OrganismsDiseasesChemicals and Drugs
AcarboseTrisaccharidesalpha-GlucosidasesImino PyranosesHypoglycemic AgentsGlycogen Debranching Enzyme Systemalpha-AmylasesPostgastrectomy SyndromesGlucosidasesGlucan 1,4-alpha-GlucosidaseMicromonosporaceaeMaltose
Acarbose
An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.
Trisaccharides
Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.
alpha-Glucosidases
Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.
Imino Pyranoses
Six-carbon pyranose sugars in which the OXYGEN is replaced by a NITROGEN atom.
Hypoglycemic Agents
Substances which lower blood glucose levels.
Glycogen Debranching Enzyme System
1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrolase. An enzyme system having both 4-alpha-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33) activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or another 1,4-alpha-D-glucan. As a glucosidase it catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-1,6-glucosidase activity is deficient in glycogen storage disease type III.
alpha-Amylases
Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.
Postgastrectomy Syndromes
Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.
Glucosidases
Enzymes that hydrolyze O-glucosyl-compounds. (Enzyme Nomenclature, 1992) EC 3.2.1.-.
Glucan 1,4-alpha-Glucosidase
An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.
Micromonosporaceae
A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.
Maltose
A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)

Manganese sulfate-dependent glycosylation of endogenous glycoproteins in human skeletal muscle is catalyzed by a nonglucose 6-P-dependent glycogen synthase and not glycogenin. (1/145)

Glycogenin, a Mn2+-dependent, self-glucosylating protein, is considered to catalyze the initial glucosyl transfer steps in glycogen biogenesis. To study the physiologic significance of this enzyme, measurements of glycogenin mediated glucose transfer to endogenous trichloroacetic acid precipitable material (protein-bound glycogen, i.e., glycoproteins) in human skeletal muscle were attempted. Although glycogenin protein was detected in muscle extracts, activity was not, even after exercise that resulted in marked glycogen depletion. Instead, a MnSO4-dependent glucose transfer to glycoproteins, inhibited by glycogen and UDP-pyridoxal (which do not affect glycogenin), and unaffected by CDP (a potent inhibitor of glycogenin), was consistently detected. MnSO4-dependent activity increased in concert with glycogen synthase fractional activity after prolonged exercise, and the MnSO4-dependent enzyme stimulated glucosylation of glycoproteins with molecular masses lower than those glucosylated by glucose 6-P-dependent glycogen synthase. Addition of purified glucose 6-P-dependent glycogen synthase to the muscle extract did not affect MnSO4-dependent glucose transfer, whereas glycogen synthase antibody completely abolished MnSO4-dependent activity. It is concluded that: (1) MnSO4-dependent glucose transfer to glycoproteins is catalyzed by a nonglucose 6-P-dependent form of glycogen synthase; (2) MnSO4-dependent glycogen synthase has a greater affinity for low molecular mass glycoproteins and may thus play a more important role than glucose 6-P-dependent glycogen synthase in the initial stages of glycogen biogenesis; and (3) glycogenin is generally inactive in human muscle in vivo.  (+info)

Modes of action of acarbose hydrolysis and transglycosylation catalyzed by a thermostable maltogenic amylase, the gene for which was cloned from a Thermus strain. (2/145)

A maltogenic amylase gene was cloned in Escherichia coli from a gram-negative thermophilic bacterium, Thermus strain IM6501. The gene encoded an enzyme (ThMA) with a molecular mass of 68 kDa which was expressed by the expression vector p6xHis119. The optimal temperature of ThMA was 60 degrees C, which was higher than those of other maltogenic amylases reported so far. Thermal inactivation kinetic analysis of ThMA indicated that it was stabilized in the presence of 10 mM EDTA. ThMA harbored both hydrolysis and transglycosylation activities. It hydrolyzed beta-cyclodextrin and starch mainly to maltose and pullulan to panose. ThMA not only hydrolyzed acarbose, an amylase inhibitor, to glucose and pseudotrisaccharide (PTS) but also transferred PTS to 17 sugar acceptors, including glucose, fructose, maltose, cellobiose, etc. Structural analysis of acarbose transfer products by using methylation, thin-layer chromatography, high-performance ion chromatography, and nuclear magnetic resonance indicated that PTS was transferred primarily to the C-6 of the acceptors and at lower degrees to the C-3 and/or C-4. The transglycosylation of sugar to methyl-alpha-D-glucopyranoside by forming an alpha-(1,3)-glycosidic linkage was demonstrated for the first time by using acarbose and ThMA. Kinetic analysis of the acarbose transfer products showed that the C-4 transfer product formed most rapidly but readily hydrolyzed, while the C-6 transfer product was stable and accumulated in the reaction mixture as the main product.  (+info)

The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. (3/145)

The putative biosynthetic gene cluster for the alpha-glucosidase inhibitor acarbose was identified in the producer Actinoplanes sp. 50/110 by cloning a DNA segment containing the conserved gene for dTDP-D-glucose 4,6-dehydratase, acbB. The two flanking genes were acbA (dTDP-D-glucose synthase) and acbC, encoding a protein with significant similarity to 3-dehydroquinate synthases (AroB proteins). The acbC gene was overexpressed heterologously in Streptomyces lividans 66, and the product was shown to be a C7-cyclitol synthase using sedo-heptulose 7-phosphate, but not ido-heptulose 7-phosphate, as its substrate. The cyclization product, 2-epi-5-epi-valiolone ((2S,3S,4S,5R)-5-(hydroxymethyl)cyclohexanon-2,3,4,5-tetrol), is a precursor of the valienamine moiety of acarbose. A possible five-step reaction mechanism is proposed for the cyclization reaction catalyzed by AcbC based on the recent analysis of the three-dimensional structure of a eukaryotic 3-dehydroquinate synthase domain (Carpenter, E. P., Hawkins, A. R., Frost, J. W., and Brown, K. A. (1998) Nature 394, 299-302).  (+info)

Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli. (4/145)

The pseudooligosaccharide acarbose is a potent inhibitor of amylases, glucosidases, and cyclodextrin glycosyltransferase and is clinically used for the treatment of so-called type II or insulin-independent diabetes. The compound consists of an unsaturated aminocyclitol, a deoxyhexose, and a maltose. The unsaturated aminocyclitol moiety (also called valienamine) is primarily responsible for the inhibition of glucosidases. Due to its structural similarity to maltotetraose, we have investigated whether acarbose is recognized as a substrate by the maltose/maltodextrin system of Escherichia coli. Acarbose at millimolar concentrations specifically affected the growth of E. coli K-12 on maltose as the sole source of carbon and energy. Uptake of radiolabeled maltose was competitively inhibited by acarbose, with a Ki of 1.1 microM. Maltose-grown cells transported radiolabeled acarbose, indicating that the compound is recognized as a substrate. Studying the interaction of acarbose with purified maltoporin in black lipid membranes revealed that the kinetics of acarbose binding to LamB is asymmetric. The on-rate of acarbose is approximately 30 times lower when the molecule enters the pore from the extracellular side than when it enters from the periplasmic side. Acarbose could not be utilized as a carbon source since the compound alone was not a substrate of amylomaltase (MalQ) and was only poorly attacked by maltodextrin glucosidase (MalZ).  (+info)

A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44) (5/145)

