIB reduce or eliminate the function of alpha-N-acetylglucosaminidase. (medlineplus.gov)
- Mucopolysaccharidosis Type Iiib is also known as Alpha-n-acetylglucosaminidase Deficiency, Mps Iii B, Mps Iiib, N-acetyl-alpha-d-glucosaminidase Deficiency, Naglu Deficiency. (novusbio.com)
- Alpha-N-acetylglucosaminidase (EC 18.104.22.168, alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, alpha-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome. (wikipedia.org)
- also known as Sanfilippo B syndrome) has been hindered by inadequate mannose 6 phosphorylation and cellular uptake of rhNAGLU (recombinant human α-N-acetylglucosaminidase). (sigmaaldrich.com)
- Deficiency of alpha- N -acetylglucosaminidase is diagnostic for Sanfilippo syndrome type B. (testcatalog.org)
- Characterization of AcmB, an N-acetylglucosaminidase autolysin from Lactococcus lactis. (nih.gov)
- Characterization of glycosyl hydrolase family 3 beta-N-acetylglucosaminidases from Thermotoga maritima and Thermotoga neapolitana. (semanticscholar.org)
- Biochemical characterization of the first fungal glycoside hydrolyase family 3 β-N-acetylglucosaminidase from Rhizomucor miehei. (semanticscholar.org)
- Biochemical characterization and structural analysis of a β-N-acetylglucosaminidase from Paenibacillus barengoltzii for efficient production of N-acetyl-D-glucosamine. (semanticscholar.org)
- Molecular characterization and function of -N-acetylglucosaminidase from ridgetail white prawn Exopalaemon carinicauda. (bireme.br)
- The activity of β-N-acetylglucosaminidase enzymes derived from the soil bacillus and from macrophage cells was assessed on the various haptens. (jimmunol.org)
- The 'profile' of the epidermal glycosidases is significantly different from that reported for whole skin, the activities of beta-galactosidase and beta-acetylglucosaminidase being very high and those of the remaining enzymes relatively low in epidermis. (nih.gov)
- Through studies on a representative member, the Nag3 beta-N-acetylglucosaminidase from Cellulomonas fimi, we now show that these enzymes act preferentially as glycoside phosphorylases. (ubc.ca)
- O -GlcNAcylation is orchestrated by two opposing enzymes, O -GlcNAc transferase and OGA ( O -GlcNAcase or β-N-acetylglucosaminidase), which recognize their target proteins via as yet unidentified mechanisms. (biochemj.org)
- Endo-beta-N-acetylglucosaminidase is a protein that in humans is encoded by the ENGASE gene. (wikipedia.org)
- The gene encoding endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) was cloned, and its nucleotide sequence was determined. (acronymattic.com)
- Cloning and expression of the beta-N-acetylglucosaminidase gene from Steptococcus pneumoniae . (qa-bio.com)
- The nagA 2 gene product was active as β-N-acetylglucosaminidase with 0.27 mM 4-nitrophenyl N,N'-diacetyl-β-D-chitobioside as substrate supporting half-maximal activity. (biomedcentral.com)
- Recent studies have shown that the fused lobes (fdl) gene encodes the specific, processing β-N-acetylglucosaminidase of Drosophila melanogaster. (core.ac.uk)
- One has suggested that a gene alternatively designated SfGlcNAcase-3 or SfHex encodes this function, whereas another has suggested that this gene encodes a broad-spectrum β-N-acetylglucosaminidase that functions in glycan and chitin degradation. (core.ac.uk)
- Moreover, we showed that the endogenous levels of specific, processing β-N-acetylglucosaminidase activity were significantly reduced in S. frugiperda cells engineered to express a double-stranded RNA derived from the Sf-fdl gene. (core.ac.uk)
- Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activities. (nih.gov)
- Endo-beta-N-acetylglucosaminidase from Mucor hiemalis (Endo-M), a family 85 glycoside hydrolase, acts on the beta1,4 linkage of N,N'-diacetylchitobiose moiety in the N-linked glycans of glycoproteins and catalyzes not only the hydrolysis reaction but also the transglycosylation reaction that transfers the releasing sugar chain to an acceptor other than water to form a new glycosidic linkage. (nih.gov)
- This is the first glycosynthase derived from endo-beta-N-acetylglucosaminidases that proceed via a substrate-assisted mechanism. (nih.gov)
