A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Surgery performed on the heart.
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.

Prediction of N-acetylprocainamide disposition kinetics in rat by combination of gamma variate and physiological pharmacokinetic model. (1/13)

Clearances and tissue/blood drug concentration ratios of N-acetylprocainamide (NAPA) in rats were determined. The clearances of NAPA in rat blood, liver, and kidney were 13.1, 4.88, and 8.24 ml.kg-1.min-1, respectively. Disposition kinetics of NAPA in rats was predicted with combination of gamma variate and physiological pharmacokinetic model. Equation for estimating the concentration of NAPA in rat blood following iv NAPA 40 mg.kg-1 was C = 55.06t(-0.220) exp(-0.00713t). Using r2 value as a criterion, we found a good agreement between predicted and observed concentrations in blood, lung, small intestine, heart, brain, and skin.  (+info)

Effects of antiarrhythmic drugs on phospholipid metabolism in Jurkat T cells. The potassium channel blocker, clofilium, specifically increases phosphatidylserine synthesis. (2/13)

Five antiarrhythmic drugs (bretylium, clofilium, propranolol, N-acetylprocainamide and amiodarone) were tested for their ability to modify phospholipid metabolism in Jurkat T lymphocytes. The five drugs, decreased in a dose-dependent mode the biosynthesis of both phosphatidylcholine and phosphatidylethanolamine, this effect was essentially due to impairment of either choline or ethanolamine uptake by the cells. The efficiency of the drugs to inhibit phosphatidylcholine and phosphatidylethanolamine synthesis was in the order: clofilium greater than amiodarone much greater than propranolol = bretylium much greater than N-acetylprocainamide. The IC50 varied from 3-5 microM for clofilium to greater than 200 microM for N-acetylprocainamide. In contrast, only clofilium, a voltage-gated K(+)-channel blocker, was able to increase phosphatidylserine synthesis with an EC50 = 50 microM. The effect of clofilium on phosphatidylserine synthesis thus mimics the effect of three other K(+)-channel blockers, quinine, 4-aminopyridine and tetraethylammonium, suggesting close relationships between phosphatidylserine synthesis and K+ channel activity.  (+info)

Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. (3/13)

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.  (+info)

Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma. (4/13)

Estimation of xenobiotic kinetics in humans frequently relies upon extrapolation from experimental data generated in animals. In an accompanying paper, we have presented a unique, generic, physiologically based pharmacokinetic model and described its application to the prediction of rat plasma pharmacokinetics from in vitro data alone. Here we demonstrate the application of the same model, parameterized for human physiology, to the estimation of plasma pharmacokinetics in humans and report a comparative evaluation against some recently published predictive methods that involve scaling from in vivo animal data. The model was parameterized through an optimization process, using a training set of in vivo data taken from the literature, and validated using a separate test set of published in vivo data. On average, the vertical divergence of the predicted plasma concentrations from the observed data, on a semilog concentration-time plot, was 0.47 log unit. For the training set, more than 80% of the predicted values of a standardized measure of the area under the concentration-time curve were within 3-fold of the observed values; over 70% of the test set predictions were within the same margin. Furthermore, in terms of predicting human clearance for the test set, the model was found to match or exceed the performance of three published interspecies scaling methods, all of which showed a distinct bias toward overprediction. We conclude that the generic physiologically based pharmacokinetic model, as a means of integrating readily determined in vitro and/or in silico data, is potentially a powerful, cost-effective tool for predicting human xenobiotic kinetics in drug discovery and risk assessment.  (+info)

Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. (5/13)

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More-sensitive enzyme-multiplied immunoassay technique for procainamide and N-acetylprocainamide in plasma, serum, and urine. (6/13)

A commercially available (Syva Co.) enzyme-multiplied immunoassay technique (EMIT) for the quantitative determination of procainamide (PA) and N-acetylprocainamide (NAPA) was modified to allow automated quantitative analysis of approximately 100 samples per day, in a working range of 0.1 to 2.0 micrograms/mL. Such a test was needed to evaluate the pharmacokinetic characteristics of controlled-release dosage forms characterized by long half-lives at low plasma concentration. Analytical recovery of PA and NAPA from serum, plasma, and urine was satisfactory, but at extreme ratios for PA:NAPA the accuracy of determining the lower-concentration component became unsatisfactory. In fact, however, we found no such ratios in 5400 clinical samples assayed by this procedure.  (+info)

