Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (1/1610)
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand. (+info)Gangliosides of human kidney. (2/1610)
Five gangliosides isolated from human kidney have been characterized. The two main fractions were shown to be typical extraneural gangliosides in having lactose as their neutral carbohydrate moiety. Their structures were identified as: AcNeu(alpha2-3)Gal(beta1-4)Glc(beta1-1)Cer and AcNeu(alpha2-8)AcNeu(alpha2-3)Gal(beta1-4)Glc(beta1-1)Cer. The two main hexosamine-containing gangliosides are structurally related to human blood group substances of glycosphingolipid nature. The following structures are postulated: AcNeu(alpha2-3)Gal(beta1-4)GlcNAc(beta1-3)Gal(beta1-4)Glc(beta1-1)Cer and AcNeu(alpha2-3)Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)Gal(beta1-4)Glc(beta1-1) Cer. The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1- 1)Cer. The fatty acid structure of different gangliosides was shown to resemble that of neutral glycolipids of human kidney with the nonhydroxy acids C16:0, C22:0, and C24:0 as major components. (+info)Participation of a trisaccharide-lipid in glycosylation of oviduct membrane glycoproteins. (3/1610)
Preincubation of a hen oviduct membrane preparation with UDP-Nactyl[14C]glucosamine and bacitracin, followed by incubation with GDP-mannose, leads to formation of a chloroform/methanol (2/1)-extractable glycolipid. Treatment of the lipid with mild acid results in the release of a trisaccharide shown to have the structure beta-mannosyl-N-acetylglucosamineyl-N-acetylglucosamine. Incubation of purified trisaccharide-lipid with oviduct membranes in the presence of sodium deoxycholate, Mn2+, and GDP-mannose leads to formation of a labeled glycoprotein with an apparent molecular weight of 25,000... (+info)Lectin receptor sites on rat liver cell nuclear membranes. (4/1610)
The presence and localization of lectin receptor sites on rat liver cell nuclear and other endomembranes was studied by light and electron microscopy using fluorescein and ferritin-coupled lectin conjugates. Isolated nuclei labelled with fluorescein-conjugated Concanavalin A (Con A) or wheat germ agglutinin (WGA) often showed membrane staining, which sometimes was especially bright on small stretches of the nuclear surface. Unlabelled nuclei and nuclei with a complete ring fluorescence were also seen. The nuclear fluorescence corresponded in intensity to that seen on the surface of isolated rat liver cells. Con A-ferritin particles were seldom detected on the cytoplasmic surface of the intact nuclear envelope. However, at places where the 2 leaflets of the envelope were widely separated or where the outer nuclear membrane was partly torn away, heavy labelling was seen on the cisternal surface of both the inner and outer nuclear membranes. Labelling with Con A-ferritin was also found on the cisternal side of rough endoplasmic reticulum present in the specimens. No labelling was seen on the cytoplasmic surface of mitochondrial outer membrane. The results demonstrate the presence of binding sites for Con A and WGA in nuclei and an asymmetric localization of these sites on the cisternal side of ribosome-carrying endomembranes in rat liver cells. (+info)Role of surface proteins in Vibrio cholerae attachment to chitin. (5/1610)
The role of surface proteins in Vibrio cholerae attachment to chitin particles in vitro was studied. Treatment of V. cholerae O1 ATCC 14034 and ATCC 14035 with pronase E reduced the attachment of bacteria to chitin particles by 57 to 77%. A statistically significant reduction was also observed when the attachment to chitin was evaluated in the presence of homologous Sarkosyl-insoluble membrane proteins (MPs) (67 to 84%), N-acetylglucosamine (GlcNAc) (62%), the sugar that makes up chitin, and wheat germ agglutinin (40 to 56%), a lectin that binds GlcNAc. The soluble oligomers N,N'-diacetylchitobiose or N,N', N"-triacetylchitotriose caused an inhibition of 14 to 23%. Sarkosyl-insoluble MPs able to bind chitin particles were isolated and visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis; two of these peptides (molecular sizes, 36 and 53 kDa) specifically bind GlcNAc. (+info)Platelet high affinity low density lipoprotein binding and import of lipoprotein derived phospholipids. (6/1610)
The binding of low density lipoprotein (LDL) to the platelet cell membrane could facilitate the transfer of phospholipids from LDL to the platelets. A polyclonal antibody against the platelet glycoproteins IIb/IIIa inhibited the high affinity binding of 125I-LDL by up to 80%. The transfer of pyrene (py)-labeled sphingomyelin (SM), phosphatidylcholine and phosphatidylethanolamine from LDL to the platelets was unaffected by the antibody. The lectin wheat germ agglutinin (WGA) reduced the binding of 125I-LDL to the platelets by approximately 80%. In contrast, the lectin stimulated the transfer of SM from LDL into the platelets by about three-fold. WGA also specifically augmented the transfer of py-SM between lipid vesicles and the platelets, the stimulation being abolished in the presence of N-acetylglucosamine. Dextran sulfate (DS) increased the specific binding of 125I-LDL to the platelets by up to 2.8-fold. On the other hand, the import of LDL-derived py-phospholipids was unaffected by DS. Together, the results indicate that the phospholipid transfer from LDL to the platelets is independent of the high affinity LDL binding to the platelets and is specifically stimulated by WGA. Thus, the interactions of platelets with LDL phospholipids differ markedly from those with the apoprotein components of the lipoproteins. (+info)Mutations that confer resistance to 2-deoxyglucose reduce the specific activity of hexokinase from Myxococcus xanthus. (7/1610)
