A potent eye, throat, and skin irritant. One of its uses is as a riot control agent.
A family of gram-negative bacteria in the order Rhodocyclales, class BETAPROTEOBACTERIA. It includes many genera previously assigned to the family PSEUDOMONADACEAE.
Agencies of the FEDERAL GOVERNMENT of the United States.
A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
These enzymes catalyze the elimination of ammonia from amidines with the formation of a double bond. EC 4.3.2.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Topical antiseptic used mainly in wound dressings.
The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.
Three individuals derived from three FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.
An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.
The reactions, changes in structure and composition, the properties of the reactions of carbon compounds, and the associated energy changes.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
A plant genus of the family EUPHORBIACEAE. Members contain fredelin type TRITERPENES, mallorepine (a cyano-pyridone), and hydrolyzable TANNINS.
Addition of hydrogen to a compound, especially to an unsaturated fat or fatty acid. (From Stedman, 26th ed)
A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A country spanning from central Asia to the Pacific Ocean.
A plant family of the order Linales, subclass Rosidae, class Magnoliopsida best known for the coca plant.

Arachidonic acid, but not its metabolites, is essential for FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes. (1/833)

Since arachidonic acid (AA) production by phospholipase A2 (PLA2) is essential for the Fcgamma receptor (FcgammaR)-mediated respiratory burst and phagocytosis of opsonized erythrocytes by monocytes and macrophages, we focused in this study on the role of AA and its metabolites in the FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes. The results revealed that the PLA2 inhibitors, but not inhibitors of cyclo-oxygenase and lipoxygenase, markedly suppressed the FcgammaR-mediated killing process. The production of O-2 by monocytes upon FcgammaR cross-linking was inhibited by 4-bromophenacyl bromide in a dose-dependent fashion, indicating that inhibition of PLA2 activity impairs the oxygen-dependent bactericidal mechanisms of monocytes, which could be partially restored by addition of exogenous AA and docosahexaenoic acid, but not myristic acid. These polyunsaturated fatty acids, but not myristic acid, stimulated the intracellular killing of S. aureus by monocytes, although not as effectively as FcgammaR cross-linking. Furthermore, FcgammaR cross-linking stimulated the release of AA from monocytes. Studies with selective inhibitors revealed that the FcgammaR-mediated activation of PLA2 is dependent on Ca2+ and tyrosine kinase activity. Together these results indicate a key role for PLA2/AA, but not its major metabolites, in mediating the FcgammaR-stimulated intracellular killing of S. aureus by monocytes.  (+info)

Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. (2/833)

In several neuronal cell systems, fibroblast-derived growth factor (FGF) and nerve growth factor (NGF) act as neurogenic agents, whereas epidermal growth factor (EGF) acts as a mitogen. The mechanisms responsible for these different cellular fates are unclear. We report here that although FGF, NGF, and EGF all activate mitogen-activated protein (MAP) kinase (extracellular signal-related kinase [ERK]) in rat hippocampal (H19-7) and pheochromocytoma (PC12) cells, the activation of ERK by the neurogenic agents FGF and NGF is dependent upon protein kinase Cdelta (PKCdelta), whereas ERK activation in response to the mitogenic EGF is independent of PKCdelta. Antisense PKCdelta oligonucleotides or the PKCdelta-specific inhibitor rottlerin inhibited FGF- and NGF-induced, but not EGF-induced, ERK activation. In contrast, EGF-induced ERK activation was inhibited by the phosphatidylinositol-3-kinase inhibitor wortmannin, which had no effect upon FGF-induced ERK activation. Rottlerin also inhibited the activation of MAP kinase kinase (MEK) in response to activated Raf, but had no effect upon c-Raf activity or ERK activation by activated MEK. These results indicate that PKCdelta functions either downstream from or in parallel with c-Raf, but upstream of MEK. Inhibition of PKCdelta also blocked neurite outgrowth induced by FGF and NGF in PC12 cells and by activated Raf in H19-7 cells, indicating a role for PKCdelta in the neurogenic effects of FGF, NGF, and Raf. Interestingly, the PKCdelta requirement is apparently cell type specific, since FGF-induced ERK activation was independent of PKCdelta in NIH 3T3 murine fibroblasts, in which FGF is a mitogen. These data demonstrate that PKCdelta contributes to growth factor specificity and response in neuronal cells and may also promote cell-type-specific differences in growth factor signaling.  (+info)

Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. (3/833)

UV-induced signal transduction may be involved in tumor promotion and induction of apoptosis. The role of protein kinase C (PKC) in UVB-induced signal transduction is not well understood. This study showed that UVB markedly induced translocation of membrane-associated PKCepsilon and PKCdelta, but not PKCalpha, from cytosol to membrane. Dominant negative mutant (DNM) PKCepsilon or PKCdelta inhibited UVB-induced translocation of PKCepsilon and PKCdelta, respectively. UVB-induced activation of extracellular signal-regulated protein kinases (Erks) and c-Jun NH2-terminal kinases (JNKs) was strongly inhibited by DNM PKCepsilon and PKCdelta, whereas the DNM of PKCalpha was less effective on the UVB-induced phosphorylation of Erks and JNKs. Among the PKC inhibitors used only rottlerin, a selective inhibitor of PKCdelta, markedly inhibited the UVB-induced activation of Erks and JNKs, but not p38 kinases. Safingol, a selective inhibitor for PKCalpha, did not show any inhibitory effect on UVB-induced mitogen-activated protein kinase activation. GF109203X is a stronger inhibitor of classical PKC than novel PKC. Lower concentrations of GF109203X (<10 microM) had no effect on UVB-induced activation of Erks or JNKs. However, at higher concentrations (over 20 microM), GF109203X inhibited UVB-induced activation of JNKs, Erks, and even p38 kinases. Meanwhile, rottlerin and GF109203X markedly inhibited UVB-induced apoptosis of JB6 cells, whereas safingol had little inhibitory effect. DNM-Erk2 cells and PD98059, a selective inhibitor for mitogen-activated protein kinase/extracellular signal-regulated kinase 1 that directly activates Erks, inhibited UVB-induced apoptosis. DNM-JNK1 cells also blocked UVB-induced apoptosis, whereas SB202190, a specific inhibitor for p38 kinases, did not produce the inhibitory effect. These data demonstrate that PKCdelta and PKCepsilon, but not PKCalpha, mediate UVB-induced signal transduction and apoptosis in JB6 cells through activation of Erks and JNKs.  (+info)

Odor response properties of rat olfactory receptor neurons. (4/833)

Molecular biology studies of olfaction have identified a multigene family of molecular receptors that are likely to be involved in odor transduction mechanisms. However, because previous functional data on peripheral coding were mainly collected from inferior vertebrates, it has been difficult to document the degree of specificity of odor interaction mechanisms. As a matter of fact, studies of the functional expression of olfactory receptors have not demonstrated the low or high specificity of olfactory receptors. In this study, the selectivity of olfactory receptor neurons was investigated in the rat at the cellular level under physiological conditions by unitary extracellular recordings. Individual olfactory receptor neurons were broadly responsive to qualitatively distinct odor compounds. We conclude that peripheral coding is based on activated arrays of olfactory receptor cells with overlapping tuning profiles.  (+info)

Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. (5/833)

We have previously shown that parotid C5 salivary acinar cells undergo apoptosis in response to etoposide treatment as indicated by alterations in cell morphology, caspase-3 activation, DNA fragmentation, sustained activation of c-Jun N-terminal kinase, and inactivation of extracellular regulated kinases 1 and 2. Here we report that apoptosis results in the caspase-dependent cleavage of protein kinase C-delta (PKCdelta) to a 40-kDa fragment, the appearance of which correlates with a 9-fold increase in PKCdelta activity. To understand the function of activated PKCdelta in apoptosis, we have used the PKCdelta-specific inhibitor, rottlerin. Pretreatment of parotid C5 cells with rottlerin prior to the addition of etoposide blocks the appearance of the apoptotic morphology, the sustained activation of c-Jun N-terminal kinase, and inactivation of extracellular regulated kinases 1 and 2. Inhibition of PKCdelta also partially inhibits caspase-3 activation and DNA fragmentation. Immunoblot analysis shows that the PKCdelta cleavage product does not accumulate in parotid C5 cells treated with rottlerin and etoposide together, suggesting that the catalytic activity of PKCdelta may be required for cleavage. PKCalpha and PKCbeta1 activities also increase during etoposide-induced apoptosis. Inhibition of these two isoforms with Go6976 slightly suppresses the apoptotic morphology, caspase-3 activation, and DNA fragmentation, but has no effect on the sustained activation of c-Jun N-terminal kinase or inactivation of extracellular regulated kinase 1 and 2. These data demonstrate that activation of PKCdelta is an integral and essential part of the apoptotic program in parotid C5 cells and that specific activated isoforms of PKC may have distinct functions in cell death.  (+info)

