Acarbose: An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.Trisaccharides: Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.alpha-Glucosidases: Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.Imino Pyranoses: Six-carbon pyranose sugars in which the OXYGEN is replaced by a NITROGEN atom.Hypoglycemic Agents: Substances which lower blood glucose levels.Glycogen Debranching Enzyme System: 1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrolase. An enzyme system having both 4-alpha-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33) activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or another 1,4-alpha-D-glucan. As a glucosidase it catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-1,6-glucosidase activity is deficient in glycogen storage disease type III.alpha-Amylases: Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.Postgastrectomy Syndromes: Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.Glucosidases: Enzymes that hydrolyze O-glucosyl-compounds. (Enzyme Nomenclature, 1992) EC 3.2.1.-.Glucan 1,4-alpha-Glucosidase: An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.Micromonosporaceae: A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.Maltose: A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
(1/145) Manganese sulfate-dependent glycosylation of endogenous glycoproteins in human skeletal muscle is catalyzed by a nonglucose 6-P-dependent glycogen synthase and not glycogenin.

Glycogenin, a Mn2+-dependent, self-glucosylating protein, is considered to catalyze the initial glucosyl transfer steps in glycogen biogenesis. To study the physiologic significance of this enzyme, measurements of glycogenin mediated glucose transfer to endogenous trichloroacetic acid precipitable material (protein-bound glycogen, i.e., glycoproteins) in human skeletal muscle were attempted. Although glycogenin protein was detected in muscle extracts, activity was not, even after exercise that resulted in marked glycogen depletion. Instead, a MnSO4-dependent glucose transfer to glycoproteins, inhibited by glycogen and UDP-pyridoxal (which do not affect glycogenin), and unaffected by CDP (a potent inhibitor of glycogenin), was consistently detected. MnSO4-dependent activity increased in concert with glycogen synthase fractional activity after prolonged exercise, and the MnSO4-dependent enzyme stimulated glucosylation of glycoproteins with molecular masses lower than those glucosylated by glucose 6-P-dependent glycogen synthase. Addition of purified glucose 6-P-dependent glycogen synthase to the muscle extract did not affect MnSO4-dependent glucose transfer, whereas glycogen synthase antibody completely abolished MnSO4-dependent activity. It is concluded that: (1) MnSO4-dependent glucose transfer to glycoproteins is catalyzed by a nonglucose 6-P-dependent form of glycogen synthase; (2) MnSO4-dependent glycogen synthase has a greater affinity for low molecular mass glycoproteins and may thus play a more important role than glucose 6-P-dependent glycogen synthase in the initial stages of glycogen biogenesis; and (3) glycogenin is generally inactive in human muscle in vivo.  (+info)

(2/145) Modes of action of acarbose hydrolysis and transglycosylation catalyzed by a thermostable maltogenic amylase, the gene for which was cloned from a Thermus strain.

A maltogenic amylase gene was cloned in Escherichia coli from a gram-negative thermophilic bacterium, Thermus strain IM6501. The gene encoded an enzyme (ThMA) with a molecular mass of 68 kDa which was expressed by the expression vector p6xHis119. The optimal temperature of ThMA was 60 degrees C, which was higher than those of other maltogenic amylases reported so far. Thermal inactivation kinetic analysis of ThMA indicated that it was stabilized in the presence of 10 mM EDTA. ThMA harbored both hydrolysis and transglycosylation activities. It hydrolyzed beta-cyclodextrin and starch mainly to maltose and pullulan to panose. ThMA not only hydrolyzed acarbose, an amylase inhibitor, to glucose and pseudotrisaccharide (PTS) but also transferred PTS to 17 sugar acceptors, including glucose, fructose, maltose, cellobiose, etc. Structural analysis of acarbose transfer products by using methylation, thin-layer chromatography, high-performance ion chromatography, and nuclear magnetic resonance indicated that PTS was transferred primarily to the C-6 of the acceptors and at lower degrees to the C-3 and/or C-4. The transglycosylation of sugar to methyl-alpha-D-glucopyranoside by forming an alpha-(1,3)-glycosidic linkage was demonstrated for the first time by using acarbose and ThMA. Kinetic analysis of the acarbose transfer products showed that the C-4 transfer product formed most rapidly but readily hydrolyzed, while the C-6 transfer product was stable and accumulated in the reaction mixture as the main product.  (+info)

(3/145) The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.

