Acetanilides: Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Confidentiality: The privacy of information and its protection against unauthorized disclosure.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)AmidohydrolasesCytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Licensure: The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Aniline CompoundsUrtica dioica: A plant species of the genus Urtica, family URTICACEAE. Roots have been used to treat PROSTATIC HYPERPLASIA. Leaves are edible after the stinging quality is eliminated by brief heating.Dictionaries, ChemicalEmollients: Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Unconscious (Psychology): Those forces and content of the mind which are not ordinarily available to conscious awareness or to immediate recall.Emergency Responders: Personnel trained to provide the initial services, care, and support in EMERGENCIES or DISASTERS.Contact Lenses: Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)Clothing: Fabric or other material used to cover the body.Earthquakes: Sudden slips on a fault, and the resulting ground shaking and radiated seismic energy caused by the slips, or by volcanic or magmatic activity, or other sudden stress changes in the earth. Faults are fractures along which the blocks of EARTH crust on either side have moved relative to one another parallel to the fracture.Disinfectants: Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)Disasters: Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community.
(1/292) Propachlor removal by Pseudomonas strain GCH1 in an immobilized-cell system.

A bacterial strain capable of growing on propachlor (2-chloro-N-isopropylacetanilide) was isolated from soil by using enrichment and isolation techniques. The strain isolated, designated GCH1, was classified as a member of the genus Pseudomonas. Washed-cell suspensions of strain GCH1 accumulated N-isopropylacetanilide, acetanilide, acetamide, and catechol. Pseudomonas strain GCH1 grew on propachlor with a generation time of 4.2 h and a rate of substrate utilization of 1.75 +/- 0.15 micromol h(-1). Gene expression did not require induction but was subject to catabolite expression. Acetanilide was a growth substrate with a yield of 0.56 +/- 0.02 mg of protein micromol(-1). GCH1 strain cells were immobilized by adsorption onto a ceramic support and were used as biocatalysts in an immobilized cell system. Propachlor elimination reached 98%, with a retention time of 3 h and an initial organic load of 0.5 mM propachlor. The viability of immobilized cells increased 34-fold after 120 days of bioreactor operation.  (+info)

(2/292) Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS, and LC-ESI-MS-MS.

A case of self poisoning with metobromuron, a urea derivative used as a herbicide, is reported. Severe methemoglobinemia observed at the admission (80%) disappeared only at day 11, and hemolysis appeared at day 4 and decreased slowly to day 12. Metobromuron was analyzed by liquid chromatography with diode-array detection. Initial plasma concentration and elimination half-life were 4.9 mg/L and 5 h, respectively. Several metabolites were also detected, and four of those were identified by liquid chromatography-electrospray mass spectrometry. Normetobromuron, bromophenylurea, and bromoacetanilide were detected in plasma, but only N-methyl bromophenylurea was detected in urine. Bromoacetanilide probably results from acetylation of the intermediate bromoaniline. Methemoglobinemia could result from metabolization of metobromuron to bromoaniline and bromoacetanilide.  (+info)

(3/292) Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.

Acetochlor [2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)-acetamide], alachlor [N-(methoxymethyl)-2-chloro-N-(2, 6-diethyl-phenyl)acetamide], butachlor [N-(butoxymethyl)-2-chloro-N-(2,6-diethyl-phenyl)acetamide], and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] are pre-emergent herbicides used in the production of agricultural crops. These herbicides are carcinogenic in rats: acetochlor and alachlor cause tumors in the nasal turbinates, butachlor causes stomach tumors, and metolachlor causes liver tumors. It has been suggested that the carcinogenicity of these compounds involves a complex metabolic activation pathway leading to a DNA-reactive dialkylbenzoquinone imine. Important intermediates in this pathway are 2-chloro-N-(2,6-diethylphenyl)acetamide (CDEPA) produced from alachlor and butachlor and 2-chloro-N-(2-methyl-6-ethylphenyl)acetamide (CMEPA) produced from acetochlor and metolachlor. Subsequent metabolism of CDEPA and CMEPA produces 2,6-diethylaniline (DEA) and 2-methyl-6-ethylaniline (MEA), which are bioactivated through para-hydroxylation and subsequent oxidation to the proposed carcinogenic product dialkylbenzoquinone imine. The current study extends our earlier studies with alachlor and demonstrates that rat liver microsomes metabolize acetochlor and metolachlor to CMEPA (0.065 nmol/min/mg and 0.0133 nmol/min/mg, respectively), whereas human liver microsomes can metabolize only acetochlor to CMEPA (0.023 nmol/min/mg). Butachlor is metabolized to CDEPA to a much greater extent by rat liver microsomes (0.045 nmol/min/mg) than by human liver microsomes (< 0.001 nmol/min/mg). We have determined that both rat and human livers metabolize both CMEPA to MEA (0.308 nmol/min/mg and 0.541 nmol/min/mg, respectively) and CDEPA to DEA (0.350 nmol/min/mg and 0.841 nmol/min/mg, respectively). We have shown that both rat and human liver microsomes metabolize MEA (0.035 nmol/min/mg and 0.069 nmol/min/mg, respectively) and DEA (0.041 nmol/min/mg and 0.040 nmol/min/mg, respectively). We have also shown that the cytochrome P450 isoforms responsible for human metabolism of acetochlor, butachlor, and metolachlor are CYP3A4 and CYP2B6.  (+info)

(4/292) Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys.