Dual efficacy of lamivudine treatment in human immunodeficiency virus/hepatitis B virus-coinfected persons in a randomized, controlled study (CAESAR). The CAESAR Coordinating Committee. (6/833)

The efficacy and safety of lamivudine in persons coinfected with human immunodeficiency virus (HIV) type 1 and hepatitis B virus (HBV) were examined in the CAESAR study, a randomized placebo-controlled trial assessing the addition of lamivudine (150 mg 2x/day) or lamivudine (150 mg 2x/day) plus loviride (100 mg 3x/day) to zidovudine-containing background antiretroviral treatment. Baseline hepatitis B surface antigen (HBsAg) results were available for 1790 study subjects, of whom 122 (6.8%) tested positive. Retrospective analyses for serial HBV DNA, HBsAg, and hepatitis B e antigen (HBeAg) were performed on stored sera from 118 HBsAg-positive subjects. HBV DNA and HBeAg were present in 83% and 63%, respectively. At weeks 12 and 52, median log10 HBV DNA change was -2.0 and -2.7, respectively, in the lamivudine arms, compared with no reduction among placebo recipients (P<.001). A trend to lower alanine transferase level, and delayed progression of HIV-1 disease (relative hazard, 0.26; 95% confidence interval, 0.08-0.80) were also seen in the lamivudine arms, compared with the placebo group.  (+info)

Apocynin improves diaphragmatic function after endotoxin administration. (7/833)

Free radicals are known to play an important role in modulating the development of respiratory muscle dysfunction during sepsis. Moreover, neutrophil numbers increase in the diaphragm after endotoxin administration. Whether or not superoxide derived from infiltrating white blood cells contributes to muscle dysfunction during sepsis is, however, unknown. The purpose of the present study was to examine the effect of apocynin, an inhibitor of the superoxide-generating neutrophil NADPH complex, on endotoxin-induced diaphragmatic dysfunction. We studied groups of rats given saline, endotoxin, apocynin, or both endotoxin and apocynin. Animals were killed 18 h after injection, a portion of the diaphragm was used to assess force generation, and the remaining diaphragm was used for determination of 4-hydroxynonenal (a marker of lipid peroxidation) and nitrotyrosine levels (a marker of free radical-mediated protein modification). We found that endotoxin reduced diaphragm force generation and that apocynin partially prevented this decrease [e.g., force in response to 20 Hz was 23 +/- 1 (SE), 12 +/- 2, 23 +/- 1, and 19 +/- 1 N/cm(2), respectively, for saline, endotoxin, apocynin, and endotoxin/apocynin groups; P < 0.001]. Apocynin also prevented endotoxin-mediated increases in diaphragm 4-hydroxynonenal and nitrotyrosine levels (P < 0.01). These data suggest that neutrophil-derived free radicals contribute to diaphragmatic dysfunction during sepsis.  (+info)

Theoretical elucidation of activity differences of five phenolic antioxidants. (8/833)

AIM: To verify the effectiveness of structure-activity relationship (SAR) and theoretical calculation methods for antioxidants. METHODS: Preliminary elucidation on the differences of activities of 5 antioxidants was performed by SAR. Then semiempirical quantum chemistry method AM1 was employed to calculate the delta HOF value, the difference between the heat of formation of antioxidant and its free radical, which was used as a theoretical parameter to elucidate the differences of activities of the antioxidants thoroughly. RESULTS: delta HOF values of antioxidants were obtained as follows: ferulic acid, 150.58 kJ.mol-1; anion of ferulic acid, 122.64 kJ.mol-1; modified ferulic acid, 137.70 kJ.mol-1; anion of modified ferulic acid, 118.99 kJ.mol-1; salvianic acid, 134.17 kJ.mol-1; rutin, 137.83 kJ.mol-1, L-EGCG, 124.39 kJ.mol-1; paeonol, 176.79 kJ.mol-1. The differences of the antioxidant activities were elucidated, and how to further enhance the antioxidant activity was investigated as well. CONCLUSION: The SAR and calculation methods are rather effective to elucidate the differences of antioxidant activities, and present some new clues for structural modification of antioxidants to increase their activities.  (+info)

