Acanthosis Nigricans: A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.Paraneoplastic Syndromes: In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.Lipodystrophy, Congenital Generalized: Congenital disorders, usually autosomal recessive, characterized by severe generalized lack of ADIPOSE TISSUE, extreme INSULIN RESISTANCE, and HYPERTRIGLYCERIDEMIA.Craniofacial Dysostosis: Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.Hand DermatosesSouthwestern United States: The geographic area of the southwestern region of the United States. The states usually included in this region are Arizona, California, Colorado, Nevada, New Mexico, Texas, and Utah.Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.Receptor, Fibroblast Growth Factor, Type 3: A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.Oligomenorrhea: Abnormally infrequent menstruation.Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.Lipodystrophy: A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.Rhizopus: A genus of zygomycetous fungi of the family Mucoraceae, order MUCORALES, a common saprophyte and facultative parasite of mature fruits and vegetables. It may cause cerebral mycoses in diabetes and cutaneous infection in severely burned patients.Access to Information: Individual's rights to obtain and use information collected or generated by others.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Root Cause Analysis: Multi-step systematic review process used for improving safety by investigation of incidents to find what happened, why it happened, and to determine what can be done to prevent it from happening again.Melatonin: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.Dermatitis, Seborrheic: A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Sheltered Workshops: Protective places of employment for disabled persons which provide training and employment on a temporary or permanent basis.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Education, Veterinary: Use for general articles concerning veterinary medical education.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Schools, Veterinary: Educational institutions for individuals specializing in the field of veterinary medicine.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).POEMS Syndrome: A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)School Health Services: Preventive health services provided for students. It excludes college or university students.Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Students: Individuals enrolled in a school or formal educational program.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.ColoradoOverweight: A status with BODY WEIGHT that is above certain standard of acceptable or desirable weight. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal "over fat".Groin: The external junctural region between the lower part of the abdomen and the thigh.Animal Identification Systems: Procedures for recognizing individual animals and certain identifiable characteristics pertaining to them; includes computerized methods, ear tags, etc.Neuralgia, Postherpetic: Pain in nerves, frequently involving facial SKIN, resulting from the activation the latent varicella-zoster virus (HERPESVIRUS 3, HUMAN). The two forms of the condition preceding the pain are HERPES ZOSTER OTICUS; and HERPES ZOSTER OPHTHALMICUS. Following the healing of the rashes and blisters, the pain sometimes persists.Herpes Zoster: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.Herpes Zoster Vaccine: An attenuated vaccine used to prevent and/or treat HERPES ZOSTER, a disease caused by HUMAN HERPESVIRUS 3.Herpes Zoster Ophthalmicus: Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. (1/88)
We have identified a novel fibroblast growth factor receptor 3 (FGFR3) missense mutation in four unrelated individuals with skeletal dysplasia that approaches the severity observed in thanatophoric dysplasia type I (TD1). However, three of the four individuals developed extensive areas of acanthosis nigricans beginning in early childhood, suffer from severe neurological impairments, and have survived past infancy without prolonged life-support measures. The FGFR3 mutation (A1949T: Lys650Met) occurs at the nucleotide adjacent to the TD type II (TD2) mutation (A1948G: Lys650Glu) and results in a different amino acid substitution at a highly conserved codon in the kinase domain activation loop. Transient transfection studies with FGFR3 mutant constructs show that the Lys650Met mutation causes a dramatic increase in constitutive receptor kinase activity, approximately three times greater than that observed with the Lys650Glu mutation. We refer to the phenotype caused by the Lys650Met mutation as "severe achondroplasia with developmental delay and acanthosis nigricans" (SADDAN) because it differs significantly from the phenotypes of other known FGFR3 mutations. (+info)Clearance of acanthosis nigricans associated with the HAIR-AN syndrome after partial pancreatectomy: an 11-year follow-up. (2/88)
