Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.Annona: A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain acetogenins and benzoquinazoline and other alkaloids.Annonaceae: The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Uvaria: A plant genus of the family ANNONACEAE. Members contain uvarigrin, uvarigrandin, chamuvaritin and other acetogenins and benzylisoquinoline alkaloids.Benzethonium: Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.Lactones: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.Laurencia: A genus of RED ALGAE in the family Rhodomelaceae. Some species are a rich source of chlorine-and bromine-containing metabolites which show significant antibacterial activity.Electron Transport Complex I: A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.
(1/25) Inhibitory activities of three annonaceous acetogenins on NADH oxidase of chicken liver mitochondria.

Annonaceous acetogenins (ACG) are natural products found in the plant family Annonaceae and which strongly inhibited mitochondrial complex I. The inhibition of NADH oxidase of chicken liver mitochondria by three different structural ACG was studied here, and ACG was shown to have potent inhibitory activities similar to rotenone for NADH oxidase. The IC(50) values indicated that bis-adjacent tetrahydrofuran (THF) type squamocin C was more potent than non-adjacent bis-THF type squamostatin B, and the latter was more potent than non-THF type compound 1 in the assay. The roles of structural factors of ACG such as the terminal gamma-lactone, the features of other ring moieties and hydroxyl groups, as well as the alkyl chain were simply discussed in this study.  (+info)

(2/25) Differential cytotoxic effects of Annona squamosa seed extracts on human tumour cell lines: role of reactive oxygen species and glutathione.

Annonaceous acetogenins are a new class of compounds that have been reported to have potent pesticidal, parasiticidal, anti-microbial, cell growth inhibitory activities. In this study, organic and aqueous extracts from the defatted seeds of Annona squamosa (custard apple) were tested on different human tumour cell lines for antitumoural activity. While organic and aqueous extracts induced apoptosis in MCF-7 and K-562 cells, they failed to do so in COLO-205 cells. Treatment of MCF-7 and K-562 cells with organic and aqueous extracts resulted in nuclear condensation, DNA fragmentation, induction of reactive oxygen species (ROS) generation and reduced intracellular glutathione levels. In addition downregulation of Bcl-2 and PS externalization by Annexin-V staining suggested induction of apoptosis in MCF-7 and K-562 cells by both the extracts through oxidative stress. On the contrary, COLO-205 cells showed only PS externalization but no change in ROS and glutathione levels. These observations suggest that the induction of apoptosis by A. squamosa extracts can be selective for certain types of cancerous cells.  (+info)

(3/25) REM sleep behavior disorder in patients with guadeloupean parkinsonism, a tauopathy.

STUDY OBJECTIVE: To describe sleep characteristics and rapid eye movement (REM) sleep behavior disorder in patients with Guadeloupean atypical parkinsonism (Gd-PSP), a tauopathy resembling progressive supranuclear palsy that mainly affects the midbrain. It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons. DESIGN: Sleep interview, motor and cognitive tests, and overnight videopolysomnography. PATIENTS: Thirty-six age-, sex-, disease-duration- and disability-matched patients with Gd-PSP (n = 9), progressive supranuclear palsy (a tauopathy, n = 9), Parkinson disease (a synucleinopathy, n = 9) and controls (n = 9). SETTINGS: Tertiary-care academic hospital. RESULTS: REM sleep behavior disorder was found in 78% patients with Gd-PSP (43% of patients reported having this disorder several years before the onset of parkinsonism), 44% of patients with idiopathic Parkinson disease, 33% of patients with progressive supranuclear palsy, and no controls. The percentage of muscle activity during REM sleep was greater in patients with Gd-PSP than in controls (limb muscle activity, 8.3%+/-8.7% vs 0.1%+/- 0.2%; chin muscle activity, 24.3%+/- 23.7% vs 0.7%+/-2.0%) but similar to that of other patient groups. The latency and percentage of REM sleep were similar in patients with Gd-PSP, patients with Parkinson disease, and controls, whereas patients with progressive supranuclear palsy had delayed and shortened REM sleep. CONCLUSION: Although Gd-PSP is a tauopathy, most patients experience REM sleep behavior disorder. This suggests that the location of neuronal loss or dysfunction in the midbrain, rather than the protein comprising the histologic lesions (synuclein versus tau aggregation), is responsible for suppressing muscle atonia during REM sleep. Subjects with idiopathic REM sleep behavior disorder should avoid eating sour sop.  (+info)

(4/25) Synthesis of annonaceous acetogenins from muricatacin.

