Compounds in which a methyl group is attached to the cyano moiety.

Efficient nitroso group transfer from N-nitrosoindoles to nucleotides and 2'-deoxyguanosine at physiological pH. A new pathway for N-nitrosocompounds to exert genotoxicity. (1/350)

The endogenous formation of N-nitrosoindoles is of concern since humans are exposed to a variety of naturally occurring and synthetic indolic compounds. As part of a study to evaluate the genotoxicity of N-nitrosoindoles, the reactions of three model compounds with purine nucleotides and 2'-deoxyguanosine at physiological pH were investigated. The profiles of reaction products were identical for each of the N-nitrosoindoles and three distinct pathways of reaction could be discerned. These pathways were: (i) depurination to the corresponding purine bases, (ii) deamination, coupled with depurination, to give hypoxanthine and xanthine, and (iii) formation of the novel nucleotide 2'-deoxyoxanosine monophosphate and its corresponding depurination product oxanine in reactions with 2'-deoxyguanosine monophosphate. 2'-Deoxyoxanosine and oxanine were observed in reactions with 2'-deoxyguanosine. Further studies showed that formation of all of these products could be rationalized by an initial transnitrosation step. These results suggest that, in contrast to many other genotoxic N-nitrosocompounds which are known to alkylate DNA, the genotoxicity of N-nitrosoindoles is likely to arise through transfer of the nitroso group to nucleophilic sites on the purine bases. All of the products resulting from transnitrosation by N-nitrosoindoles are potentially mutagenic. These findings reveal a new pathway for N-nitrosocompounds to exert genotoxicity.  (+info)

Studies of structure and mechanism in acetonitrile chemical ionization tandem mass spectrometry of polyunsaturated fatty acid methyl esters. (2/350)

Recently it has been shown that acetonitrile chemical ionization tandem mass spectrometry (CI-MS/MS) is a rapid, on-line means to determine double bond position in fatty acid methyl esters (FAME). The mechanism of this gas phase condensation reaction has been studied. Evidence of the (1-methyleneimino)-1-ethenylium ion (m/z 54), formed upon the reaction of acetonitrile with itself, adding across the double bond in a [2 + 2] cycloaddition reaction is observed. When this nascent complex undergoes collision-induced dissociation, two diagnostic ions emerge. One of these ions results from loss of the hydrocarbon end of the FAME, whereas the other ion results from loss of the methyl ester end, and when considered together, the diagnostic ions localize the positions of the double bonds in the FAME. Several labeling and MS/MS/MS experiments on the two diagnostic ions were performed to determine a plausible fragmentation mechanism of the stable (1-methyleneimino)-1-ethenylium-FAME complex. The first generation product ions, or diagnostic ions, appear to be formed though a charge-driven mechanism, whereas the second generation product ions are formed via charge-remote fragmentations. Plausible mechanisms for the formation and subsequent dissociation of the diagnostic ions are presented for the monounsaturated, diunsaturated, and polyunsaturated (3 or more double bonds) FAME.  (+info)

Stimulation of tolbutamide hydroxylation by acetone and acetonitrile in human liver microsomes and in a cytochrome P-450 2C9-reconstituted system. (3/350)

Organic solvents are often used to solubilize lipophilic new chemical entities before their addition to in vitro test systems such as microsomal stability or cytochrome P-450 (CYP) inhibition. However, the effect of these organic solvents on the test systems is not usually characterized. This study was initiated to evaluate the effect of acetonitrile and acetone, in addition to other organic solvents, on the tolbutamide hydroxylation activity of CYP2C9 in both human liver microsomes and a CYP2C9-reconstituted system. Both acetonitrile and acetone significantly stimulated the NADPH-dependent tolbutamide hydroxylation by nearly 2- to 3-fold in human liver microsomes and CYP2C9-reconstituted system when incubated at 2 and 4% final solvent concentrations. When cumene hydroperoxide was used instead of NADPH, both acetone and acetonitrile significantly inhibited tolbutamide hydroxylation. This NADPH-dependent stimulatory effect was further evaluated by examining the effect of a series of other organic solvents with different carbon chain lengths and various functional groups, including hydroxyl, ketone, and aldehyde. Unlike acetone, two other ketone-containing solvents, methyl ethyl ketone (2-butanone) and diethyl ketone (3-pentanone) failed to significantly enhance tolbutamide hydroxylation. Other solvents tested, including methanol, ethanol, propanol, 1-butanol, 2-butanol, 1-pentanol, 2-pentanol, acetaldehyde, and dimethyl sulfoxide significantly inhibited NADPH-dependent tolbutamide hydroxylation. Overall, the stimulatory effect of both acetonitrile and acetone on tolbutamide hydroxylation was found to be primarily due to a consistent increase in V(max), whereas K(m) was unchanged in both human liver microsomes and the reconstituted CYP2C9 system. These data suggest that acetone and acetonitrile stimulate NADPH-mediated tolbutamide hydroxylation via the CYP reductase and not by modifying the affinity of tolbutamide for the CYP2C9 enzyme.  (+info)

Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity. (4/350)

Acetonitrile is an organic solvent commonly used to increase the solubility of lipophilic substrates for in vitro studies. In this study, we examined its effect on four reactions (diclofenac hydroxylation, tolbutamide methyl hydroxylation, phenytoin hydroxylation, and celecoxib methyl hydroxylation) catalyzed by human liver microsomes and by the recombinant CYP2C9. In both cases, the effect of acetonitrile on activity was found to be substrate-dependent. Namely, it increased diclofenac 4'-hydroxylase and tolbutamide methyl hydroxylase activities, but decreased celecoxib methyl hydroxylase activity in a concentration-dependent manner. By comparison, hydroxylation of phenytoin was resistant to its effect. The presence of acetonitrile (3%, v/v) gave rise to a lower K(m) and a higher V(max) for diclofenac hydroxylase in both liver microsomes and recombinant CYP2C9 preparations (87 and 52% increase in V(max)/K(m) ratio, respectively). On the other hand, the inhibitory effect of the solvent (1%, v/v) toward celecoxib hydroxylase was characterized by a decrease in V(max) (human liver microsomes) or a change in both K(m) and V(max) (rCYP2C9), leading to 25 and 46% decrease in V(max)/K(m) for both systems. The results of this study underscore the need for careful evaluation of solvent effects before initiation of inhibition or cytochrome P450 reaction phenotyping studies.  (+info)

High-throughput method development approaches for bioanalytical mass spectrometry. (5/350)

A rational approach to the development and optimization of solid-phase extraction (SPE) methods is described. The semiautomated scheme allows for the simultaneous testing of multiple chemistries using a custom multiple-sorbent 96-well method development plate. Optimized extraction conditions for up to five analytes are determined in a single 2.5-h experiment. The experiment can be tailored to determine SPE conditions (including wash protocols) for related analytes. Data obtained by liquid chromatography-atmospheric pressure ionization-mass spectrometry allows the quantitation of absolute recovery and selection of the best extraction conditions for approximately 100 analytes of diverse structure. Optimized extraction protocols yielding at least 80% recovery are determined for 81% of the analytes. For 96% of the analytes screened, extraction conditions resulting in recoveries of > or = 60% are determined. The most generic set of SPE conditions consist of either C8 or C18 sorbent with an eluent composition of acetonitrile with 5mM nitric acid added.  (+info)

High-performance liquid chromatographic determination of amphotericin B in a liposomal pharmaceutical product and validation of the assay. (6/350)

A validated high-performance liquid chromatographic method is presented to quantitate amphotericin B (AB) in a liposomal pharmaceutical formulation. The analysis is based on the chromatographic separation of AB and 1-amino-4-nitronaphthalene (the internal standard) on a C18 muBondapac reversed-phase column with a mobile phase consisting of a mixture of acetonitrile and 0.02 M ethylenediamine tetra-acetic acid disodium salt at pH 5.0 (45:55, v/v). The chromatographic analysis time is less than 10 min, and the validation of the assay shows that it is selective, accurate, and linear for the concentration range of 2.50 to 7.50 microg/mL with a detection limit of 0.00500 microg/mL. The within-day and between-day relative standard deviation values are 1.26% (n = 18) and 1.25% (n = 8), respectively. The method described conforms to the validation of compendial methods used for finished pharmaceutical products in general and offers a reliable, quick, and cost-effective procedure for examining the consistency or quality-control analysis of AB in liposomal products. It can also be applied for the determination of AB in other nonliposomal lipid-based drug delivery systems that are on the market.  (+info)

Simultaneous determination of sweeteners and preservatives in preserved fruits by micellar electrokinetic capillary chromatography. (7/350)

