Compounds in which a methyl group is attached to the cyano moiety.

Efficient nitroso group transfer from N-nitrosoindoles to nucleotides and 2'-deoxyguanosine at physiological pH. A new pathway for N-nitrosocompounds to exert genotoxicity. (1/350)

The endogenous formation of N-nitrosoindoles is of concern since humans are exposed to a variety of naturally occurring and synthetic indolic compounds. As part of a study to evaluate the genotoxicity of N-nitrosoindoles, the reactions of three model compounds with purine nucleotides and 2'-deoxyguanosine at physiological pH were investigated. The profiles of reaction products were identical for each of the N-nitrosoindoles and three distinct pathways of reaction could be discerned. These pathways were: (i) depurination to the corresponding purine bases, (ii) deamination, coupled with depurination, to give hypoxanthine and xanthine, and (iii) formation of the novel nucleotide 2'-deoxyoxanosine monophosphate and its corresponding depurination product oxanine in reactions with 2'-deoxyguanosine monophosphate. 2'-Deoxyoxanosine and oxanine were observed in reactions with 2'-deoxyguanosine. Further studies showed that formation of all of these products could be rationalized by an initial transnitrosation step. These results suggest that, in contrast to many other genotoxic N-nitrosocompounds which are known to alkylate DNA, the genotoxicity of N-nitrosoindoles is likely to arise through transfer of the nitroso group to nucleophilic sites on the purine bases. All of the products resulting from transnitrosation by N-nitrosoindoles are potentially mutagenic. These findings reveal a new pathway for N-nitrosocompounds to exert genotoxicity.  (+info)

Studies of structure and mechanism in acetonitrile chemical ionization tandem mass spectrometry of polyunsaturated fatty acid methyl esters. (2/350)

Recently it has been shown that acetonitrile chemical ionization tandem mass spectrometry (CI-MS/MS) is a rapid, on-line means to determine double bond position in fatty acid methyl esters (FAME). The mechanism of this gas phase condensation reaction has been studied. Evidence of the (1-methyleneimino)-1-ethenylium ion (m/z 54), formed upon the reaction of acetonitrile with itself, adding across the double bond in a [2 + 2] cycloaddition reaction is observed. When this nascent complex undergoes collision-induced dissociation, two diagnostic ions emerge. One of these ions results from loss of the hydrocarbon end of the FAME, whereas the other ion results from loss of the methyl ester end, and when considered together, the diagnostic ions localize the positions of the double bonds in the FAME. Several labeling and MS/MS/MS experiments on the two diagnostic ions were performed to determine a plausible fragmentation mechanism of the stable (1-methyleneimino)-1-ethenylium-FAME complex. The first generation product ions, or diagnostic ions, appear to be formed though a charge-driven mechanism, whereas the second generation product ions are formed via charge-remote fragmentations. Plausible mechanisms for the formation and subsequent dissociation of the diagnostic ions are presented for the monounsaturated, diunsaturated, and polyunsaturated (3 or more double bonds) FAME.  (+info)

Stimulation of tolbutamide hydroxylation by acetone and acetonitrile in human liver microsomes and in a cytochrome P-450 2C9-reconstituted system. (3/350)

Organic solvents are often used to solubilize lipophilic new chemical entities before their addition to in vitro test systems such as microsomal stability or cytochrome P-450 (CYP) inhibition. However, the effect of these organic solvents on the test systems is not usually characterized. This study was initiated to evaluate the effect of acetonitrile and acetone, in addition to other organic solvents, on the tolbutamide hydroxylation activity of CYP2C9 in both human liver microsomes and a CYP2C9-reconstituted system. Both acetonitrile and acetone significantly stimulated the NADPH-dependent tolbutamide hydroxylation by nearly 2- to 3-fold in human liver microsomes and CYP2C9-reconstituted system when incubated at 2 and 4% final solvent concentrations. When cumene hydroperoxide was used instead of NADPH, both acetone and acetonitrile significantly inhibited tolbutamide hydroxylation. This NADPH-dependent stimulatory effect was further evaluated by examining the effect of a series of other organic solvents with different carbon chain lengths and various functional groups, including hydroxyl, ketone, and aldehyde. Unlike acetone, two other ketone-containing solvents, methyl ethyl ketone (2-butanone) and diethyl ketone (3-pentanone) failed to significantly enhance tolbutamide hydroxylation. Other solvents tested, including methanol, ethanol, propanol, 1-butanol, 2-butanol, 1-pentanol, 2-pentanol, acetaldehyde, and dimethyl sulfoxide significantly inhibited NADPH-dependent tolbutamide hydroxylation. Overall, the stimulatory effect of both acetonitrile and acetone on tolbutamide hydroxylation was found to be primarily due to a consistent increase in V(max), whereas K(m) was unchanged in both human liver microsomes and the reconstituted CYP2C9 system. These data suggest that acetone and acetonitrile stimulate NADPH-mediated tolbutamide hydroxylation via the CYP reductase and not by modifying the affinity of tolbutamide for the CYP2C9 enzyme.  (+info)

Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity. (4/350)

Acetonitrile is an organic solvent commonly used to increase the solubility of lipophilic substrates for in vitro studies. In this study, we examined its effect on four reactions (diclofenac hydroxylation, tolbutamide methyl hydroxylation, phenytoin hydroxylation, and celecoxib methyl hydroxylation) catalyzed by human liver microsomes and by the recombinant CYP2C9. In both cases, the effect of acetonitrile on activity was found to be substrate-dependent. Namely, it increased diclofenac 4'-hydroxylase and tolbutamide methyl hydroxylase activities, but decreased celecoxib methyl hydroxylase activity in a concentration-dependent manner. By comparison, hydroxylation of phenytoin was resistant to its effect. The presence of acetonitrile (3%, v/v) gave rise to a lower K(m) and a higher V(max) for diclofenac hydroxylase in both liver microsomes and recombinant CYP2C9 preparations (87 and 52% increase in V(max)/K(m) ratio, respectively). On the other hand, the inhibitory effect of the solvent (1%, v/v) toward celecoxib hydroxylase was characterized by a decrease in V(max) (human liver microsomes) or a change in both K(m) and V(max) (rCYP2C9), leading to 25 and 46% decrease in V(max)/K(m) for both systems. The results of this study underscore the need for careful evaluation of solvent effects before initiation of inhibition or cytochrome P450 reaction phenotyping studies.  (+info)

