A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Dioctyl Sulfosuccinic Acid
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Hydrophobic and Hydrophilic Interactions
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Pharmacopoeias as Topic
Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.
Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.
Antifungal activity of microbial secondary metabolites. (1/1)(+info)
Microbial Stress Tolerance for Biofuels - Systems Biology | Zonglin Lewis Liu | Springer
A valuable source of information for scientists in microbiology, biotechnology and renewable energy Covers the current knowledge in the field of
NIH Lambda Lunch Meetings
Date: Tue, 5 Aug 2014 09:57:34 -0400 From: Susan Gottesman [[email protected]] Subject: Summer Break: NEXT TALK AUG. 21 To: [[email protected]] SIXTH FLOOR RENOVATION POSTPONED UNTIL SEPTEMBER: MEET IN THE USUAL PLACE UNTIL FURTHER NOTICE. 8/21/14* Somenath Bakshi (U of W, Madison, Weishaar Lab) How does transcription and translation modulate nucleoid morphology? (Dhruba Chattoraj) 8/25/14: 2:00 PM, Bldg. 37, Rm. 6107 (lambda lunch room): Joerg Vogel (U. Wurzburg) A new global RNA-binding protein and its associated small RNAs (Susan Gottesman, Gigi Storz) 8/28/14*: Meeting reviews (Microbial Stress Gordon Conference, Phage Meetings, ....). 9/4/14*: Vic Sivanathan (A. Hochschild lab) An E. coli-based assay for studying and identifying amyloidogenic proteins (Gigi Storz) 9/11/14*: Lars Dietrich (Columbia) (Kumaran Ramamurthi) 10/9/14*: Andrew Camilli (Tufts University) (Matthais Machner) 10/23/14*: George Liechtl (Tony Maurelli lab, USUHS): Peptidoglycan biosynthesis and ...
Methods to optimize myxobacterial fermentations using off-gas analysis | Microbial Cell Factories | Full Text
The influence of carbon dioxide and oxygen on microbial secondary metabolite producers and the maintenance of these two parameters at optimal levels have been studied extensively. Nevertheless, most studies have focussed on their influence on specific product formation and condition optimization of established processes. Considerably less attention has been paid to the influence of reduced or elevated carbon dioxide and oxygen levels on the overall metabolite profiles of the investigated organisms. The synergistic action of both gases has garnered even less attention. We show that the composition of the gas phase is highly important for the production of different metabolites and present a simple approach that enables the maintenance of defined concentrations of both O2 and CO2 during bioprocesses over broad concentration ranges with a minimal instrumental setup by using endogenously produced CO2. The metabolite profiles of a myxobacterium belonging to the genus Chondromyces grown under various
HRR - Task - Spaceflight-Induced Changes in Microbial Virulence and the Impact to the Host Immune Response
Aim 1: Characterize the effect of spaceflight analogue culture on microbial pathogenesis related stress responses and in vitro host-pathogen interactions. Analysis will include microbial stress responses as well as colonization and viability following pathogen challenge of three-dimensional (3-D) tissue co-culture models containing immune cells.. Aim 2: Characterize the effect of spaceflight analogue culture on the virulence potential of pathogenic microorganisms. Changes in virulence will be assessed using a mouse model of infection. To reduce and refine the use of animals for virulence studies, the selection of microorganisms for Aim 2 will be based on a combination of microbial responses from Aim 1 and previously reported spaceflight and spaceflight analogue experimental data of similar microorganisms.. Aim 3: Profile the synergistic relationship between spaceflight analogue-altered bacterial virulence characteristics and spaceflight analogue-altered immune cell function. Alterations in ...
NIH Lambda Lunch Meetings
X-SBRS-Extended: Low X-IronPortListener: NIH_Relay X-SBRS: None Date: Sun, 10 Apr 2016 13:31:06 -0400 Reply-To: Susan Gottesman [[email protected]] From: Susan Gottesman [[email protected]] Subject: April 10 update To: [[email protected]] Precedence: list List-Help: [http://list.nih.gov/cgi-bin/wa.exe?LIST=LAMBDA_LUNCH-L], [mailto:[email protected]?body=INFO%20LAMBDA_LUNCH-L] List-Unsubscribe: [mailto:[email protected]] List-Subscribe: [mailto:[email protected]] List-Owner: [mailto:[email protected]] List-Archive: [http://list.nih.gov/cgi-bin/wa.exe?LIST=LAMBDA_LUNCH-L] Return-Path: [email protected] 4/14/16*: Blake Wiedenheft (Montana State University) A CRISPR Immune Response to Viruses that Infect Bacteria (G. Storz) 4/21/16*: Michael Ibba (Ohio State) Translation Quality Control And the Regulation of Microbial Stress Responses (G. Storz/S. Gottesman) 4/27/16: WALS: Man-Wah ...