The glucose analog 2-deoxyglucose (2dGlc) inhibits the growth and multicellular development of Myxococcus xanthus. Mutants of M. xanthus resistant to 2dGlc, designated hex mutants, arise at a low spontaneous frequency. Expression of the Escherichia coli glk (glucokinase) gene in M. xanthus hex mutants restores 2dGlc sensitivity, suggesting that these mutants arise upon the loss of a soluble hexokinase function that phosphorylates 2dGlc to form the toxic intermediate, 2-deoxyglucose-6-phosphate. Enzyme assays of M. xanthus extracts reveal a soluble hexokinase (ATP:D-hexose-6-phosphotransferase; EC 2.7.1.1) activity but no phosphotransferase system activities. The hex mutants have lower levels of hexokinase activities than the wild type, and the levels of hexokinase activity exhibited by the hex mutants are inversely correlated with the ability of 2dGlc to inhibit their growth and sporulation. Both 2dGlc and N-acetylglucosamine act as inhibitors of glucose turnover by the M. xanthus hexokinase in vitro, consistent with the finding that glucose and N-acetylglucosamine can antagonize the toxic effects of 2dGlc in vivo. (+info)Quantitative determination of N-acetylglucosamine residues at the non-reducing ends of peptidoglycan chains by enzymic attachment of [14C]-D-galactose. (8/1610)
The ability of human milk galactosyltransferase to attach D-galactose residues quantitatively to the C-4 of N-acetylglucosamine moieties at the ends of oligosaccharides has been utilized for the specific labeling and quantitative determination of the chain length of the glycan moiety of the bacterial cell wall. The average polysaccharide chain length of the soluble, uncrosslinked peptidoglycan secreted by Micrococcus luteus cells on incubation with penicillin G was studied with this technique and found to be approximately 70 hexosamines long. Furthermore, the peptidoglycan chain length of Escherichia coli sacculi of different cell shapes and dimensions was determined both in rod-shaped cells and in filaments induced by temperature shift of a division mutant or by addition of cephalexin or nalidixic acid. The average chain length found in most of these sacculi was between 70 and 100 hexosamines long. Small spherical 'mini' cells had chain lengths similar to those of the isogenic rod-like cells. (+info)
Expression of O-linked N-acetylglucosamine modified proteins and produ by Octavia Y. Goodwin
Dynamic Interplay between O-Linked N-Acetylglucosaminylation and Glycogen Synthase Kinase-3-dependent Phosphorylation |...
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress: A survival response of mammalian cells -...
GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels<...
Frontiers | FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells |...
Diamond Publications - Search Results
Protein O-GlcNAcylation Is Required for Fibroblast Growth Factor Signaling in Drosophila | Science Signaling
Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α...
Abstract 19733: Shear-Dependent Aortic Valve Endothelial Inflammation and Calcification Are Regulated by O-GlcNAc Modification...
Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc | Science
Human OGA binds substrates in a conserved peptide recognition groove | Biochemical Journal
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation<...
N-Acetyl-Glucosamine Binding Lectins - GlycoMatrix™
OGT O-linked N-acetylglucosamine (GlcNAc) transferase [Homo sapiens (human)] - Gene - NCBI
Profiling of Protein O-GlcNAcylation in Murine CD8<sup>+</sup> Effector- and Memory-like T...
China N-Acetyl-D-Glucosamine - China N-Acetyl-D-Glucosamine, Glucosamine
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Getting a handle on the O-GlcNAc modification - OReilly Science Art, LLC
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
3pe4 - Proteopedia, life in 3D
David Vocadlo - Department of Chemistry - Simon Fraser University
Plus it
anti-O-GlcNAc transferase antibody [GT2037] | GeneTex
N-Acetyl-D-Glucosamine (CAS No.: 7512-17-6;134451-94-8); USP - XIAN VEDA CHEMICAL CO.,LTD - ecplaza.net
Team:Northwestern/Project/Modeling - 2010.igem.org
Vegfa | High-Throughput Screen for the Chemical Inhibitors
Deciphering nucleoporin functions in nucleocytoplasmic protein transport in Drosophila.
SAUPAN002586000 - AureoWiki
N-acetyl-D-glucosamine
The Basics of Protein Structure Part 1: The Levels of Structure
O-GlcNAc (CTD110.6) | ALZFORUM
Targeted disruption the enzymes of O-GlcNAc cycling: Animal models of Disease - John Hanover
Development of Research Reagents Specific for O-Glcnac (O-Glcnac Lectenz) - Lori Yang
Kraeber & Co GmbH - N-Acetyl-D-Glucosamine
Early detection of diabetes - The Johns Hopkins University
KEGG ENZYME: 2.4.1.320
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Pomgnt2 (protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)) - Chinchilla Research Resource Database
Impact of O-GlcNAc on cardioprotection by remote ischaemic preconditioning in non-diabetic and diabetic patients. - CARDIO PEG
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism<...
Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery - Tabular View - ClinicalTrials.gov
Pomgnt1 (untagged) - Mouse protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase (Pomgnt1), transcript variant 1, ...
Enzymes of N-Acetylglucosamine Metabolism during Germ-tube Formation in Candida albicans | Microbiology Society
Analysis of nucleocytoplasmic protein shuttling by imaging flow cytometry<...
N-Acetylglucosaminyltransferase III/MGAT3 Research Products: Novus Biologicals
EGF domain-specific O-linked N-acetylglucosamine transferase
Oligomannosides or oligosaccharide-lipids as potential substrates for rat liver cytosolic α-d-mannosidase | Biochemical Journal
c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function...
nagJ - O-GlcNAcase NagJ precursor - Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 /...
Aging | The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of...
Plus it
Glucosamine
Pomgnt1 MGI Mouse Gene Detail - MGI:1915523 - protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Pomgnt2 MGI Mouse Gene Detail - MGI:2143424 - protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2
Dynamic Glycosylation in Neurons May Be Linked to Memory, Pathology | ALZFORUM
Keratan sulfate: an up-to-date review.