OBJECTIVE: To determine the degree to which alpha-glucosidase inhibitors, with their unique mode of action primarily reducing postprandial hyperglycemia, offer an additional therapeutic approach in the long-term treatment of type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied 1,946 patients (63% men) who were previously enrolled in the U.K. Prospective Diabetes Study (UKPDS). The patients were randomized to acarbose (n = 973), titrating to a maximum dose of 100 mg three times per day, or to matching placebo (n = 973). Mean +/- SD age was 59 +/- 9 years, body weight 84 +/- 17 kg, diabetes duration 7.6 +/- 2.9 years, median (interquartile range) HbA1c 7.9% (6.7-9.5), and fasting plasma glucose (FPG) 8.7 mmol/l (6.8-11.1). Fourteen percent of patients were treated with diet alone, 52% with monotherapy, and 34% with combined therapy. Patients were monitored in UKPDS clinics every 4 months for 3 years. The main outcome measures were HbA1c, FPG, body weight, compliance with study medication, incidence of side effects, and frequency of major clinical events. RESULTS: At 3 years, a lower proportion of patients were taking acarbose compared with placebo (39 vs. 58%, P < 0.0001), the main reasons for noncompliance being flatulence (30 vs. 12%, P < 0.0001) and diarrhea (16 vs. 8%, P < 0.05). Analysis by intention to treat showed that patients allocated to acarbose, compared with placebo, had 0.2% significantly lower median HbA1c at 3 years (P < 0.001). In patients remaining on their allocated therapy, the HbA1c difference at 3 years (309 acarbose, 470 placebo) was 0.5% lower median HbA1c (8.1 vs. 8.6%, P < 0.0001). Acarbose appeared to be equally efficacious when given in addition to diet alone; in addition to monotherapy with a sulfonylurea, metformin, or insulin; or in combination with more complex treatment regimens. No significant differences were seen in FPG, body weight, incidence of hypoglycemia, or frequency of major clinical events. CONCLUSIONS: Acarbose significantly improved glycemic control over 3 years in patients with established type 2 diabetes, irrespective of concomitant therapy for diabetes. Careful titration of acarbose is needed in view of the increased noncompliance rate seen secondary to the known side effects.  (+info)

Changes of fermentation pathways of fecal microbial communities associated with a drug treatment that increases dietary starch in the human colon. (6/145)

Acarbose inhibits starch digestion in the human small intestine. This increases the amount of starch available for microbial fermentation to acetate, propionate, and butyrate in the colon. Relatively large amounts of butyrate are produced from starch by colonic microbes. Colonic epithelial cells use butyrate as an energy source, and butyrate causes the differentiation of colon cancer cells. In this study we investigated whether colonic fermentation pathways changed during treatment with acarbose. We examined fermentations by fecal suspensions obtained from subjects who participated in an acarbose-placebo crossover trial. After incubation with [1-13C]glucose and 12CO2 or with unlabeled glucose and 13CO2, the distribution of 13C in product C atoms was determined by nuclear magnetic resonance spectrometry and gas chromatography-mass spectrometry. Regardless of the treatment, acetate, propionate, and butyrate were produced from pyruvate formed by the Embden-Meyerhof-Parnas pathway. Considerable amounts of acetate were also formed by the reduction of CO2. Butyrate formation from glucose increased and propionate formation decreased with acarbose treatment. Concomitantly, the amounts of CO2 reduced to acetate were 30% of the total acetate in untreated subjects and 17% of the total acetate in the treated subjects. The acetate, propionate, and butyrate concentrations were 57, 20, and 23% of the total final concentrations, respectively, for the untreated subjects and 57, 13, and 30% of the total final concentrations, respectively, for the treated subjects.  (+info)

Structure-function relationships in glucoamylases encoded by variant Saccharomycopsis fibuligera genes. (7/145)

The mutation Gly467-->Ser in Glu glucoamylase was designed to investigate differences between two highly homologous wild-type Saccharomycopsis fibuligera Gla and Glu glucoamylases. Gly467, localized in the conserved active site region, S5, is replaced by Ser in the Gla glucoamylase. These amino acid residues are the only two known to occupy this position in the elucidated glucoamylase sequences. The data from the kinetic analysis revealed that replacement of Gly467 with Ser in Glu glucoamylase decreased the kcat towards all substrates tested to values comparable with those of the Gla enzyme. Moreover, the mutant glucoamylase appeared to be less stable compared to the wild-type Glu glucoamylase with respect to thermal unfolding. Microcalorimetric titration studies of the interaction with the inhibitor acarbose indicated differences in the binding between Gla and Glu enzymes. The Gla glucoamylase, although less active, binds acarbose stronger (Ka congruent with 10(13).M(-1)) than the Glu enzyme (Ka congruent with 10(12).M(-1)). In all enzymes studied, the binding of acarbose was clearly driven by enthalpy, with a slightly favorable entropic contribution. The binding of another glucoamylase inhibitor, 1-deoxynojirimycin, was about 8-9 orders of magnitude weaker (Ka congruent with 10(4).M(-1)) than that of acarbose. From comparison of kinetic parameters for the nonglycosylated and glycosylated enzymes it can be deduced that the glycosylation does not play a critical role in enzymatic activity. However, results from differential scanning calorimetry demonstrate an important role of the carbohydrate moiety in the thermal stability of glucoamylase.  (+info)

Mechanism of porcine pancreatic alpha-amylase inhibition of amylose and maltopentaose hydrolysis by kidney bean (Phaseolus vulgaris) inhibitor and comparison with that by acarbose. (8/145)

The effects of Phaseolus vulgaris inhibitor (alpha-AI) on the amylose and maltopentaose hydrolysis catalysed by porcine pancreatic alpha-amylase (PPA) were investigated. Based on a statistical analysis of the kinetic data and using the general velocity equation, which is valid at equilibrium for all types of inhibition in a single-substrate reaction, it was concluded that the inhibitory mode is of the mixed noncompetitive type involving two molecules of inhibitor. In line with this conclusion, the Lineweaver-Burk primary plots intersect in the second quadrant and the secondary plots of the slopes and the intercepts versus the inhibitor concentrations are parabolic curves, whether the substrate used was amylose or maltopentaose. A specific inhibition model of the mixed noncompetitive type applies here. This model differs from those previously proposed for acarbose [Al Kazaz, M., Desseaux, V., Marchis-Mouren, G., Payan, F., Forest, E. & Santimone, M. (1996) Eur. J. Biochem. 241, 787-796 and Al Kazaz, M., Desseaux, V., Marchis-Mouren, G., Prodanov, E. & Santimone, M. (1998) Eur. J. Biochem. 252, 100-107]. In particular, with alpha-AI, the inhibition takes place only when PPA and alpha-AI are preincubated together before the substrate is added. This shows that the inhibitory PPA-alphaAI complex is formed during the preincubation period. Secondly, other inhibitory complexes are formed, in which two molecules of inhibitor are bound to either the free enzyme or the enzyme-substrate complex. The catalytic efficiency was determined both with and without inhibitor. Using the same molar concentration of inhibitor, alpha-AI was found to be a much stronger inhibitor than acarbose. However, when the inhibitor amount is expressed on a weight basis (mg x L-1), the opposite conclusion is drawn. In addition, limited proteolysis was performed on PPA alone and on the alpha-AI-PPA complex. The results show that, in the complex, PPA is more sensitive to subtilisin attack, and shorter fragments are obtained. These data reflect the conformational changes undergone by PPA as the result of the protein inhibitor binding, which differ from those previously observed with acarbose.  (+info)

