Rhizobium etli: A species of gram-negative bacteria and nitrogen innoculant of PHASEOLUS VULGARIS.Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.Carboxyl and Carbamoyl Transferases: A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Biotin: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Coenzyme ACoenzymes: Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Acetate Kinase: An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.Acetates: Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.Phosphate Acetyltransferase: An enzyme that catalyzes the synthesis of acetylphosphate from acetyl-CoA and inorganic phosphate. Acetylphosphate serves as a high-energy phosphate compound. EC 2.3.1.8.Acetyltransferases: Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1.Coenzyme A Ligases: Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.Coenzyme AInterleukin-1: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.Ribulose-Bisphosphate Carboxylase: A carboxy-lyase that plays a key role in photosynthetic carbon assimilation in the CALVIN-BENSON CYCLE by catalyzing the formation of 3-phosphoglycerate from ribulose 1,5-biphosphate and CARBON DIOXIDE. It can also utilize OXYGEN as a substrate to catalyze the synthesis of 2-phosphoglycolate and 3-phosphoglycerate in a process referred to as photorespiration.Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Phosphoenolpyruvate Carboxylase: An enzyme with high affinity for carbon dioxide. It catalyzes irreversibly the formation of oxaloacetate from phosphoenolpyruvate and carbon dioxide. This fixation of carbon dioxide in several bacteria and some plants is the first step in the biosynthesis of glucose. EC 4.1.1.31.Rhizobium etli: A species of gram-negative bacteria and nitrogen innoculant of PHASEOLUS VULGARIS.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Carboxyl and Carbamoyl Transferases: A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Biotin: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.Carboxyl and Carbamoyl Transferases: A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Rhizobium etli: A species of gram-negative bacteria and nitrogen innoculant of PHASEOLUS VULGARIS.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Carbon-Nitrogen Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Carbon-Carbon Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Biotin: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.Ligases: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.Lactation: The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.Molecular Weight: The sum of the weight of all the atoms in a molecule.Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Amino Acyl-tRNA Synthetases: A subclass of enzymes that aminoacylate AMINO ACID-SPECIFIC TRANSFER RNA with their corresponding AMINO ACIDS.Glutamate-Ammonia Ligase: An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Coenzyme ADictionaries, ChemicalLigases: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Crotonates: Derivatives of BUTYRIC ACID that include a double bond between carbon 2 and 3 of the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.Deltaproteobacteria: A group of PROTEOBACTERIA represented by morphologically diverse, anaerobic sulfidogens. Some members of this group are considered bacterial predators, having bacteriolytic properties.Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Phosphate Acetyltransferase: An enzyme that catalyzes the synthesis of acetylphosphate from acetyl-CoA and inorganic phosphate. Acetylphosphate serves as a high-energy phosphate compound. EC 2.3.1.8.Glucosamine 6-Phosphate N-Acetyltransferase: An enzyme that catalyses the reaction of D-glucosamine 6-phosphate with ACETYL-COA to form N-acetylglucosamine 6-phosphate.Acetate Kinase: An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.Cyclohexanecarboxylic AcidsBenzoates: Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Acetates: Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Acetyl-CoA Carboxylase: A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.Metabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)Pyruvate Carboxylase: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Ribulose-Bisphosphate Carboxylase: A carboxy-lyase that plays a key role in photosynthetic carbon assimilation in the CALVIN-BENSON CYCLE by catalyzing the formation of 3-phosphoglycerate from ribulose 1,5-biphosphate and CARBON DIOXIDE. It can also utilize OXYGEN as a substrate to catalyze the synthesis of 2-phosphoglycolate and 3-phosphoglycerate in a process referred to as photorespiration.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Estersalpha-Macroglobulins: Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Kinetics: The rate dynamics in chemical or physical systems.
(1/885) Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism.

Conversion of serotonin to N-acetylserotonin, the precursor of the circadian neurohormone melatonin, is catalyzed by serotonin N-acetyltransferase (AANAT) in a reaction requiring acetyl coenzyme A (AcCoA). AANAT is a globular protein consisting of an eight-stranded beta sheet flanked by five alpha helices; a conserved motif in the center of the beta sheet forms the cofactor binding site. Three polypeptide loops converge above the AcCoA binding site, creating a hydrophobic funnel leading toward the cofactor and serotonin binding sites in the protein interior. Two conserved histidines not found in other NATs are located at the bottom of the funnel in the active site, suggesting a catalytic mechanism for acetylation involving imidazole groups acting as general acid/base catalysts.  (+info)

(2/885) Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men.

