Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.Annona: A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain acetogenins and benzoquinazoline and other alkaloids.Annonaceae: The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Uvaria: A plant genus of the family ANNONACEAE. Members contain uvarigrin, uvarigrandin, chamuvaritin and other acetogenins and benzylisoquinoline alkaloids.Benzethonium: Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.Lactones: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.Laurencia: A genus of RED ALGAE in the family Rhodomelaceae. Some species are a rich source of chlorine-and bromine-containing metabolites which show significant antibacterial activity.Electron Transport Complex I: A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Medicine, Traditional: Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.United Nations: An international organization whose members include most of the sovereign nations of the world with headquarters in New York City. The primary objectives of the organization are to maintain peace and security and to achieve international cooperation in solving international economic, social, cultural, or humanitarian problems.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Ethnobotany: The study of plant lore and agricultural customs of a people. In the fields of ETHNOMEDICINE and ETHNOPHARMACOLOGY, the emphasis is on traditional medicine and the existence and medicinal uses of PLANTS and PLANT EXTRACTS and their constituents, both historically and in modern times.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Asimina: A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain asitrocin, asitrilobins, and other tetrahydrofuran acetogenins.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Alkanes: The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)Evolution, Chemical: Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Organic Chemistry Processes: The reactions, changes in structure and composition, the properties of the reactions of carbon compounds, and the associated energy changes.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Subtilisins: A family of SERINE ENDOPEPTIDASES isolated from Bacillus subtilis. EC 3.4.21.-Venous Thrombosis: The formation or presence of a blood clot (THROMBUS) within a vein.Vitreous Detachment: Detachment of the corpus vitreum (VITREOUS BODY) from its normal attachments, especially the retina, due to shrinkage from degenerative or inflammatory conditions, trauma, myopia, or senility.Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Flavonoids: A group of phenyl benzopyrans named for having structures like FLAVONES.Medicine, Ayurvedic: The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.Scattering, Radiation: The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Medicine, Chinese Traditional: A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.Herbal Medicine: The study of medicines derived from botanical sources.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Cyclohexenes: Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.Cyclohexanes: Six-carbon alicyclic hydrocarbons.Vinyl CompoundsNonheme Iron Proteins: Proteins, usually acting in oxidation-reduction reactions, containing iron but no porphyrin groups. (Lehninger, Principles of Biochemistry, 1993, pG-10)Charcoal: An amorphous form of carbon prepared from the incomplete combustion of animal or vegetable matter, e.g., wood. The activated form of charcoal is used in the treatment of poisoning. (Grant & Hackh's Chemical Dictionary, 5th ed)Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Xylopia: A plant genus of the family ANNONACEAE. Members contain DITERPENES.Dictionaries, MedicalPolyalthia: A plant genus of the family ANNONACEAE. Members contain 8-oxopolyalthiaine.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Inhibitory activities of three annonaceous acetogenins on NADH oxidase of chicken liver mitochondria. (1/25)
Annonaceous acetogenins (ACG) are natural products found in the plant family Annonaceae and which strongly inhibited mitochondrial complex I. The inhibition of NADH oxidase of chicken liver mitochondria by three different structural ACG was studied here, and ACG was shown to have potent inhibitory activities similar to rotenone for NADH oxidase. The IC(50) values indicated that bis-adjacent tetrahydrofuran (THF) type squamocin C was more potent than non-adjacent bis-THF type squamostatin B, and the latter was more potent than non-THF type compound 1 in the assay. The roles of structural factors of ACG such as the terminal gamma-lactone, the features of other ring moieties and hydroxyl groups, as well as the alkyl chain were simply discussed in this study. (+info)Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: role of reactive oxygen species and glutathione. (2/25)
Annonaceous acetogenins are a new class of compounds that have been reported to have potent pesticidal, parasiticidal, anti-microbial, cell growth inhibitory activities. In this study, organic and aqueous extracts from the defatted seeds of Annona squamosa (custard apple) were tested on different human tumour cell lines for antitumoural activity. While organic and aqueous extracts induced apoptosis in MCF-7 and K-562 cells, they failed to do so in COLO-205 cells. Treatment of MCF-7 and K-562 cells with organic and aqueous extracts resulted in nuclear condensation, DNA fragmentation, induction of reactive oxygen species (ROS) generation and reduced intracellular glutathione levels. In addition downregulation of Bcl-2 and PS externalization by Annexin-V staining suggested induction of apoptosis in MCF-7 and K-562 cells by both the extracts through oxidative stress. On the contrary, COLO-205 cells showed only PS externalization but no change in ROS and glutathione levels. These observations suggest that the induction of apoptosis by A. squamosa extracts can be selective for certain types of cancerous cells. (+info)REM sleep behavior disorder in patients with guadeloupean parkinsonism, a tauopathy. (3/25)
