Acecainide: A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Cardiac Surgical Procedures: Surgery performed on the heart.Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Acetanilides: Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Confidentiality: The privacy of information and its protection against unauthorized disclosure.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)AmidohydrolasesCytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.Physician-Patient Relations: The interactions between physician and patient.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.United StatesPhenothiazines: Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.Administration, Rectal: The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.Prescription Drug Misuse: Improper use of drugs or medications outside the intended purpose, scope, or guidelines for use. This is in contrast to MEDICATION ADHERENCE, and distinguished from DRUG ABUSE, which is a deliberate or willful action.Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Tranquilizing Agents: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Writing: The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.Pharmacies: Facilities for the preparation and dispensing of drugs.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Pharmacy: The practice of compounding and dispensing medicinal preparations.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Schools, Pharmacy: Educational institutions for individuals specializing in the field of pharmacy.Tetrabenazine: A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.Chorea: Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)Vesicular Monoamine Transport Proteins: A family of vesicular amine transporter proteins that catalyze the transport and storage of CATECHOLAMINES and indolamines into SECRETORY VESICLES.Vesicular Biogenic Amine Transport Proteins: Integral membrane proteins of the LIPID BILAYER of SECRETORY VESICLES that catalyze transport and storage of biogenic amine NEUROTRANSMITTERS such as ACETYLCHOLINE; SEROTONIN; MELATONIN; HISTAMINE; and CATECHOLAMINES. The transporters exchange vesicular protons for cytoplasmic neurotransmitters.Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.Antiretroviral Therapy, Highly Active: Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.Paranoid Personality Disorder: A personality disorder characterized by the avoidance of accepting deserved blame and an unwarranted view of others as malevolent. The latter is expressed as suspiciousness, hypersensitivity, and mistrust.Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Burning Mouth Syndrome: A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.Octreotide: A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Human Body: The human being as a non-anatomical and non-zoological entity. The emphasis is on the philosophical or artistic treatment of the human being, and includes lay and social attitudes toward the body in history. (From J. Cassedy, NLM History of Medicine Division)Pruritus Vulvae: Intense itching of the external female genitals.Nanospheres: Spherical particles of nanometer dimensions.Sensation: The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.

Prediction of N-acetylprocainamide disposition kinetics in rat by combination of gamma variate and physiological pharmacokinetic model. (1/13)

Clearances and tissue/blood drug concentration ratios of N-acetylprocainamide (NAPA) in rats were determined. The clearances of NAPA in rat blood, liver, and kidney were 13.1, 4.88, and 8.24 ml.kg-1.min-1, respectively. Disposition kinetics of NAPA in rats was predicted with combination of gamma variate and physiological pharmacokinetic model. Equation for estimating the concentration of NAPA in rat blood following iv NAPA 40 mg.kg-1 was C = 55.06t(-0.220) exp(-0.00713t). Using r2 value as a criterion, we found a good agreement between predicted and observed concentrations in blood, lung, small intestine, heart, brain, and skin.  (+info)

Effects of antiarrhythmic drugs on phospholipid metabolism in Jurkat T cells. The potassium channel blocker, clofilium, specifically increases phosphatidylserine synthesis. (2/13)

Five antiarrhythmic drugs (bretylium, clofilium, propranolol, N-acetylprocainamide and amiodarone) were tested for their ability to modify phospholipid metabolism in Jurkat T lymphocytes. The five drugs, decreased in a dose-dependent mode the biosynthesis of both phosphatidylcholine and phosphatidylethanolamine, this effect was essentially due to impairment of either choline or ethanolamine uptake by the cells. The efficiency of the drugs to inhibit phosphatidylcholine and phosphatidylethanolamine synthesis was in the order: clofilium greater than amiodarone much greater than propranolol = bretylium much greater than N-acetylprocainamide. The IC50 varied from 3-5 microM for clofilium to greater than 200 microM for N-acetylprocainamide. In contrast, only clofilium, a voltage-gated K(+)-channel blocker, was able to increase phosphatidylserine synthesis with an EC50 = 50 microM. The effect of clofilium on phosphatidylserine synthesis thus mimics the effect of three other K(+)-channel blockers, quinine, 4-aminopyridine and tetraethylammonium, suggesting close relationships between phosphatidylserine synthesis and K+ channel activity.  (+info)

Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. (3/13)

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.  (+info)

Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma. (4/13)

Estimation of xenobiotic kinetics in humans frequently relies upon extrapolation from experimental data generated in animals. In an accompanying paper, we have presented a unique, generic, physiologically based pharmacokinetic model and described its application to the prediction of rat plasma pharmacokinetics from in vitro data alone. Here we demonstrate the application of the same model, parameterized for human physiology, to the estimation of plasma pharmacokinetics in humans and report a comparative evaluation against some recently published predictive methods that involve scaling from in vivo animal data. The model was parameterized through an optimization process, using a training set of in vivo data taken from the literature, and validated using a separate test set of published in vivo data. On average, the vertical divergence of the predicted plasma concentrations from the observed data, on a semilog concentration-time plot, was 0.47 log unit. For the training set, more than 80% of the predicted values of a standardized measure of the area under the concentration-time curve were within 3-fold of the observed values; over 70% of the test set predictions were within the same margin. Furthermore, in terms of predicting human clearance for the test set, the model was found to match or exceed the performance of three published interspecies scaling methods, all of which showed a distinct bias toward overprediction. We conclude that the generic physiologically based pharmacokinetic model, as a means of integrating readily determined in vitro and/or in silico data, is potentially a powerful, cost-effective tool for predicting human xenobiotic kinetics in drug discovery and risk assessment.  (+info)

Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. (5/13)

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More-sensitive enzyme-multiplied immunoassay technique for procainamide and N-acetylprocainamide in plasma, serum, and urine. (6/13)

A commercially available (Syva Co.) enzyme-multiplied immunoassay technique (EMIT) for the quantitative determination of procainamide (PA) and N-acetylprocainamide (NAPA) was modified to allow automated quantitative analysis of approximately 100 samples per day, in a working range of 0.1 to 2.0 micrograms/mL. Such a test was needed to evaluate the pharmacokinetic characteristics of controlled-release dosage forms characterized by long half-lives at low plasma concentration. Analytical recovery of PA and NAPA from serum, plasma, and urine was satisfactory, but at extreme ratios for PA:NAPA the accuracy of determining the lower-concentration component became unsatisfactory. In fact, however, we found no such ratios in 5400 clinical samples assayed by this procedure.  (+info)

Metabolites of procainamide and practolol inhibit complement components C3 and C4. (7/13)

Drug-induced systemic lupus erythematosus arises from toxic side-effects of administration of hydralazine, isoniazid, procainamide and practolol. Hydralazine and isoniazid are nucleophilic drugs and inhibit the covalent binding reaction of complement components, C3 and C4, an effect likely to lead to deposition of immune complexes (a feature of systemic lupus erythematosus). Procainamide and practolol do not themselves inhibit C3 and C4. A range of metabolites and putative metabolites of procainamide and practolol were synthesized, and tested for their ability to inhibit the covalent binding reactions of C3 and C4. The highly nucleophilic hydroxylamine metabolite of procainamide was strongly inhibitory in both tests, as was a putative hydroxylamine metabolite of practolol. These studies indicate a potential role for the hydroxylamine metabolites in mediating the toxic side-effects of procainamide and practolol, and emphasize the need for adequate measurements of hydroxylamine metabolites in human tissue.  (+info)

Four fluorescence polarization immunoassays for therapeutic drug monitoring evaluated. (8/13)

We evaluated four fluorescence polarization immunoassays--those for phenytoin, procainamide, N-acetylprocainamide (NAPA), and quinidine--from Roche Diagnostic Systems, done in the Cobas Bio FP centrifugal analyzer. The assays for phenytoin, NAPA, and quinidine demonstrated a linear response over the expected ranges of concentrations, and analytical recovery of test drug added to drug-free sera was greater than 90%. However, recovery in the procainamide assay was poor (69-82%) for samples containing greater than 8 mg/L, owing to nonlinearity. Results of method-comparison studies of the four assays paralleled the recovery studies, although the quinidine assay demonstrated a bias (1.0 mg/L higher) when compared with EMIT (Syva). The precision of the phenytoin assay was acceptable at all concentrations tested (total CV less than 7.0%). Imprecision of the other assays was significant at certain concentrations: total CV greater than 10.0% at subtherapeutic values for NAPA and quinidine, and greater than 9.0% for low (2.4 mg/L) and moderate concentrations (9.6 mg/L) of procainamide. Interferences were not significant for hemolyzed, icteric, or lipemic specimens or for specimens with added drug metabolites. The calibration curves for all four assays had good stability (greater than 60 days).  (+info)