A micellar electrokinetic capillary method for the simultaneous determination of the sweeteners dulcin, aspartame, saccharin, and acesulfame-K and the preservatives sorbic acid; benzoic acid; sodium dehydroacetate; and methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutyl-p-hydroxybenzoate in preserved fruits is developed. These additives are ion-paired and extracted using sonication followed by solid-phase extraction from the sample. Separation is achieved using a 57-cm fused-silica capillary with a buffer comprised of 0.05 M sodium deoxycholate, 0.02 M borate-phosphate buffer (pH 8.6), and 5% acetonitrile, and the wavelength for detection is 214 nm. The average recovery rate for all sweeteners and preservatives is approximately 90% with good reproducibility, and the detection limits range from 10 to 25 microg/g. Fifty preserved fruit samples are analyzed for the content of sweeteners and preservatives. The sweeteners found in 28 samples was aspartame (0.17-11.59 g/kg) or saccharin (0.09-5.64 g/kg). Benzoic acid (0.02-1.72 g/kg) and sorbic acid (0.27-1.15 g/kg) were found as preservatives in 29 samples.  (+info)

Lactobacillus arizonensis sp. nov., isolated from jojoba meal. (8/350)

Five strains of simmondsin-degrading, lactic-acid-producing bacteria were isolated from fermented jojoba meal. These isolates were facultatively anaerobic, gram-positive, non-motile, non-spore-forming, homofermentative, rod-shaped organisms. They grew singly and in short chains, produced lactic acid but no gas from glucose, and did not exhibit catalase activity. Growth occurred at 15 and 45 degrees C. All strains fermented cellobiose, D-fructose, D-galactose, D-glucose, lactose, maltose, D-mannitol, D-mannose, melibiose, D-ribose, salicin, D-sorbitol, sucrose and trehalose. Some strains fermented L-(-)-arabinose and L-rhamnose. D-Xylose was not fermented and starch was not hydrolysed. The mean G+C content of the DNA was 48 mol%. Phylogenetic analyses of 16S rDNA established that the isolates were members of the genus Lactobacillus. DNA reassociation of 45% or less was obtained between the new isolates and the reference strains of species with G+C contents of about 48 mol%. The isolates were differentiated from other homofermentative Lactobacillus spp. on the basis of 16S rDNA sequence divergence, DNA relatedness, stereoisomerism of the lactic acid produced, growth temperature and carbohydrate fermentation. The data support the conclusion that these organisms represent strains of a new species, for which the name Lactobacillus arizonensis is proposed. The type strain of L. arizonensis is NRRL B-14768T (= DSM 13273T).  (+info)

