Acetylglucosaminidase
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
An improved method for the structural profiling of keratan sulfates: analysis of keratan sulfates from brain and ovarian tumors. (1/982)
A previously developed method for the structural fingerprinting of keratan sulfates (Brown et al., Glycobiology, 5, 311-317, 1995) has been adapted for use with oligosaccharides fluorescently labeled with 2-aminobenzoic acid following keratanase II digestion. The oligosaccharides are separated by high-pH anion-exchange chromatography on a Dionex AS4A-SC column. This methodology permits quantitative analysis of labeled oligosaccharides which can be detected at the sub-nanogram ( approximately 100 fmol) level. Satisfactory calibration of this method can be achieved using commercial keratan sulfate standards. Keratan sulfates from porcine brain phosphocan and human ovarian tumors have been examined using this methodology, and their structural features are discussed. (+info)Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats. (2/982)
Evidence for temporal variation in the nephrotoxicity of amphotericin B was recently reported in experimental animals. The role of food in these variations was determined by studying the effect of a short fasting period on the temporal variation in the renal toxicity of amphotericin B. Twenty-eight normally fed and 28 fasted female Sprague-Dawley rats were used. Food was available ad libitum to the fed rats, while the fasted animals were fasted 12 h before and 24 h after amphotericin B injection to minimize stress for the animals. Water was available ad libitum to both groups of rats, which were maintained on a 14-h light, 10-h dark regimen (light on at 0600 h). Renal toxicity was determined by comparing the levels of excretion of renal enzyme and the serum creatinine and blood urea nitrogen (BUN) levels at the time of the maximal (0700 h) or the minimal (1900 h) nephrotoxicity after the intraperitoneal administration of a single dose of dextrose (5%; control group) or amphotericin B (50 mg/kg of body weight; treated group) to the rats. The nephrotoxicities obtained after amphotericin B administration at both times of day were compared to the nephrotoxicities observed for time-matched controls. In fed animals, the 24-h urinary excretion of N-acetyl-beta-D-glucosaminidase and beta-galactosidase was significantly higher when amphotericin B was injected at 0700 and 1900 h. The excretion of these two enzymes was reduced significantly (P < 0.05) in fasting rats, and this effect was larger at 0700 h (P < 0.05) than at 1900 h. The serum creatinine level was also significantly higher (P < 0.05) in fed animals treated at 0700 h than in fed animals treated at 1900 h. Fasting reduced significantly (P < 0.05) the increase in the serum creatinine level, and this effect was larger in the animals treated at 0700 h. Similar data were obtained for BUN levels. Amphotericin B accumulation was significantly higher (P < 0.05) in the renal cortexes of fed rats than in those of fasted animals, but there was no difference according to the time of injection. These results demonstrated that fasting reduces the nephrotoxicity of amphotericin B and that food availability is of crucial importance in the temporal variation in the renal toxicity of amphotericin B in rats. (+info)Endometrial lysosomal enzyme activity in normal cycling endometrium. (3/982)
The objective of this study was to evaluate the possible role of four lysosomal enzymes in endometrial function and remodelling during the normal menstrual cycle by fluorimetric measurement (acid phosphatase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase). A prospective study was conducted of 45 endometrial biopsies obtained from women with normal menstrual cycles. Activity of all four enzymes was identified in human endometrium. Activity of acid phosphatase and N-acetyl-beta-D-glucosaminidase was relatively high, whilst that of alpha-L-fucosidase and alpha-D-mannosidase was low. There was no significant change in the activity of any of the four enzymes from the proliferative to the secretory phase of the cycle. This study suggests that the activity of these enzymes remains constant throughout a major portion of the normal cycle. (+info)Immediate and early renal function after living donor transplantation. (4/982)
BACKGROUND: In order to assess the immediate renal function after living donor transplantation, renal function was compared in eight renal allograft recipients and their living related kidney donors during the first 24 h after transplantation. METHODS: Substantial and comparable intraoperative volume loading with Ringer's acetate and mannitol was performed together with the administration of frusemide. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were estimated by the clearances of inulin and p-aminohippurane, respectively. Tubular reabsorptive function and injury were estimated from the clearance of lithium, the fractional excretion of sodium and the urinary excretion of N-acetyl-beta-glucosaminidase. RESULTS: One hour after completion of surgery, GFR (54 +/- 7 ml/min) and ERPF (294 +/- 35 ml/min) were only 30% lower in the grafts than in the remaining donor kidneys, increasing to similar levels within 3 h. Only minor tubular dysfunction and injury were revealed in the grafted kidneys, and these tended to normalize within 24 h. CONCLUSIONS: By the present transplantation procedure comprising short ischaemia time and substantial volume expansion combined with mannitol and frusemide administration, kidneys from living donors regain nearly normal function within a few hours after transplantation. (+info)Active site characterization of the exo-N-acetyl-beta-D- glucosaminidase from thermotolerant Bacillus sp. NCIM 5120: involvement of tryptophan, histidine and carboxylate residues in catalytic activity. (5/982)