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Acecainide (N-acetylprocainamide, NAPA) is an antiarrhythmic drug. Chemically, it is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug. It is only partially as active as procainamide; when checking levels, both must be included in the final calculation. In the early 1930s, Claude Beck was undertaking pioneer cardiac surgery at the Lakeside Hospital in Cleveland, Ohio. During and after his surgery he was facing problems with arrhythmias. These problems were investigated by Frederick R. Mautz. In these experiments he used drugs similar to cocaine, because these drugs were readily absorbed from mucous membranes and were also known to have some effect on the myocardium. Mautz tried procaine, but its action was short-lived owing to digestion by esterases. From procaine Mautz synthesized procainamide, which is not a substrate for esterases. Procainamide has the additional advantage of being active by mouth. ...
The objectives of this investigation were to characterize the disposition of fentanyl and alfentanil in 14 tissues in the rat, and to create physiological pharmacokinetic models for these opioids...
According to mathematical models of antiarrhythmic drug-receptor interactions, lidocaine binds preferentially to the sodium channel when the membrane is depolarized (i.e., the "inactivated" channel state). Therefore, the effect of lidocaine on conduction should be greater when the action potential duration is prolonged. To test this prediction in vivo we evaluated the rate-dependent effects of lidocaine on His-Purkinje conduction in the intact newborn canine heart. Lidocaines effect was assessed alone and then when given in combination with N-acetylprocainamide, a Class III antiarrhythmic agent. Utilizing intracardiac electrical stimulation and electrogram recording techniques, changes in the steady-state His-Purkinje conduction time during atrial pacing at increasingly rapid cycle lengths, changes in the conduction time of pacing trains delivered directly to the His bundle and changes in conduction time during His bundle extra stimulation were measured. After bilateral sectioning of the vagi ...
Our fluorescent westerns have components like transfer membranes with high protein binding capacity, protein free blockers and purified antibodies.
Dyphylline is used to treat and/or prevent the symptoms of bronchial asthma, chronic bronchitis, and emphysema. It works by opening up the bronchial tubes (air passages of the lungs) and increasing the flow of air through them. ...
Core Lab offers an Agilent Bioanalyzer platform for a wide range of applications with its lab-on-a-chip technology, high resolution and quantification of RNA and DNA, and protein analysis. Those applications can be also supported by the NanoDrop One or Qubit spectrophotometers.. The recently acquired Odyssey CLx imaging system by Li-Core provides infrared imaging support for all Western Blots applications with Image Studio software.. Core Lab is equipped with a Microplate Absorbance reader - iMark by BioRad with a wavelength range of 400-750 nm; a high performance solution for various immunoassays with colorimetric substrates as well as various protein assays.. For all cell sorting needs Core Lab offers BioRad S3e fully automated cell sorter, with two lasers and up to four fluorescence detectors, plus forward- and side-scatter detectors.. Lastly, Core Lab offers a gel-imaging system - BioRads GelDoc EZ. This compact and automated gel imaging instrument enables production of publication-quality ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
If your natural hair feels dry after you use certain products I may know why. Here are protein free products for your protein sensitive natural hair.
51-06-9 - REQCZEXYDRLIBE-UHFFFAOYSA-N - Procainamide [INN:BAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly. This may cause serious, heart-related side effects. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects ...
Im doing some practice problems, and this is from nursesaregreat.com: A procainamide drip is ordered (2 gm in 250 cc of D5W) to infuse at 4mg/kg/min. The patient weighs 165 lbs. Calculate the
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123 medications are known to interact with dyphylline. Includes Astelin (azelastine nasal), Combivent (albuterol/ipratropium), Combivent Respimat (albuterol/ipratropium).
The IUPHAR/BPS Guide to Pharmacology. dyphylline ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone ...
Table 3: Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18 ...