We describe a woman with the syndrome characterised by hyperandrogenism, insulin resistance and acanthosis nigricans (the HAIR-AN syndrome), and an associated insulinoma (islet B-cell tumour), whose signs and symptoms cleared after partial pancreatectomy. (+info)A quantitative scale of acanthosis nigricans. (3/88)
OBJECTIVE: To develop and validate a scale for acanthosis nigricans (AN). RESEARCH DESIGN AND METHODS: Subjects were participants from the San Antonio Family Diabetes Study and the San Antonio Family Heart Study. A total of 406 subjects were independently examined for AN by at least two observers. Five locations were examined: the neck, axilla, elbows, knuckles, and knees. Interobserver concordance and kappa statistics were calculated to determine replicability of the scale. Comparisons of diabetes-related risk factors by AN score were also calculated. RESULTS: Only the neck had consistently high kappa statistics, and thus, other locations were excluded from further analyses. Elevated AN was strongly associated with elevated fasting insulin and BMI in both diabetic and nondiabetic subjects. Elevated AN was also strongly associated with elevated fasting glucose, systolic blood pressure, and diastolic blood pressure, and with decreased HDL in nondiabetic subjects. In diabetic subjects, elevated AN was associated with elevated total cholesterol. CONCLUSIONS: We have developed a scale for AN that is easy to use, has high interobserver reliability in Mexican Americans, and correlates well with fasting insulin and BMI. This scale will permit longitudinal and cross-sectional evaluation of AN and will permit the evaluation of AN as a trait in genetic studies. (+info)Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. (4/88)
Several gain-of-function mutations in a receptor tyrosine kinase, fibroblast growth factor receptor 3 (FGFR3), cause dwarfism in humans. Two particularly severe dwarfisms, thanatophoric dysplasia type II (TDII) and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), are associated with glutamic acid (E) and methionine (M) substitutions at the K650 residue in the kinase domain. TDII is lethal at birth, whereas most of the SADDAN patients survive the perinatal period. However, FGFR3 with the SADDAN mutation is more activated than FGFR3 with the TDII mutation in vitro. To find out whether the K650M mutation also causes the SADDAN phenotype, we introduced the corresponding point mutation (K644M) into the mouse Fgfr3 gene. Heterozygous mutant mice show a phenotype similar to human SADDAN, e.g. the majority of the SADDAN mice survive the perinatal period. This suggests that the survival of SADDAN patients is indeed attributed to the K650M mutation in FGFR3. The long bone abnormalities in SADDAN mice are milder than the TDII model. In addition, overgrowth of the cartilaginous tissues is observed in the rib cartilage, trachea and nasal septum. The FGF ligand at the low concentration differentially activates Map kinase in primary chondrocyte cultures from wild-type and SADDAN mice. Comparisons of the molecular bases of the phenotypic differences in SADDAN and TDII mice may increase our understanding of the factors that influence the severity in these two related skeletal dysplasias. (+info)HAIR-AN syndrome: a multisystem challenge. (5/88)
HAIR-AN syndrome is an acronym for an unusual multisystem disorder in women that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The precipitating abnormality is thought to be insulin resistance, with a secondary increase in insulin levels and subsequent overproduction of androgens in the ovaries. Long periods of hyperinsulinism and, some suspect, hyperandrogenism can result in the cutaneous manifestation of acanthosis nigricans. Patients are often concerned about the physical manifestations of this disorder, including virilization and acanthosis nigricans, and may be less aware of systemic problems. Physicians should assess women with these problems for an underlying endocrine abnormality. Although a treatment regimen for the HAIR-AN syndrome has not been established, antiandrogen therapy and weight loss are useful. (+info)Association of acanthosis nigricans with race and metabolic disturbances in obese women. (6/88)