The putative biosynthetic gene cluster for the alpha-glucosidase inhibitor acarbose was identified in the producer Actinoplanes sp. 50/110 by cloning a DNA segment containing the conserved gene for dTDP-D-glucose 4,6-dehydratase, acbB. The two flanking genes were acbA (dTDP-D-glucose synthase) and acbC, encoding a protein with significant similarity to 3-dehydroquinate synthases (AroB proteins). The acbC gene was overexpressed heterologously in Streptomyces lividans 66, and the product was shown to be a C7-cyclitol synthase using sedo-heptulose 7-phosphate, but not ido-heptulose 7-phosphate, as its substrate. The cyclization product, 2-epi-5-epi-valiolone ((2S,3S,4S,5R)-5-(hydroxymethyl)cyclohexanon-2,3,4,5-tetrol), is a precursor of the valienamine moiety of acarbose. A possible five-step reaction mechanism is proposed for the cyclization reaction catalyzed by AcbC based on the recent analysis of the three-dimensional structure of a eukaryotic 3-dehydroquinate synthase domain (Carpenter, E. P., Hawkins, A. R., Frost, J. W., and Brown, K. A. (1998) Nature 394, 299-302).  (+info)

(4/145) Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli.

The pseudooligosaccharide acarbose is a potent inhibitor of amylases, glucosidases, and cyclodextrin glycosyltransferase and is clinically used for the treatment of so-called type II or insulin-independent diabetes. The compound consists of an unsaturated aminocyclitol, a deoxyhexose, and a maltose. The unsaturated aminocyclitol moiety (also called valienamine) is primarily responsible for the inhibition of glucosidases. Due to its structural similarity to maltotetraose, we have investigated whether acarbose is recognized as a substrate by the maltose/maltodextrin system of Escherichia coli. Acarbose at millimolar concentrations specifically affected the growth of E. coli K-12 on maltose as the sole source of carbon and energy. Uptake of radiolabeled maltose was competitively inhibited by acarbose, with a Ki of 1.1 microM. Maltose-grown cells transported radiolabeled acarbose, indicating that the compound is recognized as a substrate. Studying the interaction of acarbose with purified maltoporin in black lipid membranes revealed that the kinetics of acarbose binding to LamB is asymmetric. The on-rate of acarbose is approximately 30 times lower when the molecule enters the pore from the extracellular side than when it enters from the periplasmic side. Acarbose could not be utilized as a carbon source since the compound alone was not a substrate of amylomaltase (MalQ) and was only poorly attacked by maltodextrin glucosidase (MalZ).  (+info)

(5/145) A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)

OBJECTIVE: To determine the degree to which alpha-glucosidase inhibitors, with their unique mode of action primarily reducing postprandial hyperglycemia, offer an additional therapeutic approach in the long-term treatment of type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied 1,946 patients (63% men) who were previously enrolled in the U.K. Prospective Diabetes Study (UKPDS). The patients were randomized to acarbose (n = 973), titrating to a maximum dose of 100 mg three times per day, or to matching placebo (n = 973). Mean +/- SD age was 59 +/- 9 years, body weight 84 +/- 17 kg, diabetes duration 7.6 +/- 2.9 years, median (interquartile range) HbA1c 7.9% (6.7-9.5), and fasting plasma glucose (FPG) 8.7 mmol/l (6.8-11.1). Fourteen percent of patients were treated with diet alone, 52% with monotherapy, and 34% with combined therapy. Patients were monitored in UKPDS clinics every 4 months for 3 years. The main outcome measures were HbA1c, FPG, body weight, compliance with study medication, incidence of side effects, and frequency of major clinical events. RESULTS: At 3 years, a lower proportion of patients were taking acarbose compared with placebo (39 vs. 58%, P < 0.0001), the main reasons for noncompliance being flatulence (30 vs. 12%, P < 0.0001) and diarrhea (16 vs. 8%, P < 0.05). Analysis by intention to treat showed that patients allocated to acarbose, compared with placebo, had 0.2% significantly lower median HbA1c at 3 years (P < 0.001). In patients remaining on their allocated therapy, the HbA1c difference at 3 years (309 acarbose, 470 placebo) was 0.5% lower median HbA1c (8.1 vs. 8.6%, P < 0.0001). Acarbose appeared to be equally efficacious when given in addition to diet alone; in addition to monotherapy with a sulfonylurea, metformin, or insulin; or in combination with more complex treatment regimens. No significant differences were seen in FPG, body weight, incidence of hypoglycemia, or frequency of major clinical events. CONCLUSIONS: Acarbose significantly improved glycemic control over 3 years in patients with established type 2 diabetes, irrespective of concomitant therapy for diabetes. Careful titration of acarbose is needed in view of the increased noncompliance rate seen secondary to the known side effects.  (+info)