Pyruvate dehydrogenase activity (PDHa) and acetyl-group accumulation were examined in the inactive deltoid muscle in response to maximal leg exercise in men. Seven subjects completed three consecutive 30-s bouts of maximal isokinetic cycling, with 4-min rest intervals between bouts. Biopsies of the deltoid were obtained before exercise, after bouts 1 and 3, and after 15 min of rest recovery. Inactive muscle lactate (LA) and pyruvate (PYR) contents increased more than twofold (P < 0.05) after exercise (bout 3) and remained elevated after 15 min of recovery (P < 0.05). Increased PYR accumulation secondary to LA uptake by the inactive deltoid was associated with greater PDHa, which progressively increased from 0.71 +/- 0.23 mmol. min-1. kg wet wt-1 at rest to a maximum of 1.83 +/- 0.30 mmol. min-1. kg wet wt-1 after bout 3 (P < 0.05) and remained elevated after 15 min of recovery (1.63 +/- 0.24 mmol. min-1. kg wet wt-1; P < 0.05). Acetyl-CoA and acetylcarnitine accumulations were unaltered. Increased PDHa allowed and did not limit the oxidation of LA and PYR in inactive human skeletal muscle after maximal exercise.  (+info)

(3/885) Replenishment and depletion of citric acid cycle intermediates in skeletal muscle. Indication of pyruvate carboxylation.

The effects of various substrates on the concentrations of free amino acids, citric acid cycle intermediates and acylcarnitines were studies in perfused hindquarter of rat in presence of glucose and insulin in order to assess regulatory mechanisms of the level of citric acid cycle intermediates in skeletal muscle. 1. Acetate and acetoacetate effected a significant increase in the level of citrate cycle intermediates and accumulation of acetylcarnitine. These changes were accompanied by a reduction in the level of alanine. The concentration of AMP was significantly elevated. 2. Muscle mitochondria fixed 14CO2 in the presence of pyruvate. The products were identified as malate or citrate when whole and disintegrated mitochondria were used respectively. The fixation was greatly stimulated by acetylcarnitine. 3. Acetylcarnitine inhibited the production of pyruvate from malate by muscle mitochondria. 4. Perfusion with 2-oxoisocaproate and 2-oxoisovalerate promoted increases in the level of citric cycle intermediates, a drop in both alanine and glutamate, and accumulation of branched-chain acylcarnitines. 2-Oxoisocaproate also caused a reduction of alanine released from the muscle. 5. Perfusion with leucine and valine did not change the concentration of citric acid cycle intermediates, but elevated glutamate and still more the concentration of alanine. 6. It is concluded that citric cycle intermediate level in the perfused resting muscle is modified by a) conditions which change the concentration of acetyl-CoA and thereby modify the rate of pyruvate carboxylation and decarboxylation of malate via malic enzyme b) conditions which change the concentration of pyruvate cause changes in alanine and cycle intermediates in the same direction via transamination reactions c) conditions which change the concentrations of 2-oxoacids which are converted to cycle intermediates via oxidation.  (+info)

(4/885) The role of an iron-sulfur cluster in an enzymatic methylation reaction. Methylation of CO dehydrogenase/acetyl-CoA synthase by the methylated corrinoid iron-sulfur protein.

This paper focuses on how a methyl group is transferred from a methyl-cobalt(III) species on one protein (the corrinoid iron-sulfur protein (CFeSP)) to a nickel iron-sulfur cluster on another protein (carbon monoxide dehydrogenase/acetyl-CoA synthase). This is an essential step in the Wood-Ljungdahl pathway of anaerobic CO and CO2 fixation. The results described here strongly indicate that transfer of methyl group to carbon monoxide dehydrogenase/acetyl-CoA synthase occurs by an SN2 pathway. They also provide convincing evidence that oxidative inactivation of Co(I) competes with methylation. Under the conditions of our anaerobic assay, Co(I) escapes from the catalytic cycle one in every 100 turnover cycles. Reductive activation of the CFeSP is required to regenerate Co(I) and recruit the protein back into the catalytic cycle. Our results strongly indicate that the [4Fe-4S] cluster of the CFeSP is required for reductive activation. They support the hypothesis that the [4Fe-4S] cluster of the CFeSP does not participate directly in the methyl transfer step but provides a conduit for electron flow from physiological reductants to the cobalt center.  (+info)

(5/885) The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog.

Serotonin N-acetyltransferase, a member of the GNAT acetyltransferase superfamily, is the penultimate enzyme in the conversion of serotonin to melatonin, the circadian neurohormone. Comparison of the structures of the substrate-free enzyme and the complex with a bisubstrate analog, coenzyme A-S-acetyltryptamine, demonstrates that acetyl coenzyme A (AcCoA) binding is accompanied by a large conformational change that in turn leads to the formation of the serotonin-binding site. The structure of the complex also provides insight into how the enzyme may facilitate acetyl transfer. A water-filled channel leading from the active site to the surface provides a pathway for proton removal following amine deprotonation. Furthermore, structural and mutagenesis results indicate an important role for Tyr-168 in catalysis.  (+info)

(6/885) Amino acid biosynthesis in the halophilic archaeon Haloarcula hispanica.

