A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
Oxidoreductases that are specific for ALDEHYDES.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Organic compounds containing a carbonyl group in the form -CHO.
A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).
Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
Experiments designed to determine the potential toxic effects of one-time, short-term exposure to a chemical or chemicals.
Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.
A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Persons who have a history of physical or psychological dependence on ETHANOL.
Agencies of the FEDERAL GOVERNMENT of the United States.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
A genus of gram-negative, aerobic, motile bacteria that occur in water and soil. Some are common inhabitants of the intestinal tract of vertebrates. These bacteria occasionally cause opportunistic infections in humans.
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Books containing photographs, prints, drawings, portraits, plates, diagrams, facsimiles, maps, tables, or other representations or systematic arrangement of data designed to elucidate or decorate its contents. (From The ALA Glossary of Library and Information Science, 1983, p114)
Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.
Procedures outlined for the care of casualties and the maintenance of services in disasters.
Large vessels propelled by power or sail used for transportation on rivers, seas, oceans, or other navigable waters. Boats are smaller vessels propelled by oars, paddles, sail, or power; they may or may not have a deck.
A human liver tumor cell line used to study a variety of liver-specific metabolic functions.
An antineoplastic agent derived from BLEOMYCIN.
Tumors or cancer of the LIVER.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A cell line derived from cultured tumor cells.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Ciprofloxacin decreases the rate of ethanol elimination in humans. (1/696)

BACKGROUND: Extrahepatic ethanol metabolism is postulated to take place via microbial oxidation in the colon, mediated by aerobic and facultative anaerobic bacteria. AIMS: To evaluate the role of microbial ethanol oxidation in the total elimination rate of ethanol in humans by reducing gut flora with ciprofloxacin. METHODS: Ethanol was administered intravenously at the beginning and end of a one week period to eight male volunteers. Between ethanol doses volunteers received 750 mg ciprofloxacin twice daily. RESULTS: A highly significant (p=0.001) reduction in the ethanol elimination rate (EER) was detected after ciprofloxacin medication. Mean (SEM) EER was 107.0 (5.3) and 96.9 (4.8) mg/kg/h before and after ciprofloxacin, respectively. Faecal Enterobacteriaceae and Enterococcus sp. were totally absent after medication, and faecal acetaldehyde production capacity was significantly (p<0.05) decreased from 0.91 (0.15) to 0.39 (0.08) nmol/min/mg protein. Mean faecal alcohol dehydrogenase (ADH) activity was significantly (p<0. 05) decreased after medication, but ciprofloxacin did not inhibit human hepatic ADH activity in vitro. CONCLUSIONS: Ciprofloxacin treatment decreased the ethanol elimination rate by 9.4%, with a concomitant decrease in intestinal aerobic and facultative anaerobic bacteria, faecal ADH activity, and acetaldehyde production. As ciprofloxacin has no effect on liver blood flow, hepatic ADH activity, or cytochrome CYP2E1 activity, these effects are probably caused by the reduction in intestinal flora.  (+info)

Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol. (2/696)

Epidemiological studies suggest that there is a beneficial effect of moderate ethanol consumption on the incidence of cardiovascular disease. Ethanol is metabolized to acetaldehyde, a two-carbon carbonyl compound that can react with nucleophiles to form covalent addition products. We have identified a biochemical modification produced by the reaction of acetaldehyde with protein-bound Amadori products. Amadori products typically arise from the nonenzymatic addition of reducing sugars (such as glucose) to protein amino groups and are the precursors to irreversibly bound, crosslinking moieties called advanced glycation endproducts, or AGEs. AGEs accumulate over time on plasma lipoproteins and vascular wall components and play an important role in the development of diabetes- and age-related cardiovascular disease. The attachment of acetaldehyde to a model Amadori product produces a chemically stabilized complex that cannot rearrange and progress to AGE formation. We tested the role of this reaction in preventing AGE formation in vivo by administering ethanol to diabetic rats, which normally exhibit increased AGE formation and high circulating levels of the hemoglobin Amadori product, HbA1c, and the hemoglobin AGE product, Hb-AGE. In this model study, diabetic rats fed an ethanol diet for 4 weeks showed a 52% decrease in Hb-AGE when compared with diabetic controls (P < 0.001). Circulating levels of HbA1c were unaffected by ethanol, pointing to the specificity of the acetaldehyde reaction for the post-Amadori, advanced glycation process. These data suggest a possible mechanism for the so-called "French paradox," (the cardioprotection conferred by moderate ethanol ingestion) and may offer new strategies for inhibiting advanced glycation.  (+info)

Inhibition and stimulation of long-chain fatty acid oxidation by chloroacetaldehyde and methylene blue in rats. (3/696)

The effects of chloroacetaldehyde (CAA) and methylene blue, both alone and together, on mitochondrial metabolism, hepatic glutathione content, and bile flow were investigated in rats. Oxidation of [1-14C]palmitic acid, [1-14C]octanoic acid, and [1,4-14C]succinic acid allowed for the differentiation between carnitine-dependent long-chain fatty acid metabolism, medium chain fatty acid oxidation, and citric acid cycle activity, respectively. CAA, a metabolite of the anticancer drug ifosfamide, which may be responsible for ifosfamide-induced encephalopathy, inhibited palmitic acid metabolism but not octanoic or succinic acid oxidation, depleted hepatic glutathione, and stimulated bile flow. Methylene blue, which is clinically used to either prevent or reverse ifosfamide-associated encephalopathy, markedly stimulated palmitic acid oxidation either in the presence or absence of CAA, but did not affect the oxidation of octanoic and succinic acid or hepatic glutathione. Taken together, this study demonstrates that CAA inhibits palmitic acid metabolism. Methylene blue stimulates long-chain fatty acid oxidation, most likely by facilitating the translocation of fatty acids into mitochondria, and compensates for the CAA effect in vivo.  (+info)

Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry. (4/696)

NADPH is known to be tightly bound to mammalian catalase and to offset the ability of the substrate of catalase (H2O2) to convert the enzyme to an inactive state (compound II). In the process, the bound NADPH becomes NADP+ and is replaced by another molecule of NADPH. This protection is believed to occur through electron tunneling between NADPH on the surface of the catalase and the heme group within the enzyme. The present study provided additional support for the concept of an intermediate state of catalase, through which NADPH serves to prevent the formation (rather than increase the removal) of compound II. In contrast, the superoxide radical seemed to bypass the intermediate state since NADPH had very little ability to prevent the superoxide radical from converting catalase to compound II. Moreover, the rate of NADPH oxidation was several times the rate of compound II formation (in the absence of NADPH) under a variety of conditions. Very little NADPH oxidation occurred when NADPH was exposed to catalase, H2O2, or the superoxide radical separately. That the ratio exceeds 1 suggests that NADPH may protect catalase from oxidative damage through actions broader than merely preventing the formation of compound II.  (+info)

Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages. (5/696)

Very low density lipoproteins (VLDLs) from apolipoprotein (apo) E2/E2 subjects with type III hyperlipoproteinemia, VLDL remnants, and VLDL from apoE-knockout (EKO) mice are taken up poorly by macrophages. The present study examined whether VLDL modification by the reactive aldehyde p-hydroxyphenylacetaldehyde (pHA) enhances cholesteryl ester (CE) accumulation by J774A.1 macrophages. pHA is the major product derived from the oxidation of L-tyrosine by myeloperoxidase and is a component of human atherosclerotic lesions. Incubation of J774A.1 cells with native type III VLDL, their remnants, and EKO-VLDL increased cellular CE by only 3-, 5-, and 5-fold, respectively, compared with controls. In striking contrast, cells exposed to VLDL modified by purified pHA (pHA-VLDL) exhibited marked increases in cellular CE of 38-, 47-, and 35-fold, respectively (P95%, CE accumulation induced by copper-oxidized VLDL. These results demonstrate a novel mechanism for the conversion of type III VLDLs, their remnants, and EKO-VLDL into atherogenic particles and suggest that macrophage uptake of pHA-VLDL (1) requires catalytically active lipoprotein lipase, (2) involves acyl coenzyme A:cholesterol acyltransferase-mediated cholesterol esterification, and (3) involves pathways distinct from the SR-A.  (+info)

Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye. (6/696)

PURPOSE: To develop an antibody that recognizes a variety of advanced glycation endproduct (AGE) epitopes. METHODS: Glycolaldehyde was used to modify bovine serum albumin and HPLC analysis was used to measure pentosidine formation as an indicator of AGE formation. A polyclonal anti-AGE antibody was synthesized by injecting glycolaldehyde-incubated keyhole limpet hemocyanin into rabbits, affinity purified using AGE modified bovine serum albumin coupled to an affinity resin column, and characterized by immunoblot analysis. RESULTS: HPLC analysis of glycolaldehyde treated bovine serum albumin detected high levels of pentosidine formation, suggesting that glycolaldehyde is a potent precursor for pentosidine. By immunoblot analysis, our antibody recognized carboxymethyllysine and pentosidine, two well-characterized AGEs, as well as other AGE epitopes. Immunohistochemical evaluation showed evidence of AGEs in Bruch's membrane (including basal laminar deposits and drusen), choroidal extracellular matrix, and vessel walls in an 82 year old nondiabetic globe. A similar staining pattern was observed in an age-matched diabetic control. In contrast, no staining was seen with the antibody in a 20 month old nondiabetic globe. CONCLUSIONS: A unique anti-AGE antibody was synthesized that recognizes a variety of AGE epitopes including carboxymethyllysine and pentosidine. Its best use might be in broad surveys of the age-dependent accumulation of a large number of AGE epitopes that might not be revealed by antibodies to pentosidine or CML.  (+info)

The effect of inhibition of aldehyde dehydrogenase on nasal uptake of inspired acetaldehyde. (7/696)

At exposure concentrations of 750 ppm or more, acetaldehyde is a rodent inhalation carcinogen that induces nasal tumors. Aldehyde dehydrogenase (ALDH) is thought to be an important detoxifying enzyme for aldehydes. Although nasal tissues express ALDH, the importance of this enzyme relative to delivered dosage rates at high-inspired concentrations is not well defined. To provide such information, uptake of inspired acetaldehyde was measured at an inspiratory flow rate that approximated the minute ventilation rate in the surgically isolated nasal cavity of F 344 rats pretreated with either saline (control) or the ALDH inhibitor, cyanamide (10 mg/kg s.c.). ALDH activities (substrate concentration 3 times the K(m)) in anterior (respiratory mucosa) and posterior (olfactory mucosa) nasal tissues averaged 160 and 210 nmol/min), respectively, in control animals (total activity 370 nmol/min), compared to 60 and 80 nmol/min, respectively, in cyanamide-pretreated rats (p < 0.05), indicating that approximately 60% inhibition was obtained. Nasal uptake was measured at 3 inspired concentrations: 10, 300, and 1500 ppm. At these concentrations, acetaldehyde uptake efficiency averaged 54, 37, and 34% in saline-pretreated rats, respectively (p < 0.05). In absolute terms, the delivered dosage rates at these exposure concentrations averaged 21, 420, and 1990 nmol/min. The concentration dependence on uptake suggests a saturable process was involved. At inspired concentrations of 300 ppm or more, the delivered dosage rates exceeded the measured specific activity for nasal ALDH of 370 nmol/min. Cyanamide pretreatment abolished the concentration dependence. Specifically, uptake efficiencies in cyanamide-pretreated rats averaged 30, 27, and 31% at inspired concentrations of 10, 300, and 1500 ppm, respectively (p > 0.05); delivered dosage rates were 12, 310, and 1780 nmol/min. Thus, cyanamide pretreatment reduced nasal-delivered dosage rates at inspired concentrations of 10, 300, and 1500 ppm, respectively by 9, 110, and 210 nmol/min, values that correspond well with the total nasal ALDH activity of 370 nmol/min. In toto, these results suggest that inspired acetaldehyde is metabolized in situ by ALDH, but at exposure concentrations of 300 ppm or greater, the delivered dosage rate may equal or exceed the capacity of this enzyme.  (+info)

Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde. (8/696)

The P450 2E1-catalyzed oxidation of ethanol to acetaldehyde is characterized by a kinetic deuterium isotope effect that increases K(m) with no effect on k(cat), and rate-limiting product release has been proposed to account for the lack of an isotope effect on k(cat) (Bell, L. C., and Guengerich, F. P. (1997) J. Biol. Chem. 272, 29643-29651). Acetaldehyde is also a substrate for P450 2E1 oxidation to acetic acid, and k(cat)/K(m) for this reaction is at least 1 order of magnitude greater than that for ethanol oxidation to acetaldehyde. Acetic acid accounts for 90% of the products generated from ethanol in a 10-min reaction, and the contribution of this second oxidation has been overlooked in many previous studies. The noncompetitive intermolecular kinetic hydrogen isotope effects on acetaldehyde oxidation to acetic acid ((H)(k(cat)/K(m))/(D)(k(cat)/K(m)) = 4.5, and (D)k(cat) = 1.5) are comparable with the isotope effects typically observed for ethanol oxidation to acetaldehyde, and k(cat) is similar for both reactions, suggesting a possible common catalytic mechanism. Rapid quench kinetic experiments indicate that acetic acid is formed rapidly from added acetaldehyde (approximately 450 min(-1)) with burst kinetics. Pulse-chase experiments reveal that, at a subsaturating concentration of ethanol, approximately 90% of the acetaldehyde intermediate is directly converted to acetic acid without dissociation from the enzyme active site. Competition experiments suggest that P450 2E1 binds acetic acid and acetaldehyde with relatively high K(d) values, which preclude simple tight binding as an explanation for rate-limiting product release. The existence of a rate-determining step between product formation and release is postulated. Also proposed is a conformational change in P450 2E1 occurring during the course of oxidation and the discrimination of P450 2E1 between acetaldehyde and its hydrated form, the gem-diol. This multistep P450 reaction is characterized by kinetic control of individual reaction steps and by loose binding of all ligands.  (+info)