Effects of the α-glucosidase inhibitor acarbose on postprandial serum glucose and insulin concentrations in healthy dogs -...
TY - JOUR. T1 - Effects of the α-glucosidase inhibitor acarbose on postprandial serum glucose and insulin concentrations in healthy dogs. AU - Robertson, Jane. AU - Nelson, Richard W. AU - Kass, Philip H. AU - Neal, Larry. PY - 1999/5. Y1 - 1999/5. N2 - Objective - To determine effects of acarbose on baseline and postprandial serum glucose and insulin concentrations in healthy dogs, if effects of acarbose were dosage related, and if acarbose caused any short- term adverse effects. Animals - 5 healthy dogs fed a high-fiber diet. Procedure - A Latin-square design was used. During each 1-week treatment period, dogs were given a placebo or 25, 50, 100, or 200 mg of acarbose, PO, twice daily immediately prior to feeding. There was a 1-week interval between periods. At the end of each treatment period, serum glucose and insulin concentrations were measured prior to feeding and at 30- to 60-minute intervals for 6 hours after feeding. Results - Baseline serum glucose and insulin concentrations, insulin ...
https://ucdavis.pure.elsevier.com/en/publications/effects-of-the-%CE%B1-glucosidase-inhibitor-acarbose-on-postprandial-s/
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Cost-effectiveness of acarbose for the management of impaired glucose tolerance in Sweden.Cost-effectiveness of acarbose for the management of impaired glucose tolerance in Sweden.
We assessed the cost-effectiveness of acarbose in the management of patients with impaired glucose tolerance (IGT) in Sweden, based on progression to type 2 diabetes (T2D) and cardiovascular (CV) events reported in the STOP-NIDDM trial population, including high-risk subgroups. The cost per patient free from T2D was SEK28 000 or SEK1260 per diabetes free month prior to progression to T2D. The cost per patient free from CV events was SEK101 000 or SEK5000 per CV event free month. For the high CV risk subgroups, acarbose treatment dominated placebo (i.e. acarbose was more effective, less costly).. Acarbose significantly reduces the incidence of diabetes and CV events in IGT patients. We predict this may translate into healthcare cost savings that partially or, in patients at high CV risk, fully offset the cost of acarbose. We conclude that acarbose is likely to be cost-effective in the management of impaired glucose tolerance.. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:38159
Effect of the disaccharidase inhibitor acarbose on meal glucose tolerance and timing of insulin administration in insulin...
TY - JOUR. T1 - Effect of the disaccharidase inhibitor acarbose on meal glucose tolerance and timing of insulin administration in insulin-dependent diabetes. AU - Dimitriadis, G.. AU - Tessari, P.. AU - Rizza, R.. PY - 1982/1/1. Y1 - 1982/1/1. UR - http://www.scopus.com/inward/record.url?scp=0020416793&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0020416793&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0020416793. VL - 30. SP - 741A. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 4. ER - ...
https://mayoclinic.pure.elsevier.com/en/publications/effect-of-the-disaccharidase-inhibitor-acarbose-on-meal-glucose-t
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1999 - Acarbose was effective in maintaining glycemic control in type 2 diabetes mellitus but was associated with...1999 - Acarbose was effective in maintaining glycemic control in type 2 diabetes mellitus but was associated with...
Optimal glycemic control in type 2 diabetes may require multiple forms of therapy, and an increasing number of hypoglycemic agents are now available. The study by Holman and colleagues describes the glucose-lowering properties of acarbose, an α-glucosidase inhibitor that is used as an adjunct to preexisting therapy. This study confirms earlier reports of the efficacy of acarbose (1). Based on its mechanism of action, which is the delay of carbohydrate absorption, acarbose should predominantly affect postprandial hyperglycemia. This is supported by the current data showing that acarbose had no effect on FPG level but was associated with lowered HbA1c levels at 3 years. Although increased gut carbohydrate absorption has not traditionally been seen as a contributor to postprandial hyperglycemia, recent data suggest that splanchnic glucose uptake may be altered (2). Delayed entry of glucose from the gut by α-glucosidase inhibition may alleviate these altered splanchnic responses. The major problem ...
http://www.acpjc.org/Content/131/3/issue/ACPJC-1999-131-3-074.htm
AcarboseAcarbose
Acarbose is pseudo-oligosaccharide with a terminal C7-cyclitol patented in 1975 by Bayer. Acarbose is a component of the amylostatin complex produced by species of Actinoplanes and Streptomyces. Acarbose acts as a potent inhibitor of α-glucosidases and saccharases. Since 1990, acarbose has been used therapeutically for the treatment of type 2 diabetes ...
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Untersuchungen zum Acarbose-Metabolismus von Actinoplanes sp.Untersuchungen zum Acarbose-Metabolismus von Actinoplanes sp.
Acarbose acts as an inhibitor of alpha-glucosidases and is therefore clinically used. The biosynthesis gene cluster (acb) was identified and partly characterized. The proposed model describes a pathway in which acarbose might function as a carbophor. The molecule is secreted into the medium where, after hydrolysis of starch, it is charged with additional glucose moieties. Re-uptake by a binding-protein dependent ABC importer AcbHFG would then result in a net gain of carbon and energy. Besides extracting glucose from the extracellular pool acarbose also acts as an inhibitor of alpha-amylases secreted by competitors in the natural environment. Prompted by the structural similarity between acarbose and maltotetraose, the effects of acarbose on the metabolism of maltose and maltodextrins in whole cells of E. coli and on individual components of the maltose / maltodextrin system were studied. The results demonstrate that acarbose is efficiently transported but not metabolized by E. coli due to its ...
https://edoc.hu-berlin.de/handle/18452/15980?C=M
Acarbose - WikipediaAcarbose - Wikipedia
Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase (Bayer AG). It is cheap and popular in China, but not in the U.S. One physician explains the use in the U.S. is limited because it is not potent enough to justify the side effects of diarrhea and flatulence. However, a recent large study concludes acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes. A possible explanation for the differing opinions is an observation that acarbose is significantly more effective in patients eating a relatively high carbohydrate Eastern diet. It is a starch blocker, and inhibits alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. It is composed of an acarviosin moiety with a maltose at the reducing terminus. Acarbose ...
https://en.wikipedia.org/wiki/Acarbose
Acarbose Medication - Uses, Side Effects and Precautions of AcarboseAcarbose Medication - Uses, Side Effects and Precautions of Acarbose
In general, though, Acarbose should be taken three times daily at the start (with the first bite) of each main meal. Acarbose should be started at a low dose, with gradual dose escalation as described below, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. Do not take more or less of Acarbose than directed by your doctor ...
http://www.health-care-information.org/drugs/Acarbose.html
acarbose
Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. Acarbose is used to treat type 2 diabetes. Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Acarbose may also be used for purposes not listed in this medication guide.
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Acarbose is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.. DOSAGE Take exactly as prescribed by your doctor.. STORAGE. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.. MORE INFO. Active Ingredient: Acarbose. PRECOSE is available as 25 mg, 50 mg and 100 mg pills for oral use. The inactive ingredients are starch, microcrystalline cellulose, magnesium stearate, and colloidal silicon dioxide.. SAFETY INFORMATION. Do not use this medication if you are allergic to acarbose, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You also should not use acarbose if you have ...
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Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS)Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS)