Biosynthesis of proteinogenic amino acids in the extremely halophilic archaeon Haloarcula hispanica was explored by using biosynthetically directed fractional 13C labeling with a mixture of 90% unlabeled and 10% uniformly 13C-labeled glycerol. The resulting 13C-labeling patterns in the amino acids were analyzed by two-dimensional 13C,1H correlation spectroscopy. The experimental data provided evidence for a split pathway for isoleucine biosynthesis, with 56% of the total Ile originating from threonine and pyruvate via the threonine pathway and 44% originating from pyruvate and acetyl coenzyme A via the pyruvate pathway. In addition, the diaminopimelate pathway involving diaminopimelate dehydrogenase was shown to lead to lysine biosynthesis and an analysis of the 13C-labeling pattern in tyrosine indicated novel biosynthetic pathways that have so far not been further characterized. For the 17 other proteinogenic amino acids, the data were consistent with data for commonly found biosynthetic pathways. A comparison of our data with the amino acid metabolisms of eucarya and bacteria supports the theory that pathways for synthesis of proteinogenic amino acids were established before ancient cells diverged into archaea, bacteria, and eucarya.  (+info)

(7/885) Melatonin, its precursors, and synthesizing enzyme activities in the human ovary.

The presence of melatonin (N-acetyl-5-methoxytryptamine) and its precursors, serotonin (5-hydroxytryptamine) and N-acetylserotonin, was demonstrated in extracts of human ovary using reverse-phase high-performance liquid chromatography coupled with fluorometric detection. In addition, activities of two melatonin-synthesizing enzymes, arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), were found in human ovary homogenates. The apparent Michaelis constants for the substrates of NAT and HIOMT in the human ovary were similar to those reported for the pineal glands of humans and other mammals. These findings strongly suggest that the human ovary, like the pineal gland, may synthesize melatonin from serotonin by the sequential action of NAT and HIOMT.  (+info)

(8/885) Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis.

Overexpression of the BltD gene in Bacillus subtilis causes acetylation of the polyamines spermidine and spermine. BltD is co-regulated with another gene, Blt, which encodes a multidrug export protein whose overexpression facilitates spermidine export [Woolridge, Vazquez-Laslop, Markham, Chevalier, Gerner and Neyfakh (1997) J. Biol. Chem. 272, 8864-8866]. Here we show that BltD acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. In the presence of saturating concentrations of acetyl CoA, BltD rapidly acetylates spermine at both the N1 and N12 positions. The Km (app) values for spermine, spermidine and N1-acetylspermine are +info)