STUDY OBJECTIVE: To describe sleep characteristics and rapid eye movement (REM) sleep behavior disorder in patients with Guadeloupean atypical parkinsonism (Gd-PSP), a tauopathy resembling progressive supranuclear palsy that mainly affects the midbrain. It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons. DESIGN: Sleep interview, motor and cognitive tests, and overnight videopolysomnography. PATIENTS: Thirty-six age-, sex-, disease-duration- and disability-matched patients with Gd-PSP (n = 9), progressive supranuclear palsy (a tauopathy, n = 9), Parkinson disease (a synucleinopathy, n = 9) and controls (n = 9). SETTINGS: Tertiary-care academic hospital. RESULTS: REM sleep behavior disorder was found in 78% patients with Gd-PSP (43% of patients reported having this disorder several years before the onset of parkinsonism), 44% of patients with idiopathic Parkinson disease, 33% of patients with progressive supranuclear palsy, and no controls. The percentage of muscle activity during REM sleep was greater in patients with Gd-PSP than in controls (limb muscle activity, 8.3%+/-8.7% vs 0.1%+/- 0.2%; chin muscle activity, 24.3%+/- 23.7% vs 0.7%+/-2.0%) but similar to that of other patient groups. The latency and percentage of REM sleep were similar in patients with Gd-PSP, patients with Parkinson disease, and controls, whereas patients with progressive supranuclear palsy had delayed and shortened REM sleep. CONCLUSION: Although Gd-PSP is a tauopathy, most patients experience REM sleep behavior disorder. This suggests that the location of neuronal loss or dysfunction in the midbrain, rather than the protein comprising the histologic lesions (synuclein versus tau aggregation), is responsible for suppressing muscle atonia during REM sleep. Subjects with idiopathic REM sleep behavior disorder should avoid eating sour sop. (+info)Synthesis of annonaceous acetogenins from muricatacin. (4/25)
Synthetic studies of annonaceous acetogenins starting from (-)-muricatacin (1a) or (+)-muricatacin are described, involving (-)-muricatacin (1a), mono-THF acetogenin, solamin (2), reticulatacin (3), (15R, 16R, 19S, 20S)-cis-solamin (4a) and (15S, 16S, 19R, 20R)-cis-solamin (4b), non-adjacent bis-THF acetogenin, 4-deoxygigantecin (5), and epoxide-bearing acetogenin, (15S, 16R, 19S, 20R)-diepomuricanin (6a). (+info)Anthelmintic acetogenin from Annona squamosa L. Seeds. (5/25)
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis. (+info)Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin. (6/25)
(+info)Halogenated terpenes and a C(15)-acetogenin from the marine red alga Laurencia saitoi. (7/25)
(+info)Genotoxic and cytotoxic effects produced by acetogenins obtained from Annona cherimolia Mill. (8/25)
In the present study we extracted three isomeric acetogenins (Ace) from the seeds of Annona cherimolia Mill. (Annonaceae) and determined their genotoxic and cytotoxic potential in mice. Our results showed a significant increase in the rate of micronucleated polychromatic erythrocytes induced by Ace with respect to the value for the control group; the effect was less pronounced than that observed with daunorubicin (Dau). To evaluate cytotoxicity, we determined the proportion of polychromatic erythrocytes with respect to the number of normochromatic erythrocytes, and we found an inhibitory effect induced by Ace that was quite similar to that observed with Dau. Besides, by means of the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide test, we also determined the cytotoxicity of Ace in both a normal fibroblast mouse cell line and in a line derived from human colon cancer. In this assay, the strongest decrease in viability corresponded to the malignant cell line. Our results established for the first time the genotoxic capacity of these compounds in vivo, and confirmed their cytotoxic potential in cultured cells. (+info)Fang, Xin-Ping; Rieser, Matthew J.; Gu, Zhe-Ming; Zhao, Geng-Xian; McLaughlin, Jerry L. (1993). "Annonaceous acetogenins: An ...
Tchen, T. T. (1965). "Reviewed Work: The Biosynthesis of Steroids, Terpenes & Acetogenins". American Scientist. 53 (4): 499A- ...
Acetogenins". American Scientist. Research Triangle Park, NC: Sigma Xi, The Scientific Research Society. 53 (4): 499A-500A. ...
... was the first known example in a class of compounds known as acetogenins. Acetogenins, which are found in plants of ... Zafra-Polo, M. C.; González, M. C.; Estornell, E.; Sahpaz, S.; Cortes, D. (1996). "Acetogenins from Annonaceae, Inhibitors of ...
... s are a group of chemical compounds classified as acetogenins. They are found in the extracts of Annona seeds. Some ...
It is a member of the class of compounds known as acetogenins. H. Naito; E. Kawahara; K. Maruta; M. Maeda; S. Sasaki (1995). " ... H.-W. Chih; H.-F. Chiu; K.-S. Tang; F.-R. Chang; Y.-C. Wu (2001). "Bullatacin, a potent antitumor annonaceous acetogenin, ... "The First Total Synthesis of (+)-Bullatacin, a Potent Antitumor Annonaceous Acetogenin, and (+)-(15,24)-bis-epi-Bullatacin". ... Two Highly Potent Bioactive Acetogenins from Annona bullata". Journal of Natural Products. 52 (3): 463-477. doi:10.1021/ ...