Conclusion: According to the results of this study, the significantly higher levels of salivary acetaldehyde production in oral cancer patients and individuals with poor dental health status may suggest a possible link between increased salivary acetaldehyde production and oral cancer. Improved oral hygiene can effectively decrease the level of salivary acetaldehyde production in oral cavity.. Key words: Oral cancer, salivary acetaldehyde production, oral hygiene, dental health status. Corresponding author: Bülent Eren, M.D., Associate Professor, Pathologist, Forensic Medicine Specialist, Council of Forensic Medicine of Turkey, Bursa Morgue Department; 16010, Bursa, Turkey, tel: +902242220347, fax: +0902242255170, e-mail: [email protected] Introduction. Excessive alcohol consumption is a significant risk factor for squamous cell carcinoma in the upper aeodigestive tract (UADT)1-7. There is increasing evidence that a majorpart of the tumour-promoting action of alcohol might be mediatedvia ...
ReportsnReports.com adds report 2014 Market Research Report on Global Acetaldehyde Industry to its store. 2014 Market Research Report on Global Acetaldehyde Industry is a professional and depth research report on Global Acetaldehyde industry that you would know the worlds major regional market conditions of Acetaldehyde industry, the main region including North American, Europe and Asia etc, and the main country including United States ,Germany ,Japan and China etc.. The report firstly introduced Acetaldehyde basic information including Acetaldehyde definition classification application and industry chain overview; Acetaldehyde industry policy and plan, Acetaldehyde product specification, manufacturing process, cost structure etc. Then we deeply analyzed the worlds main region market conditions that including the product price, profit, capacity, production, capacity utilization, supply, demand and industry growth rate etc.. Purchase Report Directly @ ...
Global Trimethyl Acetaldehyde Market 2016, presents a professional and in-depth study on the current state of the Trimethyl Acetaldehyde market globally, providing basic overview of Trimethyl Acetaldehyde market including definitions, classifications, applications and industry chain structure, Trimethyl Acetaldehyde Market report provides development policies and plans are discussed as well as manufacturing processes and cost structures. Trimethyl Acetaldehyde market size, share and end users are analyzed as well as segment markets by types, applications and companies.. Get Free Report Sample @ http://www.fiormarkets.com/report-detail/26446/request-sample. The market research report on Global Trimethyl Acetaldehyde Industry 2016, presents crucial information and statistical data about the Trimethyl Acetaldehyde market with respect to the world. The market report provides an overall analytical study of the Trimethyl Acetaldehyde market, taking growth drivers, restraints, and future prospects ...
A single point mutation in ALDH2-gene provides conclusive evidence for a causal relationship between acetaldehyde and upper GI tract cancer. Mutation results in deficient activity of the main acetaldehyde metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2). When drinking alcohol, ALDH2-deficients are exposed via saliva to 2-3 times and via gastric juice to 5-6 times higher acetaldehyde concentrations than individuals with active ALDH2-enzyme. Parallel to increased local acetaldehyde exposure, the risk of ALDH2-deficient alcohol drinkers for oral, pharyngeal, esophageal and gastric cancer is many fold compared to alcohol drinking ALDH2-actives. Based on strong gene-epidemiological and gene-biochemical evidence, the International Agency for Research on Cancer (IARC) has reclassified acetaldehyde associated with the consumption of alcoholic beverages as a group 1 human carcinogen. Equal gene mutation based human cancer model is not available for any other of the 118 group 1 human ...
Acetaldehyde is the first and principal metabolite of ethanol administered systemically. To its rise in blood, after administration of disulfiram, is ascribed the aversive reaction that should discourage alcoholics from drinking. In the present study, we sought to determine the effect of acetaldehyde on the electrophysiological properties of dopamine (DA)-containing neurons in the ventro tegmental area (VTA) of rats in vivo. Intravenous (i.v.) administration of acetaldehyde (5-40 mg/kg) readily and dose-dependently increased the firing rate, spikes/burst, and burst firing of VTA neurons. Ethanol (250-1000 mg/kg/i.v.) administration produced similar increments in electrophysiological parameters. In addition, a second group of rats was pretreated with the alcohol-dehydrogenase inhibitor 4-methyl-pyrazole (90 mg/kg) intraperitoneally (i.p.), and ethanol and acetaldehyde were administered i.v. at the same doses, 48 h later. In this group, ethanol effects were drastically reduced and the firing rate, ...
Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehydes psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanols central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is ...
The irreversible removal of acetaldehyde from indoor air via a chemical reaction with amino acids was investigated. To compare effectiveness, five types of amino acid (glycine, L-lysine, L-methionine, L-cysteine, and L-cystine) were used as the reactants. First, acetaldehyde-laden air was introduced into aqueous solutions of each amino acid and the removal abilities were compared. Among the five amino acids, L-cysteine solution showed much higher removal efficiency, while the other amino acids solutions didnt show any significant differences from the removal efficiency of water used as a control. Next, as a test of the removal abilities of acetaldehyde by semi-solid L-cysteine, a gel containing L-cysteine solution was put in a fluororesin bag filled with acetaldehyde gas, and the change of acetaldehyde concentration was measured. The L-cysteine-containing gel removed 80% of the acetaldehyde in the air within 24 hours. The removal ability likely depended on the unique reaction whereby acetaldehyde and L
Acetaldehyde is defined as an aldehyde, formed from acetic acid by the significant reduction of the carboxy group. Acetaldehyde is a chemical which acts as an intermediate in synthesizing other chemicals. Rising demand of acetaldehyde for diverse applications such as chemicals, food & beverage, paints & coatings, pharmaceuticals & cosmetics, and others is expected to proliferate the growth of the acetaldehyde market.. Get Sample PDF Copy: https://www.theinsightpartners.com/sample/TIPRE00004839/. The market for global acetaldehyde is concentrated with some very well-established players. Some of the key players in the global acetaldehyde market include Ashok Alco - chem Limited, Celanese Corporation, Chempure Private Limited, Eastman Chemical Company, Jubilant Life Sciences Limited, Lonza Group Ltd, LYC Chemical Corp, Merck KGaA, Sekab, and Sumitomo Chemical Co., Ltd. among others.. Based on application, the acetaldehyde market has been segmented into chemicals, plastics, and synthetic rubber, ...
Acetaldehyde is defined as an aldehyde, formed from acetic acid by the significant reduction of the carboxy group. Acetaldehyde is a chemical which acts as an intermediate in synthesizing other chemicals. Rising demand of acetaldehyde for diverse applications such as chemicals, food & beverage, paints & coatings, pharmaceuticals & cosmetics, and others is expected to proliferate the growth of the acetaldehyde market.. Get Sample PDF Copy: https://www.theinsightpartners.com/sample/TIPRE00004839/. The market for global acetaldehyde is concentrated with some very well-established players. Some of the key players in the global acetaldehyde market include Ashok Alco - chem Limited, Celanese Corporation, Chempure Private Limited, Eastman Chemical Company, Jubilant Life Sciences Limited, Lonza Group Ltd, LYC Chemical Corp, Merck KGaA, Sekab, and Sumitomo Chemical Co., Ltd. among others.. Based on application, the acetaldehyde market has been segmented into chemicals, plastics, and synthetic rubber, ...
Acetaldehyde is defined as an aldehyde, formed from acetic acid by the significant reduction of the carboxy group. Acetaldehyde is a chemical which acts as an intermediate in synthesizing other chemicals. Rising demand of acetaldehyde for diverse applications such as chemicals, food & beverage, paints & coatings, pharmaceuticals & cosmetics, and others is expected to proliferate the growth of the acetaldehyde market.. Get Sample PDF Copy: https://www.theinsightpartners.com/sample/TIPRE00004839/. The market for global acetaldehyde is concentrated with some very well-established players. Some of the key players in the global acetaldehyde market include Ashok Alco - chem Limited, Celanese Corporation, Chempure Private Limited, Eastman Chemical Company, Jubilant Life Sciences Limited, Lonza Group Ltd, LYC Chemical Corp, Merck KGaA, Sekab, and Sumitomo Chemical Co., Ltd. among others.. Based on application, the acetaldehyde market has been segmented into chemicals, plastics, and synthetic rubber, ...
Oral squamous cell carcinoma (OSCC) can remain undiagnosed until in an advanced, and sometimes lethal, state. It is often preceded by a potentially malignant lesion, which may manifest as a white patch leukoplakia of the oral mucosa. Previous research has implicated an association between the presence of Candida albicans and the progression of leukoplakias to OSCC. Alcohol may contribute to oral cancer via its conversion to acetaldehyde, a known carcinogen, which is also a product of C. albicans metabolism. The reversible conversion of ethanol to acetaldehyde is catalysed by enzymes known as alcohol dehydrogenases (ADHs) and in C. albicans, it is not known which ADH is responsible for acetaldehyde production. Aims of this study: To investigate expression of the CaADH genes in vitro and to identify the C. albicans genes responsible for acetaldehyde production. It is also the aim of this study to detect the expression of the CaADH genes in archival formalin-fixed paraffin-embedded (FFPE) samples ...
Learn about Acetaldehyde production processes: raw materials and utilities consumption, capital and operating costs, process flow diagrams. Free previews available
In this research, we reported a novel modified carbon ceramic electrode (CCE) using Ni/Al Layered double hydroxide as modifier was fabricated by sol-gel technique. The Ni/Al Layered double hydroxide modified sol gel derived carbon ceramic (Ni/Al LDH-SGD-CC) electrode was used for electrocatalytic oxidation of acetaldehyde. The oxidation of acetaldehyde happens at the potential where Ni (III) species are generated. The modified electrode exhibited remarkable electrocatalytic activity for the oxidation of acetaldehyde under alkaline conditions, indicating that the anodic oxidation of acetaldehyde could be catalyzed at Ni/Al LDH-SGD-CC electrode. This proves that the Ni/Al LDH bears the main role in electro-catalytic oxidation of acetaldehyde. Finally, by using the cyclic voltammetry, chronoamperometric and tafel plots method, the catalytic rate constant, charge-transfer coefficient, the number of electrons involved in the rate-determining step (nα) and exchange current density for chemical reaction of
TY - JOUR. T1 - Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats. AU - Cao, Junran. AU - Belluzzi, James D.. AU - Loughlin, Sandra E.. AU - Keyler, Daniel E.. AU - Pentel, Paul R.. AU - Leslie, Frances M.. N1 - Funding Information: We thank Yiling Chen, MD, and Ruihua Wang, MD for their assistance. This study is supported by DA 19138 and DA 21267.. PY - 2007/9. Y1 - 2007/9. N2 - We have previously shown that acetaldehyde, a constituent of tobacco smoke, increases nicotine self-administration in adolescent, but not adult, rats. The aim of this study was to determine whether acetaldehyde influences other behavioral, endocrine, or neuronal responses to nicotine at either age. Juvenile (postnatal day (P) 27) and adult (P90) male Sprague-Dawley rats were treated with saline, acetaldehyde (16 μg/kg/injection × 2, i.v.), nicotine (30 μg/kg/injection × 2, i.v.) or a combination of acetaldehyde and ...
The Global Acetaldehyde Market is forecast to reach USD 2.25 Billion by 2026, according to a new report by Reports and Data. Acetaldehyde, otherwise called ethanal (CH3CHO), is an organic compound in the aldehyde group. The colorless and flammable liquid has a pungent smell, and it is mainly used as vinegar in households. This compound is present in several fruits and vegetables as well as in diesel and gasoline exhausts. The market for acetaldehyde is influenced by the rising food & beverage and chemical industries. Besides the compound have various applications in paints and coatings, pharmaceuticals and cosmetics industries. The growing demand for basic dyes and polymer resins is expected to drive the growth of acetaldehyde market. Request a sample of this premium report at: https://www.reportsanddata.com/sample-enquiry-form/1889 The above-mentioned factors collectively create opportunities for the market growth while factors such as environmental and health hazards of acetaldehyde and ...
BioAssay Systems Acetaldehyde Assay Kit (EFAC-100) is based on aldehyde dehydrogenase catalyzed oxidation of acetaldehyde. Fluorescence intensity (530/585 nm) is proportional to acetaldehyde concentration. Samples: plasma, serum, urine, tissue/culture media, or food/beverage. Detection range: 0.5 - 60 µM.
Oxide-derived copper (OD-Cu) electrodes exhibit unprecedented CO reduction performance towards liquid fuels, producing ethanol and acetate with ,50 % Faradaic efficiency at -0.3 V (vs. RHE). By using static headspace-gas chromatography for liquid phase analysis, we identify acetaldehyde as a minor product and key intermediate in the electroreduction of CO to ethanol on OD-Cu electrodes. Acetaldehyde is produced with a Faradaic efficiency of ≈5 % at -0.33 V (vs. RHE). We show that acetaldehyde forms at low steady-state concentrations, and that free acetaldehyde is difficult to detect in alkaline solutions using NMR spectroscopy, requiring alternative methods for detection and quantification. Our results indicate an important step towards understanding the CO reduction mechanism on OD-Cu electrodes. ...
The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. An NBO study at these chemistry levels complemented these findings and assigned the eclipsed acetaldehyde preference mainly to the vicinal antiperiplanar hyperconjugative interactions. The tautomeric interconversion between the more stable eclipsed acetaldehyde and vinyl alcohol has been achieved through a four-membered ring transition state (TS). The obtained barrier heights and relative stabilities of eclipsed acetaldehyde and the two conformers of vinyl alchol at these model chemistries have been estimated and discussed.
TY - JOUR. T1 - Acetaldehyde self-administration by a two-bottle choice paradigm: Consequences on emotional reactivity, spatial learning, and memory. AU - Maniaci, Giuseppe. AU - De Caro, Viviana. AU - Giannola, Libero Italo. AU - Sutera, Flavia Maria. AU - Cannizzaro, Emanuele. AU - Cannizzaro, Carla. AU - Plescia, Fulvio. AU - Brancato, Anna. AU - Venniro, Marco. PY - 2015. Y1 - 2015. N2 - Acetaldehyde, the first alcohol metabolite, is responsible for many pharmacological effects that are not clearly distinguishable from those exerted by its parent compound. It alters motor performance, induces reinforced learning and motivated behavior, and produces different reactions according to the route of administration and the relative accumulation in the brain or in the periphery. The effective activity of oral acetaldehyde represents an unresolved field of inquiry that deserves further investigation. Thus, this study explores the acquisition and maintenance of acetaldehyde drinking behavior in adult ...
Abernethy DJ, Frazelle JH, Boreiko CJ [1982]. Effects of ethanol, acetaldehyde and acetic acid in the C3H/10T1/2 Cl 8 cell transformation system [Abstract Bf-1]. Environ Mutagen 4:331.. ACGIH [1986]. Industrial ventilation: a manual of recommended practice. 19th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.. American Cancer Society [1980]. Guidelines for the cancer-related check-up: recommendations and rationale. Cancer 30:4-50.. Ames BN, McCann J, Yamasaki E [1975]. Methods for detecting carcinogens and mutagens with the Salmonella /mammalian-microsome mutagenicity test. Mutat Res 31:347-363.. ANSI [1988]. American national standard fundamental governing the design and operation of local exhaust systems. New York, NY: American National Standards Institute, ANSI Z129.1-1988.. Asmussen E, Hald J, Larsen V [1948]. The pharmacological action of acetaldehyde on the human organism. Acta Pharmacol 4:311-320.. Auerbach C, Moutschen-Dahmen M Moutschen J [1977]. Genetic ...