Synthetic studies of annonaceous acetogenins starting from (-)-muricatacin (1a) or (+)-muricatacin are described, involving (-)-muricatacin (1a), mono-THF acetogenin, solamin (2), reticulatacin (3), (15R, 16R, 19S, 20S)-cis-solamin (4a) and (15S, 16S, 19R, 20R)-cis-solamin (4b), non-adjacent bis-THF acetogenin, 4-deoxygigantecin (5), and epoxide-bearing acetogenin, (15S, 16R, 19S, 20R)-diepomuricanin (6a).  (+info)

(5/25) Anthelmintic acetogenin from Annona squamosa L. Seeds.

Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.  (+info)

(6/25) Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin.

 (+info)

(7/25) Halogenated terpenes and a C(15)-acetogenin from the marine red alga Laurencia saitoi.

 (+info)

(8/25) Genotoxic and cytotoxic effects produced by acetogenins obtained from Annona cherimolia Mill.

In the present study we extracted three isomeric acetogenins (Ace) from the seeds of Annona cherimolia Mill. (Annonaceae) and determined their genotoxic and cytotoxic potential in mice. Our results showed a significant increase in the rate of micronucleated polychromatic erythrocytes induced by Ace with respect to the value for the control group; the effect was less pronounced than that observed with daunorubicin (Dau). To evaluate cytotoxicity, we determined the proportion of polychromatic erythrocytes with respect to the number of normochromatic erythrocytes, and we found an inhibitory effect induced by Ace that was quite similar to that observed with Dau. Besides, by means of the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide test, we also determined the cytotoxicity of Ace in both a normal fibroblast mouse cell line and in a line derived from human colon cancer. In this assay, the strongest decrease in viability corresponded to the malignant cell line. Our results established for the first time the genotoxic capacity of these compounds in vivo, and confirmed their cytotoxic potential in cultured cells.  (+info)