Sigma-Aldrich offers a number of Acetonitrile solution products. View information & documentation regarding Acetonitrile solution, including CAS, MSDS & more.
TY - JOUR. T1 - Microscopic trends in methanol/water and acetonitrile/water systems. AU - Alzweiri, Muhammed. AU - Parkinson, John. AU - Watson, David. AU - Steer, Steven. PY - 2011. Y1 - 2011. N2 - Examination of some trends and differences between acetonitrile/water and methanol/water mixtures has been carried out. These systems are of interest for chromatographers since they are common mobile constituents. Some differences in the molecular arrangement of these solvents were observed from NMR and IR results. These observations might be of use in understanding and developing chromatographic separations. IR studies revealed C-H bond compression in methanol compared with acetonitrile which indicates different molecular arrangement in their aqueous mixtures. NMR and IR results show a clear non-linear behaviour in molecular arrangement. This justifies the deviation of methanol and acetonitrile aqueous solution from the norm. However, both solvents showed similar ionization suppression effects on ...
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A system includes a process-related-data handling component operative to handle process-related data corresponding to an operation associated with an artifact, such as the creation or revision of the artifact. An application component is operatively coupled to the process-related-data handling module and is operative to interact with the artifact. A storage element is also operatively coupled to the process-related-data handling module and is operative to store the process-related data. The process-related data may be displayed, created, or otherwise manipulated through a data management tool, which may include, a calendar interface, a task interface, and/or a media capture module. A method is also directed towards establishing process-related context concerning at least one artifact.
Acetonitrile (also called methyl cyanide, ethanenitrile, ethyl nitrile, etc.) is the simplest organic nitrile with the molecular formula of C2H3N. It is a clear, flammable liquid, melting and boiling at -45°C and 82°C respectively. Acetonitrile is miscible with water and with common organic solvents, but immiscible with many saturated hydrocarbons (alkanes).. Acetonitrile is produced by dehydration of acetamide or by the reaction of ethanol and ammonia in the presence of catalyst such as Ag, Cu, MoO3, and ZnS at moderate temperatures as well as a by-product from the manufacture of acrylonitrile. Acetonitrile can also obtained by the reaction of cyanogen chloride with methane, ketones, ethanol, alkylene epoxides, and paraffins.. Acetonitrile finds its greatest use as an extractive distillation solvent in the petrochemical industry for separating olefin-diolefin mixtures and for C4-hydrocarbons.. It is widely used in battery applications because of its relatively high dielectric constant and ...
The charge transfer (CT) interaction of 2-aminopyrimidine (AP) with chloranilic acid (CLA) as π-acceptor was investigated spectrophotometrically in acetonitrile at different temperatures in the range of 25-50 C. The 1:1 stoichiometry of the synthesized CT complex was detected using straight line method. Benesi-Hildebrand equation was used to determine the association constant (K ), molar extinction coefficient (ε) and other physical parameters. Various thermodynamics parameters such as enthalpy (ΔH), entropy (ΔS) and free energy (ΔG) were determined using UV-Visible spectrophotometry in acetonitrile at different temperatures. H NMR, FTIR, ESI-MS, elemental analyses, and UV-Visible techniques were used to characterize the hydrogen-bonded CT complex. H NMR spectroscopy was also used for the analysis of the CT complex where both hydrogen bond and charge transfer were present in its molecular composition. The interaction of the selected organic compound with Ct-DNA was well investigated using ...
Early buyers will receive 10% customization on reports.. The derivative type segment of the acetonitrile market is projected to grow at the highest CAGR during the forecast period, in terms of value.. In terms of value, the derivative type segment of the acetonitrile market is projected to grow at the highest CAGR during the forecast period due to the increased use of acetonitrile in pharmaceutical and analytical industry applications. As a derivative, acetonitrile is widely used in the pharmaceutical industry for manufacturing Vitamin B1 and sulfa pyrimidine. It is also used as a raw material for manufacturing agriculture pesticides and aromatizers. Moreover, the increased consumption of acetonitrile in the production of epoxy hardeners and agrochemicals is also driving the growth of derivative type segment of the acetonitrile market.. The pharmaceutical application segment is projected to lead the acetonitrile market between 2017 and 2022, in terms of value.. In terms of value, the ...
TY - JOUR. T1 - NITROAZINES - CH-ACTIVE ACETONITRILES AS 1,3-BIFUNCTIONAL REAGENTS IN 6-NITROAZOLO-[1,5-A]PYRIMIDINES TRANSFORMATIONS TO 2-AZOLYLAMINO-5-NITROPYRIDINES. AU - Rusinov, V. L.. AU - Andrey A. Tumashov, Andrey A.. AU - Sidorov, E. O.. AU - Karpin, I. V.. AU - Chupakhin, O. N.. PY - 1993/4. Y1 - 1993/4. KW - RING TRANSFORMATIONS. KW - 6-NITROAZOLO,1,5-A,PYRIMIDINES. KW - DERIVATIVES. UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=A1993MK50700019. M3 - Статья. VL - 29. SP - 789. EP - 793. JO - Журнал органической химии. JF - Журнал органической химии. SN - 0514-7492. IS - 4. ER - ...
The synthesis and physicochemical properties of 2-(5-methoxyphenyl-1H-1,2,4-triazole-3-ylthio) acetonitriles and their iminoethers
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Absorption Quantitative data are not available for absorption of acetonitrile from the gastrointestinal or respiratory tract, although sufficient absorption can occur to induce systemic toxicity as evidenced by animal and human toxicity data. The dermal absorption of acetonitrile has been studied quantitatively. In a guideline (OECD 428 equivalent) and GLP study conducted by Haskell Laboratories (2005), the in vitro absorption of acetonitrile through human cadaver skin was shown to be low. The permeability coefficient was calculated to be 1.82 x 10-4cm/h. Short-term penetration rates were calculated to be 375.6 μg equiv/cm2/h (10 minute exposure) and 66.0 μg equiv/cm2/h (60 minute exposure). The majority of an infinite dose of acetonitrile was removed from the skin surface at the end of the 8-hour exposure, and only a small portion penetrated the skin and was recovered in the receptor fluid (0.24%). Following a 10- and 60-minute exposure, a major portion of a finite dose was recovered in the ...
Two new dinuclear nickel(II) complexes namely [Ni2(L1)2(OAc)2(H2O)2].CH3CN (1) and [Ni2(L2)2(SCN)2(CH3OH)2].CH3OH (2) have been synthesized from designed Schiff-base ligand 4-Bromo-2-[(2-hydroxy-1,1-dimethyl-ethylimino)-methyl]-phenol (HL1) and its reduced analogue 4-Bromo-2-[(2-hydroxy-1,1-dimethyl-ethylamino)-methyl]-phenol (HL2), respectively. Both 1 and 2 have been characterised by usual physicochemical techniques (UV-Vis, FT-IR, ESI-MS study, Single crystal XRD) and their variable temperature magnetic study has been performed. The nickel(II) centres in the dinuclear complexes 1 and 2 are antiferromagnetically coupled through participation of bridging phenoxyl oxygen. In acetonitrile solution both 1 and 2 retain their dinuclear structural integrity as is evident from ESI-MS study. Catecholase like activity of 1 and 2 have been performed in acetonitrile medium using 3, 5 -di-tert-butylcatechol (3, 5-DTBC) as model substrate. Complex 1 shows higher catalytic activity than that of... Read more ...
Two new dinuclear nickel(II) complexes namely [Ni2(L1)2(OAc)2(H2O)2].CH3CN (1) and [Ni2(L2)2(SCN)2(CH3OH)2].CH3OH (2) have been synthesized from designed Schiff-base ligand 4-Bromo-2-[(2-hydroxy-1,1-dimethyl-ethylimino)-methyl]-phenol (HL1) and its reduced analogue 4-Bromo-2-[(2-hydroxy-1,1-dimethyl-ethylamino)-methyl]-phenol (HL2), respectively. Both 1 and 2 have been characterised by usual physicochemical techniques (UV-Vis, FT-IR, ESI-MS study, Single crystal XRD) and their variable temperature magnetic study has been performed. The nickel(II) centres in the dinuclear complexes 1 and 2 are antiferromagnetically coupled through participation of bridging phenoxyl oxygen. In acetonitrile solution both 1 and 2 retain their dinuclear structural integrity as is evident from ESI-MS study. Catecholase like activity of 1 and 2 have been performed in acetonitrile medium using 3, 5 -di-tert-butylcatechol (3, 5-DTBC) as model substrate. Complex 1 shows higher catalytic activity than that of... Read more ...
Darstellung, Struktur und Eigenschaften von P(C6H5)4SeOCl3, P(C6H5)4SeOBr3 und As(C6H5)4SeOBr3 Oxotrihalogenoselenates(IV): Preparation, Structure and Properties of P(C6H5)4SeOCl3, P(C6H5)4SeOBr3 and As(C6H5)4SeOBr3 The novel oxotribromosolenate(IV) SeOBr3~ anion was prepared from the reaction of stoichiometric quantities of SeOBi2 and bromide in acetonitrile solution, and it was isolated as the tetraphenylphosphonium and -arsonium salts in crystalline form. For the synthesis of the analogous SeOCl3 _ as P(C6H5)4SeOCl3, SeCl4 was reacted in the presence of a small quantity of H«() with P(CeH5)4Cl in acetonitrile. Complete N-ray structural analyses of P(C6H5)4SeOCi3 (space group P I, a = 10.981(3), b = 11.059(3), c = 10.358(3) A, a = 73.77(2)°, ß = 83.33(2)°, -/ = 80.51(2)°, V -1187.9(6) A 3) and of P(C6H5)4SeOBr3 (space group P 2i/c, a = 11.719(4), b = 16.088(4), c = 13.124(4) A, ß = 94.72(3)°, V = 2466(1) A 3) show dimeric centrosymmetric Se202Cl6 2-and Se202Br6 2 -anions being present ...