Acetaldehyde dehydrogenase Acetaldehyde dehydrogenase Identifiers Symbol  ? Other data EC number 1.2.1.10 Acetaldehyde dehydrogenases (EC 1.2.1.10) are
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics. ...
Acetaldehyde is the first oxidation product of ethanol, and under normal conditions it is oxidized further so rapidly that significant acetaldehyde concentrations can only be found in the liver....
Good day, there. Eric Bakker, naturopath, author of Candida Crusher with another question.. Are my bad headaches caused from a yeast infection, Eric? I get lots of headaches. I get bloating.. Heres a question I do get asked not that often, but I do. And this is how Im going to explain it to you.. I think a key thing which people tend to overlook with Candida is what I call the metabolic byproducts of Candida. We know that Candida albicans is yeast, but what a lot of people dont know is what yeast can basically do; yeast can die down and cell wall fragments can create problems. Yeast can also create immunosuppressant toxins themselves, and yeast can also create another chemical called acetaldehyde, which is very common. Acetaldehyde also occurs when you drink alcohol. Acetaldehyde production also occurs when yeast are in the digestive system.. In Japan, high yeast in the gut is a disease now called Drunk Disease and some people can actually feel spaced out or stoned with high acetaldehyde ...
Buy Anticol Online! Anticol is used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. It acts by inhibiting aldehyde dehydrogenase. When alcohol is ingested after administration of Anticol, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome).
This paper uses a complicated set of phase-ins and phase-outs of oxygenated motor fuel in the Northeast to determine whether E-10 ethanol-enhanced fuel contributes to acetaldehyde air pollution over the pre-ethanol methyl tertiary-buthyl ether (MTBE) fuel. Oil companies phased out MTBE because of groundwater pollution concerns, and now E-10 is the standard fuel in EPA reformulated gas areas. Using a difference-in-difference setup, I find a small level increase but a large percentage increase in acetaldehyde pollution with E-10. I also compute a cost of the pollution in the single-digit millions of dollars. The findings concur with many scientific papers estimating that the impact of E-10 fuel on acetaldehyde pollution is small but positive. Steiner, Christopher
Short-term studies have been made on the effects of acetaldehyde on four different cell lines (clones). When the cells were exposed to relatively high concentrations of acetaldehyde, 2.0 and 8.0 mg/ml, they became fixed. Cells in 1.0 mg. and 0.5 mg. acetaldehyde per ml. did not become fixed but rounded up and detached within a few hours.. In 0.05 and 0.01 mg. acetaldehyde per ml. no definite effects were noted within the limits of the short-term testing, and hence these concentrations were used in the long-term studies. Mouse liver cells exposed to 0.05 mg. acetaldehyde per ml. for 23 days were all dead within 7 days following return to control medium. During the first 37 days in 0.01 mg/ml, the liver cells proliferated to a greater extent than those in control medium, but after this period the rate of increase was lower than in the controls.. Basically, the results obtained with Strain L cells and HeLa cells were similar to those with the mouse liver cells.. ...
Alcohol metabolism is dependent on two enzymes: alcohol dehydrogenase (ADH) that converts alcohol to acetaldehyde, and acetaldehyde dehydrogenase (ALDH) that further converts acetaldehyde to harmless products (like acetate).. About 80% of Asians have a hyper-functional alcohol dehydrogenase.3 That means Asians metabolize alcohol to acetaldehyde up to 100 times faster than others, but never really experience the buzz that normally comes with booze. Additionally, 40% have some sort of malfunction of acetaldehyde dehydrogenase (ALDH) that metabolizes further down the acetaldehyde. This is essentially a double whammy - they metabolize alcohol intake far too quickly into a toxic stage where it cant easily get out.. In practice, that glass of wine is converted to acetaldehyde too fast, and it just gets stuck inside of sufferers - then uncomfortable side effects ensue. Basically, their bodies arent fully equipped to break down alcohol in a safe and enjoyable way. Its safe to call this an alcohol ...
Resources of Acetaldehyde Elevated Acetaldehyde is located in end users of Alcoholic beverages, cigarettes, and consumers of carbohydrate abundant weight loss plans. Acetaldehyde is the primary metabolic breakdown merchandise of ethanol (alcohol). But Acetaldehyde is likewise generated throughout the human body, by yeasts as well as other anaerobic micro-organisms. These microbes bloom up and die off as blood sugar to start with spikes then falls immediately after taking in sweets and starches, most of that are aldehyde resources themselves. Some yeasts keep Acetaldehyde, releasing it when anti-yeast foods or medications are ingested. This acetaldehyde bomb is a large contributor towards the Herxheimer Reaction, a worsening of signs and symptoms when using helpful medication. Burning anything at all makes each Formaldehyde and Acetaldehyde. The principal human publicity to Acetaldehyde is vehicle exhaust, so ubiquitous that only one of the most remote areas are aldehyde free. Traditionally, ...
ChemicalBook provide Chemical industry users with 2-(1-NITRO-2-NAPHTHYL)ACETALDEHYDE O-METHYLOXIME(339100-56-0) Boiling point Melting point,2-(1-NITRO-2-NAPHTHYL)ACETALDEHYDE O-METHYLOXIME(339100-56-0) Density MSDS Formula Use,If You also need to 2-(1-NITRO-2-NAPHTHYL)ACETALDEHYDE O-METHYLOXIME(339100-56-0) Other information,welcome to contact us.
The report generally describes acetaldehyde, examines its uses, production methods, patents. Acetaldehyde market situation is overviewed; acetaldehyde
Yeast has been an important part of our portfolio ever since our predecessor company (Berkeley Yeast Laboratory) was founded in 1933. Our first commercial yeast offerings consisted of strains given to us from the collection of the University of California. The College of Agriculture at Berkeley had safeguarded them throughout the dark years of Prohibition. In each of the subsequent harvests we have learned and evolved. We are uniquely positioned to assist winemakers in meeting each years new challenges ...
When we humans consume alcohol, like most other drugs, it goes through certain metabolic processes. Interestingly, our liver produces an enzyme called alcohol dehydrogenase, which converts alcohol to acetaldehyde. Acetaldehyde, is further degraded by another enzyme acetaldehyde dehydrogenase. So let us see how is this acetaldehyde formation in body is important in various way: First…
A series of CuMgCeO{sub x} catalysts have been prepared. Range of Cu dispersion, determined by N{sub 2}O titration, was 19-48% and are among the highest reported in the literature for Cu-based methanol and higher alcohol synthesis catalysts. Kinetics of MeOH and EtOH coupling reactions on Cu/ZnO and K-Cu/MgO/CeO{sub 2} catalysts indicate that Cu promotes alcohol dehydrogenation. Acetaldehyde is a reactive intermediate. High-pressure isobutanol synthesis studies have been carried out on K- and Cs-promoted Cu/MgO/CeO{sub 2} catalysts. The K promoter is more active than Cs for CO conversion, but the Cs promoter activates the C{sub 1} to C{sub 2} step more effectively. Catalysts with high alkali loading resulted in low conversions. Temperature programmed surface reaction studies of MeOH, EtOH, and acetaldehyde on MgO/CeO{sub 2}-based Cu catalysts show evolution of acetone, crotonaldehyde, methyl ethyl ketone, H2, carbon oxides. Neither EtOH nor acetaldehyde produces propionaldehyde or 1- propanol,
TY - JOUR. T1 - Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde. AU - Duryee, Michael J.. AU - Klassen, Lynell Warren. AU - Jones, Bonnie L.. AU - Willis, Monte S.. AU - Tuma, Dean J.. AU - Thiele, Geoffrey Milton. PY - 2008/8/1. Y1 - 2008/8/1. N2 - Aldehyde modified proteins have been associated with the development and/or progression of alcoholic liver disease (ALD). These protein adducts are capable of initiating many immunological responses that are harmful to the normal homeostasis of organism function. Previous studies have shown that malondialdehyde (MDA) and acetaldehyde (AA) synergistically form a unique adduct (MAA) with soluble proteins, which are capable of inducing cytokine release, T-cell proliferation, and antibody production. The purpose of this study was to determine whether MAA adduction can elicit similar responses to cells using a well-defined tumor model. The mouse mastocytoma P815 tumor cell line was modified with MAA (P815-MAA) or left ...
Acetaldehyde (systematically ethanal) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated by chemists as MeCHO (Me = methyl). It is one of the most important aldehydes, occurring widely in nature and being produced on a large scale industrially. Acetaldehyde occurs naturally in coffee, bread, and ripe fruit, and is produced by plants as part of their normal metabolism. It is also produced by oxidation of ethylene and is popularly believed to be a cause of hangovers from alcohol consumption. Pathways of exposure include air, water, land or groundwater as well as drink and smoke. ...
http://www.acutemarketreports.com/category/chemicals-market. In a word, it was a depth research report on Global and China Acetaldoxime industry. And thanks to the support and assistance from Acetaldoxime industry chain related technical experts and marketing engineers during Research Team survey and interviews.. Latest Report by Acute Market Reports Global and China Acetaldehyde Market To 2015: Acute Market Reports. The report firstly introduced Acetaldehyde basic information included Acetaldehyde definition classification application industry chain structure industry overview; international market analysis, China domestic market analysis, Macroeconomic environment and economic situation analysis and influence, Acetaldehyde industry policy and plan, Acetaldehyde product specification, manufacturing process, product cost structure etc. then statistics Global and China key manufacturers Acetaldehyde capacity production cost price profit production value gross margin etc details information, at ...
The global acetaldehyde market is forecast to reach USD 2.25 billion by 2026, acetaldehyde is a natural compound; however, it can be produced commercially on a large scale by various chemical processes.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
An attempt is made to assess a set of biochemical, kinetic and anthropometric data for patients suffering from alcohol abuse (alcoholics) and healthy patients (non-alcoholics). The main goal is to identify the data set structure, finding groups of similarity among the clinical parameters or among the patients. Multivariate statistical methods (cluster analysis and principal components analysis) were used to assess the data collection. Several significant patterns of related parameters were found to be representative of the role of the liver function, kinetic and anthropometric indicators (conditionally named liver function factor, ethanol metabolism factor, body weight factor, and acetaldehyde metabolic factor). An effort is made to connect the role of kinetic parameters for acetaldehyde metabolism with biochemical, ethanol kinetic and anthropometric data in parallel ...
Acetaldehyde may be the culprit behind hangovers, according to new research from Japan. ... The problem many East Asians have in drinking alcohol is that their livers have a mutant form of the enzyme aldehyde dehydrogenase-2 (ALDH2), which in other people eliminates the acetaldehyde formed by ethanol metabolism, but often fails to do its job properly in East Asians, which means they suffer worse hangovers as this toxic compound stays in their system at higher concentrations than it would otherwise do so ...
Most Caucasians have two major isozymes, while approximately 50% of East Asians have one normal copy of the ALDH2 gene and one variant copy that encodes an inactive mitochondrial isoenzyme. In native Japanese, this variant ALDH2 gene encodes lysine instead of glutamic acid at amino acid 487 and therefore encodes a product protein that is completely inactive in metabolizing acetaldehyde to acetic acid.[13] In the overall Japanese population, about 57% of individuals are homozygous for the normal gene, 40% are heterozygous for the variant gene, and 3% are homozygous for the variant gene.[13] Since ALDH2 assembles and functions as a tetramer and requires all four of its components to be active in order to metabolize acetaldehyde, heterozygotes have very little ALDH2 activity.[14] Accordingly, individuals heterozygous or homozygous for the abnormal gene metabolize ethanol to acetaldehyde normally but metabolize acetaldehyde poorly and are thereby susceptible to certain adverse effects of alcoholic ...
In two recent papers from these laboratories it was shown that when methane- and ethane-oxygen mixtures containing excess of the hydrocarbon react at high pressure various liquid products can be isolated. For methane-oxygen mixtures methyl alcohol and water are found, and for ethane-oxygen mixtures ethyl alcohol, acetaldehyde, methyl alcohol, acetic acid, formic acid, and water. These products being important for the light they throw on the mechanism of hydrocarbon combustion and because they suggest means for using waste hydrocarbon gases, further experiments have now been made with the object of finding the order of their formation and the optimum condition for their survival. ...
In the first phase of the study, researchers looked at the role of the Aldh2 gene (which produces an enzyme for breaking down acetaldehyde) and how it affected the survival of foetal mice which had been genetically engineered to lack the Fancd2 gene that is involved in acetaldehyde sensitivity. The aim of this phase was to examine whether foetal mice could survive when lacking these two mechanisms for protecting against the toxic effects of acetaldehyde, as this compound is not just associated with alcohol but other processes as well.. They next looked at whether or not the toxic effects of acetaldehyde were enough, on their own, to cause foetal death or developmental defects. To do this, pregnant mice carrying foetuses lacking the Aldh2 gene and the Fancd2 gene were given a dose of alcohol, and the proportion of the surviving foetal mice that lacked these genes was determined. This was compared to pregnant control mice which were given a dose of saline instead of alcohol. The aim of this phase ...
Acetaldehyde, a toxic byproduct caused by the ingestion of alcohol, is an compound formed by an intermediate step in the conversion of sugar to ethanol by yeast. It is carcinogenic in rodents and causes sister chromatid exchanges and chromosomal aberrations in human cells. It is short lived, usually existing in the body only for a ...
To investigate this point further, we first established the impact of oxygen deprivation, and also of a return to air, on the dynamics of fermentation by monitoring oxygen and the production of ethanol, acetaldehyde and carbon dioxide ...
[145 Pages Report] Acetaldehyde Market Analysis categorizes the global market By Manufacturing Process (Acetylene Hydration, Others) Application (F&B, Pulp & Paper bleaching, Others) & geography
Alpha-[(dimethylamino)methylene]-1,3-benzodioxole-5-acetaldehyde/ACM53868352 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Abstract. Acetaldehyde is a reactive intermediate in hydrocarbon oxidation. It is both emitted and taken up by snowpacks and photochemical and physical processes are probably involved. Understanding the reactivity of acetaldehyde in snow and its processes of physical and chemical exchanges requires the knowledge of its incorporation mechanism in snow crystals. We have performed a season-long study of the evolution of acetaldehyde concentrations in the subarctic snowpack near Fairbanks (65° N), central Alaska, which is subjected to a vigorous metamorphism due to persistent elevated temperature gradients in the snowpack, between 20 and 200° C m−1. The snowpack therefore almost entirely transforms into depth hoar. We have also analyzed acetaldehyde in a manipulated snowpack where temperature gradients were suppressed. Snow crystals there transformed much more slowly and their original shapes remained recognizable for months. The specific surface area of snow layers in both types of snowpacks ...
