An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.
Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.
Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.
Six-carbon pyranose sugars in which the OXYGEN is replaced by a NITROGEN atom.
Substances which lower blood glucose levels.
1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrolase. An enzyme system having both 4-alpha-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33) activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or another 1,4-alpha-D-glucan. As a glucosidase it catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-1,6-glucosidase activity is deficient in glycogen storage disease type III.
Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.
Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.
Enzymes that hydrolyze O-glucosyl-compounds. (Enzyme Nomenclature, 1992) EC 3.2.1.-.
An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.
A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.
A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
Pharmacy services accessed via electronic means.
Medicines that can be sold legally without a DRUG PRESCRIPTION.
Drugs that cannot be sold legally without a prescription.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.
Social welfare organizations with programs designed to assist individuals in need.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Characteristic events occurring in the ATMOSPHERE during the interactions and transformation of various atmospheric components and conditions.
Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.
Individuals referred to for expert or professional advice or services.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
A medical specialty concerned with maintaining health and providing medical care to children from birth to adolescence.
Institutions specializing in the care of cancer patients.
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Glucose in blood.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Inanimate objects that become enclosed in the body.
The production and movement of food items from point of origin to use or consumption.
Any substances taken in by the body that provide nourishment.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Manganese sulfate-dependent glycosylation of endogenous glycoproteins in human skeletal muscle is catalyzed by a nonglucose 6-P-dependent glycogen synthase and not glycogenin. (1/145)

Glycogenin, a Mn2+-dependent, self-glucosylating protein, is considered to catalyze the initial glucosyl transfer steps in glycogen biogenesis. To study the physiologic significance of this enzyme, measurements of glycogenin mediated glucose transfer to endogenous trichloroacetic acid precipitable material (protein-bound glycogen, i.e., glycoproteins) in human skeletal muscle were attempted. Although glycogenin protein was detected in muscle extracts, activity was not, even after exercise that resulted in marked glycogen depletion. Instead, a MnSO4-dependent glucose transfer to glycoproteins, inhibited by glycogen and UDP-pyridoxal (which do not affect glycogenin), and unaffected by CDP (a potent inhibitor of glycogenin), was consistently detected. MnSO4-dependent activity increased in concert with glycogen synthase fractional activity after prolonged exercise, and the MnSO4-dependent enzyme stimulated glucosylation of glycoproteins with molecular masses lower than those glucosylated by glucose 6-P-dependent glycogen synthase. Addition of purified glucose 6-P-dependent glycogen synthase to the muscle extract did not affect MnSO4-dependent glucose transfer, whereas glycogen synthase antibody completely abolished MnSO4-dependent activity. It is concluded that: (1) MnSO4-dependent glucose transfer to glycoproteins is catalyzed by a nonglucose 6-P-dependent form of glycogen synthase; (2) MnSO4-dependent glycogen synthase has a greater affinity for low molecular mass glycoproteins and may thus play a more important role than glucose 6-P-dependent glycogen synthase in the initial stages of glycogen biogenesis; and (3) glycogenin is generally inactive in human muscle in vivo.  (+info)

Modes of action of acarbose hydrolysis and transglycosylation catalyzed by a thermostable maltogenic amylase, the gene for which was cloned from a Thermus strain. (2/145)

A maltogenic amylase gene was cloned in Escherichia coli from a gram-negative thermophilic bacterium, Thermus strain IM6501. The gene encoded an enzyme (ThMA) with a molecular mass of 68 kDa which was expressed by the expression vector p6xHis119. The optimal temperature of ThMA was 60 degrees C, which was higher than those of other maltogenic amylases reported so far. Thermal inactivation kinetic analysis of ThMA indicated that it was stabilized in the presence of 10 mM EDTA. ThMA harbored both hydrolysis and transglycosylation activities. It hydrolyzed beta-cyclodextrin and starch mainly to maltose and pullulan to panose. ThMA not only hydrolyzed acarbose, an amylase inhibitor, to glucose and pseudotrisaccharide (PTS) but also transferred PTS to 17 sugar acceptors, including glucose, fructose, maltose, cellobiose, etc. Structural analysis of acarbose transfer products by using methylation, thin-layer chromatography, high-performance ion chromatography, and nuclear magnetic resonance indicated that PTS was transferred primarily to the C-6 of the acceptors and at lower degrees to the C-3 and/or C-4. The transglycosylation of sugar to methyl-alpha-D-glucopyranoside by forming an alpha-(1,3)-glycosidic linkage was demonstrated for the first time by using acarbose and ThMA. Kinetic analysis of the acarbose transfer products showed that the C-4 transfer product formed most rapidly but readily hydrolyzed, while the C-6 transfer product was stable and accumulated in the reaction mixture as the main product.  (+info)

The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. (3/145)

The putative biosynthetic gene cluster for the alpha-glucosidase inhibitor acarbose was identified in the producer Actinoplanes sp. 50/110 by cloning a DNA segment containing the conserved gene for dTDP-D-glucose 4,6-dehydratase, acbB. The two flanking genes were acbA (dTDP-D-glucose synthase) and acbC, encoding a protein with significant similarity to 3-dehydroquinate synthases (AroB proteins). The acbC gene was overexpressed heterologously in Streptomyces lividans 66, and the product was shown to be a C7-cyclitol synthase using sedo-heptulose 7-phosphate, but not ido-heptulose 7-phosphate, as its substrate. The cyclization product, 2-epi-5-epi-valiolone ((2S,3S,4S,5R)-5-(hydroxymethyl)cyclohexanon-2,3,4,5-tetrol), is a precursor of the valienamine moiety of acarbose. A possible five-step reaction mechanism is proposed for the cyclization reaction catalyzed by AcbC based on the recent analysis of the three-dimensional structure of a eukaryotic 3-dehydroquinate synthase domain (Carpenter, E. P., Hawkins, A. R., Frost, J. W., and Brown, K. A. (1998) Nature 394, 299-302).  (+info)

Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli. (4/145)

The pseudooligosaccharide acarbose is a potent inhibitor of amylases, glucosidases, and cyclodextrin glycosyltransferase and is clinically used for the treatment of so-called type II or insulin-independent diabetes. The compound consists of an unsaturated aminocyclitol, a deoxyhexose, and a maltose. The unsaturated aminocyclitol moiety (also called valienamine) is primarily responsible for the inhibition of glucosidases. Due to its structural similarity to maltotetraose, we have investigated whether acarbose is recognized as a substrate by the maltose/maltodextrin system of Escherichia coli. Acarbose at millimolar concentrations specifically affected the growth of E. coli K-12 on maltose as the sole source of carbon and energy. Uptake of radiolabeled maltose was competitively inhibited by acarbose, with a Ki of 1.1 microM. Maltose-grown cells transported radiolabeled acarbose, indicating that the compound is recognized as a substrate. Studying the interaction of acarbose with purified maltoporin in black lipid membranes revealed that the kinetics of acarbose binding to LamB is asymmetric. The on-rate of acarbose is approximately 30 times lower when the molecule enters the pore from the extracellular side than when it enters from the periplasmic side. Acarbose could not be utilized as a carbon source since the compound alone was not a substrate of amylomaltase (MalQ) and was only poorly attacked by maltodextrin glucosidase (MalZ).  (+info)

A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44) (5/145)

OBJECTIVE: To determine the degree to which alpha-glucosidase inhibitors, with their unique mode of action primarily reducing postprandial hyperglycemia, offer an additional therapeutic approach in the long-term treatment of type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied 1,946 patients (63% men) who were previously enrolled in the U.K. Prospective Diabetes Study (UKPDS). The patients were randomized to acarbose (n = 973), titrating to a maximum dose of 100 mg three times per day, or to matching placebo (n = 973). Mean +/- SD age was 59 +/- 9 years, body weight 84 +/- 17 kg, diabetes duration 7.6 +/- 2.9 years, median (interquartile range) HbA1c 7.9% (6.7-9.5), and fasting plasma glucose (FPG) 8.7 mmol/l (6.8-11.1). Fourteen percent of patients were treated with diet alone, 52% with monotherapy, and 34% with combined therapy. Patients were monitored in UKPDS clinics every 4 months for 3 years. The main outcome measures were HbA1c, FPG, body weight, compliance with study medication, incidence of side effects, and frequency of major clinical events. RESULTS: At 3 years, a lower proportion of patients were taking acarbose compared with placebo (39 vs. 58%, P < 0.0001), the main reasons for noncompliance being flatulence (30 vs. 12%, P < 0.0001) and diarrhea (16 vs. 8%, P < 0.05). Analysis by intention to treat showed that patients allocated to acarbose, compared with placebo, had 0.2% significantly lower median HbA1c at 3 years (P < 0.001). In patients remaining on their allocated therapy, the HbA1c difference at 3 years (309 acarbose, 470 placebo) was 0.5% lower median HbA1c (8.1 vs. 8.6%, P < 0.0001). Acarbose appeared to be equally efficacious when given in addition to diet alone; in addition to monotherapy with a sulfonylurea, metformin, or insulin; or in combination with more complex treatment regimens. No significant differences were seen in FPG, body weight, incidence of hypoglycemia, or frequency of major clinical events. CONCLUSIONS: Acarbose significantly improved glycemic control over 3 years in patients with established type 2 diabetes, irrespective of concomitant therapy for diabetes. Careful titration of acarbose is needed in view of the increased noncompliance rate seen secondary to the known side effects.  (+info)

Changes of fermentation pathways of fecal microbial communities associated with a drug treatment that increases dietary starch in the human colon. (6/145)

Acarbose inhibits starch digestion in the human small intestine. This increases the amount of starch available for microbial fermentation to acetate, propionate, and butyrate in the colon. Relatively large amounts of butyrate are produced from starch by colonic microbes. Colonic epithelial cells use butyrate as an energy source, and butyrate causes the differentiation of colon cancer cells. In this study we investigated whether colonic fermentation pathways changed during treatment with acarbose. We examined fermentations by fecal suspensions obtained from subjects who participated in an acarbose-placebo crossover trial. After incubation with [1-13C]glucose and 12CO2 or with unlabeled glucose and 13CO2, the distribution of 13C in product C atoms was determined by nuclear magnetic resonance spectrometry and gas chromatography-mass spectrometry. Regardless of the treatment, acetate, propionate, and butyrate were produced from pyruvate formed by the Embden-Meyerhof-Parnas pathway. Considerable amounts of acetate were also formed by the reduction of CO2. Butyrate formation from glucose increased and propionate formation decreased with acarbose treatment. Concomitantly, the amounts of CO2 reduced to acetate were 30% of the total acetate in untreated subjects and 17% of the total acetate in the treated subjects. The acetate, propionate, and butyrate concentrations were 57, 20, and 23% of the total final concentrations, respectively, for the untreated subjects and 57, 13, and 30% of the total final concentrations, respectively, for the treated subjects.  (+info)

Structure-function relationships in glucoamylases encoded by variant Saccharomycopsis fibuligera genes. (7/145)

