Acanthosis Nigricans: A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.Paraneoplastic Syndromes: In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.Lipodystrophy, Congenital Generalized: Congenital disorders, usually autosomal recessive, characterized by severe generalized lack of ADIPOSE TISSUE, extreme INSULIN RESISTANCE, and HYPERTRIGLYCERIDEMIA.Craniofacial Dysostosis: Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.Hand DermatosesSouthwestern United States: The geographic area of the southwestern region of the United States. The states usually included in this region are Arizona, California, Colorado, Nevada, New Mexico, Texas, and Utah.Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.Receptor, Fibroblast Growth Factor, Type 3: A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.Access to Information: Individual's rights to obtain and use information collected or generated by others.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Endocrine System: The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.Syndrome: A characteristic symptom complex.Melatonin: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.Dermatitis, Seborrheic: A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Sheltered Workshops: Protective places of employment for disabled persons which provide training and employment on a temporary or permanent basis.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Education, Veterinary: Use for general articles concerning veterinary medical education.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Schools, Veterinary: Educational institutions for individuals specializing in the field of veterinary medicine.Pathology, Veterinary: The field of veterinary medicine concerned with the causes of and changes produced in the body by disease.North AmericaDictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)
(1/88) A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene.

We have identified a novel fibroblast growth factor receptor 3 (FGFR3) missense mutation in four unrelated individuals with skeletal dysplasia that approaches the severity observed in thanatophoric dysplasia type I (TD1). However, three of the four individuals developed extensive areas of acanthosis nigricans beginning in early childhood, suffer from severe neurological impairments, and have survived past infancy without prolonged life-support measures. The FGFR3 mutation (A1949T: Lys650Met) occurs at the nucleotide adjacent to the TD type II (TD2) mutation (A1948G: Lys650Glu) and results in a different amino acid substitution at a highly conserved codon in the kinase domain activation loop. Transient transfection studies with FGFR3 mutant constructs show that the Lys650Met mutation causes a dramatic increase in constitutive receptor kinase activity, approximately three times greater than that observed with the Lys650Glu mutation. We refer to the phenotype caused by the Lys650Met mutation as "severe achondroplasia with developmental delay and acanthosis nigricans" (SADDAN) because it differs significantly from the phenotypes of other known FGFR3 mutations.  (+info)

(2/88) Clearance of acanthosis nigricans associated with the HAIR-AN syndrome after partial pancreatectomy: an 11-year follow-up.

We describe a woman with the syndrome characterised by hyperandrogenism, insulin resistance and acanthosis nigricans (the HAIR-AN syndrome), and an associated insulinoma (islet B-cell tumour), whose signs and symptoms cleared after partial pancreatectomy.  (+info)

(3/88) A quantitative scale of acanthosis nigricans.

OBJECTIVE: To develop and validate a scale for acanthosis nigricans (AN). RESEARCH DESIGN AND METHODS: Subjects were participants from the San Antonio Family Diabetes Study and the San Antonio Family Heart Study. A total of 406 subjects were independently examined for AN by at least two observers. Five locations were examined: the neck, axilla, elbows, knuckles, and knees. Interobserver concordance and kappa statistics were calculated to determine replicability of the scale. Comparisons of diabetes-related risk factors by AN score were also calculated. RESULTS: Only the neck had consistently high kappa statistics, and thus, other locations were excluded from further analyses. Elevated AN was strongly associated with elevated fasting insulin and BMI in both diabetic and nondiabetic subjects. Elevated AN was also strongly associated with elevated fasting glucose, systolic blood pressure, and diastolic blood pressure, and with decreased HDL in nondiabetic subjects. In diabetic subjects, elevated AN was associated with elevated total cholesterol. CONCLUSIONS: We have developed a scale for AN that is easy to use, has high interobserver reliability in Mexican Americans, and correlates well with fasting insulin and BMI. This scale will permit longitudinal and cross-sectional evaluation of AN and will permit the evaluation of AN as a trait in genetic studies.  (+info)

(4/88) Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice.

