Hydrogen peroxide and coffee induce G:C-->T:A transversions in the lacI gene of catalase-defective Escherichia coli. (1/34)The mutagenicity of hydrogen peroxide (H2O2) was compared with that of coffee, a complex mixture which generates H2O2. An Escherichia coli strain defective in catalase activity (katG katE double mutant) and carrying a single copy mucAB (pRW144) plasmid was constructed to enhance the mutagenic response to oxidants. The ability of the mucAB genes to influence the type, frequency and distribution of H2O2-induced mutations was also investigated in isogenic bacteria lacking pRW144. Induced mutational spectra were characterized and compared with that of spontaneous mutagenesis. A total of 444 independent forward mutations affecting the first 210 bp of the lacI gene were identified by DNA sequence analysis. The spontaneous mutation spectrum showed no bias (P = 0.52) for substitutions at G:C base pairs. In contrast, in the H2O2-induced spectrum substitutions occurred preferentially at G:C base pairs (P < 0.0001) with a preponderance of G:C-->T:A transversions (43.4% of H2O2-induced mutants versus 17.3% of spontaneous mutants). These data support the view that 7,8-dihydro-8-oxoguanine is the main premutagenic lesion induced by H2O2 and that catalase-defective bacteria have elevated levels of 8-oxoguanine in chromosome DNA after H2O2 exposure. Coffee produced a similar distribution of mutational events as H2O2 (P > 0.05), suggesting that this compound may be the main cause of the coffee-induced mutagenesis. The presence of plasmid pRW144 did not affect the frequency of H2O2-induced G:C-->T:A transversions, but caused an increase in A:T-->T:A transversions and a decrease in -1 base frameshifts. Although the frequencies of G:C-->T:A transversions were similar in all three induced spectra (H2O2 and coffee +/- pRW144), differences were observed in location of mutations throughout the target gene. (+info)
Tissue and organ expression of catalase in acatalasemic beagle dogs. (2/34)Acatalasemic Beagle dogs which were maintained in our laboratories showed no sign of catalase activity at all in the erythrocytes, and glutathione peroxidase and superoxide dismutase were at normal levels. Immunoblotting analysis demonstrated that no catalase protein is detectable in their erythrocytes. On the other hand, catalase activity was detected in other tissues and organs, albeit at varying, lower levels than in normal dogs. Quantitative immunoblotting analysis consistently demonstrated that the catalase protein is expressed in the liver and kidneys of acatalasemic dogs in proportion to the activity in these organs. The catalase mRNA expressions in the blood, liver and kidneys in acatalasemic dogs were almost the same as those in normal dogs. These results suggested that catalytically normal catalase protein is translated from mRNA in the tissues and organs including erythrocytes, but in erythrocytes this enzyme protein is disposed of by an unknown mechanism. (+info)
cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant. (3/34)Mutant catalase cDNAs from the hypocatalasemic and acatalasemic mice were cloned and expressed in bacteria. A novel missense mutation, Asp (AAT) to Ser (AGT), was identified at amino acid position 439 of the hypocatalasemic catalase. Analysis of recombinant catalase mutants revealed that the mutation is responsible for the reduced activity of hypocatalasemic catalase and the unstable tetrameric structure of acatalasemic catalase was also suggested. (+info)
Characterization of hydrogen peroxide removal reaction by hemoglobin in the presence of reduced pyridine nucleotides. (4/34)Hydrogen peroxide removal rates by hemoglobin were enhanced in the presence of reduced pyridine nucleotides. The species which had the activity to oxidize pyridine nucleotides was purified from human blood and identified as hemoglobin A. Hydrogen peroxide removal rates by hemoglobin A without reduced pyridine nucleotides at 0.2 mM hydrogen peroxide were 0.87+/-0.11 micromol/s/g hemoglobin, and the removal rates using 0.2 mM NADH and NADPH were 2.02+/-0.20 and 1.96+/-0.31 micromol/s/g hemoglobin, respectively. We deduced that the removal reaction by hemoglobin included formations of methemoglobin and the ferryl radical and reduction of the latter with pyridine nucleotides. The hydrogen peroxide removal ability by hemoglobin was less than that by catalase but was larger than that by glutathione peroxidase-glutathione reductase system at 0.2 mM hydrogen peroxide. Under acatalasemic conditions, it was suggested that NAD(P)H were important factors to prevent the oxidative degradation of hemoglobin. (+info)