The exo-N-acetyl-beta-d-glucosaminidase (EC 3.2.1.30) from thermotolerant Bacillus sp. NCIM 5120 is a homotetramer with a molecular mass of 240000 kDa. Chemical modification studies on the purified exo-N-acetyl-beta-d-glucosaminidase revealed the involvement of a single tryptophan, histidine and carboxylate, per monomer, in the catalytic activity of the enzyme. Spectral analysis and maintenance of total enzyme activities indicated that N-acetylglucosamine (competitive inhibitor) and p-nitrophenyl-N-acetyl-beta-d-glucosaminide (substrate) prevented the modification of a single essential tryptophan, histidine and carboxylate residue. Kinetic parameters of partially inactivated enzyme (by NBS/HNBB) showed the involvement of tryptophan in substrate binding while that of histidine (by photooxidation/DEPC) and carboxylate (by EDAC/WRK) in catalysis. The Bacillus sp. NCIM 5120 exo-N-acetyl-beta-d-glucosaminidase deviates from the reported N-acetyl-beta-d-glucosaminidases and beta-hexosaminidases that utilize anchimeric assistance in their hydrolytic mechanism. (+info)Sanfilippo type B syndrome (mucopolysaccharidosis III B): allelic heterogeneity corresponds to the wide spectrum of clinical phenotypes. (6/982)
Sanfilippo B syndrome (mucopolysaccharidosis IIIB, MPS IIIB) is caused by a deficiency of alpha-N-acetylglucosaminidase, a lysosomal enzyme involved in the degradation of heparan sulphate. Accumulation of the substrate in lysosomes leads to degeneration of the central nervous system with progressive dementia often combined with hyperactivity and aggressive behaviour. Age of onset and rate of progression vary considerably, whilst diagnosis is often delayed due to the absence of the pronounced skeletal changes observed in other mucopolysaccharidoses. Cloning of the gene and cDNA encoding alpha-N-acetylglucosaminidase enabled a study of the molecular basis of this syndrome. We were able to identify 31 mutations, 25 of them novel, and two polymorphisms in the 40 patients mostly of Australasian and Dutch origin included in this study. The observed allellic heterogeneity reflects the wide spectrum of clinical phenotypes reported for MPS IIIB patients. The majority of changes are missense mutations; also four nonsense and nine frameshift mutations caused by insertions or deletions were identified. Only five mutations were found in more than one patient and the observed frequencies are well below those observed for the common mutations in MPS IIIA. R643C and R297X each account for around 20% of MPS IIIB alleles in the Dutch patient group, whilst R297X, P521L, R565W and R626X each have a frequency of about 6% in Australasian patients. R643C seems to be a Dutch MPS IIIB allele and clearly confers the attenuated phenotype. One region of the gene shows a higher concentration of mutations, probably reflecting the instability of this area which contains a direct repeat. Several arginine residues seem to be 'hot-spots' for mutations, being affected by two or three individual base pair exchanges. (+info)Effect of age on urinary excretion of N-acetyl-beta-D-glucosaminidase. (7/982)
To examine the relationship between the concentrations of urinary NAG and age, we measured ratios of urinary N-acetyl-beta-D-glucosaminidase (NAG) to urinary creatinine (NAG index) in 137 healthy subjects, aged from 19 to 88 years. The study is also designed to evaluate the relationship between urinary NAG and blood pressure. The subjects were divided into 7 subgroups, according to their age (< 30, 30-39, 40-49, 50-59, 60-69, 70-79, 80 or more years). There was a positive correlation between NAG index and age (r = 0.36; P < 0.001). The regression equation relating NAG index (y) to age (x) was y = 0.065x + 0.97. The mean NAG indexes for the 7 subgroups divided by age were significantly different (P < 0.01). There was a positive correlation between NAG index and systolic blood pressure (r = 0.18; P < 0.05), but was not between diastolic blood pressure and NAG index. In multiple regression analysis, age and BUN significantly correlated with NAG index (r = 0.32; P < 0.01, r = 3.3; P = 0.07, respectively), although there was no correlation between systolic blood pressure and NAG index. This cross-sectional study showed a clear elevation in NAG index with age. The rate of elevation was 0.65 per decade. Urinary excretion of NAG may be unrelated to blood pressure. (+info)A quantitative study of pinocytosis and lysosome function in experimentally induced lysosomal storage. (8/982)
The highly pinocytic epithelial cells of the visceral yolk sac from 17.5-day rat conceptuses were used as a model in which to induce engorgement of the vacuolar system by direct accumulation of substances that are not hydrolysed by lysosomal enzymes. The ultra-structural appearances of these cells in pregnant animals that 24-48h before had received intraperitoneal injections of Triton WR-1339, polyvinylpyrrolidone, dextran or sucrose revealed gross abnormalities that were confined to the vacuolar system; in comparison with normal tissue the number, and in some cases the size, of vacuoles was increased, leading to close packing within the apical cytoplasm and distortion of the normal rounded shape. By culturing yolk sacs in vitro, rates of ingestion of 125I-labelled polyvinylpyrrolidone and of 125I-labelled bovine serum albumin were determined, together with the rate of digestion of the labelled protein. The rates of exocytosis of 125I-labelled polyvinylpyrrolidone and of lysosomal enzymes were also determined. No significant differences between normal and highly vacuolated tissues were found. Apparently marked vacuolation of these cells by these agents is without significant effect on pinocytosis, exocytosis or intralysosomal proteolysis. (+info)
Corynebacterium glutamicum possesses β-N-acetylglucosaminidase | BMC Microbiology | Full Text
NAG elisa kit | Canine N-Acetyl-beta-D-Glucosaminidase ELISA Kit-AAS02154.1
EndoS2 is a unique and conserved enzyme of serotype M49 group A Strept by Jonathan Sjogren, Weston B. Struwe et al.