Several gain-of-function mutations in a receptor tyrosine kinase, fibroblast growth factor receptor 3 (FGFR3), cause dwarfism in humans. Two particularly severe dwarfisms, thanatophoric dysplasia type II (TDII) and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), are associated with glutamic acid (E) and methionine (M) substitutions at the K650 residue in the kinase domain. TDII is lethal at birth, whereas most of the SADDAN patients survive the perinatal period. However, FGFR3 with the SADDAN mutation is more activated than FGFR3 with the TDII mutation in vitro. To find out whether the K650M mutation also causes the SADDAN phenotype, we introduced the corresponding point mutation (K644M) into the mouse Fgfr3 gene. Heterozygous mutant mice show a phenotype similar to human SADDAN, e.g. the majority of the SADDAN mice survive the perinatal period. This suggests that the survival of SADDAN patients is indeed attributed to the K650M mutation in FGFR3. The long bone abnormalities in SADDAN mice are milder than the TDII model. In addition, overgrowth of the cartilaginous tissues is observed in the rib cartilage, trachea and nasal septum. The FGF ligand at the low concentration differentially activates Map kinase in primary chondrocyte cultures from wild-type and SADDAN mice. Comparisons of the molecular bases of the phenotypic differences in SADDAN and TDII mice may increase our understanding of the factors that influence the severity in these two related skeletal dysplasias.  (+info)

(5/88) HAIR-AN syndrome: a multisystem challenge.

HAIR-AN syndrome is an acronym for an unusual multisystem disorder in women that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The precipitating abnormality is thought to be insulin resistance, with a secondary increase in insulin levels and subsequent overproduction of androgens in the ovaries. Long periods of hyperinsulinism and, some suspect, hyperandrogenism can result in the cutaneous manifestation of acanthosis nigricans. Patients are often concerned about the physical manifestations of this disorder, including virilization and acanthosis nigricans, and may be less aware of systemic problems. Physicians should assess women with these problems for an underlying endocrine abnormality. Although a treatment regimen for the HAIR-AN syndrome has not been established, antiandrogen therapy and weight loss are useful.  (+info)

(6/88) Association of acanthosis nigricans with race and metabolic disturbances in obese women.

Acanthosis nigricans (AN) has been recognized as a marker of insulin resistance and diabetes mellitus. We have compared frequency of race and metabolic disturbances in obese women with several degrees of AN (AN group, N = 190) to a group without AN (non-AN group, N = 61) from a mixed racial population. The groups were similar regarding age and body mass index. All patients (except the diabetic patients) underwent an oral glucose tolerance test (75 g). The racial distribution of this population was 35.1% white, 37.8% mulatto and 27.1% black and the frequency of AN was 62.5, 82.1 and 83.8%, respectively, higher in black versus white (P = 0.003) and mulatto versus white (P = 0.002) women. The frequencies of diabetes mellitus and impaired glucose tolerance were 5.8 and 12.6% in the AN group and 1.6 and 8.2% in the non-AN group, respectively (P>0.05). Fasting glucose, beta cell function determined by the homeostasis model of assessment (HOMA), fasting insulin and insulin area under the curve were similar for the AN and non-AN groups. A higher HOMA insulin resistance was observed in the AN group compared to the non-AN group (P = 0.02) and in the subgroup of highest degree of AN compared to those with other degrees. The mean lipid levels and the frequency of dyslipidemia were similar for the two groups. AN was strongly associated with the black or mulatto rather than the white race, even after taking into account the effect of age, body mass index and HOMA insulin resistance.  (+info)

(7/88) Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs.