Champy P, Melot A, Guérineau Eng V, Gleye C, Fall D, Höglinger GU (2005). "Quantification of acetogenins in Annona muricata ... "Quantification of acetogenins inAnnona muricata linked to atypical parkinsonism in guadeloupe". Movement Disorders. 20 (12): ...
Other acetogenins have been isolated from the seeds, bark, and leaves. Natural Resources Conservation Service (NRCS). "PLANTS ... Bayer AG has patented the extraction process and molecular identity of the annonaceous acetogenin annonin, as well as its use ... 1990). "Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa". Journal of ... 2012). "Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds". Journal of ...
He published his findings on the Annonaceous acetogenins in peer reviewed journals. These acetogenins have been identified as ... McLaughlin, Jerry L. (2008). "Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products". Journal of ...
... is an acetogenin found in Uvaria chamae. Fall, D; Duval, RA; Gleye, C; Laurens, A; Hocquemiller, R (2004). " ... "Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae". Journal of Natural Products. 67 (6 ...
A large number of chemical compounds, including flavonoids, alkaloids, and acetogenins, have been extracted from the seeds and ... 2005-08-02). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Movement ...
Due to the presence of acetogenins, the leaves, twigs, and bark of pawpaw trees can be used to make an organic insecticide. The ... The disagreeable-smelling leaves, twigs, and bark of pawpaws contain natural insecticides known as acetogenins. Pawpaw leaves ... The seeds and bark contain the chemical asimitrin and other acetogenins, including asimin, asiminacin and asiminecin. ... new bioactive annonaceous acetogenins from the seeds of Asimina triloba possessing a bis-tetrahydrofuran ring". Journal of ...
Like other acetogenins, it is a mitochondrial complex I (NADH-dehydrogenase) inhibitor. As NADH-dehydrogenase is responsible ... It is a member of the class of compounds known as acetogenins. Although annonacin-containing fruit products are regularly ... a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related ... "Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS". Journal of Agricultural and Food ...
Like other members of the family Annonaceae, the seeds contain small amounts of neurotoxic acetogenins, such as annonacin, ... December 2005). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Mov. Disord. ...
"Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Movement Disorders. 20 (12): ...
Isolated Acetogenins and Biological Activities". International Journal of Molecular Sciences. 16 (7): 15625-15658. doi:10.3390/ ...
The leaves, twigs, and bark of the common pawpaw tree contain natural insecticides known as acetogenins. Larvae of the zebra ...
His major contribution was in the phytochemistry of Annonaceae plants, particularly in the chemistry of Acetogenins. Hisham ...
Overall, this provides a two-carbon homologation sequence that delivers the required acetogenin sequence. Borane hydrides such ...
Acetogenins from Annonaceae are even more potent inhibitors of complex I. They cross-link to the ND2 subunit, which suggests ... Bullatacin (an acetogenin found in Asimina triloba fruit) is the most potent known inhibitor of NADH dehydrogenase (ubiquinone ... "Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I". Biochimica et ... that ND2 is essential for quinone-binding.[36] Rolliniastatin-2, an acetogenin, is the first complex I inhibitor found that ...
"Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1 ...
Especially, mitochondrial complex I inhibitors (such as acetogenins, quinolines and rotenoids) are implicated in PSP-like brain ...
Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Movement Disorders, 2005-12-01 ...
Acetogenins from Annonaceae are even more potent inhibitors of complex I. They cross-link to the ND2 subunit, which suggests ... Interestingly, Rolliniastatin-2, an acetogenin, is the first complex I inhibitor found that does not share the same binding ... Degli Esposti M, Ghelli A, Ratta M, Cortes D, Estornell E (July 1994). "Natural substances (acetogenins) from the family ... an acetogenin found in Asimina triloba fruit) is the most potent known inhibitor of NADH dehydrogenase (ubiquinone) (IC50=1.2 ...
Other acetogenins have been discovered with anti-malarial and anti-tumor properties, and some even inhibit HIV replication in ... The first acetogenin discovered was uvaricin, which has anti-leukemic properties when used in living organisms. ... Several members of the family Annonaceae are also under investigation for uses of a group of chemicals called acetogenins. ...
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase ( ...
Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by ... Acetogenins have been investigated for their potential therapeutic use in treating cancer, but this potential is tempered with ... Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the Brazilian pawpaw (Annona ... Li, N.; Shi, Z.; Tang, Y.; Chen, J.; Li, X. (2008). "Recent Progress on the Total Synthesis of Acetogenins from Annonaceae" ( ...
... and one C15-acetogenin, neolaurallene (10), were isolated from a sample of marine red alga Laurencia saitoi collected off the ... Keywords: Laurencia saitoi; Diterpene; Triterpene; C15-acetogenin Laurencia saitoi; Diterpene; Triterpene; C15-acetogenin ... Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi. Nai-Yun Ji 1,* , Xiao-Ming Li 2. ... Ji N-Y, Li X-M, Wang B-G. Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi. Molecules. 2008 ...
Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung ... However acetogenins from natural sources could be good precursor molecules. Because the acetogenins from Annonaceae posses a ... Annonaceous acetogenins from the seeds of Annona sqamosa non-adjacent bis-tetrahydrofuranic acetogenins. Chem. Pharm. Bull. 42 ... Annonaceous acetogenins: precursors from the seed of Annona squamosa. Phytochem. Lett. 2. 72-76. Omar, S., Chee, C.L., Ahmad, F ...
Basically, there are more flavonoid type compounds in the leaf extracts and fewer if any acetogenins. Acetogenins are of great ... Basically, there are more flavonoid type compounds in the leaf extracts and fewer if any acetogenins. Acetogenins are of great ... Evaluation of decoction extracts of two types of soursop (Annona muricata) for annonaceous acetogenin properties [2014] ... The results indicated that present in the seeds were the confirmed acetogenins - annomutacin or cis-annomontacin (10.26 with MW ...
In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.: Annona ... The results showed that some fractions from woods were rich in acetogenins, alkaloids and terpenes, and other fractions from ... In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.. ... In this work, the antimalarial efficacy of different fractions of A. crassiflora, particularly acetogenin, alkaloids and ...
Role of acetogenins in combating drug-resistant cancer cells. Cancer cells can become immune to chemotherapy over time. They do ... Acetogenins against cancer: Phytochemicals with anti-cancer properties. What makes Graviola so great at killing cancer cells? ... Acetogenins slow down ATP production in cancer cells, therefore, hindering their ability to push away cancer-fighting chemicals ... Annonaceous acetogenins from Graviola can stop cancer cells from producing sufficient amounts of ATP, therefore, slowing their ...
biosynthesis of steroids terpenes and acetogenins by John H. Richards Download PDF EPUB FB2. The biosynthesis of steroids, ... The Biosynthesis of Steroids, Terpenes, and Acetogenins. John H. Richards and James B. Hendrickson. Benjamin, New York, xii + ... The biosynthesis of steroids, terpenes, and acetogenins (Frontiers in chemistry): J H & Hendrickson, J B Richards: Books - or: ... The biosynthesis of steroids terpenes and acetogenins pdf It will follow a logical pattern, to include an introductory ...
Fingerprint Dive into the research topics of Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins ... Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution. ... The merged fluorescence of dansyl-labeled solamin and MitoTracker Red suggests that Annonaceous acetogenins localize in the ... Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution. / ...
Isodesacetyluvaricin, an annonaceous acetogenin, specifically inhibits gene expression of cyclooxygenase-2. Tung Ying Wu, I. ... Isodesacetyluvaricin, an annonaceous acetogenin, specifically inhibits gene expression of cyclooxygenase-2. Journal of Natural ... Isodesacetyluvaricin, an annonaceous acetogenin, specifically inhibits gene expression of cyclooxygenase-2. In: Journal of ... Isodesacetyluvaricin, an annonaceous acetogenin, specifically inhibits gene expression of cyclooxygenase-2. / Wu, Tung Ying; ...
Experimental: Acetogenins Acetogenins twice (BID) per day for 12 months. Dietary Supplement: Acetogenins. ...
Tchen, T. T. (1965). "Reviewed Work: The Biosynthesis of Steroids, Terpenes & Acetogenins". American Scientist. 53 (4): 499A- ...
Thus far, more than 230 acetogenins from Asimina and other genera have been identified. 6 Acetogenins are known for their ... Of all the acetogenins, the adjacent-bis-THF-ring compounds are the most potent, showing cytotoxic activity against human lung ... In several studies performed in this manner it was found that specific acetogenins exhibited potent cytotoxicity. 7 , 9 , 11 , ... Biologically active acetogenins from stem bark of Asimina triloba. Phytochemistry . 1993;33:1065-1073.. 10. Zhao G, et al. ...
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But the acetogenins defeat this process. Additionally, the acetogenins in soursop block the cancer cells ability to use ATP, ... The acetogenins in soursop are especially promising, because they also counteract multi-drug resistance (MDR). This common ... This is because cancer cells have unique enzymes in their cell walls, and the acetogenins in soursop specifically disrupt those ... In soursop, compounds called acetogenins demonstrate very powerful activity against many forms of cancer cells, without harming ...
Anticancer effect of total annonaceous acetogenins on hepatocarcinoma Anticancer effect of total annonaceous acetogenins on ... Acetogenins , Chemistry , Pharmacology , Animals , Annona , Chemistry , Antineoplastic Agents, Phytogenic , Chemistry , ... p,,b,OBJECTIVE,/b,To confirm the anticancer effect of total annonaceous acetogenins (TAAs) abstracted from Annona squamosa Linn ...
Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa Eight new cytotoxic annonaceous acetogenins from ... Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), ... Acetogenins , Chemistry , Pharmacology , Toxicity , Annona , Chemistry , Antineoplastic Agents, Phytogenic , Chemistry , ...
Results document properties of avocado seed acetogenins as natural antilisterial food additives.Dec 31, 2016. ...
