Acetyldigoxins
Encyclopedias as Topic
Cardiac Glycosides
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Digoxin
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
MedlinePlus
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Digitoxin
Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding. (1/3)
Antibody 26-10, obtained in a secondary immune response, binds digoxin with high affinity (K(a) = 1.3 x 10(10) M(-1)) because of extensive shape complementarity. We demonstrated previously that mutations of the hapten contact residue HTrp-100 to Arg (where H refers to the heavy chain) resulted in increased specificity for digoxin analogs substituted at the cardenolide 16 position. However, mutagenesis of H:CDR1 did not result in such a specificity change despite the proximity of the H:CDR1 hapten contact residue Asn-35 to the cardenolide 16 position. Here we constructed a bacteriophage-displayed library containing randomized mutations at H chain residues 30-35 in a 26-10 mutant containing Arg-100 (26-10-RRALD). Phage were selected by panning against digoxin, gitoxin (16-OH), and 16-acetylgitoxin coupled to bovine serum albumin. Clones that retained wild-type Asn at position 35 showed preferred binding to gitoxin, like the 26-10-RRALD parent. In contrast, clones containing Val-35 selected mainly on digoxin-bovine serum albumin demonstrated a shift back to wild-type specificity. Several clones containing Val-35 bound digoxin with increased affinity, approaching that of the wild type in a few instances, in contrast to the mutation Val-35 in the wild-type 26-10 background, which reduces affinity for digoxin 90-fold. It has therefore proven possible to reorder the 26-10 binding site by mutations including two major contact residues on opposite sides of the site and yet to retain high affinity for binding for digoxin. Thus, even among antibodies that have undergone affinity maturation in vivo, different structural solutions to high affinity binding may be revealed. (+info)The effect of dietary fiber on postprandial serum digoxin concentration in man. (2/3)
The postprandial digoxin concentrations in serum were measured for 4 hr by radioimmunological assay in six healthy volunteers who had received 0.8 mg beta-acetyldigoxin by the oral route. Digoxin was given together with a formula diet containing as admixture, respectively, wheat bran, microcrystalline cellulose, pectin, carrageenan, and carob seed flour. The various additions did not reduce the mean digoxin concentrations in serum. After carob seed flour, the concentrations were significantly (P less than 5%) higher, as compared to the control. After microcrystalline cellulose, pectin, and wheat bran the mean peak concentrations were reached later than in the control state. (+info)The effect of meloxicam on the pharmacokinetics of beta-acetyl-digoxin. (3/3)
The influence of multiple-dose administration of meloxicam on the pharmacokinetics of oral beta-acetyl-digoxin was studied in 12 healthy male volunteers in a randomized double-blind two-way crossover study. The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8-1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co-treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin. (+info)Addiction - drug
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Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ...
List of MeSH codes (D09)
... acetyldigoxins MeSH D09.408.180.261.436.500 - medigoxin MeSH D09.408.180.261.657 - lanatosides MeSH D09.408.180.261.657.200 - ...
List of MeSH codes (D04)
... acetyldigoxins MeSH D04.808.155.160.349.350 - digoxigenin MeSH D04.808.155.160.349.500 - medigoxin MeSH D04.808.155.160.861 - ... acetyldigoxins MeSH D04.808.155.580.261.436.500 - medigoxin MeSH D04.808.155.580.261.657 - lanatosides MeSH D04.808.155.580. ...
ATC code C01
C01AA01 Acetyldigitoxin C01AA02 Acetyldigoxin C01AA03 Digitalis leaves C01AA04 Digitoxin C01AA05 Digoxin C01AA06 Lanatoside C ... C01AA07 Deslanoside C01AA08 Metildigoxin C01AA09 Gitoformate C01AA52 Acetyldigoxin, combinations C01AB01 Proscillaridin C01AB51 ...
Α-Acetyldigoxin
... is a cardiac glycoside. It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. It increases ... α-acetyldigoxin in the ChemIDplus database v t e (Articles needing additional references from August 2007, All articles needing ... The effects of α-acetyldigoxin begin 3-4 hours after administration, and maximize after 6-8 hours. It is prescribed for ...
Α-Acetyldigoxin - Wikipedia
α-Acetyldigoxin is a cardiac glycoside. It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. It increases ... α-acetyldigoxin in the ChemIDplus database v t e (Articles needing additional references from August 2007, All articles needing ... The effects of α-acetyldigoxin begin 3-4 hours after administration, and maximize after 6-8 hours. It is prescribed for ...
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Digoxin - AbsoluteAstronomy.com
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β-Acetyl Digoxin 1 mg. $650. Add to Cart. 10 mg. $2,200. Add to Cart. ... α-Acetyl Digoxin Synonyms:. (3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-D- ribo-hexopyranosyl-(14)-O-2,6-dideoxy-β-D-ribo- ... hexopyranosyl -(14)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14- dihydroxycard-20(22)-enolide; 3 -Acetyldigoxin; ...
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MeSH Browser
alpha-Acetyldigoxin Narrower Concept UI. M0000183. Registry Number. 0. Terms. alpha-Acetyldigoxin Preferred Term Term UI ... beta-Acetyldigoxin Narrower Concept UI. M0000184. Registry Number. P7K44M64CW. Terms. beta-Acetyldigoxin Preferred Term Term UI ... alpha-Acetyldigoxin beta-Acetyldigoxin digox von ct glycotop Pharm Action. Anti-Arrhythmia Agents. Cardiotonic Agents. Enzyme ... Acetyldigoxins Preferred Term Term UI T000332. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1979). ...
MeSH Browser
alpha-Acetyldigoxin Narrower Concept UI. M0000183. Registry Number. 0. Terms. alpha-Acetyldigoxin Preferred Term Term UI ... beta-Acetyldigoxin Narrower Concept UI. M0000184. Registry Number. P7K44M64CW. Terms. beta-Acetyldigoxin Preferred Term Term UI ... alpha-Acetyldigoxin beta-Acetyldigoxin digox von ct glycotop Pharm Action. Anti-Arrhythmia Agents. Cardiotonic Agents. Enzyme ... Acetyldigoxins Preferred Term Term UI T000332. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1979). ...
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Digoxin | Profiles RNS
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666 ...
Digoxin2
- It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. (wikipedia.org)
- Meloxicam 15 mg once daily for 7 days did not alter the plasma concentration profile of digoxin after β-acetyldigoxin administration for 7 days at clinical doses. (igmco.ir)
Administration1
- The effects of α-acetyldigoxin begin 3-4 hours after administration, and maximize after 6-8 hours. (wikipedia.org)
Cardiac1
- Acetyldigoxin is a cardiac glycoside. (absoluteastronomy.com)
Digitalis1
- Another example is how many cardiotonic drugs like Acetyldigoxin, Digitalin and Digitoxin are derived from constituents from the Foxglove species of plants ( Digitalis spp. ). (jtnaturopathy.com)