Acanthosis nigricans (AN) has been recognized as a marker of insulin resistance and diabetes mellitus. We have compared frequency of race and metabolic disturbances in obese women with several degrees of AN (AN group, N = 190) to a group without AN (non-AN group, N = 61) from a mixed racial population. The groups were similar regarding age and body mass index. All patients (except the diabetic patients) underwent an oral glucose tolerance test (75 g). The racial distribution of this population was 35.1% white, 37.8% mulatto and 27.1% black and the frequency of AN was 62.5, 82.1 and 83.8%, respectively, higher in black versus white (P = 0.003) and mulatto versus white (P = 0.002) women. The frequencies of diabetes mellitus and impaired glucose tolerance were 5.8 and 12.6% in the AN group and 1.6 and 8.2% in the non-AN group, respectively (P>0.05). Fasting glucose, beta cell function determined by the homeostasis model of assessment (HOMA), fasting insulin and insulin area under the curve were similar for the AN and non-AN groups. A higher HOMA insulin resistance was observed in the AN group compared to the non-AN group (P = 0.02) and in the subgroup of highest degree of AN compared to those with other degrees. The mean lipid levels and the frequency of dyslipidemia were similar for the two groups. AN was strongly associated with the black or mulatto rather than the white race, even after taking into account the effect of age, body mass index and HOMA insulin resistance. (+info)Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. (7/88)
As dietary sources of gamma-linolenic acid [GLA; 18:3(n-6)], borage oil (BO; 24-25 g/100 g GLA) and evening primrose oil (PO; 8-10 g/100 g GLA) are efficacious in treating skin disorders. The triglycerol stereospecificity of these oils is distinct, with GLA being concentrated in the sn-2 position of BO and in the sn-3 position of PO. To determine whether the absolute level and/or the triglycerol stereospecificity of GLA in oils affect biological efficacy, epidermal hyperproliferation was induced in guinea pigs by a hydrogenated coconut oil (HCO) diet for 8 wk. Subsequently, guinea pigs were fed diets of PO, BO or a mixture of BO and safflower oil (SO) for 2 wk. The mixture of BO and SO (BS) diet had a similar level of GLA as PO but with sn-2 stereospecificity. As controls, two groups were fed SO and HCO for 10 wk. Epidermal hyperproliferation was reversed by all three oils in the order of BO > BS > PO. However, proliferation scores of group PO were higher than of the normal control group, SO. The accumulations of dihomo-gamma-linolenic acid [DGLA; 20:3(n-6)], an elongase product of GLA, into phospholipids and ceramides, of 15-hydroxyeicosatrienoic acid (15-HETrE), the potent antiproliferative metabolite of DGLA, and of ceramides, the major lipid maintaining epidermal barrier, in the epidermis of group BO were greater than of groups BS and PO. Group BS had higher levels of DGLA, 15-HETrE and ceramides than group PO. With primary dependence on absolute levels, our data demonstrate that the antiproliferative efficacy of GLA in the epidermis is preferably exerted from sn-2 stereospecificity of GLA in BO. (+info)An incomplete from of acanthosis nigricans. (8/88)
The authors report a variation of the clinical picture of acanthosis nigricans in two patients with carcinoma of the stomach. (+info)other hyperkeratosis: Acanthosis nigricans *Confluent and reticulated papillomatosis. *Callus. *Ichthyosis acquisita. * ...
... acanthosis nigricans; and Vagabond's disease. ...
... with acanthosis nigricans; 610549; INSR Diabetes mellitus, ketosis-prone; 612227; PAX4 Diabetes mellitus, neonatal, with ... CRLF1 Crouzon syndrome with acanthosis nigricans; 612247; FGFR3 Crouzon syndrome; 123500; FGFR2 Cryptorchidism, bilateral; ...
Feb 2007). "Acral acanthosis nigricans (acral acanthotic anomaly)". J Am Acad Dermatol. 56 (2): 349-50. doi:10.1016/j.jaad. ... In 1994 he devised the commonly-accepted classification for acanthosis nigricans. He has served as editor of the Acta ... In 1981 he first described acral acanthotic anomaly (acral acanthosis nigricans). In 1980 Edmund Klein, Schwartz and associates ... In 1981 he discovered and described acral acanthosis nigricans. ...
Steiner CE, Cintra ML, Marques-de-Faria AP (December 2002). "Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome)". ... List of cutaneous conditions Samdani AJ (October 2004). "Ectodermal dysplasia with acanthosis nigricans (Lelis' syndrome)". J ... with acanthosis nigricans. Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual ...
