Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Creosote: A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Confidentiality: The privacy of information and its protection against unauthorized disclosure.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Fossil Fuels: Any combustible hydrocarbon deposit formed from the remains of prehistoric organisms. Examples are petroleum, coal, and natural gas.Biodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Naphthalimides: Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Chlorophenols: Phenols substituted with one or more chlorine atoms in any position.Chloromercuribenzoates: Chloride and mercury-containing derivatives of benzoic acid.p-Chloromercuribenzoic Acid: An organic mercurial used as a sulfhydryl reagent.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Microsomes: Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Aldehydes: Organic compounds containing a carbonyl group in the form -CHO.Acenaphthenes: Tricyclic ethylene-bridged naphthalene derivatives. They are found in petroleum residues and coal tar and used as dye intermediates, in the manufacture of plastics, and in insecticides and fungicides.HydrocarbonsDictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Nitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.Polyploidy: The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.Dictionaries, ChemicalNucleic Acid Denaturation: Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.Chromium Compounds: Inorganic compounds that contain chromium as an integral part of the molecule.CresolsChromates: Salts of chromic acid containing the CrO(2-)4 radical.Climate Change: Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.Chlorofluorocarbons, Ethane: A group of ethane-based halogenated hydrocarbons containing one or more fluorine and chlorine atoms.Potassium Dichromate: Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.Ammonia: A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Climate: The longterm manifestations of WEATHER. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Steam: Water in its gaseous state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Micro-Electrical-Mechanical Systems: A class of devices combining electrical and mechanical components that have at least one of the dimensions in the micrometer range (between 1 micron and 1 millimeter). They include sensors, actuators, microducts, and micropumps.Electricity: The physical effects involving the presence of electric charges at rest and in motion.Wind: The motion of air relative to the earth's surface.Energy-Generating Resources: Materials or phenomena which can provide energy directly or via conversion.Delivery of Health Care, Integrated: A health care system which combines physicians, hospitals, and other medical services with a health plan to provide the complete spectrum of medical care for its customers. In a fully integrated system, the three key elements - physicians, hospital, and health plan membership - are in balance in terms of matching medical resources with the needs of purchasers and patients. (Coddington et al., Integrated Health Care: Reorganizing the Physician, Hospital and Health Plan Relationship, 1994, p7)Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Renewable Energy: Forms of energy that are constantly and rapidly renewed by natural processes such as solar, ocean wave, and wind energy. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Optical Devices: Products or parts of products used to detect, manipulate, or analyze light, such as LENSES, refractors, mirrors, filters, prisms, and OPTICAL FIBERS.Puerto Rico: An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)Soil: The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.Translations: Products resulting from the conversion of one language to another.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Translating: Conversion from one language to another language.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Hispanic Americans: Persons living in the United States of Mexican (MEXICAN AMERICANS), Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Soil Microbiology: The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.United StatesGeologic Sediments: A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)Solid Phase Microextraction: A solventless sample preparation method, invented in 1989, that uses a fused silica fiber which is coated with a stationary phase. It is used for sample cleanup before using other analytical methods.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Mouth Protectors: Devices or pieces of equipment placed in or around the mouth or attached to instruments to protect the external or internal tissues of the mouth and the teeth.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Water Pollutants, Chemical: Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.Silicates: The generic term for salts derived from silica or the silicic acids. They contain silicon, oxygen, and one or more metals, and may contain hydrogen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th Ed)Lewis Acids: Any chemical species which accepts an electron-pair from a LEWIS BASE in a chemical bonding reaction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.Silicon Compounds: Inorganic compounds that contain silicon as an integral part of the molecule.Magnesium Silicates: A generic term for a variety of compounds that contain silicon, oxygen, and magnesium, and may contain hydrogen. Examples include TALC and some kinds of ASBESTOS.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.Silicate Cement: A relatively hard, translucent, restorative material used primarily in anterior teeth. (From Boucher's Clinical Dental Terminology, 4th ed, p50)Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
(1/26) Fungal metabolism of acenaphthene by Cunninghamella elegans.