This study is a prospective randomized clinical trial to compare the endocrine and metabolic effects of two anti diabetic drugs (metformin vs. acarbose)
http://www.knowcancer.com/cancer-trials/NCT01279512/
Acarbose and Older Adults With Postprandial Hypotension - Full Text View - ClinicalTrials.govAcarbose and Older Adults With Postprandial Hypotension - Full Text View - ClinicalTrials.gov
Blocking the absorption of carbohydrates at the brush border of the small intestine with acarbose (an alpha-glucosidase inhibitor) seems a promising possibility as a potential therapeutic agent. Although designed as a second-line diabetes drug, this medication has very little risk of hypoglycemia in older adults. In fact the risk of hypoglycemia is extremely low even in patients concurrently taking concurrent hypoglycemia agents (including insulin), and there is almost no risk of hypoglycemia in subjects not on other diabetes medications. Acarbose suppresses postprandial glycemia by slowing small intestinal digestion and absorption of carbohydrate, and has been shown to slow gastric emptying Acarbose has yet to be examined in a prospective fashion in older adults, despite the prevalence of PPH in this patient population. Preliminary, pilot work done in our laboratory on older adults with PPH has demonstrated that the hypotensive response over 90 minutes to a standardized meal was significantly ...
https://clinicaltrials.gov/ct2/show/NCT01914133?recr=Open&cond=%22Hypotension%22&rank=12
A COMPARATIVE STUDY OF MIGLITOL AND ACARBOSE ADD ON THERAPY INTENDED FOR BETTER GLYCAEMIC CONTROL IN TYPE 2 DIABETES MELLITUS -...A COMPARATIVE STUDY OF MIGLITOL AND ACARBOSE ADD ON THERAPY INTENDED FOR BETTER GLYCAEMIC CONTROL IN TYPE 2 DIABETES MELLITUS -...
Conclusions: Type 2 Diabetes forms a significant share of the Diabetic load in India where cereals in the form of carbohydrates form the staple diet of most Indians. Thus α glucosidase inhibitors like Miglitol and acarbose are sure to play an important role as an add on therapy when first line drugs like sulphonylurea and biguanides fail to control the hyperglycaemia and they have minimum adverse effects, with more or less similar efficacy with Miglitol being better than Acarbose... Key words: Type 2 Diabetes Mellitus, Hyperglycaemia, PPBS, HbA1c, Miglitol, Acarbose ...
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Acarbose was statistically significantly different from placebo at all doses with respect to effect on one-hour postprandial plasma glucose.. **The 300 mg t.i.d. acarbose regimen was superior to lower doses, but there were no statistically significant differences from 50 to 200 mg t.i.d. Clinical Experience in Type 2 Diabetes Mellitus Patients on Monotherapy, or in Combination with Sulfonylureas, Metformin or Insulin: acarbose was studied as monotherapy and as combination therapy to sulfonylurea, metformin, or insulin treatment. The treatment effects on HbA1c levels and one-hour postprandial glucose levels are summarized for four placebo-controlled, double-blind, randomized studies conducted in the United States in Tables 2 and 3, respectively. The placebo-subtracted treatment differences, which are summarized below, were statistically significant for both variables in all of these studies.. Study 1 (n=109) involved patients on background treatment with diet only. The mean effect of the addition ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6fb339f5-a3c5-4069-bd39-fc2c28e677ea
Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.govEfficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
https://clinicaltrials.gov/ct2/show/study/NCT01316861?view=record
ACARBOSA 50MG 30 TABS
Acarbose Generic Name: acarbose (ah KAR bose) Brand Names: Precose, Glucoobay What is acarbose? Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. Acarbose is used to treat type 2 diabetes. Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Acarbose may also be used for other purposes.. Please consult your medicial doctor for more information.. ...
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Acarbose (Oral Route) Description and Brand Names - Mayo ClinicAcarbose (Oral Route) Description and Brand Names - Mayo Clinic
Acarbose is used to treat type 2 diabetes. Normally, your pancreas releases insulin into the blood stream after you eat. Insulin is used by all the cells in your body to help turn the food you eat into energy. This is done by using glucose (sugar) in the blood as quick energy. When you have type 2 diabetes, insulin is still produced by your pancreas, but the amount of insulin produced may not be enough or your body may not be using it properly and you may still need more. Because of this, the insulin is not able to lower your blood sugar properly and you will have too much sugar in your blood. Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. It may be used alone or in combination with another type of oral diabetes medicine called a sulfonylurea. ...
https://www.mayoclinic.org/drugs-supplements/acarbose-oral-route/description/drg-20067949
Acarbose - treating Type 2 diabetesAcarbose - treating Type 2 diabetes
In book, A Quick Understanding on What Doctors Are Prescribing: Pharmacology for Everyday People & Finding Alternative Medications , it described that acarbose works by competiting against carbohydrates found in food supposedly binding to enzyme in order to be digested, but now the place of binding is blocked by acarbose. As a result, less carbohydrate will be broken down into glucose molecules and sugar level in the blood will not be dramatically increased ...
http://www.arthurwiz.com/health/acarbose-treating-type-2-diabetes
Acarbose | Define Acarbose at Dictionary.comAcarbose | Define Acarbose at Dictionary.com
Acarbose definition, a drug, C 25 H 43 NO 18 , used in the treatment of non-insulin-dependent diabetes: lowers blood sugar by inhibiting the enzymes that aid in starch and disaccharide digestion. See more.
http://www.dictionary.com/browse/acarbose
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Postprandial hypotension (PPH) is a common condition that occurs primarily in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the effectiveness of acarbose for PPH; it also investigated possible mechanisms behind PPH development. This single-blind, randomized controlled trial included 91 elderly patients with T2DM, aged between 60 and 80 years, who were inpatients at Beijing Hospital between March 2012 and November 2014. The patients were included into one of three groups: Group A, patients with T2DM without PPH; Group B, patients with T2DM with PPH receiving placebo; and Group C, patients with T2DM with PPH receiving acarbose. After an overnight fast, patients received a single dose of acarbose (100 mg) or placebo and then consumed a standardized 450 kcal meal. Blood pressure, glucose levels, heart rate (HR), and catecholamine levels were evaluated. Acarbose ameliorated PPH as determined by significant improvements in the duration and maximal fall in blood ...
http://jim.bmj.com/content/65/4/772
Understanding the effects of a calorie restriction mimetic on renal cancer progression and CD8 T cell immunity | The Journal of...Understanding the effects of a calorie restriction mimetic on renal cancer progression and CD8 T cell immunity | The Journal of...
Metastatic renal cell carcinoma (RCC) exhibits high mortality rates and chemotherapeutic resistance. Immune-based therapies, including high-dose IL-2 and anti-PD1, are efficacious in ~20% of patients; however, both are associated with substantial toxicity. This highlights the need for additional research aimed at improving response rates while also limiting toxicity. Previous findings by other groups have demonstrated that nutrient deprivation prior to chemotherapy reduces treatment toxicity and may improve therapeutic efficacy in cancer patients. Recent murine research shows that diets containing calorie restriction mimetics (CRMs) can recapitulate these beneficial effects by enhancing anti-cancer immunity. Here, we examined the impact of the alpha-glucosidase inhibitor acarbose, a potential CRM, on renal tumor burden and immune profiles. BALB/c mice were fed an acarbose-containing diet or macronutrient-matched control diet for 4 weeks prior to challenge with syngeneic Renca renal carcinoma ...
http://www.jimmunol.org/content/198/1_Supplement/76.12
Cardiology 2018 : Impact of Acarbose on the Serum YKL-40 Concentrations of Coronary Heart Disease Patients with Impaired...Cardiology 2018 : Impact of Acarbose on the Serum YKL-40 Concentrations of Coronary Heart Disease Patients with Impaired...