Andrea Cosimo DAmico | Fondazione Santa Lucia
The effect of short-term low-dose cyclosporin on renal function and blood pressure in patients with psoriasis - UEA Digital...
Association between nonalbumin proteinuria and renal tubular damage of N-acetyl-β-D-glucosaminidase and its clinical relevance...
Endo-β-N-Acetylglucosaminidase catalysed glycosylation: tolerance of enzymes to structural variation of the glycosyl amino acid...
CAZy - GH84
Alfa-N-acetilglukozaminidaza - Википедија, слободна енциклопедија
CAZy - GH35
nag anova random (g04bbc) : NAG Library, Mark 25
g02hm:: Correlation and Regression Analysis (NAG Toolbox)
Mucopolysaccharidosis type IIIB may predominantly present with an attenuated clinical phenotype.
Mucopolysaccharidosis Type Iiib: Disease Bioinformatics: Novus Biologicals
Alpha-N-Acetylglucosaminidase (N-Acetyl-Alpha-Glucosaminidase or NAG or EC 3.2.1.50) - Pipeline Review, H1 2016 | Aug 16, 2016 ...
Extension of Study HGT-SAN-055 Evaluating Administration of rhHNS in Patients With Sanfilippo Syndrome Type A (MPS IIIA) - Full...
Microbiology Society Journals | Porphyromonas gulae sp. nov., an anaerobic, gram-negative coccobacillus from the gingival...
Lysogene to Host Key Opinion Leader Meeting on Gene Therapy for Patients with Sanfilippo Syndrome Type A in New York City -...
Mucopolysaccharidosis Type IIIb (MPS3B)
Interferon gamma attenuates hypertensive renal injury in salt-sensitive Dahl rats. | Hypertension
NAGLU Antibody (monoclonal) (M02) - Mouse monoclonal antibody raised against a partial recombinant NAGLU. WB - Buy Now! |Abgent
N-acetil-β-D-glicosaminidase como biomarcador precoce de disfunção renal para a exposição ocupacional ao chumbo inorgânico<...
Pilot Newborn Screening for Sanfilippo Type A, B Launches in New York - BioNewsFeeds
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keratanase II
Summary Report | CureHunter
Pre GI: SWBIT SVG BLASTN
Research - United States
A Comparison of the Isoenzymes of N-Acetyl-β-glucosaminidase in Primate Kidney and Serum | Biochemical Society Transactions
Purification and characterization of exo-β-1,4-glucosaminidase produced by chitosan-degrading fungus, Penicillium sp. IB-37-2A ...
NIH grant for the move toward clinical trials targeting the lysosomal storage disea... ( Investigators at Nationwide Children....
β-N-Acetylhexosaminidasef | NEB
Bearing NAG4907UU manufactured by IKO can be ordered
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NAGLU gene - Genetics Home Reference
Mucopolysaccharidosis IIIB and mild skeletal anomalies: coexistence of NAGLU and CYP26B1 missense variations in the same...
University of California, Los Angeles: Dr. Elizabeth Neufeld | Cure Kirby
DMOZ - Health: Conditions and Diseases: Nutritional and Metabolic Disorders: Inherited: Sanfilippo Syndrome
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Sanfilippo Syndrome Possible Treatment
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Print - Abeona Announces Top-Line One Year Data from ABO-102 MPS IIIA Trial at ARMs Cell & Gene Meeting on the Mesa
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Molecular and Biochemical Characterization of a Novel β-N-Acetyl-D-Hexosaminidase with Broad Substrate-Spectrum from the Aisan...