The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized within 72 h of incubation approximately 64% of the [1,8-14C]acenaphthene added. The radioactive metabolites were extracted with ethyl acetate and separated by thin-layer chromatography and reversed-phase high-performance liquid chromatography. Seven metabolites were identified by 1H nuclear magnetic resonance, UV, and mass spectral techniques as 6-hydroxyacenaphthenone (24.8%), 1,2-acenaphthenedione (19.9%), trans-1,2-dihydroxyacenaphthene (10.3%), 1,5-dihydroxyacenaphthene (2.7%), 1-acenaphthenol (2.4%), 1-acenaphthenone (2.1%), and cis-1,2-dihydroxyacenaphthene (1.8%). Parallel experiments with rat liver microsomes indicated that the major metabolite formed from acenaphthene by rat liver microsomes was 1-acenaphthenone. The fungal metabolism of acenaphthene was similar to bacterial and mammalian metabolism, since the primary site of enzymatic attack was on the two carbons of the five-member ring.  (+info)

(2/26) occupational exposure to aromatic hydrocarbons at a coke plant: Part II. Exposure assessment of volatile organic compounds.

The objective of the study is to assess the external and internal exposures to aromatic hydrocarbons in the tar and oil naphthalene distillation processes at a coke plant. 69 workers engaged as operators in tar and oil naphthalene distillation processes and 25 non-exposed subjects were examined. Personal analyses of the benzene, toluene, xylene isomers, ethylbenzene, naphthalene, indan, indene and acenaphthene in the breathing zone air allowed us to determine the time weighted average exposure levels to the aromatic hydrocarbons listed above. The internal exposure was investigated by measurement of the urinary excretion of naphthols, 2-methylphenol and dimethylphenol isomers by means of gas chromatography with a flame ionization detection (GC/FID). Urine metabolites were extracted after enzymatic hydrolysis by solid-phase extraction with styrene-divinylbenzene resin. The time-weighted average concentrations of the hydrocarbons detected in the breathing zone air shows that the exposure levels of the workers are relatively low in comparison to the exposure limits. Statistically significant differences between average concentrations of aromatic hydrocarbons (benzene, toluene, xylene isomers) determined at the workplaces in the tar distillation department have been found. Concentrations of the naphthalene and acenaphthene detected in workers from the oil distillation department are higher that those from the tar distillation department. Concentrations of naphthols, 2-methoxyphenol and dimethylphenol isomers in the urine of occupationally exposed workers were significantly higher than those of non-exposed subjects. Concentrations of the 2-methoxyphenol and dimethylphenol isomers in urine were significantly higher for the tar distillation workers, whereas concentrations of naphthols were higher for the oil naphthalene distillation workers. Operators at the tar and naphthalene oil distillation processes are simultaneously exposed to a mixture of different hydrocarbons, mainly benzene and naphthalene homologues.  (+info)

(3/26) Nonphotic entrainment of the circadian body temperature rhythm by the selective ORL1 receptor agonist W-212393 in rats.

We synthesized a small-molecule opioid receptor-like 1 (ORL1) receptor agonist, 2-{3-[1-((1R)-acenaphthen-1-yl)piperidin-4-yl]-2,3-dihydro-2-oxo-benzimidazol-1-y l}-N-methylacetamide (W-212393), and investigated its effect on the circadian body temperature rhythm of rats. W-212393 has high affinity for ORL1 receptors in the rat cerebral cortex and human ORL1 receptors expressed in HEK293 cells with K(i) values of 0.76 and 0.50 nM, respectively. W-212393 concentration-dependently stimulated GTPgamma(35)S binding and its efficacy was similar to nociceptin/orphanin FQ (N/OFQ), suggesting that W-212393 is a full agonist at ORL1 receptors. W-212393 dose-dependently occupied ORL1 receptors following intraventricular or intraperitoneal administration, suggesting that W-212393 is a brain-penetrating compound. W-212393 (100 nM) and N/OFQ (100 nM) significantly suppressed the activity of spontaneously firing rat suprachiasmatic nucleus neurons. These suppressive effects were blocked by an ORL1 receptor antagonist, J-113397 (1 microM). W-212393 (3 mg kg(-1), i.p.) induced a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs. The magnitude of the W-212393 (0.3-3 mg kg(-1), i.p.)-induced phase advance was dose-dependent and greater than those produced by 8-hydroxy-2-(di-n-propylamino)tetralin (0.3-3 mg kg(-1), i.p.) or melatonin (0.3-3 mg kg(-1), i.p.). The W-212393 (3 mg kg(-1), i.p.)-induced phase advance was antagonized by J-113397 (10 mg kg(-1), i.p.).W-212393 (3 mg kg(-1), i.p.) significantly accelerated the re-entrainment of the body temperature rhythm to a 6 h advanced light-dark cycle. These results indicate that activation of ORL1 receptors contributes to the circadian entrainment and W-212393 may represent an interesting agent for the study of circadian rhythms.  (+info)