As dietary sources of gamma-linolenic acid [GLA; 18:3(n-6)], borage oil (BO; 24-25 g/100 g GLA) and evening primrose oil (PO; 8-10 g/100 g GLA) are efficacious in treating skin disorders. The triglycerol stereospecificity of these oils is distinct, with GLA being concentrated in the sn-2 position of BO and in the sn-3 position of PO. To determine whether the absolute level and/or the triglycerol stereospecificity of GLA in oils affect biological efficacy, epidermal hyperproliferation was induced in guinea pigs by a hydrogenated coconut oil (HCO) diet for 8 wk. Subsequently, guinea pigs were fed diets of PO, BO or a mixture of BO and safflower oil (SO) for 2 wk. The mixture of BO and SO (BS) diet had a similar level of GLA as PO but with sn-2 stereospecificity. As controls, two groups were fed SO and HCO for 10 wk. Epidermal hyperproliferation was reversed by all three oils in the order of BO > BS > PO. However, proliferation scores of group PO were higher than of the normal control group, SO. The accumulations of dihomo-gamma-linolenic acid [DGLA; 20:3(n-6)], an elongase product of GLA, into phospholipids and ceramides, of 15-hydroxyeicosatrienoic acid (15-HETrE), the potent antiproliferative metabolite of DGLA, and of ceramides, the major lipid maintaining epidermal barrier, in the epidermis of group BO were greater than of groups BS and PO. Group BS had higher levels of DGLA, 15-HETrE and ceramides than group PO. With primary dependence on absolute levels, our data demonstrate that the antiproliferative efficacy of GLA in the epidermis is preferably exerted from sn-2 stereospecificity of GLA in BO.  (+info)

(8/88) An incomplete from of acanthosis nigricans.

The authors report a variation of the clinical picture of acanthosis nigricans in two patients with carcinoma of the stomach.  (+info)