*  Long-chain-fatty-acid-CoA ligase
Goodridge AG (November 1972). "Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate ... Numa S, Ringelmann E, Lynen F (December 1965). "[On inhibition of acetyl-CoA-carboxylase by fatty acid-coenzyme A compounds]". ... Majerus PW, Kilburn E (November 1969). "Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of ... Coenzyme A now enters the enzyme and another intermediate is formed which consists of AMP-long chain fatty acid-Coenzyme A. ( ...
*  Biotin-(acetyl-CoA-carboxylase) ligase
... acetyl-CoA carboxylase] synthetase, biotin-[acetyl coenzyme A carboxylase] synthetase, acetyl coenzyme A holocarboxylase ... Landman AD, Darkshinamurti K (March 1975). "Acetyl-Coenzyme A carboxylase. Role of the prosthetic group in enzyme ... acetyl-CoA:carbon-dioxide ligase (ADP-forming)] The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon- ... In enzymology, a biotin-[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15) is an enzyme that catalyzes the chemical reaction ATP + ...
*  Succinyl-CoA hydrolase
This enzyme participates in citrate cycle (tca cycle). Gergely J, Hele P, Ramakrishnan CV (1952). "Succinyl and acetyl coenzyme ... Other names in common use include succinyl-CoA acylase, succinyl coenzyme A hydrolase, and succinyl coenzyme A deacylase. ...
*  ACAT2
... acetyl-Coenzyme A acetyltransferase 2) gene Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase enzyme. ... acetyl-Coenzyme A acetyltransferase 2". Human ACAT2 genome location and ACAT2 gene details page in the UCSC Genome Browser. ... Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is ... Matsumoto K, Fujiwara Y, Nagai R, Yoshida M, Ueda S (Feb 2008). "Expression of two isozymes of acyl-coenzyme A: cholesterol ...
*  ACACB
Diaz FJ, Meary A, Arranz MJ, Ruaño G, Windemuth A, de Leon J (December 2009). "Acetyl-coenzyme A carboxylase alpha gene ... Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene. Acetyl-CoA ... Rosa G, Manco M, Vega N, Greco AV, Castagneto M, Vidal H, Mingrone G (November 2003). "Decreased muscle acetyl-coenzyme A ... acetyl-Coenzyme A carboxylase beta". Widmer J, Fassihi KS, Schlichter SC, Wheeler KS, Crute BE, King N, Nutile-McMenemy N, Noll ...
*  ACACA
... acetyl-Coenzyme A carboxylase alpha". Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ (April 1995). "Human acetyl- ... Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene. Acetyl-CoA ... Diaz FJ, Meary A, Arranz MJ, Ruaño G, Windemuth A, de Leon J (December 2009). "Acetyl-coenzyme A carboxylase alpha gene ... Yoon S, Lee MY, Park SW, Moon JS, Koh YK, Ahn YH, Park BW, Kim KS (September 2007). "Up-regulation of acetyl-CoA carboxylase ...
*  ACAA1
Acetyl-Coenzyme A acyltransferase 1 is an acetyl-CoA C-acyltransferase enzyme. This gene encodes an enzyme operative in the ... 3-Ketoacyl-CoA thiolase, peroxisomal also known as acetyl-Coenzyme A acyltransferase 1 is an enzyme that in humans is encoded ... acetyl-Coenzyme A acyltransferase 1". Bout A, Hoovers JM, Bakker E, Mannens MM, Geurts van Kessel A, Westerveld A, Tager JM, ... 1987). "Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2494-6. doi:10.1073/ ...
*  ACAT1
Acetyl-Coenzyme A acetyltransferase 1) gene. Acetyl-Coenzyme A acetyltransferase 1 is an acetyl-CoA C-acetyltransferase enzyme ... acetyl-Coenzyme A acetyltransferase 1". Kano, M; Fukao, T; Yamaguchi, S; Orii, T; Osumi, T; Hashimoto, T (30 December 1991). " ... Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by ... Ge, J; Zhai, W; Cheng, B; He, P; Qi, B; Lu, H; Zeng, Y; Chen, X (September 2013). "Insulin induces human acyl-coenzyme A: ...
*  ACAA2
Acetyl-Coenzyme A acyltransferase 2 is an acetyl-CoA C-acyltransferase enzyme. The ACAA2 gene encodes a 41.9 kDa protein that ... Cao W, Liu N, Tang S, Bao L, Shen L, Yuan H, Zhao X, Lu H (Jun 2008). "Acetyl-Coenzyme A acyltransferase 2 attenuates the ... 3-Ketoacyl-CoA thiolase, mitochondrial also known as acetyl-Coenzyme A acyltransferase 2 is an enzyme that in humans is encoded ... acetyl-Coenzyme A acyltransferase 2". Abe H, Ohtake A, Yamamoto S, Satoh Y, Takayanagi M, Amaya Y, Takiguchi M, Sakuraba H, ...
*  Carbon monoxide dehydrogenase
Tan X, Loke HK, Fitch S, Lindahl PA (2005). "The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates ... Hegg EL (October 2004). "Unraveling the structure and mechanism of acetyl-coenzyme A synthase". Acc. Chem. Res. 37 (10): 775-83 ... Lindahl PA (2009). "Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases". In Sigel, Helmut; Sigel ... CODH can form a monofunctional enzyme, as is the case in Rhodospirillum rubram, or can form a cluster with acetyl-CoA synthase ...