... acetogenins (especially bullatacin and bullatacinone); delta-9-tetrahydrocannabinol (dronabinol, MARINOL®); beta-lapachone; ...
Toxicities of acetogenin-based bioacaricides against two-spotted spider mite and selectivity to its phytoseiid predators ...
Docked images of; (A): Akt-Cannabidiol, (B): PI3K-Cannabidiol, (C): Akt-Acetogenin, (D): PI3K-Acetogenin, (E): Akt-Nimbin, (F ... cannabidiol and acetogenin to PI3K and Akt signaling molecules. Results showed that nimbin, cannabidiol and acetogenin ... Cannabidiol, nimbin and acetogenin an active constituent of Cannabis indica, Azadirachta indica and Annona muricata ... Annonaceous acetogenins is considered as to be the major bioactive constituent of it. A study conducted by Najmuddin et al ...
Fang, Xin-Ping; Rieser, Matthew J.; Gu, Zhe-Ming; Zhao, Geng-Xian; McLaughlin, Jerry L. (1993). "Annonaceous acetogenins: An ...
Chapter 11 An Introduction to Carbohydrates, Acetogenins and Steroids.. I. Introduction.. II. The Calvin Cycle. ...
Acetogenins from avocado pulp inhibited platelet aggregation with a potential preventive effect on thrombus formation.Oct 15, ...
Two new linear acetogenins from the fruits of Goniothalamus gracilipes.. Trieu QH, Mai HDT, Litaudon M, Phi Thi D, Tran TA, ...
AnnonaGraviolaReported that the Annonaceous acetogeninsAnnonaceous acetogeninAlkaloidsAntitumorTerpenesPhytochemicalsSoursopSeeds1997ExtractsStyryl lactones1999CytotoxicityTumorsInhibitSelective toxicity10,000 timesPotentSubstancesGoniothalamusAnnonacinMulti-drug resistant cancerMitochondrialMoleculesTumor cellsCancerous cellsCancerInsecticidalCharacterizationNaturalTwigsConstituentsResearchers foundExtractPurdueAntioxidantAvocadoRecent ProgressActivityFindings
- Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the Brazilian pawpaw (Annona muricata) remain under basic research for their possible biological properties. (wikipedia.org)
- In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart. (mysciencework.com)
- To confirm the anticancer effect of total annonaceous acetogenins (TAAs) abstracted from Annona squamosa Linn. (bvsalud.org)
- Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. (bvsalud.org)
- Two new annonaceous acetogenins named as squamostanin-A and squamostanin-B were isolated from 95% EtOH extract of the seeds of Annona squamosa. (encognitive.com)
- Amongst other botanical sources, Annona muricata L., Annonaceae, seeds and Piper nigrum L., Piperaceae, fruits are particularly enriched with acetogenins and piperine-related amides, respectively. (scielo.br)
- Squamocin, a new cytotoxic bis-tetrahydrofuran containing acetogenin from Annona squamosa. (nii.ac.jp)
- Polyketide Natural Products, Acetogenins from Graviola (Annona muricata L), its Biochemical, Cytotoxic Activity and Various Analyses Through Computational and Bio-Programming Methods. (google.com)
- However the Annonaceous acetogenins also appear in other species from this family such as Annona Montana . (tropilab.com)
- Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata. (vitanatural.net)
- New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. (vitanatural.net)
- The authors explain that this species is widely cultivated in South America, Spain, and Portugal, with Acetogenins documented in its seeds, stems, and roots yet it is unclear if Annona cherimolia contains AAGs 2 . (thermofisher.com)
- Identification of the environmental neurotoxins annonaceous acetogenins in an Annona cherimolia Mill. (thermofisher.com)
- Guanabana or soursop ( Annona muricata ) The plant has a strong antibiotic power due to its content in acetogenins, especially the leaves and seeds. (botanical-online.com)
- Annonaceous acetogenins from Graviola can stop cancer cells from producing sufficient amounts of ATP, therefore, slowing their growth rate. (sanusqliposomal.com)
- This species is known as soursop or as "graviola" in Brazil and it represents a source of acetogenins. (scielo.br)
- Researchers exploring the mechanisms that graviola uses claim that the acetogenins in the plant can distinguish cancerous cells from healthy cells because cancer cells have a consistently higher level of cellular activity. (howstuffworks.com)
- One of the eight published clinical studies demonstrated that one of the acetogenins in Graviola was selectively cytotoxic to colon adenocarcinoma cells. (wholeworldbotanicals.com)
- Most of the research on graviola focuses on a novel set of chemicals called Annonaceous acetogenins . (life-enthusiast.com)
- Four studies were published in 1998 which further specify the chemicals and acetogenins in graviola which are demonstrating the strongest anticancerous, antitumorous, and antiviral properties. (life-enthusiast.com)
- Studies have shown that the graviola tree leaf may destroy cancer cells due to its active natural phytochemical, annonaceous acetogenins (this compound plays a key role in preventing cancer cells from producing energy). (doctorshealthpress.com)
- however, the in vitro trials are still very promising.In a study published in the Journal of Natural Products in 1996, researchers at the Catholic University of South Korea found that the main graviola acetogenin, called annonacin, is 10,000 times stronger than the common chemotherapy drug, "Adriamycin. (doctorshealthpress.com)