*  Paraneoplastic syndrome
The following diseases manifest by means of mucocutaneous dysfunction: acanthosis nigricans, dermatomyositis, Leser-Trélat sign ...
*  Crouzonodermoskeletal syndrome
Herman, TE; Sargar, K; Siegel, MJ (Feb 2014). "Crouzono-dermo-skeletal syndrome, Crouzon syndrome with acanthosis nigricans ... People with Crouzonodermoskeletal syndrome have acanthosis nigricans, a skin condition characterized by thick, dark, velvety ... and Crouzon syndrome with acanthosis nigricans". Endocr Rev. 21 (1): 23-39. doi:10.1210/er.21.1.23. PMID 10696568. CS1 maint: ... during development and a skin condition called acanthosis nigricans. Some of the signs and symptoms of Crouzonodermoskeletal ...
*  Acanthosis nigricans
... acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms. Acanthosis nigricans may present ... This form of acanthosis nigricans is more likely to involve mucous membranes (25-50% of cases) Malignant acanthosis nigricans ... Acanthosis nigricans maligna may resolve if the causative tumor is successfully removed. Acanthosis nigricans is likely to ... Malignant acanthosis nigricans refers to acanthosis nigricans occurring as a paraneoplastic syndrome associated with a cancer. ...
*  Severe achondroplasia with developmental delay and acanthosis nigricans
2015). Acanthosis nigricans. Retrieved from http://www.mayoclinic.org/diseases-conditions/acanthosis-nigricans/basics/ ... Acanthosis nigricans is a skin condition in which areas of the skin is of a dark and velvety discoloration, often seen in the ... Within those affected by SADDAN, acanthosis nigricans develops early on, usually in infancy or early childhood. The mutated ... Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), is a very rare genetic disorder. This ...
*  Dermatosis neglecta
... acanthosis nigricans; and Vagabond's disease. The term was first coined by Poskitt and coworkers in 1995. Ruiz-Maldonado R, ...
*  Acanthosis
... nigricans Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). ... Acanthosis is diffuse epidermal hyperplasia (thickening of the skin). It implies increased thickness of the Malpighian layer ( ... ISBN 0-7216-0187-1. M. S. Stone; T. L. Ray (September 1995). "Acanthosis". DermPathTutor. Department of Dermatology, University ...
*  List of OMIM disorder codes
... with acanthosis nigricans; 610549; INSR Diabetes mellitus, ketosis-prone; 612227; PAX4 Diabetes mellitus, neonatal, with ... CRLF1 Crouzon syndrome with acanthosis nigricans; 612247; FGFR3 Crouzon syndrome; 123500; FGFR2 Cryptorchidism, bilateral; ...
*  Robert A. Schwartz
Feb 2007). "Acral acanthosis nigricans (acral acanthotic anomaly)". J Am Acad Dermatol. 56 (2): 349-50. doi:10.1016/j.jaad. ... In 1994 he devised the commonly-accepted classification for acanthosis nigricans. He has served as editor of the Acta ... In 1981 he first described acral acanthotic anomaly (acral acanthosis nigricans). In 1980 Edmund Klein, Schwartz and associates ... In 1981 he discovered and described acral acanthosis nigricans. ...
*  Lelis syndrome
Steiner CE, Cintra ML, Marques-de-Faria AP (December 2002). "Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome)". ... List of cutaneous conditions Samdani AJ (October 2004). "Ectodermal dysplasia with acanthosis nigricans (Lelis' syndrome)". J ... with acanthosis nigricans. Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual ...
*  Florid cutaneous papillomatosis
Malignant acanthosis nigricans may also become evident, many times with the sudden eruption of multiple seborrheic keratoses, ... Tsai, Yu-Ju; Tsai, Yi-Jeng; Chuan, Ming-Tuo; Hu, Shu-Ling (2004), "The Combination of Tripe Palms, Acanthosis Nigricans and ... Florid cutaneous papillomatosis, malignant acanthosis nigricans, and the sign of Leser-Trélat may be highlighted as part of a ... May 2000). "Florid cutaneous and mucosal papillomatosis with acanthosis nigricans revealing a primary lung cancer". J Eur Acad ...
*  Hyperinsulinemia
Metabolic syndrome (Syndrome X) Acanthosis nigricans Modan, Michaela; Halkin H; Almog S; Lusky A; Eshkol A; Shefi M; Shitrit A ...
*  Insulin receptor
Patients with insulin resistance may display acanthosis nigricans. A few patients with homozygous mutations in the INSR gene ...
*  Hair-an syndrome
Obesity is also one such symptoms in some women, and is also marked in women affected by PCOS, hirsutism, acanthosis nigricans ... HAIR-AN syndrome consists of hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN). It is a rare ... "Case Report Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome". Azziz, Ricardo; Carmina, Enrico; Dewailly, ... "Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic ...