*  CO-methylating acetyl-CoA synthase
25 June 2004). "Acetyl-coenzyme A synthase: the case for a Nip0-based mechanism of catalysis". JBIC Journal of Biological ... Lindahl, Paul A. (25 June 2004). "Acetyl-coenzyme A synthase: the case for a Ni0-based mechanism of catalysis". Journal of ... Acetyl-CoA Synthase (ACS), not to be confused with Acetyl-CoA Synthetase or Acetate-CoA Ligase (ADP forming), is a Nickel ... Hegg, Eric L. (October 2004). "Unraveling the Structure and Mechanism of Acetyl-Coenzyme A Synthase". Accounts of Chemical ...
*  Methanothrix soehngenii
Jetten MS; Stams AJ; Zehnder AJ (October 1989). "Isolation and characterization of acetyl-coenzyme A synthetase from ...
*  Acetyl-CoA hydrolase
... acetyl-CoA acylase, acetyl coenzyme A hydrolase, acetyl coenzyme A deacylase, acetyl coenzyme A acylase, and acetyl-CoA thiol ... In enzymology, an acetyl-CoA hydrolase (EC 3.1.2.1) is an enzyme that catalyzes the chemical reaction acetyl-CoA + H2O ⇌ {\ ... The systematic name of this enzyme class is acetyl-CoA hydrolase. Other names in common use include acetyl-CoA deacylase, ... "Succinyl and acetyl coenzyme A deacylases". J. Biol. Chem. 198 (1): 323-334. PMID 12999747. Molecular and Cellular Biology ...
*  Polysialic-acid O-acetyltransferase
Higa HH, Varki A (1988). "Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme ... The systematic name of this enzyme class is acetyl-CoA:polysialic-acid O-acetyltransferase. Other names in common use include ... In enzymology, a polysialic-acid O-acetyltransferase (EC 2.3.1.136) is an enzyme that catalyzes the chemical reaction acetyl- ... responsible for the O-acetyl plus phenotype and for O-acetyl form variation". J. Biol. Chem. 263 (18): 8872-8. PMID 2897964. ...
*  Phosphoenolpyruvate carboxylase
At the end of glycolysis, PEP is converted to pyruvate, which is converted to acetyl-coenzyme-A (acetyl-CoA), which enters the ... Smith, Thomas E. (1970). "Escherichia coli phosphoenolpyruvate carboxylase: Competitive regulation by acetyl-coenzyme A and ... The main allosteric activators of PEP carboxylase are acetyl-CoA and fructose-1,6-bisphosphate (F-1,6-BP). Both molecules are ... It is also noteworthy that the negative effectors aspartate competes with the positive effector acetyl-CoA, suggesting that ...
*  10-hydroxytaxane O-acetyltransferase
This enzyme is also called acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase. Menhard B, Zenk MH (1999). "Purification ... and characterization of acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase from cell suspension cultures of Taxus ... In enzymology, a 10-hydroxytaxane O-acetyltransferase (EC 2.3.1.163) is an enzyme that catalyzes the chemical reaction acetyl- ... The systematic name of this enzyme class is acetyl-CoA:taxan-10beta-ol O-acetyltransferase. ...
*  Deacetylcephalosporin-C acetyltransferase
... acetyl coenzyme A:DAC acetyltransferase, acetyl-CoA:DAC acetyltransferase, CPC acetylhydrolase, acetyl-CoA:DAC O- ... S; Matsumoto, H; Matsuda, A; Sugiura, H; Komatsu, K; Ichikawa, S (1992). "Purification of acetyl coenzyme A: ... "Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium ... The systematic name of this enzyme class is acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase. Other names in common use ...
*  Wood-Ljungdahl pathway
It is also known as the reductive acetyl-coenzyme A (Acetyl-CoA) pathway. This pathway enables these organisms to use hydrogen ... Paul A. Lindahl "Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases" Met. Ions Life Sci. 2009, ... the formyl group is reduced to a methyl group and then combined with the carbon monoxide and Coenzyme A to produce acetyl-CoA. ... The former catalyzes the reduction of the CO2 and the latter combines the resulting CO with a methyl group to give acetyl-CoA. ...
*  Acetyl-CoA carboxylase
"Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery". Cell. Mol. Life Sci. 62 (16 ... Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to ... Lee CK, Cheong HK, Ryu KS, Lee JI, Lee W, Jeon YH, Cheong C (August 2008). "Biotinoyl domain of human acetyl-CoA carboxylase: ... The carboxyl group is transferred from biotin to acetyl CoA to form malonyl CoA in the second reaction, which is catalyzed by ...
