It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Journal Impact Factor
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Skin Diseases, Vesiculobullous
Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)
Encyclopedias as Topic
Mycobacterium avium Complex
A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.
Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys. (1/2)The studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (CGT-P) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of Plasmodium cynomolgi. Administered intramuscularly as a suspension in an oleaginous vehicle, CGT-P (i) provided long-term protection against single and repetitive challenges of rhesus monkeys with sporozoites of the drug-susceptible B and Ro strains, (ii) effected prompt clearance of parasitemia in established infections, and (iii) delayed relapse. Protection was equated to absence of parasites on thick blood films, negative results when blood was transferred to susceptible recipients, and inability to activate infection by splenectomy. Eventual loss of protection was not related to emergence of parasites resistant to cycloguanil (CGT). Although protection varied from monkey to monkey, its mean duration was related directly to size of CGT-P dose and size of particles in the suspension. Urinary excretion studies indicated that protection persisted as long as the daily output of CGT did not fall below that attained with the parenterally administered hydrochloride salt at a dose equivalent to 0.015 mg of CGT per kg. Studies on infections with the resistant Ro/PM strain showed that the activity of CGT-P was compromised severely by resistance to pyrimethamine. Attempts to minimize this liability by concomitant administration of 4,4'-diacetyldiaminodiphenylsulfone met with limited success. These results suggest that even the best of the repository preparations of CGT-P, with or without 4,4'-diacetyldiaminodiphenylsulfone, would be useful only in areas where Plasmodium falciparum and Plasmodium vivax are fully susceptible to chlorguanide and pyrimethamine. (+info)
Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. (2/2)In the course of a clinical trial of acedapsone therapy in 17 patients with lepromatous leprosy, the rate of response to therapy was measured by inoculation of mice with Mycobacterium leprae recovered from biopsy specimens of skin lesions obtained before treatment and at intervals of 4, 12, and 24 weeks after institution of treatment. The susceptibility of each isolate of M. leprae to dapsone (4,4'-diaminodiphenylsulfone [DDS]) was measured by passaging organisms that had multiplied in mice to new groups of untreated mice and to mice treated with DDS incorporated in the mouse chow in concentrations of 10(-5), 3 x 10(-5), and 10(-4) g/100 ml. The rate of response to acedapsone therapy and the susceptibility of patient strains of M. leprae to DDS varied widely among patients. All isolates were inhibited from multiplication by treatment of mice with 10(-4) g of DDS per 100 ml; all but two isolates were susceptible to 3 x 10(-5) g of DDS per 100 ml; and 17 of 36 isolates, representing nine patient strains, were susceptible to 10(-5) g of DDS per 100 ml. Plasma levels of DDS measured in the mice administered these diets show that the minimal inhibitory concentration of DDS for M. leprae isolated from untreated patients is about 3 ng/ml. No relationship could be demonstrated between DDS susceptibility of pretreatment isolates of M. leprae and the rate at which patients responded to acedapsone therapy. Neither acedapsone treatment of patients nor DDS treatment of mice appeared to select genotypically more resistant M. leprae. (+info)
WHO IRIS: Demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the reproduction of...
Demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the reproduction of relapses / H. E. Shortt and P. C. C. ...
Demonstration of a persisting exo-erythrocytic cycle in Plasmodium cynomolgi and its bearing on the production of relapses Public Health Classics ...
Proton Pump Inhibitors - Feather Law Group
Our seasoned attorneys have years of experience in seeking damages for people who have been injured by defective or mislabeled drugs. Many people can be uncertain about bringing a law suit and the complications it could cause in their life. We are here to help you to seek the compensation you deserve by holding the manufacturers of Proton Pump Inhibitors responsible for their negligence. In Mass Tort Drug Litigation, we never sue your doctor as they were following the recommendations made by the manufacturers of the drugs and are not at fault. We take the time to explain to you how the process works and are sensitive to the difficulties and concerns that you are facing as you deal with your injuries. Call 1-866-FEATHER today to learn how we can help you to seek damages for the injuries the manufacturers of Proton Pump Inhibitors caused you.. ...
Radical Curative Activity of a New 8-Aminoquinoline Derivative (CDRI 80/53) against Plasmodium cynomolgi B in Monkeys | The...