*  Jeffrey Scott Flier
... acanthosis nigricans, and the polycystic ovary syndrome (type a insulin resistance)". The New England Journal of Medicine. 319 ... Acanthosis Nigricans, and the Polycystic Ovary Syndrome (Type A Insulin Resistance)". New England Journal of Medicine. 319 (23 ... "The Syndromes of Insulin Resistance and Acanthosis Nigricans". New England Journal of Medicine. 294 (14): 739-745. doi:10.1056/ ...
*  Hyperpigmentation
Acanthosis nigricans-hyperpigmentation of intertriginous areas associated with insulin resistance. Melasma, also known as ...
*  Diabetes mellitus type 2
Other complications include acanthosis nigricans, sexual dysfunction, and frequent infections. The development of type 2 ...
*  Gestational diabetes
for example in those with polycystic ovarian syndrome or acanthosis nigricans). Non-challenge blood glucose tests involve ...
*  Familial partial lipodystrophy
Features included fat loss, severe insulin resistance, fatty liver, acanthosis nigricans and diabetes. This not known with ... Other conditions associated with this condition include acanthosis nigricans, fatty liver, hypertriglyceridemia and polycystic ...
*  Rabson-Mendenhall syndrome
Symptoms include growth abnormalities of the head, face and nails, along with the development of acanthosis nigricans. ... Prognathism and very thick fingernails as well as acanthosis nigricans were also described. Insulin-resistant diabetes ... A skin abnormality known as acanthosis nigricans, which involves a discoloration (hyperpigmentation) and "velvety" thickening ( ...
*  List of cutaneous conditions
Acanthosis nigricans associated with malignancy (acanthosis nigricans type I) Acanthosis nigricans associated with obesity, ... acanthosis nigricans type III) Acral acanthosis nigricans (acral acanthotic anomaly) Acral dry gangrene Acromegaly Addison's ... acanthosis nigricans type II) Growth hormone deficiency Hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR ... Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory ...
*  Obesity-associated morbidity
Obesity is associated with the incidence of stretch marks, acanthosis nigricans, lymphedema, cellulitis, hirsutism, and ...
*  Stomach cancer
A condition of darkened hyperplasia of the skin, frequently of the axilla and groin, known as acanthosis nigricans, is ... "Oral acanthosis nigricans, tripe palms and sign of leser-trelat in a patient with gastric adenocarcinoma". International ...
*  Faisal Masud
Acanthosis Nigricans in non-insulin dependent diabetes mellitus, Specialist:, Vol. 11, No. 3, April-June 1995 14. Insulin ...
*  Melanocyte-stimulating hormone
... such as acanthosis nigricans in the axilla. Most people with primary Addison's disease have darkening (hyperpigmentation) of ...
*  Fibroblast growth factor receptor 3
"Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu ...
*  Cushing's syndrome
Insulin resistance is accompanied by skin changes such as acanthosis nigricans in the axilla and around the neck, as well as ...
*  Beare-Stevenson cutis gyrata syndrome
... acanthosis nigricans) are sometimes found on the hands and feet and in the groin. Additional signs and symptoms of Beare- ...
Acanthosis Nigricans  Acanthosis Nigricans
... , or AN, is a darkening and thickening of the skin that can be a sign of certain other medical conditions. ... What Is Acanthosis Nigricans?. If you have acanthosis nigricans (ah-kan-THO-sis NY-gruh-kans), you're probably concerned about ... What Causes Acanthosis Nigricans?. People who are overweight or obese are more likely to develop acanthosis nigricans, which ... Treatment for Acanthosis Nigricans. If your doctor finds that your acanthosis nigricans isn't connected to a more serious ...
more infohttp://kidshealth.org/Nemours/en/teens/acanthosis.html
Acanthosis Nigricans in Dogs: Blackening Skin  Acanthosis Nigricans in Dogs: Blackening Skin
Aquired Acanthosis Nigricans. The acanthosis nigricans may also have a secondary form and may occur due to an excess of pigment ... Genetic Acanthosis Nigricans. If the acanthosis nigricans is genetic, it will most likely affect dog breeds such as the ... Acanthosis Nigricans Detection. The diagnosis of acanthosis nigricans will be done through evaluating the dog's history and by ... The secondary acanthosis nigricans may be treated while primary acanthosis nigricans may be controlled through medication. ...