Previous work on the acetaldehyde pyrolysis is shown to be vitiated by the presence, in the acetaldehyde, of impurities, mainly ethanol and crotonaldehyde. The reaction has been reinvestigated with the use of acetaldehyde, prepared from paraldehyde, which is free from these and other impurities. On the basis of a study of the kinetics of formation of the major products (methane and carbon monoxide) and of a number of minor products (hydrogen, acetone, propionaldehyde, ethane and ethylene) a reaction mechanism is proposed. This includes all of the reactions in the original Rice-Herzfeld scheme, together with a number of other elementary processes, in particular CH3 + CH3CHO → CH4 + CH2CHO. The decomposition of the radical CH2CHO into CH2CO and H provides an additional source of hydrogen, the rate of production of which is therefore not a measure of the rate of the initiation process. Acetone is believed to arise mainly by the reaction CH3 + CH3CHO → CH3COCH3 + H, and only to a negligible ...
Abstract: Oxidation of acetaldehyde molecules adsorbed on Na- and Mg-Wyoming montmorillonite at room temperature (20-25°C) and in N2 atmosphere has been studied by I.R. spectroscopy. A comparison between clay-acetic acid complex and that prepared from acetaldehyde is given. The influence of the nature of the saturating cation as well as the clay pretreatment on this oxidation process are discussed and reaction pathways are proposed. Acetic acid directly adsorbed on the clay surface is almost removed at 110°C, while that produced from the oxidation of the adsorbed acetaldehyde appears to be strongly held. Within a temperature range 180-230°C, the fixed acetic acid molecules dissociate to acetate form; then occurs an interaction of the acetate and the residual acid with the lattice OH of the clay at 200-300°C. This interaction involves the loss of the structural OH and deposition of carbon on the clay surfaces. The thermal decomposition1 of the residual complex is almost completed at ...
Medical information, Alcoholic cardiomyopathy. Definition of Alcoholic cardiomyopathy, symptoms of Alcoholic cardiomyopathy, treatment of Alcoholic cardiomyopathy, and prevention of Alcoholic cardiomyopathy. Exams and Tests Alcoholic cardiomyopathy.
Observations of the 1(01)-0(00) rotational transitions of A and E state acetaldehyde are reported. The transitions were detected, for the first time in interstellar space, in the cold dust clouds TMC-1 and L134N, and in Sgr B2. This is also the first time acetaldehyde has been found in a dust cloud and is the most complex oxygen-bearing molecule yet known in this environment. A column density of 6 x 10 to the 12th/sq cm in TMC-1, comparable to many other species detected there, and an approximately equal column density in L134N are formed. In the direction of Sgr B2, the CH3CHO profile appears to consist of broad emission features from the hot molecular cloud core, together with absorption features resulting from intervening colder material. The possible detection of HC9N toward IRC + 10 deg 216 through its J = 33-32 transition is also reported. Implications for cold dust cloud chemistry and excitation are discussed.
Acetaldehyde oxime (CAS 107-29-9) Market Research Report 2017 aims at providing comprehensive data on acetaldehyde oxime market globally and regionally
Humans metabolize ethanol primarily through NAD+-dependent alcohol dehydrogenase (ADH) class I enzymes (i.e. ADH1A, ADH1B, and ADH1C) to acetaldehyde and then metabolize acetaldehyde primarily by NAD2-dependent aldehyde dehydrogenase 2 (ALDH2) to acetic acid.[27][28] Eastern Asians reportedly have a deficiency in acetaldehyde metabolism in a surprisingly high percentage (approaching 50%) of their populations. The issue has been most thoroughly investigated in native Japanese where persons with a single-nucleotide polymorphism (SNP) variant allele of the ALDH2 gene were found; the variant allele, encodes lysine (lys) instead of glutamic acid (glu) at amino acid 487; this renders the enzyme essentially inactive in metabolizing acetaldehyde to acetic acid.[29][30] The variant allele is variously termed glu487lys, ALDH2*2, and ALDH2*504lys. In the overall Japanese population, about 57% of individuals are homozygous for the normal allele (sometimes termed ALDH2*1), 40% are heterozygous for glu487lys, ...
Humans metabolize ethanol primarily through NAD+-dependent alcohol dehydrogenase (ADH) class I enzymes (i.e. ADH1A, ADH1B, and ADH1C) to acetaldehyde and then metabolize acetaldehyde primarily by NAD2-dependent aldehyde dehydrogenase 2 (ALDH2) to acetic acid.[26][27] Eastern Asians reportedly have a deficiency in acetaldehyde metabolism in a surprisingly high percentage (approaching 50%) of their populations. The issue has been most thoroughly investigated in native Japanese where persons with a single-nucleotide polymorphism (SNP) variant allele of the ALDH2 gene were found; the variant allele, encodes lysine (lys) instead of glutamic acid (glu) at amino acid 487; this renders the enzyme essentially inactive in metabolizing acetaldehyde to acetic acid.[28][29] The variant allele is variously termed glu487lys, ALDH2*2, and ALDH2*504lys. In the overall Japanese population, about 57% of individuals are homozygous for the normal allele (sometimes termed ALDH2*1), 40% are heterozygous for glu487lys, ...
TY - JOUR. T1 - Immune responses to acetaldehyde-protein adducts. T2 - Role in alcoholic liver disease. AU - Tuma, Dean J.. AU - Klassen, Lynell Warren. PY - 1992/12. Y1 - 1992/12. UR - http://www.scopus.com/inward/record.url?scp=0026460942&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026460942&partnerID=8YFLogxK. U2 - 10.1016/0016-5085(92)91458-G. DO - 10.1016/0016-5085(92)91458-G. M3 - Editorial. C2 - 1451988. AN - SCOPUS:0026460942. VL - 103. SP - 1969. EP - 1973. JO - Gastroenterology. JF - Gastroenterology. SN - 0016-5085. IS - 6. ER - ...
Well-dispersed PtSn/C and PtSnO2/C catalysts with anatomic ratio of Pt:Sn (3:1) were deposited onto carbon using a modified alcohol-reduction process for electrochemical oxidation of ethanol. These materials were characterized using energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). An electrochemical study in theethanol and acid medium showed that the PtSnO2/C catalyst had a better performance compared with the PtSn/C and Pt/C catalysts. The CV analysis indicated that the presence of SnO2 increased the sensitivity of the catalyst to oxidation of acetaldehyde because of its low onset potential for the electrooxidation of adsorbed ethanol and acetaldehyde compared to PtSn/C and Pt/C. Since the activation of C-C bond breaking results in the generation of higher current density (mass activity) at higher potentials, the PtSnO2/C catalyst has been found favourable for the overall oxidation of ethanol.
Biohit Oyj Stock Exchange Release June 11, 2014 at 5 p.m. local time (EEST) MEP Sirpa Pietikäinen asked the Commission, whether the Commission, in the light of research which stresses the carcinogenic nature of acetaldehyde, does intend to set a limit for acetaldehyde in food or alcoholic beverages?
also termed the hangover effect of drinking. In most cases, the fermentation of the foods and beverages we consume occurs outside of the body. syndrome is characterized by mental confusion, poor memory, poor neuromuscular This remains, however, speculative, since we did not investigate the underlying genetic events, e.g., the formation of certain DNA-base adducts or the inactivation or mutation of tumor suppressor genes or oncogenes. Also, depending on a persons genes, acetaldehyde can promote alcoholism. free radicals also form. The combined expression of the pairs 4/13, 5/14, and 6/16 has been described for squamous nonstratifying epithelia ( 40 - 42 ). Acetaldehyde is a small compound that occurs naturally in coffee, bread, and even fruit. molecule. parts of the body such as the brain.3 Research has also shown that AH can then fold or deform. Naphtol as-bi-phosphate (50 mg) (Sigma Chemical Co.), dissolved in 600 μL N , N -dimethylformamide (Merck), was then added. This was observed in nine ...
Quality 2-(4-Hydroxyphenyl)Acetaldehyde Raw Material Drug Cas 7339-87-9 Pale Yellow Liquid for sale - buy cheap 2-(4-Hydroxyphenyl)Acetaldehyde Raw Material Drug Cas 7339-87-9 Pale Yellow Liquid from Raw Material Drug manufacturers & Raw Material Drug supplier of China (107860283).
[150 Pages Report] Check for Discount on 2016 Global and Chinese Acetaldehyde (CAS 75-07-0) Industry Market Research Report report by Prof Research. The Global and Chinese Acetaldehyde Industry, 2011-2021 Market Research...
[150 Pages Report] Check for Discount on Global and Chinese (tert-Butyldimethylsiloxy)acetaldehyde (CAS 102191-92-4) Industry, 2016 Market Research Report report by Prof Research. The Global and Chinese (tert-Butyldimethylsiloxy)acetaldehyde Industry, 2011-2021...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 68797-73-9(ACETALDEHYDE,[2,6-BIS(TERT-BUTYL)-4-METHYLPHENOXY]-),please inquire us for 68797-73-9(ACETALDEHYDE,[2,6-BIS(TERT-BUTYL)-4-METHYLPHENOXY]-).
The sinusoidal hepatic stellate cells (HSC) are the major effectors during hepatic fibrogenesis and cirrhosis. During the early stages of hepatic injury associated with cirrhosis, the normally quiescent, vitamin A-storing HSC transform into actively proliferating, collagen-producing myofibroblast-like cells (34). Alcohol is one of the principal causes of cirrhosis. While the major clinical problem of alcohol-induced hepatic fibrogenesis has been the subject of numerous studies, the precise molecular mechanism(s) which leads to the increase in αI(I) collagen in HSC remains incompletely understood (2, 6, 24, 26, 35,36). It was demonstrated that acetaldehyde, but not ethanol, induced the increase in the αI(I) collagen gene expression (up to 2.5-fold) measured by Northern blots in cultured 3T3 fibroblasts (2). Further studies indicated that acetaldehyde increased the αI(I) collagen gene transcription in cultured HSC demonstrated by transcription run-on assays (4). These previous observations ...
Studies have shown that alcohol is easily the most frequently consumed toxic substance, but when its mistreated, it may cause a number of health issues, including alcoholic cardiomyopathy.. Precisely what is alcoholic cardiomyopathy? Well, its a type of cardiovascular disease occurring because of lengthy-term excessive drinking. Doctors have noted for a lengthy time that mistreating alcohol for any lengthy time period can weaken and thin the center muscles, which could change up the hearts capability to pump bloodstream. This inefficient pumping of bloodstream could affect all of your bodys vital functions and result in existence-threatening heart issues.. Alcoholic cardiomyopathy is typical in males between 35 and 50 however, make no mistake, it may also affect women. Individuals who are afflicted by alcoholic cardiomyopathy will often have a lengthy-term good reputation for heavy consuming. With regards to drinking, lengthy-term is understood to be five to fifteen years. Heavy consuming of ...
Phenylacetaldehyde, also known as alpha-tolualdehyde or 2-phenylethanal, belongs to the class of organic compounds known as phenylacetaldehydes. Phenylacetaldehydes are compounds containing a phenylacetaldehyde moiety, which consists of a phenyl group substituted at the second position by an acetalydehyde. Historically, before biotechnology approaches were developed, phenylacetaldehyde was also used to produce phenylalanine via the Strecker reaction as a step in the production of aspartame sweetener. Phenylacetaldehyde is a drug. Phenylacetaldehyde is an extremely weak basic (essentially neutral) compound (based on its pKa). Phenylacetaldehyde exists in all living species, ranging from bacteria to humans. Phenylacetaldehyde is a sweet, bitter, and clover tasting compound. Outside of the human body, phenylacetaldehyde is found, on average, in the highest concentration in a few different foods, such as corns, safflowers, and bilberries and in a lower concentration in . phenylacetaldehyde has also ...
0005] Salsolinol (SAL) has been postulated to mediate some of the addictive properties of alcohol. A number of studies have shown that primates self-administer SAL even in nanomolar concentrations when intracranially injected to certain brain region. Also acetaldehyde is self-administered when injected intracranially although much higher concentrations are needed. Studies have confirmed that SAL is released during suckling on lactating sheep. It is clear that SAL mediates reinforcing effects on a number of primate species. Studies have shown that controlled amounts of ethanol intake have only miniscule effect on brain SAL levels. Still it is clear that ethanol intake elevates dopamine and acetaldehyde concentrations inside brain and so the concentrations of starting materials for Pictet-Spengler reaction forming SAL are elevated. In this light it seems certain that alcoholics with higher ethanol intake and generally higher aldehyde dehydrogenase (ALDH) activity (see Alcohol Clin. Exp. Res. 2009 ...
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
TY - JOUR. T1 - The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. AU - Xiao, Qing. AU - Weiner, Henry. AU - Crabb, David W.. PY - 1996/11/1. Y1 - 1996/11/1. N2 - Deficiency in mitochondrial aldehyde dehydrogenase (ALDH2), a tetrameric enzyme, results from inheriting one or two ALDH2*2 alleles. This allele encodes a protein subunit with a lysine for glutamate substitution at position 487 and is dominant over the wild-type allele, ALDH2*1. The ALDH2*2-encoded subunit (ALDH2K) reduces the activity of ALDH2 enzyme in cell lines expressing the wild-type subunit (ALDH2E). In addition to this effect on the enzyme activity, we now report that ALDH2*2 heterozygotes had lower levels of ALDH2 immunoreactive protein in autopsy liver samples. The half-lives of ALDH2 protein in HeLa cell lines expressing ALDH2*1, ALDH2*2, or both were determined by the rate of loss of immunoreactive ...
Another name for Alcoholic Cardiomyopathy is Alcoholic Cardiomyopathy. There is no cure for alcoholic cardiomyopathy, but treatment can control symptoms ...
Aldehyde dehydrogenases in rat brain: subcellular distribution, properties and involvement in acetaldehyde and dopamine metabolism ...
The root cause is a genetic predisposition to acetaldehyde build-up that is most commonly observed in people of Asian decent, hence it being colloquially termed Asian flush despite it not being exclusive to Asians.. Acetaldehyde is a toxic by-product of alcohol metabolism that is usually broken down by enzymes in our body in order to stop it from accumulating and causing a toxic reaction - i.e. the various symptoms of Asian flush. All that is required is one of more specific gene variants to be present for acetaldehyde build-up to occur.. One gene variant, observable in approximately 50% of Asian people, is called the mitochondrial ALDH2 allele, which results in a deficient aldehyde dehydrogenase enzyme that works at about 10% of its usual capacity. This enzyme is normally responsible for preventing acetaldehyde build up by catalyzing its conversion into non-toxic acetic acid.. In addition to this, and contrary to common belief, a study confirmed that 80% of Asians and nearly all Japanese, ...
Use of acetaldehyde in the fermentative production of ethanol AIM: Considerably reduce growth-coupled formation of glycerol during alcoholic fermentation and concomitantly increase output of ethanol per
Epidemiological studies have shown an association between alcohol (ethanol) consumption and increased cancer risk. The effect of alcohol consumption on the levels and persistence of N(2)-ethylidene-2-deoxyguanosine (N(2)-ethylidene-dG) formed by acetaldehyde, the oxidative metabolite of ethanol, in human leukocyte DNA was investigated. DNA was isolated from venous blood samples obtained from 30 male non-smoking individuals before consumption of alcohol (0h) and subsequently at 3-5h following the consumption of 150mL of vodka (containing 42% pure ethanol). Additional samples were collected 24h and 48h post-alcohol consumption. The levels of N(2)-ethyl-2-deoxyguanosine (N(2)-ethyl-dG) in the DNA were determined following reduction of N(2)-ethylidene-dG with sodium cyanoborohydride using a liquid chromatography-tandem mass spectrometry selected reaction monitoring method. A slight time-dependent trend showing an increase and decrease in the levels of N(2)-ethyl-dG was observed following ...
2. Several Others.. The presence of methyl alcohol in rum has been affirmed by researchers and denied by others no less trained. The acetal is assumed to be formed during barrel aging by the reaction of acetaldehyde and ethanol, which condense to form the acetal. The presence of aldehydes and acetals in rum predisposes it to the formation of new bodies of condensation of complex molecules, and that undoubtedly affect the final aroma of commercial rum.. [Acetaldehyde and acetal form an equilibrium where each is about 50/50. I have distilled wines full of acetaldehyde and watched them transform dramatically over months as acetal is formed. Excessive acetaldehyde in an unsound ferment may be best recycled to a ferment where it can be oxidized by yeast back to ethanol.]. Some of the components of the Non-Alcohol Coefficient have lower boiling points than ethyl alcohol. They also usually have very intense and irritating odors to the nasal mucosa, whose odors usually lack true aroma. Among these ...