Properties of acatalasic cells growing in vitro. (5/34)Acatalasia, a disease due to homozygosity for a Mendelian gene, is characterized by the absence of the enzyme catalase from the tissues of the human body. Red cells from heterozygotes have enzyme activities about one-half normal. In this paper, the development of cell lines from skin biopsies on an affected homozygote, a heterozygote, and eight control patients is described. The cell type is the euploid "fibroblast." It was found that acatalasic cells lacked the enzyme, even after growing for many months in a medium rich in catalase. The control lines all had mean catalase activities double or more that of the heterozygous line. Selection experiments, in which the growth of cells exposed for 20 minutes to varying concentrations of hydrogen peroxide was measured, did not provide a system for preferentially eliminating acatalasic cells. Certain other experiments bearing on the enzymatic defect in this disease were performed. (+info)
Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction. (6/34)Tissue homeostasis is determined by the balance between oxidants and antioxidants. Catalase is an important antioxidant enzyme regulating the level of intracellular hydrogen peroxide and hydroxyl radicals. The effect of catalase deficiency on renal tubulointerstitial injury induced by unilateral ureteral obstruction (UUO) has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) compared with wild-type mice (C3H/AnLCs(a)Cs(a)). Complete UUO caused interstitial cell infiltration, tubular dilation and atrophy, and interstitial fibrosis with accumulation of type IV collagen in obstructed kidneys (OBK) of both mouse groups. However, the degree of injury showed a significant increase in OBK of acatalasemic mice compared with that of wild-type mice until day 7. The deposition of lipid peroxidation products including 4-hydroxy-2-hexenal, malondialdehyde, and 4-hydroxy-2-nonenal was severer in dilated tubules of acatalasemic OBK. Apoptosis in tubular epithelial cells significantly increased in acatalasemic OBK at day 4. Expression of caspase-9, a marker of mitochondrial pathway-derived apoptosis, increased in dilated tubules of acatalasemic mice. The level of catalase activity remained low in acatalasemic OBK until day 7 without compensatory upregulation of glutathione peroxidase activity. The data indicate that acatalasemia exacerbated oxidation of renal tissue and sensitized tubular epithelial cells to apoptosis in OBK of UUO. This study demonstrates that catalase deficiency enhanced tubulointerstitial injury and fibrosis in a murine model of UUO and thus supports the protective role of catalase in this model. (+info)
Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice. (7/34)The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs(b)Cs(b)) mouse of C3H strain are lower than those of the normal (C3H/AnLCs (a)Cs(a)) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver. (+info)
Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. (8/34)BACKGROUND: Reactive oxygen species are involved in many of the angiotensin II signalling pathways. We have thus investigated whether the angiotensin II type 1 (AT1) receptor antagonist, telmisartan, can inhibit the accelerated renal fibrosis and excess oxidative stress, which occurs after unilateral ureteral obstruction (UUO) in acatalasemic mice. METHODS: The effect of daily intraperitoneal injection of telmisartan (0.1-0.3 mg/kg body weight) on the renal tubulointerstitial injury induced by UUO has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs b Cs b) and wild-type mice (C3H/AnLCs a Cs a). We evaluated the systemic blood pressure of the mice on the seventh day. In addition, the tubulointerstitial expression of collagens type I and type IV, the p22-, p47- and p67-phox subunits of NADPH oxidase, 4-hydroxy-2-nonenal, and 4-hydroxy-2-hexenal lipid peroxidation products were assessed by immunohistochemistry. The level of apoptosis was determined by terminal deoxynucleotidyl transferase nick end-labelling analysis, while the mRNA level of the p22-, p47- and p67-phox subunits was quantified by real-time PCR. The renal content of each of the antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase was determined by specific assay. RESULTS: Obstructed kidneys from acatalasemic mice exhibited increased tubulointerstitial deposition in dilated tubules of collagens type I and IV, lipid peroxidation products, and the p22/p47/p67-phox subunits of NADPH oxidase. The level of the p22/p47/p67-phox subunit mRNA, and of apoptosis in tubular epithelial cells, was also increased compared with those from wild-type kidneys. Treatment with telmisartan attenuated all of the changes and prevented renal fibrosis in a dose-dependent manner; despite the low dose (0.1 mg/kg). The treatment did not lower the systemic blood pressure. The catalase activity remained low in acatalasemic obstructed kidneys without compensatory upregulation of glutathione peroxidase or superoxide dismutase activity; the level of neither anti-oxidant enzymes in obstructed kidneys was affected by telmisartan. CONCLUSIONS: The AT1 receptor antagonist telmisartan ameliorated renal fibrosis after UUO by inhibition of oxidative stress, even under acatalasemic conditions. (+info)
Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain. |...