(4/26) Evolution of a strategy for the synthesis of structurally complex batzelladine alkaloids. Enantioselective total synthesis of the proposed structure of batzelladine F and structural revision.

Stereoselective synthesis of octahydro-5,6,6a-triazaacenaphthalenes 29 and 34 having the anti-relationship of the angular hydrogens flanking the pyrrolidine nitrogen confirmed suspicions that the relative configuration of the left-hand tricyclic guanidine fragment of batzelladine F should be revised to have the syn relationship of these hydrogens. Several strategies were examined for coupling tricyclic guanidine fragments to prepare potential structures for batzelladine F. Eventually, a convergent synthesis strategy was devised, whose central step was a fragment-coupling tethered-Biginelli reaction (Scheme 17). Using this approach we synthesized four potential structures of batzelladine F, 35-38. None of these compounds, nor their enantiomers, were identical to natural batzelladine F. Reinvestigation of mass spectra of natural batzelladine F, and fragments 88 and 89 obtained upon saponification of batzelladine F, demonstrated that the originally proposed connectivity of this alkaloid was also incorrect. The revised connectivity, 90, of natural batzelladine F depicted in Scheme 21 is proposed.  (+info)

(5/26) Functional and transcriptional analyses of the initial oxygenase genes for acenaphthene degradation from Sphingomonas sp. strain A4.

Sphingomonas sp. strain A4 is capable of utilizing acenaphthene as its sole carbon and energy source. To isolate the genes responsible for acenaphthene degradation, transposon mutagenesis was performed on strain A4 and four mini-Tn5-inserted mutants lacking the ability to utilize acenaphthene were isolated. In three of the four mini-Tn5 inserted mutants, the mini-Tn5s were inserted into the same locus (within about 16 kb) as the arhA1A2 genes, which had previously been identified as the genes encoding the terminal oxygenase components for the initial oxygenation of acenaphthene. The nucleotide sequence analysis of the corresponding 16.4 kb DNA fragment revealed the existence of 16 ORFs and a partial ORF. From these ORFs, the genes encoding the ferredoxin (ArhA3) and ferredoxin reductase (ArhA4) complementary to ArhA1A2 were identified. RT-PCR analysis suggested that a 13.5 kb gene cluster, consisting of 13 ORFs and including all the arhA genes, forms an operon, although it includes several ORFs that are apparently unnecessary for acenaphthene degradation. Furthermore, using gene disruption and quantitative RT-PCR analyses, the LysR-type activator, ArhR, required for expression of the 13.5 kb gene cluster was also identified. Transcription of the gene cluster by ArhR was induced in the presence of acenaphthene (or its metabolite), and a putative binding site (T-N11-A motif) for ArhR was found upstream from the transcription start point of arhA3.  (+info)

(6/26) Novel intermediates of acenaphthylene degradation by Rhizobium sp. strain CU-A1: evidence for naphthalene-1,8-dicarboxylic acid metabolism.

The acenaphthylene-degrading bacterium Rhizobium sp. strain CU-A1 was isolated from petroleum-contaminated soil in Thailand. This strain was able to degrade 600 mg/liter acenaphthylene completely within three days. To elucidate the pathway for degradation of acenaphthylene, strain CU-A1 was mutagenized by transposon Tn5 in order to obtain mutant strains deficient in acenaphthylene degradation. Metabolites produced from Tn5-induced mutant strains B1, B5, and A53 were purified by thin-layer chromatography and silica gel column chromatography and characterized by mass spectrometry. The results suggested that this strain cleaved the fused five-membered ring of acenaphthylene to form naphthalene-1,8-dicarboxylic acid via acenaphthenequinone. One carboxyl group of naphthalene-1,8-dicarboxylic acid was removed to form 1-naphthoic acid which was transformed into salicylic acid before metabolization to gentisic acid. This work is the first report of complete acenaphthylene degradation by a bacterial strain.  (+info)

(7/26) An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cells.