It has recently been proposed that acetaldehyde is the physiological inducer of the alc gene system and hence indirectly the activator of the AlcA promoter in Aspergillus nidulans. Here we show that t...
It is concluded that oxaloacetate, required for the incorporation of ethanol into citrate, arises mainly from the transamination of aspartate and the fixation of carbon dioxide. 1. The pathway of ethanol metabolism in cotyledons of 3-day-old pea seedlings has been examined by incubating tissue slices with [1-(14)C]ethanol and [2-(14)C]ethanol for periods up to 1hr. 2. Ethanol was rapidly incorporated into citrate and glutamate but relatively small amounts of (14)C were present in the evolved carbon dioxide even after 1hr. of ethanol metabolism. 3. Similar data were obtained from experiments in which [1,2-(14)C(2)]acetaldehyde and [(14)C]acetate were supplied. 4. The results are interpreted as indicating that ethanol is metabolized essentially via the reactions of the tricarboxylic acid cycle with a substantial drain of alpha-oxoglutarate to support the biosynthesis of glutamate. 5. It is concluded that oxaloacetate, required for the incorporation of ethanol into citrate, arises mainly from the
To determine the effects of fruit maturity, storage temperature, and controlled atmosphere (CA) on aroma volatiles, mature-green (MG) and tree-ripe (TR) `Tommy Atkins mangoes (Mangifera indica L.) were stored for 21 days in air or in CA (5% O2 plus 10% or 25% CO2). The MG fruit were stored at 12 °C and the TR fruit at either 8 or 12 °C. Homogenized mesocarp tissue from fruit that had ripened for 2 days in air at 20 °C after the 21-day storage period was used for aroma volatile analysis. The TR mangoes produced much higher levels of all aroma volatiles except hexanal than did MG fruit. Both MG and TR mangoes stored in 25% CO2 tended to have lower terpene (especially p-cymene) and hexanal concentrations than did those stored in 10% CO2 and air-stored fruit. Acetaldehyde and ethanol levels tended to be higher in TR mangoes from 25% CO2 than in those from 10% CO2 or air storage, especially at 8 °C. Inhibition of volatile production by 25% CO2 was greater in MG than in TR mangoes, and at 8 °C ...
Low O2 and high CO2 concentrations can be used effectively to slow respiration and retard decay, but anaerobic and C02-injurious conditions must be avoided. The objective of this research was to: 1) determine the effects of low O2 and very high-C02 on flavor quality and accumulation of fermentation products. Strawberries and blueberries were stored in 2% O2/0% CO2, 20% 02/50% CO2, 2% O2/50% CO2, and 20% 02/0% CO2 for 0, 2, 4, 6, and 8 days at 20C. A taste panel evaluated the berries at the end of each storage period and again after 2 days under ambient conditions. Ethanol was the primary fermentation product that accumulated in response to low O2 and high CO2 concentrations. However, acetaldehyde was produced preferentially in response to elevated C02 levels. The flavor quality of the strawberries and blueberries was only acceptable for 2 days for treatments containing 50% CO2. The most intense off-flavors were detected in the 2% 02/50% CO2 and 20% O2/50% CO2 samples. 50% CO2 was highly ...
The photocatalytic activity of two commercial titanium dioxide powders (Cristal Global, Millennium PC500 and Evonik, P25) is compared towards acetaldehyde degradation in the gas phase. In contrast to the extensive literature available, we found a higher activity for the PC500 than for the P25 coating. Here, we present a comprehensive characterization of the bulk and surface properties of both powders. Our comparison shows that the material properties that dominate the overall photocatalytic activity in gas phase differ from those required for the photodegradation of water-borne pollutants. ...
6.3 Taiwan Acetaldehyde Sales Volume and Market Share by Application. Continue….. Enquire About This Report: https://www.marketresearchhub.com/enquiry.php?type=enquiry&repid=1340344. About Market Research Hub. Market Research Hub (MRH) is a next-generation reseller of research reports and analysis. MRHs expansive collection of chemicals market research reports has been carefully curated to help key personnel and decision makers across industry verticals to clearly visualize their operating environment and take strategic steps.. MRH functions as an integrated platform for the following products and services: Objective and sound market forecasts, qualitative and quantitative analysis, incisive insight into defining industry trends, and market share estimates. Our reputation lies in delivering value and world-class capabilities to our clients.. Contact Us. 90 State Street ...
Acetaldehyde 5-140 ppm Gas Detector Tube - Sensidyne is the Leader in Air Sampling Pumps and Equipment, Gas Detection, and Sound and Vibration Measurement.
Acetaldehyde diisoamyl acetal | C12H26O2 | CID 83036 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
(8a-methyl-1,3,4,7,8,8a-hexahydro-4a(2H)-naphthalenyl)acetaldehyde - C13H20O, synthesis, structure, density, melting point, boiling point
Buy our human hepatocellular liver carcinoma cell line nuclear lysate, acetaldehyde treated. ab14661 has been validated in electrophoretic mobility shift…
Listing your company for Acetaldehyde dimethyl acetal, 90% allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo!, MSN etc ...
Manufacturer and Suppliers of Acetaldehyde dimethyl acetal CAS: 105-57-7 from Germany, China, United States of America and Japan on Exportpages
acetaldehyde answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
4. The high nicotine concentrations of some products increase exposure risks for non-users, particularly children.. Using e-cigarettes requires heating the liquid solution and under such conditions, chemical reactions will result to formation of new compounds. The vaping liquid originally contains no potentially harmful substances; however, the components glycerin and propylene glycol will convert to formaldehyde and acetaldehyde when heated. [3] Formaldehyde and acetaldehyde are carcinogens (substances that are capable of causing cancer). Another study carried out by the National Jewish Health confirms that e-cigarette vapor damages the cells from human airways which increases the risk of respiratory infections. [4]. A more harrowing article was published in the New England Journal of Medicine in 2015, wherein a correspondence from Jensen, et. al. revealed that e-cigarettes contained hidden formaldehyde content. [5]Formaldehyde is chemical that is popularly used in industrial processes that ...
Recent reports have implicated liver non-parenchymal cells in liver injury as they can secrete; pro-inflammatory cytokines, excessive matrix proteins during fibrosis, and have been shown to initiate local immune responses [1-3]. Of the non-parenchymal cells, sinusoidal liver endothelial cells (SLECs) have been suggested to be a major contributor to the inflammatory processes observed in alcoholic liver disease (ALD) [4]. This is because SLECs are involved in the recruitment of leukocytes into the liver following the activation of an immune response, such as that observed in alcoholic hepatitis [4]. This process involves the release of cytokines TNF-alpha and IL-1beta, which increases the expression of adhesion molecules on the surface of SLECs and the release of chemokines (MIP-2 or MCP-1), which recruit leukocytes into the liver from the circulation [5, 6]. These chemokines cause increased binding of leukocytes to the vessel walls and promote the trans-migration of these immune cells across the ...
How Antabuse Works: The body processes alcohol by initially breaking it down into what is referred to as acetaldehyde. This is then broken down by another enzyme which is produced by the liver known as aldehyde dehydrogenase. The consumption of alcohol while taking Antabuse leads to the accumulation of acetaldehyde in the blood. This is because Antabuse inhibits the action of the enzyme aldehyde dehydrogenase. High levels of acetaldehyde affect the heart and the blood vessels. This leads to flushing, an increase in the heartbeat as well as a decrease in the blood pressure. This will lead to some dizziness. The disulfiram reaction is the name given to the side effects that occur from the consumption of alcohol while using Buy Antabuse No Prescription. Among these side effects include nausea, you may start to experience some vomiting, you may start to develop shortness of breath, some headaches and/or palpitations. These undesirable side effects are believed to deter those who wish to drink from ...
How Antabuse Works: The body processes alcohol by initially breaking it down into what is referred to as acetaldehyde. This is then broken down by another enzyme which is produced by the liver known as aldehyde dehydrogenase. The consumption of alcohol while taking Antabuse leads to the accumulation of acetaldehyde in the blood. This is because Antabuse inhibits the action of the enzyme aldehyde dehydrogenase. High levels of acetaldehyde affect the heart and the blood vessels. This leads to flushing, an increase in the heartbeat as well as a decrease in the blood pressure. This will lead to some dizziness. The disulfiram reaction is the name given to the side effects that occur from the consumption of alcohol while using Buy Antabuse No Prescription. Among these side effects include nausea, you may start to experience some vomiting, you may start to develop shortness of breath, some headaches and/or palpitations. These undesirable side effects are believed to deter those who wish to drink from ...
Rates of exchange catalysed by alcohol dehydrogenase were determined in vivo in order to find rate-limiting steps in ethanol metabolism. Mixtures of [1,1-2H2]- and [2,2,2-2H3]ethanol were injected in rats with bile fistulas. The concentrations in bile of ethanols having different numbers of 2H atoms were determined by g.l.c.-m.s. after the addition of [2H6]ethanol as internal standard and formation of the 3,5-dinitrobenzoates. Extensive formation of [2H4]ethanol indicated that acetaldehyde formed from [2,2,2-2H3]ethanol was reduced to ethanol and that NADH used in this reduction was partly derived from oxidation of [1,1-2H2]ethanol. The rate of acetaldehyde reduction, the degree of labelling of bound NADH and the isotope effect on ethanol oxidation were calculated by fitting models to the found concentrations of ethanols labelled with 1-42H atoms. Control experiments with only [2,2,2-2H3]ethanol showed that there was no loss of the C-2 hydrogens by exchange. The isotope effect on ethanol ...
Altomare E, Grattagliano I, Didanna D, et al. Gastric and intestinal ethanol toxicity in the rat. Effect on glutathione level and role of alcohol and acetaldehyde metabolisms. Ital. J. Gastroenterol Hepatol. 30:82-90. 1998 Medline. Aruzagaga S, Kavitha K, Nagini S. Erythrocyte lipid peroxidation and antioxidants in gastric cancer patients. Cell. Biochem. Funct. 15:15-18, 1997 Medline. Balint GA. A novel approach to reduce the unwanted gastric side-effects of orally administered non-steroidal anti-inflammatory drugs in rats. Exp. Toxicol. Pathol. 49:61-63, 1997 Medline. Davydenko OM, Kolomoiets MIU, Davydenko IS. Free-radical oxidation, the glutathione system and the status of the gastric mucosa in peptic ulcer in adolescents and young people under dynamic restoration treatment. Lik Sprava 7-8:60-64, 1994 Medline. Eapen CE, Madesh M, Balasubramanian KA, et al. Mucosal mitochondrial function and antioxidant defenses in patients with gastric carcinoma. Scand. J. Gastroenterol. 33:957-981, 1998 ...
... includes ... acetaldehyde; antimony compounds; arsenic; benzene; beryllium compounds; bis(2-ethylhexyl)phthalate ...
The Tishchenko reaction of acetaldehyde gives the commercially important solvent ethyl acetate. The reaction is catalyzed by ... Eckert, Marc; Fleischmann, Gerald; Jira, Reinhard; Bolt, Hermann M.; Golka, Klaus (15 December 2006). "Acetaldehyde". Ullmann's ...
Acetaldehyde - water vapor mixture is preconcentrated to 60-90% acetaldehyde by utilizing the heat of reaction and the ... crotonaldehyde or chlorinated acetaldehydes, are withdrawn together with acetaldehyde at the bottom. Due to the corrosive ... Acetaldehyde from Ethylene - A Retrospective on the Discovery of the Wacker Process Reinhard Jira Angew. Chem. Int. Ed. 2009, ... Catalyst solution containing acetaldehyde is separated by flash distillation. The catalyst is oxidized in the oxidation reactor ...
... can be prepared by combining pure acetaldehyde and hydroxylamine under heating in the presence of a base. The use ...
ΔGf = Σ ΔGfp − ΔGfo C2H6O(ethanol) + NAD+ → C2H4O(acetaldehyde) + NADH + H+ Ethanol: −174.8 kJ/mol Acetaldehyde: −127.6 kJ/mol ... The resulting backup of acetate shifts the reaction equilibrium for acetaldehyde dehydrogenase back towards acetaldehyde. ... acetaldehyde) + NAD+ + H2O → C2H4O2(acetic acid) + NADH + H+ Acetaldehyde: −127.6 kJ/mol Acetic acid: −389.9 kJ/mol ΔGf2 = − ... Acetaldehyde is a highly unstable compound and quickly forms free radical structures which are highly toxic if not quenched by ...
"Data sheet of acetaldehyde" (PDF). Merck. Retrieved 2014-06-02. Lide, David R., ed. (2009). CRC Handbook of Chemistry and ... 1,1-Diethoxyethane (acetaldehyde diethyl acetal) is a major flavoring component of distilled beverages, especially malt whisky ... In sensory terms, 1,1-diethoxyethane and other acetals, acetoin, and sotolon are the main compounds formed from acetaldehyde in ... ISBN 978-0-8247-8390-7. Zea, Luis; Serratosa, María P.; Mérida, Julieta; Moyano, Lourdes (2015). "Acetaldehyde as Key Compound ...
Patent 4,617,419 Process for preparing natural benzaldehyde and acetaldehyde, natural benzaldehyde and acetaldehyde ... This reaction also yields acetaldehyde. The natural status of benzaldehyde obtained in this way is controversial.Some other ...
It is the cyanohydrin of acetaldehyde. It is a colorless liquid, although degraded samples can appear yellow. Lactonitrile is ... obtained by the addition of hydrogen cyanide to acetaldehyde. Lactonitrile is used in making esters of lactic acid. ...
KING TE, CHELDELIN VH (1956). "Oxidation of acetaldehyde by Acetobacter suboxydans". J. Biol. Chem. 220 (1): 177-91. PMID ...
If the acetaldehyde is not metabolized quickly the nerves may be affected by the accumulation of acetaldehyde to toxic levels. ... Acetaldehyde is toxic to peripheral nerves. There are increased levels of acetaldehyde produced during ethanol metabolism. ... During the body's processing of alcohol, ethanol is oxidized to acetaldehyde mainly by alcohol dehydrogenase; acetaldehyde is ... For example, in the process of breaking down alcohol, the body produces acetaldehyde, which can accumulate to toxic levels in ...
Acetaldehyde. Acetaldehyde is a colorless, volatile substance with a fruity smell. Although it forms naturally in some fruit, ... and long barrel residence times all contribute to the production of acetaldehyde. When acetaldehyde is produced, some of it ... Special feature are: Acetaldehyde and oligomers are contained in the pellets at lower level; the viscosity is reduced somehow, ... Acetaldehyde forms by degradation of PET through the mishandling of the material. High temperatures (PET decomposes above 300 ° ...
There is also a formation of harmane (an MAO inhibitor) from the acetaldehyde in tobacco smoke. This may play a role in ... Talhout, R.; Opperhuizen, A.; Van Amsterdam, J. G. C. (October 2007). "Role of acetaldehyde in tobacco smoke addiction". ... acetaldehyde, ethylene oxide, and isoprene. Cigarette smoking has also been associated with sarcopenia, the age-related loss of ... Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells". J. Am. Chem. Soc. 133 (24): 9140 ...
It is the cyclic tetramer of acetaldehyde. Metaldehyde is obtained in moderate yields by treatment of acetaldehyde with various ... Metaldehyde has a toxicity profile identical to that for acetaldehyde, being mildly toxic and a respiratory irritant at the 50 ... The reaction is reversible; upon heating to about 80 °C, metaldehyde reverts to acetaldehyde. Metaldehyde exists as a mixture ... Methiocarb Paraldehyde Marc Eckert, Gerald Fleischmann, Reinhard Jira, Hermann M. Bolt, Klaus Golka "Acetaldehyde" in Ullmann's ...
In addition, about half of all East Asians convert acetaldehyde to acetic acid more slowly (via acetaldehyde dehydrogenase), ... causing a higher buildup of acetaldehyde than normally seen in other groups. The high concentration of acetaldehyde causes the ... Acetaldehyde, the first by-product of ethanol, is between 10 and 30 times more toxic than alcohol itself and can remain at an ... Cigarette smoking: acetaldehyde which is absorbed from cigarette smoking during alcohol consumption is regarded as a ...