Metabolites of procainamide and practolol inhibit complement components C3 and C4. (7/13)

Drug-induced systemic lupus erythematosus arises from toxic side-effects of administration of hydralazine, isoniazid, procainamide and practolol. Hydralazine and isoniazid are nucleophilic drugs and inhibit the covalent binding reaction of complement components, C3 and C4, an effect likely to lead to deposition of immune complexes (a feature of systemic lupus erythematosus). Procainamide and practolol do not themselves inhibit C3 and C4. A range of metabolites and putative metabolites of procainamide and practolol were synthesized, and tested for their ability to inhibit the covalent binding reactions of C3 and C4. The highly nucleophilic hydroxylamine metabolite of procainamide was strongly inhibitory in both tests, as was a putative hydroxylamine metabolite of practolol. These studies indicate a potential role for the hydroxylamine metabolites in mediating the toxic side-effects of procainamide and practolol, and emphasize the need for adequate measurements of hydroxylamine metabolites in human tissue.  (+info)

Four fluorescence polarization immunoassays for therapeutic drug monitoring evaluated. (8/13)

We evaluated four fluorescence polarization immunoassays--those for phenytoin, procainamide, N-acetylprocainamide (NAPA), and quinidine--from Roche Diagnostic Systems, done in the Cobas Bio FP centrifugal analyzer. The assays for phenytoin, NAPA, and quinidine demonstrated a linear response over the expected ranges of concentrations, and analytical recovery of test drug added to drug-free sera was greater than 90%. However, recovery in the procainamide assay was poor (69-82%) for samples containing greater than 8 mg/L, owing to nonlinearity. Results of method-comparison studies of the four assays paralleled the recovery studies, although the quinidine assay demonstrated a bias (1.0 mg/L higher) when compared with EMIT (Syva). The precision of the phenytoin assay was acceptable at all concentrations tested (total CV less than 7.0%). Imprecision of the other assays was significant at certain concentrations: total CV greater than 10.0% at subtherapeutic values for NAPA and quinidine, and greater than 9.0% for low (2.4 mg/L) and moderate concentrations (9.6 mg/L) of procainamide. Interferences were not significant for hemolyzed, icteric, or lipemic specimens or for specimens with added drug metabolites. The calibration curves for all four assays had good stability (greater than 60 days).  (+info)