The mutation Gly467-->Ser in Glu glucoamylase was designed to investigate differences between two highly homologous wild-type Saccharomycopsis fibuligera Gla and Glu glucoamylases. Gly467, localized in the conserved active site region, S5, is replaced by Ser in the Gla glucoamylase. These amino acid residues are the only two known to occupy this position in the elucidated glucoamylase sequences. The data from the kinetic analysis revealed that replacement of Gly467 with Ser in Glu glucoamylase decreased the kcat towards all substrates tested to values comparable with those of the Gla enzyme. Moreover, the mutant glucoamylase appeared to be less stable compared to the wild-type Glu glucoamylase with respect to thermal unfolding. Microcalorimetric titration studies of the interaction with the inhibitor acarbose indicated differences in the binding between Gla and Glu enzymes. The Gla glucoamylase, although less active, binds acarbose stronger (Ka congruent with 10(13).M(-1)) than the Glu enzyme (Ka congruent with 10(12).M(-1)). In all enzymes studied, the binding of acarbose was clearly driven by enthalpy, with a slightly favorable entropic contribution. The binding of another glucoamylase inhibitor, 1-deoxynojirimycin, was about 8-9 orders of magnitude weaker (Ka congruent with 10(4).M(-1)) than that of acarbose. From comparison of kinetic parameters for the nonglycosylated and glycosylated enzymes it can be deduced that the glycosylation does not play a critical role in enzymatic activity. However, results from differential scanning calorimetry demonstrate an important role of the carbohydrate moiety in the thermal stability of glucoamylase.  (+info)

Mechanism of porcine pancreatic alpha-amylase inhibition of amylose and maltopentaose hydrolysis by kidney bean (Phaseolus vulgaris) inhibitor and comparison with that by acarbose. (8/145)

The effects of Phaseolus vulgaris inhibitor (alpha-AI) on the amylose and maltopentaose hydrolysis catalysed by porcine pancreatic alpha-amylase (PPA) were investigated. Based on a statistical analysis of the kinetic data and using the general velocity equation, which is valid at equilibrium for all types of inhibition in a single-substrate reaction, it was concluded that the inhibitory mode is of the mixed noncompetitive type involving two molecules of inhibitor. In line with this conclusion, the Lineweaver-Burk primary plots intersect in the second quadrant and the secondary plots of the slopes and the intercepts versus the inhibitor concentrations are parabolic curves, whether the substrate used was amylose or maltopentaose. A specific inhibition model of the mixed noncompetitive type applies here. This model differs from those previously proposed for acarbose [Al Kazaz, M., Desseaux, V., Marchis-Mouren, G., Payan, F., Forest, E. & Santimone, M. (1996) Eur. J. Biochem. 241, 787-796 and Al Kazaz, M., Desseaux, V., Marchis-Mouren, G., Prodanov, E. & Santimone, M. (1998) Eur. J. Biochem. 252, 100-107]. In particular, with alpha-AI, the inhibition takes place only when PPA and alpha-AI are preincubated together before the substrate is added. This shows that the inhibitory PPA-alphaAI complex is formed during the preincubation period. Secondly, other inhibitory complexes are formed, in which two molecules of inhibitor are bound to either the free enzyme or the enzyme-substrate complex. The catalytic efficiency was determined both with and without inhibitor. Using the same molar concentration of inhibitor, alpha-AI was found to be a much stronger inhibitor than acarbose. However, when the inhibitor amount is expressed on a weight basis (mg x L-1), the opposite conclusion is drawn. In addition, limited proteolysis was performed on PPA alone and on the alpha-AI-PPA complex. The results show that, in the complex, PPA is more sensitive to subtilisin attack, and shorter fragments are obtained. These data reflect the conformational changes undergone by PPA as the result of the protein inhibitor binding, which differ from those previously observed with acarbose.  (+info)