Diesel exhaust particles (DEPs) contain oxygen-containing polycyclic aromatic hydrocarbons (PAHs) called quinoid PAHs. Some quinoid PAHs generate free radicals as they undergo enzymatic and nonenzymatic redox cycling with their corresponding semiquinone radicals. Reactive oxygen species (ROS) produced by these reactions can cause severe oxidative stress connected with inflammatory processing. Although humans and animals are continuously exposed to these chemicals in the environment, little is known about which quinoid PAHs are active. In this study, we estimated the intracellular ROS production and nuclear factor kappa B (NF-kappaB) translocation in A549 cells exposed to isomers of quinoid PAHs having two to four rings. We found that both acenaphthenequinone (AcQ) and 9,10-phenanthrenequinone (PQ) enhanced ROS generation and that AcQ translocated NF-kappaB from the cytosol to the nucleus. However, PQ, which has been reported to induce apoptosis, did not influence NF-kappaB activation. In addition, AcQ induced cyclooxygenase-2 (COX-2) expression which is a key enzyme in the inflammatory processing involved in the activation of NF-kappaB. Upregulation of NF-kappaB and COX-2 expression by AcQ treatment was suppressed by the antioxidant N-acetylcysteine (NAC). These results provide that AcQ might play an important role in human lung inflammatory diseases as an air pollutant.  (+info)

(8/26) High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response.

There is an extensive evidence that corticotropin releasing factor (CRF) is hypersecreted in depression and anxiety, and blockade of CRF could have therapeutic benefit. We report preclinical data and the results of a clinical Phase I study with the novel nonpeptide CRF(1) antagonist NBI-34041/SB723620. Preclinical data conducted with different cell lines expressing human CRF receptors and in Wistar and Sprague-Dawley rats indicate that NBI-34041 is effective in reducing endocrine responses to pharmacological and behavioral challenge mediated by CRF(1) receptors. These specific properties and its well-documented safety profile enabled a clinical Phase I study with 24 healthy male subjects receiving NBI-34041 (10, 50, or 100 mg) or placebo for 14 days. Regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis was evaluated by intravenous stimulation with 100 microg of human CRF. Psychosocial stress response was investigated with the Trier Social Stress Test (TSST). Treatment with NBI-34041 did not impair diurnal adrenocorticotropic hormone (ACTH) and cortisol secretion or CRF evoked ACTH and cortisol responses but attenuated the neuroendocrine response to psychosocial stress. These results suggest that NBI-34041 is safe and does not impair basal regulation of the HPA system but improves resistance against psychosocial stress. NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders.  (+info)