High-throughput method development approaches for bioanalytical mass spectrometry. (5/350)

A rational approach to the development and optimization of solid-phase extraction (SPE) methods is described. The semiautomated scheme allows for the simultaneous testing of multiple chemistries using a custom multiple-sorbent 96-well method development plate. Optimized extraction conditions for up to five analytes are determined in a single 2.5-h experiment. The experiment can be tailored to determine SPE conditions (including wash protocols) for related analytes. Data obtained by liquid chromatography-atmospheric pressure ionization-mass spectrometry allows the quantitation of absolute recovery and selection of the best extraction conditions for approximately 100 analytes of diverse structure. Optimized extraction protocols yielding at least 80% recovery are determined for 81% of the analytes. For 96% of the analytes screened, extraction conditions resulting in recoveries of > or = 60% are determined. The most generic set of SPE conditions consist of either C8 or C18 sorbent with an eluent composition of acetonitrile with 5mM nitric acid added.  (+info)

High-performance liquid chromatographic determination of amphotericin B in a liposomal pharmaceutical product and validation of the assay. (6/350)

A validated high-performance liquid chromatographic method is presented to quantitate amphotericin B (AB) in a liposomal pharmaceutical formulation. The analysis is based on the chromatographic separation of AB and 1-amino-4-nitronaphthalene (the internal standard) on a C18 muBondapac reversed-phase column with a mobile phase consisting of a mixture of acetonitrile and 0.02 M ethylenediamine tetra-acetic acid disodium salt at pH 5.0 (45:55, v/v). The chromatographic analysis time is less than 10 min, and the validation of the assay shows that it is selective, accurate, and linear for the concentration range of 2.50 to 7.50 microg/mL with a detection limit of 0.00500 microg/mL. The within-day and between-day relative standard deviation values are 1.26% (n = 18) and 1.25% (n = 8), respectively. The method described conforms to the validation of compendial methods used for finished pharmaceutical products in general and offers a reliable, quick, and cost-effective procedure for examining the consistency or quality-control analysis of AB in liposomal products. It can also be applied for the determination of AB in other nonliposomal lipid-based drug delivery systems that are on the market.  (+info)

Simultaneous determination of sweeteners and preservatives in preserved fruits by micellar electrokinetic capillary chromatography. (7/350)

A micellar electrokinetic capillary method for the simultaneous determination of the sweeteners dulcin, aspartame, saccharin, and acesulfame-K and the preservatives sorbic acid; benzoic acid; sodium dehydroacetate; and methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutyl-p-hydroxybenzoate in preserved fruits is developed. These additives are ion-paired and extracted using sonication followed by solid-phase extraction from the sample. Separation is achieved using a 57-cm fused-silica capillary with a buffer comprised of 0.05 M sodium deoxycholate, 0.02 M borate-phosphate buffer (pH 8.6), and 5% acetonitrile, and the wavelength for detection is 214 nm. The average recovery rate for all sweeteners and preservatives is approximately 90% with good reproducibility, and the detection limits range from 10 to 25 microg/g. Fifty preserved fruit samples are analyzed for the content of sweeteners and preservatives. The sweeteners found in 28 samples was aspartame (0.17-11.59 g/kg) or saccharin (0.09-5.64 g/kg). Benzoic acid (0.02-1.72 g/kg) and sorbic acid (0.27-1.15 g/kg) were found as preservatives in 29 samples.  (+info)

Lactobacillus arizonensis sp. nov., isolated from jojoba meal. (8/350)

Five strains of simmondsin-degrading, lactic-acid-producing bacteria were isolated from fermented jojoba meal. These isolates were facultatively anaerobic, gram-positive, non-motile, non-spore-forming, homofermentative, rod-shaped organisms. They grew singly and in short chains, produced lactic acid but no gas from glucose, and did not exhibit catalase activity. Growth occurred at 15 and 45 degrees C. All strains fermented cellobiose, D-fructose, D-galactose, D-glucose, lactose, maltose, D-mannitol, D-mannose, melibiose, D-ribose, salicin, D-sorbitol, sucrose and trehalose. Some strains fermented L-(-)-arabinose and L-rhamnose. D-Xylose was not fermented and starch was not hydrolysed. The mean G+C content of the DNA was 48 mol%. Phylogenetic analyses of 16S rDNA established that the isolates were members of the genus Lactobacillus. DNA reassociation of 45% or less was obtained between the new isolates and the reference strains of species with G+C contents of about 48 mol%. The isolates were differentiated from other homofermentative Lactobacillus spp. on the basis of 16S rDNA sequence divergence, DNA relatedness, stereoisomerism of the lactic acid produced, growth temperature and carbohydrate fermentation. The data support the conclusion that these organisms represent strains of a new species, for which the name Lactobacillus arizonensis is proposed. The type strain of L. arizonensis is NRRL B-14768T (= DSM 13273T).  (+info)

Acetonitrile is an organic compound with the formula CH3CN. It is a colorless liquid that is used as a solvent and in the production of various chemicals. Acetonitrile is weakly basic and polar, and it has a unique smell that is often described as unpleasant or sweet.