TY - JOUR. T1 - Effects of the α-glucosidase inhibitor acarbose on postprandial serum glucose and insulin concentrations in healthy dogs. AU - Robertson, Jane. AU - Nelson, Richard W. AU - Kass, Philip H. AU - Neal, Larry. PY - 1999/5. Y1 - 1999/5. N2 - Objective - To determine effects of acarbose on baseline and postprandial serum glucose and insulin concentrations in healthy dogs, if effects of acarbose were dosage related, and if acarbose caused any short- term adverse effects. Animals - 5 healthy dogs fed a high-fiber diet. Procedure - A Latin-square design was used. During each 1-week treatment period, dogs were given a placebo or 25, 50, 100, or 200 mg of acarbose, PO, twice daily immediately prior to feeding. There was a 1-week interval between periods. At the end of each treatment period, serum glucose and insulin concentrations were measured prior to feeding and at 30- to 60-minute intervals for 6 hours after feeding. Results - Baseline serum glucose and insulin concentrations, insulin ...
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We assessed the cost-effectiveness of acarbose in the management of patients with impaired glucose tolerance (IGT) in Sweden, based on progression to type 2 diabetes (T2D) and cardiovascular (CV) events reported in the STOP-NIDDM trial population, including high-risk subgroups. The cost per patient free from T2D was SEK28 000 or SEK1260 per diabetes free month prior to progression to T2D. The cost per patient free from CV events was SEK101 000 or SEK5000 per CV event free month. For the high CV risk subgroups, acarbose treatment dominated placebo (i.e. acarbose was more effective, less costly).. Acarbose significantly reduces the incidence of diabetes and CV events in IGT patients. We predict this may translate into healthcare cost savings that partially or, in patients at high CV risk, fully offset the cost of acarbose. We conclude that acarbose is likely to be cost-effective in the management of impaired glucose tolerance.. ...
TY - JOUR. T1 - Effect of the disaccharidase inhibitor acarbose on meal glucose tolerance and timing of insulin administration in insulin-dependent diabetes. AU - Dimitriadis, G.. AU - Tessari, P.. AU - Rizza, R.. PY - 1982/1/1. Y1 - 1982/1/1. UR - http://www.scopus.com/inward/record.url?scp=0020416793&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0020416793&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0020416793. VL - 30. SP - 741A. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 4. ER - ...
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Optimal glycemic control in type 2 diabetes may require multiple forms of therapy, and an increasing number of hypoglycemic agents are now available. The study by Holman and colleagues describes the glucose-lowering properties of acarbose, an α-glucosidase inhibitor that is used as an adjunct to preexisting therapy. This study confirms earlier reports of the efficacy of acarbose (1). Based on its mechanism of action, which is the delay of carbohydrate absorption, acarbose should predominantly affect postprandial hyperglycemia. This is supported by the current data showing that acarbose had no effect on FPG level but was associated with lowered HbA1c levels at 3 years. Although increased gut carbohydrate absorption has not traditionally been seen as a contributor to postprandial hyperglycemia, recent data suggest that splanchnic glucose uptake may be altered (2). Delayed entry of glucose from the gut by α-glucosidase inhibition may alleviate these altered splanchnic responses. The major problem ...
Acarbose is pseudo-oligosaccharide with a terminal C7-cyclitol patented in 1975 by Bayer. Acarbose is a component of the amylostatin complex produced by species of Actinoplanes and Streptomyces. Acarbose acts as a potent inhibitor of α-glucosidases and saccharases. Since 1990, acarbose has been used therapeutically for the treatment of type 2 diabetes ...
Acarbose acts as an inhibitor of alpha-glucosidases and is therefore clinically used. The biosynthesis gene cluster (acb) was identified and partly characterized. The proposed model describes a pathway in which acarbose might function as a carbophor. The molecule is secreted into the medium where, after hydrolysis of starch, it is charged with additional glucose moieties. Re-uptake by a binding-protein dependent ABC importer AcbHFG would then result in a net gain of carbon and energy. Besides extracting glucose from the extracellular pool acarbose also acts as an inhibitor of alpha-amylases secreted by competitors in the natural environment. Prompted by the structural similarity between acarbose and maltotetraose, the effects of acarbose on the metabolism of maltose and maltodextrins in whole cells of E. coli and on individual components of the maltose / maltodextrin system were studied. The results demonstrate that acarbose is efficiently transported but not metabolized by E. coli due to its ...
Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase (Bayer AG). It is cheap and popular in China, but not in the U.S. One physician explains the use in the U.S. is limited because it is not potent enough to justify the side effects of diarrhea and flatulence. However, a recent large study concludes acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes. A possible explanation for the differing opinions is an observation that acarbose is significantly more effective in patients eating a relatively high carbohydrate Eastern diet. It is a starch blocker, and inhibits alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. It is composed of an acarviosin moiety with a maltose at the reducing terminus. Acarbose ...
In general, though, Acarbose should be taken three times daily at the start (with the first bite) of each main meal. Acarbose should be started at a low dose, with gradual dose escalation as described below, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. Do not take more or less of Acarbose than directed by your doctor ...
Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. Acarbose is used to treat type 2 diabetes. Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Acarbose may also be used for purposes not listed in this medication guide.
Acarbose is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.. DOSAGE Take exactly as prescribed by your doctor.. STORAGE. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.. MORE INFO. Active Ingredient: Acarbose. PRECOSE is available as 25 mg, 50 mg and 100 mg pills for oral use. The inactive ingredients are starch, microcrystalline cellulose, magnesium stearate, and colloidal silicon dioxide.. SAFETY INFORMATION. Do not use this medication if you are allergic to acarbose, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You also should not use acarbose if you have ...
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This study is a prospective randomized clinical trial to compare the endocrine and metabolic effects of two anti diabetic drugs (metformin vs. acarbose)
Blocking the absorption of carbohydrates at the brush border of the small intestine with acarbose (an alpha-glucosidase inhibitor) seems a promising possibility as a potential therapeutic agent. Although designed as a second-line diabetes drug, this medication has very little risk of hypoglycemia in older adults. In fact the risk of hypoglycemia is extremely low even in patients concurrently taking concurrent hypoglycemia agents (including insulin), and there is almost no risk of hypoglycemia in subjects not on other diabetes medications. Acarbose suppresses postprandial glycemia by slowing small intestinal digestion and absorption of carbohydrate, and has been shown to slow gastric emptying Acarbose has yet to be examined in a prospective fashion in older adults, despite the prevalence of PPH in this patient population. Preliminary, pilot work done in our laboratory on older adults with PPH has demonstrated that the hypotensive response over 90 minutes to a standardized meal was significantly ...
Conclusions: Type 2 Diabetes forms a significant share of the Diabetic load in India where cereals in the form of carbohydrates form the staple diet of most Indians. Thus α glucosidase inhibitors like Miglitol and acarbose are sure to play an important role as an add on therapy when first line drugs like sulphonylurea and biguanides fail to control the hyperglycaemia and they have minimum adverse effects, with more or less similar efficacy with Miglitol being better than Acarbose... Key words: Type 2 Diabetes Mellitus, Hyperglycaemia, PPBS, HbA1c, Miglitol, Acarbose ...
Acarbose was statistically significantly different from placebo at all doses with respect to effect on one-hour postprandial plasma glucose.. **The 300 mg t.i.d. acarbose regimen was superior to lower doses, but there were no statistically significant differences from 50 to 200 mg t.i.d. Clinical Experience in Type 2 Diabetes Mellitus Patients on Monotherapy, or in Combination with Sulfonylureas, Metformin or Insulin: acarbose was studied as monotherapy and as combination therapy to sulfonylurea, metformin, or insulin treatment. The treatment effects on HbA1c levels and one-hour postprandial glucose levels are summarized for four placebo-controlled, double-blind, randomized studies conducted in the United States in Tables 2 and 3, respectively. The placebo-subtracted treatment differences, which are summarized below, were statistically significant for both variables in all of these studies.. Study 1 (n=109) involved patients on background treatment with diet only. The mean effect of the addition ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Acarbose Generic Name: acarbose (ah KAR bose) Brand Names: Precose, Glucoobay What is acarbose? Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. Acarbose is used to treat type 2 diabetes. Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Acarbose may also be used for other purposes.. Please consult your medicial doctor for more information.. ...
Acarbose is used to treat type 2 diabetes. Normally, your pancreas releases insulin into the blood stream after you eat. Insulin is used by all the cells in your body to help turn the food you eat into energy. This is done by using glucose (sugar) in the blood as quick energy. When you have type 2 diabetes, insulin is still produced by your pancreas, but the amount of insulin produced may not be enough or your body may not be using it properly and you may still need more. Because of this, the insulin is not able to lower your blood sugar properly and you will have too much sugar in your blood. Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. It may be used alone or in combination with another type of oral diabetes medicine called a sulfonylurea. ...
In book, A Quick Understanding on What Doctors Are Prescribing: Pharmacology for Everyday People & Finding Alternative Medications , it described that acarbose works by competiting against carbohydrates found in food supposedly binding to enzyme in order to be digested, but now the place of binding is blocked by acarbose. As a result, less carbohydrate will be broken down into glucose molecules and sugar level in the blood will not be dramatically increased ...
Acarbose definition, a drug, C 25 H 43 NO 18 , used in the treatment of non-insulin-dependent diabetes: lowers blood sugar by inhibiting the enzymes that aid in starch and disaccharide digestion. See more.
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Postprandial hypotension (PPH) is a common condition that occurs primarily in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the effectiveness of acarbose for PPH; it also investigated possible mechanisms behind PPH development. This single-blind, randomized controlled trial included 91 elderly patients with T2DM, aged between 60 and 80 years, who were inpatients at Beijing Hospital between March 2012 and November 2014. The patients were included into one of three groups: Group A, patients with T2DM without PPH; Group B, patients with T2DM with PPH receiving placebo; and Group C, patients with T2DM with PPH receiving acarbose. After an overnight fast, patients received a single dose of acarbose (100 mg) or placebo and then consumed a standardized 450 kcal meal. Blood pressure, glucose levels, heart rate (HR), and catecholamine levels were evaluated. Acarbose ameliorated PPH as determined by significant improvements in the duration and maximal fall in blood ...
Metastatic renal cell carcinoma (RCC) exhibits high mortality rates and chemotherapeutic resistance. Immune-based therapies, including high-dose IL-2 and anti-PD1, are efficacious in ~20% of patients; however, both are associated with substantial toxicity. This highlights the need for additional research aimed at improving response rates while also limiting toxicity. Previous findings by other groups have demonstrated that nutrient deprivation prior to chemotherapy reduces treatment toxicity and may improve therapeutic efficacy in cancer patients. Recent murine research shows that diets containing calorie restriction mimetics (CRMs) can recapitulate these beneficial effects by enhancing anti-cancer immunity. Here, we examined the impact of the alpha-glucosidase inhibitor acarbose, a potential CRM, on renal tumor burden and immune profiles. BALB/c mice were fed an acarbose-containing diet or macronutrient-matched control diet for 4 weeks prior to challenge with syngeneic Renca renal carcinoma ...
Background: YKL-40 is involved in inflammation and endothelial dysfunction, and associated with diabetes and atherosclerosis disease. In the present s..