- Recent scientific studies suggest that Acetogenins, the active constituents of Graviola, can support healthy cell growth and function. (wonderlabs.com)
- In the laboratory, the graviola substances called annonaceous acetogenins inhibited the growth or multi-drug resistant-cancer cells, as reported in the June 1997 issue of the "Journal of Medicinal Chemistry. (livestrong.com)
- Recently, we reported that the Annonaceous acetogenins can selectively inhibit the growth of cancerous cells and also inhibit the growth of adriamycin resistant tumor cells. (wholeworldbotanicals.com)
- The convergent synthesis of fluorescence-labeled solamin, an antitumor Annonaceous acetogenin, was accomplished by two asymmetric alkynylations of 2,5-diformyl tetrahydrofuran with an alkyne tagged with fluorescent groups and another alkyne with an α,β-unsaturated γ-lactone. (elsevier.com)
- Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. (uncg.edu)
- Circumvention of tumor multidrug resistance by a new annonaceous acetogenin: atemoyacin-B. (biomedsearch.com)
- acetogenins (Jiang and Yu 1997), alkaloids (Omar et al. (thefreelibrary.com)
- In vivo antimalarial efficacy of acetogenins, alkaloids and fl. (mysciencework.com)
- In this work, the antimalarial efficacy of different fractions of A. crassiflora, particularly acetogenin, alkaloids and flavonoid-rich fractions, was determined in vivo using Plasmodium berghei-infected mice model and toxicity was accessed by brine shrimp assay. (mysciencework.com)
- The results showed that some fractions from woods were rich in acetogenins, alkaloids and terpenes, and other fractions from leaves were rich in alkaloids and flavonoids. (mysciencework.com)
- Scientists attribute the family's wide range of pharmacological activities to acetogenins and isoquinolines, specifically aporphine alkaloids . (naturalnews.com)
- It has edible fruit and seeds which contain acetogenins and benzoquinazoline and other alkaloids. (nih.gov)
- Several of the Annonacae acetogenins show remarkable antitumor activity. (organic-chemistry.org)
- The antitumor, properties of these annonaceous acetogenins have been reported. (tropilab.com)
- Ji N-Y, Li X-M, Wang B-G. Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi . (mdpi.com)
- 2 edition of biosynthesis of steroids terpenes and acetogenins found in the catalog. (howtogetridofbadbreath.club)
- The biosynthesis of steroids, terpenes, and acetogenins Paperback - January 1, See all 2 formats and editions Hide other formats and editions PriceManufacturer: W.A. (howtogetridofbadbreath.club)
- The biosynthesis of steroids, terpenes, and acetogenins (Frontiers in chemistry) Hardcover - January 1, by John Richards (Author)Price: $ THE BIOSYNTHESIS OF STERIODS, TERPENES, AND ACETOGENINS [Richards, John H. (howtogetridofbadbreath.club)
- Book Reviews: The Biosynthesis of Steroids, Terpenes, and Acetogenins). (howtogetridofbadbreath.club)
- Book Reviews: The Biosynthesis of Steroids, Terpenes, and Acetogenins) Book Authors: Richards, John H. (howtogetridofbadbreath.club)
- The biosynthesis of steroids, terpenes, and acetogenins (Frontiers in chemistry): J H & Hendrickson, J B Richards: Books - or: Richards, J H & Hendrickson, J B. (howtogetridofbadbreath.club)
- In a search for phytochemicals with anti-inflammatory activity, the COX-2 inhibitory activity of 15 typical Annonaceous acetogenins was examined. (elsevier.com)
- No, they are phytochemicals called annonaceous acetogenins. (scribd.com)
- There is ongoing cancer-research on this plant concerning the specific phytochemicals ( Annonaceous acetogenins ) that are demonstrating the strongest anticancer and antiviral properties . (tropilab.com)
- Focus of the research was on a novel set of phytochemicals ( annonaceous acetogenins ). (tropilab.com)
- This is because cancer cells have unique enzymes in their cell walls, and the acetogenins in soursop specifically disrupt those enzymes. (foxnews.com)
- The acetogenins in soursop are especially promising, because they also counteract multi-drug resistance (MDR). (foxnews.com)
- Additionally, the acetogenins in soursop block the cancer cells' ability to use ATP, or adenosine triphosphate. (foxnews.com)
- The results indicated that present in the seeds were the confirmed acetogenins - annomutacin or cis-annomontacin (10.26 with MW about 625), and the cyclic peptide called annomuricatin (MW 11.05). (fao.org)
- 13 In addition, acetogenins asimilobin, cis- and trans-murisolinones, and cis- and trans-bullatacinones have been isolated from pawpaw seeds. (drugs.com)
- Among them, the adjacent bis-tetrahydrofuranic acetogenins (bis-THF ACG) with a threo/cis/threo/cis/erythro relative configuration, have been described as the most potent subgroup, the prototypical member of which, rolliniastatin-1 , was originally isolated from Rollinia membranacea seeds. (cognizantcommunication.com)
