A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
Coumarin derivative that acts as a long acting oral anticoagulant.
OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.
Agents that prevent clotting.
System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
Math calculations done for preparing appropriate doses of medicines, taking into account conversions of WEIGHTS AND MEASURES. Mistakes are one of the sources of MEDICATION ERRORS.
A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
Bleeding or escape of blood from a vessel.
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)
The study of the effects of drugs on mental and behavioral activity.
A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.

A placebo-controlled study of interaction between nabumetone and acenocoumarol. (1/76)

AIMS: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients treated with oral anticoagulants is generally discouraged due to the risk of interactions that could increase the risk of bleeding complications. Available data suggest the NSAID, nabumetone, does not produce such an interaction. We investigated whether nabumetone would interact with acenocoumarol, an oral anticoagulant widely used in some European countries. METHODS: A double-blind, randomized, placebo-controlled study was conducted evaluating nabumetone (1-2 g daily for up to 4 weeks) in osteoarthritis patients with thromboembolic risk previously stabilized on acenocoumarol. The primary efficacy end point was the proportion of patients whose International Normalized Ratio (INR) remained within established margins and whose acenocoumarol dose was not changed. Fifty-six patients were randomized to receive nabumetone (n=27) or placebo (n=29). RESULTS: Eighteen patients in each group (67% for nabumetone and 62% for placebo) completed the study without showing INR or acenocoumarol dose changes, and were considered as study successes. Nine patients (33%) with nabumetone and 11 (38%) with placebo were considered study failures in the intention-to-treat analysis (one patient on nabumetone and four on placebo did not complete the study due to reasons not related to INR and acenocoumarol dose changes). No significant differences were found between groups with regard to study successes. There were two minor bleeding complications, one in each group. Six patients per group presented with eight adverse experiences in each group. CONCLUSIONS: Treatment with nabumetone did not alter INR levels compared with placebo in patients stabilized on oral acenocoumarol who require NSAID therapy. These results suggest that nabumetone does not produce a clinically relevant interaction with acenocoumarol. In orally anticoagulated patients without other associated risk factors, treatment with nabumetone for up to 4 weeks does not require increased monitoring of INR levels.  (+info)

Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants. (2/76)

CYP2C9 is involved in the metabolism of the oral anticoagulants warfarin, phenprocoumon, and acenocoumarol. It is also responsible for the 5'-hydroxylation of the nonsteroidal anti-inflammatory drug lornoxicam. Therefore, lornoxicam and the oral anticoagulants are potential inhibitors of their metabolism. Their inhibitory potency was investigated in microsomes from six human livers. An approach to predict pharmacokinetic interactions of lornoxicam from in vitro inhibition data was developed. Where possible, the forecasts were verified by comparison with data from clinical interaction studies. The following increases in steady-state plasma concentrations or areas under the plasma concentration-time curve of the oral anticoagulants by concomitant lornoxicam medication were predicted (values in parentheses are for healthy volunteers): (S)-warfarin, 1. 58-fold (1.32-fold for racemate); racemic-acenocoumarol, 1.28-fold (1.09-fold); (R)-acenocoumarol, 1.10-fold (1.0-fold); racemic-phenprocoumon, 1.11-fold (1.18-fold); and (S)-phenprocoumon, 1.13-fold (1.24-fold). Lornoxicam 5'-hydroxylation was competitively inhibited in vitro by both phenprocoumon (K(i) = 1.2 +/- 0.4 microM) and acenocoumarol (K(i) = 5.5 +/- 3.5 microM). The present results indicate that relatively close predictions of the interactions of lornoxicam with oral anticoagulants from in vitro data are possible under the assumption that hepatic lornoxicam concentrations are similar to its total plasma concentrations. The degree of pharmacokinetic interactions exhibited by oral anticoagulants and lornoxicam is dependent on the respective contribution of CYP2C9 to their total clearance.  (+info)

Assessment of patient capability to self-adjust oral anticoagulant dose: a multicenter study on home use of portable prothrombin time monitor (COAGUCHECK). (3/76)

BACKGROUND AND OBJECTIVES: Self-testing and self-monitoring with portable prothrombin time (PT) monitors has been shown to be feasible and safe. However the ability of patients on chronic oral anticoagulant therapy (OAT) to self-adjust their dose without specific training has never been properly evaluated. The aims of this study were to evaluate: 1) the ability of patients on chronic OAT to self-adjust their dose without specific training; 2) the integration of a portable PT monitor (Coagucheck, Roche Diagnostics, Germany) for home use into routine patient care in anticoagulation clinics. DESIGN AND METHODS: A nested case-control study was conducted in four centers of the Italian Federation of Anticoagulation Clinics (FCSA). Patients (n=78) on stable OAT for at least 6 months (cases: 47 men, 31 women, age range: 18-75 years) were enrolled on a volunteer basis after passing an Abbreviated Mental Test and providing informed consent. After three instruction sessions on the use of Coaguchek, subjects performed the PT test at home, communicated the INR results to the Center and suggested the dose adjustment and date for next control as they thought appropriate. However, they were requested to follow the prescription made by the Center. Controls (78 subjects) matched by age (+/- 5 years), sex and therapeutic range with the cases, were selected from among those who attended the anticoagulation clinics and managed by usual care. RESULTS: When compared with the dose prescribed by the Clinic, the dose suggested by warfarin and acenocoumarol users was equal to or within +/- 6% of the mean weekly dose in 80% and 82% of suggestions, respectively. Time spent in the therapeutic range during the study was the same (80%) for cases and controls. INTERPRETATION AND CONCLUSIONS: Selected patients on chronic anticoagulant therapy can acquire a satisfactory ability for self-adjustment of OAT dose without specific training.  (+info)

Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. (4/76)

The oral anticoagulant acenocoumarol is given as a racemic mixture. The (S)-enantiomer is rapidly cleared and is the reason why only (R)-acenocoumarol contributes to the pharmacological effect. The objective of the study was to establish the cytochrome P450 (CYP) enzymes catalyzing the hydroxylations of the acenocoumarol enantiomers. Of various cDNA-expressed human CYPs, only CYP2C9 hydroxylated (S)-acenocoumarol. Hydroxylation occurred at the 6-, 7-, and 8-position with equal K(m) values and a ratio of 0.9:1:0.1 for V(max). CYP2C9 also mediated the 6-, 7-, and 8-hydroxylations of (R)-acenocoumarol with K(m) values three to four times and V(max) values one-sixth times those of (S)-acenocoumarol. (R)-Acenocoumarol was also metabolized by CYP1A2 (6-hydroxylation) and CYP2C19 (6-, 7-, and 8-hydroxylation). In human liver microsomes one enzyme only catalyzed (S)-acenocoumarol hydroxylations with K(m) values < 1 microM. In most of the samples tested the 7-hydroxylation of (R)-acenocoumarol was also catalyzed by one enzyme only. The 6-hydroxylation was catalyzed by at least two enzymes. Sulfaphenazole could completely inhibit in a competitive way the hydroxylations of (S)-acenocoumarol and the 7-hydroxylation of (R)-acenocoumarol. The 6-hydroxylation of (R)-acenocoumarol could be partially inhibited by sulfaphenazole, 40 to 50%, and by furafylline, 20 to 30%. Significant mutual correlations were obtained between the hydroxylations of (S)-acenocoumarol, the 7-hydroxylation of (R)-acenocoumarol, the 7-hydroxylation of (S)-warfarin, and the methylhydroxylation of tolbutamide. The results demonstrate that (S)-acenocoumarol is hydroxylated by a single enzyme, namely CYP2C9. CYP2C9 is also the main enzyme in the 7-hydroxylation of (R)-acenocoumarol. Other enzymes involved in (R)-acenocoumarol hydroxylation reactions are CYP1A2 and CYP2C19. Drug interactions must be expected, particularly for drugs interfering with CYP2C9. Also, drugs interfering with CYP1A2 and CYP2C19 may potentiate acenocoumarol anticoagulant therapy.  (+info)

Low molecular weight heparin versus oral anticoagulants in the long-term treatment of deep venous thrombosis. (5/76)

PURPOSE: The purpose of this study was to evaluate whether low molecular weight heparin (LMWH) could be equal or more effective than conventional oral anticoagulants (OAs) in the long-term treatment of deep venous thrombosis (DVT). METHODS: One hundred fifty-eight patients with symptomatic DVT of the lower limbs confirmed by means of duplex ultrasound scan were randomized to receive 3 to 6 months' treatment with nadroparine calcium or acenocoumarol. Quantitative and qualitative duplex scan scoring systems were used to study the evolution of thrombosis in both groups at 1, 3, 6, and 12 months. RESULTS: During the 12-month surveillance period, two (2.5%) of the 81 patients who received LMWH and seven (9%) of the 77 patients who received OAs had recurrence of venous thrombosis (not significant). In the LMWH group no cases of major bleeding were found, and four cases (5.2%) occurred in the OA group (not significant). The mortality rate was nine (11.1%) in the LMWH group and 7.8% in the OA group (not significant). The quantitative mean duplex scan score decreased in both groups during the follow-up and had statistical significance after long-term LMWH treatment on iliofemoral DVT (1, 3, 6, and 12 months), femoropopliteal DVT (1-3 months), and infrapopliteal DVT (first month). Duplex scan evaluation showed that the rate of venous recanalization significantly increased in the common femoral vein at 6 and at 12 months and during each point of follow-up in the superficial and popliteal veins in the LMWH group. Reflux was significantly less frequent in communicating veins after LMWH treatment (17.9% vs 32.2% in the OA group). The reflux rates in the superficial (22.4% in the LMWH group, 30.6% in OA group) and deep (13.4% vs 17.7%) venous system showed no significant differences between groups. CONCLUSIONS: The unmonitored subcutaneous administration of nadroparine in fixed daily doses was more effective than oral acenocoumarol with laboratory control adjustment in achieving recanalization of leg thrombi. With nadroparine, there was less late valvular communicating vein insufficiency, and it was at least as efficacious and safe as oral anticoagulants after long-term administration. These results suggest that LMWHs may therefore represent a real therapeutic advance in the long-term management of DVT.  (+info)

Optimal oral anticoagulant intensity to prevent secondary ischemic and hemorrhagic events in patients after infrainguinal bypass graft surgery. Dutch BOA Study Group. (6/76)

OBJECTIVES: The purpose of this study was to determine the optimal intensity of oral anticoagulation in patients who participated in a randomized trial of oral anticoagulants or aspirin after infrainguinal bypass graft surgery. METHODS: The distribution of patient-time spent in international normalized ratio (INR) classes of 0.5 INR unit was calculated assuming a linear change between successive measurements. INR-specific incidence rates of ischemic and hemorrhagic events were calculated as the ratio of the number of events at a certain INR category and the total patient-time spent in that class. The relationship between INR class and event rates was quantified by rate ratios calculated in a Poisson regression model. RESULTS: In 1326 patients (mean age, 69 years) 41,928 INR measurements were recorded in 1698 patient-years. Patients spent 50% of the total time within the target range of 3.0 to 4.5 INR. Most of the patient-time (60%) was spent between 2.5 and 3.5 INR. For each increasing class of 0.5 INR, the incidence of ischemic events (n = 154, INR data on event available in 49%) decreased by a factor of 0.97 (95% CI, 0.87-1.08). The incidence of major bleeding (n = 123, INR data on event available in 65%) increased significantly by a factor of 1.27 (95% CI, 1.19-1.34) for each increasing 0.5 INR category. The optimal target range was 3.0 to 4.0 INR, with an incidence of 3.8 events (0.9 ischemic and 2.9 hemorrhagic) per 100 patient-years. CONCLUSIONS: The target range of 3.0 to 4.0 INR is the optimal range of achieved anticoagulation intensity and is safe for the prevention of ischemic events in patients after infrainguinal bypass graft surgery.  (+info)

Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators. (7/76)

BACKGROUND: In patients with idiopathic deep venous thrombosis, continuing anticoagulant therapy beyond three months is associated with a reduced incidence of recurrent thrombosis during the period of therapy. Whether this benefit persists after anticoagulant therapy is discontinued is controversial. METHODS: Patients with a first episode of idiopathic proximal deep venous thrombosis who had completed three months of oral anticoagulant therapy (with warfarin, in 97 percent of the cases and acenocoumarol in 3 percent) were randomly assigned to the discontinuation of oral anticoagulants or to their continuation for nine additional months. The primary study outcome was recurrence of symptomatic, objectively confirmed venous thromboembolism during at least two years of follow-up. RESULTS: The primary intention-to-treat analysis showed that of 134 patients assigned to continued oral anticoagulant therapy, 21 had a recurrence of venous thromboembolism (15.7 percent; average follow-up, 37.8 months), as compared with 21 of 133 patients assigned to the discontinuation of oral anticoagulant therapy (15.8 percent; average follow-up, 37.2 months), resulting in a relative risk of 0.99 (95 percent confidence interval, 0.57 to 1.73). During the initial nine months after randomization (after all patients received three months of therapy), 1 patient had a recurrence while receiving oral anticoagulant therapy (0.7 percent), as compared with 11 of the patients assigned to the discontinuation of oral anticoagulant therapy (8.3 percent; P=0.003). The incidence of recurrence after the discontinuation of treatment was 5.1 percent per patient-year in patients in whom oral anticoagulant therapy was discontinued after 3 months (95 percent confidence interval, 3.2 to 7.5 percent; average interval since discontinuation, 37.2 months) and 5.0 percent per patient-year in patients who received an additional 9 months of oral anticoagulant therapy (95 percent confidence interval, 3.1 to 7.8 percent; average interval since discontinuation, 29.4 months). None of the recurrences were fatal. Four patients had non-fatal major bleeding during the extended period of anticoagulant therapy (3.0 percent). CONCLUSIONS: In patients with idiopathic deep venous thrombosis, the clinical benefit associated with extending the duration of anticoagulant therapy to one year is not maintained after the therapy is discontinued.  (+info)

Determination of coumarin-type anticoagulants in human plasma by HPLC-electrospray ionization tandem mass spectrometry with an ion trap detector. (8/76)

BACKGROUND: Coumarin-type anticoagulants are used for the long-term treatment and prevention of thromboembolic disorders. The identification of these drugs is crucial in patients with an increased prothrombin time of unknown origin. The aim of this study was to develop a sensitive and specific method for the simultaneous determination of phenprocoumon, acenocoumarol, and warfarin in human plasma by HPLC-electrospray ionization tandem mass spectrometry. METHODS: After addition of the internal standard, p-chlorowarfarin, plasma samples were extracted using Oasis MCX solid-phase extraction cartridges. The compounds were separated on a Symmetry C18 column (Waters) with a mobile phase of acetonitrile-1 g/L formic acid (75:25 by volume) at a flow rate of 0.5 mL/min. RESULTS: Extraction and separation of the three drugs and the internal standard were accomplished in 9 min. The overall extraction efficiency was >89% for all three compounds. The limits of detection were 1 microg/L for phenprocoumon and warfarin and 10 microg/L for acenocoumarol. Regression analysis of the calibration data revealed good correlation (r(2) >or=0.995) for all compounds. Within-run accuracies for quality-control samples were +/- 1% to 7% of the target concentration, with CVs <9%. CONCLUSIONS: The proposed method enables the unambiguous identification and quantification of phenprocoumon, warfarin, and acenocoumarol in both clinical and forensic specimens. This method combines a new, rapid solid-phase extraction procedure with an extremely fast chromatographic analysis, which is especially advantageous for clinical laboratories.  (+info)