The central nervous system toxicities of etidocaine, bupivacaine, and lidocaine were studied during constant-rate intravenous infusions in rhesus monkeys. Comparison of drug effects was achieved by determining the drug dosages and arterial plasma concentrations that induced electrical seizure activity. The central nervous system toxicity of etidocaine was similar to that of bupivacaine. The toxicity of each was four times greater than that of lidocaine. Since the drug infusion rates were proportional to anesthetic potencies in clinical usage, the therapeutic-toxic ratios of these three drugs are similar.  (+info)

(5/292) Isolation of an inducible amidase from Pseudomonas acidovorans AE1.

A bacterial strain, AEI, which hydrolysed acetanilide, was isolated from soil and identified as Pseudomonas acidovorans. Numerous amides, esters and enzyme inhibitors were tested as amidase inducers. Phenacetin was chosen as inducer for the large scale cultivation of these organisms because it was less toxic to the bacteria than acetanilide. The induction increased the enzymic activity 250-fold. In comparison, the type culture strain of P. acidovorans, ATTCCI5668, had no amidase activity which could be induced by phenacetin. Optimal growth conditions were established with respect to the concentration of carbon source and inducer so that about 10% of the extractable bacterial protein consisted of the amidase. The organisms were lysed with lysozyme in the presence of EDTA and the enzyme was isolated mainly by column chromatography procedures. A preparation form 60 g (wet wt) bacteria yielded about 100 mg highly purified amidase with a specific activity of 137 mugmol substrate hydrolysed/min/mg protien. In addition to acetanilide, the purified enzyme hydrolysed several other amides and esters. As standard substrate, p-nitroacetanilide was chosen.  (+info)

(6/292) Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease.

Previously, we established a method to assess drug metabolism capacity based on a pharmacokinetic estimation of the quantity of cytochrome P450 (CYP) in vivo (PKCYP-test) by introducing an apparent liver-to-blood free concentration gradient in vivo (qg). The qg values were determined as the ratio of in vivo-in vitro clearance. In this study, we examined the application of the PKCYP-test to the clearance of acetanilide and caffeine mediated by CYP1A2 using rat models in which the levels of CYP enzymes were reduced. Rats fed a choline-deficient diet (CD-fed) and aged rats were used as models for a low level of CYP in the liver. In both rat models, the contribution (fCYP) of CYP1A2 to the in vivo intrinsic clearance values (CLint) of acetanilide and caffeine metabolism was less than unity, suggesting that other metabolic pathways are involved in the CLint. The in vivo clearance for CYP1A2 was estimated by multiplying fCYP by CLint, then the value of qg was determined as the ratio of in vivo-in vitro clearance. We predicted the level of CYP1A2 in CD-fed and aged rats, based on the clearance of acetanilide mediated by CYP1A2, using the qg value of control rats. The clearance of caffeine mediated by CYP1A2 in CD-fed and aged rats, as estimated from the predicted level of CYP1A2, correlated with the observed values. In conclusion, we have demonstrated that the PKCYP-test can be applied to CYP1A2 for drugs metabolized by multiple CYP isozymes, and/or to models involving reduced CYP.  (+info)

(7/292) Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.

