Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.

Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys. (1/2)

The studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (CGT-P) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of Plasmodium cynomolgi. Administered intramuscularly as a suspension in an oleaginous vehicle, CGT-P (i) provided long-term protection against single and repetitive challenges of rhesus monkeys with sporozoites of the drug-susceptible B and Ro strains, (ii) effected prompt clearance of parasitemia in established infections, and (iii) delayed relapse. Protection was equated to absence of parasites on thick blood films, negative results when blood was transferred to susceptible recipients, and inability to activate infection by splenectomy. Eventual loss of protection was not related to emergence of parasites resistant to cycloguanil (CGT). Although protection varied from monkey to monkey, its mean duration was related directly to size of CGT-P dose and size of particles in the suspension. Urinary excretion studies indicated that protection persisted as long as the daily output of CGT did not fall below that attained with the parenterally administered hydrochloride salt at a dose equivalent to 0.015 mg of CGT per kg. Studies on infections with the resistant Ro/PM strain showed that the activity of CGT-P was compromised severely by resistance to pyrimethamine. Attempts to minimize this liability by concomitant administration of 4,4'-diacetyldiaminodiphenylsulfone met with limited success. These results suggest that even the best of the repository preparations of CGT-P, with or without 4,4'-diacetyldiaminodiphenylsulfone, would be useful only in areas where Plasmodium falciparum and Plasmodium vivax are fully susceptible to chlorguanide and pyrimethamine.  (+info)

Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. (2/2)

In the course of a clinical trial of acedapsone therapy in 17 patients with lepromatous leprosy, the rate of response to therapy was measured by inoculation of mice with Mycobacterium leprae recovered from biopsy specimens of skin lesions obtained before treatment and at intervals of 4, 12, and 24 weeks after institution of treatment. The susceptibility of each isolate of M. leprae to dapsone (4,4'-diaminodiphenylsulfone [DDS]) was measured by passaging organisms that had multiplied in mice to new groups of untreated mice and to mice treated with DDS incorporated in the mouse chow in concentrations of 10(-5), 3 x 10(-5), and 10(-4) g/100 ml. The rate of response to acedapsone therapy and the susceptibility of patient strains of M. leprae to DDS varied widely among patients. All isolates were inhibited from multiplication by treatment of mice with 10(-4) g of DDS per 100 ml; all but two isolates were susceptible to 3 x 10(-5) g of DDS per 100 ml; and 17 of 36 isolates, representing nine patient strains, were susceptible to 10(-5) g of DDS per 100 ml. Plasma levels of DDS measured in the mice administered these diets show that the minimal inhibitory concentration of DDS for M. leprae isolated from untreated patients is about 3 ng/ml. No relationship could be demonstrated between DDS susceptibility of pretreatment isolates of M. leprae and the rate at which patients responded to acedapsone therapy. Neither acedapsone treatment of patients nor DDS treatment of mice appeared to select genotypically more resistant M. leprae.  (+info)

Acedapsone is not a recognized or established medical term. It does not have a specific medical definition in the context of pharmacology, clinical medicine, or medical research.

However, Acedapsone is an investigational antibiotic that has been studied in clinical trials for its potential to treat various bacterial infections. It is a nitrofuran derivative and functions as an inhibitor of bacterial DNA synthesis. Despite some promising results from early studies, further development of Acedapsone as a therapeutic agent seems to have stalled, and it is not currently approved for use in any country.

In summary, while Acedapsone has been explored as a potential antibiotic, it does not have an official medical definition and is not widely used in clinical practice.