The oral anticoagulant acenocoumarol is given as a racemic mixture. The (S)-enantiomer is rapidly cleared and is the reason why only (R)-acenocoumarol contributes to the pharmacological effect. The objective of the study was to establish the cytochrome P450 (CYP) enzymes catalyzing the hydroxylations of the acenocoumarol enantiomers. Of various cDNA-expressed human CYPs, only CYP2C9 hydroxylated (S)-acenocoumarol. Hydroxylation occurred at the 6-, 7-, and 8-position with equal Km values and a ratio of 0.9:1:0.1 for Vmax. CYP2C9 also mediated the 6-, 7-, and 8-hydroxylations of (R)-acenocoumarol with Km values three to four times and Vmax values one-sixth times those of (S)-acenocoumarol. (R)Acenocoumarol was also metabolized by CYP1A2 (6-hydroxylation) and CYP2C19 (6-, 7-, and 8-hydroxylation). In human liver microsomes one enzyme only catalyzed (S)-acenocoumarol hydroxylations with Km values | 1 mM. In most of the samples tested the 7-hydroxylation of (R)-acenocoumarol was also catalyzed by one enzyme
Reversal of anticoagulation can be needed in patients undergoing heart valve surgery. ROTEM® has been correlated with international normalized ratio (INR) in patients on warfarin but not with patients on acenocoumarol. This study investigates the reliability of ROTEM® for detecting INR values below the 1.5 threshold in patients on acenocoumarol therapy. Patients on oral anticoagulation with acenocoumarol after elective heart valve replacement were prospectively included in the study. INR and the ROTEM® were measured simultaneously. ROTEM® parameters included coagulation time, clot formation time, alpha angle, and maximal clot firmness after tissue factor activation (EXTEM). Concordance between INR and ROTEM® was analyzed by Lins concordance coefficient (LCC) and the correlation with Spearmans rho. Fifty-four consecutive patients (40 female; median age 67years) were included. Clotting time (CT) was the parameter that best correlated with INR (r=0.81, ...
OBJECTIVE: The aim of this study was to investigate the respective contribution of the different cytochrome P450 (CYP) 2C9 genetic polymorphisms to the interindividual variability of acenocoumarol pharmacodynamic response. METHODS: A total of 263 healthy volunteers were genotyped for CYP2C9*2, CYP2C9*3, CYP2C9*4, and CYP2C9*5 alleles, as well as for the nicotinamide adenine dinucleotide phosphate, reduced, quinone oxidoreductase 1 genetic polymorphism (NQO1*2). Moreover, the 5-flanking region of the CYP2C9 gene was investigated for new polymorphisms, and haplotype analysis was then performed. Finally, CYP2C9 phenotype was evaluated after a single oral dose of 4 mg of acenocoumarol. Factor VII coagulant activity was measured before and 24 hours after acenocoumarol intake. RESULTS: The CYP2C9*3 allele was the only nonsynonymous single nucleotide polymorphism (SNP) influencing acenocoumarol pharmacodynamics; the percentages of remaining factor VII were 60% +/- 19%, 39% +/- 17%, and 17% for ...
Acenocoumarol is an oral anticoagulant of the coumarin series, synthesized and developed in the Geigy laboratoires in the late 1960s and sold in the United States under the brand name of Sintrom. It lowers the prothrombin level of the blood. It is a white crystalline powder without taste and odor and has a molecular weight of 353. It is soluble in alkaline solutions but only slightly soluble in water and organic solvents. Chemically, acenocoumarol is 3-(alpha-acetonyl-4-nitrobenzyl)-4-hydroxycoumarin. ...
Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). The c.-1639G , A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Br J Haematol. 133 (2): 183&ndash, 7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310 ...
Acenocoumarol reference standards, CAS number: 152-72-7, for unparalleled analytical testing within the food and beverage sector. Buy online at LGC Standards.
In a study that our research group published recently in this journal, we demonstrated the relative safety of intra-articular injection in patients anticoagulated with acenocoumarol.1 These results agreed with those that had been previously reported for warfarin users.2,3 In the last few years, other oral anticoagulants have been made available for the secondary prevention of stroke or primary prevention of thrombotic phenomena of any type in patients in whom the anticoagulation achieved with acenocoumarol was difficult to control.4 After the experience in our registry of patients taking acenocoumarol, we reviewed our findings concerning complications following intra-articular injection of the knee and periarticular injection in shoulder in patients receiving dabigatran, a drug from a new generation of oral anticoagulants, with proven efficacy in the prevention of primary and secondary embolic events, which is especially indicated in patients in the geriatric population who have been diagnosed ...
Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use with AUGMENTIN may result in increased and prolonged blood levels of amoxicillin but not of clavulanate. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of AUGMENTIN and allopurinol. In common with other antibiotics, AUGMENTIN may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives. In the literature there are rare cases of increased international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. If co-administration is necessary, the prothrombin time or international normalised ratio should be carefully monitored with the addition or withdrawal of AUGMENTIN ...
The small size of the penicillins increases their potency, by allowing them to penetrate the entire depth of the cell wall. [url=http://valleyofshadowsanddreams.com/]viagra coupon[/url] The more you know about your anxiety the more you can avoid anxiety mistakes. List of excipients Citric acid anhydrous E330 Sodium Benzoate E211 Aspartame E951 Talc E553b Sodium citrate, anhydrous E331 Guar E412 Silicon dioxide, precipitated E551 Lemon flavouring, powdered Peach-apricot flavouring, powdered Orange flavouring, powdered 6. [url=http://valleyofshadowsanddreams.com/]viagra online[/url] However, in the literature there are cases of increased international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin.. ...