The N-terminal sequence of a protein, originally described as an adhesin of Helicobacter pylori, was used in an oligonucleotide-based screening procedure of an H. pylori plasmid library in Escherichia coli. Five independent plasmid clones were isolated, all mapping to the same chromosomal region and encoding the H. pylori catalase. The gene, designated katA, comprises 1,518 nucleotides and encodes a putative protein of 505 amino acids with a predicted Mr of 58,599. A second open reading frame, orf2, encoding a putative 32,715-Da protein of unknown function, follows katA. The transcriptional start site of katA mRNA was determined, but no typical consensus promoter sequence was present. A potential binding site for the Fur protein is located upstream of katA. When introduced into the catalase-deficient E. coli double-mutant UM255, the cloned gene readily complemented E. coli for catalase activity. H. pylori KatA is highly homologous to catalases in both prokaryotes and eukaryotes, with the highest ...
Microorganisms Having Bad Smell Removal Activity of Organic Waste and Use Thereof - Patent application
1711699DNASaccharomyces exiguus 1ggccaagcgt tagttagcat ttatacgtga aactgcgaat ggctcattaa atcagttatc 60gtttatttga tagttccttt actacatggt ataactgtgg taattctaga gctaatacat 120gcttaaaatc tcgacctctg gaagagatgt atttattaga taaaaaatca atgtcttcgg 180actctttgat gattcataat aacttttcga atcgcatggc cttgtgctgg cgatggttca 240ttcaaatttc tgccctatca actttcgatg gtaggatagt ggcctaccat ggtttcaacg 300ggtaacgggg aataagggtt cgattccgga gagggagcct gagaaacggc taccacatcc 360aaggaaggca gcaggcgcgc aaattaccca atcctaattc acggaggtag tgacaataaa 420taacgatacc gggcccattc gggtcttgca tttggaatga gtactatgta aataccttac 480tgagcaatac tccgacgcca agtctgttgc cagcagccgc gaaaattcca gctccaatag 540cgtatattaa agttgttgca gttaaaaagc tcgtagatga actttgagtc tgtttggccg 600gcccgatttt tctccgtact ggcatcccaa gcggaccttt ccttctggct aaccttgggt 660ccttgtggcc cctggcgaac caggattttt actttgaaaa aattagagtg ttcaaagcag 720gcgtattgct cgaatatatt agcatggaat aatagaatag gacgtttggt tctattttgt 780tggtttctag gaccatcgta atgattaata gggacggtcg ggggcatcag tattcaaatg 840tcagaggtga ...
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The role of catalase in protecting erythrocytes against methemoglobin formation. - 岡山大学学術成果リポジトリ
Some mechanisms to reduce methemoglobin (metHb) formation for the maintenance of normal oxygen transport have been proposed. To study the role of catalase (EC 220.127.116.11), metHb formation in the hemolysate of normal and Japanese acatalasemic human subjects were examined spectrophotometrically. Significantly increased level of metHb was induced by potassium ferrocyanide in the hemolysate of acatalasemic subject. The addition of catalase reduced the metHb formation, while 3-amino-1,2,4-triazole (AT), a specific inhibitor of catalase-H2O2 compound I, increased it. These results obtained from human subjects were well consistent with those from mice and suggested that catalase plays a role in protecting erythrocytes against metHb formation.. ...
Prohibition TCE Vapor Degreasing Methlyene Chloride NMP Paint Coating: Manko, Gold, Katcher & Fox
Uses of NMP include many of the same uses stated above for methylene chloride. Consumer use of NMP in paint and coating removal is similar to commercial use, and consumer products containing NMP are the same as those used in many commercial settings. EPA has estimated that approximately 30,000 workers and 732,000 consumers annually are exposed to NMP during paint and coating removal activities.. As stated above, EPA has co-proposed two approaches to regulating NMP. Under one approach, similar to the approaches to TCE and methylene chloride, EPA proposes to prohibit the manufacturing, processing, and distribution in commerce of NMP for consumer and commercial paint and coating removal; require manufacturers, processors, and distributors of NMP to provide downstream notification of the prohibitions; and require recordkeeping relevant to these prohibitions. The proposed rule would grant an exemption for specific military uses for which there are no technically feasible alternatives currently ...