Background: YKL-40 is involved in inflammation and endothelial dysfunction, and associated with diabetes and atherosclerosis disease. In the present s..
https://www.alliedacademies.org/abstract/cardiology-2018--impact-of-acarbose-on-the-serum-ykl40-concentrations-of-coronary-heart-disease-patients-with-impaired-glucose-tol-12812.html
Dokument bez názvuDokument bez názvu
Mushrooms are a low calorie food with very little fat and are highly suitable for obese persons. The objective of the present investigation was to study the interaction of aqueous extract of P. pulmonarius (called PP-aqu) with acarbose on serum glucose levels, and on the oral glucose tolerance test (OGTT) in alloxan induced diabetic mice. PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination were administered orally in alloxan (70 mg/kg i.v.) induced diabetic mice. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimation at 7, 14, 21 and 28 days and recording of the body weights of the mice. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic mice half an hour after pre-treatment with PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination. Serum glucose levels were estimated 30 min prior to glucose ...
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Sodium in the structure of Structure of Bacillus Halmapalus Alpha-Amylase, Crystallized With the Substrate Analogue Acarbose...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 2gjp: Structure of Bacillus Halmapalus Alpha-Amylase, Crystallized With the Substrate Analogue Acarbose and Maltose
http://sodium.atomistry.com/pdb2gjp.html
The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus. A multicenter controlled...The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus. A multicenter controlled...
Acarbose improved long-term glycemic control in patients with non-insulin-dependent diabetes mellitus regardless of concomitant antidiabetic medication.
https://pubmed.ncbi.nlm.nih.gov/7734015/?dopt=Abstract
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Side Effects of Acarbose
This eMedTV Web page discusses some potential side effects of acarbose -- which can include gas, abdominal pain (or stomach pain), and diarrhea. This page also lists some serious side effects that you should report to your healthcare provider.
http://endocrine-system.emedtv.com/acarbose/side-effects-of-acarbose-p2.html
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Acarbose Dosage Guide with Precautions - Drugs.comAcarbose Dosage Guide with Precautions - Drugs.com
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Acarbose: Dosage, Mechanism/Onset of Action, Half-Life - Medicine.comAcarbose: Dosage, Mechanism/Onset of Action, Half-Life - Medicine.com
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RCSB PDB - 3BAY: N298S Variant of Human Pancreatic Alpha-Amylase in Complex with Nitrate and AcarboseRCSB PDB - 3BAY: N298S Variant of Human Pancreatic Alpha-Amylase in Complex with Nitrate and Acarbose
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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DAILY QUIZ- 16 - Pharmacognize Blog
Q1. Potency of action of a) Miglitol is six times higher than that of acarbose b) Acarbose is more than that of miglitol c) Miglitol and acarbose is equa
http://pharmacognizeblog.com/2016/11/06/daily-quiz-16/
AcarboseAcarbose
In nature, acarbose is synthesized by soil bacteria Actinoplanes sp through its precursor valienamine. And acarbose is also ... The microbiome-derived acarbose kinases are also specific to phosphorylate and inactivate acarbose. The molecular modeling ... "Acarbose". MedlinePlus Drug Information. "Acarbose: hepatitis: France, Spain". WHO Pharmaceuticals Newsletter. 1999. Archived ... acarbose was shown to extend the lifespan of female mice by 5% and of male mice by 22%. Acarbose degradation is the unique ...
https://en.wikipedia.org/wiki/Acarbose
List of drugs: GList of drugs: G
Redirects to acarbose. Glucohexal (Hexal Australia) [Au]. Redirects to metformin. Glucophage (Sanofi) glucosamine (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_G
List of drugs: Prb-PrnList of drugs: Prb-Prn
Precef preclamol (INN) Precose (Bayer AG). Redirects to acarbose. Pred-G Pred Predair Predamide prednazate (INN) prednazoline ( ...
https://en.wikipedia.org/wiki/List_of_drugs:_Prb–Prn
Anti-obesity medicationAnti-obesity medication
"acarbose - oral, Precose". MedicineNet. Archived from the original on 1 February 2014. Retrieved 27 January 2014. "Peptimmune ... A similar medication designed for patients with Type 2 diabetes is Acarbose; which partially blocks absorption of carbohydrates ...
https://en.wikipedia.org/wiki/Anti-obesity_medication
Alpha-glucosidase inhibitorAlpha-glucosidase inhibitor
Miglitol is fairly well absorbed by the body, as opposed to acarbose. Moreover, acarbose inhibits pancreatic alpha-amylase in ... there are subtle differences between acarbose and miglitol. Acarbose is an oligosaccharide, whereas miglitol resembles a ... Kim TJ, Kim MJ, Kim BC, Kim JC, Cheong TK, Kim JW, Park KH (April 1999). "Modes of action of acarbose hydrolysis and ... Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha- ...
https://en.wikipedia.org/wiki/Alpha-glucosidase_inhibitor
ValienamineValienamine
June 2002). "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the ... Valienamine is a C-7 aminocyclitol found as a substructure of pseudooligosaccharides such as the antidiabetic drug acarbose and ... Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes Treatment". Clinical Drug Investigation. 22 ...
https://en.wikipedia.org/wiki/Valienamine
GlycomimeticGlycomimetic
Acarbose is an enzyme inhibitor that is used as a drug against type 2 diabetes. Miglustat is an iminosugar in which the ring ... Tamiflu is an enzyme inhibitor that blocks the action of influenza virus neuraminidases (sialidases). Acarbose is a ...
https://en.wikipedia.org/wiki/Glycomimetic
ActinoplanesActinoplanes
Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes Treatment". Clinical Drug Investigation. 22 ... a precursor to the antidiabetic drug acarbose and to the antibiotic validamycin), teicoplanin, and ramoplanin. Actinoplanes ...
https://en.wikipedia.org/wiki/Actinoplanes
Beano (dietary supplement)Beano (dietary supplement)
Another study indicates it may interfere with the diabetic medication acarbose. Beano was developed in 1990 by Alan Kligerman ... Lettieri JT, Dain B (1998). "Effects of beano on the tolerability and pharmacodynamics of acarbose". Clin Ther. 20 (3): 497-504 ...
https://en.wikipedia.org/wiki/Beano_(dietary_supplement)
Alpha-glucosidaseAlpha-glucosidase
Acarbose may be able to prevent the development of diabetic symptoms. Hence, α-glucosidase inhibitors (like acarbose) are used ... Diabetes: Acarbose, an α-glucosidase inhibitor, competitively and reversibly inhibits α-glucosidase in the intestines. This ...
https://en.wikipedia.org/wiki/Alpha-glucosidase
CyclomaltodextrinaseCyclomaltodextrinase
The cyclomaltodextrinase is capable of degradation of acarbose to glucose and acarviosine-glucose. As of late 2007, two ... This enzyme participates in starch and sucrose metabolism and acarbose degradation. ... "Functional expression and enzymatic characterization of Lactobacillus plantarum cyclomaltodextrinase catalyzing novel acarbose ...
https://en.wikipedia.org/wiki/Cyclomaltodextrinase
MiglitolMiglitol
In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not ...
https://en.wikipedia.org/wiki/Miglitol
AcarviosinAcarviosin
... is part of the potent α-amylase inhibitor acarbose and its derivatives. Acarviosin is a product of the degradation ... of acarbose by gut microbiota, the glycoside hydrolase from gut bacteria Lactobacillus plantarum is able to hydrolyze acarbose ... "Functional expression and enzymatic characterization of Lactobacillus plantarum cyclomaltodextrinase catalyzing novel acarbose ...
https://en.wikipedia.org/wiki/Acarviosin
Glycoside hydrolase family 15Glycoside hydrolase family 15
The 3D structure of the pseudo-tetrasaccharide acarbose complexed with glucoamylase II(471) from Aspergillus awamori var. X100 ... Aleshin AE, Firsov LM, Honzatko RB (June 1994). "Refined structure for the complex of acarbose with glucoamylase from ...
https://en.wikipedia.org/wiki/Glycoside_hydrolase_family_15
Glucan 1,4-alpha-maltohydrolaseGlucan 1,4-alpha-maltohydrolase