Talhout, R; Opperhuizen, A; van Amsterdam, JG (Oct 2007). "Role of acetaldehyde in tobacco smoke addiction". Eur ... have been shown to be the primary precursors of acetaldehyde in tobacco smoke. The main polyphenols contained in the tobacco ...
Högberg, A. G. S. (1980). "Two stereoisomeric macrocyclic resorcinol-acetaldehyde condensation products". Journal of Organic ...
Acetaldehyde production is also associated with the presence of surface film forming yeasts and bacteria, such as acetic acid ... Acetaldehyde intoxication is also implicated in hangovers. Acetic acid in wine, often referred to as volatile acidity (VA) or ... Acetaldehyde is an intermediate product of yeast fermentation; however, it is more commonly associated with ethanol oxidation ... The sensory threshold for acetaldehyde is 100-125 mg/L. Beyond this level it imparts a sherry type character to the wine which ...
Högberg AGS (1980). "Two stereoisomeric macrocyclic resorcinol-acetaldehyde condensation products". Journal of Organic ...
Talhouth, Reinskje; Opperhuizen, Antoon; van Amsterdam G. C., Jan (October 2007). "Role of acetaldehyde in tobacco smoke ... and acetaldehyde one of the tobacco constituent decreased the expression of monoamine oxidase in the brain. Nicotine is ...
... acetaldehyde, and ammonia. In 1957, Zilkha reported a new simpler method based on adding amines to crotonic acid and then ...
It counteracts the poisonous effects of acetaldehyde. Cysteine supports the next step in metabolism, which turns acetaldehyde ... In a rat study, test animals received an LD90 dose of acetaldehyde. Those that received cysteine had an 80% survival rate; when ... "Protection against acetaldehyde toxicity in the rat by L-cysteine, thiamin and L-2-methylthiazolidine-4-carboxylic acid". ...
The hydration reaction of acetylene gives acetaldehyde. The reaction proceeds by formation of vinyl alcohol, which undergoes ...
... a molecule of acetaldehyde is released. In some bacteria, acetoin can also be reduced to 2,3-butanediol by acetoin reductase/2, ...
Role of acetaldehyde/xanthine oxidase-generated superoxide". Biochemical Journal. 257 (1): 277-280. doi:10.1042/bj2570277. ISSN ...
AcetaldehydeEdit. Acetaldehyde is produced by the liver as it breaks down ethanol. The liver then normally eliminates 99% of ... production of acetaldehyde, which is a weak mutagen and carcinogen. *induction of cytochrome P450 2E1 and associated oxidative ... A study of 818 heavy drinkers found that those who are exposed to more acetaldehyde than normal through a defect in the gene ... For example, it takes 12 hours to eliminate the ethanol in a bottle of wine, giving 12 hours or more of acetaldehyde exposure. ...
AcetaldehydeEdit. Acetaldehyde is an intermediate product of yeast fermentation; however, it is more commonly associated with ... Acetaldehyde intoxication is also implicated in hangovers. Acetic acidEdit. Acetic acid in wine, often referred to as volatile ... The sensory threshold for acetaldehyde is 100-125 mg/L. Beyond this level it imparts a sherry type character to the wine which ... Acetaldehyde. Smell of roasted nuts or dried out straw. Often described as green apples and emulsion paint. Commonly associated ...
... to acetaldehyde and then metabolize acetaldehyde primarily by NAD2-dependent aldehyde dehydrogenase 2 (ALDH2) to acetic acid. ... heterozygous for glu487lys metabolize ethanol to acetaldehyde normally but metabolize acetaldehyde poorly and are susceptible ... Presence of these alleles causes rapid conversion of alcohol to acetaldehyde which can be toxic in large amount. So, the East ... For Caucasians, ADH1B*1 allele is the most prevalent allele which causes slower conversion of alcohol to acetaldehyde and it ...
Macleod, Donald Bannerman (1910). "Rate of oxidation of acetaldehyde to acetic acid". Transactions of the New Zealand Institute ...
... is the cyclic trimer of acetaldehyde molecules. Formally, it is a derivative of 1,3,5-trioxane, with a methyl group ... Fehling, H. (1838) "Ueber zwei dem Aldehyd isomere Verbindungen" (On two compounds that are isomeric to acetaldehyde), Annalen ... Heated with catalytic amounts of acid, it depolymerizes back to acetaldehyde: C6H12O3 → 3CH3CHO Since paraldehyde has better ... On some products of the reaction of alkalies and acids with acetaldehyde), Annalen der Chemie, 66 : 152-165; see pp. 155-158. ...
... and acetaldehyde and 1,4-dioxane, both carcinogens. A plug-in air freshener contained more than 20 different volatile organic ...
Acetaldehyde dehydrogenase. (acetylating). Crystallographic structure of the acetaldehyde dehydrogenase from Pseudomonas sp.[1] ... The oxidation of acetaldehyde to acetate can be summarized as follows: Acetaldehyde + NAD+ + Coenzyme A ↔ Acetyl-CoA + NADH + H ... Acetaldehyde dehydrogenases (EC 1.2.1.10) are dehydrogenase enzymes which catalyze the conversion of acetaldehyde into acetic ... by acetaldehyde dehydrogenase. Acetaldehyde is more toxic than alcohol and is responsible for many hangover symptoms.[5] ...
"Acetaldehyde". Sigma-Aldrich Co., Acetaldehyde. Retrieved on 2013-07-20. "Acetaldehyde". NIOSH. 4 December 2014. Retrieved 12 ... Acetaldehyde is "one of the most frequently found air toxins with cancer risk greater than one in a million". Acetaldehyde was ... Acetaldehyde naturally breaks down in the human body but has been shown to excrete in urine of rats. Acetaldehyde is an ... Acetaldehyde is also present in automobile and diesel exhaust. As a result, acetaldehyde is "one of the most frequently found ...
acetaldehyde (ăs´Ĭtăl´dəhīd) or ethanal (ĕth´ənăl´), CH3CHO, colorless liquid aldehyde [1], sometimes simply called aldehyde. ... It is formed by the partial oxidation of ethanol; oxidation of acetaldehyde forms acetic acid. Acetaldehyde is made ... acetaldehyde (ăs´Ĭtăl´dəhīd) or ethanal (ĕth´ənăl´), CH3CHO, colorless liquid aldehyde, sometimes simply called aldehyde. It ... acetaldehyde World Encyclopedia © World Encyclopedia 2005, originally published by Oxford University Press 2005. ...
Acetaldehyde. CAS No: 75-07-0. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Acetaldehyde. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
In the second step, the acetaldehyde is converted to acetic acid by acetaldehyde dehydrogenase. Acetaldehyde is more toxic than ... The oxidation of acetaldehyde to acetate can be summarized as follows: Acetaldehyde + NAD+ + Coenzyme A ↔ Acetyl-CoA + NADH + ... Acetaldehyde dehydrogenases (EC 1.2.1.10) are dehydrogenase enzymes which catalyze the conversion of acetaldehyde into acetic ... In these people, acetaldehyde accumulates after drinking alcohol, leading to symptoms of acetaldehyde poisoning, including the ...
Holmes, J.L.; Lossing, F.P., Heats of formation of the ionic and neutral enols of acetaldehyde and acetone, J. Am. Chem. Soc., ... Jochims, H.-W.; Lohr, W.; Baumgartel, H., Photoionization mass spectrometry studies of deuterated acetaldehydes CH3CDO and CD3 ... Shigorin, D.N.; Filyugina, A.D.; Potapov, V.K., Ionization and dissociation of molecules of acetaldehyde, acetone, and acetic ... Walsh, A.D., The absorption spectrum of acetaldehyde in the vacuum ultra-violet, Proc. Roy. Soc. (London), 1946, A185, 176. [ ...
Acetic aldehyde, Ethanal, Ethyl aldehyde Colorless liquid or gas (above 69°F) with a pungent, fruity odor.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
acetaldehyde dehydrogenase [Desulfovibrio alaskensis G20]. * Record removed. The sequence YP_389768 is 100% identical to WP_ ...
Used in manufacture of paraldehyde, acetic acid, butanol, perfumes, flavors, aniline dyes, plastics, synthetic rubber, silvering mirrors, hardening gelatin fibers (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.. ...
The data comes from registration dossiers submitted to ECHA by the date indicated as last update. The Total Tonnage Band is compiled from all the dossiers with two exceptions; any tonnages claimed confidential and any quantity used as an intermediate to produce a different chemical. The Total Tonnage band published does not necessarily reflect the registered tonnage band(s).. Please note that some of the information on registered substances may belong to third parties. The use of such information may therefore require the prior permission of the third party owners. Please consult the Legal Notice for further information.. ...
Home Dictionary Acetaldehyde. Acetaldehyde. Acetaldehyde. Rarely an intended component of a beers profile, acetaldehyde is an ...
Acetaldehyde. Regulatory process names 23 Translated names 27 IUPAC names 2 Other identifiers 3 ...
Looking for SPECTRUM Acetaldehyde,Reagent,ACS,100mL (39G077)? Graingers got your back. Price:$411.50. Easy ordering & ...
Other data EC number 1.2.1.10 Acetaldehyde dehydrogenases (EC 1.2.1.10) are ... Acetaldehyde dehydrogenases (EC 1.2.1.10) are dehydrogenase enzymes which convert acetaldehyde into acetic acid. ... In these people, acetaldehyde accumulates after drinking alcohol, leading to symptoms of acetaldehyde poisoning, including the ... The oxidation of acetaldehyde to acetate can be summarized as follows: CH3CHO + NAD+ + CoA → acetyl-CoA + NADH + H+ The CAS ...
... acetaldehyde , C9H9ClO2 , CID 184605 - structure, chemical names, physical and chemical properties, classification, patents, ...
This page contains information on the chemical Acetaldehyde ammonia including: 4 synonyms/identifiers; U.S. Code of Federal ... Acetaldehyde ammonia. Identifications. *Synonyms/Related:*Acetaldehyde ammonia*Acetaldehyde ammonia trimer*Acetaldehyde ammonia ... Acetaldehyde ammonia (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Acetaldehyde ammonia ... Acetaldehyde ammonia. No. No. Related Resources. *USDOT Hazardous Materials Table 49 CFR 172.101. An online version of the ...
... acetaldehyde treated. ab14661 has been validated in electrophoretic mobility shift… ... Cells were cultured in medium supplemented with 200 µM Acetaldehyde for 4 hours at 37°C immediately prior to harvesting.. We ...
... This report analyzes the worldwide markets for Acetaldehyde in Tons. The Global market is further analyzed by the ... Acetaldehyde: A Vital Platform Chemical for Organic Chemicals Production Uses of Acetaldehyde Key Acetaldehyde Extraction ... Table 4: Permitted Acetaldehyde Concentration in Various Food and Beverages Categories 3. PRODUCT OVERVIEW Acetaldehyde: ... Acetaldehyde Usage in Butanediol Production Bode Well for the Market Major Challenges Hampering Acetaldehyde Consumption ...
Mesoporous Silica Oxidative dehydrogenation Ethanol Zirconia Acetaldehyde This work was presented at the 44th International ... Čičmanec P, Raabová K, Hidalgo J, Kubička D, Bulánek R (2017) Conversion of ethanol to acetaldehyde over VOX-SiO2 catalysts: ... Tesser R, Maradei V, Di Serio M, Santacesaria E (2004) Kinetics of the oxidative dehydrogenation of ethanol to acetaldehyde on ... VOx/Zr-SBA-15 catalysts for selective oxidation of ethanol to acetaldehyde. ...
The concentration of acetaldehyde in milk was always ca. 50% of that in blood, whereas that of ethanol varied within the range ... Alcohol and acetaldehyde were measured in milk and peripheral blood in chronic alcoholic rats, at 5 and 15 days of lactation. ... Acetaldehyde levels in milk were always 35-45% lower than in blood. No alcohol dehydrogenase activity was found in homogenates ... Alcohol and acetaldehyde in rats milk following ethanol administration.. Guerri C, Sanchis R. ...
Global Acetaldehyde Industry Report 2015 ​is a new market research publication announced by Reportstack. This report is a ... Chapter Seven Acetaldehyde Key Manufacturers Analysis. 7.1 Celanese. 7.1.1 Company Profile. 7.1.2 Product Picture and ... The Acetaldehyde industry development trends and marketing channels are analyzed. Finally the feasibility of new investment ... The Acetaldehyde market analysis is provided for the international markets including development trends, competitive landscape ...
... Acetaldehyde, butyl phenylethyl acetal Benzene, (2-(1-butoxyethoxy)ethyl)- EINECS 264-948-9 ... Acetaldehyde butyl phenethyl acetal
... triphenylphosphoranylidene acetaldehyde, 2-triphenyl-??-phosphanylidene acetaldehyde, acmc-209fjg, ksc492c5l. SMILES. C1=CC=C(C ... triphenylphosphoranylidene acetaldehyde, 2-triphenyl-??-phosphanylidene acetaldehyde, acmc-209fjg, ksc492c5l. IUPAC Name. 2-( ...
Acetaldehyde  Fouw, J. de; World Health Organization; International Programme on Chemical Safety (‎World Health ... Acetaldehyde : health and safety guide  World Health Organization; International Programme on Chemical Safety (‎World Health ...
Therefore, acetaldehyde cannot be synthesized by the CH3 + HCO coupling on the icy grains. We discuss the implications of these ... Formation of Acetaldehyde on Grain Surfaces. Complex Organic Molecules (COMs) have been detected in the interstellar medium ( ... As a test case of the COMs synthesis in the ISM, we present new quantum chemical calculations on the formation of acetaldehyde ... Formation of Acetaldehyde on Grain Surfaces. * Press Release - Source: astro-ph.EP ...
... acetaldehyde explanation free. What is acetaldehyde? Meaning of acetaldehyde medical term. What does acetaldehyde mean? ... Looking for online definition of acetaldehyde in the Medical Dictionary? ... acetaldehyde. Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia. acetaldehyde. [as″et-al´de-hīd] a ... It is postulated that the liver injury induced by ethanol is due to tissue responses to acetaldehyde, including acetaldehyde- ...
Acetaldehyde puriss. p.a., anhydrous, ≥99.5% (GC); CAS Number: 75-07-0; EC Number: 200-836-8; Synonyms: Ethanal; Linear Formula ... Acetaldehyde is an organic colorless flammable liquid. It can be produced by hydration of acetylene and by catalytic oxidation ... Acetaldehyde, the toxic product of ethanol metabolism in the liver, covalently binds to a variety of proteins, thereby altering ... Mechanism of the thermal decomposition of acetaldehyde has been reported. It is a product of ethanol metabolism in the liver, ...
Acetaldehyde is used in the production of drugs, perfumes, explosives, lacquers and varnishes, photographic chemicals, phenolic ... Chen, C. H.; Cruz, L.; Mochly-Rosen, D. Altering substrate specificity of aldehyde dehydrogenase 3A1 to enhance acetaldehyde ... to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. FASEB J. 2015, 112 (10), 3074-3079. ...
  • Consumption of disulfiram inhibits acetaldehyde dehydrogenase, the enzyme responsible for the metabolism of acetaldehyde, thereby causing it to build up in the body. (wikipedia.org)
  • Crystallographic structure of the acetaldehyde dehydrogenase from Pseudomonas sp . (wikipedia.org)
  • Acetaldehyde dehydrogenases ( EC 1.2.1.10 ) are dehydrogenase enzymes which catalyze the conversion of acetaldehyde into acetic acid . (wikipedia.org)
  • As discovered by site-directed mutagenesis , glutamate -268 is a key component of liver acetaldehyde dehydrogenase and is also critical to catalytic activity. (wikipedia.org)
  • In bacteria, acylating acetaldehyde dehydrogenase forms a bifunctional heterodimer with metal-dependent 4-hydroxy-2-ketovalerate aldolase . (wikipedia.org)
  • Utilized in the bacterial degradation of toxic aromatic compounds, the enzyme's crystal structure indicates that intermediates are shuttled directly between active sites through a hydrophobic intermediary channel, providing an unreactive environment in which to move the reactive acetaldehyde intermediate from the aldolase active site to the acetaldehyde dehydrogenase active site. (wikipedia.org)
  • In the liver , the enzyme alcohol dehydrogenase oxidizes ethanol into acetaldehyde , which is then further converted into the harmless acetic acid (vinegar) by acetaldehyde dehydrogenase. (wikipedia.org)
  • About 50% of people of Northeast Asian descent have a dominant mutation in their acetaldehyde dehydrogenase gene , [6] making this enzyme less effective. (wikipedia.org)
  • [7] Individuals with deficient acetaldehyde dehydrogenase activity are far less likely to become alcoholics , but seem to be at a greater risk of liver damage, alcohol-induced asthma, and contracting cancers of the oro-pharynx and esophagus due to acetaldehyde overexposure. (wikipedia.org)
  • In the first step, ethanol is converted to acetaldehyde by alcohol dehydrogenase. (wikipedia.org)
  • In the second step, the acetaldehyde is converted to acetic acid by acetaldehyde dehydrogenase. (wikipedia.org)
  • Acetaldehyde dehydrogenase s ( EC 1.2.1.10) are dehydrogenase enzymes which convert acetaldehyde into acetic acid. (bionity.com)
  • Some persons of far-Eastern descent have a dominant mutation in their acetaldehyde dehydrogenase gene (specifically, the mitochondrial ALDH2 gene), [1] making this enzyme less effective. (bionity.com)
  • It uses material from the Wikipedia article "Acetaldehyde_dehydrogenase" . (bionity.com)
  • In the human body, acetaldehyde is produced in the liver by the action of alcohol dehydrogenase and other enzymes. (thefreedictionary.com)
  • Mochly-Rosen, D. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH 2 in acetaldehyde and ethanol metabolism in vivo. (alfa.com)