Severe Weather Preparedness & Emergency Debris Management
If your locality does not have a debris management plan when disaster strikes, use DEQs Debris Management Planning Job Aid to help you answer key questions in order to initiate debris removal activities. This job aid is not intended to replace the more thorough planning process required to develop a formal debris management plan, but is instead for your use during real-time disaster response and recovery situations. Local governments with approved Debris Management Plans in place prior to incidents requiring debris removal could receive higher reimbursement rates through FEMA Public Assistance programs.. If your locality intends to manage storm-related solid wastes (such as household waste, white goods, construction/demolition debris, etc.) at a temporary debris management site, then you will need to obtain an emergency permit from DEQ. An emergency permit is not necessary for sites that will only manage vegetative waste (such as trees, branches, shrubs, leaves, stumps, roots, and other clean ...
Effects of Temperature on Catalase Activity | Education Index
Effects of Temperature and pH on Catalase Activity INTRODUCTION Enzymes are organic catalysts that spur metabolic reactions. The presence of an enzyme within...
Medizin: Asyl. Klinisches W rterbuch von Otto Dornbl th. Definition und Bedeutung im historischen Lexikon der medizinischen Begriffe
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Kit VitiDerm® Topical gel + Softgels - Vitiderm.fr
Vitiligo is characterized by a catalase deficiency that leads to the vacuolization of the melanocytes and keratinocytes. VitiDerm® is an innovative product from DermoPro. Oxidative stress and depigmentation Due to oxidative stress (high concentrations of free radicals) vacuolization and cell death occur.These include a gradual loss of melanocytes(1)(2)(3)(4) and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.(5)Keratinocytes in vitiligo lesions have proinflammatory responses, which can be inhibited through the combination of SOD and Catalase. Concentration of hydrogen peroxide (H2O2) in vitiligo patients Concentration of hydrogen peroxide (H2O2) in patients with vitiligo (red) compared to patients without vitiligo (blue)(9) Numerous recent studies have pinpointed certain anomalies in patients with skin depigmentation. In patients with vitiligo, it has been shown that a deficiency in catalase,
Catalase小鼠单克隆抗体[1A1](ab16771)可与小鼠, 大鼠, 人样本反应并经IP, ELISA, Flow Cyt, ICC/IF实验严格验证，被3篇文献引用并得到1个独立的用户反馈。
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Influence of microbial interactions and EPS/polysaccharide composition on nutrient removal activity in biofilms formed by...
The study of biofilm function, structure and microbial interactions might help to improve our understanding of biofilm wastewater treatment processes. However, few reports specifically address the influence of interactions within multispecies biofilms on microbial activity and biofilm composition. Thus, the relationship between biofilm formation, denitrification activity, phosphorus removal and the composition of extracellular polymeric substances (EPS), exopolysaccharides and the bacterial community was investigated using biofilms of denitrifying and phosphorus removing strains Comamonas denitrificans 110, Brachymonas denitrificans B79, Aeromonas hydrophila L6 and Acinetobacter calcoaceticus ATCC23055. Denitrification activity within the biofilms generally increased with the amount of biofilm while phosphorus removal depended on bacterial growth rate. Synergistic effects of co-growth on denitrification (B. denitrificans B79 and A. hydrophila L6) and phosphorus removal (C. denitrificans 110 with ...
Testing Catalase Activity (Gas Pressure) | Experiment #6B from Investigating Biology through Inquiry | Vernier
BIO-I #6B: In this Preliminary Activity, you will use catalase in yeast to catalytically decompose hydrogen peroxide. You will use an O2 Gas Sensor to determine the rate of catalase activity by measuring oxygen gas produced as H2O2 is decomposed. Before data collection begins, there is no product, and the pressure is the same as atmospheric pressure. Shortly after data collection begins, oxygen accumulates at a rather constant rate. The slope of the curve at this initial time is constant and is called the initial rate. In this investigation, we will refer to this as the rate of catalase activity. As the peroxide is decomposed, less of it is available to react and the O2 is produced at lower rates. When no more peroxide is left, O2 is no longer produced. When data collection is complete, you will perform a linear fit on the resultant graph to determine catalase activity. After completing the Preliminary Activity, you will first use reference sources to find out more about catalase, enzymes
Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase:...