Acetaminophen (AAP), a widely used analgesic drug, can damage various organs when taken in large doses. In this study, we investigate whether AAP causes cell damage by altering the early signaling pathways associated with cell death and survival. AAP caused time- and concentration-dependent apoptosis and DNA fragmentation of C6 glioma cells used as a model. AAP activated c-Jun N-terminal protein kinase (JNK) by 5.3-fold within 15 min. The elevated JNK activity persisted for up to 4 h before it returned to the basal level at 8 h. In contrast, activities of other mitogen-activated protein (MAP) kinases and the level of Akt phosphorylation in the cell survival pathway remained unchanged throughout the treatment. Wortmannin, an inhibitor of phosphatidylinositol-3 kinase, or SB203580, an inhibitor of p38 MAP kinase, did not reduce AAP-induced toxicity, indicating that these enzymes do not play a major role in cell toxicity. AAP-induced apoptosis was preceded by the sequential elevation of the pro-apoptotic Bax protein, cytochrome c release, and caspase-3 activity. Treatment with caspase inhibitor benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethyl ketone (Z-DEVD-FMK) significantly reduced AAP-induced caspase-3 activation and cytotoxicity. Transfection of cDNA for the dominant-negative mutant JNK-KR or stress-activated protein kinase kinase-1 Lys-->Arg mutant (SEK1-KR), an immediate upstream kinase of JNK, significantly reduced AAP-induced JNK activation and cell death rate. The noncytotoxic analog of AAP, 3-hydroxyacetanilide, neither increased JNK activity nor caused apoptosis. Pretreatment with YH439, an inhibitor of CYP2E1 gene transcription, markedly reduced CYP2E1 mRNA, protein content, and activity, as well as the rate of AAP-induced JNK activation and cell death. These data indicate that AAP can cause cell damage by activating the JNK-related cell death pathway, providing a new mechanism for AAP-induced cytotoxicity.  (+info)

(8/292) Posttranslational modification of the umuD-encoded subunit of Escherichia coli DNA polymerase V regulates its interactions with the beta processivity clamp.

The Escherichia coli umuDC (pol V) gene products participate in both a DNA damage checkpoint control and translesion DNA synthesis. Interactions of the two umuD gene products, the 139-aa UmuD and the 115-aa UmuD' proteins, with components of the replicative DNA polymerase (pol III), are important for determining which biological role the umuDC gene products will play. Here we report our biochemical characterizations of the interactions of UmuD and UmuD' with the pol III beta processivity clamp. These analyses demonstrate that UmuD possesses a higher affinity for beta than does UmuD' because of the N-terminal arm of UmuD (residues 1-39), much of which is missing in UmuD'. Furthermore, we have identified specific amino acid residues of UmuD that crosslink to beta with p-azidoiodoacetanilide, defining the domain of UmuD important for the interaction. We have recently proposed a model for the solution structure of UmuD(2) in which the N-terminal arm of each protomer makes extensive contacts with the C-terminal globular domain of its intradimer partner, masking part of each surface. Taken together, our findings suggest that UmuD(2) has a higher affinity for the beta-clamp than does UmuD'(2) because of the structures of its N-terminal arms. Viewed in this way, posttranslational modification of UmuD, which entails the removal of its N-terminal 24 residues to yield UmuD', acts in part to attenuate the affinity of the umuD gene product for the beta-clamp. Implications of these structure-function analyses for the checkpoint and translesion DNA synthesis functions of the umuDC gene products are discussed.  (+info)