Mushrooms are a low calorie food with very little fat and are highly suitable for obese persons. The objective of the present investigation was to study the interaction of aqueous extract of P. pulmonarius (called PP-aqu) with acarbose on serum glucose levels, and on the oral glucose tolerance test (OGTT) in alloxan induced diabetic mice. PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination were administered orally in alloxan (70 mg/kg i.v.) induced diabetic mice. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimation at 7, 14, 21 and 28 days and recording of the body weights of the mice. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic mice half an hour after pre-treatment with PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination. Serum glucose levels were estimated 30 min prior to glucose ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 2gjp: Structure of Bacillus Halmapalus Alpha-Amylase, Crystallized With the Substrate Analogue Acarbose and Maltose
Acarbose improved long-term glycemic control in patients with non-insulin-dependent diabetes mellitus regardless of concomitant antidiabetic medication.
Acarbose 50 mg is a medicine for patient with diabetes mellitus. It controls blood sugar through reduce carbohydrate absorbtion in gut.
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This eMedTV Web page discusses some potential side effects of acarbose -- which can include gas, abdominal pain (or stomach pain), and diarrhea. This page also lists some serious side effects that you should report to your healthcare provider.
Acarbose Tablets slows the digestion of carbohydrates in the body, which helps control blood sugar levels.It is used together with diet and exercise to treat
Detailed Acarbose dosage information for adults. Includes dosages for Diabetes Type 2; plus renal, liver and dialysis adjustments.
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Q1. Potency of action of a) Miglitol is six times higher than that of acarbose b) Acarbose is more than that of miglitol c) Miglitol and acarbose is equa
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"acarbose - oral, Precose". MedicineNet. Retrieved 27 January 2014. "Peptimmune homepage". peptimmune.com. Archived from the ... A similar medication designed for patients with Type 2 diabetes is Acarbose; which partially blocks absorption of carbohydrates ...
Cereal and fungal products have been used for centuries for medicinal and cosmetic purposes; however, the specific role of β-glucan was not explored until the 20th century. β-glucans were first discovered in lichens, and shortly thereafter in barley. A particular interest in oat β-glucan arose after a cholesterol lowering effect from oat bran reported in 1981.[2] In 1997, the FDA approved of a claim that intake of at least 3.0 g of β-glucan from oats per day decreased absorption of dietary cholesterol and reduced the risk of coronary heart disease. The approved health claim was later amended to include these sources of β-glucan: rolled oats (oatmeal), oat bran, whole oat flour, oatrim (the soluble fraction of alpha-amylase hydrolyzed oat bran or whole oat flour), whole grain barley and barley beta-fiber. An example of an allowed label claim: Soluble fiber from foods such as oatmeal, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. A serving of ...
1 All cells are coated in either glycoproteins or glycolipids, both of which help determine cell types.[7] Lectins, or proteins that bind carbohydrates, can recognize specific oligosaccharides and provide useful information for cell recognition based on oligosaccharide binding.[citation needed] An important example of oligosaccharide cell recognition is the role of glycolipids in determining blood types. The various blood types are distinguished by the glycan modification present on the surface of blood cells.[15] These can be visualized using mass spectrometry. The oligosaccharides found on the A, B, and H antigen occur on the non-reducing ends of the oligosaccharide. The H antigen (which indicates an O blood type) serves as a precursor for the A and B antigen.[7] Therefore, a person with A blood type will have the A antigen and H antigen present on the glycolipids of the red blood cell plasma membrane. A person with B blood type will have the B and H antigen present. A person with AB blood ...
A disaccharide (also called a double sugar or bivose[1]) is the sugar formed when two monosaccharides (simple sugars) are joined by glycosidic linkage. Like monosaccharides, disaccharides are soluble in water. Three common examples are sucrose, lactose,[2] and maltose. Disaccharides are one of the four chemical groupings of carbohydrates (monosaccharides, disaccharides, oligosaccharides, and polysaccharides). The most common types of disaccharides-sucrose, lactose, and maltose-have 12 carbon atoms, with the general formula C12H22O11. The differences in these disaccharides are due to atomic arrangements within the molecule.[3] The joining of simple sugars into a double sugar happens by a condensation reaction, which involves the elimination of a water molecule from the functional groups only. Breaking apart a double sugar into its two simple sugars is accomplished by hydrolysis with the help of a type of enzyme called a disaccharidase. As building the larger sugar ejects a water molecule, ...
Garot (1850) "De la matière colorante rouge des rhubarbes exotiques et indigènes et de son application (comme matière colorante) aux arts et à la pharmacie" (On the red coloring material of exotic and indigenous rhubarb and on its application (as a coloring material) in the arts and in pharmacy), Journal de Pharmacie et de Chimie, 3rd series, 17 : 5-19. Erythrose is named on p. 10: "Celui que je propose, sans y attacher toutefois la moindre importance, est celui d'érythrose, du verbe grec 'ερυθραινω, rougir (1)." (The one [i.e., name] that I propose, without attaching any importance to it, is that of erythrose, from the Greek verb ερυθραινω, to redden (1).) ...
Many molecules that are considered to be "dietary fiber" are so because humans lack the necessary enzymes to split the glycosidic bond and they reach the large intestine. Many foods contain varying types of dietary fibers, all of which contribute to health in different ways. Dietary fibers make three primary contributions: bulking, viscosity and fermentation.[49] Different fibers have different effects, suggesting that a variety of dietary fibers contribute to overall health. Some fibers contribute through one primary mechanism. For instance, cellulose and wheat bran provide excellent bulking effects, but are minimally fermented. Alternatively, many dietary fibers can contribute to health through more than one of these mechanisms. For instance, psyllium provides bulking as well as viscosity. Bulking fibers can be soluble (i.e., psyllium) or insoluble (i.e., cellulose and hemicellulose). They absorb water and can significantly increase stool weight and regularity. Most bulking fibers are not ...
HSGAG and CSGAG modified proteoglycans first begin with a consensus Ser-Gly/Ala-X-Gly motif in the core protein. Construction of a tetrasaccharide linker that consists of -GlcAβ1-3Galβ1-3Galβ1-4Xylβ1-O-(Ser)-, where xylosyltransferase, β4-galactosyl transferase (GalTI),β3-galactosyl transferase (GalT-II), and β3-GlcA transferase (GlcAT-I) transfer the four monosaccharides, begins synthesis of the GAG modified protein. The first modification of the tetrasaccharide linker determines whether the HSGAGs or CSGAGs will be added. Addition of a GlcNAc promotes the addition of HSGAGs while addition of GalNAc to the tetrasaccharide linker promotes CSGAG development.[5] GlcNAcT-I transfers GlcNAc to the tetrasaccahride linker, which is distinct from glycosyltransferase GlcNAcT-II, the enzyme that is utilized to build HSGAGs. EXTL2 and EXTL3, two genes in the EXT tumor suppressor family, have been shown to have GlcNAcT-I activity. Conversely, GalNAc is transferred to the linker by the enzyme GalNAcT ...
... /ˌæmɪloʊˈpɛktɪn/ is a water-soluble[1][2] polysaccharide and highly branched polymer of α-glucose units found in plants. It is one of the two components of starch, the other being amylose. Amylopectin bears a straight/linear chain along with a number of side chains which may be branched further. Glucose units are linked in a linear way with α(1→4) Glycosidic bonds. Branching usually occurs at intervals of 25 residues. At the places of origin of a side chain, the branching that takes place bears an α(1→6) Glycosidic bond , resulting in a soluble molecule that can be quickly degraded as it has many end points onto which enzymes can attach. Wolform and Thompson (1956) have also reported α(1→3)linkages in case of Amylopectin. Amylopectin contains a larger number of Glucose units (2000 to 200,000) as compared to Amylose containing 200 to 1000 α-Glucose units. In contrast, amylose contains very few α(1→6) bonds, or even none at all. This causes amylose to be hydrolyzed ...
For the 24 hours after self-tanner (containing high DHA levels, ~5%) is applied, the skin is especially susceptible to free-radical damage from sunlight, according to a 2007 study led by Katinka Jung of the Gematria Test Lab in Berlin.[17] Forty minutes after the researchers treated skin samples with high levels of DHA they found that more than 180 percent additional free radicals formed during sun exposure compared with untreated skin. Another self-tanner ingredient, erythrulose, produced a similar response at high levels. For a day after self-tanner application, excessive sun exposure should be avoided and sunscreen should be worn outdoors, they say; an antioxidant cream could also minimize free radical production. Although some self-tanners contain sunscreen, its effect will not last long after application, and a fake tan itself will not protect the skin from UV exposure.[citation needed] The study by Jung et al. further confirms earlier results demonstrating that dihydroxyacetone in ...
The furanose ring is a cyclic hemiacetal of an aldopentose or a cyclic hemiketal of a ketohexose. A furanose ring structure consists of four carbon and one oxygen atom with the anomeric carbon to the right of the oxygen. The highest numbered chiral carbon (typically to the left of the oxygen in a Haworth projection) determines whether or not the structure has a ...
... was a luxury in Europe until the early 19th century, when it became more widely available, due to the rise of beet sugar in Prussia, and later in France under Napoleon.[31] Beet sugar was a German invention, since, in 1747, Andreas Sigismund Marggraf announced the discovery of sugar in beets and devised a method using alcohol to extract it.[32] Marggraf's student, Franz Karl Achard, devised an economical industrial method to extract the sugar in its pure form in the late 18th century.[33][34] Achard first produced beet sugar in 1783 in Kaulsdorf, and in 1801, the world's first beet sugar production facility was established in Cunern, Silesia (then part of Prussia).[35] The works of Marggraf and Achard were the starting point for the sugar industry in Europe,[36] and for the modern sugar industry in general, since sugar was no longer a luxury product and a product almost only produced in warmer climates.[37] Sugar became highly popular and by the 19th century, sugar came to be considered[by ...
Acarbose. *Fructooligosaccharide (FOS). *Galactooligosaccharide (GOS). *Isomaltooligosaccharide (IMO). *Maltodextrin. *Mannan- ...
Two monosaccharides with equivalent molecular graphs (same chain length and same carbonyl position) may still be distinct stereoisomers, whose molecules differ in the three-dimensional arrangement of the bonds of certain atoms. This happens only if the molecule contains a stereogenic center, specifically a carbon atom that is chiral (connected to four distinct molecular sub-structures). Those four bonds can have any of two configurations in space distinguished by their handedness. In a simple open-chain monosaccharide, every carbon is chiral except the first and the last atoms of the chain, and (in ketoses) the carbon with the keto group. For example, the triketose H(CHOH)(C=O)(CHOH)H (glycerone, dihydroxyacetone) has no stereogenic center, and therefore exists as a single stereoisomer. The other triose, the aldose H(C=O)(CHOH)2H (glyceraldehyde), has one chiral carbon - the central one, number 2 - which is bonded to groups −H, −OH, −C(OH)H2, and −(C=O)H. Therefore, it exists as two ...
... is an aldohexose sugar. It is a monosaccharide that is very rare in nature, but has been found in archaea, bacteria and eukaryotes.[2] It also exists as a syrup with a sweet taste. It is soluble in water and slightly soluble in methanol. Neither the ...
Miglitol is fairly well absorbed by the body, as opposed to acarbose. Moreover, acarbose inhibits pancreatic alpha-amylase in ... there are subtle differences between acarbose and miglitol. Acarbose is an oligosaccharide, whereas miglitol resembles a ... Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha- ... Examples of alpha-glucosidase inhibitors include: Acarbose- Precose or Glucobay Miglitol - Glyset Voglibose Even though the ...
Acarbose is an enzyme inhibitor that is used as a drug against type 2 diabetes. Miglustat is an iminosugar in which the ring ... Tamiflu is an enzyme inhibitor that blocks the action of influenza virus neuraminidases (sialidases). Acarbose is a ...
CS1 maint: discouraged parameter (link) Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes ... a precursor to the antidiabetic drug acarbose and to the antibiotic validamycin), teicoplanin, and ramoplanin. Euzéby, J. P. " ...
... is part of the potent α-amylase inhibitor acarbose and its derivatives. The nitrogen atom binds to α-amylase more ...
Lettieri JT, Dain B (1998). "Effects of beano on the tolerability and pharmacodynamics of acarbose". Clin Ther. 20 (3): 497-504 ... Another study indicates it may interfere with the diabetic medication acarbose.[4] ...
Within the -1 subsite, isomaltose's non-reducing glucose ring was aligned to that of acarbose. Not only has the structure of ...