more infohttps://www.vetinfo.com/acanthosis-nigricans-in-dogs-blackening-skin.html
Acanthosis Nigricans: Risk Factors  Acanthosis Nigricans: Risk Factors
Risk factors for acanthosis nigricans include: * Lymphoma * Oral contraceptives * Obesity ... ... Another name for Acanthosis Nigricans is Acanthosis Nigricans. ... Acanthosis Nigricans Risk Factors. Risk factors for acanthosis ... PubMed Acanthosis Nigricans References *Hermanns-Le T, Hermanns JF, Pierard GE. Juvenile acanthosis nigricans and insulin ... Continue to Acanthosis Nigricans Symptoms Last Updated: Feb 21, 2008 References Authors: Stephen J. Schueler, MD; John H. ...
more infohttp://www.freemd.com/acanthosis-nigricans/risk-factors.htm
Acanthosis Nigricans - Causes, Symptoms and Treatments  Acanthosis Nigricans - Causes, Symptoms and Treatments
Acanthosis nigricans is commonly found in individuals with diabetes. Learn more about its causes, symptoms and treatments today ... Who develops acanthosis nigricans?. The NIH asserts that while acanthosis nigricans can affect healthy people, it usually ... How is acanthosis nigricans treated?. Treating the underlying condition causing acanthosis nigricans may allow the condition ... If the acanthosis nigricans was linked to another cause, treating that problem could help your skin return to normal. For ...
more infohttp://www.diabetesmonitor.com/education-center/diabetes-basics/acanthosis-nigricans.htm
Acanthosis nigricans | definition of acanthosis nigricans by Medical dictionary  Acanthosis nigricans | definition of acanthosis nigricans by Medical dictionary
What is acanthosis nigricans? Meaning of acanthosis nigricans medical term. What does acanthosis nigricans mean? ... Looking for online definition of acanthosis nigricans in the Medical Dictionary? acanthosis nigricans explanation free. ... Acanthosis nigricans: Acanthosis nigricans is a cosmetic condition strongly associated with insulin resistance in which there ... The patients were graded according to acanthosis nigricans severity on a 1-4 scale.. Acanthosis nigricans severity flags ...
more infohttp://medical-dictionary.thefreedictionary.com/acanthosis+nigricans
Acanthosis Nigricans  Acanthosis Nigricans
"Acanthosis Nigricans" (open studies are recruiting volunteers) and 7 "Acanthosis Nigricans" studies with "all" status. Visit ... Acanthosis nigricans in the setting of niacin therapy. Author(s): Rachael Hartman, Taylor Defelice, Julia Tzu, Shane Meehan, ... Association of acanthosis nigricans and skin tags with insulin resistance. Author(s): Mariana Tremel Barbato, Paulo Ricardo ... Unilateral nevoid acanthosis nigricans treated with CO2 laser. Author(s): Manuel António Campos, Paulo Varela, Armando Baptista ...
more infohttp://diseaseinfosearch.org/Acanthosis+Nigricans/90
Acanthosis Nigricans - Medvin2u.netMedvin2u.net  Acanthosis Nigricans - Medvin2u.netMedvin2u.net
Acanthosis Nigricans,a skin disorder of the neck,axilla and over the joints of the fingers and toes,Causes,Symptoms,Diagnosis ... Post Tagged with Acanthosis nigricans, Causes of Acanthosis nigricans, Diagnosis of Acanthosis nigricans, Management of ... Acanthosis nigricans. Acanthosis nigricans is a skin disorder in which there is darker, thick, velvety skin in body folds and ... Management of Acanthosis Nigricans. Because acanthosis nigricans usually only changes the skin's appearance, no treatment is ...
more infohttp://medvin2u.net/acanthosis-nigricans/
What Is Dermatology - Acanthosis Nigricans - Medicalrealm  What Is Dermatology - Acanthosis Nigricans - Medicalrealm
Acanthosis nigricans may present as darkening of the skin which appear to be thickens and dirty as well as velvety in ... What Is Dermatology - Acanthosis Nigricans. Acanthosis Nigricans Acanthosis nigricans may present as darkening of the skin ... There are 5 forms of acanthosis nigricans. These include type 1, type 2, type 3, type 4 and type 5. Type 1 acanthosis nigricans ... Type 3 pseudo acanthosis nigricans is due to obesity, metabolic syndrome and darker pigmentation. There will be velvety patch ...
more infohttp://www.medicalrealm.net/what-is-dermatology---acanthosis-nigricans.html
Acanthosis Nigricans  Acanthosis Nigricans