*  Salutaridinol 7-O-acetyltransferase
doi:10.1016/S0040-4039(00)76696-2. Lenz R, Zenk MH (1995). "Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver ... In enzymology, a salutaridinol 7-O-acetyltransferase (EC 2.3.1.150) is an enzyme that catalyzes the chemical reaction acetyl- ... The systematic name of this enzyme class is acetyl-CoA:salutaridinol 7-O-acetyltransferase. This enzyme participates in ... the two substrates of this enzyme are acetyl-CoA and salutaridinol, whereas its two products are CoA and 7-O- ...
*  Malyl-CoA lyase
Tuboi S; Kikuchi G (1965). "Enzymic cleavage of malyl-Coenzyme A into acetyl-Coenzyme A and glyoxylic acid". Biochim. Biophys. ... acetyl-CoA + glyoxylate Hence, this enzyme has one substrate, (3S)-3-carboxy-3-hydroxypropanoyl-CoA, and two products, acetyl- ... The systematic name of this enzyme class is (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming). Other ... names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. This enzyme ...
*  Colchicine
The molecule of colchicine appears finally after addition of acetyl-coenzyme A to deacetylcolchicine. Since chromosome ...
*  Neuron
Acetylcholine is synthesized from choline and acetyl coenzyme A. GABAergic neurons-gamma aminobutyric acid. GABA is one of two ...
*  Herbicide
Acetyl coenzyme A carboxylase (ACCase) is part of the first step of lipid synthesis. Thus, ACCase inhibitors affect cell ... a family of herbicides that inhibit an enzyme called acetyl coenzyme A carboxylase. Ryegrass populations were large, and had ...
*  Sterol
They are amphipathic lipids synthesized from acetyl-coenzyme A via the HMG-CoA reductase pathway. The overall molecule is quite ...
*  Metabolism
... usually acetyl coenzyme A (acetyl-CoA), which releases some energy. Finally, the acetyl group on the CoA is oxidised to water ... These coenzymes are therefore continuously made, consumed and then recycled. One central coenzyme is adenosine triphosphate ( ... This reduced form of the coenzyme is then a substrate for any of the reductases in the cell that need to reduce their ... The electrons then flow through photosystem I and can then either be used to reduce the coenzyme NADP+, for use in the Calvin ...
Genetic Polymorphism Detection of the Exon 1 Region of Acetyl-CoA Carboxylase Alpha Gene in Iranian Mahabadi Goat Breed  Genetic Polymorphism Detection of the Exon 1 Region of Acetyl-CoA Carboxylase Alpha Gene in Iranian Mahabadi Goat Breed
Acetyl-coenzyme A carboxylase α (ACC-alpha) is considered as the key regulatory enzyme in fatty acid biosynthesis. ACC-alpha ... Associations of acetyl-coenzyme A carboxylase α, stearoyl-coenzyme A desaturase and lipoprotein lipase genes with dairy traits ... Acetyl-coenzyme A carboxylase α (ACC-alpha) is considered as the key regulatory enzyme in fatty acid biosynthesis. ACC-alpha ... Figure 1 Observed SSCP conformation patterns of the exon 1 of the acetyl-coenzyme A carboxylase α gene in Mahabadi goat ...
more infohttp://ijas.iaurasht.ac.ir/article_516657.html
Wheat acetyl-coenzyme A carboxylase: cDNA and protein structure | PNAS  Wheat acetyl-coenzyme A carboxylase: cDNA and protein structure | PNAS
Wheat acetyl-coenzyme A carboxylase: cDNA and protein structure. P Gornicki, J Podkowinski, L A Scappino, J DiMaio, E Ward, R ... Wheat acetyl-coenzyme A carboxylase: cDNA and protein structure. P Gornicki, J Podkowinski, L A Scappino, J DiMaio, E Ward, R ... Wheat acetyl-coenzyme A carboxylase: cDNA and protein structure. P Gornicki, J Podkowinski, L A Scappino, J DiMaio, E Ward, and ... cDNA fragments encoding part of wheat (Triticum aestivum) acetyl-CoA carboxylase (ACC; EC 6.4.1.2) were cloned by PCR using ...
more infohttps://www.pnas.org/content/91/15/6860?ijkey=266e982ed640a7a1f8791a6c0a348723c3efe88b&keytype2=tf_ipsecsha
Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174)  Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174)
Rabbit recombinant monoclonal Acetyl Coenzyme A Carboxylase antibody [EP687Y] validated for WB, IHC and tested in Human, Mouse ... Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y]. See all Acetyl Coenzyme A Carboxylase primary antibodies. ... Anti-Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174) at 1/2000 dilution + A431 cell lysate at 10 µg. Secondary. Goat ... Acetyl Coenzyme A Carboxylase is highly expressed in lipogenic tissues such as liver, adipose, and lactating mammary gland, and ...