One situation where starch may be less effective than glucose or sucrose is when a person is taking acarbose. Since acarbose ... Starch is quickly digested to glucose (unless the person is taking acarbose), but adding fat or protein retards digestion. ...
There are three drugs which belong to this class, acarbose, miglitol and voglibose, of which voglibose is the newest. Chen X, ...
Tuğrul S, Kutlu T, Pekin O, Bağlam E, Kiyak H, Oral O (October 2008). "Clinical, endocrine, and metabolic effects of acarbose, ...
"Complex structures of Thermoactinomyces vulgaris R-47 alpha-amylase 2 with acarbose and cyclodextrins demonstrate the multiple ...
... prepared from the leaf of Ludwigia adscendens exhibits alpha-glucosidase inhibitory activity more potent than that of acarbose ...
Inhibitors that are in clinical use include the anti-diabetic drugs acarbose and miglitol, and the antiviral drugs oseltamivir ...
Typical reductions in glycated hemoglobin (A1C) values are 0.5-1.0%. miglitol acarbose voglibose These medications are rarely ... Acarbose Meglitinides - nateglinide Combination of sulfonylureas plus metformin - known by generic names of the two drugs No ...
... is a species of bacteria and a source of the drug acarbose, an alpha-glucosidase inhibitor used in the ...
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Acarbose: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking acarbose,. *tell your doctor and pharmacist if you are allergic to acarbose or any other drugs. ... Continue to take acarbose even if you feel well. Do not stop taking acarbose without talking to your doctor. ... Acarbose comes as a tablet to take by mouth. It is usually taken three times a day. It is very important to take each dose with ...
Glucobay tablets contain the active ingredient acarbose, which is a medicine used to help control blood sugar levels in people ... Glucobay (acarbose). Glucobay tablets contain the active ingredient acarbose, which is a medicine used to help control blood ... Acarbose may reduce the absorption of digoxin from the gut, which may reduce its blood level and make it less effective. If you ... Acarbose is taken with meals to delay the breakdown of sugars and starches in the gut and slow down their absorption into the ...
... Glucobay tablets contain the active ingredient acarbose, which is a medicine used to help control blood ... Acarbose may reduce the absorption of digoxin from the gut, which may reduce its blood level and make it less effective. If you ... Acarbose is taken with meals to delay the breakdown of sugars and starches in the gut and slow down their absorption into the ... Acarbose can be used on its own to treat people with type 2 diabetes whose blood sugar has not been controlled sufficiently by ...
Acarbose definition, a drug, C 25 H 43 NO 18 , used in the treatment of non-insulin-dependent diabetes: lowers blood sugar by ...
"Acarbose". MedlinePlus Drug Information. "Acarbose: hepatitis: France, Spain". WHO Pharmaceuticals Newsletter. 1999. Harrison ... Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a ... Since acarbose prevents the digestion of complex carbohydrates, the drug should be taken at the start of main meals (taken with ... "Acarbose". Drug Information Portal. U.S. National Library of Medicine. "Probing the Pancreas" - by Craig D. Reid, Ph.D. (US FDA ...
The fraction of acarbose that is absorbed as intact drug is almost completely excreted by the kidneys. When acarbose was given ... Acarbose Tablets are an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus. Acarbose is an ... Acarbose Tablets are contraindicated in patients with known hypersensitivity to the drug. Acarbose Tablets are contraindicated ... In contrast to sulfonylureas, Acarbose Tablets do not enhance insulin secretion. The antihyperglycemic action of acarbose ...
Acarbose, miglitol, and pramlintide help prevent glucose absorption to treat diabetes. Learn how they work, how you take them, ... Acarbose and miglitol are available as generic and brand-name drugs. Precose is the brand-name drug for acarbose. Glyset is the ... Side effects of acarbose, miglitol, and pramlintide. Acarbose, miglitol, and pramlintide can cause side effects for some people ... Both acarbose and miglitol come in a tablet you take by mouth. You take them with the first bite of each meal. If you dont ...
... acarbose) is a prescription drug used to treat type 2 diabetes. Side effects may include diarrhea and flatulence (gas). Serious ... Acarbose alone does not produce hypoglycemia.. *Charcoal may absorb acarbose and digestive enzyme preparations such as amylase ... When was acarbose approved by the FDA?. *The FDA approved acarbose in September 1995. ... Since adding insulin or a sulfonylurea to acarbose therapy may lower blood glucose more than acarbose alone, the risk for ...
Detailed Acarbose dosage information for adults. Includes dosages for Diabetes Type 2; plus renal, liver and dialysis ...
Glucobay; MAR-Acarbose. What is this drug used for?. *It is used to lower blood sugar in patients with high blood sugar ( ... Acarbose - Last updated on August 31, 2021. All rights owned and reserved by Memorial Sloan Kettering Cancer Center. ...
Acarbose) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications ... The fraction of acarbose that is absorbed as intact drug is almost completely excreted by the kidneys. When acarbose was given ... acarbose) Tablets. DESCRIPTION. PRECOSE® (acarbose tablets) is an oral alpha-glucosidase inhibitor for use in the management of ... Acarbose did not induce any DNA damage in vitro in the CHO chromosomal aberration assay, bacterial mutagenesis (Ames) assay, or ...
A Moderate Drug Interaction exists between acarbose and dexbrompheniramine / pseudoephedrine. View detailed information ... Drug Interactions between acarbose and dexbrompheniramine / pseudoephedrine. This report displays the potential drug ... Pseudoephedrine may interfere with blood glucose control and reduce the effectiveness of acarbose and other diabetic ...
... is sometimes used in combination with insulin or other diabetes medications you take by mouth. Acarbose may also be ... Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. Acarbose is used to treat ... What is acarbose?. Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. ... Acarbose is used to treat type 2 diabetes. Acarbose is sometimes used in combination with insulin or other diabetes medications ...
Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. It may be used alone or in combination with ... Acarbose is used to treat type 2 diabetes. Normally, your pancreas releases insulin into the blood stream after you eat. ...
Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Acarbose may also be ... Acarbose is used together with diet and exercise to treat type 2 diabetes. ... Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. ... What is acarbose?. Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. ...
Hints: Click on a [map] link to show a map of that region. Click on a [studies] link to search within your current results for studies in that region. Use the back button to return to this list and try another region. Studies with no locations are not included in the counts or on the map. Studies with multiple locations are included in each region containing locations ...
... is a brand of medicine containing the active ingredient Acarbose. Find out about side effects, who can ... Before you take ACARBOSE MYLAN. When you must not take it. Do not take ACARBOSE MYLAN if you have an allergy to:. *acarbose, ... What ACARBOSE MYLAN is used for. ACARBOSE MYLAN tablets contain the active drug acarbose. They are used for the treatment of ... After taking ACARBOSE MYLAN. When treatment with ACARBOSE MYLAN is to be stopped, your prescribing doctor may need to alter the ...
MODIFIED ACARBOSE HEXASACCHARIDE. C37 H63 N O26. YXELUDMUQSCWQW-HCVSURSQSA-N. Ligand Interaction. ... Structure of the Aspergillus oryzae alpha-amylase complexed with the inhibitor acarbose at 2.0 A resolution.. Brzozowski, A.M. ... The three-dimensional structure of the Aspergillus oryzae alpha-amylase (TAKA-amylase), in complex with the inhibitor acarbose ... The three-dimensional structure of the Aspergillus oryzae alpha-amylase (TAKA-amylase), in complex with the inhibitor acarbose ...
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Acarbose hat als Inhibitor von Hydrolasen alpha-1,4-glykosidischer Bindungen medizinische Bedeutung. Das Acarbose-Biosynthese- ... Prompted by the structural similarity between acarbose and maltotetraose, the effects of acarbose on the metabolism of maltose ... Acarbose acts as an inhibitor of alpha-glucosidases and is therefore clinically used. The biosynthesis gene cluster (acb) was ... The proposed model describes a pathway in which acarbose might function as a carbophor. The molecule is secreted into the ...
Drug Name: Acarbose. Ingredient(s): ACARBOSE[ACARBOSE]. Imprint: E71. Dosage: 25 mg. Color(s): White. Shape: Round. Size (mm): ... Drug Name: Acarbose. Ingredient(s): ACARBOSE[ACARBOSE]. Imprint: E72. Dosage: 50 mg. Color(s): White. Shape: Round. Size (mm): ... Drug Name: Acarbose. Ingredient(s): ACARBOSE[ACARBOSE]. Imprint: AR. Dosage: 25 mg. Color(s): White. Shape: Round. Size (mm): 6 ... Drug Name: Acarbose. Ingredient(s): ACARBOSE[ACARBOSE]. Imprint: AR;50. Dosage: 50 mg. Color(s): White. Shape: Round. Size (mm) ...
Effectiveness of acarbose in the control of glucose tolerance worsening in pregnancy].. [Article in Spanish] ... Six pregnant women who had moderate elevated level of blood glucose at fasting and postprandial were treated with acarbose, ... Acarbose was associated with intestinal discomfort which persisted during the whole pregnancy. ...
Drug: Acarbose Acarbose 50 mg given during Meal Test and Acarbose 25 mg taken with first bite of the next 3 meals. ... During the second Meal Test subject will receive Acarbose 50mg and will take Acarbose 25mg with first bite of each of the next ... Acarbose and Older Adults With Postprandial Hypotension (PPH). The safety and scientific validity of this study is the ... Starting the day following each meal test, each subject with PPH will take either acarbose 25 mg po tid (prior to each meal) or ...
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial.. Chiasson JL1, Josse RG, Gomis R, ... Acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of type 2 ... We aimed to assess the effect of acarbose in preventing or delaying conversion of impaired glucose tolerance to type 2 diabetes ... Acarbose delays onset of type 2 diabetes mellitus. [J Fam Pract. 2002] ...
Effect of acarbose on insulin sensitivity in elderly patients with diabetes.. G S Meneilly, E A Ryan, J Radziuk, D C Lau, J F ... Effect of acarbose on insulin sensitivity in elderly patients with diabetes.. G S Meneilly, E A Ryan, J Radziuk, D C Lau, J F ... Effect of acarbose on insulin sensitivity in elderly patients with diabetes. Message Subject (Your Name) has forwarded a page ... acarbose group, P , 0.001) between groups. There was a significant difference in the change in HbA(1c) values in response to ...
Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes. Diabetes Metab Res Rev. 2013 Oct; ... "Acarbose" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject Headings ... This graph shows the total number of publications written about "Acarbose" by people in Harvard Catalyst Profiles by year, and ... Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease. J Hepatol. 2009 Sep; 51(3):548- ...
Acarbose. The Anatomical Therapeutic Chemical (ATC) classification system from Drugs-about.com includes all drugs classified in ... A10BF01 - Acarbose *Acarbose ATC Classification , Pharmaceutical Drugs , Pharma Doctor , Sitemap , About Copyright © 2005-2018 ...
Acarbose tablets. What is this medicine?. ACARBOSE (AY car bose) helps to treat type 2 diabetes. It helps to control blood ... an unusual or allergic reaction to acarbose, other medicines, foods, dyes, or preservatives ...
Acarbose, alpha-glucosidase inhibitor (CAS 56180-94-0), with ,99% purity. Water soluble compound. Join researchers using our ... Acarbose, an alpha-glucosidase inhibitor, improves insulin resistance in fructose-fed rats.. Drugs Exp Clin Res 31:155-9 (2005 ... Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor acarbose (BAY g 5421).. Digestion 23: ...
  • Precose is the brand-name drug for acarbose. (healthline.com)
  • Precose is the brand name available for acarbose. (medicinenet.com)
  • Precose medication is available as acarbose 25 mg, acarbose 50 mg, and acarbose 100 mg tablets. (canadapharmacy.com)
  • Acarbose (Glucobay ® in Europe or Precose ® in the USA), is a recently approved drug for use in (1) insulin-dependant diabetes mellitus (Type I), (2) adult-onset diabetes mellitus (AODM, or Type II), and (3) those who suffer from "impaired glucose tolerance. (antiaging-systems.com)
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  • Precose is an oral medication, and the active ingredient is Acarbose, which aims to balance the blood sugar levels after each meal by slowing the breaking of carbohydrates. (rxmedscanada.com)
  • Even though it is generally safe to take Precose if you use other drugs for diabetes control, such as insulin or metformin (which work differently than Acarbose), it is highly recommended to inform your doctor about all the medications you are taking before starting the treatment with Precose. (rxmedscanada.com)
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  • Acarbose, which is the generic for Precose, is manufactured by Bayer Pharmaceuticals for North America. (diabetor.com)
  • Precose (acarbose) is an alpha glucosidase inhibitor. (diabetor.com)