(6/145) Changes of fermentation pathways of fecal microbial communities associated with a drug treatment that increases dietary starch in the human colon.

Acarbose inhibits starch digestion in the human small intestine. This increases the amount of starch available for microbial fermentation to acetate, propionate, and butyrate in the colon. Relatively large amounts of butyrate are produced from starch by colonic microbes. Colonic epithelial cells use butyrate as an energy source, and butyrate causes the differentiation of colon cancer cells. In this study we investigated whether colonic fermentation pathways changed during treatment with acarbose. We examined fermentations by fecal suspensions obtained from subjects who participated in an acarbose-placebo crossover trial. After incubation with [1-13C]glucose and 12CO2 or with unlabeled glucose and 13CO2, the distribution of 13C in product C atoms was determined by nuclear magnetic resonance spectrometry and gas chromatography-mass spectrometry. Regardless of the treatment, acetate, propionate, and butyrate were produced from pyruvate formed by the Embden-Meyerhof-Parnas pathway. Considerable amounts of acetate were also formed by the reduction of CO2. Butyrate formation from glucose increased and propionate formation decreased with acarbose treatment. Concomitantly, the amounts of CO2 reduced to acetate were 30% of the total acetate in untreated subjects and 17% of the total acetate in the treated subjects. The acetate, propionate, and butyrate concentrations were 57, 20, and 23% of the total final concentrations, respectively, for the untreated subjects and 57, 13, and 30% of the total final concentrations, respectively, for the treated subjects.  (+info)

(7/145) Structure-function relationships in glucoamylases encoded by variant Saccharomycopsis fibuligera genes.

The mutation Gly467-->Ser in Glu glucoamylase was designed to investigate differences between two highly homologous wild-type Saccharomycopsis fibuligera Gla and Glu glucoamylases. Gly467, localized in the conserved active site region, S5, is replaced by Ser in the Gla glucoamylase. These amino acid residues are the only two known to occupy this position in the elucidated glucoamylase sequences. The data from the kinetic analysis revealed that replacement of Gly467 with Ser in Glu glucoamylase decreased the kcat towards all substrates tested to values comparable with those of the Gla enzyme. Moreover, the mutant glucoamylase appeared to be less stable compared to the wild-type Glu glucoamylase with respect to thermal unfolding. Microcalorimetric titration studies of the interaction with the inhibitor acarbose indicated differences in the binding between Gla and Glu enzymes. The Gla glucoamylase, although less active, binds acarbose stronger (Ka congruent with 10(13).M(-1)) than the Glu enzyme (Ka congruent with 10(12).M(-1)). In all enzymes studied, the binding of acarbose was clearly driven by enthalpy, with a slightly favorable entropic contribution. The binding of another glucoamylase inhibitor, 1-deoxynojirimycin, was about 8-9 orders of magnitude weaker (Ka congruent with 10(4).M(-1)) than that of acarbose. From comparison of kinetic parameters for the nonglycosylated and glycosylated enzymes it can be deduced that the glycosylation does not play a critical role in enzymatic activity. However, results from differential scanning calorimetry demonstrate an important role of the carbohydrate moiety in the thermal stability of glucoamylase.  (+info)

(8/145) Mechanism of porcine pancreatic alpha-amylase inhibition of amylose and maltopentaose hydrolysis by kidney bean (Phaseolus vulgaris) inhibitor and comparison with that by acarbose.