... , or AN, is a darkening and thickening of the skin that can be a sign of certain other medical conditions. ... What Is Acanthosis Nigricans?. If you have acanthosis nigricans (ah-kan-THO-sis NY-gruh-kans), you're probably concerned about ... What Causes Acanthosis Nigricans?. People who are overweight or obese are more likely to develop acanthosis nigricans, which ... Treatment for Acanthosis Nigricans. If your doctor finds that your acanthosis nigricans isn't connected to a more serious ...
more infohttp://kidshealth.org/KHovnanian/en/teens/acanthosis.html
Acanthosis Nigricans Skin Condition  Acanthosis Nigricans Skin Condition
Acanthosis nigrincans is hyperpigmentation and hyperkeratosis of the skin, which may be indicative of an underlying health ... http://www.dermnetnz.org/topics/acanthosis-nigricans/. *https://www.aad.org/public/diseases/color-problems/acanthosis-nigricans ... The aim of acanthosis nigricans treatment is to establish and manage the underlying cause of disease in an appropriate manner. ... For patients with acanthosis nigricans caused by an inherited genetic factor, the condition usually stabilizes or regresses ...
more infohttps://www.news-medical.net/health/Acanthosis-Nigricans-Skin-Condition.aspx
Acanthosis Nigricans: Background, Pathophysiology, Etiology  Acanthosis Nigricans: Background, Pathophysiology, Etiology
By 1909, acanthosis nigricans had been described in approximately 50 patients and was suspected to be associated wit... ... the first documented case of acanthosis nigricans was in 1889 in Germany as described by Unna and Pollitzer. ... Although Addison may have seen a case of acanthosis nigricans (AN) before 1885 and misdiagnosed it as Addison disease, ... Syndromic acanthosis nigricans. Syndromic acanthosis nigricans is the name given to acanthosis nigricans that is associated ...
more infohttps://emedicine.medscape.com/article/1102488-overview
Acanthosis nigricans - Wikipedia  Acanthosis nigricans - Wikipedia
"acanthosis nigricans" at Dorland's Medical Dictionary *^ a b c d e f g h i j Habif, Thomas P. (2009). Clinical dermatology (5th ... Malignant acanthosis nigricans refers to acanthosis nigricans occurring as a paraneoplastic syndrome associated with a cancer. ... For example, obesity-related acanthosis nigricans will improve with weight loss, and drug-induced acanthosis nigricans is ... acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms.[5][6] ...
more infohttps://en.m.wikipedia.org/wiki/Acanthosis_nigricans
Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome  Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome
... A. H. Dédjan, A. Chadli, S. El Aziz, and A. Farouqi ... R. L. Barbieri and K. J. Ryan, "Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common ...
more infohttps://www.hindawi.com/journals/crie/2015/193097/ref/
Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome  Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome
... A. H. Dédjan, A. Chadli, S. El Aziz, and A. Farouqi ... The maternal antecedent of the metabolic syndrome present in the patient as well as the presence of acanthosis nigricans well ... Several etiologies are incriminated but the hyperandrogenism-insulin resistance-acanthosis nigricans syndrome is rare. ... R. L. Barbieri and K. J. Ryan, "Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common ...
more infohttps://www.hindawi.com/journals/crie/2015/193097/
A to Z: Acanthosis Nigricans  A to Z: Acanthosis Nigricans
... Acanthosis nigricans (ay-can-THO-sis NYG-ruh-cans) is a condition ... Acanthosis nigricans is more common in people who have high levels of the hormone insulin in their blood due to insulin ... In acanthosis nigricans, thick, dark, and sometimes streaky patches appear on the skin. The patches are harmless and aren't ... However, acanthosis nigricans also can be hereditary and occur in kids and teens who are otherwise healthy. ...
more infohttps://www.rchsd.org/health-articles/a-to-z-acanthosis-nigricans/
Acanthosis Nigricans - NORD (National Organization for Rare Disorders)  Acanthosis Nigricans - NORD (National Organization for Rare Disorders)
Subdivisions of Acanthosis Nigricans. *Acanthosis Nigricans With Insulin Resistance Type A. *Acanthosis Nigricans With Insulin ... www.mayoclinic.com/health/acanthosis-nigricans/DS00653/DSECTION=5. Levine N, Baron J. Acanthosis Nigricans. emedicine. Last ... Acanthosis nigricans is a condition that may become apparent at any age. Many benign forms develop during childhood or puberty ... Acanthosis nigricans is most commonly found in people of African descent and some cases are genetically inherited as an ...
