Acatalasia: A rare autosomal recessive disorder resulting from the absence of CATALASE activity. Though usually asymptomatic, a syndrome of oral ulcerations and gangrene may be present.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Catalase: An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.Chloramphenicol O-Acetyltransferase: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Cat Diseases: Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Luminol: 5-Amino-2,3-dihydro-1,4-phthalazinedione. Substance that emits light on oxidation. It is used in chemical determinations.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.Sodium Hypochlorite: It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed)Erythrocyte Aging: The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Insurance Claim Review: Review of claims by insurance companies to determine liability and amount of payment for various services. The review may also include determination of eligibility of the claimant or beneficiary or of the provider of the benefit; determination that the benefit is covered or not payable under another policy; or determination that the service was necessary and of reasonable cost and quality.United StatesInsurance Claim Reporting: The design, completion, and filing of forms with the insurer.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Hajdu-Cheney Syndrome: Rare, autosomal dominant syndrome characterized by ACRO-OSTEOLYSIS, generalized OSTEOPOROSIS, and skull deformations.Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.Exfoliation Syndrome: The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)Tooth Exfoliation: Physiologic loss of the primary dentition. (Zwemer, Boucher's Clinical Dental Terminology, 4th ed)Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)Cherubism: A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.Leukocyte-Adhesion Deficiency Syndrome: Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.Perches: A common name for fish of the family Percidae, belonging to the suborder Percoidei, order PERCIFORMES.Cat's Claw: A vine (Uncaria tomentosa) indigenous to the Amazon rainforest whose name is derived from its hook-like thorns. It contains oxindole alkaloids and glycosides and has many medicinal uses.Togaviridae: A family of RNA viruses, mainly arboviruses, consisting of two genera: ALPHAVIRUS (group A arboviruses), and RUBIVIRUS. Virions are spherical, 60-70 nm in diameter, with a lipoprotein envelope tightly applied to the icosahedral nucleocapsid.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Hedgehog Proteins: A family of intercellular signaling proteins that play and important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.Veratrum Alkaloids: Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.Colubridae: The largest family of snakes, comprising five subfamilies: Colubrinae, Natricinae, Homalopsinae, Lycodontinae, and Xenodontinae. They show a great diversity of eating habits, some eating almost anything, others having a specialized diet. They can be oviparous, ovoviviparous, or viviparous. The majority of North American snakes are colubrines. Among the colubrids are king snakes, water moccasins, water snakes, and garter snakes. Some genera are poisonous. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp321-29)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Surgical Mesh: Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.Polypropylenes: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.Health Resources: Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.Knowledge: The body of truths or facts accumulated in the course of time, the cumulated sum of information, its volume and nature, in any civilization, period, or country.Medical Subject Headings: Controlled vocabulary thesaurus produced by the NATIONAL LIBRARY OF MEDICINE. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity.BoliviaBiotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.EcuadorAntibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Incontinentia Pigmenti: A genodermatosis occurring mostly in females and characterized by skin changes in three phases - vesiculobullous, verrucous papillomatous, and macular melanodermic. Hyperpigmentation is bizarre and irregular. Sixty percent of patients have abnormalities of eyes, teeth, central nervous system, and skin appendages.Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).Familial Hypophosphatemic Rickets: A hereditary disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. Autosomal and X-linked dominant and recessive variants have been reported.Hypophosphatemia, Familial: An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.PHEX Phosphate Regulating Neutral Endopeptidase: A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.Aicardi Syndrome: A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Hydrogen peroxide and coffee induce G:C-->T:A transversions in the lacI gene of catalase-defective Escherichia coli. (1/34)

