Dictionaries, ChemicalAgrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Biopharmaceutics: The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Acetonitriles: Compounds in which a methyl group is attached to the cyano moiety.Biological Ontologies: Structured vocabularies describing concepts from the fields of biology and relationships between concepts.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Intermittent Positive-Pressure Breathing: Application of positive pressure to the inspiratory phase of spontaneous respiration.Chemical Hazard Release: Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.Respiratory Protective Devices: Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.National Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Positive-Pressure Respiration: A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.Intermittent Positive-Pressure Ventilation: Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Masks: Devices that cover the nose and mouth to maintain aseptic conditions or to administer inhaled anesthetics or other gases. (UMDNS, 1999)Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)Pharmacopoeias as Topic: Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Musculoskeletal Diseases: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.Distillation: A chemical process for separating the components of a liquid mixture by boiling and collecting condensed vapors.Atmospheric Pressure: The pressure at any point in an atmosphere due solely to the weight of the atmospheric gases above the point concerned.Steam: Water in its gaseous state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Plasma Gases: Ionized gases, consisting of free electrons and ionized atoms or molecules which collectively behave differently than gas, solid, or liquid. Plasma gases are used in biomedical fields in surface modification; biological decontamination; dentistry (e.g., PLASMA ARC DENTAL CURING LIGHTS); and in other treatments (e.g., ARGON PLASMA COAGULATION).
(1/350) Efficient nitroso group transfer from N-nitrosoindoles to nucleotides and 2'-deoxyguanosine at physiological pH. A new pathway for N-nitrosocompounds to exert genotoxicity.

The endogenous formation of N-nitrosoindoles is of concern since humans are exposed to a variety of naturally occurring and synthetic indolic compounds. As part of a study to evaluate the genotoxicity of N-nitrosoindoles, the reactions of three model compounds with purine nucleotides and 2'-deoxyguanosine at physiological pH were investigated. The profiles of reaction products were identical for each of the N-nitrosoindoles and three distinct pathways of reaction could be discerned. These pathways were: (i) depurination to the corresponding purine bases, (ii) deamination, coupled with depurination, to give hypoxanthine and xanthine, and (iii) formation of the novel nucleotide 2'-deoxyoxanosine monophosphate and its corresponding depurination product oxanine in reactions with 2'-deoxyguanosine monophosphate. 2'-Deoxyoxanosine and oxanine were observed in reactions with 2'-deoxyguanosine. Further studies showed that formation of all of these products could be rationalized by an initial transnitrosation step. These results suggest that, in contrast to many other genotoxic N-nitrosocompounds which are known to alkylate DNA, the genotoxicity of N-nitrosoindoles is likely to arise through transfer of the nitroso group to nucleophilic sites on the purine bases. All of the products resulting from transnitrosation by N-nitrosoindoles are potentially mutagenic. These findings reveal a new pathway for N-nitrosocompounds to exert genotoxicity.  (+info)

(2/350) Studies of structure and mechanism in acetonitrile chemical ionization tandem mass spectrometry of polyunsaturated fatty acid methyl esters.

Recently it has been shown that acetonitrile chemical ionization tandem mass spectrometry (CI-MS/MS) is a rapid, on-line means to determine double bond position in fatty acid methyl esters (FAME). The mechanism of this gas phase condensation reaction has been studied. Evidence of the (1-methyleneimino)-1-ethenylium ion (m/z 54), formed upon the reaction of acetonitrile with itself, adding across the double bond in a [2 + 2] cycloaddition reaction is observed. When this nascent complex undergoes collision-induced dissociation, two diagnostic ions emerge. One of these ions results from loss of the hydrocarbon end of the FAME, whereas the other ion results from loss of the methyl ester end, and when considered together, the diagnostic ions localize the positions of the double bonds in the FAME. Several labeling and MS/MS/MS experiments on the two diagnostic ions were performed to determine a plausible fragmentation mechanism of the stable (1-methyleneimino)-1-ethenylium-FAME complex. The first generation product ions, or diagnostic ions, appear to be formed though a charge-driven mechanism, whereas the second generation product ions are formed via charge-remote fragmentations. Plausible mechanisms for the formation and subsequent dissociation of the diagnostic ions are presented for the monounsaturated, diunsaturated, and polyunsaturated (3 or more double bonds) FAME.  (+info)

(3/350) Stimulation of tolbutamide hydroxylation by acetone and acetonitrile in human liver microsomes and in a cytochrome P-450 2C9-reconstituted system.

