Acetylcholinesterase
Cholinesterase Inhibitors
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Acetylthiocholine
Cholinesterase Reactivators
Electrophorus
Tacrine
Physostigmine
Torpedo
Galantamine
A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
Pralidoxime Compounds
Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.
Sarin
Isoflurophate
Thiocholine
Edrophonium
Electric Organ
In about 250 species of electric fishes, modified muscle fibers forming disklike multinucleate plates arranged in stacks like batteries in series and embedded in a gelatinous matrix. A large torpedo ray may have half a million plates. Muscles in different parts of the body may be modified, i.e., the trunk and tail in the electric eel, the hyobranchial apparatus in the electric ray, and extrinsic eye muscles in the stargazers. Powerful electric organs emit pulses in brief bursts several times a second. They serve to stun prey and ward off predators. A large torpedo ray can produce of shock of more than 200 volts, capable of stunning a human. (Storer et al., General Zoology, 6th ed, p672)
Organothiophosphorus Compounds
Chlorpyrifos
Insecticides
Pyridostigmine Bromide
Soman
Bungarus
Neostigmine
Carbamates
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Phenylcarbamates
Organophosphates
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
Echothiophate Iodide
Tetraisopropylpyrophosphamide
Elapid Venoms
Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.
Oximes
Organophosphate Poisoning
Malathion
Organophosphorus Compounds
Chemical Warfare Agents
Obidoxime Chloride
Butyrylthiocholine
Choline O-Acetyltransferase
Acetylcholine
Trichlorfon
Histocytochemistry
Organothiophosphates
Parathion
Motor Endplate
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Receptors, Cholinergic
Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Pesticides
Binding Sites
Erythrocytes
Nootropic Agents
Dimethoate
Decamethonium Compounds
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Propidium
Why are there so few resistance-associated mutations in insecticide target genes? (1/2082)
The genes encoding the three major targets of conventional insecticides are: Rdl, which encodes a gamma-aminobutyric acid receptor subunit (RDL); para, which encodes a voltage-gated sodium channel (PARA); and Ace, which encodes insect acetylcholinesterase (AChE). Interestingly, despite the complexity of the encoded receptors or enzymes, very few amino acid residues are replaced in different resistant insects: one within RDL, two within PARA and three or more within AChE. Here we examine the possible reasons underlying this extreme conservation by looking at the aspects of receptor and/or enzyme function that may constrain replacements to such a limited number of residues. (+info)Calcitonin gene-related peptide decreases expression of acetylcholinesterase in mammalian myotubes. (2/2082)
Nerve-derived trophic factors are known to modulate expression of acetylcholinesterase (AChE) in skeletal muscle fibers, yet the precise identity of these factors remains elusive. In the present study, we treated mouse C2 myotubes with calcitonin gene-related peptide (CGRP). Compared to non-treated myotubes, cell-associated AChE activity levels were decreased by approximately 60% after 48 h of treatment. A parallel reduction in AChE total protein levels was also observed as determined by Western blot analysis. The reduction in AChE activity was due to a decrease in the levels of the G1 molecular form and to an elimination of G1. By contrast, levels of secreted AChE remained unchanged following CGRP treatment. Finally, the overall decrease in AChE activity was accompanied by a reduction in AChE transcripts which could not be attributed to changes in the transcriptional rate of the ACHE gene. (+info)Monoclonal antibody 3F3 against conformational epitope of Torpedo acetylcholinesterase. (3/2082)
AIM: To study the type of epitope of native Torpedo acetylcholinesterase (AChE) directed by its monoclonal antibody (McAb) 3F3. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used for the assay of the reaction between antigen and antibody. RESULTS: McAb 3F3 immunoreacted well with the native AChE, but not with the reduced- and alkylated-AChE (RA-AChE) at all. Soman did not interfere the binding of 3F3 with AChE molecule. The synthesized 24-peptide containing the active serine residue of the AChE active center did not react with McAb 3F3. CONCLUSION: 3F3 is a monoclonal antibody against the conformational epitope of Torpedo AChE active center, but dose not occupy the active serine residue of the enzyme. (+info)Establishment and characterization of human neuroblastoma cell lines. (4/2082)
Three new tissue culture cell lines, CHP-100, CHP-126, and CHP-134, have been established from explant cultures of human neuroblastoma. The cell lines have been characterized with respect to morphology, chromosomes constitution, growth, neural enzyme content, and their ability to grow in nude mice. The cells grow as dense masses comprised of fibroblast-or neuroblast-like cells with small processes. The cell lines differ in their neural enzyme acitivity. The chromosomal content of the 3 cell lines is near diploid, and all are capable of forming tumors in nude mice. The morphological findings indicate that the cells in culture resemble those found in the tumor, and the enzyme activities are consistent with those of nervous tissue. This the morphological, biochemical, and tumorigenic properties confirm that the 3 cell lines are neoplastic cells of neural origin. (+info)Electron paramagnetic resonance reveals altered topography of the active center gorge of acetylcholinesterase after binding of fasciculin to the peripheral site. (5/2082)
Fasciculin, a peptidic toxin from snake venom, inhibits mammalian and fish acetylcholinesterases (AChE) by binding to the peripheral site of the enzyme. This site is located at the rim of a narrow, deep gorge which leads to the active center triad, located at its base. The proposed mechanisms for AChE inhibition by fasciculin include allosteric events resulting in altered conformation of the AChE active center gorge. However, a fasciculin-induced altered topography of the active center gorge has not been directly demonstrated. Using electron paramagnetic resonance with the spin-labeled organophosphate 1-oxyl-2,2,6, 6-tetramethyl-4-piperidinylethylphosphorofluoridate (EtOSL) specifically bound to the catalytic serine of mouse AChE (mAChE), we show that bound fasciculin on mAChE slows down, but does not prevent phosphorylation of the active site serine by EtOSL and protects the gorge conformation against thermal denaturation. Most importantly, a restricted freedom of motion of the spin label bound to the fasciculin-associated mAChE, compared to mAChE, is evidenced. Molecular models of mAChE and fasciculin-associated mAChE with tethered EtOSL enantiomers indicate that this restricted motion is due to greater proximity of the S-EtOSL nitroxide radical to the W86 residue in the fasciculin-associated enzyme. Our results demonstrate a topographical alteration indicative of a restricted conformation of the active center gorge of mAChE with bound fasciculin at its rim. (+info)Organophosphorylation of acetylcholinesterase in the presence of peripheral site ligands. Distinct effects of propidium and fasciculin. (6/2082)
Structural analysis of acetylcholinesterase (AChE) has revealed two sites of ligand interaction in the active site gorge: an acylation site at the base of the gorge and a peripheral site at its mouth. A goal of our studies is to understand how ligand binding to the peripheral site alters the reactivity of substrates and organophosphates at the acylation site. Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. Rate constants obtained with human erythrocyte AChE were in good agreement with those obtained for recombinant human AChE produced from a high level Drosophila S2 cell expression system. First-order rate constants kOP were 1,600 +/- 300 min-1 for DEPQ and 150 +/- 11 min-1 for EMPC, and second-order rate constants kOP/KOP were 193 +/- 13 microM-1 min-1 for DEPQ and 0.7-1.0 +/- 0.1 microM-1 min-1 for EMPC. Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates. Such modest inhibitory effects are consistent with our recently proposed steric blockade model (Szegletes, T., Mallender, W. D., and Rosenberry, T. L. (1998) Biochemistry 37, 4206-4216). Moreover, the binding of propidium resulted in a clear increase in kOP for EMPC, suggesting that molecular or electronic strain caused by the proximity of propidium to EMPC in the ternary complex may promote phosphorylation. In contrast, the binding of the polypeptide neurotoxin fasciculin to the peripheral site of AChE dramatically decreased phosphorylation rate constants. Values of kOP/KOP were decreased by factors of 10(3) to 10(5), and kOP was decreased by factors of 300-4,000. Such pronounced inhibition suggested a conformational change in the acylation site induced by fasciculin binding. As a note of caution to other investigators, measurements of phosphorylation of the fasciculin-AChE complex by AChE inactivation gave misleading rate constants because a small fraction of the AChE was resistant to inhibition by fasciculin. (+info)Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. (7/2082)