Histone H2B (S112) PAb - GlycoScientific
Lectin
Global (US, EU, Japan & China) N-Acetyl-D-Glucosamine (CAS 7512-17-6) Industry Supply and Consumption 2016 to 2021 Market...
Rapid myoglobin aggregation through... | ERA
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents...
RCSB PDB - 1W3B: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Journal News: JBC: Probing beneath the surface
O-GlcNAcase/OGA/MGEA5 Antibody (1C7) (H00010724-M02): Novus Biologicals
Study finds low sugar metabolite associates with disability, neurodegeneration in MS
GLC 2000 - ProgressiveHealth.com
N-Acetylglucosamine
... (GlcNAc) is an amide derivative of the monosaccharide glucose. It is a secondary amide between glucosamine ... O-GlcNAcylation is the process of adding a single N-acetylglucosamine sugar to the serine or threonine of a protein. Comparable ... Grigorian A, Araujo L, Naidu NN, Place DJ, Choudhury B, Demetriou M (2011). "N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T- ... "Inhibition of elastase enzyme release from human polymorphonuclear leukocytes by N-acetyl-galactosamine and N-acetyl-glucosamine ...
N-Acetylglucosamine receptor
The N-Acetylglucosamine receptor is a receptor which binds N-Acetylglucosamine. The N-Acetylglucosamine (GlcNAc) receptor has ... N-Acetylglucosamine+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... "Targeted gene delivery via N-acetylglucosamine receptor mediated endocytosis". Journal of Nanoscience and Nanotechnology. 14 ( ...
N-acetylglucosamine kinase
In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction ATP + N-acetyl-D- ... doi:10.1016/0076-6879(66)09085-2. Datta A (October 1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification ... Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6- ... and properties of N-acetylglucosamine kinase". Biochimica et Biophysica Acta. 220 (1): 51-60. doi:10.1016/0005-2744(70)90228-7 ...
N-acetylglucosamine deacetylase
I. N-acetylglucosamine deacetylase". The Journal of Biological Chemistry. 226 (1): 115-24. PMID 13428742. Portal: Biology v t e ... In enzymology, a N-acetylglucosamine deacetylase (EC 3.5.1.33) is an enzyme that catalyzes the chemical reaction N-acetyl-D- ...
Uridine diphosphate N-acetylglucosamine
... or UDP-GlcNAc is a nucleotide sugar and a coenzyme in metabolism. It is used by ... UDP-GlcNAc is extensively involved in intracellular signaling as a substrate for O-linked N-acetylglucosamine transferases ( ... Hanover, J. A. (2001). "Glycan-dependent signaling: O-linked N-acetylglucosamine". The FASEB Journal. 15 (11): 1865-1876. ... glycosyltransferases to transfer N-acetylglucosamine residues to substrates. D-Glucosamine is made naturally in the form of ...
UDP-N-acetylglucosamine diphosphorylase
Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N- ... acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate ... In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the chemical reaction UTP ... Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine ...
Peptidoglycan-N-acetylglucosamine deacetylase
N-acetylglucosamine deacetylase, peptidoglycan GlcNAc deacetylase, peptidoglycan N-acetylglucosamine deacetylase, PG N- ... Peptidoglycan-N-acetylglucosamine+deacetylase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Peptidoglycan-N-acetylglucosamine deacetylase (EC 3.5.1.104, HP310, PgdA, SpPgdA, BC1960, peptidoglycan deacetylase, ... "Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis". The ...
UDP-N-acetylglucosamine kinase
... (EC 2.7.1.176, UNAG kinase, zeta toxin, toxin PezT, ATP:UDP-N-acetyl-D-glucosamine 3'- ... UDP-N-acetylglucosamine+kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 2.7.1 ... UDP-N-acetylglucosamine 1-carboxyvinyltransferase. These enzymes are found as part of plasmid-encoded and chromosomal bacterial ...
N-acetylglucosamine-6-sulfatase
N-acetylglucosamine 6-sulfate sulfatase, O,N-disulfate O-sulfohydrolase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, ... N-acetylglucosamine-6-sulfatase (EC 3.1.6.14, glucosamine (N-acetyl)-6-sulfatase, systematic name N-acetyl-D-glucosamine-6- ... N-acetylglucosamine-6-sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH) This article ... Kresse H, Fuchs W, Glössl J, Holtfrerich D, Gilberg W (December 1981). "N-acetylglucosamine-6-sulfate by human β-N- ...
UDP-N-acetylglucosamine 4-epimerase
... uridine diphosphate N-acetylglucosamine-4-epimerase, and uridine 5'-diphospho-N-acetylglucosamine-4-epimerase. This enzyme ... In enzymology, an UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) is an enzyme that catalyzes the chemical reaction UDP-N- ... Other names in common use include UDP acetylglucosamine epimerase, uridine diphosphoacetylglucosamine epimerase, ...
UDP-N-acetylglucosamine 2-epimerase
... uridine diphospho-N-acetylglucosamine 2'-epimerase, and uridine diphosphate-N-acetylglucosamine-2'-epimerase. This enzyme ... The UDP-N-acetylglucosamine 2-epimerase from rat liver displays both epimerase and kinase activity. As of late 2007, 4 ... In enzymology, an UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) is an enzyme that catalyzes the chemical reaction UDP-N- ... Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem ...
N-acetylglucosamine-6-phosphate deacetylase
"N-acetylglucosamine 6-phosphate deacetylase (nagA) is required for N-acetyl glucosamine assimilation in Gluconacetobacter ... "An alternative route for recycling of N-acetylglucosamine from peptidoglycan involves the N-acetylglucosamine ... "Purification and characterization of N-acetylglucosamine 6-phosphate deacetylase with activity against N-acetylglucosamine from ... N-acetylglucosamine (GlcNAc) enters the cell as part of the breakdown of the cell wall. GlcNAc, a monosaccharide and derivative ...