*  Acetanilide
The observed methemoglobinemia after acetanilide administration was ascribed to the small proportion of acetanilide that is ... Acetanilide . See, e.g., The preparation of acetanilide from aniline, Department of Chemistry, University of the West Indies at ... "Metabolic fate of acetanilide and other aniline derivatives. II. Major metabolites of acetanilide in the blood", J. Pharmacol. ... Acetanilide is an odourless solid chemical of leaf or flake-like appearance. It is also known as N-phenylacetamide, acetanil, ...
*  Coal tar
These included acetanilide, phenacetin, and paracetamol (acetaminophen). Paracetamol is the only coal-tar derived analgesic ...
*  Butachlor
... is a herbicide of the acetanilide class. It is used as a selective pre-emergent herbicide. It is extensively used in ...
*  David Lester (biochemist)
Of far greater impact was the second paper in this series, showing that paracetamol was a metabolite of acetanilide in the ... Major metabolites of acetanilid appearing in the blood". Journal of Pharmacology and Experimental Therapeutics. 90 (1): 68-75. ... In 1946-1947, while studying at Yale, he coauthored with Leon Greenberg a series of three papers on acetanilide, an analgesic ... L.A. Greenberg; D. Lester (1947). "The metabolic fate of acetanilid and other aniline derivatives III. The role of p- ...
*  Patent medicine
"Metabolic fate of acetanilide and other aniline derivatives. II. Major metabolites of acetanilide in the blood", J. Pharmacol. ... Acetanilide is no longer used as a drug in its own right, although the success of its metabolite - paracetamol (acetaminophen ... But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not ... Ther., 90 (1): 68, PMID 20241897 . Brodie, B. B.; Axelrod, J. (1948), "The fate of acetanilide in man" (PDF), J. Pharmacol. Exp ...
*  2-Nitroaniline
C6H5NH2 + (CH3CO)2O → C6H5NHC(O)CH3 + CH3CO2H In the next step, the acetanilide is nitrated: C6H5NHC(O)CH3 + HNO3 → O2NC6H4NHC( ... One method of preparing o-nitroaniline is via acetanilide. First, aniline acetylated with acetic anhydride. ...
*  Reaction inhibitor
Added acetanilide slows the decomposition of drug-store hydrogen peroxide solution, inhibiting the reaction 2H 2O 2 → 2H 2O + O ... About acetanilide The decomposition of hydrogen peroxide. ...
*  Crabtree's catalyst
Hesk, D.; Das, P.; Evans, B. (1995). "Deuteration of acetanilides and other substituted aromatics using [Ir(COD)(Cy3P)(Py)]PF6 ...
*  Nitroacetanilide
4-Nitroacetanilide is a chemical compound which is a nitro derivative of acetanilide. There are two other isomers of ...
*  Bernard Brodie (biochemist)
Together with Julius Axelrod, he discovered that acetanilide and phenacetin both metabolize to paracetamol. Unlike its ...
*  Bromo-Seltzer
Early formulas also used, as the analgesic ingredient, acetanilide, now known as a poisonous substance. Bromo-Seltzer's main ...
*  Paracetamol
Acetanilide was the first aniline derivative serendipitously found to possess analgesic as well as antipyretic properties, and ... However, unlike phenacetin, acetanilide and their combinations, paracetamol is not considered carcinogenic at therapeutic doses ... In 1947 David Lester and Leon Greenberg found strong evidence that paracetamol was a major metabolite of acetanilide in human ... Paracetamol is the active metabolite of phenacetin and acetanilide, both once popular as analgesics and antipyretics in their ...
*  Tamibarotene
Aluminum chloride mediated Friedel-Crafts alkylation of acetanilide with the dichloride affords the tetralin (3). Basic ...
*  Julius Axelrod
Axelrod and Brodie discovered that acetanilide, the main ingredient of these pain-killers, was to blame. They found that one of ...
*  Aniline
The amides formed from aniline are sometimes called anilides, for example CH3-CO-NH-C6H5 is acetanilide. At high temperatures ...
*  Vanadyl nitrate
Benzene, toluene, tert-butylbenzene, halo-benzenes, ortho-nitrotoluene, anisole, phenol and acetanilide are all rapidly ... acetanilide, benzoic acid, ethyl benzoate, and toluene. Vanadyl nitrate can be made by soaking vanadium pentoxide in liquid ...
*  Nitration
According to another source a more controlled nitration of aniline starts with the formation of acetanilide by reaction with ...
*  List of MeSH codes (D02)
... acetanilides MeSH D02.065.199.092.040 --- acetaminophen MeSH D02.065.199.092.250 --- diamfenetide MeSH D02.065.199.092.325 --- ...
*  Controlled Drugs and Substances Act
... acetanilide) Alfentanil (N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl] ...
*  NAPQI
Acetanilide and Phenacetin http://emedicine.medscape.com/article/820200-overview http://pubs.niaaa.nih.gov/publications/arh23-1 ...
*  Beckmann rearrangement
... industrial synthesis of paracetamol developed by Hoechst-Celanese involves the conversion of a methyl ketone to an acetanilide ...
*  United States v. Johnson (1911)
... or acetanilide or any derivative or preparation of any such substances Pure Food and Drug Act, ch. 3915, 34 Stat. 768 (1906) ( ...
*  Lumière-Barbier method
The acetanilide product is insoluble in water and can therefore be filtered off as crystals. Schotten-Baumann reaction Clayden ...