Kim TJ, Kim MJ, Kim BC, Kim JC, Cheong TK, Kim JW, Park KH (April 1999). "Modes of action of acarbose hydrolysis and ... and Geobacillus thermoleovorans are able to degrade acarbose to glucose and acarviosine-glucose. Diderichsen B, Christiansen L ... "Molecular and enzymatic characterization of a maltogenic amylase that hydrolyzes and transglycosylates acarbose". European ...
https://en.wikipedia.org/wiki/Glucan_1,4-alpha-maltohydrolase
Sucrase-isomaltaseSucrase-isomaltase
Within the -1 subsite, isomaltose's non-reducing glucose ring was aligned to that of acarbose. Not only has the structure of ...
https://en.wikipedia.org/wiki/Sucrase-isomaltase
PrediabetesPrediabetes
Metformin and acarbose help prevent the development of prediabetes, and also have a good safety profile. Evidence also supports ...
https://en.wikipedia.org/wiki/Prediabetes
Life extensionLife extension
... acarbose, spermidine and NAD+ enhancers. Many prolongevity drugs are synthetic alternatives or potential complements to ...
https://en.wikipedia.org/wiki/Life_extension
GlucosidasesGlucosidases
Alpha-glucosidases are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type ...
https://en.wikipedia.org/wiki/Glucosidases
Maltase-glucoamylaseMaltase-glucoamylase
Tuğrul S, Kutlu T, Pekin O, Bağlam E, Kiyak H, Oral O (October 2008). "Clinical, endocrine, and metabolic effects of acarbose, ...
https://en.wikipedia.org/wiki/Maltase-glucoamylase
NeopullulanaseNeopullulanase
"Complex structures of Thermoactinomyces vulgaris R-47 alpha-amylase 2 with acarbose and cyclodextrins demonstrate the multiple ...
https://en.wikipedia.org/wiki/Neopullulanase
VogliboseVoglibose
There are three major drugs which belong to this class, acarbose, miglitol and voglibose, of which voglibose is the newest. ...
https://en.wikipedia.org/wiki/Voglibose
Aquatic plantAquatic plant
... prepared from the leaf of Ludwigia adscendens exhibits alpha-glucosidase inhibitory activity more potent than that of acarbose ...
https://en.wikipedia.org/wiki/Aquatic_plant
Glycoside hydrolaseGlycoside hydrolase
Inhibitors that are in clinical use include the anti-diabetic drugs acarbose and miglitol, and the antiviral drugs oseltamivir ...
https://en.wikipedia.org/wiki/Glycoside_hydrolase
Diabetes medicationDiabetes medication
Typical reductions in glycated hemoglobin (A1C) values are 0.5-1.0%. miglitol acarbose voglibose These medications are rarely ... Acarbose Meglitinides - nateglinide Combination of sulfonylureas plus metformin - known by generic names of the two drugs No ...
https://en.wikipedia.org/wiki/Diabetes_medication
17α-Estradiol17α-Estradiol
"Sex differences in lifespan extension with acarbose and 17‐α estradiol: gonadal hormones underlie male‐specific improvements in ...
https://en.wikipedia.org/wiki/17α-Estradiol
Actinoplanes utahensisActinoplanes utahensis
... is a species of bacteria and a source of the drug acarbose, an alpha-glucosidase inhibitor used in the ...
https://en.wikipedia.org/wiki/Actinoplanes_utahensis
AminocyclitolAminocyclitol
sedoheptulose 7-phosphate derived C7N aminocyclitol natural products This class includes acarbose, validamycin, validoxylamine ... such as acarbose, validamycin A, salbostatin, cetoniacytone A, and pyralomicin 1a. 2-epi-5-epi-valiolone synthase (EEVS), one ... "Biosynthesis of the C7-cyclitol Moiety of Acarbose inActinoplanes Species SE50/110 7-O-PHOSPHORYLATION OF THE INITIAL CYCLITOL ... Synthase Related to 3-Dehydroquinate Synthases and Is Involved in the Biosynthesis of the α-Glucosidase Inhibitor Acarbose". ...
https://en.wikipedia.org/wiki/Aminocyclitol
IndigestionIndigestion
... acarbose, metformin, Alpha-glucosidase inhibitor, amylin analogs, GLP-1 receptor antagonists), antihypertensive medications ( ...
https://en.wikipedia.org/wiki/Indigestion
List of MeSH codes (D09)List of MeSH codes (D09)
... acarbose MeSH D09.698.629.802.700 - raffinose MeSH D09.698.718.200 - bacterial capsules MeSH D09.698.718.220 - bambermycins ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D09)
Acarbose: MedlinePlus Drug InformationAcarbose: MedlinePlus Drug Information
Acarbose: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking acarbose,. *tell your doctor and pharmacist if you are allergic to acarbose or any other drugs. ... Continue to take acarbose even if you feel well. Do not stop taking acarbose without talking to your doctor. ... Acarbose comes as a tablet to take by mouth. It is usually taken three times a day. It is very important to take each dose with ...
https://medlineplus.gov/druginfo/meds/a696015.html
Foods to Avoid When Taking AcarboseFoods to Avoid When Taking Acarbose
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Acarbose delays development of type 2 diabetesAcarbose delays development of type 2 diabetes
Acarbose delays the development of type 2 diabetes in patients with impaired glucose tolerance. The alpha-glucosidase inhibitor ... Acarbose cuts down on this hyperglycemia. This may be one of the mechanisms involved in the prevention of diabetes and, it is ... They add that acarbose probably prevents the development of diabetes by decreasing the postprandial rise in blood glucose. This ... London, UK - The alpha-glucosidase inhibitor acarbose delays the development of type 2 diabetes in patients with impaired ...
https://www.medscape.com/viewarticle/784305
Acarbose - HealthLibrary
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Acarbose Offers No CVD Protection in ACE, but May Cut Diabetes RiskAcarbose Offers No CVD Protection in ACE, but May Cut Diabetes Risk
A study of acarbose was conducted in a Chinese population with impaired glucose tolerance and established cardiovascular ... Acarbose, the first α-glucosidase inhibitor approved for the treatment of type 2 diabetes in the 1990s, acts to impede the ... "It [acarbose] might work in people with diabetes, but thats not what this trial addressed," he continued. "Its strictly a ... Cite this: Acarbose Offers No CVD Protection in ACE, but May Cut Diabetes Risk - Medscape - Sep 14, 2017. ...
http://www.medscape.com/viewarticle/885675
Acarbose (Oral Route) Precautions - 妙佑医疗国际Acarbose (Oral Route) Precautions - 妙佑医疗国际
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Global Acarbose API Market Research 2021: Leading Players, Analytical Assessment and Future Scope Analysis by 2026 - PharmiWeb...Global Acarbose API Market Research 2021: Leading Players, Analytical Assessment and Future Scope Analysis by 2026 - PharmiWeb...
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PrecoseGlucobayStop taking aAlpha-glucosidaInhibitorPostprandial50mgTabletMetforminCarbohydratesReduced the incidenceGlucose2021InsulinHypoglycemiaMedicationPlaceboMedicinesTypeInhibitorsGenericHyperglycemiaDiabeticGastrointestinalDrugsDoseInteractionsInflammatoryMedicationsBlood sugar2017AbsorptionEffectivenessDietsPregnantTreatmentDoctorPeoplePrescriptionPatientsLiver
Precose3
  • LISBON, PORTUGAL - The α-glucosidase inhibitor acarbose ( Glucobay/Precose/Prandase , Bayer) reduces the incidence of diabetes but not of major cardiovascular events among Chinese patients with established heart disease and impaired glucose tolerance (IGT), new research indicates. (medscape.com)
  • It's the parent group of two medicines: Acarbose Precose and Miglitol Glyset. (ziprx.ca)
  • In fact, vinegar's effects may be similar to those of the blood sugar -- lowering medication acarbose (Precose). (go.com)
Glucobay12
  • By aiding the regulation of glucose, Glucobay Acarbose combats diabetes, weight gain and aging. (optimalhealth-products.com)
  • Branded as Glucobay Acarbose, it helps diabetes sufferers live more normal lives. (optimalhealth-products.com)
  • Glucobay Acarbose taken daily helps you feel full for longer by providing a more stable supply of essential blood sugars. (optimalhealth-products.com)
  • Glucobay Acarbose also assists diabetics with weight loss. (optimalhealth-products.com)
  • Glucobay Acarbose is your essential treatment because it helps regulate glucose, your body's preferred source of energy. (optimalhealth-products.com)
  • Glucobay Acarbose will help if you have Type 1 diabetes which results from the body's inability to produce insulin. (optimalhealth-products.com)
  • Glucobay Acarbose is equally essential if you suffer Type 2 diabetes due to insulin resistance. (optimalhealth-products.com)
  • Glucobay Acarbose is ideal for Type 2 sufferers, by helping to reduce the risks of heart disease and strokes, kidney failure, limb amputation and the onset of blindness. (optimalhealth-products.com)
  • Glucobay Acarbose can either be prescribed as a single therapy, or it can be used in conjunction with other treatments. (optimalhealth-products.com)