BIOL 240. This course will familiarize students with physiological defence mechanisms against chemical and biological agents. It will build on previously taught biological principles and provide a foundation for future immunoassay techniques. Prerequisite: BIOL355. ...
Ranitidine has been reported to affect the bioavailability of other drugs through several different mechanisms such as competition for renal tubular secretion, alteration of gastric pH, and inhibition of cytochrome P450 enzymes.. Procainamide: Ranitidine, a substrate of the renal organic cation transport system, may affect the clearance of other drugs eliminated by this route. High doses of ranitidine (e.g., such as those used in the treatment of Zollinger-Ellison syndrome) have been shown to reduce the renal excretion of procainamide and N-acetylprocainamide resulting in increased plasma levels of these drugs. Although this interaction is unlikely to be clinically relevant at usual ranitidine doses, it may be prudent to monitor for procainamide toxicity when administered with oral ranitidine at a dose exceeding 300 mg per day.. Warfarin: There have been reports of altered prothrombin time among patients on concomitant warfarin and ranitidine therapy. Due to the narrow therapeutic index, close ...
1980 March; 17(3): 359-63. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=6903434 • Bacteriology of 100 consecutive diabetic foot infections and in vitro susceptibility to ampicillin/sulbactam versus cefoxitin. Author(s): Borrero E, Rossini M Jr. Source: Angiology. 1992 April; 43(4): 357-61. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=1558322 • Bacteriology of chronic sinusitis after ampicillin therapy. Author(s): Jiang RS, Hsu CY. Source: American Journal of Rhinology. 1997 November-December; 11(6): 467-71. Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=9571747 • High-performance liquid chromatographic assay of ampicillin and its prodrug lenampicillin. Author(s): Marzo A, Monti N, Ripamonti M, Arrigoni Martelli E, Picari M. Source: Journal of Chromatography. 1990 May 16; 507: 235-9. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2380291 • High-performance liquid chromatographic assay of ampicillin, amoxicillin and ciclacillin in serum and urine using a pre-column reaction with ...
123 medications are known to interact with Dyphylline GG. Includes Advair Diskus (fluticasone/salmeterol), Allergy Multi-Symptom (acetaminophen/chlorpheniramine/phenylephrine), benztropine.
lysine drug combination glycine acetylsalicylate: acelysin solution used in the treatment of acute purulent-inflammatory diseases of the soft tissues; 9:1 mixture of lysine acetylsalicylate and glycine
Harnessing the potential of cells as complex biosensors promises the potential to create sensitive and selective detectors for discrimination of biodefense agents. Here we present toxin detection and suggest discrimination using cells in a multianalyte microphysiometer (MMP) that is capable of simultaneously measuring flux changes in four extracellular analytes (acidification rate, glucose uptake, oxygen uptake, and lactate production) in real-time. Differential short-term cellular responses were observed between botulinum neurotoxin A and ricin toxin with neuroblastoma cells, alamethicin and anthrax protective antigen with RAW macrophages, and cholera toxin, muscarine, 2,4-dinitro-phenol, and NaF with CHO cells. These results and the post exposure dynamics and metabolic recovery observed in each case suggest the usefulness of cell-based detectors to discriminate between specific analytes and classes of compounds in a complex matrix, and furthermore to make metabolic inferences on the cellular effects
87 matching references were found. Niedz, R.P.; Moshonas, M.G.; Peterson, B.; Shapiro, J.P.; Shaw, P.E., Analysis of sweet orange (Citrus sinensis (L.) Osbeck) callus cultures for volatile compounds by gas chromatography with mass selective detector, Plant Cell Tissue Organ Cult., 1997, 51, 3, 181-185, https://doi.org/10.1023/A:1005977501472 . [all data] Peterson, B.H., Some binary systems with acetamide, Proc. Iowa Acad. Sci., 1943, 50, 253-9. [all data] Boozer, C.E.; Hammond, G.S.; Hamilton, C.E.; Peterson, C., Air Oxidation of Hydrocarbons IV. The Effects of Varying Solvent and the Mechanism of Uninhibited Chain Termination, J. Am. Chem. Soc., 1955, 77, 3380-3. [all data] Park, T.; Rettich, T.R.; Battino, R.; Peterson, D.; Wilhelm, E., Solubility of gases in liquids: 14. bunsen coefficients for several fluorine-containing gases (freons) dissolved in water at 298.15 k., J. Chem. Eng. Data, 1982, 27, 324-6. [all data] Peterson, D.A.; Schlie, L.A., Stable pure sulfur discharges and associated ...