The effects of Phaseolus vulgaris inhibitor (alpha-AI) on the amylose and maltopentaose hydrolysis catalysed by porcine pancreatic alpha-amylase (PPA) were investigated. Based on a statistical analysis of the kinetic data and using the general velocity equation, which is valid at equilibrium for all types of inhibition in a single-substrate reaction, it was concluded that the inhibitory mode is of the mixed noncompetitive type involving two molecules of inhibitor. In line with this conclusion, the Lineweaver-Burk primary plots intersect in the second quadrant and the secondary plots of the slopes and the intercepts versus the inhibitor concentrations are parabolic curves, whether the substrate used was amylose or maltopentaose. A specific inhibition model of the mixed noncompetitive type applies here. This model differs from those previously proposed for acarbose [Al Kazaz, M., Desseaux, V., Marchis-Mouren, G., Payan, F., Forest, E. & Santimone, M. (1996) Eur. J. Biochem. 241, 787-796 and Al Kazaz, M., Desseaux, V., Marchis-Mouren, G., Prodanov, E. & Santimone, M. (1998) Eur. J. Biochem. 252, 100-107]. In particular, with alpha-AI, the inhibition takes place only when PPA and alpha-AI are preincubated together before the substrate is added. This shows that the inhibitory PPA-alphaAI complex is formed during the preincubation period. Secondly, other inhibitory complexes are formed, in which two molecules of inhibitor are bound to either the free enzyme or the enzyme-substrate complex. The catalytic efficiency was determined both with and without inhibitor. Using the same molar concentration of inhibitor, alpha-AI was found to be a much stronger inhibitor than acarbose. However, when the inhibitor amount is expressed on a weight basis (mg x L-1), the opposite conclusion is drawn. In addition, limited proteolysis was performed on PPA alone and on the alpha-AI-PPA complex. The results show that, in the complex, PPA is more sensitive to subtilisin attack, and shorter fragments are obtained. These data reflect the conformational changes undergone by PPA as the result of the protein inhibitor binding, which differ from those previously observed with acarbose.  (+info)

