(1/10) Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase.

Acetohexamide (AH) is reduced to its alcohol metabolite by carbonyl reductase. We have previously shown that carbonyl reductase present in the liver microsomes of rats is a male-specific and androgen-dependent enzyme. In the present study, the role of microsomal carbonyl reductase in the pharmacokinetics of AH was examined in male Wistar-Imamichi (WI) and Sprague-Dawley (SD) rats after its intravenous administration. AH was eliminated more slowly from plasma in the WI strain, which lacks most of the microsomal carbonyl reductase, than in the SD strain. Furthermore, several pharmacokinetic parameters were derived from the data for the plasma concentrations of AH. The plasma clearance (CL(p)) of AH (72.8+/-11.2 ml/h/kg) in male WI rats was significantly smaller than that (105.5+/-11.1 ml/h/kg) in male SD rats. Testectomy caused a marked decrease, from 105.5+/-11.1 to 44.3+/-11.8 ml/h/kg, in the CL(p) of AH in male SD rats. These results indicate that microsomal carbonyl reductase plays a critical role in the differential pharmacokinetics of AH in male WI and SD rats.  (+info)

(2/10) Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography.

 (+info)

(3/10) Chromatographic analysis of acetohexamide binding to glycated human serum albumin.

 (+info)

(4/10) Detection of heterogeneous drug-protein binding by frontal analysis and high-performance affinity chromatography.

 (+info)

(5/10) In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.

 (+info)

(6/10) Mechanism of interference with the Jaffe reaction for creatinine.

We investigated the mechanism of the Jaffe reaction for determination of creatinine by studying the spectrophotometric, kinetic, and equilibrium properties of the reaction of picrate with creatinine and with cyclic and aliphatic ketones. Absorbance spectra for the reaction products of picrate with all the ketones were superimposable with that of creatinine (Amax, 490 nm). Cyclic ketones not containing nitrogen had a molar absorptivity less than half that of creatinine and equilibrium constants approximately 0.01 that of creatinine. Aliphatic ketones, except for benzylacetone, had molar absorptivities similar to that of creatinine, but all of these compounds had equilibrium constants approximately a tenth or less that of creatinine. The common structure for all of the compounds reacting with picrate is the carbonyl group. The variable magnitude of interference for aliphatic and cyclic ketones is ascribable to the different rate constants, molar absorptivities, and equilibrium constants as compared with creatinine. Structures adjacent to the carbonyl group significantly affect the absorptivity and equilibrium constant, but steric hindrance is the major factor affecting the rate of reaction. We postulate that the carbonyl group is required for the Jaffe reaction, and we suggest a mechanism for the reaction.  (+info)

(7/10) The effect of sulfonylurea drugs on rabbit myocardial contractility, canine purkinje fiber automaticity, and adenyl cyclase activity from rabbit and human hearts.

Long-term clinical studies have associated tolbutamide therapy with an increased incidence of cardiovascular deaths. The effects of this and other sulfonylurea drugs on contractility and rate of isolated rabbit atria, automaticity of isolated dog Purkinje fibers, and adenyl cyclase activity in particulate preparations of rabbit and human hearts were studied. At concentrations that are attained clinically, tolbutamide (10 mg/100 ml) increased contractility of driven rabbit atria to 124+/-5% of control, acetohexamide (3.9 mg/100 ml) to 140+/-5%, chlorpropamide (8.3 mg/100 ml) to 139+/-6%, and tolazamide (3.1 mg/100 ml) to 119+/-6%. These effects were accentuated in the presence of 2.5 x 10(-4) M theophylline and were not blocked by 1 x 10(-5) M propranolol. Adenyl cyclase was activated by each of these drugs at concentrations below those which increase contractility. The drugs also increased the rate and slope of phase 4 depolarization in spontaneously beating Purkinje fibers, but did not alter the spontaneous rate of isolated rabbit atria. Since inotropic and chronotropic stimulation can be deleterious in some clinical settings, these findings may be of significance in interpretation of cardiovascular mortality data.  (+info)

(8/10) Purification and catalytic properties of a novel acetohexamide-reducing enzyme from rabbit heart.