Most states mandate that cannabis testing labs analyze samples for any fungal or microbial growth resulting from production or handling, as well as for mycotoxins, which are toxins produced by fungi. With the potential to become lethal, continuous exposure to mycotoxins can lead to a buildup of progressively worse allergic reactions.. LCMS should be used to qualify and identify strains of mycotoxins. However, determining the amount of microorganisms present is another challenge. That testing can be done using enzyme linked immunosorbent assay (ELISA), quantitative polymerase chain reaction (qPCR) or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), with each having their advantages and disadvantages.. For mycotoxin analysis, select a high-sensitivity LC-MS/MS instrument. In addition to standard LC, using an MS/MS selective detector enables labs to obtain limits of detection up to 1000 times greater than conventional LC-UV instruments.. For qPCR and its ...
To create a SEM image a focused primary electron beam scans across a sample surface. Due to the electron bombarding secondary electrons (SE) as well as backscattered electrons (BSE) emit from the sample.. While secondary elecontrons have an energy lower than 50 eV, backscattered electrons show much higher energies.The different electrons are therefore detected by two different, energy selective detectors which convert them into signals, amplifys and visualizes them on a monitor. The result is a tremendously vivid surface image. Since secondary electrons can only be emitted from the surface the resolution of the corresponding image is very good. It ranges between 5 and 10 nm. Backscattered electrons are generated at greater depths. Therefore, the resolution of the corresponding image is significantly lower. SEM have a field depth that is much higher than the one from optical microscopes.. ...
Enzyme multiplied immunoassay technique (EMIT) is a common method for qualitative and quantitative determination of therapeutic and recreational drugs and certain proteins in serum and urine. It is an immunoassay in which a drug or metabolite in the sample competes with an drug/metabolite labelled with an enzyme, to bind to an antibody. The more drug there is in the sample, the more free enzyme there will be, and the increased enzyme activity causes a change in color. Determination of drug levels in serum is particularly important when the difference in the concentrations needed to produce a therapeutic effect and adverse side reactions is small, the therapeutic window. EMIT therapeutic drug monitoring tests provide accurate information about the concentration of such drugs such as immunosuppressant drugs and some antibiotics. EMIT urine assays for drugs such as cannabinoids, morphine, and amphetamine are designed to detect the drug itself or a metabolite of the drug present in a concentration ...
Take this medicine by mouth. You can take it with or without food. If it upsets your stomach, take it with food. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctors advice.. Talk to your pediatrician regarding the use of this medicine in children. While some products may be prescribed for children as young as 6 years old for selected conditions, precautions do apply.. ...
Sprawdź ile zapłacisz za lek procainamide controlled-release w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Thank you for sharing this Pharmacological Reviews article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
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Looking for online definition of Calcium acetylsalicylate in the Medical Dictionary? Calcium acetylsalicylate explanation free. What is Calcium acetylsalicylate? Meaning of Calcium acetylsalicylate medical term. What does Calcium acetylsalicylate mean?
were kept at submicromolar concentrations by foam fractioning and biological filtration (e.g., live sand).. Variable Fluorescence. Variable chlorophyll fluorescence kinetic transients were measured with a custom-built fast repetition-rate fluorometer using protocols described by Kolber et al. (14).. Lipid Analysis. Lipids were saponified, methylated, and extracted into hexane/methyl tertiary butyl ether as described (15). Fatty acid methyl esters were analyzed by GC/MS with an Agilent series 6890 GC system and 5973 mass selective detector, equipped with an HP5MS capillary column (i.d., 30 m × 0.25 mm; film thickness, 0.25 μm) with helium as the carrier gas.. Membrane Inlet MS. Light-dependent production and consumption of oxygen was measured by using a membrane inlet system attached to a Prisma QMS-200 (Pfeiffer, Nashua, NH) quadruple mass spectrometer with closed ion source recording at mass/charge (m/z) ratios of 32 (16O16O), 36 (18O18O), and 40 (Ar). The membrane inlet system was modified ...