  • Mochly-Rosen, D. Altering substrate specificity of aldehyde dehydrogenase 3A1 to enhance acetaldehyde metabolism, in vivo (585.9). (alfa.com)
  • Acetaldehyde is produced endogenously by alcohol metabolism and is catalyzed by aldehyde dehydrogenase 2 (ALDH2). (mdpi.com)
  • A product of alcohol metabolism that is more toxic than alcohol itself, acetaldehyde is created when the alcohol in the liver is broken down by an enzyme called alcohol dehydrogenase. (howstuffworks.com)
  • The acetaldehyde is then attacked by another enzyme, acetaldehyde dehydrogenase , and another substance called glutathione , which contains high quantities of cysteine (a substance that is attracted to acetaldehyde). (howstuffworks.com)
  • Together, the acetaldehyde dehydrogenase and the glutathione form the nontoxic acetate (a substance similar to vinegar). (howstuffworks.com)
  • In studies that blocked the enzyme that breaks down acetaldehyde (acetaldehyde dehydrogenase) with a drug called Antabuse , designed to fight alcoholism, acetaldehyde toxicity resulted in headaches and vomiting so bad that even alcoholics were wary of their next drink. (howstuffworks.com)
  • Although body weight is a factor (see How Alcohol Works ), part of the reason women should not keep up with men drink-for-drink is because women have less acetaldehyde dehydrogenase and glutathione, making their hangovers worse because it takes longer for the body to break down the alcohol. (howstuffworks.com)
  • Very recent epidemiologic studies on Asian heavy drinkers with impaired acetaldehyde metabolism due to aldehyde dehydrogenase-2 deficiency strongly suggest that acetaldehyde is a topical carcinogen in man ( 11 ). (aacrjournals.org)
  • In this study, we use transgenic overexpression of alcohol dehydrogenase to elevate cardiac exposure to acetaldehyde, the major and most reactive metabolite of alcohol. (aspetjournals.org)
  • The atypical genotypes of low K m aldehyde dehydrogenase (ALDH2) have higher blood concentrations of free acetaldehyde after drinking alcohol. (aacrjournals.org)
  • Acetaldehyde, a metabolic byproduct of ethanol in the liver, is toxic to the human body and is rapidly converted to the less harmful acetic acid by the enzyme aldehyde dehydrogenase. (bioassaysys.com)
  • People with a deficiency of aldehyde dehydrogenase accumulate acetaldehyde when consuming alcohol and this accumulation results in facial and body flushing often referred to as "Asian flush syndrome. (bioassaysys.com)
  • BioAssay Systems colorimetric acetaldehyde assay kit is based on aldehyde dehydrogenase catalyzed oxidation of acetaldehyde, in which the formed NADH reduces a formazan reagent. (bioassaysys.com)
  • The assay mechanism uses the enzyme aldehyde dehydrogenase to quantify acetaldehyde in the sample. (bioassaysys.com)
  • Ethanol in blood increased throughout lactation and the levels of acetaldehyde were much higher than in nonlactating alcoholic rats. (nih.gov)
  • If not, how will the Commission ensure that alcoholic beverages and food products offered for sale in the EU do not contain levels of acetaldehyde which are harmful to consumers? (globenewswire.com)
  • Many alcoholic beverages contain levels of acetaldehyde that exceed by a factor of more than 100 the limit which applies to cosmetics. (globenewswire.com)
  • Consequently, alcoholic beverages and food products which contain levels of acetaldehyde harmful to consumers shall not be placed on the market or, when already placed on the market, shall be withdrawn from the market. (globenewswire.com)
  • We measured levels of acetaldehyde reversibly bound to hemoglobin (HbAA) after drinking 0.4 ml/kg ethanol using fluorigenic high performance liquid chromatography method in volunteers with the two major ALDH2 genotypes. (aacrjournals.org)
  • [7] In these people, acetaldehyde accumulates after drinking alcohol, leading to symptoms of acetaldehyde poisoning, including the characteristic flushing of the skin and increased heart and respiration rates. (wikipedia.org)
  • Ethanal (common name acetaldehyde) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated by chemists as MeCHO (Me = methyl). (wikipedia.org)
  • acetaldehyde (ăs´Ĭtăl´dəhīd) or ethanal (ĕth´ənăl´) , CH 3 CHO, colorless liquid aldehyde , sometimes simply called aldehyde. (encyclopedia.com)
  • Based on these assumptions slow-release L-cysteine binds acetaldehyde to form inactive MTCA, which remains in gastric juice resulting in reduced local exposure of the gastric mucosa to carcinogenic acetaldehyde. (clinicaltrials.gov)
  • In this study, the efficacy of l -cysteine-containing tablets to reduce the carcinogenic acetaldehyde in the saliva during tobacco smoking was examined. (aacrjournals.org)
  • In conclusion, carcinogenic acetaldehyde could be totally inactivated in the saliva during smoking by sucking tablet containing 5 mg of l -cysteine. (aacrjournals.org)
  • According to laboratory analyses by Biohit and international research groups, a number of food products on the market contain abundantly carcinogenic acetaldehyde. (globenewswire.com)
  • This would increase the knowledge of acetaldehyde concentration and give the possibility for consumers to choose the products that have little or no carcinogenic acetaldehyde. (globenewswire.com)
  • The L-cysteine in Acetium capsules dissolves slowly into the gastric fluid, efficiently binding (neutralising) carcinogenic acetaldehyde in an achlorhydric stomach. (globenewswire.com)
  • The International Agency for Research on Cancer (IARC) has listed acetaldehyde as a Group 1 carcinogen. (wikipedia.org)
  • Based on extensive epidemiological evidence, the International Agency for Research on Cancer defined acetaldehyde associated with the consumption of alcoholic beverages as a "group 1 carcinogen" (definite carcinogen) for the esophagus and/or head and neck. (mdpi.com)
  • Microbes colonizing the acid-free stomach oxidize ethanol into acetaldehyde, a group 1 carcinogen. (clinicaltrials.gov)
  • Acetaldehyde has been shown to dissolve into the saliva during smoking and to be a local carcinogen in the human upper digestive tract. (aacrjournals.org)
  • Acetaldehyde is a known mutagen and carcinogen according to numerous in vitro cell culture studies and in vivo animal models ( 9 ). (aacrjournals.org)
  • The consistent epidemiological and biochemical results obtained from this model prompted the World Health Organization's International Agency for Research on Cancer (IARC) in October 2009 to classify the acetaldehyde found in, and generated endogenously from, alcoholic beverages as a Group I carcinogen, i.e. as carcinogenic as asbestos, formaldehyde and benzene. (globenewswire.com)
  • Acetaldehyde is suspected to be the ultimate carcinogen in alcoholrelated carcinogenesis. (aacrjournals.org)
  • Although classified as a carcinogen, acetaldehyde is naturally found in many foods and beverages such as ripe fruit, coffee, and wine. (bioassaysys.com)
  • ALDH2, which has a lower K M for acetaldehydes than ALDH1 and acts predominantly in the mitochondrial matrix, is the main enzyme in acetaldehyde metabolism and has three genotypes. (wikipedia.org)
  • ALDH2, which has a lower KM for acetaldehydes than ALDH1 and acts predominantly in the mitochondrial matrix, is the main enzyme in acetaldehyde metabolism and has three genotypes. (wikipedia.org)
  • Acetaldehyde, the toxic product of ethanol metabolism in the liver, covalently binds to a variety of proteins, thereby altering liver function and structure. (sigmaaldrich.com)
  • Acetaldehyde formed during ethanol metabolism has also been shown to be behind alcohol-related gastrointestinal tract carcinogenesis ( 10 ). (aacrjournals.org)
  • This deficiency results in the accumulation of acetaldehyde locally into the saliva during ethanol metabolism ( 12 ) and also in markedly increased risk for many upper gastrointestinal tract cancers ( 13 - 15 ). (aacrjournals.org)
  • Acetaldehyde (CAS 75-07-0) Market Research Report 2018 contents were worked out and placed on the website in January, 2018. (marketpublishers.com)
  • Please note that Acetaldehyde (CAS 75-07-0) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • This human "knock-out model" provides strong evidence for the topical carcinogenic role of acetaldehyde in the upper gastrointestinal tract in humans. (aacrjournals.org)
  • The aim is to assess gastric production of acetaldehyde and its inert condensation product, non-toxic 4-methyltiazolidine-2-carboxylic acid (MTCA), after alcohol intake under treatment with slow-release L-cysteine or placebo. (clinicaltrials.gov)
  • The production of acetaldehyde was monitored during the simulated atmospheric oxidation of ethyl-3-ethoxyproprionate (EEP), a paint component. (spie.org)
  • After intake, gastric concentrations of acetaldehyde, ethanol, L-cysteine and MTCA are analysed for 4 hours. (clinicaltrials.gov)
  • E. Majchrowicz and J.H. Mendelson , Blood Concentrations of Acetaldehyde and Ethanol in Chronic Alcoholics , Science 168 , 1100-1102 (1970). (springer.com)
  • When the cells were exposed to relatively high concentrations of acetaldehyde, 2.0 and 8.0 mg/ml, they became fixed. (aacrjournals.org)
  • The oxidation of acetaldehyde to acetate can be summarized as follows: Acetaldehyde + NAD+ + Coenzyme A ↔ Acetyl-CoA + NADH + H+ In humans, there are three known genes which encode this enzymatic activity, ALDH1A1, ALDH2, and the more recently discovered ALDH1B1 (also known as ALDH5). (wikipedia.org)
  • Fortunately the body has a range of detoxifying enzymes, aldehyde dehydrogenases, one of which, ALDH2, rapidly break down the acetaldehyde molecule. (thefreedictionary.com)
  • Alcohol consumption increases blood and salivary acetaldehyde levels, especially in individuals with ALDH2 polymorphisms, which are highly associated with the risk of squamous cell carcinomas in the upper aerodigestive tract. (mdpi.com)
  • As discussed in our article about ALDH2 deficiency, some individuals possess a mutated gene that causes a deficiency in their ability to break down acetaldehyde. (diobeth.org)
  • It was also used as calibration standard during determination of acetone, acetaldehyde, ethanol, and methanol in different human matrices, such as whole blood, vitreous humour, and urine using gas chromatography with flame ionization detection method (GC-FID). (sigmaaldrich.com)
  • GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture. (sigmaaldrich.com)
  • A.D. Horton and M.R. Guerin , Determination of Acetaldehydes and Acrolein in the Gas Phase of Cigarette Smoke Using Cryothermal Gas Chromatography , Tobacco 176 (4), 45-48 (1974). (springer.com)
  • Biohit Oyj Laboratory Services offer the determination of acetaldehyde concentration in food and alcohol beverages. (globenewswire.com)
  • Read more at http://www.biohithealthcare.com/laboratory-services/determination-of-acetaldehyde . (globenewswire.com)
  • Christensen JM, Angelo H, Knop J (1981) Determination of acetaldehyde in human blood by gas chromatographic method with negligible artefactual acetaldehyde formation. (springer.com)
  • Biohit's service laboratory offers alcohol and acetaldehyde concentrations determination services for nutrients in foods and alcoholic beverages. (globenewswire.com)
  • Determination of acetaldehyde-semicarbazone complex as the final product of the ADHa. (nih.gov)
  • The methods used for determining IgA antibody titres against protein acetaldehyde adducts have utilized immunoassays involving formation and detection/determination of the complex: anti-IgA -- sample IgA -- adduct Adduct stands for an in vitro prepared acetaldehyde adduct of a protein and it functions as an antigen in the assay. (google.com)
  • Acetaldehyde determination in biological and food/beverage samples. (bioassaysys.com)
  • Expected results show mitigated exposure of the gastric mucosa to acetaldehyde. (clinicaltrials.gov)
  • Acetaldehyde exposure: also serve to transport nutrients and biochemical raw materials manufactured into the active coenzyme form, NAD.17 Unfortunately for P5P (and we humans who Although studies do not show Acetaldehyde as being a factor in problems during "AH") into the human brain. (diobeth.org)
  • A diet high in refined sugars can lead to an increase in acetaldehyde exposure. (diobeth.org)
  • CEO Semi Korpela, Biohit Oyj: 'Almost all of the upper gastrointestinal tract cancer risk factors are associated with an increased exposure to acetaldehyde. (globenewswire.com)
  • www.gastropanel.com , www.acetium.com , www.acetium.com/test reveals your acetaldehyde exposure. (globenewswire.com)
  • In this study, we increased cardiac exposure to acetaldehyde by genetically increasing the activity of enzymes that produce it, specifically in the heart. (aspetjournals.org)
  • Exposure to acetaldehyde has been shown to be one of the most significant factors causing cancer in the upper gastrointestinal tract (mouth, the pharynx, the esophagus, the stomach). (globenewswire.com)
  • Biofood method invented by Biohit Oyj is intended to reduce the food stuff mediated exposure to acetaldehyde. (globenewswire.com)
  • Insufficient ability to remove acetaldehyde caused by point mutation provides a human model for acetaldehyde exposure, helping to explain the high incidence rates of upper gastrointestinal tract cancers in alcohol drinkers. (globenewswire.com)
  • Exposure to acetaldehyde is linked to more than three million new gastrointestinal cancers per year globally, which represents approximately 25 per cent of all cancers (visit www.acetium.com to test your exposure to acetaldehyde). (globenewswire.com)
  • The Acetium capsule is the only product in the world proven to reduce exposure to acetaldehyde. (globenewswire.com)
  • The HbAA levels are not only a good biomarker for increased internal exposure levels to acetaldehyde but may also be a predictive biomarker for acetaldehyde-mediated carcinogenesis. (aacrjournals.org)
  • Oxidative metabolites of alcohol, including acetaldehyde and acetate, induce cellular damage via several pathophysiological mechanisms. (thefreedictionary.com)
  • 11. A method for removing acetaldehyde from a mixture of methyl acetate, methanol and acetaldehyde comprising: (a) feeding a mixture of methyl acetate, methanol and acetaldehyde to a distillation column, wherein the feed mixture comprises at least about 5 wt. (freepatentsonline.com)
  • Most of the acetaldehyde formed from ethanol is subsequently oxidized to acetate in liver. (springer.com)
  • Thus, from 100% of product (25 mM), 97.3% of the oxidized ethanol is brought to acetate form and only 2% (0.5 mM) is released as acetaldehyde. (nih.gov)
  • Acetaldehyde is associated with the production of acetate, adduct formation, lipid peroxidation, and changes in the redox state of cells, all of which may play contributory roles in the development of hepatic fibrogenesis by an as yet incompletely understood mechanism ( 2 , 6 , 24 , 26 , 35 , 36 ). (asm.org)
  • The purpose of the report is to describe the state of the acetaldehyde market in the GCC countries, to present actual and retrospective information about the volumes, dynamics, structure and characteristics of production, imports, exports and consumption and to build a forecast for the market in the next five years. (reportsnreports.com)
  • Global Acetaldehyde Market segment by Regions, Acetaldehyde market report splits Global into several key Regions, with Acetaldehyde production, Acetaldehyde consumption, Acetaldehyde revenue, Acetaldehyde market share and growth rate of Acetaldehyde in these regions, from 2011 to 2021. (webnewswire.com)
  • Acetaldehyde Market report split by Product type and Application, with Acetaldehyde production, revenue, price, market share and growth rate of each type, according to Application Acetaldehyde Market report focuses on consumption, market share and growth rate of Acetaldehyde in each application. (webnewswire.com)
  • Build up of acetaldehyde has also been associated with the effects of hangovers from alcohol consumption. (bioassaysys.com)
  • Boldog I, Čičmanec P, Ganjkhanlou Y, Bulánek R (2017) Surfactant templated synthesis of porous VO x -ZrO 2 catalysts for ethanol conversion to acetaldehyde. (springer.com)
  • Čičmanec P, Raabová K, Hidalgo J, Kubička D, Bulánek R (2017) Conversion of ethanol to acetaldehyde over VOX-SiO2 catalysts: the effects of support texture and vanadium speciation. (springer.com)
  • 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/770113/all/acetaldehyde. (tabers.com)
  • Acetaldehyde oxime (CAS 107-29-9) Market Research Report 2017 aims at providing comprehensive data on acetaldehyde oxime market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • Acetaldehyde oxime (CAS 107-29-9) Market Research Report 2017 contents were prepared and placed on the website in November, 2017. (marketpublishers.com)