Acetylcholinesterase (AChE) occurs in both asymmetric forms, covalently associated with a collagenous subunit called Q (ColQ), and globular forms that may be either soluble or membrane associated. At the skeletal neuromuscular junction, asymmetric AChE is anchored to the basal lamina of the synaptic cleft, where it hydrolyzes acetylcholine to terminate synaptic transmission. AChE has also been hypothesized to play developmental roles in the nervous system, and ColQ is also expressed in some AChE-poor tissues. To seek roles of ColQ and AChE at synapses and elsewhere, we generated ColQ-deficient mutant mice. ColQ-/- mice completely lacked asymmetric AChE in skeletal and cardiac muscles and brain; they also lacked asymmetric forms of the AChE homologue, butyrylcholinesterase. Thus, products of the ColQ gene are required for assembly of all detectable asymmetric AChE and butyrylcholinesterase. Surprisingly, globular AChE tetramers were also absent from neonatal ColQ-/- muscles, suggesting a role for the ColQ gene in assembly or stabilization of AChE forms that do not themselves contain a collagenous subunit. Histochemical, immunohistochemical, toxicological, and electrophysiological assays all indicated absence of AChE at ColQ-/- neuromuscular junctions. Nonetheless, neuromuscular function was initially robust, demonstrating that AChE and ColQ do not play obligatory roles in early phases of synaptogenesis. Moreover, because acute inhibition of synaptic AChE is fatal to normal animals, there must be compensatory mechanisms in the mutant that allow the synapse to function in the chronic absence of AChE. One structural mechanism appears to be a partial ensheathment of nerve terminals by Schwann cells. Compensation was incomplete, however, as animals lacking ColQ and synaptic AChE failed to thrive and most died before they reached maturity. (+info)Cloning, expression, and properties of a nonneuronal secreted acetylcholinesterase from the parasitic nematode Nippostrongylus brasiliensis. (8/2082)
We have isolated a full-length cDNA encoding an acetylcholinesterase secreted by the nematode parasite Nippostrongylus brasiliensis. The predicted protein is truncated in comparison with acetylcholinesterases from other organisms such that the carboxyl terminus aligns closely to the end of the catalytic domain of the vertebrate enzymes. The residues in the catalytic triad are conserved, as are the six cysteines which form the three intramolecular disulfide bonds. Three of the fourteen aromatic residues which line the active site gorge in the Torpedo enzyme are substituted by nonaromatic residues, corresponding to Tyr-70 (Thr), Trp-279 (Asn), and Phe-288 (Met). High level expression was obtained via secretion from Pichia pastoris. The purified enzyme behaved as a monomeric hydrophilic species. Although of invertebrate origin and possessing the above substitutions in the active site gorge residues, the enzyme efficiently hydrolyzed acetylthiocholine and showed minimal activity against butyrylthiocholine. It displayed excess substrate inhibition with acetylthiocholine at concentrations over 2. 5 mM and was highly sensitive to both active site and "peripheral" site inhibitors. Northern blot analysis indicated a progressive increase in mRNA for AChE B in parasites isolated from 6 days postinfection. (+info)
Correlation of Red Blood Cell Acetylcholinesterase Enzyme Activity with Various RBC Indices<...
Correlation of Red Blood Cell Acetylcholinesterase Enzyme Activity with Various RBC Indices MAHE Digital Repository
COLQ collagen like tail subunit of asymmetric acetylcholinesterase [Homo sapiens (human)] - Gene - NCBI
AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro. - Free Online Library
Stabilization of collagen-tailed acetylcholinesterase in muscle cells through extracellular anchorage by transglutaminase...
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations | BMC Ecology and...
Acetylcholinesterase - definition of acetylcholinesterase by The Free Dictionary
EFFECT OF YISHENJIANGZHUO DECOCTION ON INTRACEREBRAL ACHE ACTIVITY OF ISCHEMIA REPERFUSION RAT--《Journal of Chengde...
Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesterase<...
Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer | Clinical...
ANTIBODIES TO ACETYLCHOLINESTERASE | PNAS
5hfa - Proteopedia, life in 3D
eCite - Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid...
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1ut6 - Proteopedia, life in 3D
COOH-terminal collagen Q (COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of...
Cholinesterase - wikidoc
Acetylcholinesterase (4E11) Antibody | Abbiotec
CSEMP assessment of acetylcholine esterase activity in biota at station Severn SeInter fi01
Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment.
HKU Scholars Hub: A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on...
RCSB PDB
- 2HA4: Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with acetylcholine...
Bovine acetylcholinesterase: cloning, expression and characterization | Biochemical Journal
Features of Acetylcholinesterase Rapid Staining Kit | MBL Life Sience -ASIA
Mouse (Murine) Acetylcholinesterase (AChE) Protein, Recombinant | ABIN6301593
Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia
Research Article: Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors - Chromoscience
Purification and characterization of acetylcholinesterase from the Lake Van fish (Chalcalburnus tarichii Pallas, 1811) | AVESİS
Human brain acetylcholinesterase - ORA - Oxford University Research Archive
Remediated Sequence
- 2JGJ: Crystal structure of mouse acetylcholinesterase inhibited by aged methamidophos Sequence...
Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by...
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates |...
Marine Drugs | Free Full-Text | Insights and Ideas Garnered from Marine Metabolites for Development of Dual-Function...
COLQ Gene - GeneCards | COLQ Protein | COLQ Antibody
Vol 14: Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect. - pdf descargar
Developmental changes in the distribution of acetylcholinesterase in the extrastriate visual cortex of the monkey. - Semantic...
Plus it
Interaction of Acetylcholinesterase with Neurexin-1β regulates Glutamatergic Synaptic stability in Hippocampal neurons |...
Acetylcholinesterase抗体[HR2]|Abcam中国|Anti-Acetylcholinesterase抗体[HR2]
Výsledky VaV - VUT v Brně
Acetylcholinesterase - Wikipedia
Cannabis May Slow Brain Aging - Democratic Underground
Acetylcholinesterase inhibitor | Project Gutenberg Self-Publishing - eBooks | Read eBooks online
Question about acetylcholinesterase inhibitors, cog function
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The combined effect of Bassa 50EC and Vitashield 40EC on the brain acetylcholinesterase activity in climbing perch (Anabas...
Quantitative regulation of acetylcholinesterase development in the muscle lineage cells of cleavage-arrested ascidian embryos |...
acetylcholinesterase inhibitors drugs
Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential...
Exposure to radio-frequency electromagnetic waves alters acetylcholinesterase gene expression, exploratory and motor...
Treatment of Alzheimers disease with acetylcholinesterase inhibitors: Bridging the gap between evidence and practice<...
Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase
Fluoride Action Network | Effect of vitamin D on chronic behavioral and dental toxicities of sodium fluoride in rats.
Galanthamine HBr| CAS#1953-04-4 | 1953-04-4 | Alkaloid acetylcholinesterase inhibitor | MedKoo
Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Silico Molecular Docking Studies<...
Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. - Semantic Scholar
Pralidoxime • LITFL • Toxicology Library Antidotes
Simple general acid-base catalysis of physiological acetylcholinesterase reactions<...
Huperzine A - Herzon Laboratory
mean acetylcholinesterase levels in the lungs of guinea pigs | Zanran
Factors Associated with Response to Acetylcholinesterase Inhibition in Dementia:A Cohort Study from a Secondary Mental Health...
Potential use of acetylcholinesterase, glutathione-S-transferase and metallothionein for assessment of contaminated sediment in...
IO Rodeo Inc. | Smart lab technology
Academic Journals
Effects of Dietary Pb and Cd and Their Combination on Acetyl Cholinesterase Activity in Digestive Gland and Foot of the Green...