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First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively characterized over the last three decades. However, the molecular mechanisms by which detergents influence membrane protein stability and function remain poorly understood, and elucidation of the dynamic detergent-lipid-protein interactions of solubilized membrane proteins is a largely unexplored research field. This study examined nine detergents upon nAChR solubilization and purification, to assess receptor lipid composition using GC (Gas Chromatography)-FID (Flame Ionization) and/or GC-MSD (Mass Selective Detectors), stability and aggregation state using A-SEC (Analytical Size-Exclusion Chromatography) and EM (Electron Microscopy), and planar lipid bilayers to measure ion channel function. Detergent solubilization of nAChR-enriched membranes did not result in significant native lipid depletion or destabilization. Upon purification, native lipid depletion occurred in all detergents, with lipid-analog ...
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively characterized over the last three decades. However, the molecular mechanisms by which detergents influence membrane protein stability and function remain poorly understood, and elucidation of the dynamic detergent-lipid-protein interactions of solubilized membrane proteins is a largely unexplored research field. This study examined nine detergents upon nAChR solubilization and purification, to assess receptor lipid composition using GC (Gas Chromatography)-FID (Flame Ionization) and/or GC-MSD (Mass Selective Detectors), stability and aggregation state using A-SEC (Analytical Size-Exclusion Chromatography) and EM (Electron Microscopy), and planar lipid bilayers to measure ion channel function. Detergent solubilization of nAChR-enriched membranes did not result in significant native lipid depletion or destabilization. Upon purification, native lipid depletion occurred in all detergents, with lipid-analog ...
Fruit Fusion Deep Conditioner Mask is a protein free powerhouse formula of antioxidants rich fruit extract blend that will help to protect your hair . It will instantly moisturize and smooth those frizzy hair strands. Created with both sealing and pene
大部分心律不整都可以有效地治療[2],包括藥物治療、置放心律調節器以及手術。心搏過速的藥物包括乙型交感神經阻斷劑或抗心律不整藥物如普魯卡因胺(procainamide),而後者在長期使用有較顯著的副作用。心律調節器通常用在有症狀且藥物治療無效之心搏過緩病患。抗凝血劑用在某些心律不規則(如心房顫動)的病患以降低如中風等併發症的風險。危及生命的心律不整需要緊急進行電擊治療,包括整流(Cardioversion)及去顫兩種[6]。 第Ⅰ類:鈉離子通道阻斷劑 本類藥物抑制快速性鈉離子通道,降低心肌去極化動作電位變化速率(Vmax),即動作電位第0相,延長不反應期及動作電位期間(action potential duration; ...
While reports of ketamine abuse are increasing, reports of ketamine deaths and tissue concentrations associated with fatalities are rare. We report here a case of a mixed drug fatality involving ketamine and ethanol. Ketamine analysis was carried out by gas chromatography with a nitrogen-phosphorus …
TY - JOUR. T1 - High-pressure liquid chromatographic assay of cefotaxime and desacetylcefotaxime in human myometrium. AU - Bawdon, R. E.. AU - Novick, W. J.. AU - Hemsell, D. L.. AU - Welch, W. D.. PY - 1984. Y1 - 1984. N2 - An analytic high-pressure liquid chromatographic (HPLC) procedure for the assay of desacetylcefotaxime and cefotaxime in gynecologic tissue was developed. Normal individuals undergoing elective hysterectomy were subjects in this study. Blood and myometrium were removed up to four hours after a l-g intramuscular dose of cefotaxime. Since cefotaxime is unstable in homogenized tissue at room temperature, the specimens must be maintained at 4 degree C during homogenization and extraction. Mean serum desacetylcefotaxime and cefotaxime levels were 3. 2 plus or minus 2. 0 mu g/ml and 6. 8 plus or minus 4. 4 mu g/ml, respectively. The mean myometrium concentrations of desacetylcefotaxime and cefotaxime were 8. 4 plus or minus 10. 0 mu g/g and 6. 3 plus or minus 8. 9 mu g/g, ...
... ,The Emit 2000 Phenytoin Assay is a homogeneous enzyme immunoassay intended for use in the quantitative analysis of phenytoin in human serum or plasma. Emit 2000 assays are designed for use with most chemistry analyzers.,medicine,medical supply,medical supplies,medical product
VIVO Alkaline Complete Protein is a premium plant-based protein with a complete amino acid profile, rich in BCAAs, that can help support your bodys pH balance, your immune health, and fuel muscle growth, with its easily digestible and fast acting formula. Fuel your healthy, active lifestyle.