An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration and nondenaturing PAGE and 28 kDa by SDS-PAGE, suggesting that the enzyme is composed of four identical-size subunits. 4-Benzoyl-pyridine and p-nitroacetophenone, typical substrates of carbonyl reductase [EC 1.1.1.184], were not reduced by the enzyme. Of drugs with a ketone group tested, only acetohexamide was a good substrate of the enzyme. the enzyme effectively reduced analogs substituted with various alkyl groups instead of the cyclohexyl group in acetohexamide, although it had little or no ability to reduce analogs substituted with various alkyl groups instead of the methyl group in acetohexamide. The enzyme was inhibited not only by quercetin, a well-known inhibitor of carbonyl reductase, but also by phenobarbital, a potent inhibitor of aldehyde reductase [EC 1.1.1.2]. These results indicate that the enzyme purified from rabbit heart is a novel enzyme responsible for the reduction of acetohexamide and its analogs.  (+info)

*  Acetohexamide
For this reason, acetohexamide is not used to treat diabetes mellitus type 1. Oral hypoglycemic drugs, including acetohexamide ... Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. ... Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, ...
*  Sulfonylurea
First generation drugs include acetohexamide, carbutamide, chlorpropamide, glycyclamide (tolhexamide), metahexamide, tolazamide ...
*  Glossary of diabetes
Acetohexamide A pill taken to lower the level of glucose (sugar) in the blood. People with Type 2 diabetes may take these pills ...
*  Tall Man lettering
acetoHEXAMIDE buPROPion vs. busPIRone chlorproMAZINE vs. chlorproPAMIDE clomiPHENE vs. clomiPRAMINE cycloSERINE vs. ...
*  Anti-diabetic medication
First-generation agents tolbutamide acetohexamide tolazamide chlorpropamide Second-generation agents glipizide glyburide or ...
*  List of MeSH codes (D02)
... acetohexamide MeSH D02.886.590.795.204 --- carbutamide MeSH D02.886.590.795.283 --- chlorpropamide MeSH D02.886.590.795.475 ... acetohexamide MeSH D02.948.828.204 --- carbutamide MeSH D02.948.828.283 --- chlorpropamide MeSH D02.948.828.475 --- gliclazide ...
*  ATC code A10
A10BB08 Gliquidone A10BB09 Gliclazide A10BB10 Metahexamide A10BB11 Glisoxepide A10BB12 Glimepiride A10BB31 Acetohexamide ...
*  List of causes of hypoglycemia
3-alpha-hydroxyacyl-CoA dehydrogenase deficiency 3-Methylcrotonyl-CoA carboxylase deficiency ACAD9 deficiency Acetohexamide ...
*  List of drugs: Ac
... acetohexamide acetohexamide (INN) acetohydroxamic acid (INN) acetophenazine (INN) acetorphine (INN) Acetoxyl acetryptine (INN) ...
*  Sulfonamide (medicine)
Acetohexamide Carbutamide Chlorpropamide Glibenclamide (glyburide) Glibornuride Gliclazide Glyclopyramide Glimepiride Glipizide ...
Acetohexamide |  Reference Library - Drugs | Drugs | Healthways, Inc.  Acetohexamide | Reference Library - Drugs | Drugs | Healthways, Inc.
Do not stop taking acetohexamide without consulting your doctor. Prolonged Use. The dosage may need to be adjusted with ... Acetohexamide may pass into breast milk; caution is advised. Consult your doctor if you are considering breast feeding. ... Acetohexamide is not usually given during pregnancy. Insulin is generally the treatment of choice for pregnant diabetic ... The effects of acetohexamide can be altered by anti- coagulants, antidepressants, aspirin, over-the-counter cold preparations ...
more infohttp://www.wholehealthmd.com/main/drugs/acetohexamide-141.aspx
acetohexamide | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY  acetohexamide | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
acetohexamide ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
more infohttp://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=structure&ligandId=6793
Allina Hospitals & Clinics - Acetohexamide (By mouth)  Allina Hospitals & Clinics - Acetohexamide (By mouth)