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Acecainide (N-acetylprocainamide, NAPA) is an antiarrhythmic drug. Chemically, it is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug. It is only partially as active as procainamide; when checking levels, both must be included in the final calculation. In the early 1930s, Claude Beck was undertaking pioneer cardiac surgery at the Lakeside Hospital in Cleveland, Ohio. During and after his surgery he was facing problems with arrhythmias. These problems were investigated by Frederick R. Mautz. In these experiments he used drugs similar to cocaine, because these drugs were readily absorbed from mucous membranes and were also known to have some effect on the myocardium. Mautz tried procaine, but its action was short-lived owing to digestion by esterases. From procaine Mautz synthesized procainamide, which is not a substrate for esterases. Procainamide has the additional advantage of being active by mouth. ...
The objectives of this investigation were to characterize the disposition of fentanyl and alfentanil in 14 tissues in the rat, and to create physiological pharmacokinetic models for these opioids...
Prevacid coupons september 2012 the plant usually employs around 700 people, mostlyalgerians, and at the time of the siege bp had 20 people at theplant while statoil had 17! Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit hiv-1 ivermectin dosage for mange in dogs entry by targeting gp41. My time-consuming internet search has at the end of the day been paid with extremely good details to go over with my ivermectin pills for humans for sale neighbours. Evaluation based can humans use ivermectin for dogs on a physiological pharmacokinetic model. The length of follow-up in the rcts ranged from 6 months to a mean of 24 months. Ursolic acid inhibits stat3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Thanks a lot for giving ivermectin 12 mg tablet company name everyone an extremely remarkable opportunity to discover important secrets from this web site.. Core gross margin as a percentage buy ...
According to mathematical models of antiarrhythmic drug-receptor interactions, lidocaine binds preferentially to the sodium channel when the membrane is depolarized (i.e., the inactivated channel state). Therefore, the effect of lidocaine on conduction should be greater when the action potential duration is prolonged. To test this prediction in vivo we evaluated the rate-dependent effects of lidocaine on His-Purkinje conduction in the intact newborn canine heart. Lidocaines effect was assessed alone and then when given in combination with N-acetylprocainamide, a Class III antiarrhythmic agent. Utilizing intracardiac electrical stimulation and electrogram recording techniques, changes in the steady-state His-Purkinje conduction time during atrial pacing at increasingly rapid cycle lengths, changes in the conduction time of pacing trains delivered directly to the His bundle and changes in conduction time during His bundle extra stimulation were measured. After bilateral sectioning of the vagi ...
Our fluorescent westerns have components like transfer membranes with high protein binding capacity, protein free blockers and purified antibodies.
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Dyphylline is used to treat and/or prevent the symptoms of bronchial asthma, chronic bronchitis, and emphysema. It works by opening up the bronchial tubes (air passages of the lungs) and increasing the flow of air through them. ...
Core Lab offers an Agilent Bioanalyzer platform for a wide range of applications with its lab-on-a-chip technology, high resolution and quantification of RNA and DNA, and protein analysis. Those applications can be also supported by the NanoDrop One or Qubit spectrophotometers.. The recently acquired Odyssey CLx imaging system by Li-Core provides infrared imaging support for all Western Blots applications with Image Studio software.. Core Lab is equipped with a Microplate Absorbance reader - iMark by BioRad with a wavelength range of 400-750 nm; a high performance solution for various immunoassays with colorimetric substrates as well as various protein assays.. For all cell sorting needs Core Lab offers BioRad S3e fully automated cell sorter, with two lasers and up to four fluorescence detectors, plus forward- and side-scatter detectors.. Lastly, Core Lab offers a gel-imaging system - BioRads GelDoc EZ. This compact and automated gel imaging instrument enables production of publication-quality ...
XR11576 is an oral topoisomerase I and II inhibitor. The objectives of this phase I study were to assess the dose-limiting toxicities (DLTs), to determine the maximum tolerated dose (MTD) and to describe the pharmacokinetics (PKs) of XR11576 when administered orally on days 1-5 every 3 weeks to patients with advanced solid tumours. Patients were treated with escalating doses of XR11576 at doses ranging from 30 to 180 mg day -1. For PK analysis, plasma sampling was performed during the first and second courses of treatment and XR11576 concentrations were assayed using a validated high-performance liquid chromatographic assay with mass spectrometric detection. In all, 21 patients received a total of 47 courses. The MTD was reached at 180 mg day -1, with diarrhoea and fatigue as DLT. Nausea and vomiting, although not qualifying for DLT, was ubiquitous. Only in combination with an extensive prophylactic antiemetic regimen consisting of a combination of both dexamethasone and a 5HT3 antagonist was ...
