Acetanilides: Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Confidentiality: The privacy of information and its protection against unauthorized disclosure.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)AmidohydrolasesCytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Licensure: The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Tropical Medicine: The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.History, 20th Century: Time period from 1901 through 2000 of the common era.Hygiene: The science dealing with the establishment and maintenance of health in the individual and the group. It includes the conditions and practices conducive to health. (Webster, 3d ed)New Orleans: City in Orleans Parish (county), largest city in state of LOUISIANA. It is located between the Mississippi River and Lake Pontchartrain.Parasitic Diseases: Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.alpha-Macroglobulins: Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)History, 18th Century: Time period from 1701 through 1800 of the common era.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.History, 17th Century: Time period from 1601 through 1700 of the common era.History, 19th Century: Time period from 1801 through 1900 of the common era.Body Composition: The relative amounts of various components in the body, such as percentage of body fat.OklahomaEngineering: The practical application of physical, mechanical, and mathematical principles. (Stedman, 25th ed)IllinoisPublications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Rehabilitation: Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)ChicagoCommunity Integration: Policies and programs which ensure that DISPLACED PERSONS and chronic illnesses receive the support and SOCIAL SERVICES needed to live in their communities.
(1/2) Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys.

The studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (CGT-P) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of Plasmodium cynomolgi. Administered intramuscularly as a suspension in an oleaginous vehicle, CGT-P (i) provided long-term protection against single and repetitive challenges of rhesus monkeys with sporozoites of the drug-susceptible B and Ro strains, (ii) effected prompt clearance of parasitemia in established infections, and (iii) delayed relapse. Protection was equated to absence of parasites on thick blood films, negative results when blood was transferred to susceptible recipients, and inability to activate infection by splenectomy. Eventual loss of protection was not related to emergence of parasites resistant to cycloguanil (CGT). Although protection varied from monkey to monkey, its mean duration was related directly to size of CGT-P dose and size of particles in the suspension. Urinary excretion studies indicated that protection persisted as long as the daily output of CGT did not fall below that attained with the parenterally administered hydrochloride salt at a dose equivalent to 0.015 mg of CGT per kg. Studies on infections with the resistant Ro/PM strain showed that the activity of CGT-P was compromised severely by resistance to pyrimethamine. Attempts to minimize this liability by concomitant administration of 4,4'-diacetyldiaminodiphenylsulfone met with limited success. These results suggest that even the best of the repository preparations of CGT-P, with or without 4,4'-diacetyldiaminodiphenylsulfone, would be useful only in areas where Plasmodium falciparum and Plasmodium vivax are fully susceptible to chlorguanide and pyrimethamine.  (+info)

(2/2) Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone.

In the course of a clinical trial of acedapsone therapy in 17 patients with lepromatous leprosy, the rate of response to therapy was measured by inoculation of mice with Mycobacterium leprae recovered from biopsy specimens of skin lesions obtained before treatment and at intervals of 4, 12, and 24 weeks after institution of treatment. The susceptibility of each isolate of M. leprae to dapsone (4,4'-diaminodiphenylsulfone [DDS]) was measured by passaging organisms that had multiplied in mice to new groups of untreated mice and to mice treated with DDS incorporated in the mouse chow in concentrations of 10(-5), 3 x 10(-5), and 10(-4) g/100 ml. The rate of response to acedapsone therapy and the susceptibility of patient strains of M. leprae to DDS varied widely among patients. All isolates were inhibited from multiplication by treatment of mice with 10(-4) g of DDS per 100 ml; all but two isolates were susceptible to 3 x 10(-5) g of DDS per 100 ml; and 17 of 36 isolates, representing nine patient strains, were susceptible to 10(-5) g of DDS per 100 ml. Plasma levels of DDS measured in the mice administered these diets show that the minimal inhibitory concentration of DDS for M. leprae isolated from untreated patients is about 3 ng/ml. No relationship could be demonstrated between DDS susceptibility of pretreatment isolates of M. leprae and the rate at which patients responded to acedapsone therapy. Neither acedapsone treatment of patients nor DDS treatment of mice appeared to select genotypically more resistant M. leprae.  (+info)

*  Acedapsone
... (INN) is an antimicrobial drug, which also has antimalarial activity. Acedapsone, or 1399 F, is a diacetyl compound ... Acedapsone is conveniently prepared by acetylation of dapsone. (in French) E. Fourneau, J. et Th. Tréfouël, F. Nitti, D. Bovet ... 4',4 ' ' ' -Sulfonylbisacetanilide (acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and ...