Acetohexamide (By mouth). Acetohexamide (a-seet-oh-HEX-a-mide). Lowers the level of sugar in your blood. Used together with ... You should not use this medicine if you have had an allergic reaction to acetohexamide or other diabetes drugs such as ... There are many other medicines that you should not use together with acetohexamide. This includes nonprescription (over-the- ...
more infohttps://www.allinahealth.org/CCS/doc/Thomson%20DrugNotes/45/4952.htm
Acetohexamide - Wikipedia  Acetohexamide - Wikipedia
For this reason, acetohexamide is not used to treat diabetes mellitus type 1. Oral hypoglycemic drugs, including acetohexamide ... Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. ... Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, ...
more infohttps://en.wikipedia.org/wiki/Acetohexamide
Acetohexamide  - Side effect(s)  Acetohexamide - Side effect(s)
Read the side effects of Acetohexamide as described in the medical literature. In case of any doubt consult your doctor or ... Acetohexamide - Information. Acetohexamide is used to treat type 2 diabetes mellitus for controlling the high blood sugar level ... Side effect(s) of Acetohexamide Read the side effects of Acetohexamide as described in the medical literature. In case of any ...
more infohttps://www.medindia.net/drugs/medication-side-effects/acetohexamide.htm
Acetohexamide 10667-R  Acetohexamide 10667-R
Testing Status of Acetohexamide 10667-R. CASRN: 968-81-0. Formula: C15-H20-N2-O4-S. Synonyms/Common Names. *4-Acetyl-N-(( ...
more infohttps://ntp.niehs.nih.gov/testing/status/agents/ts-10667-r.html
Acetohexamide | definition of acetohexamide by Medical dictionary  Acetohexamide | definition of acetohexamide by Medical dictionary
... acetohexamide explanation free. What is acetohexamide? Meaning of acetohexamide medical term. What does acetohexamide mean? ... Looking for online definition of acetohexamide in the Medical Dictionary? ... acetohexamide. Also found in: Dictionary, Thesaurus, Wikipedia.. Related to acetohexamide: acetazolamide, glyburide, tolazamide ... acetohexamide,. n brand names: Dimelor, Dymelor; drug class: sulfonylurea; antidiabetic; action: causes functioning β cells in ...
more infohttp://medical-dictionary.thefreedictionary.com/acetohexamide
Acetohexamide - toxicity, ecological toxicity and regulatory information  Acetohexamide - toxicity, ecological toxicity and regulatory information
Acetohexamide Illinois EPA list. Keith list. Colborn list. Benbrook list. Danish Inert list. EU list. Not Listed. Not Listed. ... Acetohexamide WHO Acute Hazard. TRI Acute Hazard. Material Safety Data Sheets. Acute rating from U.S. EPA product label. U.S. ... Acetohexamide CA Prop 65 Developmental Toxin. U.S. TRI Developmental Toxin. CA Prop 65 Female Reproductive Toxin. CA Prop 65 ... Acetohexamide IARC Carcinogens. U.S. NTP Carcinogens. California Prop 65 Known Carcinogens. U.S. EPA Carcinogens. TRI ...
more infohttp://pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PRI787
acetohexamide - meddic  acetohexamide - meddic
Acetohexamide medical facts from Drugs.com Physician reviewed acetohexamide patient information - includes acetohexamide ... Acetohexamide - Drugs.com Acetohexamide is a medicine available in a number of countries worldwide. A list of US medications ... Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently.[1 ... Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, ...
more infohttp://meddic.jp/acetohexamide
acetoHEXAMIDE | Daviss Drug Guide  acetoHEXAMIDE | Davis's Drug Guide
www.drugguide.com/ddo/view/Davis-Drug-Guide/51007/all/acetoHEXAMIDE. Quiring C, Sanoski CA, Vallerand AH. AcetoHEXAMIDE. ... acetoHEXAMIDE is a topic covered in the Davis's Drug Guide. To view the entire topic, please sign in or purchase a subscription ... TY - ELEC T1 - acetoHEXAMIDE ID - 51007 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - ... "AcetoHEXAMIDE." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. ...
more infohttps://www.drugguide.com/ddo/view/Davis-Drug-Guide/51007/all/acetoHEXAMIDE