  • But by taking Glucobay Acarbose, we reduce our desire for glucose-rich foods. (optimalhealth-products.com)
  • For antiaging and appetite suppression, take one 50mg Glucobay Acarbose tablet one to three times daily. (optimalhealth-products.com)
  • Glucobay Acarbose delivers on many fronts: from combating diabetes, to weight loss support and promoting antiaging health, Acarbose is the answer. (optimalhealth-products.com)
Stop taking a3
  • Do not stop taking acarbose without talking to your doctor. (medlineplus.gov)
  • Your doctor may want you to stop taking acarbose for a short time if any of these situations affect you. (canadianjopharmacy.com)
  • Your doctor may want you to stop taking acarbose for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency. (medications.su)
Alpha-glucosida1
  • We examined the impact of acarbose, an alpha-glucosidase inhibitor, on incident diabetes and regression to normoglycemia in 6,522 Acarbose Cardiovascular Evaluation trial participants in China who had impaired glucose tolerance (IGT) and coronary heart disease (CHD). (figshare.com)
Inhibitor4
  • Acarbose, the first α-glucosidase inhibitor approved for the treatment of type 2 diabetes in the 1990s, acts to impede the absorption of carbohydrates and therefore works primarily to reduce postprandial rises in glucose. (medscape.com)
  • The α-glucosidase inhibitor acarbose, which slows carbohydrate digestion and blunts postprandial rises in plasma glucose, has long been used to treat patients with type 2 diabetes or glucose intolerance. (bmj.com)
  • The present study evaluated whether the combination of the α-glucosidase inhibitor, acarbose, and basal insulin improved blood glucose control under daily-life treatment conditions in a large sample of Korean patients. (elsevier.com)
  • Acarbose, an α-glucosidase inhibitor that lowers postprandial blood glucose, has been shown to reduce T2DM risk by 25%, and possibly cardiovascular risk in impaired glucose tolerance subjects without cardiovascular disease. (ox.ac.uk)
Postprandial5
  • Dr Li told Medscape Medical News that he prescribes acarbose for some of his type 2 diabetes patients, particularly those who are newly diagnosed with only mild glycemic elevation and for whom postprandial blood glucose levels are their primary problem: "It's very useful for them. (medscape.com)
  • Acarbose treatment can favourably affect blood pressure, serum lipids, platelet aggregation, progression of carotid intima-media thickness and postprandial endothelial dysfunction. (bmj.com)
  • 3 Clinical doses of acarbose ingested with meals notably blunt the postprandial increase in serum glucose, a well-documented predictor of macrovascular and microvascular complications in diabetics, and of macrovascular risk in non-diabetics. (bmj.com)
  • 4 , 5 A Cochrane meta-analysis found that, on average, acarbose therapy lowers glycated haemoglobin (HbA1c) levels by 0.8%, and reduces the postprandial increase in plasma glucose by 2.3 mM. 6 Glycaemic control benefits of acarbose therapy tend to be greater in Asian clinical trials than in Western ones, likely because Asians tend to consume diets higher in carbohydrates. (bmj.com)
  • C. genistoides enriched in xanthones and benzophenones show potential in reducing the effective dose of acarbose required to prevent postprandial hyperglycaemia. (greenmedinfo.com)
50mg1
Tablet1
Metformin3
  • Like metformin, acarbose tends to aid weight control, postpone onset of diabetes and decrease risk for cardiovascular events. (bmj.com)
  • After admission, the patient was found to have type 2 diabetes mellitus, for which acarbose and metformin were prescribed. (cdc.gov)
  • Although pharmacotherapy with such drugs as metformin, acarbose, orlistat, and thiazolidinediones can reduce risk of type 2 diabetes ( 3 ), their cost and potential adverse effects can be objectionable to patients who do not yet have an actual disease ( 4 ). (cdc.gov)
Carbohydrates2
  • It works in the small intestine where Acarbose inhibits the actions of enzymes that breakdown complex carbohydrates into simpler sugars such as glucose. (optimalhealth-products.com)
  • Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. (canadianjopharmacy.com)
Reduced the incidence2
  • The rationale for the ACE trial had come from the 2002 Study To Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM), which showed that acarbose reduced the incidence of type 2 diabetes by 25% in people with IGT. (medscape.com)
  • Acarbose reduced the incidence of diabetes and promoted regression to normoglycemia in Chinese people with IGT and CHD. (figshare.com)
Glucose8
  • Acarbose works by slowing the action of certain chemicals that break down food to release glucose (sugar) into your blood. (medlineplus.gov)
  • As well, patients on acarbose were more likely to have their impaired glucose tolerance revert back to normal glucose tolerance than patients on placebo, the investigators report. (medscape.com)
  • It could also possibly explain, at least in part, why acarbose treatment was associated with an increased reversion to normal glucose tolerance," Chiasson et al write. (medscape.com)
  • Acarbose is essential if your body does not produce insulin, or your natural insulin does not unlock glucose properly - often when you are diabetic. (optimalhealth-products.com)
  • Acarbose reduces food cravings by slowing the absorption of glucose and reducing sugar highs. (optimalhealth-products.com)
  • Acarbose is important if your body does not produce insulin, or your natural insulin does not unlock glucose properly. (optimalhealth-products.com)
  • 7 Gastrointestinal side effects of acarbose-reflecting carbohydrate malabsorption-are fairly common when initiating therapy, but tend to lessen over time as the distal intestine upregulates its capacity to absorb glucose. (bmj.com)
  • Conclusions: Combination therapy of basal insulin and acarbose in patients with type 2 diabetes improved glucose control, and had no drug-specific safety concerns, suggesting that the treatment might benefit individuals who cannot control blood glucose with basal insulin alone. (elsevier.com)
20212
  • Global Acarbose API Market Research 2021: Leading Players. (pharmiweb.com)
  • Global Acarbose API Market Growth 2021-2026 recently released by MRInsights.biz include historical and projected data for the industry, as well as statistics on global socio-economic data. (pharmiweb.com)
Insulin7
  • When used in combination with insulin or other medications used to treat diabetes, acarbose may cause excessive lowering of blood sugar levels. (medlineplus.gov)
  • Acarbose can also counter aging caused by excessive insulin in our bodies. (optimalhealth-products.com)
  • Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. (canadianjopharmacy.com)
  • A total of 539 patients with type 2 diabetes who were treated with basal insulin and additional acarbose were enrolled and followed up for 20 weeks. (elsevier.com)
  • In the satisfaction evaluation, 79.0% of physicians and 77.3% of patients were 'very satisfied' or 'satisfied' with the combined basal insulin and acarbose therapy. (elsevier.com)
  • If you take acarbose with insulin or other diabetes medications, your blood sugar could get too low. (medications.su)
  • Do not use this medication if you are allergic to acarbose, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). (medications.su)
Hypoglycemia1
  • Acarbose does not cause hypoglycemia (low blood sugar). (mayoclinic.org)
Medication1
  • And regarding the CVD findings, Dr Bennett said, "Clearly, acarbose is not a good medication for secondary prevention of cardiovascular disease in patients with IGT. (medscape.com)
Placebo5
  • Patients were randomized to acarbose 3 times a day (n=682) or to placebo (n=686). (medscape.com)
  • In the randomized, double-blind, placebo-controlled phase 4 ACE trial of 6522 Chinese adults with IGT and cardiovascular disease, there was no difference in the incidence of a composite 5-point major adverse cardiovascular event (MACE) score between those who took 50 mg of acarbose three times daily or placebo for a median of 5 years. (medscape.com)
  • Participants were randomly assigned to acarbose or placebo and followed with four-monthly FPGs and annual OGTTs. (figshare.com)
  • Incident diabetes was less frequent with acarbose, compared with placebo, being 3.2 and 3.8 per 100 person-years respectively (rate ratio (RR) 0.82, 95%CI 0.71-0.94, p=0.005), with no evidence of differential effects within the predefined subgroups after accounting for multiple testing. (figshare.com)