N-acetylglucosamine-1-phosphate transferase
... is a transferase enzyme. It is made up of two alpha (α), two betas (β), and two ... GeneReviews/NIH/NCBI/UW entry on Mucolipidosis II GeneReviews/NIH/NCBI/UW entry on Mucolipidosis III Gamma N-acetylglucosamine- ...
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
... pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvate-uridine ... UDP-N-acetylglucosamine enoylpyruvyltransferase, enoylpyruvate transferase, phosphoenolpyruvate-UDP-acetylglucosamine-3- ... In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme that catalyzes the first ... ISBN 0-07-144578-1. Other names in common use include MurA transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, ...
UDP-N-acetylglucosamine 6-dehydrogenase
In enzymology, an UDP-N-acetylglucosamine 6-dehydrogenase (EC 1.1.1.136) is an enzyme that catalyzes the chemical reaction UDP- ... Other names in common use include uridine diphosphoacetylglucosamine dehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2- ...
UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
... (EC 3.2.1.183, UDP-N-acetylglucosamine 2-epimerase, GNE (gene), siaA (gene), ... UDP-N-acetylglucosamine+2-epimerase+(hydrolysing) at the US National Library of Medicine Medical Subject Headings (MeSH) Portal ... Blume A, Ghaderi D, Liebich V, Hinderlich S, Donner P, Reutter W, Lucka L (June 2004). "UDP-N-acetylglucosamine 2-epimerase/N- ... Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". The Journal of ...
UDP-3-O-N-acetylglucosamine deacetylase
In molecular biology, UDP-3-O-N-acetylglucosamine deacetylase (also known as UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine ... The structure of UDP-3-O-N-acetylglucosamine deacetylase (LpxC) from Aquifex aeolicus has a two-layer alpha/beta structure ...
UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
... (EC 2.7.8.33, UDP-N-acetylglucosamine: ... UDP-N-acetylglucosamine---undecaprenyl-phosphate+N-acetylglucosaminephosphotransferase at the US National Library of Medicine ...
UDP-3-O-acyl-N-acetylglucosamine deacetylase
N-acetylglucosamine deacetylase) is an enzyme with systematic name UDP-3-O-((3R)-3-hydroxymyristoyl)-N-acetylglucosamine ... N-acetylglucosamine deacetylase, UDP-(3-O-acyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-N- ... UDP-3-O-acyl-N-acetylglucosamine deacetylase (EC 3.5.1.108, LpxC protein, LpxC enzyme, LpxC deacetylase, deacetylase LpxC, UDP- ... UDP-3-O-acyl-N-acetylglucosamine+deacetylase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: ...
UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase
In enzymology, an UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase (EC 2.7.8.18) is an enzyme that catalyzes ... "Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine". FEBS Lett. 151 (1): 15-8. doi: ...
UDP-N-acetylglucosamine-decaprenyl-phosphate N-acetylglucosaminephosphotransferase
UDP-N-acetylglucosamine---decaprenyl-phosphate+N-acetylglucosaminephosphotransferase at the US National Library of Medicine ... UDP-N-acetylglucosamine---decaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.35, GlcNAc-1-phosphate ...
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase, and UDP-acetylglucosamine-dolichol phosphate ... Other names in common use include UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase, UDP-GlcNAc:dolichyl- ... Villemez CL, Carlo PL (1980). "Properties of a soluble polyprenyl phosphate UDP-D-N-acetylglucosamine N-acetylglucosamine-1- ... In enzymology, an UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) is an enzyme ...
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase, and UDP-N-acetylglucosamine:glycoprotein N- ... lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase, UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1 ... Other names in common use include UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase, UDP-GlcNAc ... Waheed A, Hasilik A, von Figura K (1982). "UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1- ...
UDP-xylose and UDP-N-acetylglucosamine transporter
... is a protein that in humans is encoded by the SLC35B4 gene. Solute carrier ... gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine". ...
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
The enzyme N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (EC 3.1.4.45) catalyzes the reaction glycoprotein N- ...
Uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase
... may refer to: Protein O-GlcNAc ...
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
... (EC 4.2.1.135, PglF) is an enzyme with systematic name UDP-N- ... UDP-N-acetylglucosamine+4,6-dehydratase+(configuration-retaining) at the US National Library of Medicine Medical Subject ...
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
... (EC 4.2.1.115, FlaA1, UDP-N-acetylglucosamine 5-inverting 4,6 ... UDP-N-acetylglucosamine+4,6-dehydratase+(configuration-inverting) at the US National Library of Medicine Medical Subject ... PseB, UDP-N-acetylglucosamine hydro-lyase (inverting, UDP-2-acetamido-2,6-dideoxy-β-L)arabino-hex-4-ulose-forming)) is an ... synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction". Glycobiology. 16 (9): 8C-14C. doi:10.1093/glycob/cwl010 ...
Acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase
In enzymology, an acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) is an enzyme that ... The systematic name of this enzyme class is (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3- ... Other names in common use include UDP-N-acetylglucosamine acyltransferase and uridine diphosphoacetylglucosamine ... N-acetylglucosamine Thus, the two substrates of this enzyme are (R)-3-hydroxytetradecanoyl-acyl-carrier-protein and UDP-N- ...
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine...
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine: ... N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine: ... octacis-undecaprenyl-N-acetylglucosamine + 2 tRNA This Staphylococcus aureus enzyme catalyses the successive transfer of two ... octacis-undecaprenyl-N-acetylglucosamine + 2 glycyl-tRNA ⇌ {\displaystyle \rightleftharpoons } N-acetylmuramoyl-L-alanyl-D- ...