... (INN) is an antimicrobial drug, which also has antimalarial activity. Acedapsone is the INN for diacetyldapsone. It ... It is slightly soluble in water.[citation needed] Acedapsone is conveniently prepared by acetylation of dapsone. Fourneau E, ... 4',4'''-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic ...
Acedapsone is a derivative of dapsone that has little activity against M. leprae but is converted to an active dapsone ... The following agents are leprostatic agents: acedapsone clofazimine dapsone desoxyfructo-serotonin diucifon ethionamide ...
... acedapsone MeSH D02.886.590.625 - phenylmethylsulfonyl fluoride MeSH D02.886.590.700 - sulfonamides MeSH D02.886.590.700.120 - ...
... acedapsone (INN) acediasulfone (INN) acedoben (INN) acefluranol (INN) acefurtiamine (INN) acefylline clofibrol (INN) acefylline ...
Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity. Acedapsone is the INN for diacetyldapsone. It ... It is slightly soluble in water.[citation needed] Acedapsone is conveniently prepared by acetylation of dapsone. Fourneau E, ... 4,4-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic ...
Acedapsone Treatment of Leprosy Patients: Response versus Drug Disposition published on Jan 1977 by The American Society of ... In 22 lepromatous Filipino patients receiving their first injection of 225 mg acedapsone (DADDS), dapsone (DDS), and monoacetyl ...
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Oral drugs evaluated include sparfloxacin and acedapsone for leprosy; rifampicin, rifapentin and moxifloxacin for ...
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The most common side effects of bedaquiline in studies were nausea, joint and chest pain, and headache. The drug also has a black-box warning for increased risk of death and arrhythmias, as it may prolong the QT interval by blocking the hERG channel.[14] Everyone on bedaquiline should have monitoring with a baseline and repeated ECGs.[15] If a person has a QTcF of , 500 ms or a significant ventricular arrythmia, bedaquiline and other QT prolonging drugs should be stopped. There is considerable controversy over the approval for the drug, as one of the largest studies to date had more deaths in the group receiving bedaquiline that those receiving placebo.[16] Ten deaths occurred in the bedaquiline group out of 79, while two occurred in the placebo group, out of 81.[17] Of the 10 deaths on bedaquiline, one was due to a motor vehicle accident, five were judged as due to progression of the underlying tuberculosis and three were well after the person had stopped receiving bedaquiline.[16] However, ...
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225mg injection of acedapsone bimonthly and dapsone 100mg daily. The second regimen (regimen B) was the conventional MDT (WHO/ ...
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Acedapsone Preferred Term Term UI T000183. Date01/01/1999. LexicalTag NON. ThesaurusID ... Acedapsone Preferred Concept UI. M0000103. Registry Number. 0GZ72U84TN. Related Numbers. 77-46-3. Scope Note. Acetylated ... Acedapsone. Tree Number(s). D02.886.590.263.050. Unique ID. D000072. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D000072 ...
Acedapsone Preferred Term Term UI T000183. Date01/01/1999. LexicalTag NON. ThesaurusID ... Acedapsone Preferred Concept UI. M0000103. Registry Number. 0GZ72U84TN. Related Numbers. 77-46-3. Scope Note. Acetylated ... Acedapsone. Tree Number(s). D02.886.590.263.050. Unique ID. D000072. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D000072 ...
name.synonym = ACEDAPSONE filter.purchasability = all page.num = 1 Structural Results Found: (before additional filtering). SQL ... zinc12.docking.org/results/combination?name.synonym=ACEDAPSONE&filter.purchasability=all Embed Link to Results. ,div id=zinc- ... ACEDAPSONE AND f.ftype IN (3,7,11,12,14) AND ci.sub_id_fk IN (SELECT ci.sub_id_fk AS sub_id FROM catalog_item AS ci INNER JOIN ...
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ACECLIDINE HYDROCHLORIDE C96880 MCC2GG434J ACECLIDINE SALICYLATE C96882 RPK779R03H ACECLOFENAC C80534 0GZ72U84TN ACEDAPSONE ...
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ANTI-INFECTIVE AGENTS ACEDAPSONE ANTI-INFECTIVE AGENTS ACETYLCYSTEINE ANTI-INFECTIVE AGENTS ACLARUBICIN ANTI-INFECTIVE AGENTS ... KERATOLYTIC AGENTS ACEDAPSONE LEPROSTATIC AGENTS CLOFAZIMINE LEPROSTATIC AGENTS DAPSONE LEPROSTATIC AGENTS ETHIONAMIDE ... ANTIOXIDANTS ACEDAPSONE ANTIPARASITIC AGENTS ALBENDAZOLE ANTIPARASITIC AGENTS AMEBICIDES ANTIPARASITIC AGENTS AMODIAQUINE ... ANTIPLATYHELMINTIC AGENTS ACEDAPSONE ANTIPROTOZOAL AGENTS ALBENDAZOLE ANTIPROTOZOAL AGENTS AMEBICIDES ANTIPROTOZOAL AGENTS ...
Acedapsone(DADDS),Solopsone and Clofazimine: Nonsteroidal antiinflammatory, analgesics and antipyratic drugs Analgin with or ...
ACEDAPSONE. ACEDIA. ACEDIAMIN. ACEDIAMINE. ACEDIAMINES. Show all. Words From Letters: 39. AC. ACD. ACE. ACED. AD. ADC. ADE. AE ... ACEDAPSONE. ACEDIA. ACEDIAMIN. ACEDIAMINE. ACEDIAMINES. ACEDIAMINS. ACEDIAS. Show all. Words ending with ACED: 295. ABOUTFACED ...
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  • In 22 lepromatous Filipino patients receiving their first injection of 225 mg acedapsone (DADDS), dapsone (DDS), and monoacetyl DDS (MADDS) were present in plasma in approximately equal quantities. (ajtmh.org)
  • citation needed] Acedapsone is conveniently prepared by acetylation of dapsone. (wikipedia.org)