Acetyldigitoxins: Cardioactive derivatives of lanatoside A or of DIGITOXIN. They are used for fast digitalization in congestive heart failure.Teniposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.Podophyllotoxin: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.Amomum: A plant genus of the family ZINGIBERACEAE. Members contain aculeatin D, beta-sitosterol, and STIGMASTEROL. Some members have been reclassified to ELETTARIA and other ZINGIBERACEAE.Topoisomerase II Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.DNA Topoisomerases, Type II: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Hypercalcemia: Abnormally high level of calcium in the blood.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Receptors, Calcitriol: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.Cyproterone Acetate: An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.Cyproterone: An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.Acne Vulgaris: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.Estradiol Congeners: Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.Antithyroid Agents: Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.Iodides: Inorganic binary compounds of iodine or the I- ion.ThyroglobulinIodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.PeroxidasesThyroid Hormones: Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.Diphtheria Toxin: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Tetanus Toxin: Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.Lymphoma, T-Cell, Cutaneous: A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cardenolides: C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.Cardiac Glycosides: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.Cardanolides: The aglycone constituents of CARDIAC GLYCOSIDES. The ring structure is basically a cyclopentanoperhydrophenanthrene nucleus attached to a lactone ring at the C-17 position.Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)Acetyldigoxins: Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Micelles: Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.Dioctyl Sulfosuccinic Acid: All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)Pharmacopoeias as Topic: Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.Digitalis Glycosides: Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.Digitalis: A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.

Antifungal activity of microbial secondary metabolites. (1/1)

 (+info)