John B. Sanfilippo & Son food business news, John B. Sanfilippo & Son company profile, John B. Sanfilippo & Son analysis,...
SAUPAN004467000 - AureoWiki
Dynamic Interplay between O-Linked N-Acetylglucosaminylation and Glycogen Synthase Kinase-3-dependent Phosphorylation |...
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Gene Therapy Has Potential to Treat Underlying Cause of Sanfilippo, Review Study Finds
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N ac beta glucosaminidase Dictionary Definition and More from Dictionary.net
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anti-NAGase antibody | Rabbit anti-Rat N-Acetyl Beta-D-Glucosaminidase (NAGase) Polyclonal Antibody-NP 571979.1
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Ротация логов Radius? - Программное обеспечение, биллинг и *unix системы - Форумы NAG.RU
Alpha-N-acetylglucosaminidase
α-N-acetylglucosaminidase (EC 3.2.1.50, α-acetylglucosaminidase, N-acetyl-α-D-glucosaminidase, N-acetyl-α-glucosaminidase, α-D- ... von Figura K (November 1977). "Human alpha-N-acetylglucosaminidase. 1. Purification and properties". European Journal of ... von Figura K (November 1977). "Human alpha-n-acetylglucosaminidase. 2. Activity towards natural substrates and multiple ... Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). "Mammalian alpha-acetylglucosaminidase. Enzymic properties, ...
Endo-beta-n-acetylglucosaminidase
... is a protein that in humans is encoded by the ENGASE gene. This gene encodes a cytosolic ... "Entrez Gene: Endo-beta-N-acetylglucosaminidase". Retrieved 2018-08-24. Suzuki T, Yano K, Sugimoto S, Kitajima K, Lennarz WJ, ... Butkinaree C, Cheung WD, Park S, Park K, Barber M, Hart GW (August 2008). "Characterization of beta-N-acetylglucosaminidase ... Park K, Saudek CD, Hart GW (July 2010). "Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals ...
Beta-aspartyl-N-acetylglucosaminidase
In enzymology, a beta-aspartyl-N-acetylglucosaminidase (EC 3.2.2.11) is an enzyme that catalyzes the chemical reaction 1-beta- ... Eylar EH, Murakami M (1966). "beta-Aspartyl-N-acetylglucosaminidase from epididymis". Methods Enzymol. Methods in Enzymology. 8 ...
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
The enzyme N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (EC 3.1.4.45) catalyzes the reaction glycoprotein N- ... Other names in common use include α-N-acetylglucosaminyl phosphodiesterase, lysosomal α-N-acetylglucosaminidase, phosphodiester ... glycosidase, α-N-acetyl-D-glucosamine-1-phosphodiester, N-acetylglucosaminidase, 2-acetamido-2-deoxy-α-D-glucose 1- ...
Helge Stormorken
Further evidence of a hyperactive ?-N-acetylglucosaminidase-producing allele". Clinical Genetics. 41 (5): 243-247. doi:10.1111/ ...
N-acetyl-β-d-glucosaminidase
These include: β-n-acetylglucosaminidase β-acetylaminodeoxyglucosidase β-acetamidodeoxyglucosidase β-acetylglucosaminidase n- ... Frohwein, Yaacov Zvi; Gatt, Shimon (1967-09-01). "Isolation of β-N-Acetylhexosaminidase, β-N-Acetylglucosaminidase, and β-N- ... Ueda, Mitsuhiro; Arai, Motoo (January 1992). "Purification and Some Properties ofβ-N-Acetylglucosaminidase fromAeromonassp. 10S ... IWAMOTO, Tooru; INAOKA, Megumu; NAKA, Hideyuki (1983). "Mycelial .BETA.-N-acetylglucosaminidase of Streptomyces sp. having . ...
NAGLU
N-acetylglucosaminidase, alpha is a protein that in humans is encoded by the NAGLU gene. This gene encodes an enzyme that ... "Entrez Gene: N-acetylglucosaminidase, alpha". Weber B, Blanch L, Clements PR, Scott HS, Hopwood JJ (June 1996). "Cloning and ... "Purification and partial characterization of alpha-N-acetylglucosaminidase from human liver". Journal of Biochemistry. 110 (5 ...
SGSH
... alpha-N-acetylglucosaminidase (type B; MIM 252920); acetyl CoA:alpha-glucosaminide acetyltransferase (type C; MIM 252930); and ...