Procainamide Antibody (PC12-416.1.1), MA1-10759, from Invitrogen™. Species Reactivity: Chemical; Applications: ELISA Shop Procainamide Mouse anti-Chemical, Clone: PC12-416.1.1,
Properties: Extremely bitter crystals from alcohol, mp 158°. uv max (0.001% in H2O): 273 nm (A1%1cm 361). Freely sol in water; one gram dissolves in 3 ml H2O at 25°. Soly (g/100 ml): alc 2; chloroform 1. pH (1% aq soln) 6.6 to 7.3. LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Altshuler). ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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51-06-9 - REQCZEXYDRLIBE-UHFFFAOYSA-N - Procainamide [INN:BAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly. This may cause serious, heart-related side effects. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects ...
Im doing some practice problems, and this is from nursesaregreat.com: A procainamide drip is ordered (2 gm in 250 cc of D5W) to infuse at 4mg/kg/min. The patient weighs 165 lbs. Calculate the
Laboratory Tests: False-positive tests for urine protein with MULTISTIX® may occur during therapy with Ranitidine Tablets, USP, and therefore testing with sulfosalicylic acid is recommended.. Drug Interactions: Ranitidine Tablets, USP have been reported to affect the bioavailability of other drugs through several different mechanisms such as competition for renal tubular secretion, alteration of gastric pH, and inhibition of cytochrome P450 enzymes.. Procainamide: Ranitidine, a substrate of the renal organic cation transport system, may affect the clearance of other drugs eliminated by this route. High doses of ranitidine (e.g., such as those used in the treatment of Zollinger-Ellison syndrome) have been shown to reduce the renal excretion of procainamide and N-acetylprocainamide resulting in increased plasma levels of these drugs. Although this interaction is unlikely to be clinically relevant at usual ranitidine doses, it may be prudent to monitor for procainamide toxicity when administered ...
Laboratory Tests: False-positive tests for urine protein with MULTISTIX® may occur during therapy with Ranitidine Tablets, USP, and therefore testing with sulfosalicylic acid is recommended.. Drug Interactions: Ranitidine Tablets, USP have been reported to affect the bioavailability of other drugs through several different mechanisms such as competition for renal tubular secretion, alteration of gastric pH, and inhibition of cytochrome P450 enzymes.. Procainamide: Ranitidine, a substrate of the renal organic cation transport system, may affect the clearance of other drugs eliminated by this route. High doses of ranitidine (e.g., such as those used in the treatment of Zollinger-Ellison syndrome) have been shown to reduce the renal excretion of procainamide and N-acetylprocainamide resulting in increased plasma levels of these drugs. Although this interaction is unlikely to be clinically relevant at usual ranitidine doses, it may be prudent to monitor for procainamide toxicity when administered ...
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123 medications are known to interact with dyphylline. Includes Astelin (azelastine nasal), Combivent (albuterol/ipratropium), Combivent Respimat (albuterol/ipratropium).
The IUPHAR/BPS Guide to Pharmacology. dyphylline ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
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Table 3: Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18 ...
BIOL 240. This course will familiarize students with physiological defence mechanisms against chemical and biological agents. It will build on previously taught biological principles and provide a foundation for future immunoassay techniques. Prerequisite: BIOL355. ...
1980 March; 17(3): 359-63. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=6903434 • Bacteriology of 100 consecutive diabetic foot infections and in vitro susceptibility to ampicillin/sulbactam versus cefoxitin. Author(s): Borrero E, Rossini M Jr. Source: Angiology. 1992 April; 43(4): 357-61. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=1558322 • Bacteriology of chronic sinusitis after ampicillin therapy. Author(s): Jiang RS, Hsu CY. Source: American Journal of Rhinology. 1997 November-December; 11(6): 467-71. Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=9571747 • High-performance liquid chromatographic assay of ampicillin and its prodrug lenampicillin. Author(s): Marzo A, Monti N, Ripamonti M, Arrigoni Martelli E, Picari M. Source: Journal of Chromatography. 1990 May 16; 507: 235-9. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2380291 • High-performance liquid chromatographic assay of ampicillin, amoxicillin and ciclacillin in serum and urine using a pre-column reaction with ...