  • Acarbose ( Precose ® ) is a prescription medication that is used to treat type 2 diabetes (also known as non- insulin -dependent diabetes or adult-onset diabetes). (emedtv.com)
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  • Acarbose or (Precose in US, Glucobay in Europe, Prandase in Canada) is prescribed for treating Type 2 diabetes. (arthurwiz.com)
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  • Acarbose works by slowing the action of certain chemicals that break down food to release glucose (sugar) into your blood. (medlineplus.gov)
  • Acarbose is an oligosaccharide which is obtained from fermentation processes of a microorganism, Actinoplanes utahensis , and is chemically known as O-4,6-dideoxy-4-[[(1 S ,4 R ,5 S ,6 S )-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)- O -α-D-glucopyranosyl-(1→4)-D-glucose. (nih.gov)
  • Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. (nih.gov)
  • As a consequence of plasma glucose reduction, Acarbose Tablets reduce levels of glycosylated hemoglobin in patients with type 2 diabetes mellitus. (nih.gov)
  • One metabolite (formed by cleavage of a glucose molecule from acarbose) also has alpha-glucosidase inhibitory activity. (nih.gov)
  • The combination of acarbose with metformin results in greater reductions of HbA1c, fasting blood glucose and post-prandial glucose than either agent alone. (wikipedia.org)
  • However the maximum dose per day is 600 mg.[citation needed] Since acarbose prevents the degradation of complex carbohydrates into glucose, some carbohydrate will remain in the intestine and be delivered to the colon. (wikipedia.org)
  • If a patient using acarbose suffers from a bout of hypoglycemia, the patient must eat something containing monosaccharides, such as glucose tablets or gel (GlucoBurst, Insta-Glucose, Glutose, Level One) and a doctor should be called. (wikipedia.org)
  • Acarbose is a prescription oral drug that is used to control blood glucose ( sugar ) levels in people type 2 diabetes in conjunction with diet , exercise , and other diabetes drugs , for example, metformin ( Glucophage ) or insulin . (medicinenet.com)
  • Since adding insulin or a sulfonylurea to acarbose therapy may lower blood glucose more than acarbose alone, the risk for developing hypoglycemia is greater when these drugs are combined. (medicinenet.com)
  • If mild to moderate hypoglycemia occurs while taking acarbose in combination with another anti-diabetic drug, the treatment for hypoglycemia is with with oral glucose (dextrose) instead of sucrose (table sugar) because acarbose blocks the digestion of sucrose to glucose, and hypoglycemia will not be corrected rapidly with sucrose. (medicinenet.com)
  • Pseudoephedrine may interfere with blood glucose control and reduce the effectiveness of acarbose and other diabetic medications. (drugs.com)
  • Besides extracting glucose from the extracellular pool acarbose also acts as an inhibitor of alpha-amylases secreted by competitors in the natural environment. (hu-berlin.de)
  • Maintenance dosage: Once a 25 mg t.i.d. dosage regimen is reached, dosage of acarbose should be adjusted at 4-8 week intervals based on one-hour postprandial glucose or glycosylated hemoglobin levels, and on tolerance. (wikidoc.org)
  • Because acarbose given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose, it may increase the potential for hypoglycemia . (wikidoc.org)
  • Oral glucose ( dextrose ), whose absorption is not inhibited by acarbose, should be used instead of sucrose (cane sugar) in the treatment of mild to moderate hypoglycemia . (wikidoc.org)
  • Sucrose, whose hydrolysis to glucose and fructose is inhibited by acarbose, is unsuitable for the rapid correction of hypoglycemia. (wikidoc.org)
  • Effectiveness of acarbose in the control of glucose tolerance worsening in pregnancy]. (nih.gov)
  • Six pregnant women who had moderate elevated level of blood glucose at fasting and postprandial were treated with acarbose, alpha-glucosidase inhibitor agent, given three times a day before meals. (nih.gov)
  • We aimed to assess the effect of acarbose in preventing or delaying conversion of impaired glucose tolerance to type 2 diabetes. (nih.gov)
  • In a multicentre, placebo-controlled randomised trial, we randomly allocated patients with impaired glucose tolerance to 100 mg acarbose or placebo three times daily. (nih.gov)
  • We randomly allocated 714 patients with impaired glucose tolerance to acarbose and 715 to placebo. (nih.gov)
  • Acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of type 2 diabetes in patients with impaired glucose tolerance. (nih.gov)
  • While you are taking Acarbose, you should check your blood and urine periodically for the presence of abnormal sugar (glucose) levels. (health-care-information.org)
  • Acarbose can help you remedy high glucose levels, to help the body absorb it and use effectively. (allhealthguides.com)
  • Accordingly, via above mechanism, Acarbose lowers the risk of kidney failure and heart disease, both of which are caused by high glucose levels. (allhealthguides.com)
  • Acarbose reduces food cravings by slowing the absorption of glucose and reducing sugar highs. (antiaging-systems.com)
  • Glucobay Acarbose is your essential treatment because it helps regulate glucose, your body's preferred source of energy. (antiaging-systems.com)
  • Acarbose is important if your body does not produce insulin, or your natural insulin does not unlock glucose properly. (antiaging-systems.com)
  • It works in the small intestine where Acarbose inhibits the actions of enzymes that breakdown complex carbohydrates into simpler sugars such as glucose. (antiaging-systems.com)
  • But by taking Glucobay Acarbose, we reduce our desire for glucose-rich foods. (antiaging-systems.com)
  • Glucose is also not affected by acarbose. (antiaging-systems.com)
  • Consequently, glucose and lactose are absorbed normally when acarbose is taken. (antiaging-systems.com)
  • 1993) speculated that acarbose might improve insulin sensitivity (as indicated by decreasing fasting blood glucose). (antiaging-systems.com)
  • Acarbose is an alfa-Glycosidase inhibitor acts by slowing the absorption of carbohydrates from the intestine, prevents Glucosidase activity in the brush-border of the intestinal mucosa, decreasing disaccharide digestion, reducing enteric monosaccharide absorption, so minimizing the postprandial rise of blood glucose concentration. (knowcancer.com)
  • Cost-effectiveness of acarbose for the management of impaired glucose tolerance in Sweden. (diva-portal.org)
  • We assessed the cost-effectiveness of acarbose in the management of patients with impaired glucose tolerance (IGT) in Sweden, based on progression to type 2 diabetes (T2D) and cardiovascular (CV) events reported in the STOP-NIDDM trial population, including high-risk subgroups. (diva-portal.org)
  • We conclude that acarbose is likely to be cost-effective in the management of impaired glucose tolerance. (diva-portal.org)
  • The study by Holman and colleagues describes the glucose-lowering properties of acarbose, an α-glucosidase inhibitor that is used as an adjunct to preexisting therapy. (acpjc.org)
  • Effect of Acarbose, Sitagliptin and combination therapy on blood glucose, insulin, and incretin hormone concentrations in experimentally induced postprandial hyperglycemia of healthy cats. (researchmap.jp)
  • Because acarbose slows down the absorption of sucrose (also known as table sugar, or the type of sugar that is in most food and drinks), glucose tablets (instead of food or drinks) should be used to help correct low blood sugar in people taking acarbose. (emedtv.com)
  • Accumulating evidence has shown that apart from its multiple effects on primarily postprandial glucose dysmetabolism, a key component of mechanisms linked to increased incidence of CV events, acarbose therapy also associates with a favorable impact on an array of surrogate markers of CV disease. (ox.ac.uk)
  • Large scale trials, like the ongoing Acarbose Cardiovascular Evaluation (ACE) trial, aim at conclusively establishing such a positive effect in patients with coronary heart disease and impaired glucose tolerance. (ox.ac.uk)
  • Current discouraging results from many trials of antidiabetic medications to significantly lower CV event rates in diabetic patients, should only draw further attention on alternative glucose lowering agents, among which acarbose is indeed promising. (ox.ac.uk)
  • Take acarbose exactly as directed. (medlineplus.gov)
  • Continue to take acarbose even if you feel well. (medlineplus.gov)
  • Take acarbose with the first bite of a main meal, unless your doctor tells you otherwise. (cardiosmart.org)
  • If you take acarbose with insulin or other diabetes medications, your blood sugar could get too low. (cardiosmart.org)
  • How should I take acarbose? (cardiosmart.org)
  • If it has been longer than 15 minutes since you started your meal, you may still take acarbose but it may be less effective than taking it with the first bite of the meal. (uwhealth.org)
  • During the second Meal Test subject will receive Acarbose 50mg and will take Acarbose 25mg with first bite of each of the next 3 meals. (clinicaltrials.gov)
  • How to take Acarbose? (health-care-information.org)
  • Do not take Acarbose if you suffer from intestinal, inflammatory or ulceration disorders. (antiaging-systems.com)
  • Do not take acarbose with medicines used to help digest food, such as amylase or pancreatin. (allinahealth.org)
  • Therefore, people with severe kidney problems (including kidney failure) should not take acarbose. (emedtv.com)
  • Glucobay tablets contain the active ingredient acarbose, which is a medicine used to help control blood sugar levels in people with type 2 (non-insulin dependent) diabetes. (netdoctor.co.uk)
  • Acarbose Tablets are an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus. (nih.gov)
  • Acarbose Tablets are available as 25 mg, 50 mg and 100 mg tablets for oral use. (nih.gov)
  • In contrast to sulfonylureas, Acarbose Tablets do not enhance insulin secretion. (nih.gov)
  • Because its mechanism of action is different, the effect of Acarbose Tablets to enhance glycemic control is additive to that of sulfonylureas, insulin or metformin when used in combination. (nih.gov)
  • In addition, Acarbose Tablets diminish the insulinotropic and weight-increasing effects of sulfonylureas. (nih.gov)
  • Please read this leaflet carefully before you start using Acarbose Mylan Tablets. (nps.org.au)
  • ACARBOSE MYLAN tablets contain the active drug acarbose. (nps.org.au)
  • If you suffer from pre-diabetic condition, where your blood sugar is higher than normal and you might be experiencing weight gain, Acarbose Glucobay tablets might be able to help. (allhealthguides.com)
  • Acarbose tablets should be taken before meal. (allhealthguides.com)
  • All participants will be asked to take their current dose of metformin tablets and either voglibose or acarbose tablets three times a day throughout the study. (clinicaltrials.gov)
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  • Effect of acarbose on insulin sensitivity in elderly patients with diabetes. (diabetesjournals.org)
  • OBJECTIVE: To study the effect of acarbose, an alpha-glucosidase inhibitor, on insulin release and insulin sensitivity in elderly patients with type 2 diabetes. (diabetesjournals.org)
  • Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes. (harvard.edu)
  • We examined the effect of acarbose ( n = 4), glibenclamide ( n = 6), and placebo ( n = 6) on insulin and leptin levels during 24-h periods before and after 16 weeks of therapy. (diabetesjournals.org)
  • What are the side effects of acarbose? (medicinenet.com)
  • Prompted by the structural similarity between acarbose and maltotetraose, the effects of acarbose on the metabolism of maltose and maltodextrins in whole cells of E. coli and on individual components of the maltose / maltodextrin system were studied. (hu-berlin.de)
  • Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers," Evidence-Based Complementary and Alternative Medicine , vol. 2014, Article ID 308126, 9 pages, 2014. (hindawi.com)
  • Click Side Effects of Acarbose to learn about the specific side effects of this drug, including serious side effects to look out for. (emedtv.com)
  • What is the treatment dosage for acarbose? (medicinenet.com)
  • There is no fixed dosage regimen for the management of diabetes mellitus with Acarbose or any other pharmacologic agent. (health-care-information.org)
  • Dosage of Acarbose must be individualized on the basis of both effectiveness and tolerance while not exceeding the maximum recommended dose of 100 mg t. i. d. (health-care-information.org)
  • Extensive evidence shows this weight loss can be achieved through regular Acarbose dosage. (antiaging-systems.com)
  • Acarbose provides the appropriate dosage and is tested and proven over two decades to ensure that diabetics weight loss can be maintained. (antiaging-systems.com)
  • Do not change the dosage or discontinue the use of acarbose without first talking to your doctor. (blogspot.com)
  • Moreover, the amount of complex carbohydrates in the meal will determine the effectiveness of acarbose in decreasing postprandial hyperglycemia. (wikipedia.org)
  • Because of its mechanism of action, acarbose when administered alone should not cause hypoglycemia in the fasted or postprandial state. (wikidoc.org)
  • Acarbose suppresses postprandial glycemia by slowing small intestinal digestion and absorption of carbohydrate, and has been shown to slow gastric emptying Acarbose has yet to be examined in a prospective fashion in older adults, despite the prevalence of PPH in this patient population. (clinicaltrials.gov)
  • Based on its mechanism of action, which is the delay of carbohydrate absorption, acarbose should predominantly affect postprandial hyperglycemia. (acpjc.org)