Darstellung, Struktur und Eigenschaften von P(C6H5)4SeOCl3, P(C6H5)4SeOBr3 und As(C6H5)4SeOBr3 Oxotrihalogenoselenates(IV): Preparation, Structure and Properties of P(C6H5)4SeOCl3, P(C6H5)4SeOBr3 and As(C6H5)4SeOBr3 The novel oxotribromosolenate(IV) SeOBr3~ anion was prepared from the reaction of stoichiometric quantities of SeOBi2 and bromide in acetonitrile solution, and it was isolated as the tetraphenylphosphonium and -arsonium salts in crystalline form. For the synthesis of the analogous SeOCl3 _ as P(C6H5)4SeOCl3, SeCl4 was reacted in the presence of a small quantity of H«() with P(CeH5)4Cl in acetonitrile. Complete N-ray structural analyses of P(C6H5)4SeOCi3 (space group P I, a = 10.981(3), b = 11.059(3), c = 10.358(3) A, a = 73.77(2)°, ß = 83.33(2)°, -/ = 80.51(2)°, V -1187.9(6) A 3) and of P(C6H5)4SeOBr3 (space group P 2i/c, a = 11.719(4), b = 16.088(4), c = 13.124(4) A, ß = 94.72(3)°, V = 2466(1) A 3) show dimeric centrosymmetric Se202Cl6 2-and Se202Br6 2 -anions being present ...
Reduction of Isoquinoline N-Oxide (1) to Isoquinoline. 1) TiCl3: TiCl3 (300 μl) was added to an ice-cold solution of 14.1 mg of 1 in 1 ml of methanol. The mixture was kept on ice for 1 h and neutralized with 500 μl of 5 N KOH. 2) TiCl4/NaI: TiCl4 (500 μl) and 30 mg of NaI were added to a stirred solution of 10.7 mg of 1 in 1 ml of acetonitrile at room temperature. After 1 h, the reaction mixture was neutralized with 500 μl of 5N KOH. 3) PMHS: PMHS (36 μl) and 2.5 mg of Pd(PPh3)4 were added to a solution of 29.04 mg of 1 in 2 ml of THF at room temperature, and the mixture was stirred for 2 h. LC/MS analysis was performed on a Shimadzu VP Series (Shimadzu Scientific Instruments, Inc., Columbia, MD) consisting of a SIL-10AXL autosampler and Surveyor PDA detector. Separations were carried out on an Inertsil ODS3 column (2.1 × 150 mm, 5-μm particle size; MetaChem Technologies Inc., Torrance, CA) with a flow rate of 0.25 ml/min. The mobile phase consisted of 0.2% formic acid (mobile phase A) ...
Research in fluorescence microscopy presents new challenges, especially with respect to the development of new metal-based fluorophores. In this work, new fac-[Re(CO)3(bpy)L]PF6 (C3) and fac-[Re(CO)3(dmb)L]PF6 (C4) complexes, where L is an ancillary ligand, E-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol, both exhibiting an intramolecular hydrogen bond, have been synthesized for use as preliminary probes for fluorescence microscopy. The complexes were characterized using chemical techniques such as UV-vis, 1H-NMR, TOCSY, FT-IR, cyclic voltammetry, mass spectrometry (EI-MS 752.22 M+ for C3 and 780.26 M+ for C4) and DFT calculations including spin orbit effects. The electron withdrawing nature of the ancillary ligand L in C3 and C4 explains their electrochemical behavior, which shows the oxidation of ReI at 1.84 V for C3 and at 1.88 V for C4. The UV-vis absorption and emission properties have been studied at room temperature in acetonitrile solution. The complexes show luminescent ...
A detailed computational characterization of the one-photon absorption spectrum of a 2-((E)-2-[2,2′]-bithiophenyl-5-yl-vinyl)-1-methyl-quinolinium cation in acetonitrile solution is presented. The main physico-chemical effects (solvation, vibronic progression) affecting the band position and shape are progre
On the basis of practice-oriented questions, students are introduced to the basics of mathematical modeling by scientists in various modules. Mathematical contents, such as angle sentences or matrix calculations, are applied which the students may already know from class. In addition to content competences, process-related competences in particular are promoted in the workshops. This includes problem solving and modeling, but also communication and argumentation as well as the use of tools (e.g. e-learning units, MATLAB, GeoGebra). For this purpose, the pupils work interactively in small groups on the problem and acquire the knowledge and the solutions themselves in the action-oriented modules. ...
Rapid quantification of process-related contaminants enables data-driven decisions to be made throughout the biotherapeutics workflow.
In the first post in our series on Distributed Development challenges and solutions, we examined people-related enablers. In this second post, we will look at process-related enablers.
On Thu, 08 Mar 2012 14:54:36 +0100, Lars Erik Bolstad ,[email protected], wrote: , Sorry for the rather late response here. , We discussed this at our f2f meeting earlier this week. , , Were about to request transition to CR for the DeviceOrientation Events , spec and from a purely process-related view were concerned about , introducing a dependency to DOM4 at this point. , , In the interest of wrapping up the work were chartered to do as a , working group now and not in 9-12 months, we decided to keep the , reference to DOM2 Events. FWIW, introducing new init*Event() methods at this stage is not really acceptable, no matter what the dependency is. And not defining an event constructor as per DOM also seems questionable, but that is at least something you could fix in the future. Also, you already depend on HTML, which depends on the latest DOM, so it seems really weird to then also depend on some really crappy out of date draft. Unrelated, the IDL in ...
Sigma-Aldrich offers Aldrich-270717, Acetonitrile for your research needs. Find product specific information including CAS, MSDS, protocols and references.
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TY - JOUR. T1 - Desalting electroeluted proteins with hydrophilic interaction chromatography. AU - Jeno, P.. AU - Scherer, P. E.. AU - Manningkrieg, U.. AU - Horst, M.. PY - 1993/12. Y1 - 1993/12. N2 - We describe a chromatographic procedure for the removal of sodium dodecyl sulfate (SDS) from proteins isolated by electroelution. It involves chromatography of electroeluates on poly(2-hydroxyethyl-aspartamide) silica, a support initially developed for hydrophilic interaction chromatography. The electroeluate, dialyzed against ammonium bicarbonate-SDS buffer, is directly injected onto the column, which is equilibrated in an n-propanol concentration greater than 60%. Bound proteins are eluted with a gradient of decreasing n-propanol. This procedure removes essentially all of the Coomassie blue-related contaminants and separates SDS from the protein. Due to the use of volatile buffer systems, the proteins are recovered in completely salt-free form, which facilitates further protein manipulation. ...
Examination of some trends and differences between acetonitrile/water and methanol/water mixtures has been carried out. These systems are of interest for chromatographers since they are common mobile constituents. Some differences in the molecular arrangement of these solvents were observed from NMR and IR results. These observations might be of use in understanding and developing chromatographic separations. IR studies revealed C-H bond compression in methanol compared with acetonitrile which indicates different molecular arrangement in their aqueous mixtures. NMR and IR results show a clear non-linear behaviour in molecular arrangement. This justifies the deviation of methanol and acetonitrile aqueous solution from the norm. However, both solvents showed similar ionization suppression effects on examples of weak acids and bases.. ...
Hazardous Materials Category 4-1(Water Soluble)-II,Deleterious-P.G II,ISHL Article 57 (Labeling),CSCL Priority Assessment,UN: Class 3 - Flamm. liq.,PRTR Class 1 Designated Chemical,ISHL Article 57-2 (Deliver of Document ...
Glycosylations range among the most common posttranslational modifications with an estimated 50% of all proteins supposed to be glycosylated. These modifications are required for essential cellular processes including cell-cell recognition, protein structure and activity, e.g., of surface receptors, as well as subcellular localization of proteins. Beside the elucidation of the carbohydrate structures, the annotation of glycosylation sites is of primary interest as a basis for subsequent functional characterization. Although mass spectrometry is the method of choice for large-scale analysis of glycosylation sites, it requires initial enrichment of glycopeptides prior mass spectrometric detection in most cases. In this paper, we present a novel approach for glycopeptide enrichment by electrostatic repulsion hydrophilic interaction chromatography (ERLIC). Glycopeptides were separated from the bulk of non-modified peptides and gradually eluted from the stationary phase with potential for isoform resolution.
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Iogenic compound aeroplysinin-1 could also be a He ``counter-culture, and have entrenched associations with cannabis use and cultivation potential
The analysts forecast the global Acetonitrile (ACN, CAS 75-05-8) Market to exhibit a CAGR of 4.69% during the period 2019-2024. The report covers the present scenario and the growth prospects of the global acetonitrile for 2019-2024. To calculate the market size, the report considers the acetonitrile sales volume and revenue.. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: regional markets, product, and application.. Geographically, the global acetonitrile market is segmented into North America, Asia Pacific, Europe, Middle East & Africa and South America. This report forecasts revenue growth at a global, regional & country level, and provides an analysis of the market trends in each of the sub-segments from 2019 to 2024. ...
3-(Dimethylamino)propionitrile, 98%, ACROS Organics™ 100mL; Glass bottle 3-(Dimethylamino)propionitrile, 98%, ACROS Organics™ Dimethylaminob to Dimethylaz...