The mutagenicity of hydrogen peroxide (H2O2) was compared with that of coffee, a complex mixture which generates H2O2. An Escherichia coli strain defective in catalase activity (katG katE double mutant) and carrying a single copy mucAB (pRW144) plasmid was constructed to enhance the mutagenic response to oxidants. The ability of the mucAB genes to influence the type, frequency and distribution of H2O2-induced mutations was also investigated in isogenic bacteria lacking pRW144. Induced mutational spectra were characterized and compared with that of spontaneous mutagenesis. A total of 444 independent forward mutations affecting the first 210 bp of the lacI gene were identified by DNA sequence analysis. The spontaneous mutation spectrum showed no bias (P = 0.52) for substitutions at G:C base pairs. In contrast, in the H2O2-induced spectrum substitutions occurred preferentially at G:C base pairs (P < 0.0001) with a preponderance of G:C-->T:A transversions (43.4% of H2O2-induced mutants versus 17.3% of spontaneous mutants). These data support the view that 7,8-dihydro-8-oxoguanine is the main premutagenic lesion induced by H2O2 and that catalase-defective bacteria have elevated levels of 8-oxoguanine in chromosome DNA after H2O2 exposure. Coffee produced a similar distribution of mutational events as H2O2 (P > 0.05), suggesting that this compound may be the main cause of the coffee-induced mutagenesis. The presence of plasmid pRW144 did not affect the frequency of H2O2-induced G:C-->T:A transversions, but caused an increase in A:T-->T:A transversions and a decrease in -1 base frameshifts. Although the frequencies of G:C-->T:A transversions were similar in all three induced spectra (H2O2 and coffee +/- pRW144), differences were observed in location of mutations throughout the target gene.  (+info)

Tissue and organ expression of catalase in acatalasemic beagle dogs. (2/34)

Acatalasemic Beagle dogs which were maintained in our laboratories showed no sign of catalase activity at all in the erythrocytes, and glutathione peroxidase and superoxide dismutase were at normal levels. Immunoblotting analysis demonstrated that no catalase protein is detectable in their erythrocytes. On the other hand, catalase activity was detected in other tissues and organs, albeit at varying, lower levels than in normal dogs. Quantitative immunoblotting analysis consistently demonstrated that the catalase protein is expressed in the liver and kidneys of acatalasemic dogs in proportion to the activity in these organs. The catalase mRNA expressions in the blood, liver and kidneys in acatalasemic dogs were almost the same as those in normal dogs. These results suggested that catalytically normal catalase protein is translated from mRNA in the tissues and organs including erythrocytes, but in erythrocytes this enzyme protein is disposed of by an unknown mechanism.  (+info)

cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant. (3/34)

Mutant catalase cDNAs from the hypocatalasemic and acatalasemic mice were cloned and expressed in bacteria. A novel missense mutation, Asp (AAT) to Ser (AGT), was identified at amino acid position 439 of the hypocatalasemic catalase. Analysis of recombinant catalase mutants revealed that the mutation is responsible for the reduced activity of hypocatalasemic catalase and the unstable tetrameric structure of acatalasemic catalase was also suggested.  (+info)

Characterization of hydrogen peroxide removal reaction by hemoglobin in the presence of reduced pyridine nucleotides. (4/34)

Hydrogen peroxide removal rates by hemoglobin were enhanced in the presence of reduced pyridine nucleotides. The species which had the activity to oxidize pyridine nucleotides was purified from human blood and identified as hemoglobin A. Hydrogen peroxide removal rates by hemoglobin A without reduced pyridine nucleotides at 0.2 mM hydrogen peroxide were 0.87+/-0.11 micromol/s/g hemoglobin, and the removal rates using 0.2 mM NADH and NADPH were 2.02+/-0.20 and 1.96+/-0.31 micromol/s/g hemoglobin, respectively. We deduced that the removal reaction by hemoglobin included formations of methemoglobin and the ferryl radical and reduction of the latter with pyridine nucleotides. The hydrogen peroxide removal ability by hemoglobin was less than that by catalase but was larger than that by glutathione peroxidase-glutathione reductase system at 0.2 mM hydrogen peroxide. Under acatalasemic conditions, it was suggested that NAD(P)H were important factors to prevent the oxidative degradation of hemoglobin.  (+info)