*  Acetogenin
Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by ... Acetogenins have been investigated for their potential therapeutic use in treating cancer, but this potential is tempered with ... Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the Brazilian pawpaw (Annona ... Li, N.; Shi, Z.; Tang, Y.; Chen, J.; Li, X. (2008). "Recent Progress on the Total Synthesis of Acetogenins from Annonaceae" ( ...
*  Phytochemical Analysis
Fang, Xin-Ping; Rieser, Matthew J.; Gu, Zhe-Ming; Zhao, Geng-Xian; McLaughlin, Jerry L. (1993). "Annonaceous acetogenins: An ...
*  Medicinal plants
Tchen, T. T. (1965). "Reviewed Work: The Biosynthesis of Steroids, Terpenes & Acetogenins". American Scientist. Research ...
*  Phytochemistry
Acetogenins". American Scientist. Research Triangle Park, NC: Sigma Xi, The Scientific Research Society. 53 (4): 499A-500A. ...
*  Uvaricin
... was the first known example in a class of compounds known as acetogenins. Acetogenins, which are found in plants of ... Zafra-Polo, M. C.; González, M. C.; Estornell, E.; Sahpaz, S.; Cortes, D. (1996). "Acetogenins from Annonaceae, Inhibitors of ...
*  Annonin
... s are a group of chemical compounds classified as acetogenins. They are found in the extracts of Annona seeds. Some ...
*  Bullatacin
It is a member of the class of compounds known as acetogenins. H. Naito; E. Kawahara; K. Maruta; M. Maeda; S. Sasaki (1995). " ... H.-W. Chih; H.-F. Chiu; K.-S. Tang; F.-R. Chang; Y.-C. Wu (2001). "Bullatacin, a potent antitumor annonaceous acetogenin, ... "The First Total Synthesis of (+)-Bullatacin, a Potent Antitumor Annonaceous Acetogenin, and (+)-(15,24)-bis-epi-Bullatacin". ... Two Highly Potent Bioactive Acetogenins from Annona bullata". Journal of Natural Products. 52 (3): 463-477. doi:10.1021/ ...
*  Soursop
Champy P, Melot A, Guérineau Eng V, Gleye C, Fall D, Höglinger GU (2005). "Quantification of acetogenins in Annona muricata ... "Quantification of acetogenins inAnnona muricata linked to atypical parkinsonism in guadeloupe". Movement Disorders. 20 (12): ...
*  Annona squamosa
Other acetogenins have been isolated from the seeds, bark, and leaves. Natural Resources Conservation Service (NRCS). "PLANTS ... Bayer AG has patented the extraction process and molecular identity of the annonaceous acetogenin annonin, as well as its use ... 1990). "Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa". Journal of ... 2012). "Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds". Journal of ...
*  Jerry L. McLaughlin
He published his findings on the Annonaceous acetogenins in peer reviewed journals. These acetogenins have been identified as ... McLaughlin, Jerry L. (2008). "Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products". Journal of ...
*  Chamuvarinin
... is an acetogenin found in Uvaria chamae. Fall, D; Duval, RA; Gleye, C; Laurens, A; Hocquemiller, R (2004). " ... "Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae". Journal of Natural Products. 67 (6 ...
*  Annonaceae
A large number of chemical compounds, including flavonoids, alkaloids, and acetogenins, have been extracted from the seeds and ... 2005-08-02). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Movement ...
*  Asimina triloba
Due to the presence of acetogenins, the leaves, twigs, and bark of pawpaw trees can be used to make an organic insecticide. The ... The disagreeable-smelling leaves, twigs, and bark of pawpaws contain natural insecticides known as acetogenins. Pawpaw leaves ... The seeds and bark contain the chemical asimitrin and other acetogenins, including asimin, asiminacin and asiminecin. ... new bioactive annonaceous acetogenins from the seeds of Asimina triloba possessing a bis-tetrahydrofuran ring". Journal of ...
*  Annonacin
Like other acetogenins, it is a mitochondrial complex I (NADH-dehydrogenase) inhibitor. As NADH-dehydrogenase is responsible ... It is a member of the class of compounds known as acetogenins. Although annonacin-containing fruit products are regularly ... a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related ... "Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS". Journal of Agricultural and Food ...
*  Cherimoya
Like other members of the family Annonaceae, the seeds contain small amounts of neurotoxic acetogenins, such as annonacin, ... December 2005). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Mov. Disord. ...
*  Annonamine
Isolated Acetogenins and Biological Activities". International Journal of Molecular Sciences. 16 (7): 15625-15658. doi:10.3390/ ...