*  Acenaphthene
... acenaphthene forms complexes with low valent metal centers. One example is (η6-acenaphthene)Mn(CO)3]+. Chemical reduction ... Acenaphthene was prepared the first time from coal tar by Marcellin Berthelot. Later Berthelot and Bardy synthesized the ... Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) consisting of naphthalene with an ethylene bridge connecting positions ... 261-274.doi:10.1002/9783527626915.ch16 Solubility of acenaphthene in various organic solvents[permanent dead link]. ...
*  Trans-acenaphthene-1,2-diol dehydrogenase
The systematic name of this enzyme class is (+/-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called ... In enzymology, a trans-acenaphthene-1,2-diol dehydrogenase (EC 1.10.1.1) is an enzyme that catalyzes the chemical reaction ... Hopkins RP, Drummond EC, Callaghan P (1973). "Dehydrogenation of trans-acenaphthene-1,2-diol by liver cytosol preparations". ... trans-acenaphthene-1,2-diol and NADP+, whereas its 3 products are acenaphthenequinone, NADPH, and H+. This enzyme belongs to ...
*  Cunninghamella elegans
Pothuluri, J. V.; Freeman, J. P.; Evans, F. E.; Cerniglia, C. E. (1992). "Fungal metabolism of acenaphthene by Cunninghamella ... acenaphthene, 1- and 2-methylnaphthalene, naphthalene, fluorene or benzo(a)pyrene. In the case of phenanthrene, C. elegans ...
*  Acenaphthoquinone
... is a quinone derived from acenaphthene. It is insoluble in water, but soluble in alcohol. It is used as an ...
*  Acenaphthylene
It is produced industrially by dehydrogenation of acenaphthene. More than 20% of the carbon in the universe may be associated ... Hydrogenation gives the more saturated compound acenaphthene. It functions as a ligand for some organometallic compounds. The ...
*  Friedel-Crafts reaction
reaction of acenaphthene plus succinic acid Organic Syntheses, Coll. Vol. 3, p. 6 (1955); Vol. 20, p. 1 (1940).Article link ...
*  Pigment Red 190
Although structurally a derivative of perylene, it is produced from acenaphthene. It is usually applied for cotton fabric, jig ...
*  Pigment Violet 29
Structurally, it is a derivative of perylene, although it is produced from acenaphthene. It is a less common dye compared to ...
*  Effluent guidelines
Regulated pollutants range from acenaphthene to zinc, with maximum allowed contamination levels in discharge water (wastewater ...
*  Coal tar
... acenaphthene, fluorene, phenol, cresols, pyridine, picolines, phenanthracene, carbazole, quinolines, fluoranthene. Many of ...
*  Zethrene
The melting point is 262 °C. The compound was originally synthesized by Erich Clar in 1955 from acenaphthene in one method and ...
*  C12H10
The molecular formula C12H10 may refer to: Acenaphthene Benzocyclooctatetraene 1,3,5,7,9-Cyclododecapentaen-11-yne ...
*  List of IARC Group 3 carcinogens
Further details can be found in the IARC Monographs Acenaphthene Acepyrene Aciclovir Acridine orange Acriflavinium chloride ...
*  List of EC numbers (EC 1)
... trans-acenaphthene-1,2-diol dehydrogenase EC 1.10.2.1: L-ascorbate-cytochrome-b5 reductase EC 1.10.2.2: ubiquinol-cytochrome-c ...
Acenaphthene - Wikipedia  Acenaphthene - Wikipedia
... acenaphthene forms complexes with low valent metal centers. One example is (η6-acenaphthene)Mn(CO)3]+. Chemical reduction ... Acenaphthene was prepared the first time from coal tar by Marcellin Berthelot. Later Berthelot and Bardy synthesized the ... Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) consisting of naphthalene with an ethylene bridge connecting positions ... 261-274.doi:10.1002/9783527626915.ch16 Solubility of acenaphthene in various organic solvents[permanent dead link]. ...
more infohttps://en.wikipedia.org/wiki/Acenaphthene
Acenaphthene  Acenaphthene
Sadowska, K.W.; Stepniewska, G.B.; Recko, W.M., Specific heat and enthalpy of fusion of acenaphthene and acenaphthylene, Przem ... Boyd, R.H.; Christensen, R.L.; Pua, R., The heats of combustion of acenaphthene, acenaphthylene, and fluoranthene. Strain and ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=C83329&Units=SI&Mask=B
Acenaphthene  Acenaphthene