Malignant acanthosis nigricans may also become evident, many times with the sudden eruption of multiple seborrheic keratoses, ... Tsai, Yu-Ju; Tsai, Yi-Jeng; Chuan, Ming-Tuo; Hu, Shu-Ling (2004), "The Combination of Tripe Palms, Acanthosis Nigricans and ... Florid cutaneous papillomatosis, malignant acanthosis nigricans, and the sign of Leser-Trélat may be highlighted as part of a ... May 2000). "Florid cutaneous and mucosal papillomatosis with acanthosis nigricans revealing a primary lung cancer". J Eur Acad ...
Metabolic syndrome (Syndrome X) Acanthosis nigricans Modan, Michaela; Halkin H; Almog S; Lusky A; Eshkol A; Shefi M; Shitrit A ...
Patients with insulin resistance may display acanthosis nigricans. A few patients with homozygous mutations in the INSR gene ...
Obesity is also one such symptoms in some women, and is also marked in women affected by PCOS, hirsutism, acanthosis nigricans ... HAIR-AN syndrome consists of hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN). It is a rare ... "Case Report Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome". Azziz, Ricardo; Carmina, Enrico; Dewailly, ... "Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic ...
... acanthosis nigricans, and the polycystic ovary syndrome (type a insulin resistance)". The New England Journal of Medicine. 319 ... Acanthosis Nigricans, and the Polycystic Ovary Syndrome (Type A Insulin Resistance)". New England Journal of Medicine. 319 (23 ... "The Syndromes of Insulin Resistance and Acanthosis Nigricans". New England Journal of Medicine. 294 (14): 739-745. doi:10.1056/ ...
Features included fat loss, severe insulin resistance, fatty liver, acanthosis nigricans and diabetes. This not known with ... Other conditions associated with this condition include acanthosis nigricans, fatty liver, hypertriglyceridemia and polycystic ...
Herman, TE; Sargar, K; Siegel, MJ (Feb 2014). "Crouzono-dermo-skeletal syndrome, Crouzon syndrome with acanthosis nigricans ... People with Crouzonodermoskeletal syndrome have acanthosis nigricans, a skin condition characterized by thick, dark, velvety ... and Crouzon syndrome with acanthosis nigricans". Endocr Rev. 21 (1): 23-39. doi:10.1210/er.21.1.23. PMID 10696568. CS1 maint: ... during development and a skin condition called acanthosis nigricans. Some of the signs and symptoms of Crouzonodermoskeletal ...
Acanthosis nigricans-hyperpigmentation of intertriginous areas associated with insulin resistance. Melasma, also known as ...
Other complications include acanthosis nigricans, sexual dysfunction, and frequent infections. The development of type 2 ...
for example in those with polycystic ovarian syndrome or acanthosis nigricans). Non-challenge blood glucose tests involve ...
Obesity is associated with the incidence of stretch marks, acanthosis nigricans, lymphedema, cellulitis, hirsutism, and ...
Symptoms include growth abnormalities of the head, face and nails, along with the development of acanthosis nigricans. ... Prognathism and very thick fingernails as well as acanthosis nigricans were also described. Insulin-resistant diabetes ... A skin abnormality known as acanthosis nigricans, which involves a discoloration (hyperpigmentation) and "velvety" thickening ( ...
Acanthosis nigricans associated with malignancy (acanthosis nigricans type I) Acanthosis nigricans associated with obesity, ... acanthosis nigricans type III) Acral acanthosis nigricans (acral acanthotic anomaly) Acral dry gangrene Acromegaly Addison's ... acanthosis nigricans type II) Growth hormone deficiency Hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR ... Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory ...
other hyperkeratosis: Acanthosis nigricans *Confluent and reticulated papillomatosis. *Callus. *Ichthyosis acquisita. * ...
A condition of darkened hyperplasia of the skin, frequently of the axilla and groin, known as acanthosis nigricans, is ... "Oral acanthosis nigricans, tripe palms and sign of leser-trelat in a patient with gastric adenocarcinoma". International ...
Acanthosis Nigricans in non-insulin dependent diabetes mellitus, Specialist:, Vol. 11, No. 3, April-June 1995 14. Insulin ...
A condition of darkened hyperplasia of the skin, frequently of the axilla and groin, known as acanthosis nigricans, is ... Pentenero M, Carrozzo M, Pagano M, Gandolfo S; Carrozzo; Pagano; Gandolfo (2004). "Oral acanthosis nigricans, tripe palms and ...