Abstract An analogue of primaquine, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1, 4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg × 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.
|jats:title|Key Points|/jats:title| |jats:p|Zoonotic P cynomolgi switches red cell tropism for reticulocytes...
|jats:title|Key Points|/jats:title| |jats:p|Zoonotic P cynomolgi switches red cell tropism for reticulocytes expressing Trf1 (CD71+) and DARC (CD234+). In the human host, P cynomolgi displays an almost identical rheopathobiology to P vivax.|/jats:p|
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Acedapsone is a derivative of dapsone that has little activity against M. leprae but is converted to an active dapsone ... The following agents are leprostatic agents: acedapsone clofazimine dapsone desoxyfructo-serotonin diucifon ethionamide ...
List of drugs: Ac
... acedapsone (INN) acediasulfone (INN) acedoben (INN) acefluranol (INN) acefurtiamine (INN) acefylline clofibrol (INN) acefylline ...
... (INN) is an antimicrobial drug, which also has antimalarial activity. Acedapsone is the INN for diacetyldapsone. It ... Acedapsone is conveniently prepared by acetylation of dapsone. Fourneau E, Tréfouël J, Nitti F, Bovet D (July 1937). " ... 4',4'''-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic ...
ATC code J04
... Antimycobacterials is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup J04 is part of the anatomical group J Antiinfectives for systemic use. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QJ04. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. ...
... (EMB, E) is a medication primarily used to treat tuberculosis. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii. It is taken by mouth. Common side effects include problems with vision, joint pain, nausea, headaches, and feeling tired. Other side effects include liver problems and allergic reactions. It is not recommended in people with optic neuritis, significant kidney problems, or under the age of five. Use during pregnancy or breastfeeding has not been found to cause harm. In the United States the FDA has raised concerns about eye issues in the baby if used during pregnancy. Ethambutol is believed to work by interfering with the bacteria's metabolism. Ethambutol was discovered in 1961. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines ...
Category:Unknown-importance pharmacology articles
ಕುಷ್ಠರೋಗ - ವಿಕಿಪೀಡಿಯ
ಈ ಖಾಯಿಲೆ ಹೊಂದಿರುವವರ ಜೊತೆ ಆರೋಗ್ಯವಂತರು ಸಂಪರ್ಕವನ್ನು ಹೊಂದಿದರೆ ಖಾಯಿಲೆ ಅಂಟುತ್ತದೆ ಎಂದು ತುಂಬಾ ವ್ಯಾಪಕವಾಗಿ ನಂಬಲಾಗಿದೆ. ಸಾಮಾನ್ಯವಾಗಿ, ಎಷ್ಟು ಹತ್ತಿರದಲ್ಲಿ ಸಂಪರ್ಕ ಹೊಂದಿದ್ದಾರೆ ಎನ್ನುವುದರ ಮೇಲೆ ಖಾಯಿಲೆ ಪ್ರಕಟವಾಗುವುದು ಅವಲಂಬಿಸಿದೆ. ಹಲವು ವಿಧದ ಸಂಪರ್ಕಗಳಲ್ಲಿ ಮನೆಯೊಳಗಿನ ಸಂಪರ್ಕವನಷ್ಟೇ ಸುಲಭವಾಗಿ ಗುರುರು ಹಿಡಿಯುವುದಕ್ಕೆ ಸಾಧ್ಯವಾಗುವುದು,ಆದಾಗ್ಯೂ ಸಂಪರ್ಕದ ನೈಜ ಘಟನೆ ಮತ್ತು ಅವುಗಳ ತೊಂದರೆ ಹಲವು ಅಧ್ಯಯನಗಳಲ್ಲಿ ...
Acedapsone - Wikipedia
Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity. Acedapsone is the INN for diacetyldapsone. It ... Acedapsone is conveniently prepared by acetylation of dapsone. Fourneau E, Tréfouël J, Nitti F, Bovet D (July 1937). " ... 4,4-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic ...
Acedapsone - Leprostatic Agents, Antimalarials, Anti-inflammatory Agents, Anti-Infectives, ...