Pseudomonas aeruginosa is an obligate aerobe that is virtually ubiquitous in the environment. During aerobic respiration, the metabolism of dioxygen can lead to the production of reactive oxygen intermediates, one of which includes hydrogen peroxide. To counteract the potentially toxic effects of this compound, P. aeruginosa possesses two heme-containing catalases which detoxify hydrogen peroxide. In this study, we have cloned katB, encoding one catalase gene of P. aeruginosa. The gene was cloned on a 5.4-kb EcoRI fragment and is composed of 1,539 bp, encoding 513 amino acids. The amino acid sequence of the P. aeruginosa katB was approximately 65% identical to that of a catalase from a related species, Pseudomonas syringae. The katB gene was mapped to the 71- to 75-min region of the P. aeruginosa chromosome, the identical region which harbors both sodA and sodB genes encoding both manganese and iron superoxide dismutases. When cloned into a catalase-deficient mutant of Escherichia coli (UM255), ...
Addgene: AdEasier-1 cells (strain)
Plasmid AdEasier-1 cells (strain) from Dr. Bert Vogelsteins lab contains the insert AdEasier-1 bacterial cells and is published in Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. This plasmid is available through Addgene.
Leaving Cert Biology Notes - leavingcertbiology.net
Students in 5th year managed to get very nice results in their experiment to determine the optimum pH for celery catalase activity ...
How Temperature Affects Catalase Activity. - GCSE Science - Marked by Teachers.com
Introduction. How Temperature Affects Catalase Activity. Aim: In this experiment I aim to investigate how altering the temperature exposed to the yeast catalase and the hydrogen peroxide, will affect the reaction and the gas product produced. Scientific background knowledge lets us know that there are 6 variables that usually affect the rate of a reaction, and they are as follows: * Concentration of enzymes * Concentration of hydrogen peroxide * Temperature condition of reaction * Pressure condition of reaction * Physical state of solid substrate (e.g. surface area of particles) [Some material reproduced from Biology 1 endorsed by OCR] In order to ensure fairness and accuracy, I will see to it that all the necessary and vital measurements are taken precise to the mark, and Ill aim to maintain all other latent variables constant. Hypothesis: Via my observation, I intend to prove that as the temperature of both the yeast catalase and the hydrogen peroxide id equally increased, the rate of which ...
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... is often the result of mutations in both copies of the CAT gene which codes for the enzyme catalase. There are ... Acatalasia is an autosomal recessive peroxisomal disorder caused by absent or very low levels of the enzyme catalase. Catalase ... Instead of a very bubbling reaction, blood turns brown-colored, which means the patient suffers from acatalasia.[citation ... Bissonnette, Bruno; Luginbuehl, Igor; Marciniak, Bruno; Dalens, Bernard J. (2006). "Acatalasia/Acatalasemia". Syndromes: Rapid ...
Acatalasia is a condition caused by homozygous mutations in CAT, resulting in a lack of catalase. Symptoms are mild and include ... Some humans have very low levels of catalase (acatalasia), yet show few ill effects. The increased oxidative stress that occurs ...
Antioxidative stress Acatalasia Bruce Ames Malondialdehyde, an oxidative stress marker Mitochondrial free radical theory of ...
Kawasaki Medical School
Takahara Shigeo - One‐time Professor who discovered Acatalasia Official site Official site (in Japanese) Medical Museum ...
List of skin conditions
Acatalasia (acatalasemia, Takahara's disease) Acquired dyskeratotic leukoplakia Actinic cheilitis (actinic cheilosis) Acute ...
List of MeSH codes (C18)
... acatalasia MeSH C18.452.648.556.750.112 - adrenoleukodystrophy MeSH C18.452.648.556.750.200 - chondrodysplasia punctata, ...
List of MeSH codes (C16)
... acatalasia MeSH C16.320.565.556.750.112 - adrenoleukodystrophy MeSH C16.320.565.556.750.200 - chondrodysplasia punctata, ...
Acatalasemia: MedlinePlus Genetics
DeCS 2016 - June 12, 2016 version
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DeCS - Términos Nuevos
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Metabolic Diseases, Disorders, and Health Challenges < Nutritional and Metabolic Diseases << Diseases <<< Sick Care Systems ...
Hydrogen peroxide 3% - 100ml | ADVA
Peroxisomal Disorders - Peroxisomal Disorder Summary Report | CureHunter
acataphasia | Taber's Medical Dictionary
Category:Autosomal recessive disorders - HandWiki
- should not be used by people with the genetic defect acatalasia! (bioadva.com)