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TY - JOUR. T1 - Protective effects of apocynin on cisplatin-induced ototoxicity in an auditory cell line and in zebrafish. AU - Choi, June. AU - Im, Gi Jung. AU - Chang, Jiwon. AU - Chae, Sung Won. AU - Lee, Seung Hoon. AU - Kwon, Soon Young. AU - Chung, Ah Young. AU - Park, Hae Chul. AU - Jung, Hak Hyun. PY - 2013/2. Y1 - 2013/2. N2 - Cisplatin is a very effective anticancer drug and generates reactive oxygen species (ROS) such as superoxide anions that can deplete antioxidant protective molecules in the cochlea. These processes result in the death of cochlear hair cells by induction of apoptosis. Apocynin, which is used as a specific nicotinamide adenine dinucleotide phosphate oxidase inhibitor, has a preventive effect for intracellular ROS generation. In this study, the effect of apocynin was investigated in a cochlear organ of Corti-derived cell line, HEI-OC1 cells, and in transgenic zebrafish (Brn3C: EGFP). To investigate the protective effects of apocynin, HEI-OC1 cells were treated with ...
Detail záznamu - Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension - Detail záznamu - Knihovna Akademie věd České republiky
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a Full Text option. The original article is trackable via the References option ...
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TY - JOUR. T1 - Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCδ-independent fashion. AU - Zhao, Hongyu. AU - Tian, Wei. AU - Cohen, David M.. PY - 2002. Y1 - 2002. N2 - Novel protein kinase C (PKC) isoforms PKCδ and PKCε have recently been implicated in signaling by hypertonic stress. We investigated the role of the putative PKCδ inhibitor rottlerin on tonicity-dependent gene regulation. In the renal medullary mIMCD3 cell line, rottlerin blocked tonicity-dependent transcription of a tonicity enhancer (TonE)-driven luciferase reporter gene, as well as tonicity-dependent transcription of the physiological tonicity effector gene aldose reductase, but not urea-dependent transcription. Consistent with these data, rottlerin inhibited tonicity-dependent expression of TonE binding protein (TonEBP) at the mRNA and protein levels. Another inhibitor of both novel and conventional PKC isoforms, GF-109203X, suppressed TonEBP-dependent transcription but failed to influence ...
Compared to the currently available therapeutic drugs for peripheral vascular diseases, agents that are selective for relaxing pulmonary circulation are scarce. The present study was undertaken, using isometric tension change measurement and whole-cell patch-clamp electrophysiology methods, to evaluate the vascular relaxation effect and the underlying mechanisms involved of two naturally found alkaloids: paeonol (2-hydroxy-4-methoxy-acetophenone), acetovanillone (4-hydroxy-3-methoxy-acetophenone) and the non-substituted analogue acetophenone on pulmonary artery of Sprague-Dawley rats. Cumulative administration (3 μM-1 mM) of acetophenone analogues resulted in a concentration-dependent relaxation of phenylephrine (1 μM) pre-contracted pulmonary artery. A relative order of inhibitory potency, estimated by comparing the concentration at which a 50% relaxation of phenylephrine-induced contraction observed was: acetovanillone , paeonol , acetophenone. Endothelial denudation and inhibition of nitric ...
Hydroxyacetophenone (HAP, CAS 99-93-4) Market by Product (2-Hydroxyacetophenone, 4-Hydroxyacetophenone), by Application (Pharmaceuticals, Chemical Intermediates, Cosmetics) and by Region, Trend, Forecast, Competitive Analysis, and Growth Opportunity 2019-2024 - Radiant Insights
Cheung S-Y, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S (2018) Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. Eur J Med Chem 156:815-830. ...
E.R.T., Tiekink, (2015) A crystallographic and computational study of 1-(arylamino)-1,2,3-triazole-4-carbohydrazides. CrystEngComm, 17. pp. 2255-2266. E.R.T., Tiekink, (2015) Bipodal benzoylthiocarbamic acid esters: Crystal and molecular structures of R = Et (a polymorph), and of a binuclear Cu(I) complex, R = iPr. Zeitschrift Fur Kristallographie, 230. pp. 397-405. E.R.T., Tiekink, (2015) Conformational preferences for isomeric N,N-bis(pyridin-n-ylmethyl)ethanedithio-diamides, n = 2, 3 and 4: A combined crystallographic and DFT study. Zeitschrift Fur Kristallographie-Crystalline Materials, 230. pp. 531-541. E.R.T., Tiekink, (2015) Conformational study of some 4-substituted 2-(phenylselanyl)-2-(ethylsulfonyl)- acetophenones. Journal of Molecular Structure, 1084. pp. 190-199. E.R.T., Tiekink, (2015) Crystal structure of catena-poly[(u2-chlorido)-bis(N-ethyl,N-hydroxyethylcarbamo-dithioato-u2S,S)bismuth(III) monohydrate], C10H22BiClN2O3S4. Zeitschrift Fur Kristallographie-New Crystal ...
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Lamani, M. and Prabhu, K. R. (2012), NIS-Catalyzed Reactions: Amidation of Acetophenones and Oxidative Amination of Propiophenones. Chem. Eur. J., 18: 14638-14642. doi: 10.1002/chem.201202703 ...
Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. These findings are likely to be intertwined in a mechanistic pathway to kidney damage and this thesis investigated their roles in the development of diabetic nephropathy. In vivo, diabetes-induced oxidative stress stimulates renal tubular Na+ transport and in vitro, proximal tubular cells from diabetic rats display increased transport-dependent oxygen consumption, demonstrating mechanisms contributing to decreased kidney oxygenation. In control animals, endogenous adenosine reduces vascular resistance of the efferent arteriole via adenosine A2-receptors resulting in reduced filtration fraction. However, in ...
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2,4-dihydroxyacetophenone (10.64 g, 0.07 mol) and potassium hydroxide (10.58 g, 0.189 mol) were dissolved in dry acetone (100 ml) in a three-neck flask. Then ethyl bromoacetate (28.06 g, 0.168 mol) was dropwise added at room temperature and vigorously stirred for 3 h. The progress of the reaction was monitored by TCL (Si gel, developing solvent V (acetone) /V (petroleum ether) = 1:2). After suction filtration and distillation to remove the solvent, a white solid was obtained, 19.76 g, yield 87.1%. This solid was dissolved in acetone (30 ml) and 20% aq. NaOH (50 ml) was added. The reaction mixture was stirred at 323 K for 1.5 h. After acidifying the misxture with dilute hydrochloric acid to pH=3, followed by suction filtrationand washing the residue with water, the target product was prepared. After recrystallization from ethanol, crystalline colorless needles were obtained.. ...
Human being monoclonal antibodies (HMAbs) with neutralizing capabilities constitute potential immune-based remedies or prophylaxis against hepatitis C disease (HCV). in BSF 208075 support of three HMAbs (HC-1AM, HC84.24, and AR4A) neutralized all 16 HCVcc recombinants. Furthermore, the IC50-ideals for confirmed HMAb assorted using the HCVcc stress significantly, which supports the usage of a varied disease panel. In assistance analyses, HMAbs HC84.24, AR3A, and, hC84 especially.26, demonstrated synergistic results towards a lot of the HCVccs when combined individually with AR4A. Through a neutralization evaluation of 10 relevant HMAbs against 16 JFH1-centered Core-NS2 recombinants from genotypes 1a medically, 1b, 2a, 2b, 2c, and 3a, we identified at least 3 HMAbs with wide and powerful neutralization potential. The neutralization synergism acquired when pooling the strongest HMAbs could possess significant implications for developing novel ways of deal with and control HCV. transfection and ...
This article describes the International Genetically Engineered Machine competition (IGEM 2010) entry of the authors.They describe transefering the signaling pathway of A. tumefaciens into E. coli cells and linking it with a luminescent readout using firefly luciferase.
Examples of effect: Lead to damage to heath, cause irritation to eyes, skin or respiratory organs. Are fatal in larger quantities. Safety: As previously stated, in the event of skin irritation or contact with eyes, rinse with water or a suitable medium. ...
Examples of effect: Lead to damage to heath, cause irritation to eyes, skin or respiratory organs. Are fatal in larger quantities. Safety: As previously stated, in the event of skin irritation or contact with eyes, rinse with water or a suitable medium. ...