  • Global Acetaldehyde Market 2017, presents a professional and in-depth study on the current state of the Acetaldehyde market globally, providing basic overview of Acetaldehyde market including definitions, classifications, applications and industry chain structure, Acetaldehyde Market report provides development policies and plans are discussed as well as manufacturing processes and cost structures. (webnewswire.com)
  • Global market research report of Acetaldehyde 2017 mainly focuses on Production, means the output of Acetaldehyde and Revenue, means the sales value of Acetaldehyde in market. (webnewswire.com)
  • Acetaldehyde Market Research Report 2017 Covers the following Manufacturers. (webnewswire.com)
  • Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA, including DNA adducts, single- and/or double-strand breaks (DSBs), point mutations, sister chromatid exchanges (SCEs), and DNA-DNA cross-links. (mdpi.com)
  • Among these, DNA adducts such as N 2 -ethylidene-2′-deoxyguanosine, N 2 -ethyl-2′-deoxyguanosine, N 2 -propano-2′-deoxyguanosine, and N 2 -etheno-2′-deoxyguanosine are central to acetaldehyde-mediated DNA damage because they are associated with the induction of DNA mutations, DNA-DNA cross-links, DSBs, and SCEs. (mdpi.com)
  • In this article, we review recent advances from studies of acetaldehyde-mediated carcinogenesis in the squamous epithelium, focusing especially on acetaldehyde-mediated DNA adducts. (mdpi.com)
  • The present invention concerns an improved immunoassay method for the measurement of IgA antibodies directed against acetaldehyde adducts of proteins. (google.com)
  • Trimeric Acetaldehyde Report by Material, Application, and Geography - Global Forecast to 2022 is a professional and in-depth research report on the world's major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, united Kingdom, Japan, South Korea and China). (marketresearch.com)
  • Acetaldehyde market research report studies Acetaldehyde in Global market, Acetaldehyde market report gives detail analysis of regions especially in North America, Europe, China, Japan, Korea and Taiwan. (webnewswire.com)
  • Global Diethyl Acetaldehyde Market 2015 Size, Share, Growth, Trends, Demand and Forecast - 2015 Global Diethyl Acetaldehyde Industry Report is a professional and in-depth research report on the world's major regional market conditions of the Diethyl Acetaldehyde industry, focusing on the main regions (North America, Europe and Asia) and the main countries (United States, Germany, Japan and China). (powershow.com)
  • 2015 Global Diethyl Acetaldehyde Industry Report is a professional and in-depth research report on the world's major regional market conditions of the Diethyl Acetaldehyde industry, focusing on the main regions (North America, Europe and Asia) and the main countries (United States, Germany, Japan and China). (powershow.com)
  • Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species (ROS) level and apoptosis. (ovid.com)
  • Recently, the presence of antibodies reactive with acetaldehyde modified protein epitopes in the plasma of alcoholics has been linked to alcohol abuse. (google.com)
  • I have seen other sources that use dichromates to make acetaldehyde from acetone- so why do we have to declare that this is half-assed becuase it lists 8 synonyms for water? (sciencemadness.org)
  • Perhaps we can condense it along with acetone, convert it to the trimer, and reproduce te acetaldehyde? (sciencemadness.org)
  • Global Acetaldehyde Industry Report 2015 ​is a new market research publication announced by Reportstack. (pitchengine.com)
  • ReportsnReports.com adds report 2014 Market Research Report on Global Acetaldehyde Industry to its store. (pitchengine.com)
  • 2014 Market Research Report on Global Acetaldehyde Industry is a professional and depth research report on Global Acetaldehyde industry that you would know the world''s major regional market conditions of Acetaldehyde industry, the main region including North American, Europe and Asia etc, and the main country including United States ,Germany ,Japan and China etc. (pitchengine.com)
  • In the end, the report introduced Acetaldehyde new project SWOT analysis, investment feasibility analysis, and investment return analysis and Global Acetaldehyde industry. (pitchengine.com)
  • In a word, it was a depth research report on Global Acetaldehyde industry. (pitchengine.com)
  • Report' is a professional and in-depth study on the current state of the global Acetaldehyde industry with a focus on the Chinese market. (powershow.com)
  • Similarly noncompetitive, acetaldehyde arises from synthesis gas with modest selectivity. (wikipedia.org)
  • Acetaldehyde is a common electrophile in organic synthesis. (wikipedia.org)
  • Acetaldehyde may be used for the enzymatic synthesis of fatty acids. (sigmaaldrich.com)
  • The acetaldehyde-ammonia trimer is a molecule of interest in organic synthesis, since it can be used as a substrate in many reactions involving acetaldehyde or ammonia. (rsc.org)
  • Aldoximes, such as acetaldehyde oxime, are used as intermediates in chemical synthesis. (marketpublishers.com)
  • Cederbaum AI, Lieber CS, Rubin E (1974a) The effect of acetaldehyde on mitochondrial function. (springer.com)
  • Protection against acetaldehyde toxicity (i.e. anesthesia and lethality) was studied in rats by oral intubation of test compounds 30-45 minutes prior to oral intubation of a standardized oral LD 90 dose (18 millimoles/kologram) of acetaldehyde. (springer.com)
  • H. Sprince, C.M. Parker, G.G. Smith and L.J. Gonzales , Protection against Acetaldehyde Toxicity in the Rat by l -Cysteine, Thiamin, and l -2-Methylthiazolidine-4-Carboxylic Acid, Agents and Actions 4 , 125-130 (1974). (springer.com)
  • H. Sprince, C.M. Parker, G.G. Smith , and L.J. Gonzales , Protectants against Acetaldehyde Toxicity: Sulfhydryl Compounds and Ascorbic Acid , Fed. (springer.com)
  • H. Sprince, C.M. Parker, G.G. Smith and L.J. Gonzales , Protection against Acetaldehyde Toxicity and Lethality by l -Cysteine Plus Thiamin, Fed. (springer.com)
  • Cysteine can bind to acetaldehyde and eliminate its toxicity. (aacrjournals.org)
  • La'Teese Hall, Sarah J. Murrey, and Arthur S. Brecher, "Aromatic Amines Exert Contrasting Effects on the Anticoagulant Effect of Acetaldehyde upon APTT," Advances in Hematology , vol. 2014, Article ID 735751, 8 pages, 2014. (hindawi.com)
  • Metabolic effects of acetaldehyde. (sigmaaldrich.com)
  • Short-term studies have been made on the effects of acetaldehyde on four different cell lines (clones). (aacrjournals.org)
  • The focus of this study is on describing the course of reaction after addition of acetaldehyde to solutions of ammonia and various acids. (rsc.org)
  • Using a difference-in-difference setup, I find a small level increase but a large percentage increase in acetaldehyde pollution with E-10. (umn.edu)
  • The Commission answered that The Commission will raise the issue with the competent authorities of the Member States and, if appropriate, the European Food Safety Authority (EFSA) will be requested to assess the risk for human health related to the presence of acetaldehyde in food as process contaminant or as a natural flavour. (globenewswire.com)
  • The method is based on the reaction between piperazine and 2,3-dichloro-1, 4-naphthoquinone in presence of acetaldehyde to give a violet colored product having lmax at 580nm. (ijpsonline.com)
  • Alcohol and acetaldehyde in rat's milk following ethanol administration. (nih.gov)
  • Alcohol and acetaldehyde were measured in milk and peripheral blood in chronic alcoholic rats, at 5 and 15 days of lactation. (nih.gov)
  • Vinyl alcohol and acetaldehyde are isoelectronic products of incomplete butanol combustion. (rsc.org)
  • This information shows that an analysis of acetaldehyde must take all these different forms into account, as well as the rate of formation of the various products. (avf.org)
  • A) UV/vis spectra of the formation of acetaldehyde-semicarbazone complex at 223 nm. (nih.gov)
  • Two lines of research involving acetaldehyde are reviewed: (1) implications of the formation of acetaldehyde in brain areas such as the NArc, with high expression of ethanol metabolizing enzymes and presence of cell bodies of endorphinic neurons and (2) the formation of condensation products between DA and acetaldehyde such as salsolinol, which exerts its actions via OR. (frontiersin.org)
  • The concentration of acetaldehyde in milk was always ca. 50% of that in blood, whereas that of ethanol varied within the range of 44-80% of the blood levels. (nih.gov)
  • It is postulated that the liver injury induced by ethanol is due to tissue responses to acetaldehyde, including acetaldehyde-induced fibrogenesis, acetaldehyde-induced lipid peroxidation enzyme inhibition, and formation of antibodies against acetaldehyde adduct proteins-e.g., serum albumin, hemoglobin, and cytokskeletal proteins, including tubulin. (thefreedictionary.com)
  • This process typically is conducted over a silver catalyst at about 500-650 °C. CH3CH2OH + 1⁄2 O2 → CH3CHO + H2O This method is one of the oldest routes for the industrial preparation of acetaldehyde. (wikipedia.org)
  • This reaction is catalyzed by mercury(II) salts: C2H2 + Hg2+ + H2O → CH3CHO + Hg The mechanism involves the intermediacy of vinyl alcohol, which tautomerizes to acetaldehyde. (wikipedia.org)
  • Traditionally, acetaldehyde was produced by the partial dehydrogenation of ethanol: CH3CH2OH → CH3CHO + H2 In this endothermic process, ethanol vapor is passed at 260-290 °C over a copper-based catalyst. (wikipedia.org)
  • Dissociative electron attachment to acetaldehyde, CH3CHO. (open.ac.uk)
  • The reaction of the methylidyne radical (CH) with acetaldehyde (CH3CHO) is studied at room temperature and at a pressure of 4 Torr (533.3 Pa) using a multiplexed photoionization mass spectrometer coupled to the tunable vacuum ultraviolet synchrotron radiation of the Advanced Light Source at Lawrence Berkeley National Laboratory. (edu.au)
  • One potential toxin is the major metabolite of ethanol, acetaldehyde. (aspetjournals.org)
  • The present review summarizes accumulative data suggesting that the first metabolite of ethanol, the psychoactive compound acetaldehyde, could participate in such mechanism. (frontiersin.org)
  • Acetaldehyde, the primary metabolite of ethanol, has been shown to accumulate in the blood and liver following chronic ethanol intake (Nuutinen et al. (google.com)
  • An NBO study at these chemistry levels complemented these findings and assigned the eclipsed acetaldehyde preference mainly to the vicinal antiperiplanar hyperconjugative interactions. (mdpi.com)
  • http://www.erowid.org/archive/rhodium/chemistry/acetaldehyde. (sciencemadness.org)
  • The catalytic conversion of ethanol to acetaldehyde was much more efficient using Fe/Sb/SiO 2 than Fe/SiO 2 as catalyst. (scielo.br)
  • The dispersion of Fe(III) was compared for the two synthetic processes using the catalytic activity for the oxidation of alcohol to acetaldehyde. (scielo.br)
  • Acetaldehyde (ACD), the first oxidation product of ethanol, has been found to share many neurobehavioral effects with the drug. (frontiersin.org)
  • Acetaldehyde is the first oxidation product of ethanol, and under normal conditions it is oxidized further so rapidly that significant acetaldehyde concentrations can only be found in the liver. (springer.com)
  • We show that acetaldehyde forms at low steady-state concentrations, and that free acetaldehyde is difficult to detect in alkaline solutions using NMR spectroscopy, requiring alternative methods for detection and quantification. (osti.gov)
  • This report presents a strategic analysis of the acetaldehyde market in the GCC countries and a forecast for its development in the medium term. (reportsnreports.com)
  • Industry Size, Share & Growth Report 2025 - A new report available with decisiondatabases.com on Acetaldehyde Market which provides an in-depth analysis during the forecast period. (powershow.com)
  • The reaction is conducted at 90-95 °C, and the acetaldehyde formed is separated from water and mercury and cooled to 25-30 °C. In the wet oxidation process, iron(III) sulfate is used to reoxidize the mercury back to the mercury(II) salt. (wikipedia.org)
  • In a Strecker reaction, acetaldehyde condenses with cyanide and ammonia to give, after hydrolysis, the amino acid alanine. (wikipedia.org)
  • This change in distribution of reaction products is related to stronger acidity character of surface OH groups and inhibition effect of formed water vapours on the oxidative dehydrogenation products (acetaldehyde). (springer.com)
  • The pH dependency of the reaction of acetaldehyde and ammonia to form the acetaldehyde-ammonia trimer has been studied in detail. (rsc.org)
  • Based on our results, we propose some adjustments to the traditional reaction scheme developed for acetaldehyde-ammonia trimer formation at high pH. (rsc.org)
  • Moreover, the enzyme utilizes ethanol as a substrate in a reaction mechanism where this is subjected to a two-step oxidation process to produce acetic acid without releasing the acetaldehyde intermediary to the media. (nih.gov)
  • Product detection of the CH radical reaction with acetaldehyde" by Fabien Goulay, Adam J. Trevitt et al. (edu.au)
  • Analysis of the photoionization yields versus photon energy for the reaction of CH and CD radicals with acetaldehyde and CH radical with partially deuterated acetaldehyde (CD3CHO) provides fine details about the reaction mechanism. (edu.au)
  • The insertion of the CH radical into a C-H bond of the methyl group of acetaldehyde is likely to lead to a C3H5O reaction intermediate that can isomerize by β-hydrogen transfer of the aldehydic hydrogen atom and dissociate to form acrolein + H or ketene + CH3, which are observed directly. (edu.au)
  • Complex organic acids, such as e.g. maleic or nicotinic acid, lead to comparable quantities of the trimer and acetaldehyde. (rsc.org)
  • Acetaldehyde + CoA + NAD + = acetyl-CoA + NADH. (uniprot.org)
  • An immunoassay method for detecting acetaldehyde protein adduct specific IgA antibody in body fluid samples employing an acetaldehyde adduct as the antigen, characterized in that the adduct is between acetaldehyde and a fragment of a native protein. (google.com)
  • A test kit useful for the immunoassay and the diagnostic method comprising anti-IgA antibody and an acetaldehyde adduct with a fragment of a native polypeptide. (google.com)
  • The aldol condensation of acetaldehyde and heptanal in the presence of hydrotalcite-type catalysts has been described. (sigmaaldrich.com)
  • It is also produced by aldol condensation of benzaldehyde & acetaldehyde or from cinnamyl alcohol. (powershow.com)
  • The hydroformylation of methanol with catalysts like cobalt, nickel, or iron salts also produces acetaldehyde, although this process is of no industrial importance. (wikipedia.org)
  • This demonstrates that many of ethanol's toxic effects are mediated via the acetaldehyde metabolite and can therefore be mitigated by substances such as fomepizole which effectively reduces the conversion rate of ethanol to acetaldehyde in vivo . (wikipedia.org)
  • However, a lack of suitable methods for chronically altering acetaldehyde concentration in vivo has prevented a definitive test of the acetaldehyde hypothesis. (aspetjournals.org)
  • The importance of these experiments was that we now understand the fate of acetaldehyde as it is formed in wine during fermentation and later formed by oxidation. (avf.org)
  • Research indicates that Acetaldehyde is an intermediary compound in the fermentation of some apples on the way to ethanol. (gotmead.com)
  • Acetaldehyde is more toxic than alcohol and is responsible for many hangover symptoms. (wikipedia.org)
  • Acetaldehyde is a powerful poison, considerably more toxic than alcohol, and is capable of damaging almost any part of the body. (thefreedictionary.com)
  • Acetaldehyde is a toxic substance common to heavy drinking of alcohol and heavy smoking of cigarettes. (springer.com)
  • Moreover, we propose a mechanism that, under physiological conditions, might permit a massive conversion of ethanol to acetic acid, as usually occurs in the acetic acid bacteria, but without the transient accumulation of the highly toxic acetaldehyde. (nih.gov)
  • Acetaldehyde Market report makes some important proposals for a new project of Acetaldehyde Industry before evaluating its feasibility. (powershow.com)
  • The Acetaldehyde market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. (pitchengine.com)
  • The Acetaldehyde industry development trends and marketing channels are analyzed. (pitchengine.com)
  • It captures acetaldehyde oxime market trends, pays close attention to acetaldehyde oxime manufacturers and names suppliers. (marketpublishers.com)
  • The report then estimates 2015-2020 market development trends of Acetaldehyde industry. (powershow.com)
  • Also, depending on a persons genes, acetaldehyde can promote alcoholism. (diobeth.org)