Unscramble acetanilid | Words unscrambled from letters acetanilid | Scrabble Word acetanilid | Words Made with the Letters...  Unscramble acetanilid | Words unscrambled from letters acetanilid | Scrabble Word acetanilid | Words Made with the Letters...
Unscramble acetanilid, Unscramble letters acetanilid, Point value for acetanilid, Word Decoder for acetanilid, Word generator using the letters acetanilid, Word Solver acetanilid, Possible Scrabble words with acetanilid, Anagram of acetanilid
more infohttp://www.allscrabblewords.com/word-description/acetanilid
THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL...  THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL...
Methods are described for the determination of acetanilide and its metabolites. The procedure for acetanilide permits estimation of as little as 4 micrograms of the compound, that for aniline as little as 0.25 micrograms, for N-acetyl p-aminophenol and total conjugated p-aminophenol as little as 10 micrograms.. A comparison of the solubility characteristics of the authentic compounds and the apparent compounds extracted from the plasma and urine of subjects receiving acetanilide, indicates that the methods have a high degree of specificity.. ...
more infohttp://jpet.aspetjournals.org/content/94/1/22.short
Preparation of Acetanilide Essay - 433 Words  Preparation of Acetanilide Essay - 433 Words
Synthesis of Acetanilide Reaction O NH2 H3C C O O C CH3 O N C CH3 H H3C O C OH Aniline Acetic anhydride Acetanilide Acetic acid Purpose: Acetanilide is a
more infohttp://www.studymode.com/essays/Preparation-Of-Acetanilide-1533426.html
Acetanilide dictionary definition | acetanilide defined  Acetanilide dictionary definition | acetanilide defined
acetanilide definition: a white, crystalline organic substance, CHNHCOCH, produced by the action of acetic acid on aniline: it is used as a drug to lessen pain and fever, in making dyes, etc.Origin of acetanilide acet(o)- + anil(ine) + -ide...
more infohttp://www.yourdictionary.com/acetanilide
4-Amino-3-(trifluoromethyl)acetanilide 1579-89-1 H-NMR | C-NMR Spectral Analysis   NMR Spectrum  4'-Amino-3'-(trifluoromethyl)acetanilide 1579-89-1 H-NMR | C-NMR Spectral Analysis NMR Spectrum
4'-Amino-3'-(trifluoromethyl)acetanilide 1579-89-1 NMR spectrum, 4'-Amino-3'-(trifluoromethyl)acetanilide H-NMR spectral analysis, 4'-Amino-3'-(trifluoromethyl)acetanilide C-NMR spectral analysis ect.
more infohttp://www.molbase.com/en/hnmr_1579-89-1-moldata-34996.html
3-(N,N-Diethylamino)acetanilide 6375-46-8 H-NMR | C-NMR Spectral Analysis   NMR Spectrum  3-(N,N-Diethylamino)acetanilide 6375-46-8 H-NMR | C-NMR Spectral Analysis NMR Spectrum
3-(N,N-Diethylamino)acetanilide 6375-46-8 NMR spectrum, 3-(N,N-Diethylamino)acetanilide H-NMR spectral analysis, 3-(N,N-Diethylamino)acetanilide C-NMR spectral analysis ect.
more infohttp://www.molbase.com/en/hnmr_6375-46-8-moldata-6652.html
Room temperature palladium-catalyzed decarboxylative ortho-acylation of acetanilides with alpha-oxocarboxylic acids.  Room temperature palladium-catalyzed decarboxylative ortho-acylation of acetanilides with alpha-oxocarboxylic acids.
A novel Pd-catalyzed decarboxylative ortho-acylation of acetanilides with alpha-oxocarboxylic acids is realized at room temperature. This reaction provides efficient access to o-acyl acetanilides under mild conditions.
more infohttp://www.biomedsearch.com/nih/Room-Temperature-Palladium-Catalyzed-Decarboxylative/20698536.html
What are the wavelengths of the IR spectra for Acetanilide? | Reference.com  What are the wavelengths of the IR spectra for Acetanilide? | Reference.com
Wavelengths of spectra for Acetanilide ranges from 3300 cm-1 to 1700 cm-1. This is because of the bonds that are formed within the Acentanilide chemical...
more infohttps://www.reference.com/science/wavelengths-ir-spectra-acetanilide-d6989bf5c0282512
Stepwise microhydration of aromatic amide cations: water solvation networks revealed by the infrared spectra of acetanilide+-...  Stepwise microhydration of aromatic amide cations: water solvation networks revealed by the infrared spectra of acetanilide+-...
The structure and activity of peptides and proteins strongly rely on their charge state and the interaction with their hydration environment. Here, infrared photodissociation (IRPD) spectra of size-selected microhydrated clusters of cationic acetanilide (AA+, N-phenylacetamide), AA+-(H2O)n with n ≤ 3, are an Complex molecular systems: supramolecules, biomolecules and interfaces
more infohttp://pubs.rsc.org/en/content/articlelanding/2017/cp/c7cp04659f/unauth
Acetanilide Import Data and Price in USA  Acetanilide Import Data and Price in USA
View details of Acetanilide import data and shipment reports in US with product description, price, date, quantity, major us ports, countries and buyer, supplier.
more infohttps://www.seair.co.in/us-import/product-acetanilide.aspx
Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties | Circulation  Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties | Circulation