Properties of acatalasic cells growing in vitro. (5/34)

Acatalasia, a disease due to homozygosity for a Mendelian gene, is characterized by the absence of the enzyme catalase from the tissues of the human body. Red cells from heterozygotes have enzyme activities about one-half normal. In this paper, the development of cell lines from skin biopsies on an affected homozygote, a heterozygote, and eight control patients is described. The cell type is the euploid "fibroblast." It was found that acatalasic cells lacked the enzyme, even after growing for many months in a medium rich in catalase. The control lines all had mean catalase activities double or more that of the heterozygous line. Selection experiments, in which the growth of cells exposed for 20 minutes to varying concentrations of hydrogen peroxide was measured, did not provide a system for preferentially eliminating acatalasic cells. Certain other experiments bearing on the enzymatic defect in this disease were performed.  (+info)

Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction. (6/34)

Tissue homeostasis is determined by the balance between oxidants and antioxidants. Catalase is an important antioxidant enzyme regulating the level of intracellular hydrogen peroxide and hydroxyl radicals. The effect of catalase deficiency on renal tubulointerstitial injury induced by unilateral ureteral obstruction (UUO) has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) compared with wild-type mice (C3H/AnLCs(a)Cs(a)). Complete UUO caused interstitial cell infiltration, tubular dilation and atrophy, and interstitial fibrosis with accumulation of type IV collagen in obstructed kidneys (OBK) of both mouse groups. However, the degree of injury showed a significant increase in OBK of acatalasemic mice compared with that of wild-type mice until day 7. The deposition of lipid peroxidation products including 4-hydroxy-2-hexenal, malondialdehyde, and 4-hydroxy-2-nonenal was severer in dilated tubules of acatalasemic OBK. Apoptosis in tubular epithelial cells significantly increased in acatalasemic OBK at day 4. Expression of caspase-9, a marker of mitochondrial pathway-derived apoptosis, increased in dilated tubules of acatalasemic mice. The level of catalase activity remained low in acatalasemic OBK until day 7 without compensatory upregulation of glutathione peroxidase activity. The data indicate that acatalasemia exacerbated oxidation of renal tissue and sensitized tubular epithelial cells to apoptosis in OBK of UUO. This study demonstrates that catalase deficiency enhanced tubulointerstitial injury and fibrosis in a murine model of UUO and thus supports the protective role of catalase in this model.  (+info)

Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice. (7/34)

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs(b)Cs(b)) mouse of C3H strain are lower than those of the normal (C3H/AnLCs (a)Cs(a)) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.  (+info)

Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. (8/34)

BACKGROUND: Reactive oxygen species are involved in many of the angiotensin II signalling pathways. We have thus investigated whether the angiotensin II type 1 (AT1) receptor antagonist, telmisartan, can inhibit the accelerated renal fibrosis and excess oxidative stress, which occurs after unilateral ureteral obstruction (UUO) in acatalasemic mice. METHODS: The effect of daily intraperitoneal injection of telmisartan (0.1-0.3 mg/kg body weight) on the renal tubulointerstitial injury induced by UUO has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs b Cs b) and wild-type mice (C3H/AnLCs a Cs a). We evaluated the systemic blood pressure of the mice on the seventh day. In addition, the tubulointerstitial expression of collagens type I and type IV, the p22-, p47- and p67-phox subunits of NADPH oxidase, 4-hydroxy-2-nonenal, and 4-hydroxy-2-hexenal lipid peroxidation products were assessed by immunohistochemistry. The level of apoptosis was determined by terminal deoxynucleotidyl transferase nick end-labelling analysis, while the mRNA level of the p22-, p47- and p67-phox subunits was quantified by real-time PCR. The renal content of each of the antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase was determined by specific assay. RESULTS: Obstructed kidneys from acatalasemic mice exhibited increased tubulointerstitial deposition in dilated tubules of collagens type I and IV, lipid peroxidation products, and the p22/p47/p67-phox subunits of NADPH oxidase. The level of the p22/p47/p67-phox subunit mRNA, and of apoptosis in tubular epithelial cells, was also increased compared with those from wild-type kidneys. Treatment with telmisartan attenuated all of the changes and prevented renal fibrosis in a dose-dependent manner; despite the low dose (0.1 mg/kg). The treatment did not lower the systemic blood pressure. The catalase activity remained low in acatalasemic obstructed kidneys without compensatory upregulation of glutathione peroxidase or superoxide dismutase activity; the level of neither anti-oxidant enzymes in obstructed kidneys was affected by telmisartan. CONCLUSIONS: The AT1 receptor antagonist telmisartan ameliorated renal fibrosis after UUO by inhibition of oxidative stress, even under acatalasemic conditions.  (+info)