- Seeds contained 1.6 times higher levels of acetogenins than pulp (5048.1 ± 575.5 and 3107.0 ± 207.2 mg/kg fresh weight, respectively), and total content in pulp was 199 to 398 times higher than MIC values. (barfblog.com)
- 6. Oberlies NH, Chang CJ, McLaughlin JL (1997) Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. (vitanatural.net)
- The dry leaf and seed alcohol extracts were analyzed by LC-MS to determine the phyto-chemical and cytotoxic (anti-tumor) properties and to classify them into the group of active annonaceous acetogenins. (fao.org)
- 9 The acetogenins asimin, asiminacin, and asiminecin (all structural isomers) from pawpaw stem bark extracts were determined and also found to have highly cytotoxic properties. (drugs.com)
- Minimum inhibitory concentration (MIC) values of extracts and two isolated acetogenins varied between 7.8 and 15.6 mg/L, were effective at 37 and 4 °C, and showed a bactericidal effect probably caused by increased membrane permeability and lytic effects, evidenced by flow cytometry at 10 and 100× MIC. (barfblog.com)
- Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. (thefreelibrary.com)
- An investigation of the chemical constituents in a dichloromethnae extract of Goniothalamus undulatus root led to the isolation of three known styryl lactones (5-acetoxyisogoniothalamin oxide, O-acetylaltholactone and altholactone), and four known annonaceous acetogenins (annonacin, cis-annonacin, goniothalamicin and cis-goniothalamicin). (thefreelibrary.com)
- Irrespective of the presence of cytotoxic acetogenins and styryl-lactones in the genus Goniothalamus, only 22 species in the genus Goniothalamus, out of 160 species (13.7%) have so far been inves. (encognitive.com)
- Alali FQ, Liu XX, McLaughlin JL (1999) Annonaceous acetogenins: recent progress. (springer.com)
- In several studies performed in this manner it was found that specific acetogenins exhibited potent cytotoxicity. (drugs.com)
- Many of the acetogenins have a cytotoxicity with ED50 values as low as 10-9 ug/ml. (wholeworldbotanicals.com)
- As more acetogenins have been isolated and additional cytotoxicity assays have been conducted, we have noticed that, although most of acetogenins have high potencies among several solid human tumor cell lines, some of the derivatives within the different structural types and some positional isomers showed remarkable selectivities among certain cell lines, e.g., against prostate cancer (PC-3). (wholeworldbotanicals.com)
- Some of the Annonaceous acetogenins are not only effective in killing tumors that have proven resistant to anti- cancer agents, but also seem to have a special affinity for such resistant cells. (tropilab.com)
- It was discovered that the annonaceous acetogenins could also kill tumors previously resistant toward anti-cancer agents! (doctorshealthpress.com)
- The acetogenins recognize and selectively inhibit the cancer cells. (howstuffworks.com)
- Many of the acetogenins have demonstrated selective toxicity to tumor cells at very low dosages - as little as 1 part per million. (life-enthusiast.com)
- In this study the Annonaceous acetogenins were shown to possess 10,000 times the potency of adriamycin. (wholeworldbotanicals.com)
- Annonaceous acetogenins (ACG) are a large family of natural products that have been described as the most potent in vitro inhibitors of the mitochondrial respiratory chain Complex I. During the last two decades a large number of related structures have been discovered, increasing the number of members of this family. (cognizantcommunication.com)
- Most potent acetogenins were Persenone C (5) and A (6), and AcO-avocadenyne (1), the latter exclusively present in seed. (barfblog.com)
- Annonaceous acetogenins are waxy substances consisting of C32 or C34 long chain fatty acids which have been combined with a 2-propanol unit at C-2 to form a lactone. (wholeworldbotanicals.com)
- 20 Acetogenins, substances which have excellent potential for antineoplasic and cytotoxic activities, were isolated from different organs of this species. (sld.cu)
- The plant has substances derived from fatty acids called annonaceous acetogenins, which are being extensively studied for their effects, according to 2009 information from Drugs.com. (livestrong.com)
- Two new linear acetogenins from the fruits of Goniothalamus gracilipes. (pubfacts.com)
- 2,4-Cis and Trans)-Gigantecinone and 4-Deoxygigantecin, Bioactive Nonadjacent Bis-Tetrahydrofuran Annonaceous Acetogenins, from Goniothalamus Giganteus, J. Nat. (patentgenius.com)
- 7 , 8 In addition, acetogenins cis- and trans-annonacin-a-one, cis- and trans-gigantetrocinone, trans-isoannonacin, and squamolone have been determined. (drugs.com)
- Purdue researchers reported that annonaceous acetogenins preferentially killed multi-drug resistant cancer cells because it blocked production of adenosine triphosphate (ATP). (scribd.com)
- 1995). Acetogenins act as pesticides on several arthopodes what is based on a specific mechanism that blocks energy generation in the mitochondrial complex I. Another species, Piper nigrum L., Piperaceae, which is commonly used as black pepper, contains a series of amides also possessing insecticidal potential such as piperine, pipercide, guineensine, pellitorine, pipgulzarine and pipzorine (Park et al. (scielo.br)