Organic solvents are often used to solubilize lipophilic new chemical entities before their addition to in vitro test systems such as microsomal stability or cytochrome P-450 (CYP) inhibition. However, the effect of these organic solvents on the test systems is not usually characterized. This study was initiated to evaluate the effect of acetonitrile and acetone, in addition to other organic solvents, on the tolbutamide hydroxylation activity of CYP2C9 in both human liver microsomes and a CYP2C9-reconstituted system. Both acetonitrile and acetone significantly stimulated the NADPH-dependent tolbutamide hydroxylation by nearly 2- to 3-fold in human liver microsomes and CYP2C9-reconstituted system when incubated at 2 and 4% final solvent concentrations. When cumene hydroperoxide was used instead of NADPH, both acetone and acetonitrile significantly inhibited tolbutamide hydroxylation. This NADPH-dependent stimulatory effect was further evaluated by examining the effect of a series of other organic solvents with different carbon chain lengths and various functional groups, including hydroxyl, ketone, and aldehyde. Unlike acetone, two other ketone-containing solvents, methyl ethyl ketone (2-butanone) and diethyl ketone (3-pentanone) failed to significantly enhance tolbutamide hydroxylation. Other solvents tested, including methanol, ethanol, propanol, 1-butanol, 2-butanol, 1-pentanol, 2-pentanol, acetaldehyde, and dimethyl sulfoxide significantly inhibited NADPH-dependent tolbutamide hydroxylation. Overall, the stimulatory effect of both acetonitrile and acetone on tolbutamide hydroxylation was found to be primarily due to a consistent increase in V(max), whereas K(m) was unchanged in both human liver microsomes and the reconstituted CYP2C9 system. These data suggest that acetone and acetonitrile stimulate NADPH-mediated tolbutamide hydroxylation via the CYP reductase and not by modifying the affinity of tolbutamide for the CYP2C9 enzyme.  (+info)

(4/350) Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity.

Acetonitrile is an organic solvent commonly used to increase the solubility of lipophilic substrates for in vitro studies. In this study, we examined its effect on four reactions (diclofenac hydroxylation, tolbutamide methyl hydroxylation, phenytoin hydroxylation, and celecoxib methyl hydroxylation) catalyzed by human liver microsomes and by the recombinant CYP2C9. In both cases, the effect of acetonitrile on activity was found to be substrate-dependent. Namely, it increased diclofenac 4'-hydroxylase and tolbutamide methyl hydroxylase activities, but decreased celecoxib methyl hydroxylase activity in a concentration-dependent manner. By comparison, hydroxylation of phenytoin was resistant to its effect. The presence of acetonitrile (3%, v/v) gave rise to a lower K(m) and a higher V(max) for diclofenac hydroxylase in both liver microsomes and recombinant CYP2C9 preparations (87 and 52% increase in V(max)/K(m) ratio, respectively). On the other hand, the inhibitory effect of the solvent (1%, v/v) toward celecoxib hydroxylase was characterized by a decrease in V(max) (human liver microsomes) or a change in both K(m) and V(max) (rCYP2C9), leading to 25 and 46% decrease in V(max)/K(m) for both systems. The results of this study underscore the need for careful evaluation of solvent effects before initiation of inhibition or cytochrome P450 reaction phenotyping studies.  (+info)

(5/350) High-throughput method development approaches for bioanalytical mass spectrometry.