The N-terminal sequence of a protein, originally described as an adhesin of Helicobacter pylori, was used in an oligonucleotide-based screening procedure of an H. pylori plasmid library in Escherichia coli. Five independent plasmid clones were isolated, all mapping to the same chromosomal region and encoding the H. pylori catalase. The gene, designated katA, comprises 1,518 nucleotides and encodes a putative protein of 505 amino acids with a predicted Mr of 58,599. A second open reading frame, orf2, encoding a putative 32,715-Da protein of unknown function, follows katA. The transcriptional start site of katA mRNA was determined, but no typical consensus promoter sequence was present. A potential binding site for the Fur protein is located upstream of katA. When introduced into the catalase-deficient E. coli double-mutant UM255, the cloned gene readily complemented E. coli for catalase activity. H. pylori KatA is highly homologous to catalases in both prokaryotes and eukaryotes, with the highest ...
1711699DNASaccharomyces exiguus 1ggccaagcgt tagttagcat ttatacgtga aactgcgaat ggctcattaa atcagttatc 60gtttatttga tagttccttt actacatggt ataactgtgg taattctaga gctaatacat 120gcttaaaatc tcgacctctg gaagagatgt atttattaga taaaaaatca atgtcttcgg 180actctttgat gattcataat aacttttcga atcgcatggc cttgtgctgg cgatggttca 240ttcaaatttc tgccctatca actttcgatg gtaggatagt ggcctaccat ggtttcaacg 300ggtaacgggg aataagggtt cgattccgga gagggagcct gagaaacggc taccacatcc 360aaggaaggca gcaggcgcgc aaattaccca atcctaattc acggaggtag tgacaataaa 420taacgatacc gggcccattc gggtcttgca tttggaatga gtactatgta aataccttac 480tgagcaatac tccgacgcca agtctgttgc cagcagccgc gaaaattcca gctccaatag 540cgtatattaa agttgttgca gttaaaaagc tcgtagatga actttgagtc tgtttggccg 600gcccgatttt tctccgtact ggcatcccaa gcggaccttt ccttctggct aaccttgggt 660ccttgtggcc cctggcgaac caggattttt actttgaaaa aattagagtg ttcaaagcag 720gcgtattgct cgaatatatt agcatggaat aatagaatag gacgtttggt tctattttgt 780tggtttctag gaccatcgta atgattaata gggacggtcg ggggcatcag tattcaaatg 840tcagaggtga ...
Page 1 of 2 - Computer has slowed down and freezing more often and may be infected [ - posted in Virus, Spyware, Malware Removal: I dont know for sure that I have an infection but my computer seems to run slower than before. Some of the symptoms are difficulty doing simple tasks without freezing. I often have to restart the computer after a while of simple browsing. I think it needs a good cleaning. I have not attempted any removal activities recently. Thanks for any help. Scan resu...
Some mechanisms to reduce methemoglobin (metHb) formation for the maintenance of normal oxygen transport have been proposed. To study the role of catalase (EC 1.11.1.6), metHb formation in the hemolysate of normal and Japanese acatalasemic human subjects were examined spectrophotometrically. Significantly increased level of metHb was induced by potassium ferrocyanide in the hemolysate of acatalasemic subject. The addition of catalase reduced the metHb formation, while 3-amino-1,2,4-triazole (AT), a specific inhibitor of catalase-H2O2 compound I, increased it. These results obtained from human subjects were well consistent with those from mice and suggested that catalase plays a role in protecting erythrocytes against metHb formation.. ...