*  Asimina
The leaves, twigs, and bark of the common pawpaw tree contain natural insecticides known as acetogenins. Larvae of the zebra ...
*  Poonthran
His major contribution was in the phytochemistry of Annonaceae plants, particularly in the chemistry of Acetogenins. Hisham ...
*  Organoboron chemistry
Overall, this provides a two-carbon homologation sequence that delivers the required acetogenin sequence. Borane hydrides such ...
*  Plasminogen activator inhibitor-1
"Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1 ...
*  NADH dehydrogenase (ubiquinone)
Acetogenins from Annonaceae are even more potent inhibitors of complex I. They cross-link to the ND2 subunit, which suggests ... Interestingly, Rolliniastatin-2, an acetogenin, is the first complex I inhibitor found that does not share the same binding ... Degli Esposti M, Ghelli A, Ratta M, Cortes D, Estornell E (July 1994). "Natural substances (acetogenins) from the family ... an acetogenin found in Asimina triloba fruit) is the most potent known inhibitor of NADH dehydrogenase (ubiquinone) (IC50=1.2 ...
*  Magnoliids
Other acetogenins have been discovered with anti-malarial and anti-tumor properties, and some even inhibit HIV replication in ... The first acetogenin discovered was uvaricin, which has anti-leukemic properties when used in living organisms. ... Several members of the family Annonaceae are also under investigation for uses of a group of chemicals called acetogenins. ...
*  Annona
The compound annonacin and dozens of other acetogenins contained in the seeds and fruit of some members of Annonaceae such as ... Several annonacaeous species have been found to contain acetogenins, a class of natural compounds with a wide variety of ... Esposti, M Degli; A Ghelli; M Ratta; D Cortes; E Estornell (1994-07-01). "Natural substances (acetogenins) from the family ...
*  Haloalkane
... acetogenins, and phenols). Halogenated alkanes in land plants are more rare, but do occur, as for example the fluoroacetate ...
*  Lauraceae
... acetogenins), furanosesquiterpenes, and germacranolidous, heliangolidous, eudesmanolidous and guaianolidous sesquiterpene ...
Nicholas  Oberlies , NC DOCKS (North Carolina Digital Online Collection of Knowledge and Scholarship)  Nicholas Oberlies , NC DOCKS (North Carolina Digital Online Collection of Knowledge and Scholarship)
Recent advances in Annonaceous acetogenins.. 1996. 12324. Annonaceous acetogenins are waxy substances consisting of C32 or C34 ... termed Annonaceous acetogenins. Even with over 400 acetogenins iden.... ... The Annonaceous Acetogenin Bullatacin Is Cytotoxic against Multidrug Resistant Human Mammary Adenocarcinoma Cells. 1997. 29. ... Tumor Cell Growth Inhibition by Several Annonaceous Acetogenins in an in Vitro Disk Diffusion Assay. 1995. 31. The cell ...
more infohttp://libres.uncg.edu/ir/clist.aspx?id=2969
Graviola Side Effects | HowStuffWorks  Graviola Side Effects | HowStuffWorks
The acetogenins recognize and selectively inhibit the cancer cells. Pregnant women are advised to avoid graviola because the ... Researchers exploring the mechanisms that graviola uses claim that the acetogenins in the plant can distinguish cancerous cells ...
more infohttps://health.howstuffworks.com/wellness/natural-medicine/herbal-remedies/graviola2.htm
Anona mäkkoostnatá - Wikipédia  Anona mäkkoostnatá - Wikipédia
Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Movement Disorders, 2005-12-01 ...
more infohttps://sk.wikipedia.org/wiki/Anona_m%C3%A4kkoostnat%C3%A1
Annonaceae - definition of Annonaceae by The Free Dictionary  Annonaceae - definition of Annonaceae by The Free Dictionary
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase ( ...
more infohttp://www.thefreedictionary.com/Annonaceae
cherimolin-1
     Summary Report | CureHunter  cherimolin-1 Summary Report | CureHunter
... an acetogenin from seeds of Annona cherimolia; inhibits NADH:ubiquinone oxidoreductase (complex I); structure in first source ... an acetogenin from seeds of Annona cherimolia; inhibits NADH:ubiquinone oxidoreductase (complex I); structure in first source ...
more infohttp://www.curehunter.com/public/keywordSummaryC109215-cherimolin-1.do
The Annona muricata leaf ethanol extract affects mobility and reproduction in mutant strain NB327 Caenorhabditis elegans  The Annona muricata leaf ethanol extract affects mobility and reproduction in mutant strain NB327 Caenorhabditis elegans