Dyphylline is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Dyphylline and guaifenesin is a combination medicine used to treat cough and breathing...
123 medications are known to interact with Dyphylline GG. Includes Advair Diskus (fluticasone/salmeterol), Allergy Multi-Symptom (acetaminophen/chlorpheniramine/phenylephrine), benztropine.
lysine drug combination glycine acetylsalicylate: acelysin solution used in the treatment of acute purulent-inflammatory diseases of the soft tissues; 9:1 mixture of lysine acetylsalicylate and glycine
Harnessing the potential of cells as complex biosensors promises the potential to create sensitive and selective detectors for discrimination of biodefense agents. Here we present toxin detection and suggest discrimination using cells in a multianalyte microphysiometer (MMP) that is capable of simultaneously measuring flux changes in four extracellular analytes (acidification rate, glucose uptake, oxygen uptake, and lactate production) in real-time. Differential short-term cellular responses were observed between botulinum neurotoxin A and ricin toxin with neuroblastoma cells, alamethicin and anthrax protective antigen with RAW macrophages, and cholera toxin, muscarine, 2,4-dinitro-phenol, and NaF with CHO cells. These results and the post exposure dynamics and metabolic recovery observed in each case suggest the usefulness of cell-based detectors to discriminate between specific analytes and classes of compounds in a complex matrix, and furthermore to make metabolic inferences on the cellular effects
87 matching references were found. Niedz, R.P.; Moshonas, M.G.; Peterson, B.; Shapiro, J.P.; Shaw, P.E., Analysis of sweet orange (Citrus sinensis (L.) Osbeck) callus cultures for volatile compounds by gas chromatography with mass selective detector, Plant Cell Tissue Organ Cult., 1997, 51, 3, 181-185, https://doi.org/10.1023/A:1005977501472 . [all data] Peterson, B.H., Some binary systems with acetamide, Proc. Iowa Acad. Sci., 1943, 50, 253-9. [all data] Boozer, C.E.; Hammond, G.S.; Hamilton, C.E.; Peterson, C., Air Oxidation of Hydrocarbons IV. The Effects of Varying Solvent and the Mechanism of Uninhibited Chain Termination, J. Am. Chem. Soc., 1955, 77, 3380-3. [all data] Park, T.; Rettich, T.R.; Battino, R.; Peterson, D.; Wilhelm, E., Solubility of gases in liquids: 14. bunsen coefficients for several fluorine-containing gases (freons) dissolved in water at 298.15 k., J. Chem. Eng. Data, 1982, 27, 324-6. [all data] Peterson, D.A.; Schlie, L.A., Stable pure sulfur discharges and associated ...
Most states mandate that cannabis testing labs analyze samples for any fungal or microbial growth resulting from production or handling, as well as for mycotoxins, which are toxins produced by fungi. With the potential to become lethal, continuous exposure to mycotoxins can lead to a buildup of progressively worse allergic reactions.. LCMS should be used to qualify and identify strains of mycotoxins. However, determining the amount of microorganisms present is another challenge. That testing can be done using enzyme linked immunosorbent assay (ELISA), quantitative polymerase chain reaction (qPCR) or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), with each having their advantages and disadvantages.. For mycotoxin analysis, select a high-sensitivity LC-MS/MS instrument. In addition to standard LC, using an MS/MS selective detector enables labs to obtain limits of detection up to 1000 times greater than conventional LC-UV instruments.. For qPCR and its ...
Most states mandate that cannabis testing labs analyze samples for any fungal or microbial growth resulting from production or handling, as well as for mycotoxins, which are toxins produced by fungi. With the potential to become lethal, continuous exposure to mycotoxins can lead to a buildup of progressively worse allergic reactions.. LCMS should be used to qualify and identify strains of mycotoxins. However, determining the amount of microorganisms present is another challenge. That testing can be done using enzyme linked immunosorbent assay (ELISA), quantitative polymerase chain reaction (qPCR) or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), with each having their advantages and disadvantages.. For mycotoxin analysis, select a high-sensitivity LC-MS/MS instrument. In addition to standard LC, using an MS/MS selective detector enables labs to obtain limits of detection up to 1000 times greater than conventional LC-UV instruments.. For qPCR and its ...
To create a SEM image a focused primary electron beam scans across a sample surface. Due to the electron bombarding secondary electrons (SE) as well as backscattered electrons (BSE) emit from the sample.. While secondary elecontrons have an energy lower than 50 eV, backscattered electrons show much higher energies.The different electrons are therefore detected by two different, energy selective detectors which convert them into signals, amplifys and visualizes them on a monitor. The result is a tremendously vivid surface image. Since secondary electrons can only be emitted from the surface the resolution of the corresponding image is very good. It ranges between 5 and 10 nm. Backscattered electrons are generated at greater depths. Therefore, the resolution of the corresponding image is significantly lower. SEM have a field depth that is much higher than the one from optical microscopes.. ...