Acetonitrile is not considered to be a medication or a drug, so it does not have a medical definition. However, it is sometimes used in the medical field as a solvent for various applications, such as in the preparation of pharmaceutical products or in laboratory research. It is important to handle acetonitrile with care, as it can be harmful if swallowed, inhaled, or contacted with the skin.

... was first prepared in 1847 by the French chemist Jean-Baptiste Dumas. Acetonitrile is used mainly as a solvent in ... For example, bis(acetonitrile)palladium dichloride is prepared by heating a suspension of palladium chloride in acetonitrile: ... Production trends for acetonitrile thus generally follow those of acrylonitrile. Acetonitrile can also be produced by many ... Acetonitrile, Geneva: World Health Organization Greenberg, Mark (1999), Toxicological Review of Acetonitrile (PDF), Washington ...
Vapor Pressures of Acetonitrile Determined by Comparative Ebulliometry, Michael B. Ewing* and Jesus C. Sanchez Ochoa, Journal ... This page provides supplementary chemical data on acetonitrile. The handling of this chemical may incur notable safety ...
... is an organoruthenium compound with the formula [(C5H5)Ru(NCCH3 ... The Synthesis and Reactions of a Synthetically Useful Intermediate: the Cyclopentadienyltris (acetonitrile) ruthenium (II) ... which is replaced by three equivalents of acetonitrile (MeCN): [Cp(C6H6)Ru]PF6 + 3 MeCN → [CpRu(NCMe)3]PF6 + C6H6 Gill, Thomas ...
... is the coordination complex with the formula PdCl2(NCCH3)2. It is the adduct of two ... Carretero, Juan Carlos; Arrayas, Ramon Gomez (2008). "Dichloro bis(acetonitrile) palladium". e-EROS Encyclopedia of Reagents ... acetonitrile ligands with palladium(II) chloride. It is a yellow-brown solid that is soluble in organic solvents. The compound ...
Black, J. R.; Levason, W.; Webster, M. (1995). "Tetrakis(acetonitrile-N)copper(I) Hexafluorophosphate(V) Acetonitrile Solvate ... Tetrakis(acetonitrile)copper(I) hexafluorophosphate is a salt with the formula [Cu(CH3CN)4]PF6. It is a colourless solid that ... The acetonitrile ligands protect the Cu+ ion from oxidation to Cu2+, but are rather poorly bound: with other counterions, the ... Dilution of acetonitrile solutions with water induces disproportionation: 2 [Cu(CH3CN)4]+ + 6 H2O → [Cu(H2O)6]2+ + Cu + 8 CH3CN ...
Acetonitrile, hydrogen cyanide and acrolein are known by-products. It is used in the preparation of homo- and copolymers, ... acetonitrile. There are two types of polymers that can be obtained at the end of the synthesis; a physisorbed polymer and a ...
From left to right: 1. water, 2. methanol, 3. ethanol, 4. acetonitrile, 5. dimethylformamide, 6. acetone, 7. ethyl acetate, 8. ...
The dye dissolves very well in water as well as other polar solvents, e.g., Dimethylformamide, acetonitrile. Texas Red, ...
For example, of the ligands acetonitrile, chloride ion and pyridine thepriority number assigned are chloride, 1; acetonitrile,2 ... If there are two possibilities the principle of trans difference is applied). As an example, (acetonitrile)dichlorido(pyridine) ... The ligand priority numbers are, applying the CIP rules: two chlorides of priority number 1 acetonitrile priority 2 pyridine ... acetonitrile)dichlorido(pyridine)platinum(II). The configuration index has two digits. The first digit is the priority number ...
I. Metal ions which have comparable polarographic properties in acetonitrile and in water." J. Am. Chem. Soc. 79 870-874. R. L ... I. M. Kolthoff and J. F. Coetzee (1957). "Polarography in acetonitrile. ...
Like other halogenated acetonitriles, trichloroacetonitrile is produced from organic substances such as algae, humic acids and ... Acetonitrile Trichloroacetic acid Chloral Pollak, Peter; Romeder, Gérard; Hagedorn, Ferdinand; Gelbke, Heinz-Peter. "Nitriles ... Trichloroacetonitrile can be obtained by chlorination of acetonitrile on a zinc, copper and alkaline earth metal halide- ... In contrast, the chlorination of acetonitrile saturated with hydrogen chloride leads to pure trichloroacetonitrile even at 50- ...
"Acetonitrile (EHC 154, 1993)". www.inchem.org. Archived from the original on 2017-05-22. Retrieved 2017-05-03. Akagah B, ... For example, phase I metabolism converts acetonitrile to HOCH2CN, which rapidly dissociates into formaldehyde and hydrogen ...
... diethyl ether and acetonitrile. According to X-ray crystallography, the compound adopts a helical chain structure featuring ...
In acetonitrile its pKa is 24.31. The base is prepared by the reaction of tert-butylamine with a Vilsmeier salt. The latter is ...
Bühl, Michael; Sieffert, Nicolas; Chaumont, Alain; Wipff, Georges (2011-01-03). "Water versus Acetonitrile Coordination to ...
It is freely soluble in water; it is not soluble in acetonitrile. In a dilute aqueous solution, potassium bromide tastes sweet ...
ISBN 978-0-470-13233-3. Richard R. Thomas; Ayusman Sen (1990). "Acetonitrile Complexes of Selected Transition Metal Cations". ...
"Basicity of Phosphanes and Diphosphanes in Acetonitrile". European Journal of Organic Chemistry. 2012 (11): 2167-2172. doi: ...
LiGaH4 reduces acetamide and acetonitrile to ethylamine. Aliphatic acids, aldehydes and ketones are reduced to the ...
Acetonitrile solutions cleave acetals and some ethers. Many reactive cations have been obtained using fluoroboric acid, e.g. ... Heintz, R. A.; Smith, J. A.; Szalay, P. S.; Weisgerber, A.; Dunbar, K. R. (2002). Homoleptic Transition Metal Acetonitrile ... Titration of [N((CH2)3CH3)4]+[BF4]− (tetrabutylammonium tetrafluoroborate) in acetonitrile solution indicates that H[BF4], i.e ...