... such as acanthosis nigricans in the axilla. Most people with primary Addison's disease have darkening (hyperpigmentation) of ...
"Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu ...
... acanthosis nigricans) are sometimes found on the hands and feet and in the groin. Additional signs and symptoms of Beare- ...
... acanthosis nigricans), sexual dysfunction, and frequent infections.[23] There is also an association between type 2 diabetes ...
"acanthosis nigricans" at Dorlands Medical Dictionary *^ a b c d e f g h i j Habif, Thomas P. (2009). Clinical dermatology (5th ... Malignant acanthosis nigricans refers to acanthosis nigricans occurring as a paraneoplastic syndrome associated with a cancer. ... For example, obesity-related acanthosis nigricans will improve with weight loss, and drug-induced acanthosis nigricans is ... acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms.[5][6] ...
Risk factors for acanthosis nigricans include: * Lymphoma * Oral contraceptives * Obesity ... ... Another name for Acanthosis Nigricans is Acanthosis Nigricans. ... Acanthosis Nigricans Risk Factors. Risk factors for acanthosis ... PubMed Acanthosis Nigricans References *Hermanns-Le T, Hermanns JF, Pierard GE. Juvenile acanthosis nigricans and insulin ... Continue to Acanthosis Nigricans Symptoms Last Updated: Feb 21, 2008 References Authors: Stephen J. Schueler, MD; John H. ...
What is acanthosis nigricans? Meaning of acanthosis nigricans medical term. What does acanthosis nigricans mean? ... Looking for online definition of acanthosis nigricans in the Medical Dictionary? acanthosis nigricans explanation free. ... Acanthosis nigricans: Acanthosis nigricans is a cosmetic condition strongly associated with insulin resistance in which there ... The patients were graded according to acanthosis nigricans severity on a 1-4 scale.. Acanthosis nigricans severity flags ...
Trata-men-tul trebuie îndreptat asupra afecţiunii care stă la baza apariţiei acanthosis nigricans. Deşi conduita terapeutică ... Revizuirea ac-tua-lă pune în evidenţă eficacitatea terapiilor actuale ale acanthosis nigricans. ... Acanthosis nigricans este de obicei asociat cu rezistenţa la insulină, diabetul zaharat, obezitatea, tumorile maligne, tul-bu- ... În cazul acanthosis nigricans indus medicamentos, stoparea agentului cauzal duce la remiterea acanthosis nigricans; ...
... , or AN, is a darkening and thickening of the skin that can be a sign of certain other medical conditions. ... What Is Acanthosis Nigricans?. If you have acanthosis nigricans (ah-kan-THO-sis NY-gruh-kans), youre probably concerned about ... What Causes Acanthosis Nigricans?. People who are overweight or obese are more likely to develop acanthosis nigricans, which ... Treatment for Acanthosis Nigricans. If your doctor finds that your acanthosis nigricans isnt connected to a more serious ...
eating a special diet can help reduce circulating insulin and may lead to some improvement of the acanthosis nigricans. other ... How is acanthosis nigricans treated?. ANSWER Eating a special diet can help reduce circulating insulin and may lead to some ... Acanthosis nigricans caused by a drug may go away once the medication is stopped. ... improvement of the acanthosis nigricans.. Other treatments to improve skin appearance include Retin-A, 20% urea, alpha ...
Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. ... Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. ...
Acanthosis nigrincans is hyperpigmentation and hyperkeratosis of the skin, which may be indicative of an underlying health ... http://www.dermnetnz.org/topics/acanthosis-nigricans/. *https://www.aad.org/public/diseases/color-problems/acanthosis-nigricans ... The aim of acanthosis nigricans treatment is to establish and manage the underlying cause of disease in an appropriate manner. ... For patients with acanthosis nigricans caused by an inherited genetic factor, the condition usually stabilizes or regresses ...