A valuable source of information for scientists in microbiology, biotechnology and renewable energy Covers the current knowledge in the field of
Date: Tue, 5 Aug 2014 09:57:34 -0400 From: Susan Gottesman [[email protected]] Subject: Summer Break: NEXT TALK AUG. 21 To: [[email protected]] SIXTH FLOOR RENOVATION POSTPONED UNTIL SEPTEMBER: MEET IN THE USUAL PLACE UNTIL FURTHER NOTICE. 8/21/14* Somenath Bakshi (U of W, Madison, Weishaar Lab) "How does transcription and translation modulate nucleoid morphology?" (Dhruba Chattoraj) 8/25/14: 2:00 PM, Bldg. 37, Rm. 6107 (lambda lunch room): Joerg Vogel (U. Wurzburg) "A new global RNA-binding protein and its associated small RNAs" (Susan Gottesman, Gigi Storz) 8/28/14*: Meeting reviews (Microbial Stress Gordon Conference, Phage Meetings, ....). 9/4/14*: Vic Sivanathan (A. Hochschild lab) "An E. coli-based assay for studying and identifying amyloidogenic proteins" (Gigi Storz) 9/11/14*: Lars Dietrich (Columbia) (Kumaran Ramamurthi) 10/9/14*: Andrew Camilli (Tufts University) (Matthais Machner) 10/23/14*: George Liechtl (Tony Maurelli lab, USUHS): "Peptidoglycan biosynthesis and ...
X-SBRS-Extended: Low X-IronPortListener: NIH_Relay X-SBRS: None Date: Sun, 10 Apr 2016 13:31:06 -0400 Reply-To: Susan Gottesman [[email protected]] From: Susan Gottesman [[email protected]] Subject: April 10 update To: [[email protected]] Precedence: list List-Help: [http://list.nih.gov/cgi-bin/wa.exe?LIST=LAMBDA_LUNCH-L], [mailto:[email protected]?body=INFO%20LAMBDA_LUNCH-L] List-Unsubscribe: [mailto:[email protected]] List-Subscribe: [mailto:[email protected]] List-Owner: [mailto:[email protected]] List-Archive: [http://list.nih.gov/cgi-bin/wa.exe?LIST=LAMBDA_LUNCH-L] Return-Path: [email protected] 4/14/16*: Blake Wiedenheft (Montana State University) "A CRISPR Immune Response to Viruses that Infect Bacteria" (G. Storz) 4/21/16*: Michael Ibba (Ohio State) "Translation Quality Control And the Regulation of Microbial Stress Responses" (G. Storz/S. Gottesman) 4/27/16: WALS: Man-Wah ...
Cellular adaptation to microbial stresses has been demonstrated in several cell types. Macrophages (MФ) are sentinel immune cells fending off invading microbes. Anthrax lethal toxin (LeTx) is a key virulence factor released by Bacillus anthracis that causes rapid cell death, pyroptosis. A small number of RAW246.7 macrophages (~4%) exposed to a non-lethal dose of LeTx become resistant to LeTx-induced pyroptosis for ~ 4 weeks, termed
Cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are heart-arresting. The term derives card- "heart" (from Greek καρδία kardiā) and the suffix -enolide, referring to the lactone ring at C17. It should not be confused with cardanolides. Cardanolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see MeSH D codes list). Cardenolides are C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone (specifically a butenolide) at C-17. They are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin ...
Research. Dr. Weizhe Hong is an Assistant Professor in the Department of Biological Chemistry and the Department of Neurobiology at UCLA David Geffen School of Medicine. Dr. Hong received a B.S. degree in biological sciences at Tsinghua University. When he was in high school and college, he worked with Zengyi Chang, on mechanisms of protein folding and microbial stress response, first at Tsinghua University and then at Peking University. He received his PhD degree in 2012 at Stanford University, under the guidance of Liqun Luo. His PhD research focused on the cellular and molecular mechanisms of wiring specificity during olfactory system development. He was a Helen Hay Whitney Fellow in David Andersons Laboratory, working on neural mechanisms underlying social and emotional behaviors. Dr. Hong received the Genetics Society of Americas Larry Sandler Memorial Award for the best PhD dissertation on the Drosophila research, and presented the Larry Katz Memorial Lecture in the Cold Spring Harbor ...
Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ...
... acetyldigitoxins MeSH D09.408.180.261.436 --- digoxin MeSH D09.408.180.261.436.050 --- acetyldigoxins MeSH D09.408.180.261. ...
... acetyldigitoxins MeSH D04.808.155.160.278.350 --- digitoxigenin MeSH D04.808.155.160.349 --- digoxin MeSH D04.808.155.160. ... acetyldigitoxins MeSH D04.808.155.580.261.436 --- digoxin MeSH D04.808.155.580.261.436.050 --- acetyldigoxins MeSH D04.808. ...
C01AA01 Acetyldigitoxin C01AA02 Acetyldigoxin C01AA03 Digitalis leaves C01AA04 Digitoxin C01AA05 Digoxin C01AA06 Lanatoside C ...
... acetyldigitoxin (INN) acetylleucine (INN) acetylmethadol (INN) acevaltrate (INN) acexamic acid (INN) Aches-N-Pain Achromycin ...
Talk:Acetyldigitoxin. *Talk:Acetylglycinamide chloral hydrate. *Talk:Acipimox. *Talk:Acitretin. *Talk:Acivicin ...
3-O-acetyldigitoxin (CHEBI:53773) has role anti-arrhythmia drug (CHEBI:38070) 3-O-acetyldigitoxin (CHEBI:53773) has role ... 3-O-acetyldigitoxin (CHEBI:53773) has role enzyme inhibitor (CHEBI:23924) 3-O-acetyldigitoxin (CHEBI:53773) is a ... CHEBI:53773 - 3-O-acetyldigitoxin. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... 3-O-acetyldigitoxin (CHEBI:53773) has functional parent digitoxin (CHEBI:28544) ...
C01AA01 - Acetyldigitoxin. Pharmaceutical companies: manufacturers, researchers, developers, local distributors and suppliers: ...
C01AA01 - Acetyldigitoxin. Pharmaceutical companies: manufacturers, researchers, developers, local distributors and suppliers: ...
Acetyldigitoxin - Acetyldigoxin - Digitalis leaves - Digitoxin - Digoxin - Lanatoside C - Deslanoside - Metildigoxin - ... Acetyldigitoxin is a cardiac glycoside. It is an acetyl derivative of digitoxin. ... Retrieved from "https://www.wikidoc.org/index.php?title=Acetyldigitoxin&oldid=1087026" ...
acetyldigitoxin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
How is Acetyldigitoxin taken in pill form?. Skin Care What are considerations regarding the B complex with c 550mg ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Aminoglutethimide.. Acetyldigoxin. Acetyldigoxin ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Teniposide.. Approved. Acetyldigoxin. Acetyldigoxin ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of 3,3-diindolylmethane.. Acetyldigoxin. ...
Acetyldigitoxin. Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of 2-Methoxyestradiol.. Acetyldigoxin. Acetyldigoxin ...
Acetyldigitoxin. 806.9757. C43H66O14. Used for fast digitalization in congestive heart failure.. Digitalis Glycosides. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of 2-chloroethyl-3-sarcosinamide-1-nitrosourea. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Omacetaxine mepesuccinate.. Acetyldigoxin. ...
Acetyldigitoxin. The risk or severity of adverse effects can be increased when Amikacin is combined with Acetyldigitoxin. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of KRN-7000.. Acetyldigoxin. Acetyldigoxin may ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Coumermycin A1.. Acetyldigoxin. Acetyldigoxin may ...
Acetyldigitoxin. The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is ... combined with Acetyldigitoxin.. Acetyldigoxin. The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be ...
Acetyldigitoxin. Acetyldigitoxin may increase the arrhythmogenic activities of Bioallethrin.. Acetyldigoxin. Acetyldigoxin may ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Cyproterone acetate.. Approved. Acetyldigoxin. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.. Acetyldigoxin. ...
Acetyldigitoxin. The serum concentration of Acetyldigitoxin can be increased when it is combined with Methimazole.. Approved. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of Denileukin diftitox.. Approved. Acetyldigoxin. ...
Acetyldigitoxin. Acetyldigitoxin may decrease the cardiotoxic activities of 10-hydroxycamptothecin.. Acetyldigoxin. ...
Digitalis Glycosides Overview , Acetyldigitoxin , Acetyldigoxin , Digitalis leaves , Digitoxin , Digoxin , Lanatoside C , ... small,Digitalis Glycosides [[Digitalis,Overview]] , [[Acetyldigitoxin]] , [[Acetyldigoxin]] , [[Digitalis]] leaves , [[ ...
  • Mosby's Dental Dictionary - E-Book - Google Books Result (https://books.google.com.ua/books?id=hQejBQAAQBAJ&a mp;pg=PA64&lpg=PA64&dq=azelex+drug+class&am p;source=bl&ots=HEvYmz5BOt&sig=36OQ3FRTk-Y9 jFF-IROtoOi7jRE&hl=en&sa=X&ved=0ahUKEwj LlrPwloTYAhWEYJoKHfZUC20Q6AEIfTAS) Generally there is only one axon to a cell. (discounteru.com)
  • This review analyzes the effectiveness and drug interactions between the calcium nephrolithiasis and acetyldigitoxin. (amberchildsafety.com)