Uses of NMP include many of the same uses stated above for methylene chloride. Consumer use of NMP in paint and coating removal is similar to commercial use, and consumer products containing NMP are the same as those used in many commercial settings. EPA has estimated that approximately 30,000 workers and 732,000 consumers annually are exposed to NMP during paint and coating removal activities.. As stated above, EPA has co-proposed two approaches to regulating NMP. Under one approach, similar to the approaches to TCE and methylene chloride, EPA proposes to prohibit the manufacturing, processing, and distribution in commerce of NMP for consumer and commercial paint and coating removal; require manufacturers, processors, and distributors of NMP to provide downstream notification of the prohibitions; and require recordkeeping relevant to these prohibitions. The proposed rule would grant an exemption for specific military uses for which there are no technically feasible alternatives currently ...
If your locality does not have a debris management plan when disaster strikes, use DEQs Debris Management Planning Job Aid to help you answer key questions in order to initiate debris removal activities. This job aid is not intended to replace the more thorough planning process required to develop a formal debris management plan, but is instead for your use during real-time disaster response and recovery situations. Local governments with approved Debris Management Plans in place prior to incidents requiring debris removal could receive higher reimbursement rates through FEMA Public Assistance programs.. If your locality intends to manage storm-related solid wastes (such as household waste, white goods, construction/demolition debris, etc.) at a temporary debris management site, then you will need to obtain an emergency permit from DEQ. An emergency permit is not necessary for sites that will only manage vegetative waste (such as trees, branches, shrubs, leaves, stumps, roots, and other clean ...
Effects of Temperature and pH on Catalase Activity INTRODUCTION Enzymes are organic catalysts that spur metabolic reactions. The presence of an enzyme within...
... Klinisches W rterbuch von Otto Dornbl th. Definition und Bedeutung im historischen Lexikon der medizinischen Begriffe
With an ultra-swanky checkerboard-tiled lobby and 185 rooms done up in Raphaelite tones of jade, claret, and sapphire blue, the landmark Gramercy Park Hotel offers a taste of modern glamour.
Catalase小鼠单克隆抗体[1A1](ab16771)可与小鼠, 大鼠, 人样本反应并经IP, ELISA, Flow Cyt, ICC/IF实验严格验证,被3篇文献引用并得到1个独立的用户反馈。
Wake up your face with the ultimate concealer palette in six color correcting shades. NYX Professional Makeup 3C Conceal Correct Contour Palette is a lightweight, non-creasing formula which glides on for an ultra-smooth finish.
The study of biofilm function, structure and microbial interactions might help to improve our understanding of biofilm wastewater treatment processes. However, few reports specifically address the influence of interactions within multispecies biofilms on microbial activity and biofilm composition. Thus, the relationship between biofilm formation, denitrification activity, phosphorus removal and the composition of extracellular polymeric substances (EPS), exopolysaccharides and the bacterial community was investigated using biofilms of denitrifying and phosphorus removing strains Comamonas denitrificans 110, Brachymonas denitrificans B79, Aeromonas hydrophila L6 and Acinetobacter calcoaceticus ATCC23055. Denitrification activity within the biofilms generally increased with the amount of biofilm while phosphorus removal depended on bacterial growth rate. Synergistic effects of co-growth on denitrification (B. denitrificans B79 and A. hydrophila L6) and phosphorus removal (C. denitrificans 110 with ...