... medlineplus.gov/genetics/condition/crouzon-syndrome-with-acanthosis-nigricans/ Crouzon syndrome with acanthosis nigricans. ... Acanthosis nigricans is a skin condition characterized by thick, dark, velvety skin in body folds and creases, including the ... Crouzon syndrome with acanthosis nigricans is rare; this condition occurs in about 1 person per million. For unknown reasons, ... A mutation in the FGFR3 gene causes Crouzon syndrome with acanthosis nigricans. This gene provides instructions for making a ...
By 1909, acanthosis nigricans had been described in approximately 50 patients and was suspected to be associated wit... ... the first documented case of acanthosis nigricans was in 1889 in Germany as described by Unna and Pollitzer. ... Although Addison may have seen a case of acanthosis nigricans (AN) before 1885 and misdiagnosed it as Addison disease, ... Syndromic acanthosis nigricans. Syndromic acanthosis nigricans is the name given to acanthosis nigricans that is associated ...
Although there is no specific treatment of Acanthosis Nigricans, these skin areas may be lightened to fade these changes. Learn ... Acanthosis Nigricans is a skin condition in which the skin of the body creases and fold become dark, thick and velvety. It is ... Acanthosis nigricans - Wikipedia. Learn more about Acanthosis Nigricans.. *Acanthosis Nigricans. Learn what causes acanthosis ... Acanthosis Nigricans is a skin condition in which the skin of the body creases and fold become dark, thick and velvety. It is ...
... A. H. Dédjan, A. Chadli, S. El Aziz, and A. Farouqi ... R. L. Barbieri and K. J. Ryan, "Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common ...
... A. H. Dédjan, A. Chadli, S. El Aziz, and A. Farouqi ... The maternal antecedent of the metabolic syndrome present in the patient as well as the presence of acanthosis nigricans well ... Several etiologies are incriminated but the hyperandrogenism-insulin resistance-acanthosis nigricans syndrome is rare. ... R. L. Barbieri and K. J. Ryan, "Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common ...
Subdivisions of Acanthosis Nigricans. *Acanthosis Nigricans With Insulin Resistance Type A. *Acanthosis Nigricans With Insulin ... www.mayoclinic.com/health/acanthosis-nigricans/DS00653/DSECTION=5. Levine N, Baron J. Acanthosis Nigricans. emedicine. Last ... Acanthosis nigricans is a condition that may become apparent at any age. Many benign forms develop during childhood or puberty ... Acanthosis nigricans is most commonly found in people of African descent and some cases are genetically inherited as an ...
By 1909, acanthosis nigricans had been described in approximately 50 patients and was suspected to be associated wit... ... the first documented case of acanthosis nigricans was in 1889 in Germany as described by Unna and Pollitzer. ... Although Addison may have seen a case of acanthosis nigricans (AN) before 1885 and misdiagnosed it as Addison disease, ... Acanthosis Nigricans) and Acanthosis Nigricans What to Read Next on Medscape. Related Conditions and Diseases. * Acanthosis ...
Aquired Acanthosis Nigricans. The acanthosis nigricans may also have a secondary form and may occur due to an excess of pigment ... Genetic Acanthosis Nigricans. If the acanthosis nigricans is genetic, it will most likely affect dog breeds such as the ... Acanthosis Nigricans Detection. The diagnosis of acanthosis nigricans will be done through evaluating the dogs history and by ... The secondary acanthosis nigricans may be treated while primary acanthosis nigricans may be controlled through medication. ...
... acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms. Acanthosis nigricans may present ... This form of acanthosis nigricans is more likely to involve mucous membranes (25-50% of cases) Malignant acanthosis nigricans ... Acanthosis nigricans maligna may resolve if the causative tumor is successfully removed. Acanthosis nigricans is likely to ... Malignant acanthosis nigricans refers to acanthosis nigricans occurring as a paraneoplastic syndrome associated with a cancer. ...
Microscopic acanthosis nigricans in type 2 diabetes.. McManus RM1, Gottschalk R, Alanen K, Shum DT, Grundy P. ... Microscopic acanthosis nigricans was found in similar numbers of people with DM when compared with C. Fasting insulin levels ... Acanthosis nigricans (AN) has been associated with insulin resistance. Individuals with type 2 diabetes are insulin-resistant ... Height, weight, waist/hip measures, and a clinical survey for acanthosis were recorded. A 2-mm skin biopsy from midaxilla of ...