The effects of ranolazine on cardiac ion currents at concentrations within the therapeutic range (ie, 2 to 6 μmol/L) include inhibition of IKr, late INa, and late ICa,L. Inhibition of IKr by ranolazine prolongs APD, and its effect to inhibit late INa and late ICa,L abbreviates APD. The net effect and clinical consequence of inhibition of these ion channel currents is a modest increase in the mean QTc interval over the therapeutic range. The drug differs significantly from other agents that block IKr and induce TdP. Ranolazine-induced prolongation of the APD is rate independent (ie, does not display reverse rate-dependent prolongation of APD) and is not associated with EADs, triggered activity, an increase in spatial dispersion of repolarization, or polymorphic ventricular tachycardia. Indeed, rather than displaying arrhythmogenic activity, ranolazine, via its actions to suppress EADs and reduce TDR, possesses significant antiarrhythmic activity, acting to suppress the arrhythmogenic effects ...
more infohttp://circ.ahajournals.org/content/110/8/904
Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine - Research Collection  Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine - Research Collection
Heart failure is a leading cause of cardiovascular mortality with limited options for treatment. We analyzed whether the anti-ischemic drug ranolazine could retard the progression of heart failure in an experimental model of heart failure induced by 6 months of chronic pressure overload. The study showed that 2 months of ranolazine treatment improved cardiac function of aortic constricted C57BL/6J (B6) mice with symptoms of heart failure as assessed by echocardiography. The microarray gene expression study of heart tissue from failing hearts relative to ranolazine-treated and healthy control hearts identified heart failure-specific genes that were normalized during treatment with the anti-ischemic drug ranolazine Show more ...
more infohttps://www.research-collection.ethz.ch/handle/20.500.11850/159372
Qualitatively assessing melting/boiling points. | Physics Forums - The Fusion of Science and Community  Qualitatively assessing melting/boiling points. | Physics Forums - The Fusion of Science and Community
Of the 6, acetanilide and aniline will have the highest melting points as they are polar. Between the two, I reasoned that acetanilide will have a higher melting point because it has a polar carbonyl group in addition to the h-bonding provided by the nitrogen bonded to a hydrogen. This stands in contrast to the mere nitrogen bonded to two hydrogens in the aniline. I have to admit, my reasoning here is fuzzy. As it stands, I'm comparing carbonyl & N-H (acetanilide) to N-H & N-H (aniline). How do we know that dipole + hydrogen bonding is better than hydrogen bonding + hydrogen bonding? I know that hydrogen bonding is a stronger intermolecular interaction than dipole-dipole or dipole-hydrogen bond ...
more infohttps://www.physicsforums.com/threads/qualitatively-assessing-melting-boiling-points.694725/
Anilinium hydrochloride intermediate formation | Physics Forums - The Fusion of Science and Community  Anilinium hydrochloride intermediate formation | Physics Forums - The Fusion of Science and Community
thats if you want to run this reaction by 'one step formation reaction',..i mean if you want to obtain Acetanilide from Aniline this is the only step you should take over..but if you mean anything else the 'chemistry converting puzzle'(obtaining Acetanilide from Anillinium Hydrochloride) it would certainly differ..we should first eliminate the (-NH3+Cl-) group from the benzene ring..by a very strong agent and under extreme conditions..then from benzene we will obtain the Aniline easily from sand-mayer rx, then finally we would reach the final normal step of Acetanilide formation that i told you about it (rx with Acetyl Chloride ...
more infohttps://www.physicsforums.com/threads/anilinium-hydrochloride-intermediate-formation.228074/
Ranolazine for Congenital and Acquired Late INa-Linked ArrhythmiasNovelty and Significance | Circulation Research  Ranolazine for Congenital and Acquired Late INa-Linked ArrhythmiasNovelty and Significance | Circulation Research
Recently, there has been interest in the antiarrhythmic potential of the novel antianginal agent, ranolazine, the first Food and Drug Administration-approved drug that specifically blocks the late component of the Na+ current. Like most antiarrhythmics that target cardiac ion channels (eg, flecainide and amiodarone), ranolazine blocks multiple channels, including the repolarizing hERG current IKr, with therapeutic concentrations. The result is a mild concentration-dependent QTc prolongation seen in patients with chronic stable angina.11 Because of this, ranolazine is contraindicated for patients using other QT-prolonging drugs, those with preexisting QT prolongation,12 and those with repolarization abnormalities.. In this study, we sought to use a computationally based approach to determine whether ranolazine's unintended pathological block of promiscuous K+ channels would prevail over therapeutic drug effects in 2 specific patient populations: LQT3-ΔKPQ carriers and those with acquired ...
