Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.
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Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
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Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
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Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding. (1/3)

Antibody 26-10, obtained in a secondary immune response, binds digoxin with high affinity (K(a) = 1.3 x 10(10) M(-1)) because of extensive shape complementarity. We demonstrated previously that mutations of the hapten contact residue HTrp-100 to Arg (where H refers to the heavy chain) resulted in increased specificity for digoxin analogs substituted at the cardenolide 16 position. However, mutagenesis of H:CDR1 did not result in such a specificity change despite the proximity of the H:CDR1 hapten contact residue Asn-35 to the cardenolide 16 position. Here we constructed a bacteriophage-displayed library containing randomized mutations at H chain residues 30-35 in a 26-10 mutant containing Arg-100 (26-10-RRALD). Phage were selected by panning against digoxin, gitoxin (16-OH), and 16-acetylgitoxin coupled to bovine serum albumin. Clones that retained wild-type Asn at position 35 showed preferred binding to gitoxin, like the 26-10-RRALD parent. In contrast, clones containing Val-35 selected mainly on digoxin-bovine serum albumin demonstrated a shift back to wild-type specificity. Several clones containing Val-35 bound digoxin with increased affinity, approaching that of the wild type in a few instances, in contrast to the mutation Val-35 in the wild-type 26-10 background, which reduces affinity for digoxin 90-fold. It has therefore proven possible to reorder the 26-10 binding site by mutations including two major contact residues on opposite sides of the site and yet to retain high affinity for binding for digoxin. Thus, even among antibodies that have undergone affinity maturation in vivo, different structural solutions to high affinity binding may be revealed.  (+info)

The effect of dietary fiber on postprandial serum digoxin concentration in man. (2/3)

The postprandial digoxin concentrations in serum were measured for 4 hr by radioimmunological assay in six healthy volunteers who had received 0.8 mg beta-acetyldigoxin by the oral route. Digoxin was given together with a formula diet containing as admixture, respectively, wheat bran, microcrystalline cellulose, pectin, carrageenan, and carob seed flour. The various additions did not reduce the mean digoxin concentrations in serum. After carob seed flour, the concentrations were significantly (P less than 5%) higher, as compared to the control. After microcrystalline cellulose, pectin, and wheat bran the mean peak concentrations were reached later than in the control state.  (+info)

The effect of meloxicam on the pharmacokinetics of beta-acetyl-digoxin. (3/3)

The influence of multiple-dose administration of meloxicam on the pharmacokinetics of oral beta-acetyl-digoxin was studied in 12 healthy male volunteers in a randomized double-blind two-way crossover study. The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8-1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co-treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin.  (+info)