Also, these Acetogenins have cytotoxic properties against different tumor cell lines such as lung, prostate, liver, and colon [ ... It has been found that this effect could be produced by the Acetogenins, specially the Annonacin [47], [48]. Additionally, it ... The Acetogenins mechanism is based on the inhibition of mitochondrial complex I (NADH: ubiquinone oxidoreductase), which is ... 4. Yang G.S., C, Mukkavilli R., Vangala S., Reid M.D., Aneja R. Synergistic interactions among flavonoids and acetogenins in ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC5614673/
Graviola Cancer Cure The Mountain | caphab.com  Graviola Cancer Cure The Mountain | caphab.com
108 Mountain Graviola acetogenins. The acetogenins annonacin significant anticancer chemical found in all the trees, but the ... The more than one hundred acetogenins useful, it would be surprising that this plant is able to cure many fatal diseases other ... Montana acetogenins are effective given the tumor and eliminates damaged cells before they reach other organs. ... Muritica rose to fame as an alternative cures for cancer contains 82 acetogenins. As compared muritica Montana more of these ...
more infohttp://caphab.com/2017/03/graviola-cancer-cure-the-mountain/
laurendecumenyne B
     Summary Report | CureHunter  laurendecumenyne B Summary Report | CureHunter
... acetogenin from the marine red alga Laurencia decumbens; structure in first source ... halogenated nonterpenoid C(15)-acetogenin from the marine red alga Laurencia decumbens; structure in first source ...
more infohttp://www.curehunter.com/public/keywordSummaryC524239-laurendecumenyne-B.do
Sirsak/Soursop (Annona muricata L.) | CCRC  Sirsak/Soursop (Annona muricata L.) | CCRC
Soursop leaves contain acetogenin compound, essential oil, reticuline, loreximine, coclaurine, annomurine,higenamine. Soursop ... Mclaughlin., 2008, Paw-paw and Cancer Annonaceous Acetogenin from Discovery to Comercial Products, Department of Medicinal ...
more infohttp://ccrc.farmasi.ugm.ac.id/en/?page_id=2285
perihalbarah: Durian Belanda  perihalbarah: Durian Belanda
The active ingredient is thought to be a type of plant compound (phytochemical) called annonaceous acetogenins.People in ... and as a sedative.The Graviola herb has shown promising results and the active ingredients are called Annonaceous acetogenins. ...
more infohttp://perihalbarah.blogspot.com/2011/12/durian-belanda.html
Acetogenin - Wikipedia  Acetogenin - Wikipedia
Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by ... Acetogenins have been investigated for their potential therapeutic use in treating cancer, but this potential is tempered with ... Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the Brazilian pawpaw (Annona ... Li, N.; Shi, Z.; Tang, Y.; Chen, J.; Li, X. (2008). "Recent Progress on the Total Synthesis of Acetogenins from Annonaceae" ( ...
more infohttps://en.wikipedia.org/wiki/Acetogenin
Molecules | Free Full-Text | Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi  Molecules | Free Full-Text | Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi
... and one C15-acetogenin, neolaurallene (10), were isolated from a sample of marine red alga Laurencia saitoi collected off the ... Keywords: Laurencia saitoi; Diterpene; Triterpene; C15-acetogenin Laurencia saitoi; Diterpene; Triterpene; C15-acetogenin ... Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi. Nai-Yun Ji 1,* , Xiao-Ming Li 2. ... Ji N-Y, Li X-M, Wang B-G. Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi. Molecules. 2008 ...
more infohttps://www.mdpi.com/1420-3049/13/11/2894
Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung...  Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung...
Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung ... However acetogenins from natural sources could be good precursor molecules. Because the acetogenins from Annonaceae posses a ... Annonaceous acetogenins from the seeds of Annona sqamosa non-adjacent bis-tetrahydrofuranic acetogenins. Chem. Pharm. Bull. 42 ... Annonaceous acetogenins: precursors from the seed of Annona squamosa. Phytochem. Lett. 2. 72-76. Omar, S., Chee, C.L., Ahmad, F ...
more infohttps://www.thefreelibrary.com/Cytotoxic+activity+of+acetogenins+and+styryl+lactones+isolated+from+...-a0257677795
In vivo antimalarial efficacy of acetogenins, alkaloids and fl...  In vivo antimalarial efficacy of acetogenins, alkaloids and fl...