A 72-year old man had a collapse, severe hypertension (RR 200/100 mmHg), and malaise. He had a history of nicotine abuse and had been started on acenocoumarol because of pulmonary embolism four months earlier. At the outpatient clinic, his blood pressure was 180/95 mmHg and no oedema or skin lesions were observed. Screening blood tests showed acute renal insufficiency, with an estimated glomerular filtration rate (eGFR) that had decreased from 74 to 41 ml/min/1.73 m2 over the past five months. Urinary sediment microscopy showed 3-10 non-dysmorphic erythrocytes per view. The albumin/creatinine ratio was 44 mg/mmol. Abdominal ultrasonography did not show any postrenal obstruction or renal parenchymal abnormalities; the kidneys were normal in size. It did, however, show aneurysmatic dilatation of the abdominal aorta, maximum diameter 3.6 cm. Doppler ultrasonography did not show renal artery stenosis. Analyses of secondary causes of hypertension were negative. Because of progressive renal failure ...
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Proportions of patients who will achieve Recanalization of thrombus (complete i.e No thrombus is seen or partial i.e up to 50% of the lumen become patent.)on oral anticoagulant acenocoumarol during the study period of 2 year from randomization ...
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2 ...
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2 ...
Differences in relevance in the obtainable pharmacogenetic data, they also indicate differences inside the assessment of your high-quality of these association
A 62-year-old previously asymptomatic man was attended in the emergency room for anginal chest pain of 6 hours evolution. His medical history was remarkable for a combined aortic and mitral valve replacement 15 years previously for endocarditis (anticoagulation with acenocoumarol) and an aneurysm of the noncoronary sinus and ascending aorta, treated with an end-to-end anastomosis (Dacron graft) 2 months previously.. The patient was hemodynamically stable and had persistent pain. The physical examination was not contributory and the surgical wound appeared to be healing well. The ECG showed a known left bundle branch block without changes. During the initial evaluation, echocardiography showed inferior akinesia that was not present on the postoperative study, and a normally functioning graft, without clear visualization of the ascending aorta. An onset of infarction was suspected and 250 mg of aspirin was administered. Angioplasty was contemplated, and coronary angiography performed 60min after ...
In April 2003, Janet Woodcock, MD, the director of the FDAs Center for Drug Evaluation and Research, told an agency committee that the time had arrived to incorporate pharmacogenetic data in drug labels.
The maximum sample volume was calculated for a range of separation ratio values (a) and capacity ratio values (k) for the first eluted peak. The results are shown in figure 2.. ...
Historical PS ratio values for Benitec Biopharma (BNTC) over the last 10 years. The current P/S ratio for Benitec Biopharma as of January 22, 2020 is |strong||/strong|.
The aim of the study is to explore the contribution of genetic factors related either to drug metabolism (cytochrome P450 2C9) or to drug target (vitamin K epoxide reductase) to variability in the response to acenocoumarol among 222 healthy volunteers after a single oral dose. Associations between a pharmacodynamic index (reduction in factor VII activity and international normalized ratio [INR] change) and several genetic polymorphisms (VKORC1: -4931T,C, -4451C,A, -2659G,C, -1877A,G, -1639G,A, 497C,G, 1173C,T, and CYP2C9*3) were investigated using haplotype and univariate analyses. VKORC1 haplotypes were associated with the pharmacologic response, and this association can be explained only by the effect of the -1639G,A polymorphism (or alternatively by 1173C,T, which is in complete association with it). Indeed, it explains about one third of the variability of the pharmacologic response (37% of factor VII decrease and 30% of INR change). Moreover, the previously observed effect of the CYP2C9*3 ...
Rationale:. The narrow therapeutic range and wide inter-patient variability in dose requirement make anticoagulation response to coumarin derivatives unpredictable. As a result, patients require frequent monitoring to avert adverse effects and maintain therapeutic efficacy. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex 1 (VKORC1) jointly account for about 40% of the inter-individual variability in dose requirements. To date, several pharmacogenetic guided dosing algorithms for coumarin derivatives, predominately for warfarin, have been developed. However, the potential benefit of these dosing algorithms in terms of their safety and clinical utility has not been adequately investigated in randomised settings. Objective: To determine whether a dosing algorithm containing genetic information increases the time within therapeutic INR range during anticoagulation therapy with each of warfarin, acenocoumarol and phenprocoumon compared to a dosing regimen that ...
The Pregnant patients with a prosthetic mechanical valve are at high risk for valve thrombosis and the optimal treatment strategy in the pre-pregnancy period and during pregnancy itself is a matter of debate. Prosthetic heart valve (PHV) thrombosis is a rare condition with serious life-threatening complications diagnosed optimally by TOE followed by a radio-cinema; and which needs to be revaluated frequently by echocardiography transthoracic in case of an increase in trans valvular gradient. We report here a case of a 37-year-old woman, pregnant at 31 weeks of amenorrhea, with a double mitro-aortic mechanical replacement suspected dysfunction in front of an increase of trans-valvular gradient and confirmed on the radio cinema. The patient was treated with a low molecular weight heparin (LMWH); acetylsalicylic acid 160 mg daily; and oral anticoagulation (Acenocoumarol) with great clinical and biological results. In some cases; Pregnant patients with prosthetic valve thrombosis may be treated ...
In successive checkups in our offices, the patient showed improvement in terms of ischemia but polyarthritis persisted. The result for cryoglobulins was positive. Given the persistence of polyarthritis (although she continued to take MTX and leflunomide) and cryoglobulinemia, it was decided that she begin rituximab. Anticoagulation was maintained with acenocoumarol for a year, until the cryoglobulins were negative, when antiplatelet therapy was begun with ASA. During follow-up, the patient was repeatedly positive for ANA at low titers, with a homogeneous pattern, and was negative for anti-dsDNA. The immunological study was extended and we found antinucleosome antibodies and antibodies against the collagen-like region of C1q. The patient has continued to take rituximab, MTX, HCQ and ASA. She has not had any further ischemic episodes and there is no evidence of involvement of kidneys or of any other organ.. Discussion. We report the case of a patient with polyarthritis, a frequent cause for ...
Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene. CYP2C9 is an important cytochrome P450 enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes (data only for antifungal). Some 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin and other routinely prescribed drugs such as acenocoumarol, tolbutamide, losartan, glipizide, and some nonsteroidal anti-inflammatory drugs. By contrast, the known extrahepatic CYP2C9 often metabolizes important endogenous compound such as serotonin and, owing to its epoxygenase activity, various polyunsaturated fatty acids, converting these fatty acids to a wide range of biological active products. In particular, CYP2C9 metabolizes arachidonic acid to the following eicosatrienoic acid epoxide (termed EETs) stereoisomer sets: ...
Background The indications for continuous oral anticoagulant treatment, the target interval and the procedures for withdrawing treatment have changed in the last 10 years.
[125 Pages Report] Check for Discount on Global Oral Anticoagulants Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Oral Anticoagulants Revenue,...
SCVS 2021 Abstracts: New Class Of Medication Yields Better Outcomes: Direct Oral Anticoagulants Improve Treatment Success For Lower Extremity Acute DVT
We offer a comprehensive line of reagents, calibrators, controls and buffers. Explore our BIOPHEN and HEMOCLOT lines, along with buffers that neutralize heparin to render a measurement specific for Direct Xa Inhibitors.
Miller AL, Loscalzo J. Miller A.L., Loscalzo J Miller, Amy L., and Joseph Loscalzo.. Management of Patients Receiving a Direct Oral Anticoagulant. Harrisons Online Updates Kasper D. Kasper D Kasper, Dennis. New York, NY: McGraw-Hill, 2019, http://accessmedicine.mhmedical.com/updatesContent.aspx?gbosid=497653§ionid=227114133. ...
Direct oral anticoagulants (DOACs) have distinct bleeding profiles and require individualized management approaches, according to a new review.
Despite the emergence of direct oral anticoagulants (DOAC) in recent years, vitamin K antagonists (VKA) remain popular due to clinician familiarity, superior anticoagulation efficacy for mechanical heart valves, ability to easily monitor efficacy, and availability of reversal agents [1-3]. VKA include warfarin, acenocoumarol, phenprocoumon, dicoumarol, tecarfarin, and fluindione [2]. In the United States, warfarin is the most frequently used VKA and is frequently associated with bleeding complications that require treatment in the emergency department (ED) [3]. Warfarin and other VKA work by inhibiting vitamin K-dependent carboxylation of coagulation factors II, VII, IX, and X [2, 4]. This reduces the activity of these clotting factors and reduces clotting ability [2]. Anticoagulant effects can be measured via the international normalized ratio (INR) and higher INR values reflect reduced ability to form blood clots [2, 3]. Risk of hemorrhage also increases with increasing INR, although patients ...
The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to establish a bio-based manufacturing process for the production of the commodity chemical 4-hydroxycoumarin (4-HC) in an economical and renewable way. 4-HC is a direct synthetic precursor used to manufacture widely used oral anticoagulants, such as warfarin, acenocoumarol, and phenprocoumon. In a .... ...
Blood thinners basically inhibit the appearance of fibrin; they prevent thrombosis, contribute to stopping the growth of existing blood clots, enhance the effects of blood clots in the endogenous fibrinolytic enzymes.. Anticoagulants are divided into 2 groups: a) direct anticoagulants - quick action (heparin sodium, nadroparin calcium, enoxaparin sodium, etc.), efficient in vitro and in vivo; b) antiakoagulyanty indirect (vitamin K antagonists) - long-acting (warfarin, phenindione, acenocoumarol, etc.), are in vivo only after a latent period ...
https://www.futuremarketinsights.com/reports/sample/REP-GB-10058. Direct Oral Anticoagulants: Market Dynamics. Adoption of direct oral anticoagulants over the exciting alternative to warfarin and is used for the first line choice of treatment for venous thromboembolism and atrial fibrillation which is expected to spur the global direct oral anticoagulants market. Growing approval from the FDA and CE mark for the direct oral anticoagulants will further boost the direct oral anticoagulants market in the near future. Rising cases of thrombosis which is the major cause of morbidity and mortality in various parts of the world is expected to further drive the direct oral anticoagulants market in the forecast period.. However, some factors which might restraint the growth of the direct oral anticoagulants include high cost when compared to warfarin and shorter acting dose which makes it important not to miss any doses. Furthermore, stringent regulations for development of drug is expected to restraint ...
Emily Jane s Discussions | Mechanical Heart Valve support group for people who are having mechanical heart valve & artificial & plastic heart valve re…
Ryan Saccuccis Discussions | Mechanical Heart Valve support group for people who are having mechanical heart valve & artificial & plastic heart valve…
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St. Jude Medical announced the launch of a U.S. IDE clinical trial of its St. Jude Medical Masters HP Series 15 mm mechanical heart valve in pediatric patients.
The study indicated that, after accounting for differences in baseline characteristics, there were no apparent differences in outcomes between patients who were and were not prescribed oral anticoagulants. There was also no relationship between the CHA2DS2-VASc score and the probability that patients had filled a prescription for an oral anticoagulant, and ultimately no evidence that the CHA2DS2-VASc risk score can effectively indicate the potential benefits of systemic oral anticoagulants for patients initiating hemodialysis with preexisting Afib.. Additional research is necessary to further guide using anticoagulants in this population.. For more information, read the research poster (which was presented at ASN) here.. ...