Whole blood from the subjects will be drawn 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours post clopidogrel dose. Once the blood is drawn, the metabolite will be derivatized to keep the metabolite stable in blood. Derivatization of the metabolite, involves spiking blood samples with 2-bromo-3methoxyacetophenone contained in an acetonitrile solution. Once derivatization has been done, metabolite levels will be analyzed using liquid chromatography mass spectrometry (LCMS). Once concentration levels of the active metabolite are known, the area under the curve will be calculated under trapezoid rule (linear up, log down ...
Three new compounds, (GuaH)4[W10O32](H2O)4 (1), (ThbH)3(H3O)[(W10O32](H2O)7.5 (2) and (ThbH)2[W6O19](H2O)2 (3) (GuaH = guaninium, thbH = theobrominium) were synthesized in acidified acetonitrile solutions. The polyoxotungstates in all of these compounds are surrounded by an organic matrix consisting of protonated purine bases and water molecules. The distinctive structural arrangement of the aromatic organic cations around the polyoxoanions parallel to their faces is reminiscent of nanosized boxes. The results of IR spectroscopy are consistent with previously reported results for polyoxotungstates and neat organic compounds. The polyoxoanions are reduced to tungsten(IV) oxide upon heating over 400 °C in an intramolecular redox reaction.
Precise vapor pressure data for pure acetonitrile and (LiBr + acetonitrile) are given for temps. ranging from 298.15 to 343.15 K. The molality range is from m = (0.0579 to 0.8298) mol/kg-1. The osmotic coeffs. are calcd. by taking into account the second virial coeff. of acetonitrile. The parameters of the extended Pitzer ion interaction model of Archer and the mole fraction-based thermodn. model of Clegg-Pitzer are evaluated. These models accurately reproduce the available osmotic coeffs. The parameters of the extended Pitzer ion interaction model of Archer are used to calc. the mean molal activity coeffs. ...
Acetonitrile 75-05-8 Suppliers,provide Acetonitrile 75-05-8 product and the products related with China (Mainland) Acetonitrile 75-05-8 Henan Allgreen Chemical Co.,Ltd China (Mainland)
A normal-phase Bondapak high performance liquid chromatographic (HPLC) system was compared to two different reversed-phase Bondapak C//1//8 systems for separating and quantifying aldehydes and ketones. In the normal-phase system, isocratic elution with 2-propanol (IPA) and hexane produced the best results. One reversed-phase system consisted of two C//1//8 columns in series. The other reversed-phase system consisted of a single radial compression cartridge (RCC). Both reversed-phase systems employed solvent programming with acetonitrile/water as the mobile phase. Ultraviolet (UV) detection at 340 nm was used in all of the systems.
OA Text is an independent open-access scientific publisher showcases innovative research and ideas aimed at improving health by linking research and practice to the benefit of society.
Biomanufacturers face a conflict between low-cost generic host cell protein (HCP) assays and highly sensitive but more costly process-specific HCP assays that are usually not initiated until the proof-of-concept stage. But drug developers cannot expect sufficient sensitivity from most commercially available generic assays. For some companies, multiproduct HCP assays could offer a solution to the dilemma. Biopharmaceutical manufacture using genetically modified microorganisms and cell lines is typically associated with contamination by process-related impurities. One of the most important…. ...
This chapter familiarizes readers with tempering and refrigeration treatments and their effect on case-carburized parts. It explains how tempering makes such parts easier to machine, more structurally and dimensionally stable, and more durable in certain applications. It identifies key process parameters and provides test data showing how they affect hardness, yield strength, bending and contact fatigue, and fracture toughness. It also addresses potential problems stemming from process-related factors such as the presence of hydrogen and the effects of aging and grinding. In regard to refrigeration, the chapter explains that it is not uncommon for subzero treatments to be included in the production of carburized parts whether as a standard procedure or optional step. Subzero cooling promotes the transformation of retained austenite to martensite, thereby increasing surface hardness and reducing the propensity of quenched carburized steels to burn and crack during surface grinding. The chapter ...
Research and development in HYDRO Automation are targeted at optimizing the process-related information flow within a hydropower plant.
Principal Investigator:OGAWA Yasutaka, Project Period (FY):1990 - 1992, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Hygiene
Phenol, 4-fluoro-, compd. with acetonitrile (1:1) | C8H8FNO | CID 71385070 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Creative-Proteomics offer cas NA ATROPINE (D3, 98%) 100 UG/ML IN ACETONITRILE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
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The Non-Aqueous Solvent (NAS) CO2 Capture Process is being developed as an advanced, next-generation post-combustion capture technology for CO2 removal from power generation and industrial flue gas streams. The core of the NAS process has been the development of a family of CO2-selective NASs that have the potential to substantially reduce the thermal regeneration energy demand associated with solvent regeneration to ? 2,000 kJt/kg of CO2 captured.
1-Naphthyl acetonitrile 132-75-2 NMR spectrum, 1-Naphthyl acetonitrile H-NMR spectral analysis, 1-Naphthyl acetonitrile C-NMR spectral analysis ect.
After cleaning, the membranes are split longitudinally into strips of varying width, which, when assembled cheap small numbers, according to the diameter required, are twisted under tension, dried, polished, selected and sterilised. Buy Benserazide hydrochloride ппMobile phase в mobilephaseA10gLsolutionoftetrabutylammonium hydrogen Buy cheap Silagra uk R; в mobile Time (min) 0 - 15 15 - 20 20 - 25 phase B acetonitrile Mobile phase Buy cheap Silagra uk (per cent Silaga 100 в 60 60 100 R ; ппMobile phase B (per cent VV) 0 в 40 40 0 C.
Norbert Dentressangle gives 153 new trailers to Carlsberg are being supplied by the Cartwright Group and are expected to deliver significant operational efficiencies.
INEOS Nitriles technology is used by 95% of the worlds acrylonitrile and is the worlds largest manufacture of acetonitrile, with four global sites.
Číslo patentu: E 13665. Dátum: 15.04.2010. Autori: Gelmi Maria Luisa, Fontana Gabriele, Gassa Federico. MPK: C07C 227/32. Značky: derivátov, izoserínových, spôsob, přípravy. Text:. ...diastereoizoméry po jednoduchom kryštalizačnom kroku.0019 Podla tohto spôsobu imín 4 sa najskôr generuje in situ z aldehydu (RCHO) a amínu(RzNHg, kde PhCHZNHZ je výhodný) v acetonitrile pri teplote miestnosti a v prítomnosti molekulámych sít alebo pomocou destilácie azeotropickej zmesi acetonitril/voda. Reakčná teplota je znížená na -30 °C a pridáva sa silylový derivát 3. Potom sa pridáva katalyzátor a zmes sa mieša v priebehu 1 hodiny. Surová.... ...
2.5L Acetonitrile - BioSolv - (10 ppm H20), GL45 Finish *** REAGENTS CANNOT BE ORDER THROUGH SHOPIFY. PLEASE CONTACT [email protected] TO PLACE ORDER. ***
Acetonitrile, hydrogen cyanide and acrolein are known by-products. It is used in the preparation of homo- and copolymers, ... acetonitrile. There are two types of polymers that can be obtained at the end of the synthesis; a physisorbed polymer and a ...
From left to right: 1. water, 2. methanol, 3. ethanol, 4. acetonitrile, 5. dimethylformamide, 6. acetone, 7. ethyl acetate, 8. ...
The dye dissolves very well in water as well as other polar solvents, e.g., Dimethylformamide, acetonitrile. Texas Red, ...
For example, of the ligands acetonitrile, chloride ion and pyridine thepriority number assigned are chloride, 1; acetonitrile,2 ... If there are two possibilities the principle of trans difference is applied). As an example, (acetonitrile)dichlorido(pyridine) ... The ligand priority numbers are, applying the CIP rules: two chlorides of priority number 1 acetonitrile priority 2 pyridine ... acetonitrile)dichlorido(pyridine)platinum(II). The configuration index has two digits. The first digit is the priority number ...
I. Metal ions which have comparable polarographic properties in acetonitrile and in water." J. Am. Chem. Soc. 79 870-874. R. L ... I. M. Kolthoff and J. F. Coetzee (1957). "Polarography in acetonitrile. ...
Like other halogenated acetonitriles, trichloroacetonitrile is produced from organic substances such as algae, humic acids and ... Acetonitrile Trichloroacetic acid Chloral Pollak, Peter; Romeder, Gérard; Hagedorn, Ferdinand; Gelbke, Heinz-Peter. "Nitriles ... Trichloroacetonitrile can be obtained by chlorination of acetonitrile on a zinc, copper and alkaline earth metal halide- ... In contrast, the chlorination of acetonitrile saturated with hydrogen chloride leads to pure trichloroacetonitrile even at 50- ...
"Acetonitrile (EHC 154, 1993)". www.inchem.org. Archived from the original on 2017-05-22. Retrieved 2017-05-03. Akagah B, ... For example, phase I metabolism converts acetonitrile to HOCH2CN, which rapidly dissociates into formaldehyde and hydrogen ...
In acetonitrile its pKa is 24.31. The base is prepared by the reaction of tert-butylamine with a Vilsmeier salt. The latter is ...
Bühl, Michael; Sieffert, Nicolas; Chaumont, Alain; Wipff, Georges (2011-01-03). "Water versus Acetonitrile Coordination to ...
It is freely soluble in water; it is not soluble in acetonitrile. In a dilute aqueous solution, potassium bromide tastes sweet ...