Endoglycosidase H
Chien S, Weinburg R, Li S, Li Y (1977). "Endo-β-N-acetylglucosaminidase from fig latex". Biochem. Biophys. Res. Commun. 76: 317 ... doi:10.1016/0006-291x(77)90727-6. Koide N, Muramatsu T (August 1974). "Endo-beta-N-acetylglucosaminidase acting on carbohydrate ... "The release of intact oligosaccharides from specific glycoproteins by endo-beta-N-acetylglucosaminidase H". The Journal of ... "Primary structure of the Streptomyces enzyme endo-beta-N-acetylglucosaminidase H". The Journal of Biological Chemistry. 259 (12 ...
Cortical granule
N-Acetylglucosaminidase: Experimentally found within mouse cortical granules, N-Acetylglucosaminidase is a glycosidase that ... Therefore, N-Acetylglucosaminidase contributes to polyspermy prevention. p32: The name, p32, refers to the protein's molecular ...
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene. ... "Entrez Gene: NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". Lee, W. S.; Kang, C.; Drayna, D.; ... "Purification and characterization of human serum N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". Arch. ... "Purification and characterization of human lymphoblast N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". ...
Chitinase
Brunner K, Peterbauer CK, Mach RL, Lorito M, Zeilinger S, Kubicek CP (July 2003). "The Nag1 N-acetylglucosaminidase of ... Chitinases (EC 3.2.1.14, chitodextrinase, 1,4-β-poly-N-acetylglucosaminidase, poly-β-glucosaminidase, β-1,4-poly-N-acetyl ... The regulation of an endochitinase in Trichoderma atroviride is dependent on a N-acetylglucosaminidase, and the data indicates ... Family 20 includes N-acetylglucosaminidase and a similar enzyme, N-acetylhexosaminidase. And as the gene sequences of the ...
Rosalind Kornfeld
"Purification and Multimeric Structure of BovineN-Acetylglucosamine-1-phosphodiester α-N-Acetylglucosaminidase *". Journal of ... and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". J ... include defining the structure and function of N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, commonly ...
Streptomyces rochei
... produces endo-β-N-acetylglucosaminidase mithramycin, amicetin, bamicetin, and plicacetin. Kanini, ... "High-level expression of endo-β-N-acetylglucosaminidase H from Streptomyces plicatus in Pichia pastoris and its application for ...
Mucopolysaccharidosis
Sanfilippo B is caused by the missing or deficient enzyme alpha-N-acetylglucosaminidase. Sanfilippo C results from the missing ...
Paucimannosylation
Membrane-bound β-N-Acetylglucosaminidase Probably Involved in the Processing of Protein N-Glycans". Journal of Biological ... "The Drosophila fused lobes Gene Encodes an N-Acetylglucosaminidase Involved in N-Glycan Processing". Journal of Biological ... "Improvement of glycosylation structure by suppression of β-N-acetylglucosaminidases in silkworm". Journal of Bioscience and ...
Protein O-GlcNAcase
... cytosolic beta-N-acetylglucosaminidase from human brain". The Journal of Biological Chemistry. 276 (13): 9838-45. doi:10.1074/ ... cytosolic beta-N-acetylglucosaminidase from human brain". The Journal of Biological Chemistry. 276 (13): 9838-45. doi:10.1074/ ... "Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes ... further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase". The Journal of Biological ...
Beta-N-acetylgalactosaminidase
... beta-N-acetylglucosaminidase, and beta-N-acetylgalactosaminidase from calf brain". Biochemistry. 6 (9): 2775-82. doi:10.1021/ ...
PNGase F
Tachibana Y, Yamashita K, Kobata A (1982). "Substrate specificity of mammalian endo-beta-N-acetylglucosaminidase: study with ...
Glycoside hydrolase family 89
Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate. Mutations on the ... Glycoside hydrolase family 89 CAZY GH_89 includes enzymes with α-N-acetylglucosaminidase EC 3.2.1.50 activity. The enzyme ... "Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase". ... alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B ...
Hexosaminidase
Frohwein YZ, Gatt S (September 1967). "Isolation of β-N-acetylhexosaminidase, β-N-acetylglucosaminidase, and β-N- ... cytosolic beta-N-acetylglucosaminidase from human brain". J. Biol. Chem. 276 (13): 9838-45. doi:10.1074/jbc.M010420200. PMID ... beta-N-acetylglucosaminidase, hexosaminidase A, N-acetylhexosaminidase, beta-D-hexosaminidase) is an enzyme involved in the ... for β-N-acetylglucosaminidase, β-N-acetylhexosaminidase and β-N-acetylgalactosaminidase". Biochem. J. 261 (3): 1059-60. doi: ...
Lysin
Functionally, five types of lysin catalytic domain can be distinguished: Endo-β-N-acetylglucosaminidase (Endoglycosidase H, EC ... Endo-β-N-acetylglucosaminidase lysins cleave NAGs while N-acetylmuramidase lysins (lysozyme-like lysins) cleave NAMs. ...