Alexandre da Silveira Gerzson, Lorenzo Grassi, Luis Artur Zenni Lopes e Lucia Hiromi Hiwatashi Gallicchio Dental surgeries performed in patients undergoing antiplatelet drugs and/or oral anticoagulants therapy is a controversial issue. Many professionals unaware of those medications or the proper means to treat those patients recommend, without any scientific basis, suspension or dosage alteration of those medications without consulting the physician assisting the patients. Objective: to perform a literature review on the proper and safer means employed to treat those patients, thus enlightening how to reach diagnosis, determine the previous examination to be requested as well as the risks arising from the maintenance or interruption of therapy with anticoagulants. This article also reviewed the drugs used for those purposes, their mechanism of action and clinical behavior, aiming to elucidate the real risks to which patients are exposed.. Anticoagulants, International normalized ratio, Blood ...
Signa Vitae is a journal designed to publish articles from the neonatal, pediatric, and adult intensive care, along with the emergency medicine.
Indications: Used to be a bleeding disorder, whether congenital or acquired, examination serves primarily to monitor patients on oral anticoagulant treatment based on anticoagulants. These drugs ...
A five-year-old KwaZulu-Natal boy made history when he became the youngest person in Africa to receive a mechanical heart implantation.
Mark Crowther, MD discusses the results of various analyzes regarding the reversal of direct oral anticoagulants, including PCCs and Tailored Reversal Agents idarucizumab and andexanet alfa., TV Network
The Hillingdon Method adjusts oral anticoagulant dosing based on the target and observed International Normalized Ratios (INR). Hillingdon Hospital is in Uxbridge, Middlesex in England.
Direct oral anticoagulants offer several advantages over warfarin, but reversal agents for most DOACs are not available, which puts patients at risk if they need emergency surgery or experience breakthrough bleeding. Food and Drug Administration-approved assays that measure DOACs activity also are lacking.
Laura Talamo, MD discusses the results of retrospective analysis of a random sample of patients prescribed direct oral anticoagulants (DOACs) for any indication from May 2011 through April 2016. , TV Network
When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH Academic Article ...
Maritime Strategies International has added an Annual Efficiency Ratio (AER) calculation of vessel CO2emissions to over 21,000 ships in its HORIZON asset valuation platform. The new feature displays AER estimates for 2020 and compares this
For 50 years, warfarin was the only choice for people who needed to take an oral anticoagulant (blood thinner). New drugs called direct oral anticoagulants…
/CNW Telbec/ - The statistics are sobering. In 2011, approximately 396 Quebecers received transplants and 59 died before receiving required organs. At years...
  • Comparative study of the clinical effect of acenocoumarol (Sintrom) and phenprocoumon (Marcoumar) in myocardial infarction and angina pectoris. (semanticscholar.org)
  • Manufacturer Cipla, India your acenocoumarol Sintrom ipratropium, in a method head to. (ncld.org)
  • Acenocoumarol (Sintrom) - This is a drug used to slow blood clotting. (medicineclue.com)
  • Liver injury is more common with other coumarin derivatives such as phenprocoumon and acenocoumarol, which are available in other countries but not in the United States. (richardvigilantebooks.com)
  • Acitrom (Acenocoumarol or Nicoumalone) 1mg Tablet is an oral anticoagulant that helps prevent harmful blood clots in the legs, lungs, brain, and heart. (biopharmzpharma.in)
  • Acenocoumarol (Nicoumalone) The t½ of acenocoumarol as such is 8 hours, but an active metabolite is produced so that overall t½ is about 24 hours. (pharmacy180.com)
  • In the United States, approximately 2.7-6.1 million patients had atrial fibrillation (AF) in 2010, and this number is expected to gradually increase to approximately 5.6 to 12 million by 2050.1, 2 ) The vitamin K antagonists (VKAs), warfarin and acenocoumarol, are prescribed for the treatment or prophylaxis of embolic AF or deep vein thrombosis (DVT). (ekjcp.org)
  • Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). (medicscientist.com)
  • Increased coagulation tests (prothrombin time/INR) and/or bleeding with vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). (com.bd)
  • Vitamin K: 'The product should not be consumed by people taking anticoagulants containing vitamin K antagonists (e.g. warfarin and acenocoumarol). (colwayinternational.com)
  • The required acenocoumarol dose and the risk of underanticoagulation and overanticoagulation are associated with the CYP2C9 and VKORC1 genotypes. (eur.nl)
  • Patients with polymorphisms in CYP2C9 and VKORC1 had a higher risk of overanticoagulation (up to 74%) and a lower risk of underanticoagulation (down to 45%) in the first month of treatment with acenocoumarol, but this effect diminished after 1-6 months. (eur.nl)
  • Intr-un studiu efectuat in Franta s-a constatat ca testarea farmacogenetica poate sa identifice un risc crescut de supradozare la 25% dintre persoanele care vor incepe terapia cu acenocoumarol (purtatorii alelei VKORC1 1639A si CYP2C9*3). (lamedic.ro)
  • Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. (udl.cat)
  • 11 ) Similarly, the maintenance dose of acenocoumarol is also affected by VKORC1 and CYP2C9 genes. (ekjcp.org)
  • A pharmacokinetic-pharmacodynamic model for predicting the impact of CYP2C9 and VKORC1 polymorphisms on fluindione and acenocoumarol during induction therapy. (cdc.gov)
  • Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation? (wikipedia.org)
  • A prespecified pooled analysis of the EINSTEIN-DVT and EINSTEIN-PE studies compared the efficacy and safety of rivaroxaban (15 mg twice-daily for 21 days, followed by 20 mg once-daily) with standard-therapy (enoxaparin 1.0 mg/kg twice-daily and warfarin or acenocoumarol). (biomedcentral.com)
  • If you take medicines that thin the blood to prevent blood clots, e.g. warfarin or acenocoumarol, the risk of bleeding may be increased. (zeepedia.com)
  • Including but not limited to acenocoumarol when sold or recommended as anticoagulants. (napra.ca)
  • 2304 Finally, a similar trial was conducted in European countries where weirder coumarol anticoagulants are fashionable-acenocoumarol and phenprocoumon. (bmj.com)
  • Biobarcode assay for the oral anticoagulant acenocoumarol. (cocites.com)
  • Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). (wikipedia.org)
  • Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol. (semanticscholar.org)