For the determination of antibodies based on an immunoassay technique by incubation with at least three receptors R 1 , R 2 and R 3 which are present dissolved in a liquid phase and of which R 1 is an antigen which is capable of being specifically bound to the antibody to be determined, R 2 mediates the binding to the solid phase and R 3 carries a label, separation of the complex which forms from the solution by binding to a solid phase and measurement of the label in one of the phases, a conjugate is used as the receptor R 2 composed of a receptor capable of specific binding to R 1 and a substance S 1 , which can be specifically bound, and a conjugate of a receptor which can specifically bind to R 1 and a label is used as R 3 , wherein the immobilization of the complex which forms is mediated by binding to a component of the solid phase which can specifically bind S 1 .
75,000+ high-quality Invitrogen primary and secondary antibodies. Detect targets (85% proteome coverage) by flow cytometry, western blot, fluorescent imaging, cell analysis, and other immunoassay techniques.
75,000+ high-quality Invitrogen primary and secondary antibodies. Detect targets (85% proteome coverage) by flow cytometry, western blot, fluorescent imaging, cell analysis, and other immunoassay techniques.
75,000+ high-quality Invitrogen primary and secondary antibodies. Detect targets (85% proteome coverage) by flow cytometry, western blot, fluorescent imaging, cell analysis, and other immunoassay techniques.
Your condition will be monitored closely when you first begin therapy. Often, this drug is first started in a hospital or other monitored health care setting. Once you are on maintenance therapy, visit your doctor or health care professional for regular checks on your progress. Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.. Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be, and when you should contact him or her. Your doctor or health care professional also may schedule regular blood tests and electrocardiograms to check your progress.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or ...
... acecainide MeSH D02.241.223.100.054.055.105 --- benzocaine MeSH D02.241.223.100.054.055.650 --- procainamide MeSH D02.241. ...
... acecainide (INN) acecarbromal (INN) aceclidine (INN) aceclofenac (INN) acedapsone (INN) acediasulfone (INN) acedoben (INN) ...
Some acecainide can convert to procainamide. The deacetylation clearance of acecainide is 0.39 L/h compare to a total NAPA ... acecainide can cause cardiac toxicity that effects in torsades de pointes. Also acecainide can decrease renal function when it ... Acecainide is considered comparable in activity to its parent compound; however, acecainide levels will vary widely. Serum ... However, hypotension has been reported in association with a rapid injection of acecainide. In animals, acecainide has positive ...
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Some acecainide can convert to procainamide. The deacetylation clearance of acecainide is 0.39 L/h compare to a total NAPA ... acecainide can cause cardiac toxicity that effects in torsades de pointes. Also acecainide can decrease renal function when it ... Acecainide is considered comparable in activity to its parent compound; however, acecainide levels will vary widely. Serum ... However, hypotension has been reported in association with a rapid injection of acecainide. In animals, acecainide has positive ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
Detailed drug Information for Norpramin. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Do not take this medicine within 2 hours of taking antacids or medicine for diarrhea. Taking these products too close together may make this medicine less effective.. This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.. Before using any prescription or over-the-counter (OTC) medicine for colds or allergies, check with your doctor. These medicines may increase the chance of developing heatstroke or other unwanted effects, such as dizziness, dry mouth, blurred vision, and constipation, while ...
This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
... will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicines including other narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Do not drink alcoholic beverages, and check with your medical doctor or dentist before taking any of the medicines listed above, while you are using this medicine. This medicine may cause some people to become drowsy, dizzy, or lightheaded, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded. Dizziness, light-headedness, or fainting may ...