- Endo -β- N -Acetylglucosaminidases (ENGases) are highly useful biocatalysts that can be used to synthetically access a wide variety of defined homogenous N-linked glycoconjugates in a convergent manner. (rsc.org)
- Endo-β- N -acetylglucosaminidases were identified in certain isolates of Bifidobacterium longum subsp. (mcponline.org)
- Galactosyltransferase-dependent sialylation of complex and endo-N-acetylglucosaminidase H-treated core N-glycans in vitro. (uzh.ch)
- Purified beta-N-acetylglucosaminide beta(1-4)galactosyltransferase and partially purified beta-galactoside alpha(2-6)-sialyltransferase were used to elongate and terminate glycan chains of agalacto-ovalbumin and endo-beta-N-acetylglucosaminidase H-treated yeast invertase in vitro. (uzh.ch)
- Incorporation of sialic acid into endo-beta-N-acetylglucosaminidase H-treated oligomannose glycoproteins may be useful for in vivo stabilization of these glycoproteins by preventing uptake in liver or reticuloendothelial cells. (uzh.ch)
- Endo-β-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) had high levels of transglycosylation activity. (elsevier.com)
- Selective cleavage by endo-beta-N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoproteins. (uchicago.edu)
- Kimura, Y 2009, ' Suppression of endo-beta-N-acetylglucosaminidase and peptide+N-glycanase activity in Arabidopsis thaliana ', 15th European Carbohydrate Symposium Abstract , vol. 15, pp. 531-531. (elsevier.com)
- Arthrobacter endo-β-N-acetylglucosaminidase (Endo-A), a member of glycoside hydrolase (GH) family 85, catalyses the hydrolysis and transglycosylation of asparagine-linked oligosaccharides of glycoproteins with retention of anomeric configuration. (elsevier.com)
- Furthermore, the produced β-glycosyl azide (Man 5 GlcNAc-β-N 3 ) retained the anomeric configuration, indicating that Glu-173 is the catalytic acid-base residue of Endo-A. This is the first identification of the catalytic residue for GH family 85 endo-β-N-acetylglucosaminidases. (elsevier.com)
- 7 N-Acetylglucosaminidase, alpha (NAGLU) ELISA Kits von 5 Herstellern verfügbar auf www.antikoerper-online.de. (antikoerper-online.de)
- N-acetylglucosaminidase Acting Complex Asparagine-Linked Oligosaccharides. (nii.ac.jp)
- Because extracellular N-acetylglucosaminidase activity has been proposed as functional trait of chitin degradation, we screened this activity on 35 EM fungi species with or without chitin in the growth medium to (i) describe the functional diversity of EM fungi and (ii) identify potential links between this functional trait and EM fungal phylogeny. (springer.com)
- The active site domain is homologous to that of muramidase-2 of Enterococcus hirae, however, RP-HPLC analysis of muropeptides released from Bacillus subtilis peptidoglycan, after digestion with AcmA, shows that AcmA is an N-acetylglucosaminidase. (nih.gov)
- In the wild type, β-N-acetylglucosaminidase activity was too low to be detected. (biomedcentral.com)
- Measurement of alpha-N-acetylglucosaminidase activity is not the preferred diagnostic test for I-cell disease but may be included in the testing strategy. (testcatalog.org)
- The lack of alpha-N-acetylglucosaminidase activity disrupts the breakdown of a subset of GAGs called heparan sulfate. (medlineplus.gov)
- N-acetylglucosaminidase activity and diabetic retinopathy - observed for 2 years. (nii.ac.jp)
- N-acetylglucosaminidase activity in experimental and clinical diabetes mellitus. (nii.ac.jp)
- The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, cell-wall-derived natural products. (sebbm.es)
- NagZ de Pseudomonas aeruginosa cataliza el primer paso del reciclaje de los muropéptidos (fragmentos naturales de la pared bacteriana) en el citoplasma y regula la expresión de la -lactamasa, la enzima clave en la resistencia a antibióticos -lactámicos. (sebbm.es)
- El trabajo proporciona una imagen de todos los pasos del ciclo catalítico de NagZ en este importante patógeno humano. (sebbm.es)
- The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, and regulates β-lactam resistance. (biofisica.info)
- CAZy glycoside hydrolase family GH3 consists primarily of stereochemistry-retaining beta-glucosidases but also contains a subfamily of beta-N-acetylglucosaminidases. (ubc.ca)
- We have used tandem mass spectrometry analysis of peptidoglycan hydrolysis products obtained using the purified protein to show that AtlA is an N-acetylglucosaminidase. (inserm.fr)