*  Leprostatic agent
Acedapsone is a derivative of dapsone that has little activity against M. leprae but is converted to an active dapsone ... The following agents are leprostatic agents: acedapsone clofazimine dapsone desoxyfructo-serotonin diucifon ethionamide ...
*  List of MeSH codes (D02)
... acedapsone MeSH D02.886.590.625 --- phenylmethylsulfonyl fluoride MeSH D02.886.590.700 --- sulfonamides MeSH D02.886.590.700. ...
*  List of drugs: Ac
... acedapsone (INN) acediasulfone (INN) acedoben (INN) acefluranol (INN) acefurtiamine (INN) acefylline clofibrol (INN) acefylline ...
Acedapsone - Wikipedia  Acedapsone - Wikipedia
Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity. Acedapsone, or 1399 F, is a diacetyl compound ... Acedapsone is conveniently prepared by acetylation of dapsone. (in French) E. Fourneau, J. et Th. Tréfouël, F. Nitti, D. Bovet ... 4',4 ' ' ' -Sulfonylbisacetanilide (acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and ...
more infohttps://en.wikipedia.org/wiki/Acedapsone
Acedapsone
        -
        Leprostatic Agents,  Antimalarials,  Anti-inflammatory Agents,  Anti-Infectives, ...  Acedapsone - Leprostatic Agents, Antimalarials, Anti-inflammatory Agents, Anti-Infectives, ...
Acedapsone side effects and Toxicity No information avaliable Acedapsone Patient Information 1. Patients should use ACZONE® Gel ... Acedapsone Pharmacology Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and ... Acedapsone Indication For the treatment and management of leprosy and dermatitis herpetiformis ... Acedapsone Chemical_Formula C12H12N2O2S ... Acedapsone Melting Point 175.5 oC Acedapsone H2O Solubility 380 ...
more infohttp://pharmacycode.com/Acedapsone.html
Category:Acetanilides - Wikimedia Commons  Category:Acetanilides - Wikimedia Commons
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
more infohttps://commons.wikimedia.org/wiki/Category:Acetanilides
CA2704853C - Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties 
        - Google...  CA2704853C - Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties - Google...
Acedapsone; Acetosulfone Sodium; Alamecin; Alexidine; Amdinocillin; Amdinocillin Pivoxil; Amicycline; Amifloxacin; Amifloxacin ...
more infohttps://patents.google.com/patent/CA2704853C/en
Volume 24, Issue 3 | The American Journal of Tropical Medicine and Hygiene  Volume 24, Issue 3 | The American Journal of Tropical Medicine and Hygiene
Acedapsone (DADDS) Treatment of Leprosy Patients in the Karimui of Papua New Guinea: Status at Six Years * D. A. Russell, C. C ... Acedapsone (DADDS), a repository sulfone given by injection five times a year, has been used since 1967 for the treatment of ... They were then treated as outpatients with intramuscular acedapsone (225 mg every 12 weeks) or oral dapsone (50 mg daily). They ...
more infohttp://www.ajtmh.org/content/journals/14761645/24/3
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information  Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
Acedapsone [USAN:INN:BAN] View Synonyms. View Structure. Description:. Acetylated sulfone that is slowly metabolized to give ...
more infohttps://druginfo.nlm.nih.gov/drugportal/rn/77-46-3
The American Journal of Tropical Medicine and Hygiene | Volume 28, Issue 3  The American Journal of Tropical Medicine and Hygiene | Volume 28, Issue 3
Acedapsone * in the Prevention of Leprosy: Field Trial in Three High Prevalence Villages in Micronesia † Authors: D. A. Russell ... people in a Micronesian population experiencing an annual leprosy incidence rate of about 7/1,000 were offered 15 acedapsone ( ...
more infohttp://www.ajtmh.org/content/journals/14761645/28/3
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious
     disease using alpha(2)...  US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...