Global seasonal distributions of HCN and acetonitrile. 2019. 99th AMS Annual Meeting, American Meteorological Society (AMS). ... "Global seasonal distributions of HCN and acetonitrile". {{cite journal}}: Cite journal requires ,journal= (help) Barth, Mary C ...
... sparingly soluble in isopropyl alcohol and acetonitrile; slightly soluble in diethyl ether; and very slightly soluble in ...
An adduct is also formed with acetonitrile. Dove, Michael F. A.; Berthold Manz; John Montgomery; Gerald Pattenden; Simon A. ...
Hexakis(acetonitrile)rhodium(III) tetrafluoroborate ([Rh(MeCN)6](BF4)3), a yellow solid. Hexakis(acetonitrile)rhenium(II) ... Hexakis(acetonitrile)vanadium(II) tetrachlorozincate ([V(MeCN)6](ZnCl4)), green Hexakis(acetonitrile)chromium(II) bis( ... acetonitrile)iron(II) bis(tetrakis(pentafluorophenyl)borate) ([Fe(MeCN)6](B(C6F5)4)2, orange Hexakis(acetonitrile)cobalt(II) ... acetonitrile) Tris(pyrazolyl)borate, and Tris(acetonitrile) Tris(pyrazolyl)methane Ruthenium(II) Complexes". Inorganica Chimica ...
Frequently, tetrakis(acetonitrile)copper(I) salts are used. For most applications, reactions can be run at room temperature and ... The reaction is conducted in acetonitrile at room temperature under an atmosphere of air, or less commonly, under an atmosphere ... The reaction is conducted in acetonitrile at room temperature under an atmosphere or air. Catalyst loadings are typically ... The system utilizes 2,2'-bipyridine (bpy), a copper(I) source (typically tetrakis(acetonitrile) copper(I) triflate, ...
The reported pKa in acetonitrile (MeCN) is −3.7. The pKa in DMSO was estimated by the correlation pKaMeCN = 0.98 × pKaDMSO + ...
The complex PaCl4·4CH3CN is formed with acetonitrile. It has a tetragonal crystal structure with the space group I41/amd (space ...
Kaupmees, K.; Kaljurand, I.; Leito, I. (2014). "Influence of Water Content on Basicities in Acetonitrile". J. Solut. Chem. 43 ( ... "Influence of Water Content on the Acidities in Acetonitrile. Quantifying Charge Delocalization in Anions". J. Phys. Chem. A. ...
First, the acetonitrile is oxidized, forming an imine hydroperoxide. Then, this intermediate oxidizes the aniline to ... in acetonitrile at 50 °C. In this reaction, the pH should be kept around 8, to activate the hydrogen peroxide and avoid too ...
Solvents include trifluoroacetic acid, methanol, dichloromethane, chloroform, and acetonitrile. Many derivatives of ...
Acetonitrile was first prepared in 1847 by the French chemist Jean-Baptiste Dumas. Acetonitrile is used mainly as a solvent in ... For example, bis(acetonitrile)palladium dichloride is prepared by heating a suspension of palladium chloride in acetonitrile: ... Production trends for acetonitrile thus generally follow those of acrylonitrile. Acetonitrile can also be produced by many ... Acetonitrile, Geneva: World Health Organization Greenberg, Mark (1999), Toxicological Review of Acetonitrile (PDF), Washington ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
3-Acetylphenyl)acetonitrile , C10H9NO , CID 45086166 - structure, chemical names, physical and chemical properties, ...
This page contains information on the chemical Acetonitrile including: 20 synonyms/identifiers; U.S. Code of Federal ... Acetonitrile. Identifications. *Formula: C2H3N*Formula: CH3CN. Elements: Carbon, Hydrogen, Nitrogen. *CAS Number: 75-05-8*RCRA ... Acetonitrile (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Acetonitrile including: 20 ... Acetonitrile. No. No. 1648. 127. Methyl cyanide. No. No. Related Resources. *USDOT Hazardous Materials Table 49 CFR 172.101. An ...
Shop Greenfield Global Acetonitrile at Thomas Scientific, your trusted partner in Science. Ready to Ship. ... Acetonitrile. * PRODUCT AVAILABILITY: Did you know you can view a products availability right on the product page? Simply ... The Greenfield Global HPLC grade acetonitrile is suitable for use in research facilities and chemical laboratories to conduct ...
Acetonitrile,Methyl Cyanide, Ethanenitrile,ACN,Cyanomethane,Ethyl nitrile,Methyl cyanide; Linear Formula: CH3CN; find Supelco- ... Acetonitrile Non UV for GC OmniSolv®; CAS Number: 75-05-8; Synonyms: ...
Isofenphos solution 100 μg/mL in acetonitrile, PESTANAL®, analytical standard; CAS Number: 25311-71-1; Synonyms: 2-(Ethoxy- ...
Master bond tests and evaluates many different adhesives for chemical resistance to acetonitrile. ... Acetonitrile Resistant Adhesives. EP41S-5LV. Excellent chemical resistance to solvents, alcohols, fuels, acids and bases. Low ... Testing Adhesives for Resistance to Acetonitrile. Many Master Bond epoxy systems are formulated with superior chemical ... As can be seen in the graphs, the standard epoxy was markedly less resistant to acetonitrile than the other epoxies tested. It ...
Receive supply/demand analysis of current markets for Acetonitrile, future growth with five-year projections, and historical ... World acetonitrile consumption has continued to grow at an average annual rate of 5%-6% over the last five years, thanks to the ... Acetonitrile is used as a starting material to synthesize vitamins A and B1, cortisone, carbonate drugs and some amino acids. ... The use of acetonitrile in pharmaceutical products has grown rapidly in recent years, boosted by improved living standards in ...
BR725 Activator Reagent (Honeywell Burdick & Jackson) CAS Number: 75-05-8 . Shop Honeywell Burdick & Jackson™ Activator Reagent, 0.5M ETT in Acetonitrile at
Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution ... Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution. *PDB DOI: https://doi. ...
Thermo Scientific Acetonitrile (ACN) is an LC/MS-grade preparation with high purity and low UV-absorptivity that makes it ...
Comprehensive supplier list for Acetonitrile, 2-(4-hydroxyphenoxy)-,Acetonitrile, 2-(4-iodophenoxy)- ... Acetonitrile, 2-(butylamino)- (0 suppliers). 3101-04-6. Acetonitrile, 2-(cyclobutylamino)- (0 suppliers). IUPAC Name: 2-( ... Acetonitrile, 2-(dicyclohexylamino)- (0 suppliers). 874006-22-1. Acetonitrile, 2-(diphenylamino)- (0 suppliers). IUPAC Name: 2 ... Acetonitrile, 2-(4-iodophenoxy)- (6 suppliers). IUPAC Name: 2-(4-iodophenoxy)acetonitrile , CAS Registry Number: 243657-95-6. ...
Methanol and acetonitrile have different chemical properties. Methanol is a protic solvent, whereas acetonitrile is a non- ... It can be seen that when acetonitrile and methanol are mixed with water in the same ratio, an acetonitrile mobile phase ... 2 that the absorbance of HPLC-grade acetonitrile is particularly low at short wavelengths. This HPLC-grade acetonitrile is ... Acetonitrile (CH3-C≡N) has a triple C-N bond and therefore π electrons, whereas methanol (CH3-OH) has no π electrons. For a ...
Shop BiopureTM Aflatoxins in acetonitrile now! Lets make the Worlds Food safer together. ... Acetonitrile. Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2, 100 ng/mL each. ...
These two mixed solutions, water-acetonitrile and acetonitrile-ethyl acetate, were individually fed into two separate ... ① the water-acetonitrile-ethyl acetate mixed solution (15:3.2:1.8 volume ratio), ② the water-acetonitrile-ethyl acetate mixed ... the water-acetonitrile-ethyl acetate mixed solution (3.8:11.8:5.2 volume ratio), ② the water-acetonitrile-ethyl acetate mixed ... the water-acetonitrile-ethyl acetate ternary mixed solution (15:3:2, volume ratio; water-rich), and (D) the water-acetonitrile- ...
Acetonitrile with trifluoroacetic acid (0.1%), HPLC Grade, Fisher Chemical at Fishersci.com ... Mobile phase for HPLC, Acetonitrile with trifluoroacetic acid (0.1%), HPLC Grade, Fisher Chemical ... methyl cyanide, cyanomethane, ethanenitrile, methanecarbonitrile, ethyl nitrile, methane, cyano, acetonitrile, cyanure de ... methyl cyanide, cyanomethane, ethanenitrile, methanecarbonitrile, ethyl nitrile, methane, cyano, acetonitrile, cyanure de ...
Lithium Tricyanomethanide - Acetonitrile Complex
CIL) offers product CLM-4546-1-2 Acetochlor (ring-¹³C₆, 99%) 100 µg/mL in acetonitrile ... Acetochlor (unlabeled) 100 µg/mL in acetonitrile. Item No.ULM-9824-1.2 ... Acetochlor (unlabeled) 100 µg/mL in acetonitrile. Item No.ULM-9824-1.2 ...
Poly[[bis--(aceto-nitrile-κN)bis--[μ2-2,2′-(methyl-enedi-thio)bis--(1,3,4-thia-diazole)-κ2N4:N4′]copper(II)] bis--(perchlorate ... Poly[[bis(acetonitrile-κN)bis[µ2-2,2-(methylenedithio)bis(1,3,4- thiadiazole)-κ2N4:N4]copper(II)] bis(perchlorate) ... one coordinated acetonitrile molecule, one uncoordinated acetonitrile molecule, and one perchlorate ion (Fig. 1). The CuII atom ... The reaction of 2,2-(methylenedithio)bis(1,3,4-thiadiazole) (0.2 mmol) with Cu(ClO4)2 (0.1 mmol) in an acetonitrile solution ( ...
The CPT Codes provided in this document are based on AMA Guidelines and are for informational purposes only. NMS Labs Does not assume responsibility for billing errors due to Reliance on the CPT Codes listed in this document.. *The information contained in this document represents database configurations, as they will appear on the effective date listed above. ...
... カタログ番号 33267 ... QuEChERS Internal Standard Mix for GC/MS Analysis, in Acetonitrile, 5 mL/ampul. ...
The North America acetonitrile market is driven by the rapid growth in the automotive industry, surging demand for patent ... finds that the North America acetonitrile market size reached 27,191 Tons in 2022. Acetonitrile, also known as methyl cyanide ... North America Acetonitrile Market to Reach 35,006 Tons by 2028, Spurred by Rapid Growth in the Automotive Industry February 06 ... North America Acetonitrile Market Trends: In North America, rapid growth in the automotive industry coupled with the escalating ...
Binding affinity to Mg2+ ion in acetonitrile assessed as induction of shift in the maximum absorbance wavelength at 25 uM by UV ...
4-methoxyphenyl)acetonitrile - cas 104-47-2, synthesis, structure, density, melting point, boiling point ... Tags: melting point of (4-methoxyphenyl)acetonitrile - 104-47-2 , boiling point of (4-methoxyphenyl)acetonitrile - 104-47-2 , ... density of (4-methoxyphenyl)acetonitrile - 104-47-2 , refractive index of (4-methoxyphenyl)acetonitrile - 104-47-2 ...
In the 1:1 solvate (II), the acetonitrile mol. forms short N-HN contacts (NN , 3.2 .ANG.) between the solvent N atoms and one ... In the 1:1 solvate (II), the acetonitrile mol. forms short N-HN contacts (NN , 3.2 .ANG.) between the solvent N atoms and one ... Bis(glycinato-kappa2N,O)dinitrosylmolybdenum(0) and bis(2-aminoethanethiolato-kappa2N,S)dinitrosylmolybdenum(0) acetonitrile ... acetonitrile monosolvate. Acta Crystallographica. Section C, Crystal Structure Communications, 64(2):M87-M90. ...
6-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetonitrile - C14H14N2O, synthesis, structure, density, melting point, ... acetonitrile , density of (6-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetonitrile , refractive index of (6-oxo-1,2 ... Tags: melting point of (6-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetonitrile , boiling point of (6-oxo-1,2,4,5,6 ...