BIO-I #6B: In this Preliminary Activity, you will use catalase in yeast to catalytically decompose hydrogen peroxide. You will use an O2 Gas Sensor to determine the rate of catalase activity by measuring oxygen gas produced as H2O2 is decomposed. Before data collection begins, there is no product, and the pressure is the same as atmospheric pressure. Shortly after data collection begins, oxygen accumulates at a rather constant rate. The slope of the curve at this initial time is constant and is called the initial rate. In this investigation, we will refer to this as the rate of catalase activity. As the peroxide is decomposed, less of it is available to react and the O2 is produced at lower rates. When no more peroxide is left, O2 is no longer produced. When data collection is complete, you will perform a linear fit on the resultant graph to determine catalase activity. After completing the Preliminary Activity, you will first use reference sources to find out more about catalase, enzymes
Pseudomonas aeruginosa is an obligate aerobe that is virtually ubiquitous in the environment. During aerobic respiration, the metabolism of dioxygen can lead to the production of reactive oxygen intermediates, one of which includes hydrogen peroxide. To counteract the potentially toxic effects of this compound, P. aeruginosa possesses two heme-containing catalases which detoxify hydrogen peroxide. In this study, we have cloned katB, encoding one catalase gene of P. aeruginosa. The gene was cloned on a 5.4-kb EcoRI fragment and is composed of 1,539 bp, encoding 513 amino acids. The amino acid sequence of the P. aeruginosa katB was approximately 65% identical to that of a catalase from a related species, Pseudomonas syringae. The katB gene was mapped to the 71- to 75-min region of the P. aeruginosa chromosome, the identical region which harbors both sodA and sodB genes encoding both manganese and iron superoxide dismutases. When cloned into a catalase-deficient mutant of Escherichia coli (UM255), ...
Plasmid AdEasier-1 cells (strain) from Dr. Bert Vogelsteins lab contains the insert AdEasier-1 bacterial cells and is published in Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. This plasmid is available through Addgene.
Students in 5th year managed to get very nice results in their experiment to determine the optimum pH for celery catalase activity ...
Introduction. How Temperature Affects Catalase Activity. Aim: In this experiment I aim to investigate how altering the temperature exposed to the yeast catalase and the hydrogen peroxide, will affect the reaction and the gas product produced. Scientific background knowledge lets us know that there are 6 variables that usually affect the rate of a reaction, and they are as follows: * Concentration of enzymes * Concentration of hydrogen peroxide * Temperature condition of reaction * Pressure condition of reaction * Physical state of solid substrate (e.g. surface area of particles) [Some material reproduced from Biology 1 endorsed by OCR] In order to ensure fairness and accuracy, I will see to it that all the necessary and vital measurements are taken precise to the mark, and Ill aim to maintain all other latent variables constant. Hypothesis: Via my observation, I intend to prove that as the temperature of both the yeast catalase and the hydrogen peroxide id equally increased, the rate of which ...
Best Catalase Enzyme from Catalase Enzyme suppliers, quality Catalase Enzyme manufacturer from China alpha-amylaseenzyme of page 2.
Some humans have very low levels of catalase (acatalasia), yet show few ill effects. Catalase is usually located in a cellular ...
Reductive stress Acatalasia Antioxidant Bruce Ames Denham Harman Malondialdehyde, an oxidative stress marker Mitochondrial free ...
Takahara Shigeo - One‐time Professor who discovered Acatalasia Official site Official site (in Japanese) Medical Museum ...