- By means of transglycosylation, (Man) 6 GlcNAc was transferred en bloc to the partially deglycosylated ovalbumin glycopeptide (EEKYN(GlcNAc) LTSVL) concomitant with the hydrolysis of (Man) 6 (GlcNAc) 2 Asn. (elsevier.com)
- The genes encoding beta-N-acetylglucosaminidase (nagA and cbsA) from Thermotoga maritima and Thermotoga neapolitana were cloned and expressed in Escherichia coli in order to investigate whether Thermotoga sp. (semanticscholar.org)
- Abstractβ-N-Acetylglucosaminidases (GlcNAcases) are important for many biological functions and industrial applications. (semanticscholar.org)
- abstract = "The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of beta-N-acetylglucosaminidases are described. (edu.au)
- Though showing sequence similarity with enterococcal muramidase, AcmB has N-acetylglucosaminidase specificity. (nih.gov)
- The global Alpha N-Acetylglucosaminidase market is valued at XX million USD in 2017 and is expected to reach XX million USD by the end of 2025, growing at a CAGR of XX% between 2017 and 2025. (rnrmarketresearch.com)
- We observed large variations of the extracellular N-acetylglucosaminidase activities among the fungal strains. (springer.com)
- In this study we resolved this conflict by molecularly cloning an S. frugiperda fdl ortholog (Sf-fdl) and demonstrating that it encodes a product with the substrate specificity expected of the processing β-N-acetylglucosaminidase. (core.ac.uk)
- However, its genome encodes a putative N-acetylglucosaminidase. (biomedcentral.com)
- Human alpha-N-acetylglucosaminidase. (wikipedia.org)
- Mammalian alpha-acetylglucosaminidase. (wikipedia.org)
- The Report Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 22.214.171.124) - Pipeline Review, H1 2016 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. (sbwire.com)
- Albany, NY -- ( SBWIRE ) -- 08/16/2016 -- Global Markets Directs, Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 126.96.36.199) - Pipeline Review, H1 2016, provides in depth analysis on Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 188.8.131.52) targeted pipeline therapeutics. (sbwire.com)
- The report provides comprehensive information on the Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 184.108.40.206), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (sbwire.com)
- Additionally, the report provides an overview of key players involved in Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 220.127.116.11) targeted therapeutics development and features dormant and discontinued projects. (sbwire.com)
- this report analyzes the top players in global and United States market, and splits the Alpha N-Acetylglucosaminidase market by product type and application/end industries. (rnrmarketresearch.com)
- Any changes from United States might affect the development trend of Alpha N-Acetylglucosaminidase. (rnrmarketresearch.com)
- Patients with Mucolipidosis II/III (I-cell disease) may demonstrate elevations of alpha-N-acetylglucosaminidase in addition to abnormalities of other hydrolases. (testcatalog.org)
- Alpha-N-acetylglucosaminidase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). (medlineplus.gov)
- Alpha-N-acetylglucosaminidase removes a sugar called N-acetylglucosamine when it is at the end of the GAG chain. (medlineplus.gov)
- People with this type are missing or do not produce enough alpha- N -acetylglucosaminidase. (medlineplus.gov)
- The compound is a good inhibitor of both human O-GlcNAcase and human beta-hexosaminidase, as well as two bacterial beta-N-acetylglucosaminidases. (edu.au)
- Both the OGT ( O -GlcNAc transferase) and its antagonistic OGA ( O -GlcNAcase or β-N-acetylglucosaminidase) are encoded by single genes in metazoa [ 11 , 12 ]. (biochemj.org)
- Functional analysis of AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis. (inserm.fr)
- These profiles of extracellular N-acetylglucosaminidase stimulation/repression might be conserved at a high phylogenetic level in the Basidiomycota phylum, as illustrated by the opposite patterns of regulation between Boletales and Agaricales. (springer.com)
- Furthermore, our results revealed two regulation patterns of extracellular N-acetylglucosaminidase activities. (springer.com)