A rational approach to the development and optimization of solid-phase extraction (SPE) methods is described. The semiautomated scheme allows for the simultaneous testing of multiple chemistries using a custom multiple-sorbent 96-well method development plate. Optimized extraction conditions for up to five analytes are determined in a single 2.5-h experiment. The experiment can be tailored to determine SPE conditions (including wash protocols) for related analytes. Data obtained by liquid chromatography-atmospheric pressure ionization-mass spectrometry allows the quantitation of absolute recovery and selection of the best extraction conditions for approximately 100 analytes of diverse structure. Optimized extraction protocols yielding at least 80% recovery are determined for 81% of the analytes. For 96% of the analytes screened, extraction conditions resulting in recoveries of > or = 60% are determined. The most generic set of SPE conditions consist of either C8 or C18 sorbent with an eluent composition of acetonitrile with 5mM nitric acid added.  (+info)

(6/350) High-performance liquid chromatographic determination of amphotericin B in a liposomal pharmaceutical product and validation of the assay.

A validated high-performance liquid chromatographic method is presented to quantitate amphotericin B (AB) in a liposomal pharmaceutical formulation. The analysis is based on the chromatographic separation of AB and 1-amino-4-nitronaphthalene (the internal standard) on a C18 muBondapac reversed-phase column with a mobile phase consisting of a mixture of acetonitrile and 0.02 M ethylenediamine tetra-acetic acid disodium salt at pH 5.0 (45:55, v/v). The chromatographic analysis time is less than 10 min, and the validation of the assay shows that it is selective, accurate, and linear for the concentration range of 2.50 to 7.50 microg/mL with a detection limit of 0.00500 microg/mL. The within-day and between-day relative standard deviation values are 1.26% (n = 18) and 1.25% (n = 8), respectively. The method described conforms to the validation of compendial methods used for finished pharmaceutical products in general and offers a reliable, quick, and cost-effective procedure for examining the consistency or quality-control analysis of AB in liposomal products. It can also be applied for the determination of AB in other nonliposomal lipid-based drug delivery systems that are on the market.  (+info)

(7/350) Simultaneous determination of sweeteners and preservatives in preserved fruits by micellar electrokinetic capillary chromatography.

A micellar electrokinetic capillary method for the simultaneous determination of the sweeteners dulcin, aspartame, saccharin, and acesulfame-K and the preservatives sorbic acid; benzoic acid; sodium dehydroacetate; and methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutyl-p-hydroxybenzoate in preserved fruits is developed. These additives are ion-paired and extracted using sonication followed by solid-phase extraction from the sample. Separation is achieved using a 57-cm fused-silica capillary with a buffer comprised of 0.05 M sodium deoxycholate, 0.02 M borate-phosphate buffer (pH 8.6), and 5% acetonitrile, and the wavelength for detection is 214 nm. The average recovery rate for all sweeteners and preservatives is approximately 90% with good reproducibility, and the detection limits range from 10 to 25 microg/g. Fifty preserved fruit samples are analyzed for the content of sweeteners and preservatives. The sweeteners found in 28 samples was aspartame (0.17-11.59 g/kg) or saccharin (0.09-5.64 g/kg). Benzoic acid (0.02-1.72 g/kg) and sorbic acid (0.27-1.15 g/kg) were found as preservatives in 29 samples.  (+info)

(8/350) Lactobacillus arizonensis sp. nov., isolated from jojoba meal.

Five strains of simmondsin-degrading, lactic-acid-producing bacteria were isolated from fermented jojoba meal. These isolates were facultatively anaerobic, gram-positive, non-motile, non-spore-forming, homofermentative, rod-shaped organisms. They grew singly and in short chains, produced lactic acid but no gas from glucose, and did not exhibit catalase activity. Growth occurred at 15 and 45 degrees C. All strains fermented cellobiose, D-fructose, D-galactose, D-glucose, lactose, maltose, D-mannitol, D-mannose, melibiose, D-ribose, salicin, D-sorbitol, sucrose and trehalose. Some strains fermented L-(-)-arabinose and L-rhamnose. D-Xylose was not fermented and starch was not hydrolysed. The mean G+C content of the DNA was 48 mol%. Phylogenetic analyses of 16S rDNA established that the isolates were members of the genus Lactobacillus. DNA reassociation of 45% or less was obtained between the new isolates and the reference strains of species with G+C contents of about 48 mol%. The isolates were differentiated from other homofermentative Lactobacillus spp. on the basis of 16S rDNA sequence divergence, DNA relatedness, stereoisomerism of the lactic acid produced, growth temperature and carbohydrate fermentation. The data support the conclusion that these organisms represent strains of a new species, for which the name Lactobacillus arizonensis is proposed. The type strain of L. arizonensis is NRRL B-14768T (= DSM 13273T).  (+info)