"Acetonitrile Complexes of Selected Transition Metal Cations". Inorganic Syntheses. Inorg. Synth. Inorganic Syntheses. Vol. 28. ...
"Basicity of Phosphanes and Diphosphanes in Acetonitrile". European Journal of Organic Chemistry. 2012 (11): 2167-2172. doi: ...
LiGaH4 reduces acetamide and acetonitrile to ethylamine. Aliphatic acids, aldehydes and ketones are reduced to the ...
Titration of NBu+ 4BF− 4 in acetonitrile solution indicates that HBF4, i.e., HF.BF3, has a pKa of 1.6 in that solvent. Its ... Acetonitrile solutions cleave acetals and some ethers. Many reactive cations have been obtained using fluoroboric acid, e.g. ... Heintz, R. A.; Smith, J. A.; Szalay, P. S.; Weisgerber, A.; Dunbar, K. R. (2002). Homoleptic Transition Metal Acetonitrile ...
Global seasonal distributions of HCN and acetonitrile. 2019. 99th AMS Annual Meeting, American Meteorological Society (AMS). ... "Global seasonal distributions of HCN and acetonitrile". {{cite journal}}: Cite journal requires ,journal= (help) Barth, Mary C ...
... sparingly soluble in isopropyl alcohol and acetonitrile; slightly soluble in diethyl ether; and very slightly soluble in ...
An adduct is also formed with acetonitrile. Dove, Michael F. A.; Berthold Manz; John Montgomery; Gerald Pattenden; Simon A. ...
Hexakis(acetonitrile)rhodium(III) tetrafluoroborate ([Rh(MeCN)6](BF4)3), a yellow solid. Hexakis(acetonitrile)rhenium(II) ... Hexakis(acetonitrile)vanadium(II) tetrachlorozincate ([V(MeCN)6](ZnCl4)2), green Hexakis(acetonitrile)chromium(II) bis( ... acetonitrile)iron(II) bis(tetrakis(pentafluorophenyl)borate) ([Fe(MeCN)6](B(C6F5)4)2, orange Hexakis(acetonitrile)cobalt(II) ... acetonitrile) Tris(pyrazolyl)borate, and Tris(acetonitrile) Tris(pyrazolyl)methane Ruthenium(II) Complexes". Inorganica Chimica ...
Frequently, tetrakis(acetonitrile)copper(I) salts are used. For most applications, reactions can be run at room temperature and ... The reaction is conducted in acetonitrile at room temperature under an atmosphere of air, or less commonly, under an atmosphere ... The reaction is conducted in acetonitrile at room temperature under an atmosphere or air. Catalyst loadings are typically ... The system utilizes 2,2'-bipyridine (bpy), a copper(I) source (typically tetrakis(acetonitrile) copper(I) triflate, ...
The reported pKa in acetonitrile (MeCN) is −3.7. The pKa in DMSO was estimated by the correlation pKaMeCN = 0.98 × pKaDMSO + ...
The complex PaCl4·4CH3CN is formed with acetonitrile. It has a tetragonal crystal structure with the space group I41/amd (space ...
Kaupmees, K.; Kaljurand, I.; Leito, I. (2014). "Influence of Water Content on Basicities in Acetonitrile". J. Solut. Chem. 43 ( ... "Influence of Water Content on the Acidities in Acetonitrile. Quantifying Charge Delocalization in Anions". J. Phys. Chem. A. ...
First, the acetonitrile is oxidized, forming an imine hydroperoxide. Then, this intermediate oxidizes the aniline to ... in acetonitrile at 50 ºC. In this reaction, the pH should be kept around 8, to activate the hydrogen peroxide and avoid too ...
Solvents include trifluoroacetic acid, methanol, dichloromethane, chloroform, and acetonitrile. Many derivatives of ...
Coupling of Carbon Dioxide and Acetonitrile," J. Am. Chem. Soc., 100, 7577 (1978). C. A. Tolman, S. D. Ittel, A. D. English, ...
... methyl nitrate or acetonitrile. Zirconium perchlorate is inert towards carbon tetrachloride, chloroform, and dimethylformamide ...
"Detection of amino acetonitrile in Sgr B2(N)" (PDF). Astronomy and Astrophysics. 482 (1): 179-196. arXiv:0801.3219. Bibcode: ...
It can form complexes with acetonitrile and other compounds. Perry, Dale L.; Phillips, Sidney L. (1995). Handbook of inorganic ...
... acetonitrile)palladium dichloride. The complex is prepared by dissolving PdCl2 in warm benzonitrile. The PhCN ligands are ...
Studies involving acetonitrile showed that the poisoning is mainly due to the hydrocyanic acid liberated in the organism and ... Hunt, Reid (1905-10-01). "The Influence of Thyroid Feeding Upon Poisoning by Acetonitrile". Journal of Biological Chemistry. 1 ...
Acetonitrile. CAS No: 75-05-8. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Acetonitrile. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
Acetonitrile / published under the joint sponsorship of the United Nations Environment Programme, the International Labour ... Evaluates the risks to human health and the environment posed by acetonitrile, a by-product of acrylonitrile manufacture which ...
Acetonitrile was first prepared in 1847 by the French chemist Jean-Baptiste Dumas. Acetonitrile is used mainly as a solvent in ... For example, bis(acetonitrile)palladium dichloride is prepared by heating a suspension of palladium chloride in acetonitrile: ... Production trends for acetonitrile thus generally follow those of acrylonitrile. Acetonitrile can also be produced by many ... Acetonitrile, Geneva: World Health Organization Greenberg, Mark (1999), Toxicological Review of Acetonitrile (PDF), Washington ...
Synonyms: ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide, Acetonitrile. CAS 75-05-8. Molecular Weight 41.05. Browse ... Acetonitrile, Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS ...
Browse a full range of Acetonitrile products from leading suppliers. Shop now at Fisher Scientific for all of your scientific ... Acetonitrile. Acetonitrile. Acetonitrile (CH3CN) is the simplest organic nitrile. It is a commonly used polar aprotic solvent ...
I: Whole body autoradiographic distribution and macromolecular interaction of 2-14C-acetonitrile in mice. Pharmacol Toxicol. ... Toxicology and Carcinogenesis Studies of Acetonitrile in F344/N Rats and B6C3F1 Mice (Inhalation Studies) ... Studies on the mechanism of acetonitrile toxicity. ... Testing Status of Acetonitrile 10242-J. Testing Status of ...
Acronym: ACN CAS Number: 75-05-8 Spec (Assay): 99.9%min Boiling point: 81°C Packaging: 157kg or 25t bulk Application: Polar aprotic solvent Chemical Drawing:
Acetonitrile,ACN,Cyanomethane,Ethyl nitrile,Methyl cyanide; Linear Formula: CH3CN; find Sigma-Aldrich-L010300 MSDS, related ... Wash solution, containing anhydrous acetonitrile (water content ,30 ppm), is used as the overall wash solvent following each ... Ultrapure Acetonitrile; CAS Number: 75-05-8; EC Number: 200-835-2; Synonyms: ...
BiopureTM calibrants are high quality mycotoxin reference materials characterized by independent methods and accompanied by a certificate of analysis created in accordance with ISO Guide 31 and Eurachem guidelines.
Here we report an electro-oxidative C(sp3)-H bond functionalization of acetonitrile with aromatic/aliphatic mercaptans for the ... Direct α-functionalization of acetonitrile, a bulk chemical, is usually limited to its enolate chemistry. Here, the authors ... show an electro-oxidative C(sp3)-H bond functionalization of acetonitrile with thiols to afford tetrasubstituted olefins with ... 4b), while no 2ab was obtained from (4-chlorophenylthio)acetonitrile 5 (Fig. 4c). Therefore, it was confirmed that the first ...
The following pages link to Acetonitrile: Displayed 1 item. View (previous 100 , next 100) (20 , 50 , 100 , 250 , 500) ...
... acetonitrile Remove constraint Subject term: acetonitrile Start Over ... acetonitrile; air; albendazole; chemometrics; chloramphenicol; eggs; enrofloxacin; liquid chromatography; liquid-phase ...
GFS Chemicals is the leading supplier of Acetonitrile, CAS 75-05-8, SKU 17892. GFS Chemicals can handle all your C2H3N needs… ...
3-pyridinylamino)acetonitrile - C7H7N3, synthesis, structure, density, melting point, boiling point ... acetonitrile , density of (3-pyridinylamino)acetonitrile , refractive index of (3-pyridinylamino)acetonitrile ... Tags: melting point of (3-pyridinylamino)acetonitrile , boiling point of (3-pyridinylamino) ...
Acetonitrile, CHROMASOLV LC-MS (2.5Ltr)(BN/EXP). Item #: $34967-2.5L. £343.06. ...
Dynamics of electron ejection on photoionization of trans-stilbene and biphenyl in acetonitrile as observed with femtosecond ... Dynamics of electron ejection on photoionization of trans-stilbene and biphenyl in acetonitrile as observed with femtosecond ...
Title : Acetonitrile in body fluids related to smoking Personal Author(s) : McKee, Herbert C.;Rhoades, John W.;Campbell, John; ...
The coordination geometry of both copper atoms (ON2Cl3) can be described as distorted octa-hedral on account of the aceto- ... Crystal structure and Hirshfeld surface analysis of di-μ-chlorido-bis[(acetonitrile-κN)chlorido(ethyl 5-methyl-1H-pyrazole-3- ... Crystal structure and Hirshfeld surface analysis of di-μ-chlorido-bis[(acetonitrile-κN)chlorido(ethyl 5-methyl-1H-pyrazole-3- ... in aceto-nitrile under ambient conditions. This complex consists of discrete binuclear mol-ecules with a {Cu2(μ2-Cl)2} core, in ...
Calibrant containing Aflatoxin B1 at a concentration of 25μg/mL in Acetonitrile and packaged in 10mL volume. Liquid: Ready-to- ... Solvent: Acetonitrile. Volume: 10 mL. Vial: Chemically-treated amber borosilicate glass vial.. Storage: Product must be stored ... Calibrant containing Aflatoxin B1 at a concentration of 25μg/mL in Acetonitrile and packaged in 10mL volume. ... ":"25µg\/mL Aflatoxin B1 in acetonitrile - In situ","public_title":"In situ","options":["In situ"],"price":15500,"weight":227," ...
QV 633 93AC Acetonitrile / QV 633 93BE Benzene / QV 633 93DI Dichloropropene, dichloropropane and mixtures / QV 633 93ME Methyl ... In laboratories, acetonitrile is widely used in high-performance liquid chromatographic analysis and as a solvent for DNA ... In laboratories, acetonitrile is widely used in high-performance liquid chromatographic analysis and as a solvent for DNA ... Acetonitrile / published under the joint sponsorship of the United Nations Environment Programme, the International Labour ...