Side Effects of N-Acetylglucosamine | livestrong
N-acetylglucosamine supplements are generally considered safe. Minor side effects occur uncommonly and serious side effects are ... Side Effects of N-Acetylglucosamine By Tina M. St. John, MD Updated April 29, 2018 ... N-acetylglucosamine (NAG) is an amino sugar, a derivative of the simple sugar glucose. Your body produces NAG, which serves as ... Experimental and Therapeutic Medicine: Effect of N-Acetylglucosamine Administration on Cartilage Metabolism and Safety in ...
Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins
Incorporation of N-acetylglucosamine-specific agglutinins from wheat germ (Triticum aestivum; WGA), thorn apple (Datura ... Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins Br J Nutr. 1993 Jul;70(1):313-21. ... Incorporation of N-acetylglucosamine-specific agglutinins from wheat germ (Triticum aestivum; WGA), thorn apple (Datura ...
N-acetylglucosamine - Innvista
Home › Health › Nutrition › Essential Sugars › N-acetylglucosamine. N-acetylglucosamine. Note: See also Economical Alternatives ... N-acetylglucosamine is another member of the group of eight essential sugars. It is best known by its derivative, Glucosamine, ... N-acetylglucosamine concentrations were also found in mammalian brains, suggesting a role in nerve function. This would also ... The thyroid gland is known to have N-acetylglucosamine receptors on its surface which are believed to play a role in the ...
4U0W: Crystal Structure Of Yvoa From Bacillus Subtilis In Complex With N- Acetylglucosamine-6-phosphate
Molecules | Free Full-Text | Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors...
UDP: uridine diphosphate; GlcNAc: N-Acetylglucosamine; UDP-GlcNAc: uridine diphosphate N-acetylglucosamine; DMSO: dimethyl ... "Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not ... "Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not ... Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not ...
Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases<...
Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases. Charles R Sweet, Andrew Preston, Elinor ... Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases. / Sweet, Charles R; Preston, Andrew; ... Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases. In: Journal of Biological Chemistry. ... These acyl chains are attached by UDP-N-acetylglucosamine acyltransferase (LpxA). To determine the origin of the acyl ...
An acidic, thermostable exochitinase with β-N-acetylglucosaminidase activity from Paenibacillus barengoltzii converting chitin...
Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing one N-acetylglucosamine in the core<...
Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing one N-acetylglucosamine in the core. ... Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing one N-acetylglucosamine in the core. In ... Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing one N-acetylglucosamine in the core. / ... Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing one N-acetylglucosamine in the core. ...
Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis | BMC Immunology |...
The sulfation of these ligands depends on the action of two HEV-expressed N-acetylglucosamine 6-O-sulfotransferases: GlcNAc6ST- ... Yang, J., Rosen, S.D., Bendele, P. et al. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse ... Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. *Jiwei Yang1,4, ... The sulfation of these ligands depends on the action of two HEV-expressed N-acetylglucosamine 6-O-sulfotransferases: GlcNAc6ST- ...
N Acetyl Glucosamine - UPC Food Search
N Acetyl Glucosamine. What is N-Acetyl-Glucosamine?. N-Acetyl-Glucosamine (NAG) is a monosaccharide derivative of glucose. It ... Products containing N Acetyl Glucosamine. The percentage represents the approximate total number of food products from UPC Food ... Searchs data that contain the ingredient, "N Acetyl Glucosamine".. The data is calculated from UPC Food Searchs product data ...
N-Acetyl Glucosamine (NAG) - Humblebee & Me
N-Acetyl Glucosamine (NAG) is a compound that is found in our skin. In skin care products it improves barrier function, boosts ... I like to save N-Acetyl Glucosamine (NAG) for facial products, where it can work its magic and be appreciated. NAG does so many ... Otherwise you could replace N-Acetyl Glucosamine (NAG) with a humectant, like glycerine or sodium lactate, or just use more ... Stored somewhere cool, dark, and dry, N-Acetyl Glucosamine (NAG) should last two years.. ...
N. Acetylglucosamine pack of 60 capsules - Epigenetics
Acetylglucosamine pack of 60 capsules are a pure food supplement, manufactured in a high quality production facility in the UK. ... N. Acetylglucosamine pack of 60 capsules. £15.94. Sorry we cant ship this product to you while youre location is set to Error ... Be the first to review "N. Acetylglucosamine pack of 60 capsules" Cancel reply. You must be logged in to post a review. ... N. Acetylglucosamine is an amino sugar (the building blocks of mucopolysaccharides. It is formed from L-glutamine and glucose ...
IMSEAR at SEARO: Turnover of inducible N-acetylglucosamine catabolic enzymes in Candida albicans.
Organika NAG (N-ACETYL GLUCOSAMINE) 500 mg 60 Capsules
N-Acetyl Glucosamine (NAG) by Allergy Research Group 90ct
JoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
Frank, K.L.; Patel, R. Poly-N-acetylglucosamine is not a major component of the extracellular matrix in biofilms formed by ... Reduction of S. aureus poly-β-(1,6)-N-acetylglucosamine. [151]. Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter ... Also, the abundance of S. aureus poly-β-(1,6)-N-acetylglucosamine was also cut with anidulafungin. ...
Studies on hog spleen N-acetylglucosamine kinase : II. Allosteric regulation of the activity of N-acetylglucosamine kinase -...
Studies on hog spleen N-acetylglucosamine kinase : II. Allosteric regulation of the activity of N-acetylglucosamine kinase ... Kinetic studies of hog spleen N-acetylglucosamine kinase indicate that N-acetylglucosamine-6-phosphate (GlcNAc-6-p), the ... All of these results strongly suggest that the hog spleen N-acetylglucosamine kinase is a regulatory enzyme, and the end ... Datta, Asis (1971) Studies on hog spleen N-acetylglucosamine kinase : II. Allosteric regulation of the activity of N- ...