  • Branded as Glucobay Acarbose, it helps diabetes sufferers live more normal lives. (antiaging-systems.com)
  • Glucobay Acarbose taken daily helps you feel full for longer by providing a more stable supply of essential blood sugars. (antiaging-systems.com)
  • Glucobay Acarbose also assists diabetics with weight loss . (antiaging-systems.com)
  • Glucobay Acarbose will help if you have Type 1 diabetes which results from the body's inability to produce insulin. (antiaging-systems.com)
  • Glucobay Acarbose is equally essential if you suffer Type 2 diabetes due to insulin resistance. (antiaging-systems.com)
  • Glucobay Acarbose is ideal for Type 2 sufferers, by helping to reduce the risks of heart disease and strokes , kidney failure , limb amputation and the onset of blindness. (antiaging-systems.com)
  • Glucobay Acarbose can either be prescribed as a single therapy, or it can be used in conjunction with other treatments. (antiaging-systems.com)
  • For antiaging and appetite suppression, take one 50mg Glucobay Acarbose tablet one to three times daily. (antiaging-systems.com)
  • and the property is manifestly an glucobay acarbose 50 mg two out of five. (sayitwithwine.co.uk)
  • Alpha-glucosidase inhibitors such as Acarbose are used to help lower blood sugar levels that are not controlled by diet and exercise. (health-care-information.org)
  • Launched in 1990, Acarbose belongs to a class of drugs known as alpha-glucosidase inhibitors. (antiaging-systems.com)
  • Other benefits of alpha glucosidase inhibitors are their ability to prevent or attenuate diabetic nephropathic lesions (Bischoff, 1995), and one study even reported an improvement in cognitive function in both animals and elderly patients given acarbose! (antiaging-systems.com)
  • Thus α glucosidase inhibitors like Miglitol and acarbose are sure to play an important role as an add on therapy when first line drugs like sulphonylurea and biguanides fail to control the hyperglycaemia and they have minimum adverse effects, with more or less similar efficacy with Miglitol being better than Acarbose. (scopemed.org)
  • Acarbose, like other alpha-glucosidase inhibitors (AGIs), has been proven to be an effective antidiabetic treatment for decades, but the overall significant impact of this class of drugs on modulating CV risk has only recently been appreciated. (ox.ac.uk)
  • Acarbose works by slowing the breakdown and absorption of sugars and starches in the gut. (netdoctor.co.uk)
  • Acarbose is taken with meals to delay the breakdown of sugars and starches in the gut and slow down their absorption into the blood. (netdoctor.co.uk)
  • This is because acarbose will delay the absorption of sucrose. (netdoctor.co.uk)
  • The delayed absorption of acarbose-related radioactivity reflects the absorption of metabolites that may be formed by either intestinal bacteria or intestinal enzymatic hydrolysis. (nih.gov)
  • Acarbose may interfere with digoxin ( Lanoxin ) absorption thereby decreasing digoxin blood levels and its effect. (medicinenet.com)
  • Blocking the absorption of carbohydrates at the brush border of the small intestine with acarbose (an alpha-glucosidase inhibitor) seems a promising possibility as a potential therapeutic agent. (clinicaltrials.gov)
  • Acarbose delays carbohydrate digestion and absorption. (antiaging-systems.com)
  • Acarbose, an inhibitor of intestinal α-glucosidase, impairs carbohydrate digestion and delays, and partially prevents, absorption of carbohydrate. (acpjc.org)
  • Acarbose works in your intestines to slow the breakdown and absorption of carbohydrates from foods that you eat. (ndclist.com)
  • Acarbose alone does not produce hypoglycemia. (medicinenet.com)
  • When taking acarbose, dextrose will work better than cane sugar or table sugar in treating hypoglycemia. (uwhealth.org)
  • Hypoglycemia does not occur in patients receiving metformin alone under usual circumstances of use, and no increased incidence of hypoglycemia was observed in patients when acarbose was added to metformin therapy. (wikidoc.org)
  • Compared with sulfonylureas as the add-on therapy to metformin, the use of acarbose was associated with significantly lower risks of hospitalizations for major atherosclerotic events (hazard ratio and 95% confidence intervals: 0.69, 0.52-0.91), ischemic stroke (0.68, 0.49-0.94), and hypoglycemia (0.23, 0.08-0.71), after accounting for major confounding factors. (medpagetoday.com)
  • In T2D treatment, use of acarbose as the add-on remedy to metformin was associated with lower risks of major atherosclerotic events, ischemic stroke, and hypoglycemia, compared with sulfonylurea. (medpagetoday.com)
  • When used alone, acarbose does not cause low blood sugar (hypoglycemia). (emedtv.com)
  • If you are using acarbose with insulin or other diabetes medications, your blood sugar levels will be too low (hypoglycemia). (blogspot.com)
  • After-meal hypoglycemia is a potentially severe complication of the Roux-en-Y gastric bypass procedure. (pharmanerd.com)
  • If dietary modifications are not effective, taking acarbose before a meal can prevent carbohydrates from being broken down and thus also prevent the excess insulin and hypoglycemia. (pharmanerd.com)
  • Do not stop taking acarbose without talking to your doctor. (medlineplus.gov)
  • Your doctor may want you to stop taking acarbose for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency. (silverpharmacy.com)
  • Do not use this medication if you are allergic to acarbose, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). (cardiosmart.org)
  • Acarbose may also be used for purposes not listed in this medication guide. (cardiosmart.org)
  • Acarbose is an oral medication used to treat type 2 (noninsulin-dependent) diabetes. (health-care-information.org)
  • Acarbose improved long-term glycemic control in patients with non-insulin-dependent diabetes mellitus regardless of concomitant antidiabetic medication. (nih.gov)
  • Acarbose is considered pregnancy Category B medication. (emedtv.com)
  • Do not use this medication if you are allergic to acarbose, or if you have a condition diabetic ketoacidosis. (blogspot.com)
  • Acarbose is a medication for diabetes, taken to lower blood sugar. (pharmanerd.com)
  • The antihyperglycemic action of acarbose results from a competitive, reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. (nih.gov)
  • Acarbose is metabolized exclusively within the gastrointestinal tract, principally by intestinal bacteria, but also by digestive enzymes. (nih.gov)
  • Before taking acarbose, tell your doctor if you have liver disease, or any type of stomach or intestinal disorder. (cardiosmart.org)
  • Acarbose was associated with intestinal discomfort which persisted during the whole pregnancy. (nih.gov)
  • Acarbose acts as a potent competitive inhibitor of intestinal brush border alpha glucosidases that are essential for the breakdown of starches, dextrins, maltose, and sucrose to absorbable monosaccharides (Fig. 3). (antiaging-systems.com)
  • After oral application of acarbose, human intestinal α-glucosidases are inhibited, which leads to a retarded release of monosaccharides. (frontiersin.org)
  • In US studies including acarbose doses up to the maximum approved dose of 100 mg t.i.d., treatment-emergent elevations of AST and/or ALT at any level of severity were similar between acarbose-treated patients and placebo-treated patients (p ≥ 0.496). (wikidoc.org)
  • 211 (31%) of 682 patients in the acarbose group and 130 (19%) of 686 on placebo discontinued treatment early. (nih.gov)
  • RESEARCH DESIGN AND METHODS: Elderly patients with type 2 diabetes were randomly treated in a double-blind fashion with placebo (n = 23) or acarbose (n = 22) for 12 months. (diabetesjournals.org)
  • Neither the placebo nor acarbose altered leptin concentrations. (diabetesjournals.org)
  • There were only minor changes in body weight during the l6-week follow-up: decrease in the placebo group (change −0.5 kg/m 2 , P = 0.07) and acarbose (change −0.7 kg/m 2 , P = 0.046) and increase in the glibenclamide group (change 0.8 kg/m 2 , P = 0.27). (diabetesjournals.org)
  • Patients in each treatment group were randomly assigned to either acarbose or placebo for 1 year. (nih.gov)
  • Eighty-seven percent of patients receiving acarbose and 92% of those receiving placebo were included in the efficacy analysis (n = 316). (nih.gov)
  • For the high CV risk subgroups, acarbose treatment dominated placebo (i.e. acarbose was more effective, less costly). (diva-portal.org)
  • Patients were allocated to acarbose ( n = 973), titrated to a maximum dose of 100 mg 3 times/d, or placebo ( n = 973). (acpjc.org)
  • Acarbose more effectively maintained glycemic control in patients with established type 2 diabetes mellitus on preexisting therapy but had higher rates of noncompliance and adverse effects than did placebo. (acpjc.org)
  • After 6 weeks, 172 patients were assigned to acarbose and 182 to placebo. (acpjc.org)
  • More symptoms of abdominal cramps and discomfort (25% vs 9%), diarrhea (44% vs 20%), and flatulence (73% vs 39%) occurred in patients receiving acarbose than in those receiving placebo. (acpjc.org)
  • Chiasson and colleagues compared acarbose with placebo in a large group of patients whose diabetes was moderately well controlled by diet, oral hypoglycemic agents, or insulin (mean hemoglobin A 1c levels were within 2% of the normal range). (acpjc.org)
  • Acarbose comes as a tablet to take by mouth. (medlineplus.gov)
  • Both acarbose and miglitol come in a tablet you take by mouth. (healthline.com)
  • When you're using acarbose, candy or tablet sugar (sucrose) may not work as well as dextrose to raise your blood sugar quickly. (blogspot.com)
  • Europe as a combination metformin acarbose possible function combination for effects. (argilawholesale.com)
  • Once not it seems to help fit the combination metformin acarbose swiffer exercise reactivity fits now in common meals, cheapest directly not could be powderhd to another, less daily metformin. (argilawholesale.com)
  • Drfinition metformin side risk doses good, combination metformin acarbose in costs metformin formulas treating side los metformin mdtformin advantage calcium. (argilawholesale.com)
  • Metformin is a infertility 2 cfcl metformin, acarbose metformin combination and should helps metformin to respond also to use. (argilawholesale.com)
  • For example, foods containing sucrose often cause abdominal discomfort or diarrhoea in people taking acarbose. (netdoctor.co.uk)
  • The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of blood pressure after eating), which can result in falls. (clinicaltrials.gov)
  • Differing effects can be expected, since glibenclamide acts via stimulation of insulin secretion, whereas acarbose inhibits alpha-glucosidases of the small intestine and has no direct effect on insulin levels. (diabetesjournals.org)
  • Acarbose is an alpha-glucosidase inhibitor, the enzyme in your small intestine that chops up starch into sugar, almost immediately. (aircus.com)
  • Since acarbose prevents the digestion of complex carbohydrates, the drug should be taken at the start of main meals (taken with first bite of meal). (wikipedia.org)
  • Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. (cardiosmart.org)
  • Acarbose helps to control your blood sugar levels in conjunction with diet, exercise, weight loss and other measures by slowing down the digestion of carbohydrates (complex sugars) from your diet. (nps.org.au)
  • Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor acarbose (BAY g 5421). (abcam.com)
  • Acarbose works by slowing the body's digestion of carbohydrates so that blood sugar levels won't surge upward after a meal. (health-care-information.org)
  • Acarbose slows the digestion of carbohydrates in the body. (blogspot.com)
  • Where Can You Order Acarbose 25mg Cheap. (lanyrd.com)
  • More than 100 studies have proven the effectiveness of Acarbose - in particular its ability to help delay the progression of diabetes and fight against cardiovascular complications. (antiaging-systems.com)
  • The homogeneity of the study population could limit generalizability, as ethnic groups more frequently encountered in the United States, for example African Americans or Hispanic Americans, might have dietary habits that could affect the tolerability, and thus the effectiveness, of acarbose. (thefreelibrary.com)
  • The effectiveness of acarbose became apparent at 1 year. (thefreelibrary.com)
  • What is the effectiveness of acarbose for maintaining glycemic control in patients receiving established therapy for type 2 diabetes mellitus? (acpjc.org)
  • To evaluate the effectiveness and safety of acarbose in improving glycemic control in patients with type 2 diabetes mellitus. (acpjc.org)
  • SE50/110 led to the identification of gene products involved in acarbose metabolism. (harvard.edu)
  • To understand how acarbose works, we need to review a few basics of carbohydrate metabolism. (antiaging-systems.com)
  • Although maltose is an important building block of acarbose, the maltose/maltodextrin metabolism has not been studied in Actinoplanes sp. (frontiersin.org)
  • In Substrat-Bindungsstudien konnte für das Bindeprotein AcbH eine Interaktion mit Acarbose und längerkettigen Derivaten, nicht jedoch mit Maltose/Maltodextrinen beobachtet werden. (hu-berlin.de)
  • Surface plasmon resonance analysis showed that the substrate binding protein AcbH binds acarbose and longer derivatives, but not maltose and maltodextrins. (hu-berlin.de)
  • Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. (frontiersin.org)
  • SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. (frontiersin.org)
  • The first crystal form was obtained by crystallisation of BHA at room temperature in the presence of acarbose and maltose - data was collected at cryogenic temperatures to a resolution of 1.9 Å. (dtu.dk)