more infohttp://circres.ahajournals.org/content/113/7/e50
MERLIN-TIMI 36 | Article about MERLIN-TIMI 36 by The Free Dictionary  MERLIN-TIMI 36 | Article about MERLIN-TIMI 36 by The Free Dictionary
Looking for MERLIN-TIMI 36? Find out information about MERLIN-TIMI 36. in Arthurian legend Arthurian legend, the mass of legend, popular in medieval lore, concerning King Arthur of Britain and his knights. Medieval Sources The... Explanation of MERLIN-TIMI 36
more infohttp://encyclopedia2.thefreedictionary.com/MERLIN-TIMI+36
Clinical Summaries | Circulation  Clinical Summaries | Circulation
Ranolazine is a novel antianginal that may also have a favorable effect on hemoglobin A1c (HbA1c). We designed a prospective evaluation of the effect of ranolazine on hyperglycemia as part of the randomized, double-blind, placebo-controlled Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) trial and compared HbA1c (percentage) among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo. We found that ranolazine significantly reduced HbA1c at 4 months compared with placebo in patients with and without diabetes mellitus. In patients with diabetes mellitus treated with ranolazine, HbA1c declined 0.64% (P,0.001). In addition, diabetic patients treated with ranolazine were more likely to achieve an HbA1c ,7% at 4 months (P,0.001). Notably, in patients without diabetes mellitus at baseline, the incidence of new fasting glucose ,110 mg/dL or HbA1c ≥6% was reduced by 32% ...
more infohttp://circ.ahajournals.org/content/119/15/2017
Plus it  Plus it
The time course of oxidative metabolism of pentobarbital and acetanilide by rat liver microsomes is linear for relatively short periods of time. This early deviation from linearity is accompanied by a high rate of NADPH-dependent lipid peroxidation and breakdown of the heme of cytochrome P-450, the terminal oxidase for the microsomal metabolism of foreign compounds, steroids, and fatty acids. The addition of EDTA to the incubation mixture prevents both lipid peroxidation and the decrease in cytochrome P-450 levels, and extends the linearity of pentobarbital and acetanilide metabolism. In contrast, chlorcyclizine, a substrate which blocks lipid peroxidation, is N-demethylated at a constant rate for at least 30 min. Furthermore, a constant rate of pentobarbital metabolism is observed for a prolonged period in the absence of EDTA when rabbit liver microsomes are used. This correlates with the absence of any appreciable lipid peroxidation and hemoprotein breakdown by NADPH in rabbit liver ...
more infohttp://dmd.aspetjournals.org/content/1/6/766
Simple Accordion with CSS & jQuery by Soh Tanaka  Simple Accordion with CSS & jQuery by Soh Tanaka
The crude p-acetaminobenzenesulfonyl chloride (p. 8) obtained from 67.5 g. (0.5 mole) of acetanilide is shaken for two hours with a solution of 252 g. (1 mole) of crystallized sodium sulfite (Na2SO3 · 7H2O) in 500 cc. of water. The reaction mixture is kept slightly alkaline by the addition at intervals of small portions of 50 per cent sodium hydroxide solution. The total volume of alkali used varies from 10 to 50 cc. After the alkaline mixture has been shaken for the two-hour period (Note 1) it is filtered, and the filtrate is acidified with 60 per cent sulfuric acid. If the acid is added slowly, the sulfinic acid comes down in fine crystals which, after filtering and drying, melt at 155° with decomposition (Note 2). The yield is 50-55 g.. (43-47 per cent of the theoretical amount based on the acetanilide used ...
more infohttp://www.orgsyn.org/demo.aspx?prep=cv1p0007
repository:General Surgery found 3093 records • Museum of Health Care at Kingston  repository:General Surgery found 3093 records • Museum of Health Care at Kingston
This bottle contains a mixture of Acetanilide and Lysol. Acetanilide is a compound drug used for fever-reducing since 1886 as an alternative to aspirin for treating headaches, cramps, and rheumatism. It does have toxic side effects from prolonged use such as complicating the function of hemoglobin. Lysol was first used in Germany in 1889 to end a cholera epidemic. It is a mixture of soap with cresols as an antiseptic. Before its use as a cleaner, it has been used as a poison, to treat the Spanish flu of 1918, and as a method of birth control in women in the 1920s. This bottle is half-filled with the liquid ...
more infohttp://mhc.andornot.com/en/list?q=%2Brepository%3AGeneral%20Surgery&p=1&ps=20&sort=title_sort%20asc
Acetanilide Formula, Preparation, Melting Point, Solubility, MSDS | Chemistry Learner  Acetanilide Formula, Preparation, Melting Point, Solubility, MSDS | Chemistry Learner
Eye Contact: Any contact lenses should be removed immediately in case of accidental eye contact. One should flush the eyes with plenty of water at least for 15 minutes. Immediate medical aid is required.. Skin Contact: Victim should wash the contaminated skin area with disinfectant soap and water before applying an emollient lotion to it. It is important to get immediate medical assistance.. Inhalation: The victim should be removed to fresh air in case of accidental inhalation of this powder. Oxygen and artificial respiration should be provided in case the victim is experiencing breathing problems. One should immediately seek medical attention.. Ingestion: It is not advisable to induce vomiting without proper direction from a qualified physician. Any tight clothing like tie, collar and waistband should be loosened. One should never give anything by mouth if the victim is unconscious. Immediate medical assistance is important.. ...