more infohttps://rarediseases.org/rare-diseases/acanthosis-nigricans/
Acanthosis Nigricans - Merck Veterinary Manual  Acanthosis Nigricans - Merck Veterinary Manual
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
more infohttp://www.merckvetmanual.com/en-ca/integumentary-system/acanthosis-nigricans
Acanthosis nigricans  Acanthosis nigricans
L83 - Acanthosis nigricans. SNOMEDCT:. 402599005 - Acanthosis nigricans. Look For. Subscription Required. Diagnostic Pearls. ... Acanthosis nigricans. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Get VisualDx Mobile. There are VisualDx ... Acanthosis nigricans in Adult. See also in: Anogenital. Print Patient Handout Images (92) ... Acanthosis nigricans (AN) is a localized skin disorder manifesting with hyperpigmented, velvety plaques typically located in ...
more infohttps://www.visualdx.com/visualdx/diagnosis/acanthosis-nigricans?moduleId=101&diagnosisId=51010
Acanthosis nigricans  Acanthosis nigricans
L83 - Acanthosis nigricans. SNOMEDCT:. 402599005 - Acanthosis nigricans. Look For. Subscription Required. Diagnostic Pearls. ... Acanthosis nigricans. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, Medication, or ... Acanthosis nigricans in Adult. See also in: Anogenital. Print Patient Handout Images (97) ... Acanthosis nigricans (AN) is a localized skin disorder manifesting with hyperpigmented, velvety plaques typically located in ...
more infohttps://www.visualdx.com/visualdx/diagnosis/acanthosis+nigricans?diagnosisId=51010&moduleId=101
Microscopic acanthosis nigricans in type 2 diabetes.  - PubMed - NCBI  Microscopic acanthosis nigricans in type 2 diabetes. - PubMed - NCBI
Microscopic acanthosis nigricans in type 2 diabetes.. McManus RM1, Gottschalk R, Alanen K, Shum DT, Grundy P. ... Microscopic acanthosis nigricans was found in similar numbers of people with DM when compared with C. Fasting insulin levels ... Acanthosis nigricans (AN) has been associated with insulin resistance. Individuals with type 2 diabetes are insulin-resistant ... Height, weight, waist/hip measures, and a clinical survey for acanthosis were recorded. A 2-mm skin biopsy from midaxilla of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=11907848
  • The exam revealed a patient, normotensive with a body mass index at 30 kg/m 2 and a waist measurement of 120 cm, a severe hirsutism assessed to be 29 according to Ferriman Gallwey scale, virilisation signs of male morphotype, clitoridic hypertrophy and frontal alopecia, and an acanthosis nigricans behind the neck, in the armpits and elbows. (hindawi.com)
  • The characteristic sign of acanthosis nigricans is patches of skin that become thicker, darker in color and develop a velvety texture. (news-medical.net)
  • Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin . (wikipedia.org)
  • Acanthosis nigricans (AN) is a localized skin disorder manifesting with hyperpigmented, velvety plaques typically located in flexural and intertriginous regions. (visualdx.com)
  • Acanthosis nigricans (AN) is a cutaneous disorder manifested by symmetric, hypertrophic, papillomatous, velvety, hyperpigmented plaques commonly found on flexural and intertriginous areas. (bmj.com)
  • Hi, I have lost 70lbs this year (2005) and my acanthosis seems to have been aggravated, but only under my armpits. (lowcarber.org)
  • Acanthosis nigrincans is hyperpigmentation and hyperkeratosis of the skin, which may be indicative of an underlying health condition. (news-medical.net)
  • Acanthosis nigricans (AN) is characterized by increased coloration or pigmentation (hyperpigmentation) and abnormal thickening of the skin. (rarediseases.org)
  • Acral acanthotic anomaly refers to a variant of acanthosis nigricans limited to the elbows, knees, knuckles, and dorsal surfaces of the feet, in the absence of any other findings, in otherwise healthy individuals. (wikipedia.org)
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Acanthosis nigricans muscle cramps acral enlargement. (nih.gov)
  • A female presenting at age 11 years with acanthosis nigricans and extreme postprandial hyperinsulinemia was heterozygous for a premature stop mutation (R363X) in TBC1D4 . (pnas.org)
  • Microscopic acanthosis nigricans was found in similar numbers of people with DM when compared with C. Fasting insulin levels most strongly predicted the presence of AN in C, while no significant predictors of AN were found in the population with DM. (nih.gov)