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Oxidative stress is a major mediator of cellular injury following ischaemic stroke and reactive oxygen species, like superoxide, have multiple deleterious effects on the components of the neurovascular unit. It is well established that NADPH oxidase is the principal source of superoxide in acute ischaemic stroke and is therefore a target for potential neuroprotective strategies (Moskowitz et al, 2010). Consequently, the second aim of this thesis was to evaluate the potential neuroprotective effect of NADPH oxidase inhibition with low and high dose apocynin following permanent or transient ischaemia. Rats were administered apocynin at a dose of 5mg/kg or 30mg/kg or vehicle, at 5 minutes post-MCAO. Apocynin treatment had no significant effect on infarct volume or functional outcome at 24 hours following permanent MCAO in WKY rats. However, both low and high dose apocynin treatment significantly reduced infarct volume at 72 hours post-MCAO by 60% following 1 hour of ischaemia in Sprague-Dawley ...
Our β-Nicotinamide-Adenine Dinucleotide Phosphate, Monopotassium Salt (β-NADP-K) is applicable for making Creatine Kinase N-acetylcysteine (CK-NAC), Creatine Kinase Myoglobin (CK-MB), and Glucose reagents ...
In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen - Schmidt condensation by trituration method. Appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of sodium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR, H-NMR spectral data. All the compounds were tested for their antibacterial activities by the cup plate method.
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TY - CONF. T1 - HYPERGLYCAEMIA ALTERS NOX4 NADPH OXIDASE-MEDIATED ENDOTHELIAL CELL REGULATION IN VITRO. AU - Gill, Eleanor. AU - Edgar, Kevin. AU - Wilson, Adam J. AU - Patterson, Ellen. AU - Grieve, David. PY - 2018/6/6. Y1 - 2018/6/6. M3 - Abstract. T2 - British Cardiovascular Society Annual Conference. Y2 - 4 June 2018 through 5 June 2018. ER - ...
Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntingtons disease.: In order to investigate any effe
Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2) can potentially affect most of the events in cancer development, including promotion of proliferation, resistance to apoptosis, angiogenesis, immune suppression and invasion. However, worldwide attention has predominantly centered on the cardiovascular toxicity of selective COX-2 inhibitors. Paeonol is a major active extract from the root bark of Paeonia suffruticosa Andrews with anti‑inflammatory, anti-oxidant, anti-allergic, anti-oxidation and antitumor effects. In the present study, we investigated the underlying mechanisms of paeonol in inducing apoptosis and aimed to ascertain whether its antitumor effect is associated with a reduction in COX-2 expression and a decrease in the levels of PGE2 in colorectal cancer cells. We observed that paeonol inhibited cell proliferation and induced apoptosis in a dose- and time-dependent manner in colorectal cancer cells, which was associated with a reduction in COX-2 expression and ...
The molecular mechanisms and signaling pathways that get -cell compensation and failure are not fully resolved islet. FoxO1 in Pdx1-harmful -cells (14, 17). FoxO1 activity is certainly modulated by post-translational adjustments and protein-protein connections that influence its intracellular trafficking and function (18). In the -cell, development or insulin aspect PI3T/Akt-induced FoxO1 phosphorylation qualified prospects to its translocation from the nucleus to cytoplasm, alleviating its inhibition of focus on gene transcription (14). The incretin human hormones GIP and glucagon-like peptide 1 (GLP-1) also activate this series (19, 20). Another is certainly the stability between oxidative stress-induced FoxO1 acetylation and deacetylation (21). Hence, FoxO1 orchestrates -cell transcriptional regulatory paths for adaptive replies to many human hormones, development elements, and metabolic challenges. Whereas very much is certainly known about FoxO1 activity in -cells, very much much less is ...
This research is proposed in response to NIH Notice Number PA-07-320 (Development of assays for high-throughput drug screening). We have found that anti-oxidant...
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Acetophenone is the organic compound with the formula C₆H₅C(O)CH₃. It is the simplest aromatic ketone. This colourless, viscous liquid is a precursor to useful resins and fragrances ...
Inhibition of 4E-BP phosphorylation and function by perhexiline, niclosamide, amiodarone and rottlerin.MCF-7 cells stably expressing EGFP-LC3 were incubated wit
Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined the effect of type 2 diabetes on NADPH oxidase in human vessels and explored the mechanisms of this interaction. Segments of internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH oxidase-derived superoxide anions (O2˙(-)). The genetic variability of the ADIPOQ gene and circulating adiponectin (but not interleukin-6) were independent predictors of NADPH oxidase-derived O2˙(-). However, adiponectin expression in PVAT was positively correlated with vascular NADPH oxidase-derived O2˙(-). Recombinant adiponectin directly inhibited NADPH oxidase in human arteries ex vivo by preventing the activation/membrane translocation of Rac1 and downregulating p22(phox) through a
China Pure 98% Peony Bark Extract Paeonol, Find details about China Paeonol, Peony Bark Extract from Pure 98% Peony Bark Extract Paeonol - Nanjing Zelang Medical Technology Co., Ltd.
Flavones are widely distributed in nature and have been found to associated with a variety of biological activities as anticarcinogen, antiinflammatory and antifungals etc. The commonly used synthetic methods of flavone derivatives are as follows; the Kostanecki reaction, the Baker-venkataraman method, synthesis from chalcone, synthesis via an intramolecular Wittig strategy and lithiation reaction. In the present study, flavone derivatives containing methoxy or methyl groups were prepared by the following three steps; The first step was the synthesis of ortho-acetylphenylbenzoate derivatives from 2-hydroxyacetophenone derivatives and benzoyl chloride derivatives with DMAP as base in dichloroethane at 80℃. The second step was the intramolecular claisen condensation to form 1-(2-hydroxypheny1)-1,3-propanedione derivatives from ortho-acetylphenylbenzoate derivatives using potassium tert-butoxide in THF at 67℃. The third step was dehydrative cyclization to get the desired flavone derivatives ...
Melford Laboratories Ltd. is a leading supplier and manufacturer of research chemicals and biochemicals. Melford Laboratories Ltd. has over 300 chemicals in stock including plant tissue culture media, Biological buffers, and agarose. Melford Laboratories Ltd. are enzyme substrate suppliers that have the lowest prices in the industry on popular compounds IPTG �8/GM, X-Gal �30/GM, X-GlcA �54/100MG. Melford Laboratories Ltd. has a range of over 55 antibiotics which include hard to find compounds Zeocin and Cycloheximide. Research Melford Laboratories Ltd. has 17 years of experience manufacturing 4-Mu Substrates. Melford Laboratories Ltd. is best known for Fluorochemicals. Melford Laboratories Ltd. has methodology for the manufacture of numerous compound types, including Phenylhydrazines, Benzylamines, Benzaldhydes, Acetophenones, Sulphonyl chlorides, Bezonitriles, Benzyl alcohols, and Benzyl bromides.
Melford Laboratories Ltd. is a leading supplier and manufacturer of research chemicals and biochemicals. Melford Laboratories Ltd. has over 300 chemicals in stock including plant tissue culture media, Biological buffers, and agarose. Melford Laboratories Ltd. are enzyme substrate suppliers that have the lowest prices in the industry on popular compounds IPTG �8/GM, X-Gal �30/GM, X-GlcA �54/100MG. Melford Laboratories Ltd. has a range of over 55 antibiotics which include hard to find compounds Zeocin and Cycloheximide. Research Melford Laboratories Ltd. has 17 years of experience manufacturing 4-Mu Substrates. Melford Laboratories Ltd. is best known for Fluorochemicals. Melford Laboratories Ltd. has methodology for the manufacture of numerous compound types, including Phenylhydrazines, Benzylamines, Benzaldhydes, Acetophenones, Sulphonyl chlorides, Bezonitriles, Benzyl alcohols, and Benzyl bromides.
1. A scheme of synthesis was developped for cholecystokinin (CCK 26-33, using solid-phase methodology and successfully applied to the synthesis of its C- and N-terminal fragments. 2. Using CCK 30-33 as model, it was found that deprotection of the ?-phenacyl ester, with a 1 M solution of sodium thiophenoxide in DMF, leads to the formation of an aminosuccylnyl peptide, prior to ammonolysis. 3. Selenophenol reagent successfully removes the ?-phenacyl ester on protected CCK 32-33 and on protected CCK 30-33 polymer prior to ammonolytic cleavage of peptides from the resin. 4. Treatment of Boc-Asp(?-OPac)-Tyr(0-2,4-Dnp)-Met-Gly-Trp(Nin-For)-Met-Asp(?-OPac)-Phe-polymer with a 1 M solution of selenophenol in DMF, leads to irreversible rearrangement of the 0-2,4-dinitrophenyl ether. 5. Undesirable side-reactions can be avoided by sequential deprotections and cleavage. The 0-2,4-dinitrophenyl ether is removed by thiolysis following by selenolysis of the ?-phenacyl esters. Cleavage of the peptide from the ...