... acatalasia MeSH C18.452.648.556.750.112 --- adrenoleukodystrophy MeSH C18.452.648.556.750.200 --- chondrodysplasia punctata, ...
... acatalasia MeSH C16.320.565.556.750.112 --- adrenoleukodystrophy MeSH C16.320.565.556.750.200 --- chondrodysplasia punctata, ...
Defects of catalase and peroxidase Acatalasia (Takahara) (E80.4) Gilbert's syndrome (E80.5) Crigler-Najjar syndrome (E80.6) ...
Acatalasia (acatalasemia, Takahara's disease) Acquired dyskeratotic leukoplakia Actinic cheilitis (actinic cheilosis) Acute ...
Occurrence of acatalasia is often the result of mutation in the CAT gene which codes for the enzyme catalase. Researchers ... Acatalasia (also called acatalasemia, or Takahara's disease) is an autosomal recessive peroxisomal disorder caused by low ...
Acatalasia. *Accelerated idioventricular rhythm. *Accelerated phase chronic myelogenous leukemia. *Accessory breast. *Accessory ...
Acatalasia. *RCP 2&3. *Mevalonate kinase deficiency. *D-bifunctional protein deficiency. *Adult Refsum disease-1 ...
Acatalasia. *RCP 2&3. *Mevalonate kinase deficiency. *D-bifunctional protein deficiency. *Adult Refsum disease-1 ...
Occurrence of acatalasia is often the result of mutation in the CAT gene which codes for the enzyme catalase. Researchers ... Acatalasia (also called acatalasemia, or Takaharas disease) is an autosomal recessive peroxisomal disorder caused by low ...
Find out information about acatalasia. Congenital absence of the enzyme catalase Explanation of acatalasia ... acatalasia. Also found in: Medical, Wikipedia. acatalasia. [¦ā·ka·tə′lā·zhē·ə or zhə] (medicine) Congenital absence of the ... Acatalasia , Article about acatalasia by The Free Dictionary https://encyclopedia2.thefreedictionary.com/acatalasia ... The absence of CAT in the blood and other tissues in the human body leads to the occurrence of acatalasia, which is manifested ...
... hypocatalasemia or acatalasia) is a rare inherited disorder that is caused by recessive mutation in the CAT gene which is ... The dog is likely to develop Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia and will pass the mutant gene to its ... Catalase Deficiency (hypocatalasemia or acatalasia) is a rare inherited disorder that is caused by recessive mutation in the ... It is very unlikely that the dog will develop Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia. The dog will never ...
... (also called acatalasemia, or Takaharas disease) is a deficiency of the enzyme catalase, is a relatively benign ... Factors of Acatalasia:. *Many patients with acatalasia are asymptomatic, while some develop mouth sores. Acatalasia ( ... Acatalasia. Definition: Acatalasia (also called acatalasemia, or Takaharas disease) is a deficiency of the enzyme catalase, is ... Acatalasia is often the result of mutations in both copies of the CAT gene which codes for the enzyme catalase. There are ...
"Acatalasia/Acatalasemia." Syndromes: Rapid Recognition and Perioperative Implications Bissonnette B, Luginbuehl I, Marciniak B ... Acatalasia/Acatalasemia. In: Bissonnette B, Luginbuehl I, Marciniak B, Dalens BJ. Bissonnette B, & Luginbuehl I, & Marciniak B ... Acatalasia/acatalasemia. Bissonnette B, Luginbuehl I, Marciniak B, Dalens BJ. Bissonnette B, & Luginbuehl I, & Marciniak B, & ... Acatalasia also has been detected in Switzerland and Israel. Swiss and Israeli homozygotes show some residual catalase activity ...