more infohttp://www.abcam.com/acetyl-coenzyme-a-carboxylase-antibody-ep687y-ab45174.html
Acetyl-coenzyme A - definition of Acetyl-coenzyme A by The Free Dictionary  Acetyl-coenzyme A - definition of Acetyl-coenzyme A by The Free Dictionary
Acetyl-coenzyme A pronunciation, Acetyl-coenzyme A translation, English dictionary definition of Acetyl-coenzyme A. n. See ... Define Acetyl-coenzyme A. Acetyl-coenzyme A synonyms, ... Acetyl-coenzyme A - definition of Acetyl-coenzyme A by The Free ... redirected from Acetyl-coenzyme A). Also found in: Medical. a·ce·tyl-Co·A. (ə-sēt′l-kō′ā′, ăs′ĭ-tl-). n.. See acetyl coenzyme A ... These acids are made from acetyl-coenzyme A (acetyl-CoA), which is also the starting material for biosynthesis of waxes, ...
more infohttp://www.thefreedictionary.com/Acetyl-coenzyme+A
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (A6QHN4) | InterPro | EMBL-EBI  Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (A6QHN4) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
more infohttp://www.ebi.ac.uk/interpro/protein/A6QHN4
Acetyl Coenzyme A  Acetyl Coenzyme A
... This coenzyme plays a huge role in intermediary metabolism, in which cells synthesize, break down or use ... Selected acetyl coenzyme A links: © 1997-2006 Healthboard.com. Healthboard.com is a purely informational website, and should ...
more infohttp://healthboard.com/Encyclopedia/Biotech/term/acetyl_coenzyme_a.html
Anti-Acetyl Coenzyme A carboxylase alpha antibody (ab72046) Protocols  Anti-Acetyl Coenzyme A carboxylase alpha antibody (ab72046) Protocols
Abcam provides specific protocols for Anti-Acetyl Coenzyme A carboxylase alpha antibody (ab72046) : Western blot protocols, ...
more infohttp://www.abcam.com/acetyl-coenzyme-a-carboxylase-alpha-antibody-ab72046-protocols.html
Acetyl Coenzyme A Carboxylase Beta Antibodies: Novus Biologicals  Acetyl Coenzyme A Carboxylase Beta Antibodies: Novus Biologicals
Browse our Acetyl Coenzyme A Carboxylase Beta Antibody catalog backed by our Guarantee+. ... Acetyl Coenzyme A Carboxylase Beta Antibodies available through Novus Biologicals. ... Acetyl Coenzyme A Carboxylase Beta Antibodies. We offer Acetyl Coenzyme A Carboxylase Beta Antibodies for use in common ... Alternate Names for Acetyl Coenzyme A Carboxylase Beta Antibodies. anti-Acetyl Coenzyme A Carboxylase Beta antibody, anti-ACACB ...
more infohttps://www.novusbio.com/primary-antibodies/acetyl-coenzyme-a-carboxylase-beta?related_diseases=Kidney%20Diseases
Acetyl Coenzyme A Carboxylase Beta Antibodies: Novus Biologicals  Acetyl Coenzyme A Carboxylase Beta Antibodies: Novus Biologicals
Browse our Acetyl Coenzyme A Carboxylase Beta Antibodies all backed by our Guarantee+. ... Acetyl Coenzyme A Carboxylase Beta Antibodies available through Novus Biologicals. ... Acetyl Coenzyme A Carboxylase Beta Antibodies. We offer Acetyl Coenzyme A Carboxylase Beta Antibodies for use in common ... Alternate Names for Acetyl Coenzyme A Carboxylase Beta Antibodies. anti-Acetyl Coenzyme A Carboxylase Beta antibody, anti-ACACB ...
more infohttps://www.novusbio.com/primary-antibodies/acetyl-coenzyme-a-carboxylase-beta?related_pathways=Cell%20Proliferation
A Multisubunit Acetyl Coenzyme A Carboxylase from Soybean | Plant Physiology  A Multisubunit Acetyl Coenzyme A Carboxylase from Soybean | Plant Physiology
A Multisubunit Acetyl Coenzyme A Carboxylase from Soybean Message Subject (Your Name) has sent you a message from Plant ... 1994) Wheat acetyl-coenzyme A carboxylase: cDNA and protein structure. Proc Natl Acad Sci USA 91:6860-6864. ... A Multisubunit Acetyl Coenzyme A Carboxylase from Soybean. Sergei Reverdatto, Vadim Beilinson, Niels C. Nielsen ... 1974) Acetyl coenzyme A carboxylase system of Escherichia coli: purification and properties of the biotin carboxylase, carboxyl ...
more infohttp://www.plantphysiol.org/content/119/3/961
acs - Acetyl-coenzyme A synthetase - Escherichia coli (strain K12) - acs gene & protein  acs - Acetyl-coenzyme A synthetase - Escherichia coli (strain K12) - acs gene & protein
In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the ... In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. ... Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and ... "Regulation of acetyl coenzyme A synthetase in Escherichia coli.". Kumari S., Beatty C.M., Browning D.F., Busby S.J., Simel E.J. ...
more infohttp://www.uniprot.org/uniprot/P27550
RCSB PDB - Protein Feature View 









 - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - P0ABD5 (ACCA...  RCSB PDB - Protein Feature View - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - P0ABD5 (ACCA...
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin ... Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two ... on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl- ...
more infohttp://www.rcsb.org/pdb/protein/P0ABD5
accD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta - Bacillus sp. JS - accD gene & protein  accD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta - Bacillus sp. JS - accD gene & protein
... group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. ... Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on ... Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase ... Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation. ,p>Information which has been generated by ...
more infohttps://www.uniprot.org/uniprot/I0F7J2
Acetyl Coenzyme A - Molecule of the Month May 2007 - HTML-only version  Acetyl Coenzyme A - Molecule of the Month May 2007 - HTML-only version
Coenzyme A. The 'business end', the -SH group where the acetyl group attaches, is shown in red. The fragment from ADP is shown ... Acetyl Coenzyme A. In the 1930's-early 1940's, four German-born biochemists, Fritz Lipmann, Hans Krebs, Feodor Lynen and Konrad ... In the Citric Acid Cycle, these C2 fragments are reacted with CoA, to form acetyl-CoA. The acetyl residue is then transported ... This means that the acetyl group can be easily transferred to other molecules, and so acetyl-CoA is used as a universal ...
more infohttp://www.chm.bris.ac.uk/motm/acetylcoa/acoah.htm
Acetyl coenzyme A | Article about acetyl coenzyme A by The Free Dictionary  Acetyl coenzyme A | Article about acetyl coenzyme A by The Free Dictionary
Find out information about acetyl coenzyme A. C23H39O17N7P3S A coenzyme, derived principally from the metabolism of glucose and ... fatty acids, that takes part in many biological acetylation reactions;... Explanation of acetyl coenzyme A ... acetyl coenzyme A. Also found in: Dictionary, Medical, Wikipedia. acetyl coenzyme A. [ə‚sed·əl ‚kō′en‚zīm ′ā] (biochemistry) C ... Acetyl coenzyme A , Article about acetyl coenzyme A by The Free Dictionary https://encyclopedia2.thefreedictionary.com/acetyl+ ...
more infohttps://encyclopedia2.thefreedictionary.com/acetyl+coenzyme+A
Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation | Biochemical Journal  Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation | Biochemical Journal
Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation. Julia C. Mackall, M. Daniel ... Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation ... Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation ... Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation ...
more infohttp://www.biochemj.org/content/162/3/635
Anti-S-Acetyl-Coenzyme A Synthetase Antibody | Rabbit anti-Yeast  | LSBio  Anti-S-Acetyl-Coenzyme A Synthetase Antibody | Rabbit anti-Yeast | LSBio
S-Acetyl-Coenzyme A Synthetase antibody LS-C147274 is an unconjugated rabbit polyclonal antibody to yeast S-Acetyl-Coenzyme A ... S-Acetyl-Coenzyme A Synthetase antibody LS-C147274 is an unconjugated rabbit polyclonal antibody to yeast S-Acetyl-Coenzyme A ... Yeast S-Acetyl-Coenzyme A Synthetase. The reagents were evaluated for potency, purity and specificity using most or all of the ... S‑AcetylCoenzyme A Synthetase Antibody LS‑C147274 S‑AcetylCoenzyme A Synthetase Antibody LS‑C147274 ...
more infohttps://www.lsbio.com/antibodies/s-acetyl-coenzyme-a-synthetase-antibody-elisa-if-immunofluorescence-ihc-wb-western-ls-c147274/152463
Acetyl-coenzyme A synthetase, cytoplasmic | definition of acetyl-coenzyme A synthetase, cytoplasmic by Medical dictionary  Acetyl-coenzyme A synthetase, cytoplasmic | definition of acetyl-coenzyme A synthetase, cytoplasmic by Medical dictionary
What is acetyl-coenzyme A synthetase, cytoplasmic? Meaning of acetyl-coenzyme A synthetase, cytoplasmic medical term. What does ... Looking for online definition of acetyl-coenzyme A synthetase, cytoplasmic in the Medical Dictionary? acetyl-coenzyme A ... Acetyl-coenzyme A synthetase, cytoplasmic , definition of acetyl-coenzyme A synthetase, cytoplasmic by Medical dictionary https ... redirected from acetyl-coenzyme A synthetase, cytoplasmic) ACSS2. A gene on chromosome 20q11.22, which encodes a cytosolic ...
more infohttp://medical-dictionary.thefreedictionary.com/acetyl-coenzyme+A+synthetase%2C+cytoplasmic
  • Synthesis of Spiro[chroman-2-4'-piperidin]-4-one Derivatives as Acetyl-CoA Carboxylase Inhibitors" Bioorganic & Medicinal Chemistry Letters 19:949-953 (2009). (patents.com)
  • Huang T, Sun J, Wang Q, Gao J, Liu Y (2015) Synthesis, biological evaluation and molecular docking studies of piperidinylpiperidines and spirochromanones possessing quinoline moieties as acetyl-CoA carboxylase inhibitors. (springer.com)
  • This coenzyme plays a huge role in intermediary metabolism, in which cells synthesize, break down or use nutrient molecules for energy production, growth, etc. (healthboard.com)
  • The A stood for acetyl, since one of CoA's main jobs is to transfer two-carbon units in the form of acetyl between various biological molecules. (bris.ac.uk)
  • This means that the acetyl group can be easily transferred to other molecules, and so acetyl-CoA is used as a universal intermediate which provides the C 2 fragment for numerous biochemical syntheses. (bris.ac.uk)
  • The acetyl residue is then transported via the blood to other molecules residing in cells all over the body, where it is released and, in the presence of O 2 , oxidised to carbon dioxide. (bris.ac.uk)
  • We believe that supplying the Krebs Cycle with enough substrates and increasing the Acetyl Coenzyme A (providing sufficient energy to the cell to sustain life) will be able to maintain the cell viable for prolonged periods of time. (thefreedictionary.com)
  • An important metabolic agent that transfers acetyl groups to the KREBS CYCLE and to various synthesizing pathways. (thefreedictionary.com)
  • The most important acid is acetic acid, and when it is joined to CoA, the resulting compound is known as acetyl-CoA. (bris.ac.uk)
  • In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (uniprot.org)
  • Coenzyme A. The 'business end', the -SH group where the acetyl group attaches, is shown in red. (bris.ac.uk)
  • The expression levels of 3-hydroxyacyl-CoA dehydrogenase type-2 (HCDH), acetyl-Coenzyme A acetyltransferase 2 (ACAT) and elongation factor Tu were down-regulated, and alpha-enolase and creatine kinase were up-regulated in the livers of ketotic cows. (thefreedictionary.com)
  • The second step results in the transfer of the carboxyl from carboxybiotin to acetyl CoA to form malonyl CoA. (plantphysiol.org)
  • Acetyl coenzyme A-dependent N-acetyltransferase and O-acetyltransferase activities were examined in liver cytosols derived from homozygous rapid acetylator C57BL/6J and A.B6 congenic inbred mouse strains, from homozygous slow acetylator A/J and B6.A congenic inbred mouse strains, and from the (C57BL/6J x A/J)F1 heterozygous acetylator hybrid mouse strain. (aspetjournals.org)
  • The process leading to the rise of acetyl-CoA carboxylase activity in rat mammary tissue after the onset of lactation was investigated. (biochemj.org)