  • The androgen, Testolactone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. (genelabs.com)
  • Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma. (semanticscholar.org)
  • Monitor for changes in the therapeutic effect of Acenocoumarol if Testolactone is initiated, discontinued or dose changed. (genelabs.com)
  • 1 There is a growing interest in the identification of genetic variants of cytochrome P450 CYP2C9, which can modify its ability to inactivate warfarin and acenocoumarol, since a reduced CYP2C9 activity on these drugs would put patients at risk of over anticoagulation and subsequent bleeding complications. (ashpublications.org)
  • Patients with acute pulmonary embolism and no contraindication to anticoagulant therapy were randomly assigned - by card draw no less, demonstrating how far trial randomization has come in subsequent years - to receive anticoagulation with heparin and the coumarin-derivative acenocoumarol, or no anticoagulant. (nature.com)
  • Besides this, he was managed conservatively with anticoagulation using enoxaparin and acenocoumarol and followed up with echocardiographic evaluation of IVC and RA thrombus and INR monitoring. (austinpublishinggroup.com)
  • Individuals with PM phenotype (i.e. genotypes with homozygous or compound heterozygous *2 or *3 alleles) are at greater risk of severe bleeding during coumarin-based anticoagulation therapy with warfarin, acenocoumarol and phenprocoumon. (goffinmoleculartechnologies.com)
  • The dose of acenocoumarol is individualized by your doctor according to blood clotting time as determined by laboratory tests, called an INR, performed at regular intervals. (pharmachoice.com)
  • Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. (udl.cat)
  • Prescription medications (for treating interact with acenocoumarol, anisindione, bupropion, dicumarol rule provided an opportunity for all interested persons to submit their comments on or before January 23, 2012. (redlightoflove.com)
  • Acenocoumarol works by partially blocking the reuse of vitamin K in your liver. (pharmachoice.com)
  • Acenocoumarol is prescribed to prevent unwanted clots from forming if you have a condition that puts you at risk of this happening, such as atrial fibrillation, or if you have had a heart valve replacement . (lazoi.com)
  • In the present study, the effects of these polymorphisms on the risk of underanticoagulation and overanticoagulation over time after the start of acenocoumarol were investigated. (eur.nl)
  • Conclusions These results suggest that Acenocoumarol rs9652490 and rs11856808 polymorphisms are not related with risk for MS. This study adds to other published evidence indicating that, to date, the SNPs studied here could be useful risk biomarkers of developing essential tremor, but not other movement disorders. (seatra.org)
  • Acenocoumarol is a blood thinner agent prescribed to treat or prevent the formation of blood clots or thrombus in the blood vessels helps by dissolving the blood clots and reducing the complication of thromboembolic disorders. (medindia.net)
  • Acenocoumarol is used to prevent and treat blood clots in blood vessels e.g. (lazoi.com)
  • Acenocoumarol is used to treat and prevent blood clots in the veins by preventing blood clots from forming or from getting bigger, but it does not dissolve blood clots. (pharmachoice.com)
  • Some products that may interact with this drug include: "blood thinners" (such as acenocoumarol, warfarin), strontium. (parspharmed.com)
  • Concomitant use of Monk Cv Dry Syrup with blood thinners such as warfarin, acenocoumarol increases the risk of bleeding. (pharmeasy.in)
  • METHODS: In order to investigate the choice of the best molecule and treatment regimen for a given noncompliance pattern, we performed an in silico study with two oral anticoagulant agents, warfarin and acenocoumarol, each taken in one or two daily doses. (archives-ouvertes.fr)
  • The metabolism of Acenocoumarol can be decreased when combined with Entecavir. (drugbank.com)
  • Acenocoumarol can also lead to severe allergic reactions including pale red, dizziness, severe headache, itchy skin rash however, these are rare. (lazoi.com)
  • A 59-year-old patient with chronic obstructive pulmonary disease (emphysema) operated upon in childhood due to coarctation of the aorta, with aortic valve replacement surgery due to severe stenosis (anticoagulated with acenocoumarol), reported for two-lung transplantation. (medintensiva.org)
  • Tous les résultats de la recherche seront tirés du « National Drug Schedules » du site Web en anglais. (napra.ca)
  • L-carnitine, the active ingredient in the drug, can increase the effects of acenocoumarol, which may increase the chance of bruising or bleeding. (medicineclue.com)
  • RESULTS: Considering different patterns of noncompliance (including timing errors in drug intake and the phenomenon of drug holidays) and comparing warfarin with acenocoumarol, we identified different situations in which one agent (prescribed once or twice daily) could clearly minimise both the thromboembolic and haemorrhagic risks. (archives-ouvertes.fr)
  • The authors comment that CYP2C18 is only included in three PharmGKB pathways (there are actually four: clobazam, diclofenac, warfarin and acenocoumarol), while the other genes of the CYP2C locus are in many. (blogspot.com)
  • Each peach coloured, biconvex, round tablet contains acenocoumarol 1 mg. (pharmachoice.com)
  • Each white, flat-faced tablet, debossed with Paladin shield on one side and double scored on the other, contains acenocoumarol 4 mg. (pharmachoice.com)
  • Warfarin and acenocoumarol are commonly prescribed oral anticoagulant drugs that are used in the prevention and treatment of thromboembolic disorders across the world. (innovareacademics.in)
  • This case report highlights an instance wherein warfarin proved to provide a much more stable anticoagulant cover, as compared to that provided by acenocoumarol. (innovareacademics.in)
  • Anti-coagulant effect of acenocoumarol and warfarin enhanced by clarithromycin. (pharmacia1.com)
  • Oxytetracycline may increase the anticoagulant activities of Acenocoumarol. (drugbank.com)
  • Drugs.com Drugs.com international listings for acenocoumarol Diseases Database (DDB): 29202 Cesar J, García-Avello A, Navarro J, Herraez M (2004). (wikipedia.org)
  • Cytochrome P450 CYP2C9 is the principal catalyst of warfarin and acenocoumarol hydroxilation reactions in human liver microsomes. (ashpublications.org)

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