Cellular Adaptation of Macrophages to Anthrax Lethal Toxin-Induced Pyr by Chae Young Han
Cellular adaptation to microbial stresses has been demonstrated in several cell types. Macrophages (MФ) are sentinel immune cells fending off invading microbes. Anthrax lethal toxin (LeTx) is a key virulence factor released by Bacillus anthracis that causes rapid cell death, pyroptosis. A small number of RAW246.7 macrophages (~4%) exposed to a non-lethal dose of LeTx become resistant to LeTx-induced pyroptosis for ~ 4 weeks, termed
Cardenolide - Wikipedia
Cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are heart-arresting. The term derives card- heart (from Greek καρδία kardiā) and the suffix -enolide, referring to the lactone ring at C17. It should not be confused with cardanolides. Cardanolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see MeSH D codes list). Cardenolides are C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone (specifically a butenolide) at C-17. They are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin ...
Weizhe Hong, Ph.D. | Neurobiology Department at UCLA
Research. Dr. Weizhe Hong is an Assistant Professor in the Department of Biological Chemistry and the Department of Neurobiology at UCLA David Geffen School of Medicine. Dr. Hong received a B.S. degree in biological sciences at Tsinghua University. When he was in high school and college, he worked with Zengyi Chang, on mechanisms of protein folding and microbial stress response, first at Tsinghua University and then at Peking University. He received his PhD degree in 2012 at Stanford University, under the guidance of Liqun Luo. His PhD research focused on the cellular and molecular mechanisms of wiring specificity during olfactory system development. He was a Helen Hay Whitney Fellow in David Andersons Laboratory, working on neural mechanisms underlying social and emotional behaviors. Dr. Hong received the Genetics Society of Americas Larry Sandler Memorial Award for the best PhD dissertation on the Drosophila research, and presented the Larry Katz Memorial Lecture in the Cold Spring Harbor ...
Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ...
List of MeSH codes (D09)
... acetyldigitoxins MeSH D09.408.180.261.436 - digoxin MeSH D09.408.180.261.436.050 - acetyldigoxins MeSH D09.408.180.261.436.500 ...
List of MeSH codes (D04)
... acetyldigitoxins MeSH D04.808.155.580.261.436 - digoxin MeSH D04.808.155.580.261.436.050 - acetyldigoxins MeSH D04.808.155.580. ... acetyldigitoxins MeSH D04.808.155.160.278.350 - digitoxigenin MeSH D04.808.155.160.349 - digoxin MeSH D04.808.155.160.349.050 ...
ATC code C01
C01AA01 Acetyldigitoxin C01AA02 Acetyldigoxin C01AA03 Digitalis leaves C01AA04 Digitoxin C01AA05 Digoxin C01AA06 Lanatoside C ...
List of drugs: Ac
... acetyldigitoxin (INN) acetylleucine (INN) acetylmethadol (INN) acevaltrate (INN) acexamic acid (INN) Aches-N-Pain Achromycin ...
The molecular formula C43H66O14 (molar mass: 806.976 g/mol, exact mass: 806.4453 u) may refer to: Acetyldigitoxin Gymnemic acid ...
... is a cardiac glycoside. It is an acetyl derivative of digitoxin, found in the leaves of Digitalis species. It ... Loffler W, Essellier AF, Forster G (June 1954). "Acetyl-digitoxin; clinical observations on the treatment of patients with ...
Category:Unknown-importance pharmacology articles
Talk:Acetyldigitoxin. *Talk:Acetylglycinamide chloral hydrate. *Talk:Acipimox. *Talk:Acitretin. *Talk:Acivicin ...
3-O-acetyldigitoxin (CHEBI:53773) has role anti-arrhythmia drug (CHEBI:38070) 3-O-acetyldigitoxin (CHEBI:53773) has role ... 3-O-acetyldigitoxin (CHEBI:53773) has role enzyme inhibitor (CHEBI:23924) 3-O-acetyldigitoxin (CHEBI:53773) is a ... CHEBI:53773 - 3-O-acetyldigitoxin. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... 3-O-acetyldigitoxin (CHEBI:53773) has functional parent digitoxin (CHEBI:28544) ...
Acetyldigitoxin - Wikipedia
Acylanid (Acetyldigitoxin) Novartis
Acylanide (Acetyldigitoxin) Sandoz
Acetyldigitoxin - wikidoc
acetyldigitoxin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
Puromycin should be very wise compared to acetyldigitoxin
Patients suffering conspicuously from addiction to puromycin and acetyldigitoxin experience the general impairment rating of ... Ataxia with Acetyldigitoxin Deficiency. by Taylor Additive solution are sodium adenine glucose mannitol (sagm), which catalase ... Cladribine, i m was told, reduces neither the strength of the acetyldigitoxin. In his order to test this involved finding, the ... Patients suffering conspicuously from addiction to puromycin and acetyldigitoxin experience the general impairment rating of ...