more infohttp://www.chemistrylearner.com/acetanilide.html?replytocom=50129
Category:Acetanilides - Wikimedia Commons  Category:Acetanilides - Wikimedia Commons
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
more infohttps://commons.wikimedia.org/wiki/Category:Acetanilides
NOPR: Butachlor is cytotoxic and clastogenic and induces apoptosis in mammalian cells  NOPR: Butachlor is cytotoxic and clastogenic and induces apoptosis in mammalian cells
The ability of butachlor to induce cytotoxicity, clastogenicity and DNA damage was assessed using Chinese hamster ovary cells (CHO), Swiss mouse embryo fibroblasts (MEF) and human peripheral blood lymphocytes. A dose and time dependent loss of viability was evident upon treatment of CHO cells with butachlor. Cell killing to an extent of 50 % was observed when cells were treated with 16.2 μg/ml of butachlor for 24 hr or with 11.5 μg/ml for 48 hr. The herbicide induced micronuclei significantly in cultured lymphocytes at 24 and 48 hr of treatment suggesting that it is clastogenic. To understand the mechanism of cell death caused by butachlor, its effect on DNA strand breaks was studied in MEF. A concomitant decrease in cell viability was observed with increase in DNA strand breaks. Agarose gel electrophoresis of DNA from herbicide treated CHO cells and cytochemical staining indicate the induction of apoptosis by butachlor ...
more infohttp://nopr.niscair.res.in/handle/123456789/19142
Ranolazine for Improving Symptoms of Palpitations - Full Text View - ClinicalTrials.gov  Ranolazine for Improving Symptoms of Palpitations - Full Text View - ClinicalTrials.gov
Background:. Patients with ischemic heart disease often report multiple symptoms, including angina and palpitations.. Ranolazine is a novel antianginal and antiischemic drug that reduces intracellular sodium and calcium accumulation during ischemia thus limiting ischemic injury. Furthermore, ranolazine has antiarrhythmic effects which are largely a result of the drug's effect on multiple ion channels.. It has previously been shown that treatment with ranolazine can reduce the frequency of supraventricular and ventricular tachycardia in the short term. In a subgroup analysis of the MERLIN-TIMI 36 trial, the continuous ECGs of 6,351 patients were analyzed. The results showed that, in comparison with placebo, treatment with ranolazine resulted in fewer episodes of ventricular tachycardia that lasted 8 beats or longer (5.3% versus 8.3%; P ,0.001), and in fewer episodes of supraventricular tachycardia (44.7% versus 55%; P ,0.001) and new-onset atrial fibrillation (1.7% versus 2.4%; P=0.08).. It ...
more infohttps://clinicaltrials.gov/show/NCT01495520
Abstract 1798: B-type Natriuretic Peptide and the Effect of Ranolazine in Patients with Non-ST Elevation Acute Coronary...  Abstract 1798: B-type Natriuretic Peptide and the Effect of Ranolazine in Patients with Non-ST Elevation Acute Coronary...
Ranolazine is believed to exert anti-ischemic effects by reducing myocardial cellular Na+ & Ca2+ overload and consequently LV wall stress. B-type natriuretic peptide (BNP) rises in response to increased wall stress and is a potent indicator of risk in ACS. Thus, we designed a prospective evaluation of the interaction between BNP and the effect of ranolazine as part of a randomized, blinded, placebo-controlled trial.. METHODS: We measured plasma BNP (ADVIA BNP) at baseline (N = 4543) in pts with non-ST elevation ACS randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial. Pts were stratified using BNP ,80 pg/ml based on prior work. The 1o endpoint was a composite of cardiovascular death, myocardial infarction, or recurrent ischemia (CVD/MI/RI).. RESULTS: Pts with an elevated BNP (N = 1935) were at significantly higher risk of CVD/MI/RI (26.4% vs. 20.4%, p , 0.0001), CVD/MI (16.2% vs. 7.5%, p,0.0001) and CVD alone (9.0% vs. 2.4%, p,0.0001). In pts with BNP,80 pg/ml, ranolazine reduced the ...
more infohttp://circ.ahajournals.org/content/116/Suppl_16/II_382.4
  • Grain is protected from injury by 2-chloro-2',6'-diethyl-N-(methoxymethyl)acetanilide (alachlor) by coating the seeds prior to planting with a non-phytotoxic quantity of one of a small group of specific compounds. (freepatentsonline.com)
  • The relative importance of the underground shoot parts (hypocotyl) and roots of sunflower (Helianthus annuus L.) seedlings on the absorption of alachlor [a-chloro-2′,6′-diethyl- N-(methoxymethyl) acetanilide] was studied in a glasshouse experiment. (nisc.co.za)
  • The tolerance to alachlor [α-chloro-2′,6′?diethyl-N-(metoxy- methyl) acetanilide] of three sunflower (Helianthus annuus L.) cultivars was evaluated in an aqueous medium in a glass- house. (nisc.co.za)