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Castration in weaned calves is stressful and affects profitability by reducing ADG and increasing susceptibility to disease. This study evaluated the effect of meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), on performance and health of calves received as steers compared with bull calves s …
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Cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are heart-arresting. The term derives card- heart (from Greek καρδία kardiā) and the suffix -enolide, referring to the lactone ring at C17. It should not be confused with cardanolides. Cardanolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see MeSH D codes list). Cardenolides are C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone (specifically a butenolide) at C-17. They are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin ...
The aim of this study was to assess knife castration and knife castration + branding in 2-mo-old calves, and the effect of a single dose of s.c. meloxicam at mitigating pain indicators. Seventy-one Angus crossbred bull calves (128 ± 18.5 kg of BW) were used in a 3 × 2 factorial design where main factors included procedure: sham (control calves, CT; n = 23), knife (KN; n = 24) or knife + branding (BK; n = 24), and medication: single s.c. administration of lactated ringer solution (NM; n = 35) or a single dose of 0.5 mg/kg of s.c. meloxicam (M; n = 36). Physiological samples were collected at T0, 60, 90, 120, and 180 min and on days 1, 2, 3, and 7 after procedure, whereas behavioral observations were evaluated at 2 to 4 h and 1, 2, 3, and 7 days after procedure. A procedure × time effect (P , 0.01) was observed for cortisol, where KN and BK calves had greater (P ≤ 0.01) cortisol concentrations than CT calves 60 min after the procedure, whereas BK calves had the greatest (P , 0.05) cortisol ...
TY - JOUR. T1 - Avoiding erroneous serum digoxin concentrations. AU - Murphy, J. E.. AU - Ward, E. S.. AU - Job, M. L.. PY - 1985/12/1. Y1 - 1985/12/1. UR - http://www.scopus.com/inward/record.url?scp=0022180028&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0022180028&partnerID=8YFLogxK. M3 - Letter. C2 - 4073054. AN - SCOPUS:0022180028. VL - 42. SP - 2418. EP - 2420. JO - American Journal of Health-System Pharmacy. JF - American Journal of Health-System Pharmacy. SN - 1079-2082. IS - 11. ER - ...
AF patients starting digoxin treatment showed increased mortality, especially in the first 6 months, irrespective of the coexistence of HF, and digoxin concentrations >1.2 ng/ml should be avoided.
62.5 mcg = 0.0625 mg Example: Based on Table 5,. (0.25 mg) daily of LANOXIN Tablets, usually taken after the morning meal. If no.LANOXIN*0,0625MG 30 CPR: AZIENDA. 0,75-1,5 mg seguiti da 0,25 mg a intervalli di 6 ore fino a ottenere leffetto terapeutico ottimale o,.Mihai Gheorghiade, MD. Valsartan 80 mg bid (n = 4885) Acute MI (0.5 - 10 days). 0.5 0.8 1.0 1.2 1.4 1.6 1.8 2.0 Serum Digoxin Concentration.REAGENTI ORGANICI Descrizione (-). Digoxin DILUENTE PER ANTICORPI. R-PE 0,5 mg REPORTER LYSIS 5X BUFFER RPMI RPMI 1640 10x500 ml.LANOXIN*30CPR 0,0625MG. 2,01. una posologia di 0,0625 mg algiorno (o meno) puo essere sufficiente. Al contrario alcuni pazientipossono richiedere una dose maggiore.. 180 tablet x 0.25mg. I end up just to introduce only affords of the counting England Wales in. The dining room lanoxin you how much I worse or at least the state.lanoxin dosages. In the journal Nature Genetics, researchers from the UK and Germany describe how they found variants in the gene ASAP1 on ...
Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ...
... acetyldigoxins MeSH D09.408.180.261.436.500 - medigoxin MeSH D09.408.180.261.657 - lanatosides MeSH D09.408.180.261.657.200 - ...
... acetyldigoxins MeSH D04.808.155.160.349.350 - digoxigenin MeSH D04.808.155.160.349.500 - medigoxin MeSH D04.808.155.160.861 - ... acetyldigoxins MeSH D04.808.155.580.261.436.500 - medigoxin MeSH D04.808.155.580.261.657 - lanatosides MeSH D04.808.155.580. ...
C01AA01 Acetyldigitoxin C01AA02 Acetyldigoxin C01AA03 Digitalis leaves C01AA04 Digitoxin C01AA05 Digoxin C01AA06 Lanatoside C ... C01AA07 Deslanoside C01AA08 Metildigoxin C01AA09 Gitoformate C01AA52 Acetyldigoxin, combinations C01AB01 Proscillaridin C01AB51 ...
... is a cardiac glycoside. It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. It increases ... α-acetyldigoxin in the ChemIDplus database v t e (Articles needing additional references from August 2007, All articles needing ... The effects of α-acetyldigoxin begin 3-4 hours after administration, and maximize after 6-8 hours. It is prescribed for ...
α-Acetyldigoxin is a cardiac glycoside. It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. It increases ... α-acetyldigoxin in the ChemIDplus database v t e (Articles needing additional references from August 2007, All articles needing ... The effects of α-acetyldigoxin begin 3-4 hours after administration, and maximize after 6-8 hours. It is prescribed for ...
This medicine may cause dizziness, lightheadedness, or fainting, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away. Check with your doctor right away if you become sick while taking this medicine, especially if you have severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water and lead to low blood pressure. You can also loose water by sweating, so drink plenty of water during exercise or in hot weather. Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of ...
Digoxin: Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin ...
Acetyldigoxin ‎]] #[[Alfuzosin ‎]] #[[All signs and symptoms ‎]] #[[Anisometropia ‎]] #[[Anti-glycoprotein-210 antibodies ...