Dymelor Drug Interactions - Drugs.com  Dymelor Drug Interactions - Drugs.com
Dymelor (acetohexamide) disease Interactions. There are 5 disease interactions with Dymelor (acetohexamide) which include:. * ... Dymelor (acetohexamide) alcohol/food Interactions. There is 1 alcohol/food interaction with Dymelor (acetohexamide) ... Check for interactions with Dymelor (acetohexamide). Type in a drug name and select a drug from the list. ... A total of 903 drugs (5914 brand and generic names) are known to interact with Dymelor (acetohexamide). ...
more infohttps://www.drugs.com/drug-interactions/acetohexamide,dymelor.html
Drug Information  Drug Information
Acetohexamide Acetohexamide is used to treat type 2 diabetes mellitus for controlling the high blood sugar level together with ...
more infohttps://www.medindia.net/doctors/drug_information/home.asp
First Generation Sulfonylurea  First Generation Sulfonylurea
Acetohexamide, acetohexamide (medication), Acetohexamide [Chemical/Ingredient], acetoHEXAMIDE, acetohexamide, Acetylcholine ... Acetohexamide - chemical, Acetylcholine chloride - chemical, Acetohexamide (product), Acetohexamide (substance), ACETOHEXAMIDE ... Ontology: Acetohexamide. (C0000992) Definition (NCI) An intermediate-acting, first-generation sulfonylurea with hypoglycemic ... Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide. Definition (MSH) A sulfonylurea ...
more infohttp://www.fpnotebook.com/Endo/Pharm/FrstGnrtnSlfnylr.htm
Amobarbital 0.1 mg/ml in Methanol- CAS Number 57-43-2  Amobarbital 0.1 mg/ml in Methanol- CAS Number 57-43-2
Acetohexamide. 10 mg. LGCFOR1726.00. Ajouter au panier Acetomenaphthone (Menadiol Diacetate). 10 mg. LGCFOR1730.00. Ajouter au ...
more infohttps://www.lgcstandards.com/FR/fr/Amobarbital-0-1-mg-ml-in-Methanol/p/LGCAMP1353.00-02
AM2201 N-(3-fluoropentyl) isomer- CAS Number null  AM2201 N-(3-fluoropentyl) isomer- CAS Number null
Acetohexamide. 10 mg. LGCFOR1726.00. Add to basket Acetomenaphthone (Menadiol Diacetate). 10 mg. LGCFOR1730.00. Add to basket ...
more infohttps://www.lgcstandards.com/FR/en/AM2201-N-3-fluoropentyl-isomer/p/CAY-9001030-100UG
Glossary of Pharmacology Stubs related terms, short phrases and...  "Glossary of Pharmacology Stubs" related terms, short phrases and...
Acetohexamide. *Acetohexamide is a sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose ... ACETOHEXAMIDE. ACIDIFIER. ACRIFLAVINE. ACTINOMYCIN. ACTIVE INGREDIENT. ADVERSE EVENT. AFRIN. ALAMETHICIN. ALBENDAZOLE. ... Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently.. ... For this reason, acetohexamide is not used to treat Diabetes mellitus type 1.. ...
more infohttp://keywen.com/en/GLOSSARY_OF_PHARMACOLOGY_STUBS
Lamotrigine - Wikipedia  Lamotrigine - Wikipedia
Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs.[60] This may suppress the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters in the CNS.[61] It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[62] but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties.[63] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes. It also blocks L-, N-, and P-type calcium channels and ...
more infohttps://en.wikipedia.org/wiki/Lamotrigine
Domperidone - Wikipedia  Domperidone - Wikipedia
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
more infohttps://en.wikipedia.org/wiki/Domperidone
Whatever you wanted to know about health - we will tell you that and even more  Whatever you wanted to know about health - we will tell you that and even more
New Warning for Acetohexamide Users October 18, 2019. Allison. Children's health No Comments ...
more infohttp://coconutoilbenefits.biz/page/3/
Antidiabetic Drugs | Encyclopedia.com  Antidiabetic Drugs | Encyclopedia.com
Antidiabetic Drugs Definition Antidiabetic drugs are medicines that help control blood sugar [1] levels in people with diabetes mellitus (sugar diabetes).
more infohttps://www.encyclopedia.com/medicine/drugs/pharmacology/antidiabetic-drugs