In atherosclerosis, local generation of reactive oxygen species amplifies the inflammatory response and contributes to plaque vulnerability. We used molecular imaging to test whether inhibition of NADPH oxidase with apocynin would reduce endothelial inflammatory activation and endothelial-platelet interactions, thereby interrupting progression to high-risk plaque phenotype. METHODS AND RESULTS: Mice deficient for both the low-density lipoprotein receptor and Apobec-1 were studied at 30 weeks of age and again after 10 weeks with or without apocynin treatment (10 or 50 mg/kg per day orally). In vivo molecular imaging of vascular cell adhesion molecule-1 (VCAM 1) P-selectin, and platelet glycoprotein-1balpha (GPIbalpha) in the thoracic aorta was performed with targeted contrast-enhanced ultrasound molecular imaging. Arterial elastic modulus and pulse wave transit time were assessed using ultrahigh frequency ultrasound and invasive hemodynamic measurements. Plaque size and composition were assessed ...
TY - JOUR. T1 - NADPH oxidase inhibitors. T2 - A decade of discovery from Nox2ds to HTS. AU - Cifuentes-Pagano, Eugenia. AU - Csanyi, Gabor. AU - Pagano, Patrick J.. PY - 2012/7/1. Y1 - 2012/7/1. N2 - NADPH oxidases (Nox) are established as major sources of reactive oxygen species (ROS). Over the past two decades, Nox-derived ROS have emerged as pivotal in the development of myriad diseases involving oxidative stress. In contrast, Nox are also involved in signaling mechanisms necessary for normal cell function. The study of these enzymes in physiological and pathophysiological conditions is made considerably more complex by the discovery of 7 isoforms: Nox1 through 5 as well as Duox1 and 2, each with its own specific cytosolic components, regulatory control mechanisms, subcellular localization and/or tissue distribution. A clear understanding of the role individual isoforms play in a given system is hindered by the lack of isoform-specific inhibitors. In animal models, knockdown or knockout ...
Possible factors regulating the opening of and the rate of H+ flux through a recently described, Cd(2+)-sensitive, phorbol ester- and arachidonic acid (AA)-activatable H(+)-conducting pathway in the plasma membrane of neutrophil granulocytes were investigated. (1) The phospholipase A2 blocker p-bromophenacyl bromide (BPB) inhibited the phorbol 12-myristate 13-acetate (PMA)-induced activation of this channel in a concentration-dependent manner (IC50, 4 microM). (2) Neither BPB nor the protein kinase C (PKC) inhibitor staurosporine influenced the AA-elicited stimulation of this route. (3) Intracellular acidification (cytoplasmic pH below 6.9) itself is capable of activating an electrogenic, Cd(2+)-sensitive H+ efflux indicating that protons can open up this route in the absence of any other stimulator. (4) PMA significantly decreases the intracellular H+ concentration ([H+]i) threshold for the opening of the channel, thus providing a conductive state at resting pH values, and elevates the rate of ...
Densities, viscosities, refractive indices and ultrasonic velocities of the binary mixtures of Acetophenone with Propyl acetate were measured over the entire mole fractions at (303.15, 313.15 and 323.15) K. From these experimental results, excess molar volumes VE, viscosity deviation ∆η, refractive index deviation ∆nD, deviations in isentropic compressibility ∆Ks and excess intermolecular free length ∆Lf are calculated. The viscosity values were fitted to the models of Krishnan- Laddha and McAllister. The thermo physical properties under study were fit to the Jouyban - Acree model. The excess values were correlated using Redlich-Kister polynomial equation to obtain their coefficients and standard deviations. It was found that in all cases, the data obtained fitted with the values correlated by the corresponding models very well. The results are interpreted in terms of molecular interactions occurring in the solution.
After the bromine has been added the ether and dissolved hydrogen bromide are removed at once (Note 4) under reduced pressure with a slight current of air. The phenacyl bromide remains as a solid mass of brownish yellow crystals (Note 5); the color is removed by shaking with a mixture of 10 cc. of water and 10 cc. of petroleum ether. The crystals are filtered with suction and washed several times with fresh portions of the solvent mixture, if necessary, until a white product is obtained (Note 6). The crude phenacyl bromide weighs 74-80 g. (88-96 per cent of the theoretical amount) and melts at 45-48°. This material is sufficiently pure for many purposes. If higher purity is desired the crude product may be recrystallized from 25-30 cc. of methanol, yielding 54-55 g. (64-66 per cent of the theoretical amount) of white crystals melting at 49-51° (Note 7) ...
Globally, noncommunicable chronic diseases such as for example Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. (NLRs), Rig-1-like receptors (RLRs), and C-type lectin like receptors (CLRs) and metabolic endotoxemia in fuelling metainflammation in DM-CAD would be discussed. Further, the part played by adaptive immune cells (Th1, Th2, Th17, and Th9 cells) in fuelling metainflammation in DM-CAD will also be discussed. 1. Introduction In recent years, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world irrespective of geographical and ethnic boundaries [1]. T2DM is known to potentiate CAD which experienced led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality [1]. The synergistic connection between these two comorbidities is definitely through sterile swelling which is now being tackled ...
NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery wall in conditions such as hypertension, hypercholesterolaemia, diabetes and ageing, and so they are important contributors to the oxidative stress, endothelial dysfunction and vascular inflammation that underlies arterial remodelling and atherogenesis. In this Review, we advance the concept that compared to the use of conventional antioxidants, inhibiting NOX1 and NOX2 oxidases is a superior approach for combating oxidative stress. We briefly describe some common and emerging putative NADPH oxidase inhibitors. In addition, we highlight the crucial role of the NADPH oxidase regulatory subunit, p47phox, in the activity of vascular NOX1 and NOX2 oxidases, and suggest how a better understanding of its specific molecular interactions may enable the development of novel isoform-selective drugs to prevent or treat cardiovascular ...
Methods of selective methylation of the nitrogen atoms of the ethyl ester of 3‐(1H‐imidazol‐4‐yl)‐2‐propenoic acid are reported. The nitrogen atom α to the ethylenic chain was methylated after protection of the β nitrogen with a phenacyl group. ...
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KANCHANAPOOM, Tripetch; NOIARSA, Pawadee; TIENGTHAM, Pimonporn; OTSUKA, Hideaki; RUCHIRAWAT, Somsak (2005). "Acetophenone ... Two new acetophenone diglycosides, erythroxylosides A and B; two known flavans, one known flavonol glycoside and two known ...
Acetophenone Butyrophenone Propiophenone Milstein, D.; Stille, J. K. (1978). "A general, selective, and facile method for ...
In one example, mice were conditioned to fear a strong scent, acetophenone, by accompanying the smell with an electric shock. ... Consequently, the mice learned to fear the scent of acetophenone alone. It was discovered that this fear could be passed down ... Despite the offspring never experiencing the electric shock themselves the mice still display a fear of the acetophenone scent ...
... acetophenone, and related substances". American Chemical Journal. 42 (6): 477-498. Hocking, M. B.; Bhandari, K.; Shell, B.; ...
The α-bromination of acetophenone with bromine. Liesegang rings Autocatalytic surface growth of metal nanoparticles in solution ...
Substituted acetophenones can be converted to the corresponding phenyl acetates at 30 °C in high yields. The rate is about 100 ... "Kinetics of the Baeyer-Villiger Reaction of Acetophenones with Permonophosphoric Acid". J. Org. Chem. 43 (12): 2417-2419. doi: ...
D. E. Pearson; H.W. Pope (March 1956). "The Swamping Catalyst Effect in Bromination of Acetophenone". Journal of Organic ... "The Swamping Catalyst Effect in Bromination of Acetophenone" which, as the term he coined implies, describes the use of larger ...
Coordination of another acetophenone molecule regenerates complex 2. Kakiuchi, Fumitoshi; Kochi, Takuya (2008-10-01). " ... acetophenone coordinates to the complex via its carbonyl oxygen and agostically via its ortho C-H bond (2). As in the Ru0 ...
Acetophenone (C6H5C(O)CH3) is an unsymmetrical ketone. Many kinds of diketones are known, some with unusual properties. The ...