Enzyme multiplied immunoassay technique (EMIT) is a common method for qualitative and quantitative determination of therapeutic and recreational drugs and certain proteins in serum and urine. It is an immunoassay in which a drug or metabolite in the sample competes with an drug/metabolite labelled with an enzyme, to bind to an antibody. The more drug there is in the sample, the more free enzyme there will be, and the increased enzyme activity causes a change in color. Determination of drug levels in serum is particularly important when the difference in the concentrations needed to produce a therapeutic effect and adverse side reactions is small, the therapeutic window. EMIT therapeutic drug monitoring tests provide accurate information about the concentration of such drugs such as immunosuppressant drugs and some antibiotics. EMIT urine assays for drugs such as cannabinoids, morphine, and amphetamine are designed to detect the drug itself or a metabolite of the drug present in a concentration ...
Take this medicine by mouth. You can take it with or without food. If it upsets your stomach, take it with food. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctors advice.. Talk to your pediatrician regarding the use of this medicine in children. While some products may be prescribed for children as young as 6 years old for selected conditions, precautions do apply.. ...
Sprawdź ile zapłacisz za lek procainamide controlled-release w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
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We conclude that pure menthol and menthol in food or beverages have a similar systemic bioavailability and that menthol has a small cardioaccelerating effect.
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were kept at submicromolar concentrations by foam fractioning and biological filtration (e.g., live sand).. Variable Fluorescence. Variable chlorophyll fluorescence kinetic transients were measured with a custom-built fast repetition-rate fluorometer using protocols described by Kolber et al. (14).. Lipid Analysis. Lipids were saponified, methylated, and extracted into hexane/methyl tertiary butyl ether as described (15). Fatty acid methyl esters were analyzed by GC/MS with an Agilent series 6890 GC system and 5973 mass selective detector, equipped with an HP5MS capillary column (i.d., 30 m × 0.25 mm; film thickness, 0.25 μm) with helium as the carrier gas.. Membrane Inlet MS. Light-dependent production and consumption of oxygen was measured by using a membrane inlet system attached to a Prisma QMS-200 (Pfeiffer, Nashua, NH) quadruple mass spectrometer with closed ion source recording at mass/charge (m/z) ratios of 32 (16O16O), 36 (18O18O), and 40 (Ar). The membrane inlet system was modified ...
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Nearly 75% of patients receiving procainamide therapy will develop a positive ANA test within the first year of treatment, and over 90% develop a positive ANA
First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed
TY - JOUR. T1 - An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring dimension RxL Max clinical chemistry system. AU - Mendu, Damodara Rao. AU - Chou, Peter P.. AU - Soldin, Steven J.. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Caffeine is widely used in childrens hospitals to treat neonatal apnea. Amikacin is used for treating hospital-acquired infections caused by Gram-negative bacteria resistant to other aminoglycosides. The blood levels, however, have to be monitored carefully because of its ototoxicity and nephrotoxicity. Methotrexate (MTX) is used as a chemotherapeutic agent in the treatment of leukemia and lymphoma as well as of certain solid tumors. Current enzyme multiplied immunoassay technique (EMIT) assays for caffeine, amikacin, and MTX lack low-end precision. In addition, the EMIT assays for MTX lack the sensitivity of reliable quantification to 0.05 μmol/L needed because of todays more rigorous ...
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively characterized over the last three decades. However, the molecular mechanisms by which detergents influence membrane protein stability and function remain poorly understood, and elucidation of the dynamic detergent-lipid-protein interactions of solubilized membrane proteins is a largely unexplored research field. This study examined nine detergents upon nAChR solubilization and purification, to assess receptor lipid composition using GC (Gas Chromatography)-FID (Flame Ionization) and/or GC-MSD (Mass Selective Detectors), stability and aggregation state using A-SEC (Analytical Size-Exclusion Chromatography) and EM (Electron Microscopy), and planar lipid bilayers to measure ion channel function. Detergent solubilization of nAChR-enriched membranes did not result in significant native lipid depletion or destabilization. Upon purification, native lipid depletion occurred in all detergents, with lipid-analog ...