Sadowska, K.W.; Stepniewska, G.B.; Recko, W.M., Specific heat and enthalpy of fusion of acenaphthene and acenaphthylene, Przem ... Sharma, B.L.; Gupta, S.; Tandon, S.; Kant, R., Physico-mechanical properties of naphthalene--acenaphthene eutectic system by ... Boyd, R.H.; Christensen, R.L.; Pua, R., The heats of combustion of acenaphthene, acenaphthylene, and fluoranthene. Strain and ... acenaphthene and «alpha»-nitronaphthalene, Russ. J. Phys. Chem. (Engl. Transl.), 1974, 48, 1595. [all data] ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?Source=1998RUU%2FMOK107-137&Units=CAL&Mask=1A8F
Category:Acenaphthene - Wikimedia Commons  Category:Acenaphthene - Wikimedia Commons
Media in category "Acenaphthene". The following 9 files are in this category, out of 9 total. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Acenaphthene&oldid=18951886" ...
more infohttps://commons.wikimedia.org/wiki/Category:Acenaphthene
Trans-acenaphthene-1,2-diol dehydrogenase - Wikipedia  Trans-acenaphthene-1,2-diol dehydrogenase - Wikipedia
The systematic name of this enzyme class is (+/-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called ... In enzymology, a trans-acenaphthene-1,2-diol dehydrogenase (EC 1.10.1.1) is an enzyme that catalyzes the chemical reaction ... Hopkins RP, Drummond EC, Callaghan P (1973). "Dehydrogenation of trans-acenaphthene-1,2-diol by liver cytosol preparations". ... trans-acenaphthene-1,2-diol and NADP+, whereas its 3 products are acenaphthenequinone, NADPH, and H+. This enzyme belongs to ...
more infohttps://en.wikipedia.org/wiki/Trans-acenaphthene-1,2-diol_dehydrogenase
Acenaphthene - Substance Information - ECHA  Acenaphthene - Substance Information - ECHA
Acenaphthene. ↓Other names: Regulatory process names [2] Trade names [1] IUPAC names [4] ...
more infohttps://echa.europa.eu/de/substance-information/-/substanceinfo/100.001.336
Acenaphthene - Substance Information - ECHA  Acenaphthene - Substance Information - ECHA
Acenaphthene. Regulatory process names 1 CAS names 1 IUPAC names 2 Other identifiers 1 ...
more infohttps://echa.europa.eu/fr/substance-information/-/substanceinfo/100.001.336
Acenaphthene 10 µg/mL in Acetonitrile- CAS Number 83-32-9  Acenaphthene 10 µg/mL in Acetonitrile- CAS Number 83-32-9
Buy Acenaphthene 10 µg/mL in Acetonitrile - CAS Number 83-32-9 from LGC Standards. Please login or register to view prices, ...
more infohttps://www.lgcstandards.com/PL/en/Acenaphthene-10-g-mL-in-Acetonitrile/p/DRE-L20505000AL
Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical Journal  Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol | Biochemical Journal
Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol Message Subject (Your Name) has forwarded a page to you from ... 1. The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was ... Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol. R P Hopkins ...
more infohttp://www.biochemj.org/content/108/4/577
Acenaphthenes | Article about Acenaphthenes by The Free Dictionary  Acenaphthenes | Article about Acenaphthenes by The Free Dictionary
Find out information about Acenaphthenes. C12H10 An unsaturated hydrocarbon whose colorless crystals melt at 92°C; insoluble in ... water; used as a dye intermediate and as an agent for inducing polyploidy Explanation of Acenaphthenes ... acenaphthene. (redirected from Acenaphthenes) acenaphthene. [‚as·ə′naf·thēn] (organic chemistry) C12H10 An unsaturated ... Acenaphthenes , Article about Acenaphthenes by The Free Dictionary https://encyclopedia2.thefreedictionary.com/Acenaphthenes ...
more infohttps://encyclopedia2.thefreedictionary.com/Acenaphthenes
Syntheses of novel bis(alkylimino)acenaphthene (BIAN) and tetrakis(arylimino)pyracene (TIP) ligands and studies of their redox...  Syntheses of novel bis(alkylimino)acenaphthene (BIAN) and tetrakis(arylimino)pyracene (TIP) ligands and studies of their redox...
The evolution of the present work began with the syntheses of novel bis(alkylimino)acenaphthene (BIAN) ligands. At the outset ... Syntheses of novel bis(alkylimino)acenaphthene (BIAN) and tetrakis(arylimino)pyracene (TIP) ligands and studies of their redox ...
more infohttps://repositories.lib.utexas.edu/handle/2152/ETD-UT-2009-08-222