Inhibition of Acetylcholinesterase Activity in the Golden Apple Snail (Pomacea canaliculata Lamarck) Exposed to Chlorpyrifos,...
Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE...
Plasma acetylcholinesterase activity correlates with intracerebral β-amyloid load
Too Much Tacrine?
Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of...
Beyond Pesticides Daily News Blog Carbamates Archives - Beyond Pesticides Daily News Blog
Altered glycosylation of acetylcholinesterase in the Alzheimer disease brain: involvement of alfa7 nicotinic acetylcholine...
Sensors | Free Full-Text | Acetylcholinesterase Immobilized on Magnetic Beads for Pesticides Detection: Application to Olive...
ReP USP - Detalhe do registro: Acetylcholinesterase capillary enzyme reactor for screening and characterization of selective...
Pre-invasion history and demography shape the genetic variation in the insecticide resistance-related acetylcholinesterase 2...
Dokument bez názvu
CBRNE - Nerve Agents, V-series - Ve, Vg, Vm, Vx: Background, Pathophysiology, Epidemiology
Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains in: Acta Biologica...
Jose Tormos | Ciencia Puerto Rico
Acetylcholinesterase Inhibition by Biofumigant (Coumaran) from Leaves of Lantana camara in Stored Grain and Household Insect...
Molecular model of VX nerve gas - Stock Image A700/0123 - Science Photo Library
Avoiding TragedyMy heart aches at the tragedy of John... - tribunedigital-baltimoresun
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VX - Simple English Wikipedia, the free encyclopedia
Anomalies on capture nets of Hydropsyche slossonae larvae (Trichoptera; Hydropsychidae), a potential indicator of chronic...
Globules of fat - Wikipedia
IQ Brain Function | Neuro By Nature ™
HUP 13 - AdisInsight
Acetylcholine and its enzymes in some brain areas of the rat under stress<...
Proteopedia
"Acetylcholinesterase". Proteopedia. "Hemoglobin". Proteopedia. "Photosystem II". Proteopedia. Luiggi C (September 2010). "Web ... as well as pages that are more descriptive of protein structures in general such as acetylcholinesterase, hemoglobin, and the ...
Phenylalanine N-acetyltransferase
Leuzinger W, Baker AL, Cauvin E (1968). "Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point". Proc. ...
Modes of toxic action
Acetylcholinesterase (AChE) inhibitors. AChE is an enzyme associated with nerve synapses that it's designed to regulate nerve ... see Acetylcholinesterase inhibitors). Irritants. These are chemicals that cause an inflammatory effect on living tissue by ...
List of OMIM disorder codes
MSH6 Endplate acetylcholinesterase deficiency; 603034; COLQ Enhanced S-cone syndrome; 268100; NR2E3 Enlarged vestibular ...
Minaprine
In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. Fung M, Thornton ... Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG (February 1999). "Aminopyridazines as acetylcholinesterase ...
Cholinesterase inhibitor
English, Brett A.; Webster, Andrew A. (2012). "Acetylcholinesterase and its Inhibitors". Primer on the Autonomic Nervous System ... This group of inhibitors is divided into two subgroups, acetylcholinesterase inhibitors (AChEIs) and butyrylcholinesterase ... Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. In 2015, the United ... "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology". Current Neuropharmacology. Bentham Science Publishers Ltd. 11 (3 ...
N,N-Dimethyl-2-chloro-2-phenylethylamine
Acetylcholinesterase inhibitor Weise, C; Kreienkamp, HJ; Raba, R; Pedak, A; Aaviksaar, A; Hucho, F (December 1990). "Anionic ... N,N-Dimethyl-2-chloro-2-phenylethylamine is chemical compound that irreversibly inhibits the acetylcholinesterase. This ... "Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom". Proceedings of the ... DPA binds to the anionic site of acetylcholinesterase, where it alkylates and irreversibly inhibits the enzyme. ...
Management of schizophrenia
Singh, J; Kour, K; Jayaram, MB (January 2012). "Acetylcholinesterase inhibitors for schizophrenia". Cochrane Database of ...
Enzyme inhibitor
Acetylcholinesterase (AChE) is an enzyme found in animals, from insects to humans. It is essential to nerve cell function ... Other artificial enzyme inhibitors block acetylcholinesterase, an enzyme which breaks down acetylcholine, and are used as nerve ... Hostettmann K, Borloz A, Urbain A, Marston A (2006). "Natural Product Inhibitors of Acetylcholinesterase". Current Organic ... The organophosphate pesticides such as malathion, parathion, and chlorpyrifos irreversibly inhibit acetylcholinesterase. The ...
Physostigma venenosum
"Acetylcholinesterase Inhibitors: Pharmacology and Toxicology". Current Neuropharmacology. 11 (3): 315-335. doi:10.2174/ ...
Carbamate
Other carbamate based acetylcholinesterase inhibitors are known with even higher toxicity to humans, and some such as T-1123 ... Besides inhibiting human acetylcholinesterase (although to a lesser degree than the insect enzyme), carbamate insecticides also ... These insecticides kill insects by reversibly inactivating the enzyme acetylcholinesterase (IRAC mode of action 1a). The ... The insect repellent icaridin is a substituted carbamate.[citation needed] While the carbamate acetylcholinesterase inhibitors ...
Pesticide
They affect the nervous system of target pests (and non-target organisms) by disrupting acetylcholinesterase activity, the ... Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM (May 2013). "Acetylcholinesterase inhibitors: pharmacology and ... Studies show that farm workers in Ethiopia, Kenya, and Zimbabwe have decreased concentrations of plasma acetylcholinesterase, ... For example, many studies investigating exposure to pesticides often involve the quantification of the acetylcholinesterase ...
Corydaline
... is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo. Xiao, Hai-Tao; Peng, Jiao; Liang, Yan; Yang, ... Jie; Bai, Xue; Hao, Xiao-Yan; Yang, Fu-Mei; Sun, Qian-Yun (September 2011). "Acetylcholinesterase inhibitors from Corydalis ...
Corydalis yanhusuo
It also contains the acetylcholinesterase inhibitor corydaline. N-Methyltetrahydroprotoberberines have been isolated from C. ... "Acetylcholinesterase inhibitors from Corydalis yanhusuo". Natural Product Research. Taylor and Francis. 25 (15): 1418-1422. doi ...
Diisopropylphosphate
... is an acetylcholinesterase inhibitor. It acts by covalently binding to acetylcholinesterase. Diisopropyl- ...
EA-3990
Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM (May 2013). "Acetylcholinesterase inhibitors: pharmacology and ... It is lethal because it inhibits acetylcholinesterase. Inhibition causes an overly high accumulation of acetylcholine between ...
Malathion
... is an acetylcholinesterase inhibitor, a diverse family of chemicals. Upon uptake into the target organism, it binds ... Malathion is an organophosphate insecticide which acts as an acetylcholinesterase inhibitor. In the USSR, it was known as ... Its metabolite malaoxon is 61x more toxic, being a more potent inhibitor of acetylcholinesterase. According to the United ... "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology". Current Neuropharmacology. 11 (3): 315-335. doi:10.2174/ ...
VX (nerve agent)
VX is an acetylcholinesterase inhibitor. It works by blocking the function of acetylcholinesterase (AChE). Normally, when a ... The reaction products of acetylcholinesterase with VX before and after the "aging" reaction were solved near atomic resolution ... of acetylcholinesterase. VX has a very high "on-rate" to react with the target enzyme and form a stable P-O-C bond ( ... "Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad". Journal of the American ...
Chlorethoxyfos
... by inhibiting acetylcholinesterase (AChE). The function of acetylcholinesterase is to break down the neurotransmitter ... Organophosphorus compounds inhibit acetylcholinesterase by forming a covalent bond between the compound and the active site of ... By inhibiting acetylcholinesterase, acetylcholine accumulates in the synaptic cleft, reaching toxic levels. Loss of AChE ... Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM (May 2013). "Acetylcholinesterase inhibitors: pharmacology and ...