Buprenorphine (Generic Butrans, Buprenex, Subutex) is used to treat Pain and Opioid Dependence. Learn about Buprenorphine uses before beginning treatment with Pharmacist Tips and User Reviews!
If you have achlorhydria (absence of stomach acid) or hypochlorhydria (decreased amount of stomach acid), and you are taking itraconazole or ketoconazole, your doctor may want you to take your medicine with an acidic drink. You may dissolve your medicine in cola or seltzer water and drink the solution, or your may take your medicine with a glass of cola or seltzer water. Your doctor may suggest that you dissolve each capsule or tablet in a teaspoonful of weak hydrochloric acid solution to help you absorb the medicine better. Your health care professional can prepare the solution for you. After you dissolve the tablet in the acid solution, add this mixture to a small amount (1 or 2 teaspoonfuls) of water in a glass. Drink the mixture through a plastic or glass drinking straw. Place the straw behind your teeth, as far back in your mouth as you can. This will keep the acid from harming your teeth. Be sure to drink all the liquid to get the full dose of medicine. Next, swish around in your mouth ...
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children- Appropriate studies have not been performed on the relationship of age to the effects of eliglustat in the pediatric population. Safety and efficacy have not been established. Older adults- Although appropriate studies on the relationship of age to the effects of eliglustat have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. Breast-feeding- There are no adequate studies in women for ...
Acecainide pharmacokinetics in normal subjects of known acetylator phenotype. Biopharmaceutics & drug disposition. 1991 Nov;12( ...
... acecainide MeSH D02.241.223.100.054.055.105 --- benzocaine MeSH D02.241.223.100.054.055.650 --- procainamide MeSH D02.241. ...
Description of the drug droperidol Injection. - patient information, description, dosage and directions. What is droperidol Injection!
Xenazine is used to treat chorea (a movement disorder) that is caused by Huntington disease. Xenazine works in the central nervous system (CNS) to prevent the absorption of certain...
Description of the drug haloperidol. - patient information, description, dosage and directions. What is haloperidol!
Acecainide (theoretical), Amiodarone (theoretical), Arsenic Trioxide (theoretical), Azimilide (theoretical), Bretylium ( ...
This medicine is given as a shot under your skin, into a muscle or vein. A nurse or other trained health professional may give you this medicine or this medicine may be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. You might not use all of the medicine in each ampul or vial (glass container). Do not save an opened ampul or vial. If the medicine in the ampul or vial has changed color, or if you see particles in it, do not use it. Some patients may feel pain, stinging, tingling, or burning sensations at the place where they inject the medicine. Injecting the medicine after it has been warmed to room ...
N-Acetylprocainamide (NAPA or acecainide) is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic ...
Acecainide Current Synonym true false 159396014 N-acetylprocainamide Current Synonym true false ...
... acecainide, acecarbromal, aceclidine, ac clof nac, acedapsone, acediasulfone, acedoben, acefluranol, acefurtiamine, acefylline ...
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Detailed drug Information for Erythrocin Lactobionate Intravenous. Includes common brand names, drug descriptions, warnings, side effects and dosing information.Print coupons and compare prices.
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children- Serious side effects, such as convulsions (seizures), are more likely to occur in younger patients and would be of greater risk to infants than to older children or adults. In general, children are more sensitive to the effects of antihistamines. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects . Older adults- Elderly patients are usually more sensitive to the ...
Ciprofloxacin is used to treat bacterial infections in many different parts of the body. Ciprofloxacin oral liquid and tablets are also used to treat anthrax infection after inhalational exposure. Ciprofloxacin may mask or delay the symptoms of syphilis. It is not effective against syphilis infections.
Acecainide. Taking sulfamethoxazole and trimethoprim combination in combination with any of the following medications could ...