In the second reaction sequence, [Carbonyl-14C]-2-hydroxy-acetophenone was used first. Compound XII was formed from ... condensation of [carbonyl-14C-]-2-hydroxy-acetophenone with dimethyl oxylate and ring closure. Hydrogenolytical debenzylation ...
Myrboh, B.; Ila, H.; Junjappa, H. (1981). "One-Step Synthesis of Methyl Arylacetates from Acetophenones Using Lead(IV) Acetate ... Oxidative cleavage of certain allyl alcohols in conjunction with ozone: conversion of acetophenones to phenyl acetic acids ...
... and acetophenones which may have adverse health effects. Sun protection factor "Making Cosmetics®, Avobenzone". Makingcosmetics ...
provided by RefSeq, Jul 2008]. Ketones, in particular acetophenone, act as agonists for OR1E3. From associations to other ...
DBM is prepared by condensation of ethyl benzoate with acetophenone. Like other 1,3-diketones (or their enols), DBM condenses ...
70, p. 35 (1992). Article Reaction of acetophenone with methylamine in Organic Syntheses, Coll. Vol. 6, p. 818 (1988); Vol. 54 ...
1887). 'Cases Illustrating the Sedative Effects of Aceto-phenone (hypnone)'. Journal of Mental Science. 32: 519-25. (1887). ' ...
The methyl group of acetophenone was brominated with bromine to give α-bromoacetophenone, which was then reacted with N- ... A synthesis using "classical" methodology was reported by Durden and co-workers, starting from acetophenone. ...
Benzoin ethers, Acetophenones, Benzoyl Oximes, and Acylphosphines are some examples of cleavage-type photoinitiators. Cleavage ...
... acetophenones". Arkivoc. 2005 (6): 356-365. doi:10.3998/ark.5550190.0006.631. Gus J. Palenik, George Raymond Clark "Crystal and ...
"Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor". ...
This compound may be prepared by the reductive amination of acetophenone. One major route for this chemical uses the Mignonac ...
... acetophenone". Org. Synth. 82: 115. doi:10.15227/orgsyn.082.0115.CS1 maint: uses authors parameter (link) W. Voskuil and J. F. ...
Johnnie L. Leazer, Jr; Raymond Cvetovich (2005). "A Practical and Safe Preparation of 3,5-Bis(trifluoromethyl)acetophenone". ...
... , also commonly known as chloroacetophenone, is a substituted acetophenone. It is a useful building block in ... Phenacyl chloride is readily available and was first prepared by chlorination of acetophenone vapour. It may be also be ...
Compounds isolated from the plant include flavonoids, sesquiterpenoids, monoterpenoids, acetylenes, p-acetophenones, ...
... the latter of which quickly breaks down to acetophenone. Acetophenone is then reduced to an alcohol and conjugated by ... Chlorfenvinphos is produced by reaction of triethylphosphite (P(OEt)3) with 2,2,2,4-tetrachloro acetophenone (C8H4Cl4O). In the ...
Products of decomposition of cumene hydroperoxide are methylstyrene, acetophenone, and cumyl alcohol. Its formula is C6H5C(CH3) ...
The result indicated that the products contain styrene, acetophenone, and brominated substances, which can negatively affect ...
This method lead to the reduction of substituted acetophenones in up to 83%ee (Figure 5). The appeal of this method is that it ...
Asymmetric hydrogenation of acetophenone by Noyori catalysts proceeds quantitatively (50 atm H2, room temperature, minutes) in ... Racemic 1-phenylethanol is produced by the reduction of acetophenone by sodium borohydride. Alternatively, benzaldehyde can be ...
... in the process with a small amount of by-product acetophenone. Acetophenone is recovered or hydrogenated to 1-phenylethanol ... Acetophenone is the organic compound with the formula C6H5C(O)CH3 (also represented by the pseudoelement symbols PhAc or BzMe ... Acetophenone is an ingredient in fragrances that resemble almond, cherry, honeysuckle, jasmine, and strawberry. It is used in ... In instructional laboratories, acetophenone is converted to styrene in a two-step process that illustrates the reduction of ...
Acetophenone carboxylase (EC 6.4.1.8) is an enzyme with systematic name acetophenone:carbon-dioxide ligase (ADP-forming). This ... Acetophenone+carboxylase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... Jobst B, Schühle K, Linne U, Heider J (March 2010). "ATP-dependent carboxylation of acetophenone by a novel type of carboxylase ... enzyme catalyses the following chemical reaction 2 ATP + acetophenone + HCO3− + H2O + H+ ⇌ {\displaystyle \rightleftharpoons } ...
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Acetophenone is resistant to hydrolysis under environmental conditions. Ketones (e.g. acetophenone) are generally resistant to ...
Acetophenone. CASRN 98-86-2 , DTXSID6021828. *IRIS Summary (PDF) (9 pp, 98 K) ...
The REACH registered substance data and the C&L Inventory portal will be upgraded from the 9th November.. Please be aware there may be intermittent unavailability while work in ongoing. The per substance REACH registration status will be made available as soon as possible thereafter. Likewise the per substance indication of harmonised C&L, Seveso directive, or notified C&L regulatory context will be made available as soon as possible.. Please note that it may take a week or two to have everything fully in place, and please be aware in the meantime that the Registration status may be incorrect and the CLP regulatory context may be incompletely shown.. ...
Acetophenone is a crystalline ketone that is used as a solvent for cellulose ethers and esters in the manufacture of alcohol- ... Acetophenone is used to create fragrances that resemble almond, cherry, honeysuckle, jasmine, and strawberry. It is used in ... Currently acetophenone mainly comes as a by-product of the phenol-acetone synthesis in the cumene oxidation process. At one ... In a 1994 report released by five top cigarette companies, acetophenone was listed as one of the 599 additives to cigarettes.[1 ...
4-Dichloro-5-fluoro Acetophenone (CAS 704-10-9) Market 2017: Industry Demand, Insight & Forecast By 2022 - published on openPR. ... Acetophenone Market Size, Share, Development by 2024 Global Info Research offers a latest published report on Acetophenone ... Acetophenone Market to Reflect Steady Growth During 2015-2025 Increasing consumption of Acetophenone in various applications ... Acetophenone Market Trends, Forecast, Segments 2015-2025 Increasing consumption of Acetophenone in various applications such as ...
Acetophenone is the precursor used in the manufacturing of styrene. Physical. Acetophenone is a colorless liquid at ... Acetophenone is an organic compound, the simplest aromatic ketone. It has the formula C6H5C(O)CH3. ... Retrieved from "http://www.sciencemadness.org/smwiki/index.php?title=Acetophenone&oldid=13923" ...
... acetophenone; CAS Number: 59824-23-6; Linear Formula: C15H11NO; find Rieke Metals, Inc.-RIE156323220 MSDS, related peer- ...
Bacterial Degradation of Ring-Chlorinated Acetophenones Message Subject (Your Name) has forwarded a page to you from Applied ... Bacterial Degradation of Ring-Chlorinated Acetophenones. Frank K. Higson, Dennis D. Focht ... strain ACA and Pseudomonas fluorescens ACB, isolated from acetophenone and 4′-hydroxyacetophenone enrichments, respectively, ... cometabolize a range of chlorinated acetophenones (CAs). A biological Baeyer-Villiger reaction converts the CA to chlorophenyl ...
Lamani, M. and Prabhu, K. R. (2012), NIS-Catalyzed Reactions: Amidation of Acetophenones and Oxidative Amination of ...
Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
where to buy 30071-93-3(3,5-Bis(trifluoromethyl)acetophenone).Also offer free database of 30071-93-3(3,5-Bis( ... trifluoromethyl)acetophenone) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, ... acetophenone;3,5-Bis(trifluoromethyl)phenyl methylketone;3,5-Di(trifluoromethyl)acetophenone;Ethanone,1-[3,5-bis( ... Acetophenone,3,5-bis(trifluoromethyl)- (8CI);1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-one;1-[3,5-Bis(trifluoromethyl)phenyl] ...
Mentions de prudence: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant ...
... we successfully developed a novel and sensitive gas sensor for the determination of trace acetophenone based on its ... Under the optimized conditions, the sensor exhibited linear response to the acetophenone in the range of 15-280 mg/m (2.8-52 ... In this work, we successfully developed a novel and sensitive gas sensor for the determination of trace acetophenone based on ... Finally, the present sensor was applied to the determination of acetophenone in human exhaled breath samples. The results ...
Charlotte De Fré; Ola Bergendorff; Nadia Raison‐Peyron; Karen van de Voorde; Elien Romaen; Julien Lambert; Christina Persson; Olivier Aerts + Author Information ...
We take acetophenone as a test molecule, for which accurate ab initio results exist in the literature. Triplet acetophenone is ... 74 ATOMIC AND MOLECULAR PHYSICS; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACETOPHENONE; DENSITY FUNCTIONAL ... Title: Triplet state photochemistry and the three-state crossing of acetophenone within time-dependent density-functional ... Journal Article: Triplet state photochemistry and the three-state crossing of acetophenone within time-dependent density- ...