*  Alpha-glucosidase
Acarbose may have the capability to stop developing diabetic symptoms. Hence, alpha-glucosidase inhibitors (like acarbose) are ... Diabetes: Acarbose, an alpha-glucosidase inhibitor, competitively and reversibly inhibits alpha-glucosidase in the intestines. ...
*  Glucosidases
They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2. DNA ...
*  Acarbose
... (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a ... Since acarbose prevents the digestion of complex carbohydrates, the drug should be taken at the start of main meals (taken with ... Because acarbose blocks the breakdown of table sugar and other complex sugars, fruit juice or starchy foods will not ... Adults may take doses of 25 mg 3 times daily, increasing to 100 mg 3 times a day.[citation needed] Since acarbose prevents the ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: A: Acarbose
Consumer information regarding drug use, side effects, interactions and pill identification. ...
*  List of drugs: Prb-Prn
Precef preclamol (INN) Precose (Bayer AG). Redirects to acarbose. Pred-G Pred Predair Predamide prednazate (INN) prednazoline ( ...
*  List of drugs: G
Redirects to acarbose. Glucohexal (Hexal Australia) [Au]. Redirects to metformin. Glucophage (Sanofi) glucosamine (INN) ...
*  Anti-obesity medication
"acarbose - oral, Precose". MedicineNet. MedicineNet. Retrieved 2014-01-27. "Peptimmune homepage". peptimmune.com. McBride, Ryan ... A similar medication designed for patients with Type 2 diabetes is Acarbose; which partially blocks absorption of carbohydrates ...
*  Alpha-glucosidase inhibitor
Miglitol is fairly well absorbed by the body, as opposed to acarbose. Moreover, acarbose inhibits pancreatic alpha-amylase in ... there are subtle differences between acarbose and miglitol. Acarbose is an oligosaccharide, whereas miglitol resembles a ... Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha- ... Examples of alpha-glucosidase inhibitors include: Acarbose- Precose Miglitol - Glyset Voglibose Even though the drugs have a ...
*  Valienamine
June 2002). "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the ... Valienamine is a C-7 aminocyclitol found as a substructure of pseudooligosaccharides such as the antidiabetic drug acarbose and ... Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes Treatment". Clinical Drug Investigation. 22 ...
*  Glycomimetic
Acarbose is an enzyme inhibitor that is used as a drug against type 2 diabetes. Miglustat is an iminosugar in which the ring ... Tamiflu is an enzyme inhibitor that blocks the action of influenza virus neuraminidases (sialidases). Acarbose is a ...
*  Actinoplanes
Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes Treatment". Clinical Drug Investigation. 22 ... a precursor to the antidiabetic drug acarbose and the antibiotic validamycin), teicoplanin, and ramoplanin. Euzéby, J. P. " ...
*  Beano (dietary supplement)
Another study indicates it may interfere with the diabetic medication acarbose. Besides the ingredient α-GAL, Beano tablets ... Lettieri JT, Dain B (1998). "Effects of beano on the tolerability and pharmacodynamics of acarbose". Clin Ther. 20 (3): 497-504 ...
*  Miglitol
In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not ...
*  Acarviosin
... is part of the potent α-amylase inhibitor acarbose and its derivatives. The nitrogen atom binds to α-amylase more ...
*  Glycoside hydrolase family 15
The 3D structure of the pseudo-tetrasaccharide acarbose complexed with glucoamylase II(471) from Aspergillus awamori var. X100 ... Aleshin AE, Firsov LM, Honzatko RB (1994). "Refined structure for the complex of acarbose with glucoamylase from Aspergillus ...
*  Sucrase-isomaltase
Within the -1 subsite, isomaltose's non-reducing glucose ring was aligned to that of acarbose. Not only has the structure of ...
*  Prediabetes
Metformin and acarbose help prevent the development of frank diabetes, and also have a good safety profile. Evidence also ...
*  Hypoglycemia
One situation where starch may be less effective than glucose or sucrose is when a person is taking acarbose. Since acarbose ... Starch is quickly digested to glucose (unless the person is taking acarbose), but adding fat or protein retards digestion. ...
*  Voglibose
There are three drugs which belong to this class, acarbose, miglitol and voglibose, of which voglibose is the newest. https:// ...
*  Maltase-glucoamylase
2008). "Clinical, endocrine, and metabolic effects of acarbose, an alpha-glucosidase inhibitor, in overweight and nonoverweight ...
*  Macrophyte
... prepared from the leaf of Ludwigia adscendens exhibits alpha-glucosidase inhibitory activity more potent than that of acarbose ...
*  Glycoside hydrolase
Inhibitors that are in clinical use include the anti-diabetic drugs acarbose and miglitol, and the antiviral drugs oseltamivir ...
*  Anti-diabetic medication
Typical reductions in glycated hemoglobin (A1C) values are 0.5-1.0%. miglitol acarbose voglibose These medications are rarely ... Acarbose Meglitinides - nateglinide Combination of sulfonylureas plus metformin - known by generic names of the two drugs No ...
*  Actinoplanes utahensis
... is a bacteria and is a source of the drug acarbose (an alpha-glucosidase inhibtor) used in the treatment ...
*  Dorzolamide/timolol
The FDA upheld their previous exclusivity decisions on acarbose and granisetron, allowing both Hi-Tech and Apotex to make a ...