Further examples of anti-parasitic compounds include but are not limited to Acedapsone; Amodiaquine Hydrochloride; Amquinate; ... Additional examples of antibacterial agents include but are not limited to Acedapsone; Acetosulfone Sodium; Alamecin; Alexidine ...
more infohttp://patents.com/us-9566348.html
Civil and Environmental Engineering - Research Output
     - University of Illinois at Urbana-Champaign  Civil and Environmental Engineering - Research Output - University of Illinois at Urbana-Champaign
Clark, M. P., Bahr, J. A., Bierkens, M. F. P., Cai, X., Hogue, T. S., Luce, C. H., Lundquist, J. D., Mackay, D. S., van Meerveld, H. J. I., Rajaram, H., Sanchez-Vila, X. & Troch, P. A. 2017 In : Water Resources Research.. Research output: Contribution to journal › Article ...
more infohttps://experts.illinois.edu/en/organisations/civil-and-environmental-engineering/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontoperiodical%2Farticle
GST Rate & HSN Code Chapter 30 for Pharmaceutical Products  GST Rate & HSN Code Chapter 30 for Pharmaceutical Products
Dapsone (DDS), acedapsone (DADDS), solopsone and clofazimine. View GST 30049056. Chloroquine, amodiaquine, mefloquine, quinine ... Dapsone (DDS), acedapsone (DADDS), solopsone and clofazimine. View GST 30049056. Chloroquine, amodiaquine, mefloquine, quinine ...
more infohttps://www.seair.co.in/gst/hsn-code-pharmaceutical-products.aspx
Leprosy among children under 15 years of age: literature review  Leprosy among children under 15 years of age: literature review
... and two with acedapsone (one dose every 10 weeks for seven months in both). The meta-analysis showed a reduction in the ... incidence of leprosy among the contacts with patients, varying from 30% to 72%, with the use of dapsone, acedapsone, or ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000200196&lng=en&tlng=en
ITC (Indian Tariff Code) for PHARMACEUTICAL PRODUCTS  ITC (Indian Tariff Code) for PHARMACEUTICAL PRODUCTS
ITC 30049055 Dapsone (DDS), acedapsone (DADDS), solopsone and clofazimine. ITC 30049056 Chloroquine, amodiaquine, mefloquine, ...
more infohttps://howtoexportimport.com/ITC-Indian-Tariff-Code-for-PHARMACEUTICAL-PRODUCTS-875.aspx
Leprostatic agent - Wikipedia  Leprostatic agent - Wikipedia
Acedapsone is a derivative of dapsone that has little activity against M. leprae but is converted to an active dapsone ... The following agents are leprostatic agents: acedapsone clofazimine dapsone desoxyfructo-serotonin diucifon ethionamide ...
more infohttps://en.wikipedia.org/wiki/Leprostatic_agent
US20060008504A1 - Flexible bone composite 
        - Google Patents  US20060008504A1 - Flexible bone composite - Google Patents
... such as Acedapsone, Acetosulfone Sodium, Clofazimine, Dapsone, Diathymosulfone, Glucosulfone Sodium, Hydnocarpic Acid, ... Acedapsone, Acediasulfone, Acetosulfone Sodium, Dapsone, Diathymosulfone, Glucosulfone Sodium, Solasulfone, Succisulfone, ...
more infohttps://patents.google.com/patent/US20060008504A1/en
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com  Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
... acedapsone, acediasulfone, acedoben, acefluranol, acefurtiamine, acefylline clofibrol, acefylline piperazine, aceglatone, ...
more infohttp://www.patents.com/us-20050002865.html
ATC code J04 - Wikipedia  ATC code J04 - Wikipedia
ATC code J04 Antimycobacterials is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup J04 is part of the anatomical group J Antiinfectives for systemic use.[1] Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QJ04.[2] National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. ...
more infohttps://en.wikipedia.org/wiki/ATC_code_J04