... acetyldigoxin , beta acetyldigoxin , beta-acetyldigoxin , cardiogoxin , digamex , digazolan , digossina , digoxin , digoxina , ...
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... alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43. [Article] ...
Information for 2-amino-5-chlorobenzotrifluoride 445-03-4 including 2-amino-5-chlorobenzotrifluoride CAS NO 445-03-4, 2-amino-5-chlorobenzotrifluoride Suppliers, 2-amino-5-chlorobenzotrifluoride Manufacturers, related products of 2-amino-5-chlorobenzotrifluoride.
Tell your doctor about all other medications you use, especially: Acetyldigoxin, Digitalis, Flecainide, Lithium, Sotalol, ...
Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin ...
Extraction and Quantitation of Digoxin and AcetylDigoxin from the Digitalis lanata Leaf via Near-Supercritical Methanol- ...
Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin ...
VERGIFTUNG MIT NOVODIGAL(BETA -ACETYLDIGOXIN). = LINTOXICATION PAR LE NOVODIGAL(BETA -ACETYLDIGOXINE)ZACH M; BEITZKE A; ...
derivative is acetyldigoxin. Acetyldigoxin. Acetyldigoxin is a cardiac glycoside. It is an acetyl derivative of digoxin. Its ...
Acetyldigoxin a1 peak area of individual impurity impurity a, impurity b, impurity c and impurity d in the chromatogram ...
β-Acetyl Digoxin 1 mg. $650. Add to Cart. 10 mg. $2,200. Add to Cart. ... α-Acetyl Digoxin Synonyms:. (3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-D- ribo-hexopyranosyl-(14)-O-2,6-dideoxy-β-D-ribo- ... hexopyranosyl -(14)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14- dihydroxycard-20(22)-enolide; 3 -Acetyldigoxin; ...
C01AA02 Acetyldigoxin:C01AA03 Digitalis leaves:C01AA04 Digitoxin:C01AA05… … Wikipedia ...
acetyldigoxin. General Information. C01AA02. All the information on this site is from our Global Pharmaceutical Database. ...
Acetyldigoxin. Cardiotonic. Digitalis lanata (foxglove). Allyl isothiocyanate. Rubefaciant. Brassica nigra (black mustard). ...
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12-O-acetyldigoxin 12-O-deacetyl-12-epi-19-deoxy-21-hydroxyscalarin ...
Digoxin: Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin ...
Digoxin: Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin ...
alpha-Acetyldigoxin Narrower Concept UI. M0000183. Registry Number. 0. Terms. alpha-Acetyldigoxin Preferred Term Term UI ... beta-Acetyldigoxin Narrower Concept UI. M0000184. Registry Number. P7K44M64CW. Terms. beta-Acetyldigoxin Preferred Term Term UI ... alpha-Acetyldigoxin beta-Acetyldigoxin digox von ct glycotop Pharm Action. Anti-Arrhythmia Agents. Cardiotonic Agents. Enzyme ... Acetyldigoxins Preferred Term Term UI T000332. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1979). ...
alpha-Acetyldigoxin Narrower Concept UI. M0000183. Registry Number. 0. Terms. alpha-Acetyldigoxin Preferred Term Term UI ... beta-Acetyldigoxin Narrower Concept UI. M0000184. Registry Number. P7K44M64CW. Terms. beta-Acetyldigoxin Preferred Term Term UI ... alpha-Acetyldigoxin beta-Acetyldigoxin digox von ct glycotop Pharm Action. Anti-Arrhythmia Agents. Cardiotonic Agents. Enzyme ... Acetyldigoxins Preferred Term Term UI T000332. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1979). ...
Acetyldigoxins Descriptor Spanish: Acetildigoxinas spanish from Spain Descriptor. acetildigoxinas. Entry term(s). ...
Willow - Aspirin Digitalis lanata (Grecian foxglove, woolly foxglove) - Acetyldigoxin Atropa belladonna - Atropine Papaver ...
... trans-retinoic acid beta-a11-trans-retinoic acids beta acetyldigoxin beta-acetyldigoxin beta acetyldigoxins beta-acetyldigoxins ...
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Digoxin, ?-acetyldigoxin. Cytotoxic treatment has been reported to impair intestinal absorption of digoxin and ?-acetyldigoxin ...
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Chloride N0000167628 Acetylcholinesterase N0000006327 Acetylcysteine N0000168448 Acetyldigitoxins N0000168451 Acetyldigoxins ...
Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ...
Information for N-ETHYL PERFLUOROOCTYLSULFONAMIDE 4151-50-2 including N-ETHYL PERFLUOROOCTYLSULFONAMIDE CAS NO 4151-50-2, N-ETHYL PERFLUOROOCTYLSULFONAMIDE Suppliers, N-ETHYL PERFLUOROOCTYLSULFONAMIDE Manufacturers, related products of N-ETHYL PERFLUOROOCTYLSULFONAMIDE.
It may also decrease excretion rate of acetyldigoxin which further results in higher serum level ...
Acetyldigoxin (a medicine for cardiac disorders): there is a risk that the effect of acetyldigoxin will be reduced;. - ...
D4.808.155.580.130.500.336.259 Acetyldigoxins D4.808.155.580.261.436.50 D4.808.155.580.130.500.436.50 Acidosis, Renal Tubular ...
... trans-retinoic acid beta-a11-trans-retinoic acids beta acetyldigoxin beta-acetyldigoxin beta acetyldigoxins beta-acetyldigoxins ...
Another example is how many cardiotonic drugs like Acetyldigoxin, Digitalin and Digitoxin are derived from constituents from ...
Tell your doctor about all other medications you use, especially: Acetyldigoxin, Digitalis, Flecainide, Lithium, Sotalol, ...
Its corresponding aglycone is digoxigenin, and its acetyl derivative is acetyldigoxin it is widely used in the treatment of ...
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666 ...
  • It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. (wikipedia.org)
  • Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin administration for 7 days at clinical doses. (igmco.ir)
  • The effects of α-acetyldigoxin begin 3-4 hours after administration, and maximize after 6-8 hours. (wikipedia.org)
  • Another example is how many cardiotonic drugs like Acetyldigoxin, Digitalin and Digitoxin are derived from constituents from the Foxglove species of plants ( Digitalis spp. ). (jtnaturopathy.com)