Semua informasi yang ada dalam situs ini hanya ditujukan untuk pengetahuan semata dan bukan sebagai pengganti dari saran maupun terapi yang diberikan oleh dokter dan atau tenaga medis lainnya. Informasi yang ada dalam Farmasi-id.com berasal dari berbagai sumber dan Farmasi-id.com tidak menjamin kebenaran dan atau kevalidan data dari setiap informasi yang ada. Farmasi-id.com tidak menjamin, baik secara tegas atau tersirat, mengenai kebenaran, ketepatan, kesesuaian berkenaan dengan situs web atau informasi yang tercantum di situs ini untuk segala tujuan. Farmasi-id.com tidak bertanggung jawab atas segala risiko baik langsung maupun tidak langsung yang timbul sebagai akibat dari penggunaan Informasi dalam situs ini. Oleh sebab itu, ketergantungan Anda pada informasi tersebut adalah atas risiko Anda sendiri ...
acatalasia. *catalase deficiency. Additional Information & Resources. Genetic Testing Information. *Genetic Testing Registry: ...
Some humans have very low levels of catalase (acatalasia), yet show few ill effects. Catalase is usually located in a cellular ...
acatalasia Relevant External Links for CAT. Genetic Association Database (GAD) CAT Human Genome Epidemiology (HuGE) Navigator ...
acatalasia, see Acatalasemia. *ACC, see Nonsyndromic aplasia cutis congenita. *ACCPN, see Andermann syndrome ...
Deficiency results in acatalasia. adj., adj catalat´ic.. cat·a·lase. (kată-lās), [MIM*115500] A hemoprotein catalyzing the ... genetic deficiency of the enzyme results in acatalasia.catalat´ic. catalase. (kăt′l-ās′, -āz′). n.. An enzyme found in living ...
Oxidative hemolysis and erythrocyte metabolism in hereditary acatalasia. J Clin Invest 1965;44:1187. ...
Acatalasia. 7 pages, 1846 words. Access Control Lists. 11 pages, 2959 words. ...
Acatalasia. 7 pages / 1846 words. Download. Access Control Lists. 10 pages / 2959 words ...
Acatalasia 277.89. *Christians syndrome (chronic histiocytosis X) 277.89. *Disease, diseased - see also Syndrome*. Christians ...
Hypophosphatasia, immunodeficiency, diabetes mellitus, hyperthyroidism, and acatalasia can be excluded with hematologic ... acatalasia, Singleton-Merten syndrome, Hajdu-Cheney syndrome, Coffin-Lowry syndrome, and Chediak-Higashi syndrome. ...
Japanese (Koreans) Acatalasia Autosomal recessive. Dsychromatosis universilas hereditaria Autosomal recessive. Oguchis disease ...
Catalase is encoded by the CAT gene, defects in CAT are the cause of acatalasia (ACATLAS), also known as acatalasemia. This ... Defects in CAT are the cause of acatalasia (ACATLAS) [MIM:115500]; also known as acatalasemia. This disease is characterized by ...
Defects in CAT are the cause of acatalasia (ACATLAS) [MIM:115500]; also known as acatalasemia. This disease is characterized by ...
Alpha 1-antitrypsin deficiency - Cystic fibrosis - Amyloidosis (Familial Mediterranean fever) - Acatalasia. Categories: ...
Alpha 1-antitrypsin deficiency - Cystic fibrosis - Amyloidosis (Familial Mediterranean fever) - Acatalasia. Categories: ...
Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia New Breed: Beagle. 1-2 weeks £ 40.00 + vat (£48.00 incl vat) ...
Acatalasia (or Takaharas disease) is a peroxisomal disorder caused by a catalase deficiency. ... For other uses, see Eye ( ...
PEDs are caused by a functional defect in one peroxisomal pathway and include metabolic syndromes such as acatalasia, Acyl-CoA ...
  • Defects in the gene encoding for the catalase protein can cause acatalasia, a disease characterized by the absence of catalase activity in red cells and associated with ulcerating oral lesions. (scbt.com)
  • The differential diagnosis includes angranulo- cytosis, cyclic neutropenia, aplastic anemia, Thalassemias leukemia, acatalasia, hypophosphatasia, juvenile Thalassemias are a group of disorders that result diabetes mellitus, Papillon-Lefevre syndrome from an inherited distortion of globin fusion. (bmfa.org)