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Calibrant containing Aflatoxin B1 at a concentration of 25μg/mL in Acetonitrile and packaged in 10mL volume. Liquid: Ready-to- ... Solvent: Acetonitrile. Volume: 10 mL. Vial: Chemically-treated amber borosilicate glass vial.. Storage: Product must be stored ... Calibrant containing Aflatoxin B1 at a concentration of 25μg/mL in Acetonitrile and packaged in 10mL volume. ... ":"25µg\/mL Aflatoxin B1 in acetonitrile - In situ","public_title":"In situ","options":["In situ"],"price":16400,"weight":227," ...
  • Acetonitrile, often abbreviated MeCN (methyl cyanide), is the chemical compound with the formula CH3CN and structure H3C−C≡N. This colourless liquid is the simplest organic nitrile (hydrogen cyanide is a simpler nitrile, but the cyanide anion is not classed as organic). (wikipedia.org)
  • Acetonitrile, also known as methyl cyanide and ethanenitrile, refers to a highly volatile, flammable, and toxic solvent with the chemical formula CH 3 CN. (imarcgroup.com)
  • The Gibbs energies of transfer are accounted for in terms of hydrogen - hydrogen interactions between the methyl group of acetonitrile and the hydrogen atoms of the ligands of the studied complexes. (uni-linz.ac.at)
  • Acetonitrile is used mainly as a solvent in the purification of butadiene in refineries. (wikipedia.org)
  • Acetonitrile plays a significant role as the dominant solvent used in oligonucleotide synthesis from nucleoside phosphoramidites. (wikipedia.org)
  • The pharmaceutical industry is the largest end use for acetonitrile, which uses it as a reagent, reaction solvent or extraction solvent. (spglobal.com)
  • Moreover, acetonitrile is also used as a solvent in the production of insulin and antibiotics, including third-generation cephalosporins. (spglobal.com)
  • Acetonitrile is also used as a solvent in UV spectroscopy and polarography. (spglobal.com)
  • Fig. 1 shows an example of the solvent ratio and solvent delivery pressure for mixtures of water/acetonitrile and water/methanol. (shimadzu.com)
  • Figs. 2 and 3 show the absorption spectra of acetonitrile and methanol, including both commercial-grade solvent for HPLC use and high-grade solvent. (shimadzu.com)
  • When changing the organic solvent from acetonitrile to methanol, ghost peaks may be detected in gradient analysis due to the analytical conditions in the UV short wavelength range. (shimadzu.com)
  • The nomogram in Fig. 5 shows the ratios of methanol and acetonitrile to water with equivalent solvent strength, useful for approximate calculation of elution strength when changing between these solvents. (shimadzu.com)
  • Methanol is a protic solvent, whereas acetonitrile is a non-protic solvent, so we know that their elution behavior will differ. (shimadzu.com)
  • Eosin Y as a model fluorescence compound was dissolved with the ternary solutions of water (1.0 mM carbonate buffer, pH 9.0)-acetonitrile-ethyl acetate, water-rich of 15:3:2 volume ratio and organic solvent-rich of 3:8:4 volume ratio, to which bis(2,4,6-trichlorophenyl) oxalate and hydrogen peroxide chemiluminescence reagent were added. (scirp.org)
  • The chemiluminescence observed with the ternary solutions, especially the organic solvent-rich solution, showed a larger signal than that observed with the water only solution or water-acetonitrile mixed solution. (scirp.org)
  • In our previous study, we examined luminal chemiluminescence (CL) behavior in a ternary mixed solvent solution of water-acetonitrile-ethyl acetate, and the mixed solution was found to enhance luminol CL in time and intensity under certain conditions [12]. (scirp.org)
  • In addition, the rising applications of aqueous acetonitrile as an extraction solvent in the agriculture industry have accelerated product adoption rates. (imarcgroup.com)
  • Acetonitrile is used as a solvent in the manufacture of pharmaceuticals. (biesterfeld.com)
  • The second-largest use of acetonitrile is as a mobile phase in high-performance liquid chromatography (HPLC). (spglobal.com)
  • Our premium quality Acetonitrile LC/MS grade is highly recommended for high performance liquid chromatography ( LC/MS ) systems. (laballey.com)
  • With a dipole moment of 3.92 D, acetonitrile dissolves a wide range of ionic and nonpolar compounds and is useful as a mobile phase in HPLC and LC-MS. It is widely used in battery applications because of its relatively high dielectric constant and ability to dissolve electrolytes. (wikipedia.org)
  • Fig. 7 shows an example of separation by methanol or acetonitrile of compounds in which one hydrogen atom of a benzene ring is substituted with a carboxyl group or a hydroxyl group. (shimadzu.com)
  • Methanol and acetonitrile are organic acids commonly used as the mobile phase in reverse-phase chromatography. (shimadzu.com)
  • The properties of these two organic acids differ, and below we outline 7 key differences to keep in mind when using methanol or acetonitrile for analysis. (shimadzu.com)
  • Setting the column temperature between 25-40 oC and comparing the column pressures for water/acetonitrile and water/methanol, we can see that the pressure is higher for methanol. (shimadzu.com)
  • When switching the mobile phase from acetonitrile to methanol, the pressure resistance of the equipment and column should be rechecked. (shimadzu.com)
  • It can be seen that when acetonitrile and methanol are mixed with water in the same ratio, an acetonitrile mobile phase displays greater elution strength. (shimadzu.com)