Sleep and memory
Physostigmine is an acetylcholinesterase inhibitor; it is a drug that inhibits the breakdown of the inhibitory neurotransmitter ... 0.6 words when participants were given the acetylcholinesterase inhibitor. Conversely, neither speed nor accuracy declined in ...
Lupinine
This leads to the formation of an enzyme-sorption complex with the anionic portion of the acetylcholinesterase located on the ... Studies on the hydrochloride of lupinine have shown it to be a reversible inhibitor of acetylcholinesterases. Lupinine, a ... At physiological pH, the amine of lupinine is protonated which leads to ion-ion interaction with the acetylcholinesterase ... Studies have shown that lupinine hydrochloride is a mildly toxic acetylcholinesterase inhibitor and that lupinine has an ...
Ethoprophos
Acetylcholinesterase inhibition in plasma happened at a dose of 100 mg/kg/day. For short-term inhalation, a study was done with ... The results showed a NOAEL of 0.025 mg/kg/day and the acetylcholinesterase inhibition in plasma occurred at a dose of 0.075 mg/ ... It is used as an insecticide and nematicide and it is an acetylcholinesterase inhibitor. Ethoprop can be synthesised by ... Another target of ethoprophos is erythrocyte acetylcholinesterase. The only known location of this enzyme is on the outside of ...
Chelidonine
AChE (acetylcholinesterase) inhibitors or anti-cholinesterases inhibit the enzyme cholinesterase from breaking down ACh, ... Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). ... Journal of Molecular Structure, 734(1-3), 1-6. Colovic, M. B. (2013). Acetylcholinesterase Inhibitors: Pharmacology and ... Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase inhibitory activity. Chelidonine ...
Phorate
It inhibits acetylcholinesterase and butyrylcholinesterase. Phorate is most commonly applied in granular form. It is non- ...
Corydalis mucronifera
Acetylcholinesterase inhibitors are currently prescribed to those with neurodegenerative disorders, as research suggests that ... dos Santos, Thaiane Coelho; Gomes, Thaís Mota (2018). "Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential ... Čolović, Mirjana B; Krstić, Danijela Z (May 2013). "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology". Current ... researchers found that these compounds exhibited high levels of acetylcholinesterase inhibitory activity. Being inhibitors of ...
Alkaloid
inhibitor of acetylcholinesterase Quinidine antiarrhythmic Quinine antipyretic, antimalarial Reserpine antihypertensive ...
Physostigmine
It is a reversible inhibitor of acetylcholinesterase, the enzyme responsible for the breakdown of acetylcholine in the synaptic ... Physostigmine's poor tolerability led to it being abandoned in favor of later acetylcholinesterase inhibitors, three of which ... Its mechanism is to prevent the hydrolysis of acetylcholine by acetylcholinesterase at the transmitted sites of acetylcholine. ... Mehta M, Adem A, Sabbagh M (2012). "New acetylcholinesterase inhibitors for Alzheimer's disease". International Journal of ...
Indole alkaloid
Physostigmine is a reversible acetylcholinesterase inhibitor. Plants and fungi that contain indole alkaloids have a long ... Physostigmine - an inhibitor of acetylcholinesterase - and its synthetic analogs are used in the treatment of glaucoma, ...
Gulf War syndrome
Golomb BA (March 2008). "Acetylcholinesterase inhibitors and Gulf War illnesses". Proc. Natl. Acad. Sci. U.S.A. 105 (11): 4295- ...
Caffeine
... also affects the cholinergic system where it is a moderate inhibitor of the enzyme acetylcholinesterase. Caffeine from ... Karadsheh, Naif; Kussie, Paul; Linthicum, D.Scott (March 1991). "Inhibition of acetylcholinesterase by caffeine, anabasine, ... Pohanka, Miroslav; Dobes, Petr (8 May 2013). "Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase". ...
Acetylcholinesterase inhibitor - Wikipedia
An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the ... Comparison of reversible acetylcholinesterase inhibitors Inhibitor Duration Main site of action Clinical use Adverse effects ... Acetylcholinesterase+inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Wang, BS; Wang, H; Wei, ZH; Song, YY; Zhang, L; Chen, HZ (2009). "Efficacy and safety of natural acetylcholinesterase inhibitor ...
ANTIBODIES TO ACETYLCHOLINESTERASE | PNAS
In an in vitro system, activity of the commercial enzyme or of highly purified acetylcholinesterase was inhibited by 70-82 per ... A rabbit antiserum against commercially available Electrophorus electricus acetylcholinesterase has been prepared. Five ... ANTIBODIES TO ACETYLCHOLINESTERASE. R. Michael Williams. PNAS April 1, 1969 62 (4) 1175-1180; https://doi.org/10.1073/pnas.62.4 ... demonstrated by the absence of serological cross reactions or enzyme inhibition with bovine erythrocyte acetylcholinesterase or ...
Acetylcholinesterase - Wikipedia
In mammals, acetylcholinesterase is encoded by a single AChE gene while some invertebrates have multiple acetylcholinesterase ... inhibitors AChE bivalent inhibitors Acetylcholinesterase: A gorge-ous enzyme-PDBe Acetylcholinesterase-RCSB PDB Human ACHE ... and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant". J. Biol. ... "Entrez Gene: ACHE acetylcholinesterase (Yt blood group)". Dori A, Ifergane G, Saar-Levy T, Bersudsky M, Mor I, Soreq H, Wirguin ...
Acetylcholinesterase inhibitor - Wikipedia
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase ... Acetylcholinesterase inhibitors: Occur naturally as venoms and poisons (e.g onchidal) Are used as weapons (nerve agents) Are ... Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase ... Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ (April 2009). "Efficacy and safety of natural acetylcholinesterase inhibitor ...
Acetylcholinesterase - definition of acetylcholinesterase by The Free Dictionary
acetylcholinesterase synonyms, acetylcholinesterase pronunciation, acetylcholinesterase translation, English dictionary ... definition of acetylcholinesterase. n. An enzyme in the blood and in certain tissues that catalyzes the hydrolysis of ... Related to acetylcholinesterase: Acetylcholinesterase inhibitors. a·ce·tyl·cho·li·nes·ter·ase. (ə-sēt′l-kō′lə-nĕs′tə-rās′, -rāz ... acetylcholinesterase. Also found in: Thesaurus, Medical, Legal, Acronyms, Encyclopedia, Wikipedia. ...
Acetylcholinesterase of Cerebral Microvessels Changes in Alzheimer's Disease | SpringerLink
Acetylcholinesterase (AChE) is histochemically demonstrable in capillary basement membranes of brain regions that contain ... Acetylcholinesterase (AChE) is histochemically demonstrable in capillary basement membranes of brain regions that contain ... AChE Activity Alzheimer Brain Sucrose Density Gradient Acetylcholinesterase Activity Sedimentation Coefficient These keywords ... Kreutzberg, G. W., Tóth L., and Kaiya, H., 1975, Acetylcholinesterase as a marker for dendritic transport and dendritic ...
Inhibition of mammalian acetylcholinesterase by phenylmethanesulfonyl fluoride. - PubMed - NCBI
The Glycolipid-Addition Signal of Acetylcholinesterase | SpringerLink
Various types of acetylcholinesterase (AChE) subunits are characterized by specific C-terminal peptides. In Torpedoand mammals ... Various types of acetylcholinesterase (AChE) subunits are characterized by specific C-terminal peptides. In Torpedo and mammals ... Bon S., Coussen F., Massoulié J. (1998) The Glycolipid-Addition Signal of Acetylcholinesterase. In: Doctor B.P., Taylor P., ... The Glycolipid-Addition Signal of Acetylcholinesterase. Cellular Compartmentation, Cleavage, GPI Addition and Secretion ...