PGM3 gene: MedlinePlus Genetics
OGT / O-Linked N-Acetylglucosamine Transferase抗体(ab96718)| Abcam中文官网
O-Linked N-Acetylglucosamine Transferase抗体经WB,IP验证,可与人,小鼠,大鼠样本反 ... O-Linked N-Acetylglucosamine Transferase兔多克隆抗体(ab96718),OGT / ... O linked N acetylglucosamine (GlcNAc) transferase antibody. *O linked N acetylglucosamine transferase 110 kDa subunit antibody ... UDP N acetylglucosamine peptide N acetylglucosaminyltransferase 110 kDa subunit antibody. *UDP N acetylglucosamine peptide
Anti-aging: Why You Should Look Out For Acetyl Glucosamine. - The Dermatology Review
Acetyl glucosamine, or N-acetyl glucosamine, is a monosaccharide derivative of glucose, yes the sugar. Acetyl glucosamine has ... How Does Acetyl Glucosamine Benefit The Skin?. Acetyl glucosamine functions as an anti-aging skin care ingredient based on its ... Is Acetyl Glucosamine Safe?. There is limited data available on the safety of acetyl glucosamine as used in cosmetics and ... What Is Acetyl Glucosamine?. Acetyl glucosamine is a skin-replenishing ingredient that helps to reduce signs of aging. ...
Table 2 - Environmental Source of Candida dubliniensis - Volume 13, Number 5-May 2007 - Emerging Infectious Diseases journal -...
Interaction of Neisseria meningitidis group X N-acetylglucosamine-1-phosphotransferase with its donor substrate
... which transfers N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to the 4-hydroxyl of the N-acetylglucosamine on ... The capsular polysaccharide of Group X is a homopolymer of N-acetylglucosamine α(1-4) phosphate and is a vaccine target for ... Interaction of Neisseria meningitidis group X N-acetylglucosamine-1-phosphotransferase with its donor substrate. dc.rights. ... Moreover, our survey of analogs with modifications on the N-acetylglucosamine residue of the sugar nucleotide donor highlights ...
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Homoserine kinase - Wikipedia
Thus, the two substrates of this enzyme are ATP and L-homoserine, whereas its two products are ADP and O-phospho-L-homoserine. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-homoserine O-phosphotransferase. Other names in common use include homoserine kinase (phosphorylating), and HSK. This enzyme participates in glycine, serine and threonine metabolism. ...
Antibiotic Resistance in Dermatology: Mechanisms of Resistance
Glycobiology and Extracellular Matrices
O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. ... O-GlcNAcylation is the covalent addition of an O-linked β-N-acetylglucosamine (O-GlcNAc) sugar moiety to hydroxyl groups of ... The role of O-linked N-acetylglucosamine (O-GlcNAc) modification in the cell cycle has been enigmatic. Previously, both O- ... Here, we identified O-linked β-N-acetylglucosamine (O-GlcNAc)-transferase (OGT) as one of Chk1s substrates. We found that Chk1 ...
An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP- N-acetylglucosamine transferase | CDG Hub
Publications / An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP- N-acetylglucosamine transferase ... An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP- N-acetylglucosamine transferase. ... biosynthesis is catalyzed by the conserved ALG13/ALG14 heterodimeric UDP-N-acetylglucosamine transferase (GnTase). In humans, ...
TransferaseUridine Diphosphate N-AcetylglucosamineGlcNAcKinaseEnzymeMoleculeAmino sugarGlucosamineSugarsPolymerTurnoverPolysaccharideIngredientsFormSugarCommonTransferaseSingle N-acetylglucosamineModified with O-linked N-acetylglucosamineENZYMEDeacetylaseChitinMannoseProteinsSubunitsMetabolicModificationProteinGlycoproteinsReceptorsCatalyzesSynthesisStructuralTransferAlphaGrowthCellDomainDataFamilyCurrentStudyDevelopmentAbilityProduction
Transferase3
- Recombinant fragment corresponding to Human OGT/ O-Linked N-Acetylglucosamine Transferase aa 213-462. (abcam.cn)
- The second step of eukaryotic lipid-linked oligosaccharide (LLO) biosynthesis is catalyzed by the conserved ALG13/ALG14 heterodimeric UDP-N-acetylglucosamine transferase (GnTase). (cdghub.com)
- Mutations in N -acetylglucosamine ( O -GlcNAc) transferase in patients with X-linked intellectual disability. (bvsalud.org)
Uridine Diphosphate N-Acetylglucosamine1
- This conversion is required to make a sugar called uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), which is needed to transfer sugars to growing oligosaccharides during glycosylation. (medlineplus.gov)
GlcNAc6
- Kinetic studies of hog spleen N-acetylglucosamine kinase indicate that N-acetylglucosamine-6-phosphate (GlcNAc-6-p), the product of the reaction and UDP-N-acetylglycosamine (UDP-GlcNAc), the end product of the pathway of N-acetylglucosamine (GlcNAc) metabolism, are noncompetitive inhibitors. (ias.ac.in)
- All of these results strongly suggest that the hog spleen N-acetylglucosamine kinase is a regulatory enzyme, and the end product UDP-GlcNAc and the reaction product GlcNac-6-p both act on the enzyme as feedback inhibitor. (ias.ac.in)
- Chaney, W & Stanley, P 1985, ' A lectin-resistant glycosylation mutant with partially inactive UDP-N-acetylglucosamine: α1,3 mannoside β1,2 N-acetylglucosaminyltransferase I(GlcNAc-TI) ', Federation Proceedings , vol. 44, no. 5, pp. (elsevier.com)
- In E. coli , AmpG is specific for the import of N -acetylglucosamine (GlcNAc)-anhydroMurNAc(−peptides) which are common PGN turnover products, with the disaccharide portion as a minimal requirement. (biomedcentral.com)
- Gnt-VB is predominantly expressed in brain and catalyses the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. (embl.de)
- The 45-kDa form was pulled down by lectin concanavalin A (Con A) and Galant husnivalis lectin (GNL), indicating an immature glycan with a high amount of mannose (Man), whereas the 65-kDa form is a mature glycan composed of acetylglucosamine (GlcNAc) and poly-N-acetyllactosame (poly-LacNAc) that was pulled down by wheat germ agglutinin (WGA) and tomato lectin, respectively. (emory.edu)