Acedapsone side effects and Toxicity No information avaliable Acedapsone Patient Information 1. Patients should use ACZONE® Gel ... Acedapsone Pharmacology Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and ... Acedapsone Indication For the treatment and management of leprosy and dermatitis herpetiformis ... Acedapsone Chemical_Formula C12H12N2O2S ... Acedapsone Melting Point 175.5 oC Acedapsone H2O Solubility 380 ...
Category:Acetanilides - Wikimedia Commons
VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Flashcards by | Brainscape
Volume 24, Issue 3 | The American Journal of Tropical Medicine and Hygiene
Acedapsone (DADDS) Treatment of Leprosy Patients in the Karimui of Papua New Guinea: Status at Six Years * D. A. Russell, C. C ... Acedapsone (DADDS), a repository sulfone given by injection five times a year, has been used since 1967 for the treatment of ... They were then treated as outpatients with intramuscular acedapsone (225 mg every 12 weeks) or oral dapsone (50 mg daily). They ...
An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay | Protocol
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
CA2704853C - Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties - Google...
The American Journal of Tropical Medicine and Hygiene | Volume 28, Issue 3
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...
Leprostatic agent - Wikipedia
Rifampin orange discoloration of hands.
Namespaces Article Talk. The Journal of Antibiotics. Rifampicin has some effectiveness against vaccinia virus. Tarascon pocket pharmacopoeia: deluxe lab-pocket edition 15 ed. The activity of rifampicin against some species of mycobacteria can be potentiated by isoniazid through inhibiting mycolate synthesis  and ambroxol through host directed effects in autophagy and pharmacokinetics. Expert Review of Anti-Infective Therapy. International Programme on Chemical Safety. After two years of attempts to obtain more stable semisynthetic products, a new molecule with high efficacy and good tolerability was produced in and was named "rifampicin". Applied Microbiology.. ...
Dermatitis Herpetiformis, Familial disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Leprosy among children under 15 years of age: literature review
US20060008504A1 - Flexible bone composite - Google Patents
Iodohippurate in English with contextual examples
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
ATC code J04 - Wikipedia
ATC code J04 Antimycobacterials is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup J04 is part of the anatomical group J Antiinfectives for systemic use. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QJ04. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. ...
Ethambutol - Wikipedia
Ethambutol (EMB, E) is a medication primarily used to treat tuberculosis. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii. It is taken by mouth. Common side effects include problems with vision, joint pain, nausea, headaches, and feeling tired. Other side effects include liver problems and allergic reactions. It is not recommended in people with optic neuritis, significant kidney problems, or under the age of five. Use during pregnancy or breastfeeding has not been found to cause harm. In the United States the FDA has raised concerns about eye issues in the baby if used during pregnancy. Ethambutol is believed to work by interfering with the bacterias metabolism. Ethambutol was discovered in 1961. It is on the World Health Organizations List of Essential Medicines, the most effective and safe medicines ...
DeCS 2018 - July 31, 2018 version
DeCS 2016 - June 12, 2016 version
DeCS 2017 - July 04, 2017 version
Civil and Environmental Engineering - Research Output - University of Illinois at Urbana-Champaign
DeCS 2017 - December 21, 2017 version
Rxn chemicals: Impurities available for sale
- Acedapsone is conveniently prepared by acetylation of dapsone. (wikipedia.org)
- The following agents are leprostatic agents: acedapsone clofazimine dapsone desoxyfructo-serotonin diucifon ethionamide rifampicin rifapentine sulfameter thalidomide Leprosy is a chronic infectious disease caused by Mycobacterium leprae. (wikipedia.org)
- Acedapsone is a derivative of dapsone that has little activity against M. leprae but is converted to an active dapsone metabolite. (wikipedia.org)
- The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days. (bvsalud.org)
- A third matrix has been prepared containing 50 ww acedapsone in the 49,000 molecular weight copolymer used for 14C-WR-158122. (dtic.mil)
- In the study, 13 cases were diagnosed among 280 contacts who received 3 injections of acedapsone at 10 weeks interval as against 30 cases among 280 contacts who had the same number of placebo injections, during the follow-up period of 225 weeks. (bvsalud.org)
- Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity. (wikipedia.org)