Glycoside hydrolase family 73
... CAZY GH_73 includes peptidoglycan hydrolases with endo-β-N-acetylglucosaminidase specificity. ...
N-acetylglucosamine-6-phosphate deacetylase
"The structure of hyperthermophilic β-N-acetylglucosaminidase reveals a novel dimer architecture associated with the active site ...
Glycoside hydrolase family 85
... enzymes have endo-beta-N-acetylglucosaminidase activity EC 3.2.1.96 (CAZY GH_85). These enzymes ...
Mycoparasitism
"The Nag1 N-acetylglucosaminidase of Trichoderma atroviride is essential for chitinase induction by chitin and of major ...
Eggshell membrane
... and β-N-acetylglucosaminidase. Shell membrane is mainly used as a dietary supplement in a partially hydrolyzed powder form. " ...
Glycosylation
β-N-Acetylglucosaminidase (from Streptococcus pneumoniae): cleaves all non-reducing terminal β-linked N-acetylglucosamine ...
Penicillium oxalicum
... produces secalonic acid D, chitinase, oxalic acid, oxaline and β-N-acetylglucosaminidase and occurs ...
Carbohydrate-binding module
CBM32 modules are associated with catalytic modules such as sialidases, B-N-acetylglucosaminidases, α-N-acetylglucosaminidases ...
Browsing by Subject "Acetylglucosaminidase"
Browsing by Subject "Acetylglucosaminidase"
RCSB PDB - 1C8Y: Endo-Beta-N-Acetylglucosaminidase H, D130A Mutant
ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H. A. 265. Streptomyces plicatus. Mutation(s): 1 EC: 3.2.1.96. ... Endo-beta-N-acetylglucosaminidase H hydrolyzes the beta-(1-4)-glycosidic link of the N,N-diacetylchitobiose core of high- ... Endo-beta-N-acetylglucosaminidase H hydrolyzes the beta-(1-4)-glycosidic link of the N,N-diacetylchitobiose core of high- ... Endo-Beta-N-Acetylglucosaminidase H, D130A Mutant. *PDB DOI: 10.2210/pdb1C8Y/pdb ...
A novel bacterial β-N-acetyl glucosaminidase from Chitinolyticbacter meiyuanensis possessing transglycosylation and reverse...
Chemoenzymatic synthesis of neoglycoproteins using transglycosylation with endo-β-N-acetylglucosaminidase A<...
Chemoenzymatic synthesis of neoglycoproteins using transglycosylation with endo-β-N-acetylglucosaminidase A」の研究トピックを掘り下げます。これらが ... Chemoenzymatic synthesis of neoglycoproteins using transglycosylation with endo-β-N-acetylglucosaminidase A. / Fujita, Kiyotaka ... Chemoenzymatic synthesis of neoglycoproteins using transglycosylation with endo-β-N-acetylglucosaminidase A. Biochemical and ... Chemoenzymatic synthesis of neoglycoproteins using transglycosylation with endo-β-N-acetylglucosaminidase A. In: Biochemical ...
acetylglucosaminidase
Beta-aspartyl-N-acetylglucosaminidase - In enzymology, a beta aspartyl N acetylglucosaminidase (EC number,3.2.2.11) is an ... Alpha-N-acetylglucosaminidase - N acetylglucosaminidase, alpha (Sanfilippo disease IIIB) Identifiers Symbol NAGLU Entrez 4669 ... α-N-acetylglucosaminidase - α N ac·e·tyl·glu·co·sa·min·i·dase (as″ə təl ) (as″ə tēl″gloo kōs″ə minґĭ dās) [EC 3.2.1.50] a ... β-D-acetylglucosaminidase - β D ac·e·tyl·glu·co·sa·min·i·dase (asґə təl ) (asґə tēl″gloo kōs″ə minґĭ dās) a lysosomal ...
N-Acetyl Glucosaminidase Ctrl
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Streptococcus Lab: Id Strep Species General Methods Section 2 | CDC
A comparison of the substrate specificities of endo-β-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus...
Endo-beta-N-acetylglucosaminidases acting on the carbohydrate moieties of glycoproteins. The differential specificities of the ... A comparison of the substrate specificities of endo-β-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus ... A comparison of the substrate specificities of endo-β-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus ... A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus ...
NAGLU gene: MedlinePlus Genetics
The NAGLU gene provides instructions for producing an enzyme called alpha-N-acetylglucosaminidase. Learn about this gene and ... Alpha-N-acetylglucosaminidase removes a sugar called N-acetylglucosamine when it is at the end of the GAG chain. ... Alpha-N-acetylglucosaminidase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). GAGs ... The NAGLU gene provides instructions for producing an enzyme called alpha-N-acetylglucosaminidase. This enzyme is located in ...