  • If we have previously been using acetonitrile as the mobile phase with a ratio to water of 50/50 (v/v), when changing to methanol the equivalent ratio of methanol/water would be 60/40 (v/v). (shimadzu.com)
  • The separation selectivity of acetonitrile and methanol differ, but since selectivity depends on the properties of the dissolved compound, it is not the case that selectivity is always higher for one or the other. (shimadzu.com)
  • Acetonitrile (CH3-C≡N) has a triple C-N bond and therefore π electrons, whereas methanol (CH3-OH) has no π electrons. (shimadzu.com)
  • Methanol and acetonitrile have different chemical properties. (shimadzu.com)
  • If adequate separation cannot be obtained with an acetonitrile-based mobile phase, switching to a methanol-based mobile phase to change the elution order is one useful possibility for method development. (shimadzu.com)
  • Compared to methanol, acetonitrile reacts endothermically with water and exhibits a higher elution strength. (imarcgroup.com)
  • Onset of symptoms after exposure to nitriles (acetonitrile and/or propionitrile) may be significantly delayed. (medscape.com)
  • The Greenfield Global HPLC grade acetonitrile is suitable for use in research facilities and chemical laboratories to conduct wide range of experiments. (thomassci.com)
  • It can be seen from Fig. 2 that the absorbance of HPLC-grade acetonitrile is particularly low at short wavelengths. (shimadzu.com)
  • This HPLC-grade acetonitrile is therefore suited to high-sensitivity analysis with UV detection in the short-wavelength region. (shimadzu.com)
  • Acetonitrile is a byproduct from the manufacture of acrylonitrile. (wikipedia.org)
  • Production trends for acetonitrile thus generally follow those of acrylonitrile. (wikipedia.org)
  • Acetonitrile is a byproduct in the production of acrylonitrile and its production also decreased, further compounding the acetonitrile shortage. (wikipedia.org)
  • The current acetonitrile supply situation is rather tight because of production losses resulting from weak demand for the coproduct acrylonitrile. (spglobal.com)
  • This can be attributed to the surging adoption of acetonitrile in producing acrylonitrile butadiene styrene (ABS) plastic that offers high tensile and impact strength and optimal chemical resistance. (imarcgroup.com)
  • Generally the onset of toxic effects is delayed, due to the time required for the body to metabolize acetonitrile to cyanide (generally about 2-12 hours). (wikipedia.org)
  • Cases of acetonitrile poisoning in humans (or, to be more specific, of cyanide poisoning after exposure to acetonitrile) are rare but not unknown, by inhalation, ingestion and (possibly) by skin absorption. (wikipedia.org)
  • In this study, we examined CL behavior with four kinds of mixed solutions of water only, water-acetonitrile, and ternary mixed solutions of water-acetonitrile-ethyl acetate for peroxyoxalate reagent, instead of luminol reagent [13] [14], in the presence of Eosin Y as a model fluorescence compound. (scirp.org)
  • These two mixed solutions, water-acetonitrile and acetonitrile-ethyl acetate, were individually fed into two separate microchannels of a microchip that combined to form a single channel in a Y-type microchannel, affording a ternary mixed solution in the single channel. (scirp.org)
  • Extraction with acetonitrile/water did not significantly affect the amount of extractable substance, though extraction with acetonitrile/HCL under reflux conditions did increase the amount of extractable substance, however this is not considered environmentally relevant. (janusinfo.se)
  • The acetonitrile extraction eliminates the need for chromatographic purification of vitamin D prior to its actual assay. (medscape.com)
  • For longer term exposure to acetonitrile over a year or longer, the likes of EP41S-5 and EP62-1HT are excellent candidates. (masterbond.com)
  • The mouse LC50 value of 2,693 ppm for a 60 minute exposure to acetonitrile [Willhite 1981] was selected as the basis for the IDLH value. (cdc.gov)
  • Please note, when choosing an epoxy for an application where the resistance to acetonitrile is critical, many other factors must be considered in addition to the chemical resistance. (masterbond.com)
  • These products all need to be processed or cured differently and although some of them can be cured with UV light or at room temperature alone, for enhancing/optimizing chemical resistance especially to acetonitrile, it is critical to add heat. (masterbond.com)
  • S&P Global's Chemical Economics Handbook - Acetonitrile is the comprehensive and trusted guide for anyone seeking information on this industry. (spglobal.com)
  • S&P Global's Chemical Economics Handbook - Acetonitrile has been compiled using primary interviews with key suppliers and organizations, and leading representatives from the industry in combination with S&P Global's unparalleled access to upstream and downstream market intelligence and expert insights into industry dynamics, trade and economics. (spglobal.com)
  • For use on containers that store Acetonitrile to ensure the workplace is aware of the immediate chemical hazards that are present. (hclco.com)
  • Chemical degradation in acetonitrile and urine was monitored over 250 days. (cdc.gov)
  • In line with this, the increasing adoption of acetonitrile in producing acrylic fibers and plastics and casting and molding plastic materials has propelled the market growth. (imarcgroup.com)