Central Acetylcholinesterase Inhibitor
... , Acetylcholinesterase Inhibitor, Cholinesterase Inhibitor, Anticholinesterase. ... Central Acetylcholinesterase Inhibitor. Aka: Central Acetylcholinesterase Inhibitor, Acetylcholinesterase Inhibitor, ... Central cholinesterase inhib, Central acetylcholinesterase inhibitor, Central acetylcholinesterase inhibitor (product), Central ... acetylcholinesterase inhibitor (substance). Spanish. inhibidor central de la acetilcolinesterasa (producto), inhibidor central ...
Acetylcholinesterase OTTHUMP00000211347 - definition of acetylcholinesterase OTTHUMP00000211347 by The Free Dictionary
... acetylcholinesterase OTTHUMP00000211347 translation, English dictionary definition of acetylcholinesterase OTTHUMP00000211347. ... redirected from acetylcholinesterase OTTHUMP00000211347). Also found in: Thesaurus, Medical, Encyclopedia. ache. (āk). intr.v. ... Acetylcholinesterase OTTHUMP00000211347 - definition of acetylcholinesterase OTTHUMP00000211347 by The Free Dictionary https:// ... Define acetylcholinesterase OTTHUMP00000211347. acetylcholinesterase OTTHUMP00000211347 synonyms, acetylcholinesterase ...
Unbalanced acetylcholinesterase activity in larynx squamous cell carcinoma. - PubMed - NCBI
RCSB PDB - 1AX9: ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, LAUE DATA
ACETYLCHOLINESTERASE. A. 537. Tetronarce californica. Mutation(s): 0 Gene Names: ache. EC: 3.1.1.7. ... Static Laue diffraction studies on acetylcholinesterase.. Ravelli, R.B., Raves, M.L., Ren, Z., Bourgeois, D., Roth, M., Kroon, ... Acetylcholinesterase (AChE) is one of natures fastest enzymes, despite the fact that its three-dimensional structure reveals ... Acetylcholinesterase (AChE) is one of natures fastest enzymes, despite the fact that its three-dimensional structure reveals ...
Acetylcholinesterase inhibitor
An acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme ... Comparison of reversible acetylcholinesterase inhibitors Inhibitor Duration[1] Main site of action[1] Clinical use[1] Adverse ... An acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme from breaking ... It uses material from the Wikipedia article "Acetylcholinesterase_inhibitor". A list of authors is available in Wikipedia. ...
Anti-Acetylcholinesterase antibody [4E11] (ab17774)
Mouse monoclonal Acetylcholinesterase antibody [4E11] validated for WB, ELISA and tested in Human. Referenced in 1 publication ... Monoclonal antibodies against a C-terminal peptide of human brain acetylcholinesterase distinguish between erythrocyte and ... Synthetic peptide corresponding to Human Acetylcholinesterase aa 574-583.. Sequence: TDTLDEA ERQ ... brain acetylcholinesterases.. Clin Chem 42:19-23 (1996). Read more (PubMed: 8565226) » ...
RCSB PDB - 6XYS: Update of native acetylcholinesterase from Drosophila Melanogaster
Acetylcholinesterase. A. 581. Drosophila melanogaster. Mutation(s): 0 Gene Names: Ace, CG17907. EC: 3.1.1.7. ... Here, we present updated crystal structures of Drosophila melanogaster acetylcholinesterase ( Dm AChE) originally published in ... Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors.. ...
Haute Autorité de Santé - ARICEPT (donepezil), acetylcholinesterase inhibitors
Autorité publique indépendante à caractère scientifique, la Haute Autorité de santé (HAS) vise à développer la qualité dans le champ sanitaire, social et médico-social, au bénéfice des personnes. Elle travaille aux côtés des pouvoirs publics dont elle éclaire la décision, avec les professionnels pour optimiser leurs pratiques et organisations, et au bénéfice des usagers dont elle renforce la capacité à faire des choix., Insufficient clinical benefit: these medicinal products no longer have a role in the treatment of Alzheimers disease
Reactivators of Organophosphorous Inhibited Acetylcholinesterase | Southwest Research Institute
Alpha Fetoprotein (Amniotic Fluid) with Reflex to Acetylcholinesterase
Acetylcholinesterase peptide (601-614) (ab45700) References
Spina Bifida Workup: Approach Considerations, Urine Studies, Alpha-Fetoprotein and Acetylcholinesterase
Ache - Acetylcholinesterase precursor - Rattus norvegicus (Rat) - Ache gene & protein
AcetylcholinesteraseAdd BLAST. 583. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view. ... acetylcholinesterase activity Source: RGDInferred from direct assayi*. "Cholinesterase activity in the hypoglossal nucleus of ... "Differential localization of acetylcholinesterase in neuronal and non-neuronal cells.". Thullbery M.D., Cox H.D., Schule T., ... "Differential localization of acetylcholinesterase in neuronal and non-neuronal cells.". Thullbery M.D., Cox H.D., Schule T., ...
Glyphosate as an acetylcholinesterase inhibitor in Cnesterodon
Acetylcholinesterase inhibitor treatment for myasthenia gravis | Cochrane
Acetylcholinesterase inhibitor treatment for myasthenia gravis. Review question We reviewed the evidence about the effect of ... An enzyme called acetylcholinesterase breaks down acetylcholine. Some drugs that are used to treat myasthenia gravis act on ... The response to acetylcholinesterase inhibitors in observational studies is so clear that a randomised controlled trial ... The trial compared neostigmine (an acetylcholinesterase inhibitor) given via the nose, with placebo. Each treatment was given ...
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. | Sigma-Aldrich
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.. [Lev Weiner, Valery L Shnyrov, Leonid ... Elucidation of the 3D structures of complexes of Torpedo californica acetylcholinesterase with a repertoire of reversible ... The effects of these three categories of reversible inhibitors on the stability of Torpedo californica acetylcholinesterase ... Stabilization of Torpedo californica acetylcholinesterase by both divalent cations and chemical chaperones was earlier shown to ...
Molecules | Free Full-Text | High Efficiency Acetylcholinesterase Immobilization on DNA Aptamer Modified Surfaces
We report here the in vitro selection of DNA aptamers for electric eel acetylcholinesterase (AChE). One selected aptamer ... High Efficiency Acetylcholinesterase Immobilization on DNA Aptamer Modified Surfaces. Orada Chumphukam, Thao T. Le and Anthony ... We report here the in vitro selection of DNA aptamers for electric eel acetylcholinesterase (AChE). One selected aptamer ... "High Efficiency Acetylcholinesterase Immobilization on DNA Aptamer Modified Surfaces." Molecules 19, no. 4: 4986-4996. ...
Phytochemicals Content, Antioxidant Activity and Acetylcholinesterase Inhibition Properties of Indigenous Garcinia parvifolia...
The free-radical scavenging, ferric reducing, and acetylcholinesterase inhibition effect of the flesh were higher as compared ... Phytochemicals Content, Antioxidant Activity and Acetylcholinesterase Inhibition Properties of Indigenous Garcinia parvifolia ... and antioxidant and acetylcholinesterase inhibition activity of the flesh and peel of G. parvifolia. All samples were freeze- ...
Phytochemicals Content, Antioxidant Activity and Acetylcholinesterase Inhibition Properties of Indigenous Garcinia parvifolia...
Molecules | Free Full-Text | Why is Aged Acetylcholinesterase So Difficult to Reactivate? | HTML
This reaction is called aging and produces an anionic phosphyl adduct with acetylcholinesterase that is refractory to ... Consequently, the evolutionary mechanisms that have led to transition state stabilization in acetylcholinesterase catalysis are ... discussed herein, as are the challenges that they present to reactivation of aged acetylcholinesterase. ... Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The ...
Acetylcholinesterase/ACHE Research Products: Novus Biologicals
Browse our Acetylcholinesterase/ACHE product catalog backed by our Guarantee+. ... PTMs for Acetylcholinesterase/ACHE. Learn more about PTMs related to Acetylcholinesterase/ACHE.. Phosphorylation. Cleavage. ... Diseases related to Acetylcholinesterase/ACHE. Discover more about diseases related to Acetylcholinesterase/ACHE.. Alzheimers ... Bioinformatics Tool for Acetylcholinesterase/ACHE. Discover related pathways, diseases and genes to Acetylcholinesterase/ACHE. ...