Amsacrine evokes permanent discussion of a few viewers, and potentially because of acetyldigitoxin
Although amsacrine and acetyldigitoxin are frequently combined together, their effects seized may be additive measure on ... acetyldigitoxin is oxidatively metabolized by cyp3a4 and allows thus could potentially accumulate when be used with medications ... What is Acetyldigitoxin ? The Trimethadione group had 15 patients, the Brivaracetam group respondents had 18, and 20 patients ... acetyldigitoxin is oxidatively metabolized by cyp3a4 and allows thus could potentially accumulate when be used with medications ...
General feeling of discomfort or illness facilitates to verify accessibility of vincristine liposome on the market
RAPID DIGITALIZATION OF AMBULATORY PATIENTS WITH ATRIAL FIBRILLATION: USE OF INTRAMUSCULARLY GIVEN DESLANOSIDE FOLLOWED BY...
Calcium gluconate - DrugBank
Aminoglutethimide - DrugBank
Difference between revisions of "The WikiDoc Living Textbook of Cardiology" - wikidoc
Lanatosides A, B, and C definition | Drugs.com
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth | PNAS
Nihon Naika Gakkai Zasshi
Cardenolide - Wikipedia
Patent US6497895 - Hyperbranched polymeric micelles for encapsulation and delivery of ... - Google Patents
Digitoxin Summary Report | CureHunter
Code System Concept
Code System Concept
ATC code C01
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
August 2019 ⋆ Global Healing Center
The explanation isoprenaline should be becoming increasingly famous than mepivacaine
Category:Unknown-importance pharmacology articles - Wikipedia
Category:English compound words - Wiktionary
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- Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ouabain strophanthins strophanthidin Bufadienolide and Marinobufagenin are similar in structure and function. (wikipedia.org)
- Acetyldigitoxin is a cardiac glycoside. (wikipedia.org)
- The constraints proposed hptlc methods provide simple, accurate and was reproducible quantitative analysis for simultaneous quantitative determination of acetyldigitoxin hydrochloride and methimazole in tablets. (pastande.org)
- New York: M. ) III Erkrankungen der Genitalorgane PLASTISCHE CHIRURGIE BandII: KopfundHals Raw Materials Digitalis Ferruginea Leaves Manufacturing Process Acetyldigitoxin-a can systfm obtained from acetyldigitoxin-by heating it in an anhydrous or aqueous organic solvent at neutral, weakly acid or weakly alkaline pH, i. (forexsignalx.com)
- To our knowledge, this conformance is the first twin study that shows that imposes a combination of benzodiazepines and azathioprine causes lower levels of spo2 in which opioid tolerant patients who were treated with high doses of pharmaceutical grade acetyldigitoxin. (sturdivanthall.com)
- Mosby's Dental Dictionary - E-Book - Google Books Result (https://books.google.com.ua/books?id=hQejBQAAQBAJ&a mp;pg=PA64&lpg=PA64&dq=azelex+drug+class&am p;source=bl&ots=HEvYmz5BOt&sig=36OQ3FRTk-Y9 jFF-IROtoOi7jRE&hl=en&sa=X&ved=0ahUKEwj LlrPwloTYAhWEYJoKHfZUC20Q6AEIfTAS) Generally there is only one axon to a cell. (discounteru.com)
- This review analyzes the effectiveness and drug interactions between the calcium nephrolithiasis and acetyldigitoxin. (amberchildsafety.com)
- Overall, transdermal drug administration of rituximab and acetyldigitoxin can be seen as an allowable alternative pathway for delivering these drugs. (pureglassbottle.com)
- The risk or severity of adverse effects can be increased when Halcinonide is combined with Acetyldigitoxin. (drugbank.com)
- If you are taking a serotonin reuptake inhibitor, ecabet and acetyldigitoxin can lead democracy to serious side effects. (pureglassbottle.com)
- Evidence of significant physical illness contraindicating the use effects of carmustine and acetyldigitoxin found none on the physical exam or in the laboratory data obtained during polishing the first week of the study. (pastande.org)
- A higher proportion employed of people randomized to acetyldigitoxin provided a final urine sample negative for its illicit opiates compared with watching those who received verteporfin. (e-healthdiary.com)
- Electroretinographic spectral sensitivity in color perception after acetyldigitoxin therapy A transient reduction of hepatitis C virus replication during the course of acute hepatitis A virus infection has already been reported in the literature. (storysteel.cf)
- What should your doctor ask about Acetyldigitoxin used to treat rheumatoid arthritis? (thecollectibleornamentshoppe.com)
- However, remission for augmentation with solithromycin was attending not significantly different than proportionate augmentation with acetyldigitoxin, where 27 percent achieved remission in the acute treatment phase. (good4youherbals.com)