*  Acetonitrile (data page)
Vapor Pressures of Acetonitrile Determined by Comparative Ebulliometry, Michael B. Ewing* and Jesus C. Sanchez Ochoa, Journal ... This page provides supplementary chemical data on acetonitrile. The handling of this chemical may incur notable safety ...
*  Bis(acetonitrile)palladium dichloride
... is the coordination complex with the formula PdCl2(NCCH3)2. It is the adduct of two ... Carretero, Juan Carlos; Arrayas, Ramon Gomez (2008). "Dichloro bis(acetonitrile) palladium". e-EROS Encyclopedia of Reagents ... acetonitrile ligands with palladium(II) chloride. It is a yellow-brown solid that is soluble in organic solvents. The compound ...
*  Tris(acetonitrile)cyclopentadienylruthenium hexafluorophosphate
... is an organoruthenium compound with the formula [(C5H5)Ru(NCCH3 ... The Synthesis and Reactions of a Synthetically Useful Intermediate: the Cyclopentadienyltris (acetonitrile) ruthenium (II) ... which is replaced by three equivalents of acetonitrile (MeCN): [Cp(C6H6)Ru]PF6 + 3 MeCN → [CpRu(NCMe)3]PF6 + C6H6 Gill, Thomas ...
*  Tetrakis(acetonitrile)copper(I) hexafluorophosphate
The acetonitrile ligands protect the Cu+ ion from oxidation to Cu2+. However, acetonitrile is not bound very strongly to the ... J. R. Black, W. Levason and M. Webster "Tetrakis(acetonitrile-N)copper(I) Hexafluorophosphate(V) Acetonitrile Solvate"Acta ... As the coordinated acetonitrile ligands may be displaced in other solvents, the [Cu(CH3CN)4]PF6 compound may serve as a ... Tetrakis(acetonitrile)copper(I) hexafluorophosphate is a coordination compound with the formula [Cu(CH3CN)4]PF6. It is a ...
*  Methacrylonitrile
Acetonitrile, hydrogen cyanide and acrolein are known by-products. It is used in the preparation of homo- and copolymers, ... acetonitrile. There are two types of polymers that can be obtained at the end of the synthesis; a physisorbed polymer and a ...
*  Nile red
From left to right: 1. water, 2. methanol, 3. ethanol, 4. acetonitrile, 5. dimethylformamide, 6. acetone, 7. ethyl acetate, 8. ...
*  Texas Red
The dye dissolves very well in water as well as other polar solvents, e.g., Dimethylformamide, acetonitrile. Texas Red, ...
*  Polyhedral symbol
For example, of the ligands acetonitrile, chloride ion and pyridine thepriority number assigned are chloride, 1; acetonitrile,2 ... If there are two possibilities the principle of trans difference is applied). As an example, (acetonitrile)dichlorido(pyridine) ... The ligand priority numbers are, applying the CIP rules: two chlorides of priority number 1 acetonitrile priority 2 pyridine ... acetonitrile)dichlorido(pyridine)platinum(II). The configuration index has two digits. The first digit is the priority number ...
*  Tetraethylammonium
I. Metal ions which have comparable polarographic properties in acetonitrile and in water." J. Am. Chem. Soc. 79 870-874. R. L ... I. M. Kolthoff and J. F. Coetzee (1957). "Polarography in acetonitrile. ...
*  Drug metabolism
"Acetonitrile (EHC 154, 1993)". www.inchem.org. Retrieved 2017-05-03. Akagah B, Lormier AT, Fournet A, Figadère B (December 2008 ... For example, phase I metabolism converts acetonitrile to HOCH2CN, which rapidly dissociates into formaldehyde and hydrogen ...
*  Michael Bühl
Bühl, Michael; Sieffert, Nicolas; Chaumont, Alain; Wipff, Georges (2011-01-03). "Water versus Acetonitrile Coordination to ...
*  Triphenylphosphine
"Basicity of Phosphanes and Diphosphanes in Acetonitrile". European Journal of Organic Chemistry. 2012 (11): 2167-2172. doi: ...
*  Fluoroboric acid
Titration of NBu+ 4BF− 4 in acetonitrile solution indicates that HBF4, i.e., HF.BF3, has a pKa of 1.6 in that solvent. Its ... Acetonitrile solutions cleave acetals and some ethers. Many reactive cations have been obtained using fluoroboric acid, e.g. ... Heintz, R. A.; Smith, J. A.; Szalay, P. S.; Weisgerber, A.; Dunbar, K. R. (2002). "Homoleptic Transition Metal Acetonitrile ...