Acetylcholinesterase/ACHE Mouse anti-Human, Bovine, Janelia Fluor 646,
| Fisher Scientific
Shop a large selection of products and learn more about Acetylcholinesterase/ACHE Mouse anti-Human, Bovine, Janelia Fluor 646, ... acetylcholinesterase, acetylcholinesterase (Yt blood group), AChE, apoptosis-related acetylcholinesterase, ARACHE, EC 3.1.1, EC ... Acetylcholinesterase/ACHE Monoclonal antibody specifically detects Acetylcholinesterase/ACHE in Human, Bovine samples. It is ... Acetylcholinesterase/ACHE Mouse anti-Human, Bovine, Janelia Fluor 646, Clone: 400000000000, Novus Biologicals ...
Inhibition of AcetylcholinesteraseEnzyme acetylcholinesteraseAcetylcholineColorimetricDual binding site acetylcholinesterase inActivityCholinesteraseInhibitHuman brain acetylcholinesteraseBovineBuChEAntigenOrganophosphate-inhibited acetylcholinesteraseCharacterizationDonepezilForm of AcetylcholinesteraseEffects of acetylcholinesteraseAntibodyResiduesMouse AcetylcholinesteraseAChEIVitroRCSB PDBErythrocyteButyrylcholinesterase inhibitorsAlzheimer's DiseaseDimeric FormTorpedoPeptideEnzymesELISA KitsBChEVenomsSerumHydrolyzesGalantamineNerveBrainPeripheral bindPotent inhibitors
Inhibition of Acetylcholinesterase6
- Although the etiology of Alzheimer's disease (AD) is not fully understood, nevertheless, inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity has been accepted as an effective treatment/management strategy against mild AD [6, 7]. (thefreedictionary.com)
- Fingerman, "Inhibition of acetylcholinesterase activity in the central nervous system of the red swamp crayfish, Procambarus clarkii, by mercury, cadmium, and lead," Bulletin of Environmental Contamination and Toxicology, vol. (thefreedictionary.com)
- The primary mechanism of action for organophosphorus (OP) insecticides involves the inhibition of acetylcholinesterase (AChE) by active oxon metabolites. (cdc.gov)
- A dynamic combinatorial library composed of interconverting acylhydrazones has been generated and screened towards inhibition of acetylcholinesterase from the electric ray Torpedo marmorata. (diva-portal.org)
- Inhibition of acetylcholinesterase (AChE) from head of honey bee (Apis mellifera L.) by organophosphate and carbamate insecticides was developed from Ellman reaction and analyzed by spectrophotometer at the wave length of 412 nm. (fao.org)
- The inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) causes acute toxicity or death of the intoxicated individual. (ovid.com)
Enzyme acetylcholinesterase3
- Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. (wikipedia.org)
- Here, we developed method for assay of neurotoxic pesticides via inhibition of enzyme acetylcholinesterase (AChE) and coloration measuring through an optical fiber. (omicsonline.org)
- The effects of chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test. (usgs.gov)
Acetylcholine13
- An acetylcholinesterase inhibitor (often abbreviated AChEI ) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine , thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. (wikipedia.org)
- An acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme from breaking down acetylcholine , so increasing both the level and duration of action of the neurotransmitter acetylcholine. (bionity.com)
- An enzyme called acetylcholinesterase breaks down acetylcholine. (cochrane.org)
- Some drugs that are used to treat myasthenia gravis act on acetylcholinesterase to stop the breakdown of acetylcholine. (cochrane.org)
- These acetylcholinesterase inhibitors increase the amount of acetylcholine available and so help muscle activation and contraction. (cochrane.org)
- Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. (thermofisher.com)
- Acetylcholinesterase (AChE) is an enzyme that breaks down and deactivates acetylcholine (ACh) after it is released by terminal buttons. (alleydog.com)
- Acetylcholinesterase, or ACHE, hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. (novusbio.com)
- Acetylcholinesterase (AChE) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. (ovid.com)
- Currently, the most widely prescribed treatment for AD is acetylcholinesterase inhibitor medications, which work by partially blocking the degradation of acetylcholine in the synapse and enabling more of the neurotransmitter to reach and activate cholinergic receptors. (eurekaselect.com)
- Acetylcholinesterase inhibitors increase parasympathetic neurotransmission through inhibition of the enzymatic breakdown of acetylcholine at cholinergic receptor sites in the autonomic nervous system. (bmj.com)
- The concentration dependence of activity towards the natural substrate acetylcholine is almost identical for the two enzymes, whereas substrate inhibition of chicken acetylcholinesterase is somewhat weaker than that of the Torpedo enzyme. (aspetjournals.org)
- Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to terminate nerve signaling by rapid hydrolysis of the neurotransmitter acetylcholine. (diva-portal.org)
Colorimetric2
- Acetylcholinesterase Inhibitor Screening Kit (Colorimetric) from BIOVISION, INC. (linscottsdirectory.com)
- Search, find, compare suppliers for Acetylcholinesterase Inhibitor Screening Kit (Colorimetric) products. (linscottsdirectory.com)
Dual binding site acetylcholinesterase in1
- In this study, we have employed in silico methodology combining double pharmacophore based screening, molecular docking, and ADME/T filtering to identify dual binding site acetylcholinesterase inhibitors that can preferentially inhibit acetylcholinesterase and simultaneously inhibit the butyrylcholinesterase also but in the lesser extent than acetylcholinesterase. (amrita.edu)
Activity41
- In an in vitro system, activity of the commercial enzyme or of highly purified acetylcholinesterase was inhibited by 70-82 per cent after incubation with antiserum. (pnas.org)
- Acetylcholinesterase (AChE) is histochemically demonstrable in capillary basement membranes of brain regions that contain relatively high AChE activity in their neuronal elements (Kreutzberg et al. (springer.com)
- Unbalanced acetylcholinesterase activity in larynx squamous cell carcinoma. (nih.gov)
- Fifty paired pieces of larynx squamous cell carcinoma and adjacent non-cancerous tissue were compared in terms of their acetylcholinesterase activity (AChE). (nih.gov)
- Influence of estrogen on acetylcholinesterase activity in primary. (ingentaconnect.com)
- To estimate the influence of estrogen on the functional development of the central nervous system during the neonatal period, several doses of estradiol-17β (E 2 ) were treated to cultured cells from the cerebral cortex of neonatal rats and the acetylcholinesterase (AChE) activity was examined. (ingentaconnect.com)
- The toxic effect of sublethal concentrations (1, 17.5 and 35 mg L(-1)) of pure glyphosate was evaluated on acetylcholinesterase (AChE) activity in the fish species, Cnesterodon decemmaculatus. (greenmedinfo.com)
- Acetylcholinesterase activity and neurodevelopment in boys and girls. (sigmaaldrich.com)
- The present study was conducted to determine the phytochemicals content (total phenolic, flavonoid, anthocyanin, and carotenoid content) and antioxidant and acetylcholinesterase inhibition activity of the flesh and peel of G. parvifolia . (hindawi.com)
- Acetylcholinesterase/ACHE Activity. (novusbio.com)
- Incubation of synaptosomal plasma membranes (SPM) with liposomes of phosphatidylserine (PS), phosphatidylinositol (PIN) or phosphatidylglycerol (PGL), led to an increase of acetylcholinesterase (AchE) activity at concentrations of 0.1-1 mumol phospholipids per mg SPM protein. (nih.gov)
- They found that "TP administration dramatically inhibited AChE [acetylcholinesterase] activity (71% inhibition) as compared to the control. (life-enhancement.com)
- What compounds increase acetylcholinesterase activity? (healthtap.com)
- A drug to reduce the activity of acetylcholinesterase. (healthtap.com)
- Result Among the numerous endophytic fungi, we identified two strains, L10Q37 and LQ2F02, that have anti-acetylcholinesterase activity, but the active compound was not huperzine A. The aim of this study was to investigate the anti-acetylcholinesterase activity of secondary metabolites isolated from the endophytic fungi of Huperzia serrata . (scielo.cl)