- Scientific literature has reported several phytoconstituents such as Acetogenins, whose biological activity is focused on the inhibition of mitochondrial complex I (NADH: ubiquinone oxidoreductase) . (pubmedcentralcanada.ca)
- The aim of present study was to analyze the interaction of plant derived natural moieties such as nimbin, cannabidiol and acetogenin to PI3K and Akt signaling molecules. (jbiomed.com)
- Results showed that nimbin, cannabidiol and acetogenin significantly binds to both signaling molecules. (jbiomed.com)
- We determined the antilisterial properties of an enriched acetogenin extract (EAE) from avocado seed , compared it to two commercial antimicrobials (one enriched in avocado acetogenins), and tested purified molecules. (barfblog.com)
- Mode of action studies in three separate laboratories have recently determined that these acetogenins are superb inhibitors of enzyme processes that are only found in the membranes of cancerous tumor cells. (life-enthusiast.com)
- These studies have discovered that the active acetogenins are effective in the treatment of cancerous cells in the pancreas, prostate, lung, colon, and breast. (doctorshealthpress.com)
- Acetogenins have been investigated for their potential therapeutic use in treating cancer, but this potential is tempered with concerns about neurotoxicity. (wikipedia.org)
- Acetogenins are of great interest for their cytotoxic activities (anti-cancer) and are also toxic to insects. (fao.org)
- What's more, acetogenins can combat even the most stubborn cancer cells that resist traditional cancer drugs. (sanusqliposomal.com)
- Assay for the growth inhibitory activity against human cancer cell lines revealed that the probe with the fluorescent groups at the end of the hydrocarbon chain may have the same mode of action as natural acetogenins. (elsevier.com)
- The following sections of the article will briefly discuss the role of these 3 natural moieties named as nimbin, cannabidiol and acetogenin in overcoming various complications of breast cancer. (jbiomed.com)
- Researchers from Ohio State University found that two of avocados' acetogenins - dihydroxyheptadecenyl acetate and dihydroxyheptadecynyl acetate - inhibited the growth of cancer cells. (healthimpactnews.com)
- The researchers found that these two acetogenins blocked the phosphorylation process of oral cancer cells. (healthimpactnews.com)
- Purdue University, in West Lafayette, Indiana, has conducted a great deal of the research on the acetogenins, much of which, has been funded by The National Cancer Institute and/or the National Institute of Health (NIH). (life-enthusiast.com)
- Basically, the cancer cells will push the anti-cancer agents out of the cell before they can be killed.The Purdue researchers found that the acetogenins eliminated multi-drug resistant (MDR) cancer cells by blocking the main source of cellular energy, ATP (adenosine triphosphate). (doctorshealthpress.com)
- Therefore, the acetogenins limit the energy toward the cancer cells, and the pump cannot run. (doctorshealthpress.com)
- The study also found that 13 of 14 acetogenins analyzed in MDR breast cells had a greater effect than three common anti-cancer drugs, including Adriamycin, "Vinblastine," and "Vincristine. (doctorshealthpress.com)
- Purdue University and/or its staff have filed at least 9 U.S. and/or international patents on their work around the antitumorous and insecticidal properties and uses of these acetogenins. (scribd.com)
- 2012) " Comprehensive characterization of Annonaceous acetogenins within a complex extract by HPLC-ESI-LTQ-Orbitrap® using post-column lithium infusion . (thermofisher.com)
- The acetogenins (these are natural chemicals) are found to be responsible for that important activity. (tropilab.com)
- Results document properties of avocado seed acetogenins as natural antilisterial food additives. (barfblog.com)
- Natures Sunshine uses an extract of the twigs of the North American paw paw tree, which contain the most concentrated amount of acetogenins. (healthy-sunshine.com)
- More recent scientific studies suggest that Acetogenins, the active constituents of. (lifestylemarkets.com)
- The Monterey researchers found two addition acetogenins in their research. (healthimpactnews.com)
- A clinical study with over 100 participants showed that the paw paw extract, containing a mixture of acetogenins, supports the bodys normal cells during times of cellular stress. (healthy-sunshine.com)
- Much of Purdue University's research on annonaceous acetogenins was funded by the NCI and/or the NIH. (scribd.com)
- The acetogenins in avocados have been found to provide more than just antioxidant benefits. (healthimpactnews.com)
- So far, five acetogenins have been found in avocado. (healthimpactnews.com)
- Acetogenin composition in pulp and seed of Hass avocado was quantified. (barfblog.com)
- Mikolajczak, McLaughlin, and Rupprecht (1989) discovered effective pesticidal activity in Annonaceous Acetogenins. (wholeworldbotanicals.com)