*  Trifluridine
... sparingly soluble in isopropyl alcohol and acetonitrile; slightly soluble in diethyl ether; and very slightly soluble in ...
*  Vanadyl nitrate
An adduct is also formed with acetonitrile. When mixed with petrol or l-hexene, or other unsaturated hydrocarbons, vanadyl ... Vanadium metal reacts with dinitrogen tetroxide with an acetonitrile catalyst at 0 °C to yield mononitratodioxovanadium(V), ...
*  Transition metal nitrile complexes
Tetrakis(acetonitrile)copper(I) hexafluorophosphate ([Cu(MeCN)4]PF6), a colorless solid that serves as a source of naked "Cu+" ... "Acetonitrile Complexes of Selected Transition Metal Cations". Inorg. Synth. 28: 63-67. doi:10.1002/9780470132593.ch14. CS1 ... Homoleptic Transition Metal Acetonitrile Cations with Tetrafluoroborate or Trifluoromethanesulfonate Anions". Inorg. Synth. 33 ... Typical nitrile ligands are acetonitrile, propionitrile, and benzonitrile. These ligands are also popular solvents, which is ...
*  Resonance (chemistry)
Kaupmees, K.; Kaljurand, I.; Leito, I. (2014). "Influence of Water Content on Basicities in Acetonitrile". J. Sol. Chem. 43: ... "Influence of Water Content on the Acidities in Acetonitrile. Quantifying Charge Delocalization in Anions". J. Phys. Chem. A. ...
*  Selenopyrylium
Solvents include trifluoroacetic acid, methanol, dichloromethane, chloroform and acetonitrile. Many derivatives of ...
*  Steven Ittel
Coupling of Carbon Dioxide and Acetonitrile," J. Am. Chem. Soc., 100, 7577 (1978). C. A. Tolman, S. D. Ittel, A. D. English, ...
*  Aminoacetonitrile
"Detection of amino acetonitrile in Sgr B2(N)" (pdf). Astronomy and Astrophysics. 482 (1): 179-196. arXiv:0801.3219 . Bibcode: ...
*  Bis(benzonitrile)palladium dichloride
... acetonitrile)palladium dichloride. The complex is prepared by dissolving PdCl2 in warm benzonitrile. The PhCN ligands are ...
*  Ammoxidation
The solvent acetonitrile is a byproduct of this process. Ammoxidation of alkenes exploits the weak C-H bonds that are located ...
*  Nickel compounds
Nickel tetrafluoroborate, Ni(BF4)2•6H2O is very soluble in water, alcohol and acetonitrile. It is prepared by dissolving nickel ...
*  Mitsunobu reaction
The byproducts are acetonitrile (6) and the trialkylphosphine oxide (8). The Mitsunobu reaction has been applied in the ...
*  Oxatriquinacene
It reacts with water, but can be dissolved in acetonitrile. It is of interest as a possible precursor to oxaacepentalene, a ...
acetonitrile (CHEBI:38472)  acetonitrile (CHEBI:38472)
... acetonitrile (CHEBI:38472). acetonitrile oxide (CHEBI:47841) has functional parent acetonitrile (CHEBI:38472). acetonitrile ... 2-methylphenyl)acetonitrile (CHEBI:27982) has functional parent acetonitrile (CHEBI:38472). (hydroxyimino)(phenyl)acetonitrile ... acetonitrile (CHEBI:38472) has role EC 3.5.1.4 (amidase) inhibitor (CHEBI:77941) acetonitrile (CHEBI:38472) has role polar ... acetonitrile (CHEBI:38472) is a aliphatic nitrile (CHEBI:80291) acetonitrile (CHEBI:38472) is a volatile organic compound ( ...
more infohttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=38472
Acetonitrile  Acetonitrile
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C2H3N/c1-2-3/h1H3
Acetonitrile  Acetonitrile
Franklin, J.L.; Wada, Y.; Natalis, P.; Hierl, P.M., Ion-molecule reactions in acetonitrile and propionitrile, J. Phys. Chem., ... Williams, T.I.; Denault, J.W.; Cooks, R.G., Proton Affinity of Deuterated Acetonitrile Estimated by the Kinetic Method with ... Hydrogen cyanide and acetonitrile, J. Chem. Phys., 1968, 48, 4765. [all data] ... High-resolution HeI photoelectron spectrum of acetonitrile, Chem. Phys. Lett., 1992, 193, 41. [all data] ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=C75058&Units=CAL&Mask=20