- In conclusion, endophytic fungal strains were found in H. serrata that had the same anti-acetylcholinesterase activity. (scielo.cl)
- After tested anti acetylcholinesterase activity, S5 has the best activity. (scielo.cl)
- Other compounds' anti acetylcholinesterase activity was not better compared with huperzine A. (scielo.cl)
- In the present study, the effects during 1.5, 6 and 9-month periods of chronic ingestion of uranyl nitrate (UN) in drinking water (40 mg of uranium per litre) on cholinergic acetylcholinesterase (AChE) activity and on dopaminergic and serotoninergicmetabolisms were investigated in several areas of male Sprague Dawley rat brains. (irsn.fr)
- 1. The erythrocyte membrane acetylcholinesterase activity is significantly (P less than 0.001) decreased in insulin-dependent diabetes mellitus. (portlandpress.com)
- Approximately 150/o of the total acetylcholinesterase (AChE) activity of pig brain cortex can be extracted in dilute buffer solution and the properties of this »soluble« form of the enzyme have been compared with the membrane bound enzyme which was brought into solution by extraction with 1-0/o Triton X-100 or 1 mM EDTA. (srce.hr)
- 29 participants with clinical AD and 35 with non-AD diagnoses underwent positron emission tomography (PET) with the amyloid ligand [11C] PIB and plasma measurements of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity. (pubmedcentralcanada.ca)
- Similar results were found for analyses with the actual level of acetylcholinesterase activity. (bmj.com)
- CONCLUSION The results suggest the presence of a relation between exposure and acetylcholinesterase inhibition, acetylcholinesterase activity, and respiratory, eye, and central nervous system symptoms. (bmj.com)
- The equilibrium constant for the reaction of diethylphosphofluoridate with acetylcholinesterase was evaluated by measuring the second-order rate constant for the inhibition of the enzyme and the second-order rate constant for the restoration of enzyme activity, starting with inhibited enzyme and using fluoride as a reactivator. (aspetjournals.org)
- The synthesis and the biological activity of compounds 5-40 as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca(2+) channels and nicotinic receptors, are described. (ub.edu)
- s ( 1961 ) method was followed to estimate the activity of acetylcholinesterase of insects. (bioone.org)
- Crude spider venom also significantly inhibited the estimated activity of acetylcholinesterase in M . domestica and Ae . (bioone.org)
- It is concluded from the study that both plant extracts and spider venom inhibited the activity of acetylcholinesterase in M . domestica and Ae . (bioone.org)
- The activity of acetylcholinesterase (AChE) and the density of muscarinic cholinergic binding receptors (mCBR) were measured in brains from normal Japanese quail ( Coturnix coturnix japonica ) and from quail after lethal intoxication with diazinon. (bioone.org)
- The acetylcholinesterase activity of sympathetic ganglia (superior cervical, stellate, thoracic chain, superior mesenteric, celiac and cardiac) from immunosympathectomized and control rats was visualized by the histochemical method of Koelle. (aspetjournals.org)
- Contrary to cat sympathetic ganglia, the cells with marked and moderate acetylcholinesterase activity predominate in the sympathetic ganglia of control rats. (aspetjournals.org)
- In the various sympathetic ganglia studied in this investigation, cells with slight acetylcholinesterase activity made up only 3.8 to 10.3% of the total cell populations. (aspetjournals.org)
- No predominant survival of cells with marked acetylcholinesterase activity took place after immunosympathectomy. (aspetjournals.org)
- Nerve growth factor antiserum treatment destroyed cells with marked, moderate and slight acetylcholinesterase activity, and a small number of cells of each type persisted. (aspetjournals.org)
- These experimental observations do not support our previous postulate that the small percentage of cells surviving antiserum treatment are those with marked acetylcholinesterase activity, which may be considered the cholinergic sympathetic cells. (aspetjournals.org)
- However since these medications have limited effectiveness, alternate treatments that focus on augmenting the activity of the receptors themselves, independent of acetylcholinesterase inhibition, are being explored. (eurekaselect.com)
- BioVision's Acetylcholinesterase Inhibitor Screening Kit can be used to screen for potential inhibitors of AChE activity. (linscottsdirectory.com)
- The normal acetylcholinesterase activity from bee head was 33,645+-3,008 mUnit/g(protein) or 88.23 mUnit/bee head. (fao.org)
- Firstly, they are inefficient in the restoration of brain acetylcholinesterase (AChE) activity due to a hard blood-brain barrier penetration. (eurekaselect.com)
- Some embryos of Ciona intestinalis which were permanently cleavage-arrested with cytochalasin B at the 1-cell, 4-cell, or 8-cell stages produced, after 12 or 16 h of development time (18 °C), a level of muscle acetylcholinesterase activity equal to that found in normal early and later larval stage embryos of the same age. (biologists.org)
Cholinesterase3
- Antibody specificity was demonstrated by the absence of serological cross reactions or enzyme inhibition with bovine erythrocyte acetylcholinesterase or horse serum cholinesterase. (pnas.org)
- the other being butyryl-cholinesterase inhibitors.Acetylcholinesterase is the primary member of the cholinesterase enzyme family. (wikipedia.org)
- Walujo B. Prijono and Frederick A. Leighton "Parallel Measurement of Brain Acetylcholinesterase and the Muscarinic Cholinergic Receptor in the Diagnosis of Acute, Lethal Poisoning by Anti-Cholinesterase Pesticides," Journal of Wildlife Diseases 27(1), 110-115, (1 January 1991). (bioone.org)
Inhibit2
- This chapter discusses toxins from Mamba venoms that inhibit acetylcholinesterase. (strath.ac.uk)
- In our quest to find new inhibitors able to inhibit acetylcholinesterase (AChE) and, at the same time, to protect neurons from beta amyloid toxicity, i.e., inhibitors interacting with the catalytic anionic subsite as well as with the peripherical anionic site of AChE, a virtual screening of the Centre d'Etudes et de Recherche sur le Mdicament de Normandie (CERMN) chemical library was carried out. (chemaxon.com)
Human brain acetylcholinesterase2
Bovine3
- Acetylcholinesterase/ACHE Monoclonal antibody specifically detects Acetylcholinesterase/ACHE in Human, Bovine samples. (fishersci.com)
- C-terminal 10 residues of brain acetylcholinesterase (human and bovine), absent from the erythrocyte enzyme. (fishersci.com)
- The bovine acetylcholinesterase (BoAChE) gene was cloned from genomic DNA and its structure was determined. (biochemj.org)
BuChE2
- These compounds are moderate acetylcholinesterase and butyrylcholinesterase inhibitors, the BuChE/AChE selectivity of the most active molecules ranges from 10.0 (compound 29) to 76.9 (compound 16). (ub.edu)
- A series of berberine-thiophenyl hybrids were designed, synthesised, and evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and β-amyloid (Aβ) aggregation and as antioxidants. (unboundmedicine.com)
Antigen1
- The MA3-042 antigen is purified human cerebellar acetylcholinesterase. (thermofisher.com)
Organophosphate-inhibited acetylcholinesterase1
- The present invention relates to organophosphate-inhibited acetylcholinesterase (AChE) reactivators with central nervous system (CNS) bioavailability and their associated methods of preparation including their use for treatment of exposure to AChE inhibitors such as an organophosphate (OP) insecticides and nerve agents. (swri.org)
Characterization2
- The main goal of this study is the application of systematic strategies of characterization in order to optimize the biocomposite composition based on graphite-epoxy that incorporates acetylcholinesterase (AChE) on the matrix. (thefreedictionary.com)
- Chemical and pharmacological characterization of galanthamine, and acetylcholinesterase inhibitor , and its derivates. (thefreedictionary.com)
Donepezil4
- Patients with a low UPSIT score who were assigned to donepezil showed a mean 10.4point improvement on the Selective Reminding Test, while those with an UPSIT score of 30 or more showed a 2.7-point improvement in response to the acetylcholinesterase inhibitor. (thefreedictionary.com)