  • [ 10 ] In general, these assays depend on an antibody that recognizes 25(OH)D2 and 25(OH)D3 in equimolar proportions and the competitive displacement of tracer 25(OH)D (25(OH)D that has been tagged with a radioactive isotope such as 125-I or a chemiluminescent ligand) by acetonitrile extracted samples. (medscape.com)
  • The Gibbs energies of transfer, DtGo, for [Co(bipy)3]3+ and [Co(bipy)3]2+ in the full range of acetonitrile - water mixtures were derived from solubility measurements of the picrates and partitioned into single-ion contributions based on the tetraphenylarsonium tetraphenylborate assumption. (uni-linz.ac.at)
  • In addition polarography, cyclic voltammetry and uv-visible spectroscopy were also performed on these complexes in water - acetonitrile mixtures. (uni-linz.ac.at)
  • The interpretations of TDtSo-values and the enthalpies of transfer was based on different regions for the structure of acetonitrile - water mixtures and on the possibility of the Co-bipy cations entering cavities in the water structure of water-rich mixtures. (uni-linz.ac.at)
  • Studies on cobalt-tris(bipyridyl) complexes in acetonitrile - water mixtures, Jan Benko, Ol'ga Vollarova and Gerhard Gritzner, Phys. (uni-linz.ac.at)
  • Acetonitrile is a common two-carbon building block in organic synthesis of many useful chemicals, including acetamidine hydrochloride, thiamine, and α-napthaleneacetic acid. (wikipedia.org)
  • The asymmetric unit of the title compound consists of half a Cu II atom, two independent 2,2'-(methylenedithio)bis(1,3,4-thiadiazole) ( L ) ligands, one coordinated acetonitrile molecule, one uncoordinated acetonitrile molecule, and one perchlorate ion (Fig. 1). (iucr.org)
  • The Cu II atom is coordinated by six N atoms, from four L ligands and two acetonitrile molecules, in a slightly distorted octahedral geometry. (iucr.org)
  • In 1992[update], 14,700 tonnes (16,200 short tons) of acetonitrile were produced in the US. (wikipedia.org)
  • The unprecedented, fully deprotonated form of acetonitrile, the acetonitriletriide anion CCN3−, is experimentally realized for the first time in the stabilizing bulk host framework of the Ba5[TaN4][C2N] nitridometalate via a one-pot synthesis from the elements under moderate conditions (920 K). The molecular structure of this long-sought acetonitrile derivative is confirmed by X-ray diffraction, as well as NMR, IR, and Raman spectroscopy. (mpg.de)
  • Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3. (ntu.edu.sg)
  • Acetonitrile is used as a starting material to synthesize vitamins A and B1, cortisone, carbonate drugs and some amino acids. (spglobal.com)
  • Before analysis, the and sonicated with 60 mL of 0.1 N NaOH filtrate was diluted with water/acetonitrile (ultrasonic bath) for 10 minutes. (who.int)
  • For a water:acetonitrile mobile phase, the minor disturbance method using deuterated acetonitrile to obtain an integral average void volume (2.08 and 2.05 mL for C18 at 30 and 40 °C, respectively and 2.16 and 2.13 mL for C8 at 30 and 40 °C, respectively) was found to be the most appropriate method for determining the elusive column void volume. (lu.se)
  • Specifically, acetonitrile is fed into the top of a distillation column filled with hydrocarbons including butadiene, and as the acetonitrile falls down through the column, it absorbs the butadiene which is then sent from the bottom of the tower to a second separating tower. (wikipedia.org)
  • It demonstrated a significantly greater change in weight over time, and the casting ultimately dissolved in acetonitrile after nearly one year. (masterbond.com)
  • Acetonitrile is an aliphatic nitrile with a pleasant odor and colorless liquid appearance when stored at room temperature. (laballey.com)
  • World acetonitrile consumption has continued to grow at an average annual rate of 5%-6% over the last five years, thanks to the increasing production of engineered drugs, generic pharmaceuticals and pesticides. (spglobal.com)
  • Consumption of acetonitrile for pharmaceuticals will continue to grow during the next five years. (spglobal.com)
  • Calibrant containing Aflatoxin B1 at a concentration of 25μg/mL in Acetonitrile and packaged in 10mL volume. (trilogylab.com)
  • An uncertainty factor of 30 was applied to account for extrapolation from a concentration that is lethal to animals, animal to human differences, and human variability, resulting in an IDLH value for acetonitrile of 137 ppm. (cdc.gov)
  • IMARC Group's latest report, titled "North America Acetonitrile Market: Industry Trends, Share, Size, Growth, Opportunity and Forecast 2023-2028," finds that the North America acetonitrile market size reached 27,191 Tons in 2022. (imarcgroup.com)
  • In this experiment, we focused on testing our epoxies for their resistance to acetonitrile. (masterbond.com)
  • By utilizing a three-way ANOVA, the composition of the mobile phase has been shown to have a significant effect on deuterated acetonitrile and other investigated void volume markers, demonstrating the fact that both void volume markers and acetonitrile itself exhibit retention-like behaviour. (lu.se)
  • The comparison of void volumes, obtained with conventional neutral void volume markers, revealed the former to be 24-36% lower than the void volume obtained using deuterated acetonitrile, as an isotopically labelled mobile phase component. (lu.se)
  • Besides this, the growing utilization of acetonitrile to extract oleochemicals, such as fatty acids from animal and vegetable oils in laboratories, has augmented the product demand. (imarcgroup.com)
  • The global shortage of acetonitrile continued through early 2009. (wikipedia.org)