Acetonitriles - definition of Acetonitriles by The Free Dictionary  Acetonitriles - definition of Acetonitriles by The Free Dictionary
Acetonitriles synonyms, Acetonitriles pronunciation, Acetonitriles translation, English dictionary definition of Acetonitriles ... acetonitrile. (redirected from Acetonitriles). Also found in: Medical, Encyclopedia. acetonitrile. (əˌsiːtəʊˈnaɪtrɪl) n. a ... Acetonitriles - definition of Acetonitriles by The Free Dictionary https://www.thefreedictionary.com/Acetonitriles ...
more infohttps://www.thefreedictionary.com/Acetonitriles
Acetonitrile | chemical compound | Britannica.com  Acetonitrile | chemical compound | Britannica.com
CH3CN is acetonitrile (from acetic acid), whereas C6H5CN is benzonitrile (from benzoic acid). ... Other articles where Acetonitrile is discussed: carboxylic acid: Nomenclature: Thus, ... Thus, CH3CN is acetonitrile (from acetic acid), whereas C6H5CN is benzonitrile (from benzoic acid). ...
more infohttps://www.britannica.com/science/acetonitrile
indole-3-acetonitrile (CHEBI:17566)  indole-3-acetonitrile (CHEBI:17566)
... has functional parent acetonitrile (CHEBI:38472) indole-3-acetonitrile (CHEBI:17566) has ... indole-3-acetonitrile (CHEBI:17566) is a indoles (CHEBI:24828) indole-3-acetonitrile (CHEBI:17566) is a nitrile (CHEBI:18379) ... indole-3-acetonitrile (CHEBI:17566) has role plant hormone (CHEBI:37848) indole-3-acetonitrile (CHEBI:17566) has role plant ... CHEBI:17566 - indole-3-acetonitrile. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ...
more infohttp://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17566
CDC - NIOSH Pocket Guide to Chemical Hazards -
Acetonitrile  CDC - NIOSH Pocket Guide to Chemical Hazards - Acetonitrile
APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus. Escape: ...
more infohttps://www.cdc.gov/niosh/npg/npgd0006.html
Acetonitrile - definition of acetonitrile by The Free Dictionary  Acetonitrile - definition of acetonitrile by The Free Dictionary
acetonitrile synonyms, acetonitrile pronunciation, acetonitrile translation, English dictionary definition of acetonitrile. n a ... acetonitrile. Also found in: Medical, Acronyms, Encyclopedia, Wikipedia. acetonitrile. (əˌsiːtəʊˈnaɪtrɪl) n. a colourless ... Acetonitrile - definition of acetonitrile by The Free Dictionary https://www.thefreedictionary.com/acetonitrile ... 30ml of acetonitrile and 10g of sodium sulfate was added in 25g of samples and homogenized in blender for 10 min.. Residue ...
more infohttps://www.thefreedictionary.com/acetonitrile
Acetonitrile HPLC grade, ≥99.93% | Sigma-Aldrich  Acetonitrile HPLC grade, ≥99.93% | Sigma-Aldrich
Acetonitrile for your research needs. Find product specific information including CAS, MSDS, protocols and references. ...
more infohttps://www.sigmaaldrich.com/catalog/product/aldrich/270717?lang=en®ion=US
2-bromophenyl)acetonitrile - Registration Dossier - ECHA  2-bromophenyl)acetonitrile - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
more infohttps://echa.europa.eu/hr/registration-dossier/-/registered-dossier/20089/2/2
Acetonitrile, HPLC Grade, ≥ 99.8%, LabChem™  Acetonitrile, HPLC Grade, ≥ 99.8%, LabChem™
path_0 : /content/fishersci/na/en_CA/special-offers-and-programs/new-lab-start-up-program/2018/100-spend100-get-100labchem-products-np-additional-cost/jcr:content/special-offers. ...
more infohttps://www.fishersci.ca/shop/products/acetonitrile-hplc-grade-99-8-labchem-1/LC104604
Diffusion coefficient of ferrocene in acetonitrile at infinite dilution | SpringerLink  Diffusion coefficient of ferrocene in acetonitrile at infinite dilution | SpringerLink