2E)-[(2-fluoro-5-methylphenyl)sulfonyl]{[4-(1H-imidazol-1-ylcarbonyl)phenyl]hydrazono}acetonitrile from AK Scientific, in San ... 2E)-[(2-fluoro-5-methylphenyl)sulfonyl]{[4-(1H-imidazol-1-ylcarbonyl)phenyl]hydrazono}acetonitrile. , >90%. Add to Favorites ...
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... acetonitrile. We enable science by offering product choice, services, process excellence and our people make it happen. ...
Acetonitrile CHROMASOLV™, for HPLC, for UV, ≥99.9% (GC), CAS Number: 75-05-8,(34888 Riedel-de Haën).Shop now or request a quote ...
... acetonitrile B&J brand 4 L; acetonitrile absolute over molecular sieve (H2O ,0.001%); Acetonitrile solution; ACETONITRILE ... Therefore, high-purity acetonitrile can be used as a semiconductor cleaning agent. 4. others It Can replace chlorinated ... Acetonitrile can be used as a solvent for the synthesis of vitamin A, cortisone, carbon amine drugs and their intermediates, ... Acetonitrile, often abbreviated as MeCN, is the simplest organic nitrile. It appears as a colorless limpid liquid with an ...
Product Specification: Chemical formula :C2H3N Density:0.982 g/mL at 20 °C molecular weight:41.05 Appearance:colorless and transparent liquid CAS logon number :75-05-8
Diazo acetonitrile was first described by T. Curtius in 1898. Despite its vast potential to streamline organic synthetic ...
  • Acetonitrile is used mainly as a solvent in the purification of butadiene in refineries. (wikipedia.org)
  • Acetonitrile plays a significant role as the dominant solvent used in the manufacture of DNA oligonucleotides from monomers. (wikipedia.org)
  • In laboratories, acetonitrile is widely used in high-performance liquid chromatographic analysis and as a solvent for DNA synthesis and peptide sequencing. (who.int)
  • Acetonitrile is used as a polar aprotic solvent in organic synthesis and butadienepurification, like used as a solvent in spinning fibers and lithium batteries. (allwaychemical.com)
  • Acetonitrile can be used as a solvent for the synthesis of vitamin A, cortisone, carbon amine drugs and their intermediates, and as an active medium solvent for the manufacture of vitamin B1 and amino acids. (allwaychemical.com)
  • Acetonitrile is an organic solvent with strong polarity. (allwaychemical.com)
  • The pharmaceutical industry is the largest end use for acetonitrile and uses it as a reagent, reaction solvent or extraction solvent. (anqore.com)
  • Acetonitrile is used as a polar aprotic solvent in organic synthesis and for the purification of butadiene. (pw.live)
  • Acetonitrile is mainly used as solvent. (yuanfarchemical.com)
  • This compound acts as a fluorescent sensor suitable for detection of small inorganic cations (lithium, sodium, barium, calcium, magnesium, cadmium, lead and zinc) in strongly polar solvent (acetonitrile). (springer.com)
  • The use of acetonitrile as the crystallization solvent was essential for obtaining good-quality crystals. (uwc.ac.za)
  • Acetonitrile, also known as ethanenitrile or methyl cyanide, refers to a lethal and colorless solvent. (digitalbuzznews.com)
  • Acetonitrile is widely available in the derivative and solvent variants. (digitalbuzznews.com)
  • The growing product adoption as a solvent in the pharmaceutical industry for manufacturing antibiotics and insulin is primarily driving the India acetonitrile market. (digitalbuzznews.com)
  • Acetonitrile is used as a medium-polarity and aprotic solvent in the refinement and natural synthesis of butadiene. (resistancephl.com)
  • Besides this, several product innovations, including the launch of aqueous acetonitrile, which is used as an extraction solvent to synthesize pesticides and fertilizers, are further propelling the product demand. (resistancephl.com)
  • The reagents used for HPLC analysis were methanol from Junsei, acetonitrile from JT-BAKER, water (Tertiary distilled water), and DMSO. (medsci.org)
  • Subsequent elution with 1.0 vol % acetonitrile in methanol causes an instantaneous color change from blue to red and rapid elution. (orgsyn.org)
  • Excellent recovery was observed when the SPE column was eluted with acetonitrile or methanol. (cdc.gov)
  • The syringe was rinsed with methanol and acetonitrile multiple times to remove residual analytes and IL. (foodnavigator.com)
  • With a dipole moment of 3.92 D, acetonitrile dissolves a wide range of ionic and nonpolar compounds and is useful as a mobile phase in HPLC and LC-MS. It is widely used in battery applications because of its relatively high dielectric constant and ability to dissolve electrolytes. (wikipedia.org)
  • Fisher Chemical Acetonitrile, HPLC gradient grade, reag. (lab-shop.com)
  • Reverse phase-high pressure liquid chromatography (RP-HPLC) with an acetonitrile-water mixture as the eluent is widely used for purification of proteins. (illinois.edu)
  • The separation of acetonitrile (ACN) in RP-HPLC eluent is important for protein recovery. (illinois.edu)
  • Dhamole, PB, Mahajan, P & Feng, H 2010, ' Sugaring out: A new method for removal of acetonitrile from preparative RP-HPLC eluent for protein purification ', Process Biochemistry , vol. 45, no. 10, pp. 1672-1676. (illinois.edu)
  • The samples were analyzed by reverse phase (C18) HPLC using a binary mobile phase gradient of acetonitrile/water. (cdc.gov)
  • Eco-Friendly RP-HPLC - Replacing Acetonitrile w. (chromatographytoday.com)
  • Acetonitrile is a common two-carbon building block in organic synthesis of many useful chemicals, including acetamidine hydrochloride, thiamine, and α-napthaleneacetic acid. (wikipedia.org)
  • Acetonitrile, for DNA synthesis (max. (sigmaaldrich.com)
  • Here we report an electro-oxidative C(sp 3 )-H bond functionalization of acetonitrile with aromatic/aliphatic mercaptans for the synthesis of sulfur-containing β-enaminonitrile derivatives. (nature.com)
  • Increased consumption of acetonitrile from the pharmaceutical industry and demand as raw material for another chemical synthesis. (webspangle.com)
  • In addition, this mixture can be encountered during the acetonitrile synthesis proposed from bioethanol and bioethylene, so these multiphase equilibria govern the separation and purification of acetonitrile in specific reactors that allow the recovery of ammonium bicarbonate as a valuable byproduct. (unimi.it)
  • Abe, T , Noda, K & Sawada, D 2021, ' Synthesis of α-substituted indolylacetamide using acetonitriles as acetamide enolate equivalents through O-transfer reactions ', Chemical Communications , vol. 57, no. 61, pp. 7493-7496. (elsevier.com)
  • With years of experience in production 99% Compound Synthesis Acetonitrile , Qingdao Hisea Chem Co., Ltd. can supply a wide range of 99% Compound Synthesis Acetonitrile . (hiseachem.com)
  • 99% Compound Synthesis Acetonitrile can meet many applications, if you need, please get our online timely service about 99% Compound Synthesis Acetonitrile . (hiseachem.com)
  • In addition to the product list below, you can also customize your own unique 99% Compound Synthesis Acetonitrile according to your specific needs. (hiseachem.com)
  • Singh S.: Excess Gibbs for binary mixtures of acetonitrile with acetic acid, propionic acid, isobutyric acid, and trimethylacetic acid. (ddbst.de)
  • Acetonitrile can be recycled easily from both anhydrous and aqueous wastes. (webspangle.com)
  • Finally, the advantages of the different methods to the determination of pK(a) values of nine polyphenolic acids have been described in order to verify the applicability of the proposed methods in aqueous and acetonitrile-water media. (sdu.edu.tr)
  • The effect of acetonitrile (ACN) on the micellization of a cationic surfactant, cetyltrimethylammo-nium bromide (CTAB), in aqueous solutions at different temperatures was studied. (ac.rs)
  • TY - JOUR AU - Janošević-Ležaić, Aleksandra AU - Pejić, Nataša AU - Goronja, Jelena AU - Pavun, Leposava AU - Ðikanović, Danijela AU - Malenović, Anđelija PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4056 AB - The effect of acetonitrile (ACN) on the micellization of a cationic surfactant, cetyltrimethylammo-nium bromide (CTAB), in aqueous solutions at different temperatures was studied. (ac.rs)
  • The present invention relates to improved processes to recover acetonitrile from a diluted aqueous low grade acetonitrile feedstock. (freepatentsonline.com)
  • Acetonitrile as raw material for manufacturing agriculture pesticides and aromatizers is boosting the acetonitrile market. (webspangle.com)
  • The Smoluchowski and Collins-Kimball models, which assume reaction at a single distance, are able to fit the data collected in acetonitrile solutions reasonably well, but not the data in the IL solvents. (elsevier.com)
  • Columns were eluted with acetonitrile-water gradients containing 0.1 % formic acid in both solvents. (mfa.org)
  • Acetonitrile, gradient grade for liquid chromatography LiChrosolv ® Reag. (sigmaaldrich.com)
  • The salting out of acetonitrile from water in the presence of ammonium bicarbonate was studied at atmospheric pressure from 4 to 35 °C. The coexisting phases were analyzed independently with H1 nuclear magnetic resonance, ion chromatography, calorimetry, and titrations. (unimi.it)
  • The partition coefficients' application in the hexane-acetonitrile system as an additional identification feature of polyaromatic hydrocarbons in the review gas chromatography-mass spectrometry analysis of delayed coking gas oils has been considered. (colab.ws)
  • Without question, the current acetonitrile shortage has become the hottest topic in the chromatography world in recent memory. (chromatographyonline.com)
  • Acetonitrile, often abbreviated MeCN (methyl cyanide), is the chemical compound with the formula CH3CN and structure H3C−C≡N. This colourless liquid is the simplest organic nitrile (hydrogen cyanide is a simpler nitrile, but the cyanide anion is not classed as organic). (wikipedia.org)