CP40 from Corynebacterium pseudotuberculosis is an endo-β-N-acetylglucosaminidase | BMC Microbiology | Full Text
These endo-β-N-acetylglucosaminidases hydrolyze β-1,4-N-acetyl-D-glucosamine linkages in the chitobiose core of N-glycans in ... CP40 from Corynebacterium pseudotuberculosis is an endo-β-N-acetylglucosaminidase. *Azadeh Shadnezhad. ORCID: orcid.org/0000- ... Shadnezhad, A., Naegeli, A. & Collin, M. CP40 from Corynebacterium pseudotuberculosis is an endo-β-N-acetylglucosaminidase. BMC ... EndoS is a 108 kDa endo-β-N-acetylglucosaminidase belonging to family 18 of glycoside hydrolases (GH18) (CAZy, 2016; http://www ...
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Table - Meningitis Caused by Streptococcus suis Serotype 14, North America - Volume 15, Number 2-February 2009 - Emerging...
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Chitinase - Wikipedia
Chitinases (EC 3.2.1.14, chitodextrinase, 1,4-β-poly-N-acetylglucosaminidase, poly-β-glucosaminidase, β-1,4-poly-N-acetyl ... The regulation of an endochitinase in Trichoderma atroviride is dependent on a N-acetylglucosaminidase, and the data indicates ... Brunner K, Peterbauer CK, Mach RL, Lorito M, Zeilinger S, Kubicek CP (July 2003). "The Nag1 N-acetylglucosaminidase of ... β-1,4- N-acetylglucosaminidases (EC 3.2.1.30) split the multimer products, such as di-acetylchitobiose, chitotriose, and ...
Fact Sheet Glossary - MPS Society
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CAZy - GH20
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ExplorEnz: EC 3.1.4.45
N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase. Reaction:. glycoprotein N-acetyl-D-glucosaminyl-phospho-D- ... α-N-acetylglucosaminyl phosphodiesterase; lysosomal α-N-acetylglucosaminidase; phosphodiester glycosidase; α-N-acetyl-D- ... glucosamine-1-phosphodiester N-acetylglucosaminidase; 2-acetamido-2-deoxy-α-D-glucose 1-phosphodiester ...
Endo-beta-N-acetylglucosaminidase1
- Endo-beta-N-acetylglucosaminidase H hydrolyzes the beta-(1-4)-glycosidic link of the N,N'-diacetylchitobiose core of high-mannose and hybrid asparagine-linked oligosaccharides. (rcsb.org)
Enzyme4
- α-N-acetylglucosaminidase - An enzyme that hydrolyzes glycosides of N acetylglucosamine producing the alcohol and N acetylglucosamine. (en-academic.com)
- The NAGLU gene provides instructions for producing an enzyme called alpha-N-acetylglucosaminidase. (medlineplus.gov)
- Family 20 includes N- acetylglucosaminidase and a similar enzyme, N -acetylhexosaminidase . (wikipedia.org)
- KNE has a number of DispersinB® products in development including formulations with antibiotics and the antibiofilm enzyme β-N-Acetylglucosaminidase . (inflation.us)
Oligosaccharides1
- p-Isothiocyanatophenyl-β-D-glucopyranoside (Glc-ITC) was transferred to the reducing end of the high-mannose-type oligosaccharides using a transglycosylation activity of endo-β-N-acetylglucosaminidase A (Endo-A). A novel oligosaccharide, Man 6 GlcNAc-Glc-ITC, was synthesized as a coupling reagent for lysyl and N-terminal residues of the protein moiety. (elsevier.com)
IIIB1
- All of the mutations that cause MPS IIIB reduce or eliminate the function of alpha-N-acetylglucosaminidase. (medlineplus.gov)
Bacterial2
- Results presented here provide the first evidence for endo-β-N-acetylglucosaminidase (ENGase) involvement in bacterial resistance towards extreme concentrations of a toxic xenobiotic compound and suggest that strain RKJ100 employs ENGase as an important component in osmotic shock response for resistingextreme concentrations of ONB. (semanticscholar.org)
- Herlihey, F.A., Moynihan, P.J . and Clarke, A.J. (2014) The essential protein for bacterial flagella formation FlgJ functions as a β- N -acetylglucosaminidase. (wlu.ca)
Activity1
- The lack of alpha-N-acetylglucosaminidase activity disrupts the breakdown of a subset of GAGs called heparan sulfate. (medlineplus.gov)
Beta3
- Endo-beta-N-acetylglucosaminidases acting on the carbohydrate moieties of glycoproteins. (wikidata.org)
- Beta-N-acetilhexosaminidasa que cataliza la hidrólisis de residuos de 2-acetamido-2-desoxi-beta-glucosa terminales y no reductores de la quitobiosa y análogos mayores, así como en glicoproteínas. (bvsalud.org)
- Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. (cdc.gov)
Alpha2
- Alpha-N-acetylglucosaminidase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). (medlineplus.gov)
- Alpha-N-acetylglucosaminidase removes a sugar called N-acetylglucosamine when it is at the end of the GAG chain. (medlineplus.gov)
Products1
- β-1,4- N -acetylglucosaminidases ( EC 3.2.1.30 ) split the multimer products, such as di-acetylchitobiose, chitotriose, and chitotetraose, into monomers of N -acetylglucoseamine (GlcNAc). (wikipedia.org)
Acid-phosphatase2
Gene3
- Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha -N-acetylglucosaminidase. (nih.gov)
- Identification of 12 novel mutations in the alpha-N-acetylglucosaminidase gene in 14 patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB). (bmj.com)
- Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. (cdc.gov)
Alpha-L-iduronida1
- Disease/enzymes combinations selected for study are, in order of priority, MPS I/ alpha-L-iduronidase, MPS III B/ Alpha-N-acetylglucosaminidase, MPS VII/ beta-glucuronidase and Sandhoff disease/beta-hexosaminidase. (nih.gov)
Protein3
- At 2 ppm, injury was marked by significant increases in BALF total protein, N -acetylglucosaminidase, and lavageable ciliated cells. (nih.gov)
- Excretion of creatinine, phosphorus, protein, N-acetylglucosaminidase (NAG), and the major metabolite of DCP, N-acetyl-S-(cis-3-chloroprop-2-enyl)-cysteine (3CNAC), was measured. (nih.gov)
- iii) Treatment of the 45-kDa band with endo-ß -N-acetylglucosaminidase F reduces the apparent molecular size of both the labeled protein and the biological activity to a band of 22 kDa. (caltech.edu)
Mutations1
- All of the mutations that cause MPS IIIB reduce or eliminate the function of alpha-N-acetylglucosaminidase. (medlineplus.gov)
Extracellular2
Enzymatic1
- Phage endoly sins are already linked to five enzymatic pursuits, together with an N acetyl muramidase or true lysosyme, the lytic transglycosylases, the N acetylmuramoyl L ala nine amidases, the endo b N acetylglucosaminidases, and also the endopeptidases. (cdantigens.com)
Expression2
- Interestingly, chitinase expression in the molting fluid is delayed compared with - N -acetylglucosaminidase expression. (tutordale.com)
- Expression, purification, crystallization and preliminary crystallographic analysis of a GH20 β-N-acetylglucosaminidase from the marine bacterium Vibrio harveyi. (mpg.de)
Molecules1
- Alpha-N-acetylglucosaminidase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). (medlineplus.gov)
Strain1
- Structural basis of chitin utilization by a GH20 β-N-acetylglucosaminidase from Vibrio campbellii strain ATCC BAA-1116. (mpg.de)
Cells1
- For example, as a team, we decided to say "using moth cells to make medicine for genetic disease" instead of "optimizing the production of N-acetylglucosaminidase by Sf9 cells. (schulichleaders.com)
Molecular2
- The molecular mass of the endo-β-N-acetylglucosaminidase, named Endo-GB, was estimated to be around 63 kDa by SDS-PAGE and around 62 kDa by Hiprep S-200 chromatography, respectively. (elsevier.com)
- En esas condiciones, una ruta molecular en la que intervienen AMPK y PFKFB3 induce la glucólisis y las células paradas en mitosis muestran unos requerimientos aumentados a la glucosa, una adición que puede tener implicaciones en terapia del cáncer. (sebbm.es)
HUMAN1
- Specifically, this endo-β-N-acetylglucosaminidase S hydrolyzes the β(1-4) linkage between the two core GlcNAcs of asparagine linked biantennary complex-type glycans of human IgG Fc regions. (bulldog-bio.com)
Removes1
- Alpha-N-acetylglucosaminidase removes a sugar called N-acetylglucosamine when it is at the end of the GAG chain. (medlineplus.gov)
Domain1
- The active site domain is homologous to that of muramidase-2 of Enterococcus hirae, however, RP-HPLC analysis of muropeptides released from Bacillus subtilis peptidoglycan, after digestion with AcmA, shows that AcmA is an N-acetylglucosaminidase. (rug.nl)
Analysis1
- 9.5%) are still obscure so far, ESI-MS analysis, exoglycosidase digestions by two kinds of β-N-acetylglucosaminidase, and WGA blotting suggested that these N-glycans might bear a β1-4 linkage N-acetylglucosaminyl residue. (elsevier.com)