This chapter provides the diffusion coefficient of ferrocene in acetonitrile at infinite dilution for various temperature and ... Winkelmann J. (2018) Diffusion coefficient of ferrocene in acetonitrile at infinite dilution. In: Lechner M.D. (eds) Diffusion ... This chapter provides the diffusion coefficient of ferrocene in acetonitrile at infinite dilution for various temperature and ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-662-54089-3_2205
Acetonitrile supplier | CasNO.75-05-8  Acetonitrile supplier | CasNO.75-05-8
Find quality suppliers and manufacturers of Acetonitrilefor price inquiry.where to buy Acetonitrile.Also offer free database of ... Acetonitrile including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, ... Uses of Acetonitrile: Acetonitrile is used mainly as a solvent in the purification of butadiene in refineries. It is widely ... The Acetonitrile, with the register number 75-05-8, is a kind of colorless transparent liquid. Acetonitrile is the chemical ...
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3-Methoxyphenyl)acetonitrile, 97%, ACROS Organics™  3-Methoxyphenyl)acetonitrile, 97%, ACROS Organics™
3-methoxyphenyl acetonitrile, 2-3-methoxyphenyl acetonitrile, 3-methoxyphenylacetonitrile, 3-methoxybenzyl cyanide, m- ... 3-methoxyphenyl acetonitrile, 2-3-methoxyphenyl acetonitrile, 3-methoxyphenylacetonitrile, 3-methoxybenzyl cyanide, m- ... methoxyphenyl acetonitrile, 3-cyanomethyl anisole, benzeneacetonitrile, 3-methoxy, 3-methoxybenzeneacetonitrile, m- ... methoxyphenyl acetonitrile, 3-cyanomethyl anisole, benzeneacetonitrile, 3-methoxy, 3-methoxybenzeneacetonitrile, m- ...
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Diffusion coefficient of acetonitrile in dichloro-deuterio-methane at infinite dilution | SpringerLink  Diffusion coefficient of acetonitrile in dichloro-deuterio-methane at infinite dilution | SpringerLink
This chapter provides the diffusion coefficient of acetonitrile in dichloro-deuterio-methane at infinite dilution for various ... This chapter provides the diffusion coefficient of acetonitrile in dichloro-deuterio-methane at infinite dilution for various ... Winkelmann J. (2018) Diffusion coefficient of acetonitrile in dichloro-deuterio-methane at infinite dilution. In: Lechner M.D ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-662-54089-3_1424
Patent US6780289 - Process for the purification and recovery of acetonitrile - Google Patents  Patent US6780289 - Process for the purification and recovery of acetonitrile - Google Patents
... withdrawing a first side draw fraction comprising acetonitrile, distilling the first side draw fraction in a second fractional ... and withdrawing from the second distillation a second side draw fraction comprising purified acetonitrile. ... A method for the purification of crude acetonitrile comprising distilling the crude acetonitrile in a first fractional ... Acetonitrile feed, either crude acetonitrile, recycle acetonitrile or a combination thereof is fed via inlet line 9 and water ...
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CDC - Immediately Dangerous to Life or Health Concentrations (IDLH):  Acetonitrile -  NIOSH Publications and Products  CDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Acetonitrile - NIOSH Publications and Products
Basis for revised IDLH: The revised IDLH for acetonitrile is 500 ppm based on acute inhalation toxicity data in humans [ ... Pozzani UC, Carpenter CP, Palm PE, Weil CS, Nair JH III [1959]. An investigation of the mammalian toxicity of acetonitrile. J ... AIHA [1960]. Acetonitrile. In: Hygienic guide series. Am Ind Hyg Assoc J 21:265-266. ... Deichmann WB, Gerarde HW [1969]. Acetonitrile (methyl cyanide; ethanenitrile). In: Toxicology of drugs and chemicals. New York ...