In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.: Annona ... The results showed that some fractions from woods were rich in acetogenins, alkaloids and terpenes, and other fractions from ... In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.. ... In this work, the antimalarial efficacy of different fractions of A. crassiflora, particularly acetogenin, alkaloids and ...
more infohttps://www.mysciencework.com/publication/show/vivo-antimalarial-efficacy-acetogenins-alkaloids-flavonoids-enriched-fractions-from-annona-crassiflora-mart-52702b0f
Evaluation of decoction extracts of two types of soursop (Annona muricata) for annonaceous acetogenin properties  Evaluation of decoction extracts of two types of soursop (Annona muricata) for annonaceous acetogenin properties
Basically, there are more flavonoid type compounds in the leaf extracts and fewer if any acetogenins. Acetogenins are of great ... Basically, there are more flavonoid type compounds in the leaf extracts and fewer if any acetogenins. Acetogenins are of great ... Evaluation of decoction extracts of two types of soursop (Annona muricata) for annonaceous acetogenin properties [2014] ... The results indicated that present in the seeds were the confirmed acetogenins - annomutacin or cis-annomontacin (10.26 with MW ...
more infohttp://agris.fao.org/agris-search/search.do?request_locale=es&recordID=US201500074843&sourceQuery=&query=&sortField=&sortOrder=&agrovocString=&advQuery=¢erString=&enableField=&aggregatorField=
Targeting breast cancer cell signaling molecules PI3K and Akt by phytochemicals Cannabidiol, Nimbin and Acetogenin: An in...  Targeting breast cancer cell signaling molecules PI3K and Akt by phytochemicals Cannabidiol, Nimbin and Acetogenin: An in...
Docked images of; (A): Akt-Cannabidiol, (B): PI3K-Cannabidiol, (C): Akt-Acetogenin, (D): PI3K-Acetogenin, (E): Akt-Nimbin, (F ... cannabidiol and acetogenin to PI3K and Akt signaling molecules. Results showed that nimbin, cannabidiol and acetogenin ... Cannabidiol, nimbin and acetogenin an active constituent of Cannabis indica, Azadirachta indica and Annona muricata ... Annonaceous acetogenins is considered as to be the major bioactive constituent of it. A study conducted by Najmuddin et al ...
more infohttp://jbiomed.com/v03p0060.htm
Phytochemical Analysis - Wikipedia  Phytochemical Analysis - Wikipedia
Fang, Xin-Ping; Rieser, Matthew J.; Gu, Zhe-Ming; Zhao, Geng-Xian; McLaughlin, Jerry L. (1993). "Annonaceous acetogenins: An ...
more infohttps://en.wikipedia.org/wiki/Phytochemical_Analysis
Listeria Infections | GreenMedInfo | Disease | Natural Medicine  Listeria Infections | GreenMedInfo | Disease | Natural Medicine
Results document properties of avocado seed acetogenins as natural antilisterial food additives.Dec 31, 2016. ...
more infohttp://www.greenmedinfo.com/disease/listeria-infections
Pawpaw Uses, Benefits & Dosage - Drugs.com Herbal Database  Pawpaw Uses, Benefits & Dosage - Drugs.com Herbal Database
Thus far, more than 230 acetogenins from Asimina and other genera have been identified. 6 Acetogenins are known for their ... Of all the acetogenins, the adjacent-bis-THF-ring compounds are the most potent, showing cytotoxic activity against human lung ... In several studies performed in this manner it was found that specific acetogenins exhibited potent cytotoxicity. 7 , 9 , 11 , ... Biologically active acetogenins from stem bark of Asimina triloba. Phytochemistry . 1993;33:1065-1073.. 10. Zhao G, et al. ...
more infohttps://www.drugs.com/npp/pawpaw.html
  • Among them, the adjacent bis-tetrahydrofuranic acetogenins (bis-THF ACG) with a threo/cis/threo/cis/erythro relative configuration, have been described as the most potent subgroup, the prototypical member of which, rolliniastatin-1 , was originally isolated from Rollinia membranacea seeds. (cognizantcommunication.com)
  • 1995). Acetogenins act as pesticides on several arthopodes what is based on a specific mechanism that blocks energy generation in the mitochondrial complex I. Another species, Piper nigrum L., Piperaceae, which is commonly used as black pepper, contains a series of amides also possessing insecticidal potential such as piperine, pipercide, guineensine, pellitorine, pipgulzarine and pipzorine (Park et al. (scielo.br)
  • The aim of present study was to analyze the interaction of plant derived natural moieties such as nimbin, cannabidiol and acetogenin to PI3K and Akt signaling molecules. (jbiomed.com)
  • Results showed that nimbin, cannabidiol and acetogenin significantly binds to both signaling molecules. (jbiomed.com)