Kinase1
- Studies on hog spleen N-acetylglucosamine kinase : II. (ias.ac.in)
Enzyme3
- The PGM3 enzyme converts a molecule called N-acetylglucosamine-6-phosphate into a different molecule called N-acetylglucosamine-1-phosphate. (medlineplus.gov)
- This enzyme catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. (embl.de)
- 1994. N-acetylglucosamine dynamics in freshwater environment: concentration of amino-sugars, extracellular enzyme activities, and microbial uptake . (jcu.cz)
Molecule2
- The structural difference is this: N-acetylglucosamine has a portion of an acetic acid molecule attached to it, causing the body to handle the two compounds differently. (innvista.com)
- Chitin is a molecule made up of bound units of acetylglucosamine, which is joined in such a way as to allow for increased points at which hydrogen bonding can occur. (cdc.gov)
Amino sugar2
- N-acetylglucosamine (NAG) is an amino sugar, a derivative of the simple sugar glucose. (livestrong.com)
- N. Acetylglucosamine is an amino sugar (the building blocks of mucopolysaccharides. (epigenetics-international.com)
Glucosamine2
- There are three common commercial forms of Glucosamine: N-acetylglucosamine, hydrochloride, and sulfate. (innvista.com)
- In fact, N-acetylglucosamine and Glucosamine sulfate are two entirely different molecules. (innvista.com)
Sugars1
- N-acetylglucosamine is another member of the group of eight essential sugars. (innvista.com)
Polymer2
- We have demonstrated previously that the formation of the polymer is catalyzed by a phosphotransferase which transfers N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to the 4-hydroxyl of the N-acetylglucosamine on the nonreducing end of the growing chain. (rpi.edu)
- The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. (unl.edu)
Turnover2
Polysaccharide2
- The capsular polysaccharide of Group X is a homopolymer of N-acetylglucosamine α(1-4) phosphate and is a vaccine target for prevention of disease associated with this meningococcal serogroup. (rpi.edu)
- A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. (semanticscholar.org)
Ingredients1
- We respect nature and as such we do our part and only use vegan-friendly ingredients in our N. Acetylglucosamine. (epigenetics-international.com)
Form1
- Scientific literature does not support the use of N-acetylglucosamine or the hydrochloride form. (innvista.com)
Sugar2
- Moreover, our survey of analogs with modifications on the N-acetylglucosamine residue of the sugar nucleotide donor highlights the importance of substituents at C2 and C4 of the sugar residue. (rpi.edu)
- The receptor sugar for WGA is N -acetylglucosamine, with preferential binding to dimers and trimers of this sugar. (vectorlabs.com)
Common1
- WGA can bind oligosaccharides containing terminal N -acetylglucosamine or chitobiose, structures which are common to many serum and membrane glycoproteins. (vectorlabs.com)
Transferase11
- O-linked β-N-acetylglucosamine (O-GlcNAc) modification of epidermal growth factor (EGF) domains catalyzed by EGF domain O-GlcNAc transferase (EOGT) is the first example of GlcNAc modification in the lumen of the endoplasmic reticulum (ER). (nih.gov)
- Nutrient levels dictate the activity of O-linked N-acetylglucosamine transferase (OGT) to regulate O-GlcNAcylation, a post-translational modification mechanism to "fine-tune" intracellular signaling and metabolic status. (umn.edu)
- This technology includes the development and use of small molecules that inhibit O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase (OGT) for a variety of pathologies, including Alzheimer's disease, cancer, cancer, diabetes, and neurodegenerative disorders the treatment of cancer and as a potential antiviral. (nih.gov)
- Further work with O-linked beta-N-acetylglucosamine transferase (OGT) inhibitors will permit the further study of the biological role of OGT in cell homeostasis. (nih.gov)
- The series of O-linked beta-N-acetylglucosamine transferase (OGT) inhibitors described in this technology exhibit improved binding properties and OGT inhibition. (nih.gov)
- Part of UDP-N-acetylglucosamine transferase complex. (nih.gov)
- Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T. Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome. (nih.gov)
- Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT). (mpg.de)
- UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc- transferase. (expasy.org)
- A suite of tools that enable small molecular regulation (Trimethoprim/Shield) of the expression of the O-GlcNAc transferase (OGT), O-GlcNAcase (OGT), Glutamine Fructose-6phophate aminotransferase 1, 2 (GFAT1,2), and UDP-N-Acetylglucosamine Pyrophosphorylase (UAP1/2). (nih.gov)
- Marquardt, J. L., E. D. Brown, C. T. Walsh, and K. S. Anderson, Isolation and Structural Elucidation of a Tetrahedral Intermediate in the UDP-N-acetylglucosamine Enolpyruvoyl Transferase Enzymatic Pathway, Journal of the American Chemical Society, Vol. 115, 1993, p. 10398-9. (nih.gov)
Single N-acetylglucosamine2
- The chemical structures of the O-glycosylations were determined to be single N-acetylglucosamine residues. (nih.gov)
- In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. (doabooks.org)
Modified with O-linked N-acetylglucosamine1
- 1996. The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine. (cosmobio.co.jp)
ENZYME2
- Patients with type D lack the enzyme N- acetylglucosamine-6-sulfatase. (medscape.com)
- Phosphoacetylglucosamine mutase (PAGM) is a human enzyme that is the key to the formation of the essential metabolite UDP-N-acetylglucosamine. (umsystem.edu)
Deacetylase1
- Quaternary variations in the structural assembly of N-acetylglucosamine-6-phosphate deacetylase from Pasteurella multocida. (ncbs.res.in)
Chitin3