- In a study of 202 patients, those who continued treatment with the acetylcholinesterase inhibitor donepezil had significant improvements in their scores on the Neuropsychiatric Inventory, even when their scores on the Mini-Mental State Examination (MMSE) were stagnant or had declined. (thefreedictionary.com)
- Sustained treatment with the acetylcholinesterase inhibitor donepezil significantly reduced health care costs for patients with Alzheimer's disease in a Medicare-managed care organization plan, Jerrold W. (thefreedictionary.com)
- The double-blind, randomized trial is the first to examine the effect of the Nmethyl-D-aspartate (NMDA) receptor antagonist memantine and the acetylcholinesterase inhibitor donepezil against donepezil monotherapy, said Dr. (thefreedictionary.com)
Form of Acetylcholinesterase1
- The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. (thermofisher.com)
Effects of acetylcholinesterase2
- Increased latency in the treated animals, i.e., delayed entry into the dark compartment (as compared to nontreated animals) after previous shock, is a measure of the memory-enhancing effects of acetylcholinesterase inhibitors. (life-enhancement.com)
- To characterise the effects of acetylcholinesterase inhibition with pyridostigmine on parasympathetic tone in patients with chronic heart failure (CHF). (bmj.com)
Antibody4
- The following product was used in this experiment: Acetylcholinesterase Monoclonal Antibody (HR2) from Thermo Fisher Scientific, catalog # MA3-042, RRID AB_325478. (thermofisher.com)
- Immunocytochemistry/ Immunofluorescence: Acetylcholinesterase/ACHE Antibody [NB100-1519] - Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. (novusbio.com)
- Flow Cytometry: Acetylcholinesterase/ACHE Antibody [NB100-1519] - Flow cytometric analysis of paraformaldehyde fixed HeLa cells (blue line), permeabilized with 0.5% Triton. (novusbio.com)
- This Acetylcholinesterase/ACHE antibody is validated for IHC-FrFl from a verified customer review. (novusbio.com)
Residues1
- it is suggested that the absence, in the chicken enzyme, of two aromatic residues, Tyr-70 and Trp-279, that contribute to the peripheral site of Torpedo acetylcholinesterase is responsible for the differential effects of peripheral site ligands on the two enzymes. (aspetjournals.org)
Mouse Acetylcholinesterase1
- Mouse Acetylcholinesterase/ACHE EL. (novusbio.com)
AChEI1
- This feature makes acetylcholinesterase inhibitors (AChEi) the main class of drugs currently used for the treatment of AD dementia phase, among which galantamine is the only naturally occurring substance. (frontiersin.org)
Vitro2
- We report here the in vitro selection of DNA aptamers for electric eel acetylcholinesterase (AChE). (mdpi.com)
- AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro. (thefreelibrary.com)
RCSB PDB1
- The June 2004 RCSB PDB Molecule of the Month feature on Acetylcholinesterase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_6 . (proteopedia.org)
Erythrocyte1
- Erythrocyte acetylcholinesterase in Hirschsprung's disease. (bmj.com)
Butyrylcholinesterase inhibitors1
- The best acetylcholinesterase and butyrylcholinesterase inhibitors pharmacophore hypotheses Hypo1_A and Hypo1_B, with high correlation coefficient of 0.96 and 0.94, respectively, were used as 3D query for screening the Zinc database. (amrita.edu)
Alzheimer's Disease3
- Tsuji T., Mimori Y., Nakamura S. (1990) Acetylcholinesterase of Cerebral Microvessels Changes in Alzheimer's Disease. (springer.com)
- A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor , in patients with mild to moderately severe Alzheimer's disease. (thefreedictionary.com)
- Asante R. Kamkwalala and Paul A. Newhouse, "Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease", Current Alzheimer Research (2017) 14: 377. (eurekaselect.com)
Dimeric Form1
- The dimeric form of Torpedo californica acetylcholinesterase provides a valuable experimental system for studying transitions between native, partially unfolded, and unfolded states since long-lived partially unfolded states can be generated by chemical modification of a nonconserved buried cysteine residue, Cys 231, by denaturing agents, by oxidative stress, and by thermal inactivation. (sigmaaldrich.com)
Torpedo5
- Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. (sigmaaldrich.com)
- The effects of these three categories of reversible inhibitors on the stability of Torpedo californica acetylcholinesterase were investigated using spectroscopic techniques and differential scanning calorimetry. (sigmaaldrich.com)
- Stabilization of Torpedo californica acetylcholinesterase by both divalent cations and chemical chaperones was earlier shown to be due to a shift in equilibrium between the native state and a partially unfolded state ( Millard et al. (sigmaaldrich.com)
- Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase. (aspetjournals.org)
- Two bisquaternary ligands, decamethonium and 1,5-bis(4-allydimethylammoniumphenyl)pentan-3-one dibromide, which are believed to bridge the anionic subsite of the active site and the "peripheral" anionic site, are much weaker inhibitors of the chicken enzyme than of Torpedo acetylcholinesterase, whereas the shorter bisquaternary ligand hexamethonium inhibits the two enzymes similarly. (aspetjournals.org)
Peptide1
- Synthetic peptide corresponding to Human Acetylcholinesterase aa 574-583. (abcam.com)
Enzymes1
- Acetylcholinesterase (AChE) is one of nature's fastest enzymes, despite the fact that its three-dimensional structure reveals its active site to be deeply sequestered within the molecule. (rcsb.org)
ELISA Kits1
- 34 Acetylcholinesterase (AChE) ELISA Kits from 12 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
BChE2
- acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) has widely been used as biomarkers to evaluate the noxious effects of pesticides i.e. (thefreedictionary.com)
- The predominant cholinesterases are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). (pubmedcentralcanada.ca)
Venoms1
- Acetylcholinesterase inhibitors: Occur naturally as venoms and poisons (e.g onchidal) Are used as weapons (nerve agents) Are used as insecticides (e.g malathion) Are used medicinally: To treat myasthenia gravis. (wikipedia.org)
Serum1
- Since many possible reasons exist for false-positive results, a presumptive diagnosis based on maternal serum AFP is confirmed with amniocentesis and assay of the amniotic fluid for AFP, as well as for the presence of acetylcholinesterase, a nerve-specific enzyme. (medscape.com)
Hydrolyzes1
- Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it. (novusbio.com)
Galantamine2
- It is also believed that galantamine may be an acetylcholinesterase inhibitor , as well as an allosteric modulator of nicotinic receptors. (thefreedictionary.com)
- In a 12-week, double-blind, placebo-controlled, randomized trial, the acetylcholinesterase inhibitor galantamine had an insignificant overall effect on a composite of neuropsychological outcomes among 44 patients who received it, compared with 42 who got placebo. (thefreedictionary.com)
Nerve4
- Organophosphorous and carbamates kill honeybees through the inactivation of acetylcholinesterase (AChE), thereby interfering with nerve signaling and function. (biomedsearch.com)
- A new magnetic electrochemical immunoassay has been developed as a tool for biomonitoring exposures to organophosphate (OP) compounds, e.g., insecticides and chemical nerve agents, by directly detecting organophosphorylated acetylcholinesterase (OP-AChE). (cdc.gov)
- When the acetylcholinesterase (AChE) reaction was performed subsequently to the GIF reaction the following nerve types could be identified: 1. (biomedsearch.com)
- Point-of-care monitoring of acetylcholinesterase (AChE) is of significant importance for pesticide poisoning and disease diagnosis because it plays a pivotal role in biological nerve conduction systems. (rsc.org)
Brain1
- D.T. Plummer, C.A. Reavill i C.H.S. McIntosh, "Properties of the Soluble and Membrane-Bound Forms of Acetylcholinesterase Present in Pig Brain", Croatica Chemica Acta , vol.47, br. (srce.hr)
Peripheral bind1
- Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. (cdc.gov)