  • The likelihood of remaining in normoglycemic regression did not differ between acarbose and placebo groups (P=0.41). (figshare.com)
Medicines1
  • Other medicines-Do not take other medicines during the time you are taking acarbose unless they have been discussed with your doctor. (mayoclinic.org)
Type7
  • Cite this: Acarbose staves off type 2 diabetes - Medscape - Jun 13, 2002. (medscape.com)
  • However, low blood sugar can occur if you take acarbose with another type of diabetes medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting. (mayoclinic.org)
  • It is possible that Acarbose may benefit people suffering pre-diabetes - the precursor to Type 2. (optimalhealth-products.com)
  • Acarbose may also help people suffering pre-diabetes - the precursor to Type 2. (optimalhealth-products.com)
  • Acarbose is used to treat type 2 diabetes. (canadianjopharmacy.com)
  • Global Brand Variant Acarbose 25 mg tablets are used in controlling high blood sugar in people with type 2 diabetes. (daynightdrugs.com)
  • The Acarbose API market report has been segregated into distinct categories such as product type, application, end-user, and region. (ame-net.com)
Inhibitors1
Generic2
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  • You can check the Generic acarbose 25 mg price on our website. (daynightdrugs.com)
Hyperglycemia1
Diabetic1
  • Synergistic cardioprotective ability of co-administration of Moringa supplemented diets and acarbose in diabetic cardiomyopathy involves attenuation of cholinergic, purinergic, monoaminergic, renin-angiotensin system, and antioxidant pathways. (bvsalud.org)
Gastrointestinal1
  • To keep the known gastrointestinal side effects of acarbose (ie flatulence, diarrhea , abdominal cramps) to a minimum, the drug was started at 50 mg per day and increased gradually to a maximum of 100 mg 3 times per day or to the maximum tolerated dose. (medscape.com)
Drugs2
  • tell your doctor and pharmacist if you are allergic to acarbose or any other drugs. (medlineplus.gov)
  • eHealthMe is studying from 4,047 Acarbose users for its effectiveness, alternative drugs and more. (ehealthme.com)
Dose1
  • Ask your doctor how to adjust your acarbose dose if needed. (medications.su)
Interactions3
  • Drug interactions are reported among people who take Acarbose and Farxiga. (ehealthme.com)
  • The phase IV clinical study analyzes what interactions people who take Acarbose and Farxiga have. (ehealthme.com)
  • 9 people who take Acarbose and Farxiga together, and have interactions are studied. (ehealthme.com)
Inflammatory1
Medications2
  • It is important that you and other members of your household understand this difference between acarbose and other medications used to treat diabetes. (medlineplus.gov)
  • Acarbose is used to treat diabetes in combination with diet and other medications. (medindia.net)
Blood sugar4
  • Because acarbose blocks the breakdown of table sugar and other complex sugars, fruit juice or other products containing these sugars will not help to increase blood sugar. (medlineplus.gov)
  • Acarbose defends your body by reducing blood sugar peaks. (optimalhealth-products.com)
  • While you are taking acarbose, candy or table sugar (sucrose) may not work as well as dextrose in quickly raising your blood sugar. (canadianjopharmacy.com)
  • Acarbose is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. (medications.su)
20171
  • Findings from the Acarbose Cardiovascular Evaluation (ACE) trial were presented September 13 here at the European Association for the Study of Diabetes (EASD) 2017 Annual Meeting by several members of the research team, led by Rury R Holman, director of the University of Oxford Diabetes Trials Unit, United Kingdom. (medscape.com)
Absorption1
  • The benefits of acarbose are likely mimicked by diets featuring slowly-digested 'lente' carbohydrate, and by certain nutraceuticals which can slow carbohydrate absorption. (bmj.com)
Effectiveness1
  • More than 100 studies have proven the effectiveness of Acarbose - in particular its ability to help delay the progression of diabetes and fight against cardiovascular complications. (optimalhealth-products.com)
Diets1
  • Here, we evaluated the combinatorial effect of Moringa leaf (ML) and seed (MS) supplemented diets plus acarbose (ACA) on cardiac acetylcholinesterase ( AChE ), adenosine triphosphatase ( ATPase ), adenosine deaminase (ADA), monoamine oxidase ( MAO ), arginase , angiotensin -I converting enzyme (ACE), and lactate dehydrogenase (LDH) activities, thiobarbituric acid reactive species ( TBARS ), and thiols levels. (bvsalud.org)
Pregnant1
  • If you become pregnant while taking acarbose, call your doctor. (medlineplus.gov)
Treatment1
  • Acarbose is only part of a complete program of treatment that also includes diet, exercise, and weight control. (canadianjopharmacy.com)
Doctor2
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking acarbose. (medlineplus.gov)
  • Ask your doctor about the safe use of alcoholic beverages while you are taking acarbose. (medlineplus.gov)
People1
  • It [acarbose] might work in people with diabetes, but that's not what this trial addressed," he continued. (medscape.com)
Prescription1
Patients1
  • It is the weight loss system physicians and patients trust as the number one Acarbose diabetes therapy. (optimalhealth-products.com)
Liver1
  • Indeed, GLP-1 exerts protective effects on vascular endothelium, the liver, the heart, pancreatic β cells, and the brain which can rationalise many of the benefits reported with acarbose. (bmj.com)
Type 2 Diabetes Mellitus Medication: Antidiabetics, Biguanides, Antidiabetics, Sulfonylureas, Antidiabetics, Meglitinide...
Type 2 Diabetes Mellitus Medication: Antidiabetics, Biguanides, Antidiabetics, Sulfonylureas, Antidiabetics, Meglitinide... (medscape.com)
(emedicine.medscape.com)
Acarbose (Oral Route) Precautions - 妙佑医疗国际
Acarbose (Oral Route) Precautions - 妙佑医疗国际 (mayoclinic.org)
A-Z Drug Index for Prescription and OTC Medications
A-Z Drug Index for Prescription and OTC Medications (medindia.net)
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Acarbose Offers No CVD Protection in ACE, but May Cut Diabetes Risk
Acarbose Offers No CVD Protection in ACE, but May Cut Diabetes Risk (medscape.com)
Type 2 Diabetes Mellitus Treatment & Management: Approach Considerations, Pharmacologic Therapy, Management of Glycemia
Type 2 Diabetes Mellitus Treatment & Management: Approach Considerations, Pharmacologic Therapy, Management of Glycemia (medscape.com)
Acarbose: MedlinePlus medicinas
Acarbose: MedlinePlus medicinas (medlineplus.gov)
Kardiovaskuläre Risikoreduktion: Antidiabetika statt HDL-Erhöhung?
Kardiovaskuläre Risikoreduktion: Antidiabetika statt HDL-Erhöhung? (medscape.com)
PDF] The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms | Semantic Scholar
PDF] The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms | Semantic Scholar (semanticscholar.org)
Polycystic ovary syndrome - References | BMJ Best Practice US
Polycystic ovary syndrome - References | BMJ Best Practice US (bestpractice.bmj.com)
Perioperative Management of the Diabetic Patient: Practice Essentials, Physiology of Glucose Metabolism, General Preoperative...
Perioperative Management of the Diabetic Patient: Practice Essentials, Physiology of Glucose Metabolism, General Preoperative... (emedicine.medscape.com)
Innovative tools for life science and biotech research - Toronto Research Chemicals | products for innovative research
Innovative tools for life science and biotech research - Toronto Research Chemicals | products for innovative research (trc-canada.com)
JCM | Free Full-Text | Pioglitazone Is Associated with Lower Major Adverse Cardiovascular and Cerebrovascular Events than DPP4...
JCM | Free Full-Text | Pioglitazone Is Associated with Lower Major Adverse Cardiovascular and Cerebrovascular Events than DPP4... (mdpi.com)
PCOS Clinical Research Trials | CenterWatch
PCOS Clinical Research Trials | CenterWatch (centerwatch.com)
Dumping Syndrome Treatment & Management: Medical Care, Surgical Care, Diet
Dumping Syndrome Treatment & Management: Medical Care, Surgical Care, Diet (medscape.com)
Diabetic Nephropathy Medication: Insulins, Sulfonylureas, Biguanides, Thiazolidinedione derivatives, Angiotensin-converting...
Diabetic Nephropathy Medication: Insulins, Sulfonylureas, Biguanides, Thiazolidinedione derivatives, Angiotensin-converting... (medscape.com)