Certified Online Pharmacy Canada - Acarbose Metformin Combination  Certified Online Pharmacy Canada - Acarbose Metformin Combination
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Acarbose | Define Acarbose at Dictionary.com  Acarbose | Define Acarbose at Dictionary.com
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acarbose  acarbose
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Acarbose Dosage Guide with Precautions - Drugs.com  Acarbose Dosage Guide with Precautions - Drugs.com
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Precose (Acarbose): Side Effects, Interactions, Warning, Dosage & Uses  Precose (Acarbose): Side Effects, Interactions, Warning, Dosage & Uses
Acarbose) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... The fraction of acarbose that is absorbed as intact drug is almost completely excreted by the kidneys. When acarbose was given ... acarbose) Tablets. DESCRIPTION. PRECOSE® (acarbose tablets) is an oral alpha-glucosidase inhibitor for use in the management of ... Acarbose is soluble in water and has a pKa of 5.1. Its empirical formula is C25H43NO18 and its chemical structure is as follows ...
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Acarbose (Oral Route) Description and Brand Names - Mayo Clinic  Acarbose (Oral Route) Description and Brand Names - Mayo Clinic
Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. It may be used alone or in combination with ... Acarbose is used to treat type 2 diabetes. Normally, your pancreas releases insulin into the blood stream after you eat. ...
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Untersuchungen zum Acarbose-Metabolismus von Actinoplanes sp.  Untersuchungen zum Acarbose-Metabolismus von Actinoplanes sp.
Acarbose hat als Inhibitor von Hydrolasen alpha-1,4-glykosidischer Bindungen medizinische Bedeutung. Das Acarbose-Biosynthese- ... Prompted by the structural similarity between acarbose and maltotetraose, the effects of acarbose on the metabolism of maltose ... Acarbose acts as an inhibitor of alpha-glucosidases and is therefore clinically used. The biosynthesis gene cluster (acb) was ... The proposed model describes a pathway in which acarbose might function as a carbophor. The molecule is secreted into the ...
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Acarbose and Older Adults With Postprandial Hypotension - Full Text View - ClinicalTrials.gov  Acarbose and Older Adults With Postprandial Hypotension - Full Text View - ClinicalTrials.gov
Drug: Acarbose Acarbose 50 mg given during Meal Test and Acarbose 25 mg taken with first bite of the next 3 meals. ... During the second Meal Test subject will receive Acarbose 50mg and will take Acarbose 25mg with first bite of each of the next ... Acarbose and Older Adults With Postprandial Hypotension (PPH). The safety and scientific validity of this study is the ... Starting the day following each meal test, each subject with PPH will take either acarbose 25 mg po tid (prior to each meal) or ...
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Acarbose Medication - Uses, Side Effects and Precautions of Acarbose  Acarbose Medication - Uses, Side Effects and Precautions of Acarbose
What is Acarbose? *Acarbose is an oral medication used to treat type 2 (noninsulin-dependent) diabetes. It is used when high ... How to take Acarbose?. *There is no fixed dosage regimen for the management of diabetes mellitus with Acarbose or any other ... In general, though, Acarbose should be taken three times daily at the start (with the first bite) of each main meal. Acarbose ... Continue to take Acarbose even if you feel well. Do not stop taking Acarbose without talking to your doctor. ...
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Global Acarbose Market Research Report 2017 : ReportsnReports  Global Acarbose Market Research Report 2017 : ReportsnReports
In this report, the global Acarbose market is valued at... ... 112 Pages Report] Check for Discount on Global Acarbose Market ... Global Acarbose Market Research Report 2017 Table of Contents. Global Acarbose Market Research Report 2017. 1 Acarbose Market ... 5.3 Global Acarbose Price by Type (2012-2017). 5.4 Global Acarbose Production Growth by Type (2012-2017). 6 Global Acarbose ... 2.5 Acarbose Market Competitive Situation and Trends. 2.5.1 Acarbose Market Concentration Rate. 2.5.2 Acarbose Market Share of ...
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Acarbose - Wikipedia  Acarbose - Wikipedia
Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a ... Since acarbose prevents the digestion of complex carbohydrates, the drug should be taken at the start of main meals (taken with ... Because acarbose blocks the breakdown of table sugar and other complex sugars, fruit juice or starchy foods will not ... Adults may take doses of 25 mg 3 times daily, increasing to 100 mg 3 times a day.[citation needed] Since acarbose prevents the ...
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Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS)  Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS)