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively characterized over the last three decades. However, the molecular mechanisms by which detergents influence membrane protein stability and function remain poorly understood, and elucidation of the dynamic detergent-lipid-protein interactions of solubilized membrane proteins is a largely unexplored research field. This study examined nine detergents upon nAChR solubilization and purification, to assess receptor lipid composition using GC (Gas Chromatography)-FID (Flame Ionization) and/or GC-MSD (Mass Selective Detectors), stability and aggregation state using A-SEC (Analytical Size-Exclusion Chromatography) and EM (Electron Microscopy), and planar lipid bilayers to measure ion channel function. Detergent solubilization of nAChR-enriched membranes did not result in significant native lipid depletion or destabilization. Upon purification, native lipid depletion occurred in all detergents, with lipid-analog ...
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TY - JOUR. T1 - Correlation of pharmacokinetic indices with therapeutic outcome in patients receiving aminoglycosides. AU - Deziel-Evans, L. M.. AU - Murphy, J. E.. AU - Job, M. L.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - The influence of five pharmacokinetic indices on therapeutic response was retrospectively studied in 45 adult patients treated with aminoglycosides for bacterial infections. Subjects were treated for a minimum of five days, had culture and sensitivity reports, and had at least one set of steady-state peak and trough serum aminoglycoside concentrations. Serum drug concentrations were determined by enzyme-multiplied immunoassay or by fluorescence polarization assay. Minimum inhibitory concentrations (MICs) for the drugs were determined by microdilution assays. Cure was determined by negative cultures or absence of clinical evidence of infection. Values for five pharmacokinetic indices were determined for each patient: (1) ratio of steady-state peak serum concentration to MIC ...
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大部分心律不整都可以有效地治療[2],包括藥物治療、置放心律調節器以及手術。心搏過速的藥物包括乙型交感神經阻斷劑或抗心律不整藥物如普魯卡因胺(procainamide),而後者在長期使用有較顯著的副作用。心律調節器通常用在有症狀且藥物治療無效之心搏過緩病患。抗凝血劑用在某些心律不規則(如心房顫動)的病患以降低如中風等併發症的風險。危及生命的心律不整需要緊急進行電擊治療,包括整流(Cardioversion)及去顫兩種[6]。 第Ⅰ類:鈉離子通道阻斷劑 本類藥物抑制快速性鈉離子通道,降低心肌去極化動作電位變化速率(Vmax),即動作電位第0相,延長不反應期及動作電位期間(action potential duration; ...
Your condition will be monitored carefully while you are receiving this medicine.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more dizzy, increase flushing and rapid heartbeats. Avoid alcoholic drinks.. ...
While reports of ketamine abuse are increasing, reports of ketamine deaths and tissue concentrations associated with fatalities are rare. We report here a case of a mixed drug fatality involving ketamine and ethanol. Ketamine analysis was carried out by gas chromatography with a nitrogen-phosphorus …
... acecainide MeSH D02.241.223.100.054.055.105 - benzocaine MeSH D02.241.223.100.054.055.650 - procainamide MeSH D02.241.223.100. ...
... acecainide (INN) acecarbromal (INN) aceclidine (INN) aceclofenac (INN) acedapsone (INN) acediasulfone (INN) acedoben (INN) ...
... acecainide), an anti-arrhythmic heart drug NAPA Auto Parts, an American retailers' cooperative National Academy of Public ...
Some acecainide can convert to procainamide. The deacetylation clearance of acecainide is 0.39 L/h compare to a total NAPA ... acecainide can cause cardiac toxicity that effects in torsades de pointes. Also acecainide can decrease renal function when it ... Acecainide is considered comparable in activity to its parent compound; however, acecainide levels will vary widely. Serum ... However, hypotension has been reported in association with a rapid injection of acecainide. In animals, acecainide has positive ...
Some acecainide can convert to procainamide. The deacetylation clearance of acecainide is 0.39 L/h compare to a total NAPA ... acecainide can cause cardiac toxicity that effects in torsades de pointes. Also acecainide can decrease renal function when it ... Acecainide is considered comparable in activity to its parent compound; however, acecainide levels will vary widely. Serum ... However, hypotension has been reported in association with a rapid injection of acecainide. In animals, acecainide has positive ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Detailed drug Information for Zmax. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Detailed drug Information for zolmitriptan Nasal. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
This medicine should be used only for problems being treated by your doctor or conditions listed in the package directions. Check with your doctor before using it for other problems, especially if you think that an infection may be present. This medicine should not be used to treat certain kinds of skin infections or serious problems, such as severe burns.. Read the package label very carefully to see if the product contains any alcohol. Alcohol is flammable and can catch on fire. Do not use any product containing alcohol near a fire or open flame, or while smoking. Also, do not smoke after applying one of these products until it has completely dried.. If you are using this medicine on your face, be very careful not to get it in your eyes, mouth, or nose. If you are using an aerosol or spray form of this medicine, do not spray it directly on your face. Instead, use your hand or an applicator (for example, a sterile gauze pad or a cotton swab) to apply the medicine.. For patients using butamben: ...