- N-Acetylglucosamine is the basic unit of the biopolymer chitin, which forms the outer coverings of insects and crustaceans (shrimp, crab, etc. (greenmedinfo.com)
- Chitin is a molecule made up of bound units of acetylglucosamine, which is joined in such a way as to allow for increased points at which hydrogen bonding can occur. (cdc.gov)
- Investigation of the successional dynamics of a soil microbiome during 21-weeks of enrichment on chitin and its monomer, N-acetylglucosamine (NAG). (pnnl.gov)
Mannose2
- Following transfer of mannose (Man) to Ser or Thr by protein O-mannosyltransferase (POMT), either POMT1 or POMT2, the O-Man can be further modified with N -acetylglucosamine, galactose, sialic acid, PO 4 , N -acetylgalactosamine, glucuronic acid, and xylose to generate structures, such as those illustrated in Fig. 1 . (pnas.org)
- Binding properties of the N-acetylglucosamine and high-mannose N-glycan PP2-A1 phloem lectin in Arabidopsis. (archives-ouvertes.fr)
Proteins1
- The EOGT gene provides instructions for making a protein that modifies certain other proteins by transferring a molecule called N-acetylglucosamine to them. (nih.gov)
Subunits1
- Earlier studies had linked mutations in a gene called Gnptab (for N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) to stuttering in some people. (nih.gov)
Metabolic2
- Predicted to act upstream of or within UDP-N-acetylglucosamine metabolic process and protein glycosylation. (mcw.edu)
- Hypertrophied hearts accumulated lactate, pyruvate and glycogen, and displayed increased protein O-linked N-acetylglucosamine, which was prevented by increasing availability of non-glucose substrates in vivo by a ketogenic diet (KD) or a high-fat diet, which reversed the structural, metabolic and functional remodelling of non-stressed cMPC1-/- hearts. (internalmedicineiowa.org)
Modification1
- Modification of RelA by O-linked N-Acetylglucosamine links glucose metabolism to NF-B acetylation and transcription. (mskcc.org)
Protein2
- α1,4-linked N-acetylglucosamine (αGlcNAc), a unique O-glycan specific to gastric gland mucus, is biosynthesized by α1,4-N-acetylglucosaminyltransferase (α4GnT) and primarily bound at the terminal glycosylated residue to scaffold protein MUC6. (elsevier.com)
- Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine. (doktori.hu)
Glycoproteins1
- 10. Mild alkaline borohydride treatment liberates N-acetylglucosamine linked oligosaccharide chains of glycoproteins. (nih.gov)
Receptors1
- Cell surface receptors that bind to ACETYLGLUCOSAMINE . (bvsalud.org)
Catalyzes1
- Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. (uniprot.org)
Synthesis1
- Alternatively POMGnT2 can add N -acetylglucosamine in β1,4-linkage ( Near Left ) leading to the synthesis of a complex structure that is still under investigation. (pnas.org)
Structural1
- The production of cartilage, tendons, and joints depend on the structural integrity of N-Acetylglucosamine. (greenmedinfo.com)
Transfer1
- Research suggests that the EOGT gene mutations reduce or eliminate the protein's ability to transfer N-acetylglucosamine. (nih.gov)
Alpha3
- Acetylglucosamine is being promoted in skin care products as a new AHA (Alpha Hydroxy Acid) alternative. (valuemarketresearch.com)
- Bovine colostrum UDP-N- acetylglucosamine: .alpha. (genome.jp)
- D-mannoside .beta.2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine: .alpha. (genome.jp)
Growth2
- Acetylglucosamine is widely used to treat various disorders due to its health-promoting features, which will boost its market growth. (valuemarketresearch.com)
- The growth and trends of Acetylglucosamine Industry provide a holistic approach to this study. (valuemarketresearch.com)
Cell1
- Fungi have cell walls composed of a polymer of N-Acetylglucosamine. (greenmedinfo.com)
Domain1
- Energy landscape of the domain movement in Staphylococcus aureus UDP-N-acetylglucosamine 2-epimerase. (nih.gov)
Data1
- This section of the acetylglucosamine market report provides detailed data on the segments by analyzing them at country and regional level, thereby assisting the strategist in identifying the target demographics for the respective product or services with the upcoming opportunities. (valuemarketresearch.com)
Family1
- We assess the model on the UDP-N-acetylglucosamine acyltransferase (LPXA) family, as in our previous report, and we extend this study to all other members of the left-handed parallel beta helix fold (LβH) superfamily whose structure has been determined. (biomedcentral.com)
Current1
- This section covers the regional outlook, which accentuates current and future demand for the Acetylglucosamine market across North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. (valuemarketresearch.com)
Study1
- The global demand for Acetylglucosamine Market is presumed to reach the market size of nearly USD XX MN by 2027 from USD XX MN in 2020 with a CAGR of XX% under the study period of 2021 - 2027. (valuemarketresearch.com)
Development1
- Acetylglucosamine has also been related to skin advantages such as wrinkle reduction, hydration, and decreasing the development of the skin pigment melanin. (valuemarketresearch.com)
Ability1
- N-acetylglucosamine is being studied for its ability to brighten the skin's complexion and its anti-aging characteristics, which may help reduce age spots caused by cumulative skin damage caused by excessive UV (ultraviolet) radiation over time. (valuemarketresearch.com)
Production2
- A non-sticky lightweight formula containing Niacinamide 10% and N-acetylglucosamine 2% to balance oil production, minimize the appearance of enlarged pores, calm acne prone skin and effectively target hyperpigmentation and post acne marks. (theformularx.com)
- 4. Choi AH, Slamti L, Avci FY, Pier GB, Maira-Litrán T. The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-β-1-6-N-acetylglucosamine, which is critical for biofilm formation. (southernbiotech.com)