more infohttps://www.cdc.gov/niosh/idlh/75058.html
Diphenyl Acetonitrile Manufacturers, Suppliers & Exporters in India  Diphenyl Acetonitrile Manufacturers, Suppliers & Exporters in India
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Deepoxy-deoxynivalenol 50 µg/mL in Acetonitrile  Deepoxy-deoxynivalenol 50 µg/mL in Acetonitrile
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  • The aim of this work was to explore the behaviour of proteins on different Zorbax stationary phases with acetonitrile and methanol as organic modifiers during reversed-phase high-performance liquid chromatography. (thefreedictionary.com)
  • This chapter provides the diffusion coefficient of ferrocene in acetonitrile at infinite dilution for various temperature and pressure conditions measured using Taylor dispersion technique. (springer.com)
  • This chapter provides the diffusion coefficient of acetonitrile in dichloro-deuterio-methane at infinite dilution for various temperature and pressure conditions measured using NMR spin echo pulse gradient. (springer.com)
  • In a typical reaction, 4-chloro-3-nitro-2H-benzopyran-2-one 2, equimolar amounts of 3aminotriazole 3(a-b), respectively 2aminobenzothiazole 3(c-e) and a catalytic amount of triethylamine in acetonitrile were refluxed in a water bath for 1-16 h. (thefreedictionary.com)
  • 2. The method of claim 1 wherein the crude acetonitrile comprises crude acetonitrile produced by the catalytic ammoxidation of propylene or propane. (google.com)
  • A method for the purification of crude acetonitrile comprising distilling the crude acetonitrile in a first fractional distillation column at below atmospheric pressure, withdrawing a first side draw fraction comprising acetonitrile, distilling the first side draw fraction in a second fractional distillation. (google.com)
  • More particularly, this invention is an improved process for the purification of crude acetonitrile produced, for example, as a byproduct during the formation of acrylonitrile by the ammoxidation of an olefin such as propylene or the ammoxidation of propane. (google.com)
  • Acetonitrile is also used as a raw material for the preparation of other chemicals used in the chemical and pharmaceutical industry. (google.com)
  • Starting in October 2008, the worldwide supply of Acetonitrile was low because Chinese production was shut down for the Olympics. (lookchem.com)
  • This invention is an improved process for the production of acetonitrile. (google.com)
  • 4. The method of claim 1 wherein the crude acetonitrile comprises about 38 to 78 weight percent acetonitrile, about 20 to about 68 weight percent water, and about 0.01 to about 10 weight percent HCN. (google.com)
  • 7. The method of claim 1 wherein the crude acetonitrile comprises water and wherein the first side draw fraction comprises about 82 to about 90 weight percent acetonitrile and about 8 to about 16 weight percent water. (google.com)
  • 13. The method of claim 11 wherein the amount of water added is such that the weight ratio of water added to acetonitrile present in the crude acetonitrile is about 0.1:1 to about 10:1. (google.com)
  • 8. The method of claim 1 wherein the crude acetonitrile comprises HCN and wherein the first side draw fraction further comprises HCN and is treated to reduce the amount of HCN contained therein prior to distilling the first side draw fraction in the second distillation column. (google.com)
  • 9. The method of claim 1 wherein the crude acetonitrile comprises HCN and is treated to remove HCN prior to distillation in the first fractional distillation column. (google.com)