Acarbose group will be treated by acarbose (its dose will be 100 mg/day in the first week,. 200 mg/ day in the second week and ... compare the effect of Metformin and Acarbose to weight reduction. Outcome Time Frame:. After 3 months of Metformin or Acarbose ... Acarbose Treatment in Infertile Overweight Women With PCOS: A Prospective Randomized Clinical Trial. Trial Phase:. Phase 4. ... acarbose). in infertile overweight women with PCOS.. The study population comprises all infertile patients with diagnosis of ...
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Cost-effectiveness of acarbose for the management of impaired glucose tolerance in Sweden.  Cost-effectiveness of acarbose for the management of impaired glucose tolerance in Sweden.
For the high CV risk subgroups, acarbose treatment dominated placebo (i.e. acarbose was more effective, less costly). ... fully offset the cost of acarbose. We conclude that acarbose is likely to be cost-effective in the management of impaired ... Cost-effectiveness of acarbose for the management of impaired glucose tolerance in Sweden.. Quilici, S ... Acarbose significantly reduces the incidence of diabetes and CV events in IGT patients. We predict this may translate into ...
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Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.gov  Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.gov
Active Comparator: Bayer Acarbose Drug: Bayer Acarbose Bayer Acarbose 50 mg 3 times a day ... Experimental: EMS Acarbose Drug: EMS Acarbose EMS Acarbose 50 mg 3 times a day ... Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus. The safety and scientific validity of ... The Purpose of This Study is to Evaluate the Efficacy and Safety of Acarbose in Type 2 Diabetic Patients Using Two Different ...
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1999 - Acarbose was effective in maintaining glycemic control in type 2 diabetes mellitus
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... acarbose should predominantly affect postprandial hyperglycemia. This is supported by the current data showing that acarbose ... Acarbose was effective in maintaining glycemic control in type 2 diabetes mellitus but was associated with adverse effects ACP ... At 3 years, patients in the acarbose group had a lower median HbA1c level {8.3% vs 8.6%, P = 0.003}*, a lower rate of ... Patients were allocated to acarbose (n = 973), titrated to a maximum dose of 100 mg 3 times/d, or placebo (n = 973). Patients ...
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A COMPARATIVE STUDY OF MIGLITOL AND ACARBOSE ADD ON THERAPY INTENDED FOR BETTER GLYCAEMIC CONTROL IN TYPE 2 DIABETES MELLITUS -...  A COMPARATIVE STUDY OF MIGLITOL AND ACARBOSE ADD ON THERAPY INTENDED FOR BETTER GLYCAEMIC CONTROL IN TYPE 2 DIABETES MELLITUS -...
Objectives: This study was done to find out the comparative efficacy of Miglitol and Acarbose as add on therapy in patients of ... Thus α glucosidase inhibitors like Miglitol and acarbose are sure to play an important role as an add on therapy when first ... A COMPARATIVE STUDY OF MIGLITOL AND ACARBOSE ADD ON THERAPY INTENDED FOR BETTER GLYCAEMIC CONTROL IN TYPE 2 DIABETES MELLITUS ... FBS 0.05 signifying Miglitol to be better than Acarbose in terms of glycaemic controlin type 2 D.M.. Conclusions: Type 2 ...
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Acarbose or (Precose in US, Glucobay in Europe, Prandase in Canada) is prescribed for treating Type 2 diabetes. It can be ... it described that acarbose works by competiting against carbohydrates found in food supposedly binding to enzyme in order to be ... digested, but now the place of binding is blocked by acarbose. As a result, less carbohydrate will be broken down into glucose ...
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  • Blocking the absorption of carbohydrates at the brush border of the small intestine with acarbose (an alpha-glucosidase inhibitor) seems a promising possibility as a potential therapeutic agent. (clinicaltrials.gov)
  • Acarbose tablets are available as 100 mg tablets for oral use. (nih.gov)
  • If a patient using acarbose suffers from a bout of hypoglycemia, the patient must eat something containing monosaccharides, such as glucose tablets or gel (GlucoBurst, Insta-Glucose, Glutose, Level One) and a doctor should be called. (wikipedia.org)
  • citation needed] Since acarbose prevents the degradation of complex carbohydrates into glucose, some carbohydrate will remain in the intestine and be delivered to the colon. (wikipedia.org)
  • Before taking acarbose, tell your doctor if you have liver disease, or any type of stomach or intestinal disorder. (cardiosmart.org)
  • However, a recent large study concludes "acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes. (wikipedia.org)
  • Acarbose is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. (cardiosmart.org)
  • Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. (mayoclinic.org)
  • A possible explanation for the differing opinions is an observation that acarbose is significantly more effective in patients eating a relatively high carbohydrate Eastern diet. (wikipedia.org)
  • The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of blood pressure after eating), which can result in falls. (clinicaltrials.gov)
  • You also should not use acarbose if you have inflammatory bowel disease, an ulcer or blockage in your intestines, or cirrhosis of the liver. (cardiosmart.org)
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