Browsing  by Subject Acenaphthene ligands  Browsing by Subject "Acenaphthene ligands"
Mixed chalcogen-donor acenaphthene ligands L1-L3 [Acenap(EPh)(E'Ph)] (Acenap = acenaphthene-5,6-diyl; E/E' = S, Se, Te) were ...
more infohttps://research-repository.st-andrews.ac.uk/browse?type=subject&value=Acenaphthene+ligands
Acenaphthene Solubility In Ethanol China Manufacturers & Suppliers & Factory  Acenaphthene Solubility In Ethanol China Manufacturers & Suppliers & Factory
We are Professional Manufacturer of Acenaphthene Solubility In Ethanol company, Factory & Exporters specialize in Acenaphthene ... Find Acenaphthene Solubility In Ethanol Manufacturers & Suppliers from China. ... Home > Products > Acenaphthene Solubility In Ethanol. Acenaphthene Solubility In Ethanol - manufacturer, factory, supplier from ... A good Acenaphthene Solubility In Ethanol . perfectly packaged. fast delivery. Prudence Attipoe Prudence Attipoe May 06, 2019 4 ...
more infohttp://www.kylin-chemicals.com/dp-acenaphthene-solubility-in-ethanol.html
Resin Material Acenaphthene  Resin Material Acenaphthene
Source the best resin material acenaphthene wholesale direct from our factory in China here. ... providing high quality resin material acenaphthene made in China with competitive price. ... Resin Material Acenaphthene. CAS:83-32-9 C12H10 EINECS: 201-469-6 Jinjing acenaphthene, 95%Min, it is one of coal chemical ... Feel free to wholesale high quality resin material acenaphthene made in China from our factory. Come and check price with us. ...
more infohttp://www.washingoil.com/plasticizer-and-resin-material/resin-material-acenaphthene/
Fungal metabolism of acenaphthene by Cunninghamella elegans. Identification of metabolites from the degradation of fluoranthene...  Fungal metabolism of acenaphthene by Cunninghamella elegans. Identification of metabolites from the degradation of fluoranthene...
Fungal metabolism of acenaphthene by Cunninghamella elegans. Identification of metabolites from the degradation of fluoranthene ... Fungal metabolism of acenaphthene by Cunninghamella elegans. Article Abstract:. Acenaphthene, a polycyclic aromatic hydrocarbon ... The results showed that acenaphthene is degraded via hydroxylation of both the aliphatic and aromatic rings to hydroxylated and ... Comparisons with rat liver microsomes showed that the fungal and mammalian pathways of acenaphthene degradation were similar. ...
more infohttp://www.readabstracts.com/Biological-sciences/Fungal-metabolism-of-acenaphthene-by-Cunninghamella-elegans.html
Buy Online  Sigma Aldrich - BNAs - Sandy Loam | LGC Standards  Buy Online Sigma Aldrich - BNAs - Sandy Loam | LGC Standards
Purchase online BNAs - Sandy Loam RTC-CRM143-50G . High Quality CRMs, Reference Materials, Proficiency Testing & More at LGC Standards
more infohttps://www.lgcstandards.com/GB/en/BNAs-Sandy-Loam/p/RTC-CRM143-50G
Polycyclic aromatic hydrocarbon - Wikipedia  Polycyclic aromatic hydrocarbon - Wikipedia
acenaphthene. EPA, ATSDR acenaphthylene. EPA, ATSDR anthracene. EPA, ATSDR benz[a]anthracene[A]. EPA, ATSDR, EFSA ...
more infohttps://en.wikipedia.org/wiki/Polycyclic_aromatic_hydrocarbon
Mass Spectrometry of Priority Pollutants | SpringerLink  Mass Spectrometry of Priority Pollutants | SpringerLink
Acenaphthene Brian S. Middleditch, Stephen R. Missler, Harry B. Hines. Pages 7-8 ...
more infohttps://link.springer.com/book/10.1007/978-1-4684-3788-1
Patent US7272934 - System integration of a steam reformer and gas turbine - Google Patents  Patent US7272934 - System integration of a steam reformer and gas turbine - Google Patents
Acenaphthene. 0.3051. Phenanthrene. 0.2256. Other. 1.7539. Total. 3.40 mg/g of dry feed. ...
more infohttp://www.google.ca/patents/US7272934
  • Acenaphthene CAS NO 83 32 9 Properties Molecular Formula C12H10 Synonyms 1 2 Dihydroacenaphthene 1 8 Ethylenenaphthalene Melting Point 90 94 Boiling Point 279 Color white or yellowish Form crystalline powder Assay GC 95 97 98 99 General Description Acenaphthene is polycyclic aromatic hydrocarbon It is white crystals. (kylin-chemicals.com)
  • Acenaphthene Traits : White or slightly oblique oblique needle crystal. (jrtaji.com)