  • Acetonitrile has a free electron pair at the nitrogen atom, which can form many transition metal nitrile complexes. (wikipedia.org)
  • Acetonitrile (CH3CN) is the simplest organic nitrile. (fishersci.com)
  • Acetonitrile, often abbreviated as MeCN, is the simplest organic nitrile. (allwaychemical.com)
  • Acetonitrile can undergo typical nitrile reactions and is used to prepare many typical nitrogen-containing compounds. (allwaychemical.com)
  • In view of the hazards of poisoning, the report concludes that acetonitrile and mixtures containing this chemical should be clearly labelled with a warning about danger of poisoning. (who.int)
  • The pK(a) values of nine polyphenolic acid substances in water and acetonitrile-water mixtures using potentiometric, spectrophotometric, and liquid chromatographic (LC) measurements, have been determined. (sdu.edu.tr)
  • Synonyms:2-(3-Chlorophenyl)ethanenitrile;Acetonitrile, (m-chlorophe. (chemnet.com)
  • The IMARC Group provides extensive analysis of the India acetonitrile industry covering the market trends, investment opportunities, growth trends, statistics, and industry prospects. (digitalbuzznews.com)
  • The India acetonitrile market is expected to exhibit a CAGR of 6.7% during 2022-2027. (digitalbuzznews.com)
  • In addition to this, the elevating product requirement in the chemical processing industry, along with its rising utilization for recrystallization of drugs, is expected to fuel the India acetonitrile market over the forecasted period. (digitalbuzznews.com)
  • Looking forward, IMARC Group expects the India acetonitrile market to continue its robust growth during the forecast period (2022-2027). (digitalbuzznews.com)
  • Steady-state and time-resolved measurements of the reductive fluorescence quenching of five fluorophores ("F") by six quenchers ("Q" electron donors) are reported in acetonitrile and two ionic liquids, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide and trihexyl(tetradecyl)phosphonium bis(trifluoromethylsulfonyl)amide. (elsevier.com)
  • Apeel Sciences provides specifications for monoglyceride (≥ 91%) and diglyceride (≤ 7%) levels as well as limits for ethyl acetate (≤ 100 milligrams per kilogram (mg/kg)), acetonitrile (≤ 5 mg/kg), toluene (≤ 5 mg/kg), hexane (≤ 25 mg/kg), and individual heavy metals (including Lead (≤ 1 mg/kg), Palladium (≤ 3 mg/kg) and Arsenic (≤ 0.2 mg/kg)), in the finished product. (fda.gov)
  • Growing investments by the government for improving medical infrastructure together with an increase in demand from research organizations has further boosted demand for acetonitrile market in these regions. (webspangle.com)
  • Moreover, the continuous launch of various favorable initiatives by the Indian government, including the National Food Security Mission (NFSM), is leading to the escalating demand for acetonitrile-based agrochemicals. (digitalbuzznews.com)
  • Moreover, there is an escalating demand for acetonitrile in the automotive sector for producing acrylonitrile butadiene styrene (ABS) plastic, which has enhanced chemical resistance and mechanical strength. (resistancephl.com)
  • The separation of acetonitrile and water for extraction purposes, instead, is often obtained with other ammonium salts. (unimi.it)
  • 2022-12-10 (Acetonitrile)[(2-biphenyl)di-tert-butylphosphine]gold(I) hexafluoroantimonate,casno 866641-66-9,Formula:C22H30AuF6NPSb.Serving CMO & CDMO. (cks.one)
  • So, in this work, the molar conductivities of the ionic liquids, 1-alkyl-3-methylimidazolium bromide, [C n MIm]Br (n = 4, 6 and 8) in various concentrations of aspirin (ASA) in acetonitrile (MeCN) solutions are determined in very diluted region of ILs, (molality less than 0.01 mol kg -1 ) and at 298.15 K. The obtained conductivity data were analyzed by low concentration Chemical Model (lcCM) of conductance equation. (physchemres.org)
  • We investigate the formation of positively charged fragments of acetonitrile (CH3CN) in intense 800 nm, 50 fs pulses of radiation using a reflectron time-of-flight (TOF) ion mass spectrometer. (semanticscholar.org)
  • Onset of symptoms after exposure to nitriles (acetonitrile and/or propionitrile) may be significantly delayed. (medscape.com)
  • Nitriles includes acrylonitrile, which is used to make carbon fibre, acrylic clothing, soft toys and upholstery, together with acetonitrile and. (ineos.com)
  • INEOS Nitriles is the world's largest producer of acrylonitrile & acetonitrile. (ineos.com)
  • The acetonitrile extraction eliminates the need for chromatographic purification of vitamin D prior to its actual assay. (medscape.com)
  • We introduce readily available ammonium hemiaminals as O-transfer reagents and commercially available acetonitriles as a primary amide enolate precursor. (elsevier.com)
  • [ 11 ] In general, these assays depend on an antibody that recognizes 25(OH)D2 and 25(OH)D3 in equimolar proportions and the competitive displacement of tracer 25(OH)D (25(OH)D that has been tagged with a radioactive isotope such as 125-I or a chemiluminescent ligand) by acetonitrile extracted samples. (medscape.com)
  • Acetonitrile is a colorless liquid that's characterized by an aromatic-fruity odor. (pw.live)
  • Five companies collected data of five substances (acetonitrile, bis-phenol A, chlorobenzene, dichloromethane, pyridine) in their 17 Swiss facilities for the reporting year 1995. (mapcruzin.com)
  • Acetonitrile is widely utilized as a starting material to synthesize vitamin A and B1, cortisones, carbonate drugs, amino acids, etc. (resistancephl.com)
  • Vinogorova, V.T., GC Identification of organic compounds based on partition coefficients of their TMS derivatives in a hexane-acetonitrile system and retention indices, Anal. (chemspider.com)
  • A hexadecameric supramolecule containing four stacked tetramers is formed in acetonitrile aided by higher potassium concentrations. (nih.gov)
  • The chromatographic separation was performed on an Agilent Eclipse Plus C18 column (2.1 mm×100 mm, 3.5 μ m) using gradient elution with mobile phase consisting of acetonitrile and water (containing 0.1% formic acid). (hindawi.com)
  • The sample pretreatment consisted of protein precipitation with acetonitrile using a small plasma volume of 50 μL. (nih.gov)
  • North America and Asia-Pacific are expected to form the largest market for acetonitrile market. (webspangle.com)
  • Cases of acetonitrile poisoning in humans (or, to be more specific, of cyanide poisoning after exposure to acetonitrile) are rare but not unknown, by inhalation, ingestion and (possibly) by skin absorption. (wikipedia.org)
  • The mouse LC50 value of 2,693 ppm for a 60 minute exposure to acetonitrile [Willhite 1981] was selected as the basis for the IDLH value. (cdc.gov)
  • Solvation of fluoro-acetonitrile in water by 2D-IR spectroscopy: A combined experimental-computational study. (mpg.de)
  • Salicylidene acetonitrile-functionalized poly(methyl methacrylate) crown ethers: soluble and dynamic molecular switches. (richonline.club)
  • If accidentally swallowed, chemicals found in acetonitrile-based products that are used to remove artificial nails can produce cyanide when metabolized by the body. (cdc.gov)
  • Solutions with felodipine were diluted with the mobile phase acetonitrile/0.01 M phosphate buffer pH 4.5 (70/30). (pharmtech.com)
  • Lyophilized from 5% (v/v) acetonitrile/H₂O. (genetex.com)
  • NIOSH Immediately Dangerous to Life or Health value for Acetonitrile, Chloroacetonitrile, Methacrylonitrile, and Nitrogen Dioxide. (cdc.gov)
  • The purpose of these technical reports is to document the scientific basis of the NIOSH immediately dangerous to life or health (IDLH) value for acetonitrile, chloroacetonitrile, methacrylonitrile, and nitrogen dioxide. (cdc.gov)
  • Acetonitrile : water (55:45) was used as a mobile phase. (europa.eu)
  • The dinuclear complexes [Rh(μ-Cl)(IPr)(η2-olefin)]2 {IPr = 1,3-bis-(2,6-diisopropylphenyl)imidazol-2-carbene} have been reacted with different combinations of ligands including pyridine, acetonitrile, 2-pyridylacetonitrile, triphenylphosphine, tricyclohexylphosphine, carbon monoxide or molecular oxygen. (univaq.it)
  • In contrast, acetonitrile is more labile than pyridine but is able to form complexes coordinated cis-to-IPr. (univaq.it)
  • Specifically, acetonitrile is fed into the top of a distillation column filled with hydrocarbons including butadiene, and as the acetonitrile falls down through the column, it absorbs the butadiene which is then sent from the bottom of the tower to a second separating tower. (wikipedia.org)
  • Therefore, high-purity acetonitrile can be used as a semiconductor cleaning agent. (allwaychemical.com)
  • NAS 2014] indicate that chloroacetonitrile is 10 times more toxic than acetonitrile. (cdc.gov)
  • A modifying factor of 10 is applied to the IDLH value to account for the greater potency of chloroacetonitrile compared to the potency of the surrogate, acetonitrile, resulting in an IDLH value of 14 ppm. (cdc.gov)
  • Pharmaceutical application segment is projected to lead the acetonitrile market the increased use of acetonitrile in the pharmaceutical industry for manufacturing vitamin B1 and sulfa pyrimidine. (webspangle.com)
  • The increasing product adoption in the pharmaceutical industry is primarily driving the acetonitrile market across Japan. (resistancephl.com)
  • needs update] Acetonitrile has only modest toxicity in small doses. (wikipedia.org)
  • Studies on the mechanism of acetonitrile toxicity. (nih.gov)
  • Concerning the effects of acetonitrile on organisms in the environment, the report concludes that this chemical has low toxicity due to its rapid volatization and biodegradation. (who.int)