  • But on a patient or cheap generic acarbose uk, he is instead at your tympanites, and he feels every plenty you give him far through him. (websiteribbon.com)
  • Acarbose can be used on its own to treat people with type 2 diabetes whose blood sugar has not been controlled sufficiently by diet, exercise and weight loss alone. (netdoctor.co.uk)
  • Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. (wikipedia.org)
  • However, a recent large study concludes "acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes. (wikipedia.org)
  • Acarbose is used to treat type 2 diabetes. (cardiosmart.org)
  • Acarbose is used together with diet and exercise to treat type 2 diabetes. (uwhealth.org)
  • Acarbose is an alpha-glucosidase inhibitor that is FDA approved for the treatment of type 2 diabetes mellitus . (wikidoc.org)
  • Acarbose is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus . (wikidoc.org)
  • Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. (nih.gov)
  • Acarbose delays onset of type 2 diabetes mellitus. (nih.gov)
  • Acarbose for type 2 diabetes prevention. (nih.gov)
  • ACARBOSE (AY car bose) helps to treat type 2 diabetes. (ahealthyme.com)
  • Acarbose can be used alone to treat type II diabetes or can be combined with sulfonylureas such as Glyburide (Diabeta) or Metformin (Glucophage) or with insulin. (health-care-information.org)
  • Acarbose may also help people suffering pre-diabetes - the precursor to Type 2. (antiaging-systems.com)
  • Seventeen patients with type 2 diabetes were treated with acarbose and sixteen with pioglitazone for three months. (nii.ac.jp)
  • In conclusion, acarbose increases serum concentrations of total adiponectin without preference of the high molecular weight isoform in type 2 diabetic patients. (nii.ac.jp)
  • S.v. Acarbose delays onset of type 2 diabetes mellitus. (thefreelibrary.com)
  • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. (thefreelibrary.com)
  • RESULT Patients treated with acarbose were less likely to develop type 2 diabetes after 3.3 years (17% vs 26%, numbers needed to treat = 11, P = .0003). (thefreelibrary.com)
  • The primary purpose of this study is to evaluate the efficacy of voglibose versus acarbose combined with Metformin in patients with type 2 diabetes mellitus (T2DM) by evaluating levels of glycosylated hemoglobin. (clinicaltrials.gov)
  • Since 1990, acarbose has been used therapeutically for the treatment of type 2 diabetes. (agscientific.com)
  • Furthermore, acarbose appears to prevent or delay the progressive deterioration in pancreatic beta cells that routinely occurs in patients with Type 2 DM (Babasa-Lhoret and Chiasson, 1998). (antiaging-systems.com)
  • A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44). (acpjc.org)
  • Objectives: This study was done to find out the comparative efficacy of Miglitol and Acarbose as add on therapy in patients of type 2 Diabetes Mellitus. (scopemed.org)
  • Methods: This is a prospective, randomized, patient controlled, open label comparative study involving Type 2 diabetes patients, aged between 35-70 years of either sex of hyperglycaemic with PPBS >180mg%, FBS 0.05 signifying Miglitol to be better than Acarbose in terms of glycaemic controlin type 2 D.M. (scopemed.org)
  • OBJECTIVE The efficacy and tolerability of acarbose were examined in a postmarketing surveillance study of 27 803 patients with diabetes mellitus (26 044 were diagnosed as having type 2 diabetes) over a 12-week treatment period. (semanticscholar.org)
  • This report studies Acarbose in Global and China market, focuses on price, sales, revenue of each type in global China. (bigmarketresearch.com)
  • On basis of segments by manufacturers, this report focuses on the sales, price of each type, average price of Acarbose, revenue and market share, for key manufacturers. (bigmarketresearch.com)
  • Acarbose is prescribes to type 2 diabetes patients who cannot manage their condition by diet alone. (diabetor.com)
  • If you have type 2 diabetes, your healthcare provider may prescribe acarbose to help control your blood sugar levels. (emedtv.com)
  • Acarbose is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. (ndclist.com)
  • Acarbose inhibits enzymes (glycoside hydrolases) needed to digest carbohydrates, specifically, alpha-glucosidase enzymes in the brush border of the small intestines, and pancreatic alpha-amylase. (wikipedia.org)
  • Thus, besides acting as a carbophor acarbose also severely inhibits growth of competitors on maltodextrins. (hu-berlin.de)
  • tell your doctor and pharmacist if you are allergic to acarbose or any other drugs. (medlineplus.gov)
  • Acarbose, miglitol, and pramlintide are all drugs that help manage diabetes. (healthline.com)
  • Acarbose and miglitol are available as generic and brand-name drugs. (healthline.com)
  • Which drugs or supplements interact with acarbose? (medicinenet.com)
  • This study is a prospective randomized clinical trial to compare the endocrine and metabolic effects of two anti diabetic drugs (metformin vs. acarbose) in infertile overweight women with PCOS. (knowcancer.com)
  • The aim of present study is to compare the endocrine and metabolic effects of these two antidiabetic drugs (metformin vs. acarbose) in infertile overweight women with PCOS. (knowcancer.com)
  • To evaluate the long-term efficacy of acarbose, an alpha-glucosidase inhibitor, in improving glycemic control in patients with non-insulin-dependent diabetes mellitus. (nih.gov)
  • Acarbose with NDC 23155-149 is a a human prescription drug product labeled by Heritage Pharmaceuticals Inc. D/b/a Avet Pharmaceuticals Inc.. The generic name of Acarbose is acarbose. (ndclist.com)
  • In a study of 6 healthy men, less than 2% of an oral dose of acarbose was absorbed as active drug, while approximately 35% of total radioactivity from a 14 C-labeled oral dose was absorbed. (nih.gov)
  • What to do if you take missed a dose of Acarbose? (health-care-information.org)
  • The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus. (nih.gov)
  • This study confirms earlier reports of the efficacy of acarbose ( 1 ). (acpjc.org)
  • Evaluation of the efficacy and tolerability of acarbose in patients with diabetes mellitus : a postmarketing surveillance study. (semanticscholar.org)
  • When used in combination with insulin or other medications used to treat diabetes, acarbose may cause excessive lowering of blood sugar levels. (medlineplus.gov)
  • It is important that you and other members of your household understand this difference between acarbose and other medications used to treat diabetes. (medlineplus.gov)
  • Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. (cardiosmart.org)
  • Acarbose can interact with certain medications (see Drug Interactions With Acarbose ) . (emedtv.com)
  • Acarbose is sometimes combined with insulin or other diabetes medications. (blogspot.com)
  • In book, A Quick Understanding on What Doctors Are Prescribing: Pharmacology for Everyday People & Finding Alternative Medications , it described that acarbose works by competiting against carbohydrates found in food supposedly binding to enzyme in order to be digested, but now the place of binding is blocked by acarbose. (arthurwiz.com)
  • As expected from its mechanism of action, acarbose produced gastrointestinal side effects, including abdominal cramps, diarrhea, and flatulence. (acpjc.org)
  • After undergoing coronary angiography, CAD patients with IGT were randomly allocated to receive either acarbose 100 mg/d (C group) or no treatment group (B group) for 24 weeks. (alliedacademies.org)
  • Acarbose acts as a potent inhibitor of α-glucosidases and saccharases. (agscientific.com)
  • The author is also occasioned hj a hour of rapid part, as i have ascertained by the granulation of the neck into the discount acarbose. (websiteribbon.com)
  • The three-dimensional structure of the Aspergillus oryzae alpha-amylase (TAKA-amylase), in complex with the inhibitor acarbose, has been determined by X-ray crystallography at a resolution of 1. (rcsb.org)
  • In the present study we investigated effect of an α-glucosidase inhibitor, acarbose, together with pioglitazone, the only thiazolidine derivative available in Japan, on serum concentrations of adiponectin. (nii.ac.jp)
  • A possible explanation for the differing opinions is an observation that acarbose is significantly more effective in patients eating a relatively high carbohydrate Eastern diet. (wikipedia.org)
  • Acarbose has been demonstrated in numerous studies to significantly reduce HbA1c (Fig. 6). (antiaging-systems.com)
  • Acarbose did not significantly affect mean serum C-peptide or mean serum lipid levels. (nih.gov)
  • Acarbose significantly reduces the incidence of diabetes and CV events in IGT patients. (diva-portal.org)
  • Acarbose, miglitol, and pramlintide can cause side effects for some people, including dizziness and drowsiness. (healthline.com)
  • Side Effects From My Ulcerative Colitis Treatment purchasing acarbose mexico It's very important to address not just a single food but the whole pattern of consumption. (lanyrd.com)
  • The most frequent side-effects to acarbose treatment were flatulence and diarrhoea. (nih.gov)
  • Acarbose should be started at a low dose, with gradual dose escalation as described below, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. (health-care-information.org)
  • To minimize gastrointestinal side effects, patients randomized to acarbose were started at 50 mg/day and gradually increased to a maximum of 100 mg 3 times a day with meals or to the maximum tolerated dose. (thefreelibrary.com)
  • Chiasson and colleagues showed that although acarbose was a moderately effective agent for long-term treatment of NIDDM, its side effects may affect quality of life. (acpjc.org)
  • Only with this information can we advise our patients about whether the benefits of acarbose outweigh its side effects. (acpjc.org)
  • In view of its usually acceptable level of side effects that are, if they occur, mostly limited to transient gastrointestinal symptoms, acarbose could well be a strong future player in CV disease secondary prevention. (ox.ac.uk)
  • As with any medicine, there are possible side effects with acarbose. (emedtv.com)
  • She underwent metfrmin, acarbose treatment and best start. (argilawholesale.com)
  • There are no studies of acarbose treatment during pregnancy in humans. (medicinenet.com)
  • Acarbose is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. (cardiosmart.org)
  • Do not use acarbose if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). (uwhealth.org)
  • Every 3 months during your first year of treatment, your doctor will give you a blood test to check your liver and see how it is reacting to Acarbose. (health-care-information.org)
  • Treatment with acarbose and pioglitazone decreased HbA1c values by 0.49% and 0.63%, respectively. (nii.ac.jp)
  • For colocynth two animals of acarbose cost pbs use should be given every treatment pilocarpine, and for cases three of the college of pearance every day. (websiteribbon.com)
  • Before clinicians begin using acarbose as part of the standard therapy for diabetes, they should await the results of more clinically pertinent trials, that is, comparisons of acarbose treatment with efforts to optimize glycemic control with current therapy. (acpjc.org)
  • Acarbose is soluble in water and has a pK a of 5.1. (nih.gov)
  • Acarbose is soluble in water and has a pKa of 5.1. (rxlist.com)
  • Acarbose is soluble in water with partial methanol, ethanol DMF and DMSO solubility. (toku-e.com)
  • We aimed to compare clinical outcomes of adding acarbose versus sulfonylureas to metformin therapy in T2D patients. (medpagetoday.com)
  • Sulfonylureas and acarbose were respectively prescribed to 196,143 and 14,306 T2D patients during 2004-2015, who had been treated with metformin. (medpagetoday.com)
  • Acarbose has an excellent safety record but may initially cause flatulence, diarrhoea or abdominal pain. (antiaging-systems.com)
  • The major problem is that acarbose tends to cause flatulence and diarrhea. (acpjc.org)
  • Acarbose is a man-made oligosaccharide designed to slow down the actions of alpha-amylase and alpha-glucosidase enzymes, thereby slowing the appearance of sugar in the blood after a meal. (medicinenet.com)
  • Acarbose 50 mg given during Meal Test and Acarbose 25 mg taken with first bite of the next 3 meals. (clinicaltrials.gov)
  • In general, though, Acarbose should be taken three times daily at the start (with the first bite) of each main meal. (health-care-information.org)
  • Chiasson, et al (1994) also believed acarbose improved insulin sensitivity, based on their finding that patients taking acarbose experienced an upward trend in post-meal C-peptide levels. (antiaging-systems.com)
  • Do not use it if you had an allergic reaction to acarbose, or if you have cirrhosis or a bowel disorder such as colitis, Crohn disease, or a blockage in your bowel. (allinahealth.org)
  • The report then estimates 2016-2021 market development trends of Acarbose industry. (htfmarketreport.com)
  • Group and concerns contained in this web blood are acarbose metformin combination for amount effects sudafed and are still intended to be used to diagnose, treat, cure or prevent any father. (argilawholesale.com)
  • Because acarbose blocks the breakdown of table sugar and other complex sugars, fruit juice or other products containing these sugars will not help to increase blood sugar. (medlineplus.gov)
  • Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. (mayoclinic.org)
  • Acarbose defends your body by reducing blood sugar peaks. (antiaging-systems.com)
  • Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels (see Acarbose and Blood Sugar for more information) . (emedtv.com)