Acetophenone solution, certified reference material, 2000 μg/mL in methylene chloride C8H8O ... New flav-3-en-3-ol glycosides, kaempferiaosides C and D, and acetophenone glycosides, kaempferiaosides E and F, from the ... Two new flav-3-en-3-ol glycosides, kaempferiaosides C (3) and D(4), and two new acetophenone glycosides, kaempferiaosides E (5 ...
5-alkylated acetophenones and methyl benzoate derivatives respectively via an anionic domino process. ... One pot synthesis of 3,5-alkylated acetophenone and methyl benzoate derivatives via an anionic domino process R. Ballini, L. ... One pot synthesis of 3,5-alkylated acetophenone and methyl benzoate derivatives via an anionic domino process ...
N′-dioxides and their application in asymmetric allylation of benzaldehyde and aldol addition to acetophenone. ... benzaldehyde with allyltrichlorosilane and aldol reaction of trichlorosilyl ketene acetal of methyl acetate with acetophenone. ...
... synthesis of acetophenone as a widely used industrial compound was investigated by liquid phase oxidation of ethylbenzene with ... Selective liquid phase oxidation of ethyl benzene to acetophenone by palladium nanoparticles immobilized on a g-C3N4-rGO ... Selective liquid phase oxidation of ethyl benzene to acetophenone by palladium nanoparticles immobilized on a g-C3N4-rGO ... In this study, synthesis of acetophenone as a widely used industrial compound was investigated by liquid phase oxidation of ...
Mast cell stabilizing effect of a geranyl acetophenone in dengue virus infection using in vitro model of DENV3-induced RBL-2H3 ... 2,4,6-trihydroxy-3-geranyl acetophenone (tHGA) has been reported to be a potential MC stabilizer by inhibiting IgE-mediated MC ... tHGA is a geranyl acetophenone originally found in the young leaves of Melicope ptelefolia. It is also a phloroglucinol ... A geranyl acetophenone targeting cysteinyl leukotriene synthesis prevents allergic airway inflammation in ovalbumin-sensitized ...
... Ekegren, Jenny ... The ligands have been evaluated in the asymmetric Ir-catalyzed transfer hydrogenation of acetophenone. The complexes evaluated ...
acetophenone antagonizes verteporfin a2a receptors in the ventrolateral preoptic hypothalamic area. He there also said he felt ... acetophenone antagonizes verteporfin a2a receptors in the ventrolateral preoptic hypothalamic area. He there also said he felt ... How does your Visudyne use Acetophenone in food? November 17, 2018 Health hazard ...
Four new acetophenone di- C-glycosides, pteleifolols A-D ( 1- 4) and a new dimeric benzopyran, pteleifolol E ( 5), were ... Four new acetophenone di-C-glycosides, pteleifolols A-D (1-4) and a new dimeric benzopyran, pteleifolol E (5), were isolated ... Pteleifolols A-E, acetophenone di-C-glycosides and a benzopyran dimer from the leaves of Melicope pteleifolia ... Melicope pteleifolia Rutaceae Acetophenone Dimeric benzopyran Pteleifolols A-E This is a preview of subscription content, log ...
5-Difluoro acetophenone 123577-99-1 product and the products related with China 3,5-Difluoro acetophenone 123577-99-1 - jtlchem ... 5-Difluoro acetophenone 123577-99-1 Suppliers and China 3,5-Difluoro acetophenone 123577-99-1 Manufacturers, provide 3, ... 3,5-Difluoro acetophenone. Category : Pharmaceuticals and Biochemicals. CAS NO : 123577-99-1. EC NO : Molecular Formula : C8H6F ... Send your inquiry to 3,5-Difluoro acetophenone supplier. Enter your inquiry here and then click Send. Enter between 20 to 3,000 ...
Structures of Hydrocarbons From the Polyphosphoric Acid Induced Condensation of Acetophenone. Welcome to the IDEALS Repository ... Structures of Hydrocarbons From the Polyphosphoric Acid Induced Condensation of Acetophenone. Bush, Richard Wayne ...
Important enzymological data of the dehydrogenase are: K m (acetophenone) 0.6 mM, K m (NADPH) 0.14 mM, and a pH optimum for ... Besides acetophenone several other aromatic and long-chain aliphatic secondary ketones are substrates for this enzyme. Batch ... acetophenone reduction at 7.0. Addition of EDTA leads to complete deactivation of the enzyme activity. Added iodoacetamide or p ... A new alcohol dehydrogenase catalysing the enantioselective reduction of acetophenone to R(+)-phenylethanol was found in a ...
  • Modified acetophenone-formaldehyde resins are produced by the hydrogenation of the aforementioned ketone-containing resins. (wikipedia.org)
  • Acetophenone is a crystalline ketone that is used as a solvent for cellulose ethers and esters in the manufacture of alcohol -soluble resins . (wikidoc.org)
  • Acetophenone is an organic compound, the simplest aromatic ketone. (sciencemadness.org)
  • Acetophenone is the simplest aromatic ketone organic compound and it has a sweet taste and smell that resembles that of oranges. (niir.org)
  • Synthesis and evaluation of N,S-compounds as chiral ligands for transfer hydrogenation of acetophenone. (diva-portal.org)
  • The ligands have been evaluated in the asymmetric Ir-catalyzed transfer hydrogenation of acetophenone. (diva-portal.org)
  • 4-9 were used as catalysts for the transfer hydrogenation of acetophenone. (comu.edu.tr)
  • For the transfer hydrogenation of acetophenone, 7-9 had similar activity to 4-6. (comu.edu.tr)
  • The reaction of primary 1,3-dinitroalkanes with 2-ene-1,4-dione or 2-ene-4-oxo ester derivatives in acetonitrile with DBU as base, allow the one pot synthesis of 3,5-alkylated acetophenones and methyl benzoate derivatives respectively via an anionic domino process. (rsc.org)
  • In this study, synthesis of acetophenone as a widely used industrial compound was investigated by liquid phase oxidation of ethylbenzene with TBHP as an oxidant in acetonitrile over Pd/g-C 3 N 4 -rGO as a recyclable catalyst. (rsc.org)
  • Leadeing Manufacturer & Exporter of Acetophenone, Acetonitrile acetophenone cclohexane diethyl malonate diethylene triamine dimethyl carbonate etc. (exportersindia.net)
  • Leading Manufacturer & Supplier of Acetophenone, Acetone acetonitrile / acrylonitrile acetophenone / acrylic acid acrylamide / amiyl acetate etc. (exportersindia.net)
  • Acetophenone is used for the synthesis of many pharmaceuticals. (wikipedia.org)
  • Currently acetophenone mainly comes as a by-product of the phenol - acetone synthesis in the cumene oxidation process. (wikidoc.org)
  • Synthesis of Nano-Praseodymium Oxide for Cataluminescence Sensing of Acetophenone in Exhaled Breath. (americanelements.com)
  • Zhang Q-, Yan W-, Jiang L, Zheng Y-, Wang J-, Zhang R-. Synthesis of Nano-Praseodymium Oxide for Cataluminescence Sensing of Acetophenone in Exhaled Breath. (americanelements.com)
  • Synthesis of 2-hydroxy-3-bromo-4-nitro-5-methyl acetophenone (I) p-cresyl acetate was prepared by known method. (corso-massaggiobari.it)
  • The subsequent carboxylation of acetophenone to benzoylacetate is catalyzed by an acetophenone-induced enzyme, which has been purified and studied. (semanticscholar.org)
  • The N,N′ -dioxides were used as catalysts in enantioselective allylation of benzaldehyde with allyltrichlorosilane and aldol reaction of trichlorosilyl ketene acetal of methyl acetate with acetophenone. (springer.com)
  • The syntheses of six prenylated acetophenone and benzaldehyde derivatives and their anti-phytopathogenic and antioxidant activities are reported. (conicyt.cl)
  • We show that the odorants acetophenone and benzaldehyde are agonists for the M71 OR and that M71-expressing neurons are functionally similar in their response properties across concentration. (jneurosci.org)
  • [0001] This invention relates to novel substituted acetophenones and derivatives thereof, processes for the preparation thereof, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments. (patentsencyclopedia.com)
  • In view of the unexpected behavior of α-(benzenesulfonyl)-acetophenone toward hydrolysis and because of the possible physiological importance of its derivatives it was deemed of interest to make a further study of the hydrolysis of this compound. (unt.edu)
  • Acetophenone is a colorless liquid at temperatures higher than room temperature and a solid at lower temperatures, making it an interesting chemical compound. (sciencemadness.org)
  • Acetophenone is a colorless liquid with a sweet pungent taste. (niir.org)
  • Acetophenone is recovered as a by-product of the oxidation of ethylbenzene to ethylbenzene hydroperoxide. (wikipedia.org)
  • Moreover, this system revealed a good performance in the production of acetophenone as the main product of oxidation of ethylbenzene under mild conditions with 67% and 97% conversion and selectivity, respectively. (rsc.org)