Acecainide Current Synonym true false 159396014 N-acetylprocainamide Current Synonym true false ...
It is very important that your doctor check your progress while you receive this medicine to allow for changes in your dose and help reduce any unwanted effects.. Do not stop receiving Haldol® suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.. This medicine may cause serious allergic reactions (eg, anaphylaxis, angioedema, dermatitis exfoliative), which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a cracks in the skin, loss of heat from the body, rash, itching, hoarseness, red, swollen skin, scaly skin, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.. Contact your doctor as soon as possible if you have chest pain or discomfort, a fast heartbeat, trouble with breathing, or fever and chills. These may be symptoms of a very serious problem with your heart.. This medicine may cause tardive dyskinesia (a movement ...
Acecainide [D02.455.426.559.389.127.085.033] * Aminohippuric Acids [D02.455.426.559.389.127.085.067] * Amisulpride [D02.455. ...
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Copyright© Thomas Jefferson University. All Rights Reserved.. The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff ...
flecainide, amiodarone, acecainide. Unit - 3: Introduction, classification, synthesis and SAR of old and new drugs: Part-III: ...
Detailed drug Information for APO-risperiDONE. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Detailed drug Information for Foscavir. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Define acebutolol. Acebutolol as a noun means A beta-blocker drug, C|sub|18|/sub| H|sub|28|/sub| N|sub|2|/sub| O|sub|4|/sub| , used in its hydrochloride form to treat....
Bugaev N, Bhattacharya B, Chiu WC, Como JJ, Cripps MW, Ferrada P, Gelbard RB, Gondek S, Kasotakis G, Kim D, Mentzer C, Robinson BRH, Salcedo ES, Yeh DD. Promotility agents for the treatment of ileus in adult surgical patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 10; 87(4):922-934 ...
Detailed drug Information for buprenorphine Injection. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ...
Acecainide / therapeutic use Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Description of the drug vardenafil. - patient information, description, dosage and directions. What is vardenafil!
Acecainide,create,22-AUG-08,(null),(null) C75126,Acecainide_Hydrochloride,create,22-AUG-08,(null),(null) C75127,Ciprafamide, ...
Acecainide Hydrochloride Narrower Concept UI. M0000194. Registry Number. B9K738KX14. Terms. Acecainide Hydrochloride Preferred ... Acecainide Hydrochloride Acecainide Monohydrochloride Acetylprocainamide N-Acetylprocainamide Pharm Action. Anti-Arrhythmia ... Acecainide Preferred Term Term UI T000367. Date01/01/1999. LexicalTag NON. ThesaurusID ... Acecainide Preferred Concept UI. M0000193. Registry Number. 910Q707V6F. Related Numbers. 32795-44-1. 34118-92-8. B9K738KX14. ...
Acecainide Hydrochloride Narrower Concept UI. M0000194. Registry Number. B9K738KX14. Terms. Acecainide Hydrochloride Preferred ... Acecainide Hydrochloride Acecainide Monohydrochloride Acetylprocainamide N-Acetylprocainamide Pharm Action. Anti-Arrhythmia ... Acecainide Preferred Term Term UI T000367. Date01/01/1999. LexicalTag NON. ThesaurusID ... Acecainide Preferred Concept UI. M0000193. Registry Number. 910Q707V6F. Related Numbers. 32795-44-1. 34118-92-8. B9K738KX14. ...
ACDs ACDS complex ace ACE aceanthrylene Ace bandage Ace bandages acebutolol acecainide acecainide hydrochloride acecainide ...
Harron DW, Brogden RN: Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and ... and for this reason is available as the class III antidysrhythmic acecainide.38 ...
This graph shows the total number of publications written about "Aminohippuric Acids" by people in this website by year, and whether "Aminohippuric Acids" was a major or minor topic of these publications ...
ANTI-ARRHYTHMIA AGENTS ACECAINIDE ANTI-ARRHYTHMIA AGENTS ACETYLDIGITOXINS ANTI-ARRHYTHMIA AGENTS ACETYLDIGOXINS ANTI-ARRHYTHMIA ... CARDIOVASCULAR AGENTS ACECAINIDE CARDIOVASCULAR AGENTS ACETYLCHOLINE CARDIOVASCULAR AGENTS ACETYLDIGITOXINS CARDIOVASCULAR ...
ACDs ACDS complex ace ACE aceanthrylene Ace bandage Ace bandages acebutolol acecainide acecainide hydrochloride acecainide ...
Acecainide. Azure B. Monteplase. Ambenonium Chloride. Tea. Dopamine. Ethopropazine. Hexacarbacholine Bromide. Tolnaftate. ...
This graph shows the total number of publications written about "DEET" by people in this website by year, and whether "DEET" was a major or minor topic of these publications ...

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