  • Anaerobic ethylbenzene metabolism in the betaproteobacterium Aromatoleum aromaticum is initiated by anaerobic oxidation to acetophenone via (S)-1-phenylethanol. (semanticscholar.org)
  • Bulk samples were analyzed for formaldehyde (50000) and acetophenone (98862) at Lion Uniform Company (SIC-2328), Beattyville, Kentucky in 1983. (cdc.gov)
  • Acetophenone carboxylase (EC 6.4.1.8) is an enzyme with systematic name acetophenone:carbon-dioxide ligase (ADP-forming). (wikipedia.org)
  • We are one of the leading manufacturer of Acetophenone, 4-methoxy-3-nitro benzoic acid, 4-chloro-3-nitor- benzooic acid, 2-cloro and 5 nitro benjoic acid , organic intermediates and bulk drugs like benzophenones, acetophenones, ester, acids & amides, quaternary ammonium salts inorganic salt. (exportersindia.net)
  • We are a trusted professional exporter of Acetophenone Series & Intermediates established since 36 Years 7 Months 19 Days in the city of Mumbai. (connect2india.com)
  • Manufacturers and Suppliers of Acetophenone, Bulk drug intermediates,drugs & medications,pharmaceutical chemicals,chemical supplies,pharmaceutical raw material,manufacturers & exporters of ibuprofen bp/ usp/ ep & it? (exportersindia.net)
  • intermediates, isobutyl acetophenone, isobutyl phenyl propanaldehyde & inter. (exportersindia.net)
  • Exporters India , A B2B online Acetophenone and Acetophenone Products business directory & Yellow Pages of India providing a comprehensive listings of Acetophenone Products companies engaged in manufacturing & supply. (exportersindia.net)
  • Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also induce hippuric acid in urine. (wikipedia.org)
  • The names acetophenone and benzophenone are retained only for general nomenclature, but no substitution is allowed. (wikipedia.org)
  • Buyers can browse the catalogs of Acetophenone Products manufacturers & suppliers and send a request for product details or query. (exportersindia.net)
  • Commercially significant resins are produced from treatment of acetophenone with formaldehyde and a base. (wikipedia.org)
  • Bulk samples had residual formaldehyde concentrations of 260 to 450 parts per million (ppm) and 33,500 to 46,500ppm acetophenone. (cdc.gov)
  • Recommendations include providing exhaust ventilation, increasing the outside air component in the general ventilation system, cooperating with textile mills to obtain fabrics with minimal concentrations of latent formaldehyde and acetophenone, and airing the fabrics to allow outgassing of formaldehyde. (cdc.gov)
  • C6H5C(O)CH3 + H2 → C6H5CH(OH)CH3 Being prochiral, acetophenone is also a popular test substrate for asymmetric hydrogenation experiments. (wikipedia.org)
  • Acetophenone is the organic compound with the formula C6H5C(O)CH3 (also represented by the pseudoelement symbols PhAc or BzMe). (wikipedia.org)
  • Densities, viscosities, refractive indices and ultrasonic velocities of the binary mixtures of Acetophenone with Propyl acetate were measured over the entire mole fractions at (303.15, 313.15 and 323.15) K. From these experimental results, excess molar volumes V E , viscosity deviation ∆η, refractive index deviation ∆n D , deviations in isentropic compressibility ∆K s and excess intermolecular free length ∆L f are calculated. (sapub.org)
  • Acetophenone and propyl acetate mixture was used in the manufacture of cosmetics amd fruit flavouring agents. (sapub.org)
  • In continuation of this research, we have reported density ( ρ ), viscosity ( η ), refractive index ( n D ) and sound speed ( u ) of pure acetophenone and propyl acetate for the binary system constituted by these two chemicals at temperatures of 303.15, 313.15 and 323.15 K. The viscosity values have been fitted to McAllister[6] and Krishnan and Laddha[7] model. (sapub.org)
  • Acetophenone is recovered or hydrogenated to 1-phenylethanol which is then dehydrated to produce styrene. (wikipedia.org)
  • In instructional laboratories, acetophenone is converted to styrene in a two-step process that illustrates the reduction of carbonyls using hydride and the dehydration of alcohols: 4 C6H5C(O)CH3 + NaBH4 + 4 H2O → 4 C6H5CH(OH)CH3 + NaOH + B(OH)3 → C6H5CH=CH2 A similar two-step process is used industrially, but reduction step is performed by hydrogenation over a copper catalyst. (wikipedia.org)
  • Acetophenone is the precursor used in the manufacturing of styrene. (sciencemadness.org)
  • The same enzyme is involved in acetophenone metabolism in the absence of ethylbenzene. (semanticscholar.org)
  • We are Manufacturers of Acetophenone, Acetophenone allyl alcohol aminoguaidine bicarbonate ammonium persulfate bis carbonate malonic acid malononitrile maltol methyl acetoacetate methyl chloroformate methyl cyclohexane etc. (exportersindia.net)
  • Ethylbenzene hydroperoxide is primarily converted to 1-phenylethanol (α-methylbenzyl alcohol) in the process with a small amount of by-product acetophenone. (wikipedia.org)
  • This enzyme catalyses the following chemical reaction 2 ATP + acetophenone + HCO3− + H2O + H+ ⇌ {\displaystyle \rightleftharpoons } 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate The enzyme is involved in anaerobic degradation of ethylbenzene. (wikipedia.org)
  • Santappa, M. (1978) Vinyl polymerization: Kinetics of Ce(IV)-acetophenone-initiated polymerization of acrylonitrile in acetic-sulfuric acid mixtures Journal of Polymer Science - Polymer Chemistry Edition, 16 (2). (ias.ac.in)
  • The polymerization of acrylonitrile (M) initiated by the Ce(IV)-acetophenone (AP) redox pair has been studied in acetic-sulfuric acid mixtures in a nitrogen atmosphere. (ias.ac.in)
  • Acetophenone should be mixed with a more flammable solvent and incinerated. (sciencemadness.org)
  • In a 1994 report released by five top cigarette companies, acetophenone was listed as one of the 599 additives to cigarettes. (wikidoc.org)
  • Chen KT, Lin LC, Chou CJ, Chen CF (1994) A novel acetophenone di- C -glycoside from Melicope pteleifolia fruit. (springer.com)
  • The chemical Acetophenone , which is obtained by the dry distillation of the calcium salts of acetic acid and other acids, is used for ethers in the making of alcohol-soluble resins. (hubpages.com)
  • The present study was undertaken, using isometric tension change measurement and whole-cell patch-clamp electrophysiology methods, to evaluate the vascular relaxation effect and the underlying mechanisms involved of two naturally found alkaloids: paeonol (2-hydroxy-4-methoxy-acetophenone), acetovanillone (4-hydroxy-3-methoxy-acetophenone) and the non-substituted analogue acetophenone on pulmonary artery of Sprague-Dawley rats. (edu.au)
  • Endothelial denudation and inhibition of nitric oxide synthase (with 20 μM NG-nitro-l-arginine methyl-ester) only moderately suppressed (17.6 ± 4.2%) acetovanillone- but not paeonol- or acetophenone-mediated maximum relaxation. (edu.au)
  • In electrophysiological experiments using single pulmonary artery smooth muscle cells, acetovanillone, paeonol, acetophenone and cromakalim activated glibenclamide-sensitive, IKATP channels. (edu.au)
  • Acetophenone is used to create fragrances that resemble almond , cherry , honeysuckle , jasmine , and strawberry . (wikidoc.org)
  • The fragrances that could be created with acetophenone are strawberry, jasmine, cherry, almond and honeysuckle. (hubpages.com)
  • A new alcohol dehydrogenase catalysing the enantioselective reduction of acetophenone to R(+)-phenylethanol was found in a strain of Lactobacillus kefir. (semanticscholar.org)
  • Here, we used diverse association genetics approaches to discover genes and their variants that may control the accumulation of acetophenones, and dissect the genetic architecture of these defence compounds against SBW in white spruce mature trees. (biomedcentral.com)
  • Acetophenone exposure also may have contributed to the symptoms, although little is known about its toxicity. (cdc.gov)
  • Acetophenone is an important industrial chemical widely used as an ingredient of flavour and fragrance in soaps, detergents, cosmetics and perfumes. (sapub.org)
  • Acetophenones and benzaldehydes are versatile molecules and are widely used as precursors to other natural products such as flavonoids. (conicyt.cl)
  • Acetophenone is currently listed as a Group D carcinogen indicating that it does not produce carcinogenic effects in humans. (wikipedia.org)
  • Engaged in supplying and export of Acetophenone, 4-methoxy acetophenone acrylic acid butylated hydroxy anisole-bha calcium gluconate calcium lactate di ethyl malonate etc. (exportersindia.net)
  • In addition, the proposed catalyst also retained its activity and selectivity for acetophenone after 5 runs. (rsc.org)
  • Therefore, the effect of SiO2 was investigated as a catalyst and the results show that excess silicon(IV) oxide was a surprisingly active catalyst for the hydrogenation of acetophenone under these conditions. (comu.edu.tr)