... Acanthosis nigricans (ay-can-THO-sis NYG-ruh-cans) is a condition ... Acanthosis nigricans is more common in people who have high levels of the hormone insulin in their blood due to insulin ... In acanthosis nigricans, thick, dark, and sometimes streaky patches appear on the skin. The patches are harmless and arent ... However, acanthosis nigricans also can be hereditary and occur in kids and teens who are otherwise healthy. ...
Acanthosis nigricans is staged according to the scoring system below: Absent (0): Not detectable on close inspection Present (1 ... How is acanthosis nigricans staged in women with polycystic ovarian syndrome (PCOS)?) and How is acanthosis nigricans staged in ... How is acanthosis nigricans staged in women with polycystic ovarian syndrome (PCOS)?. Updated: Sep 19, 2019 ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Most patients with acanthosis nigricans have a higher insulin level than those of the same weight without acanthosis nigricans ... Rarely acanthosis nigricans is associated with a tumor, most commonly of the stomach or gut. In these cases acanthosis can bee ... Acanthosis nigricans is a disorder that may begin at any age. It causes velvety, light-brown-to-black, markings usually on the ... Acanthosis nigricans is most often associated with obesity.. Eating too much of the wrong foods, especially starches and sugars ...
4B). Like the proband, her half sister presented with weight gain (BMI SDS +3.5) and acanthosis nigricans at the age of 9. She ... Her mother, a 41-year-old woman, was obese (BMI SDS +3.1) but had no acanthosis nigricans. Following an oral glucose load she ... 4A). After puberty and a period of weight loss (age 23 years; BMI SDS +1.4), her acanthosis nigricans resolved. Although her ... 2A) in a female patient with acanthosis nigricans. The mutation is predicted to truncate the protein at amino acid 363 (R363X ...
2015). Acanthosis nigricans. Retrieved from http://www.mayoclinic.org/diseases-conditions/acanthosis-nigricans/basics/ ... Acanthosis nigricans is a skin condition in which areas of the skin is of a dark and velvety discoloration, often seen in the ... Within those affected by SADDAN, acanthosis nigricans develops early on, usually in infancy or early childhood. The mutated ... Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), is a very rare genetic disorder. This ...
Acanthosis nigricans. J Am Acad Dermatol. 1994;31:1-19. [ Links ]. 17. Curth HO. Classification of acanthosis nigricans. Int J ... 1.2 Acanthosis Nigricans. Acanthosis nigricans (AN) was initially proposed by Unna and then published by Pollitzer and Janovsky ... syndromic and pseudo-acanthosis nigricans (Table 1). 17 The term pseudo-acanthosis nigricans was reserved for cases in which ... Association of acanthosis nigricans with race and metabolic disturbances in obese women. Braz J Med Biol Res. 2002;35:59-64. [ ...
Insulin resistanceEndocrineConditionCause acanthosis nigricansRisk of developing acanthosiCase of acanthosis nigricansForms of acanthosis nigricansPresence of acanthosis nigricansEpidermalPathogenesis of acanthosis nigricansFamilialPseudo-acanthosis nigricansDevelop acanthosis nigricansCrouzonChildren with acanthosisSyndromeLesionsHereditaryHyperkeratosisOverweightHyperpigmentationDrug-induced Acanthosis NigricansSADDANDiagnosis of acanthosis nigricansCutaneousAcromegalyLead to acanthosis nigricansSign of acanthosis nigricansCases of acanthosis nigricansFactors of acanthosis nigricansSymptom of Acanthosis nigricansSuffer from acanthosis nigricansPatients with acanthosis nigricansPrevalence of acanthosis nigricansAssociation of acanthosis nigricansInsulin in the bOccursDiabetes mellitusHyperinsulinemiaAssociated with insulinTreat acanthosis nigricansNevoid acanthosis nigricansDevelops acanthosis nigricansSecondary acanthosis nigricansTreatment for acanthosis
- In young persons, acanthosis nigricans is a visible marker which strongly suggests insulin resistance. (wikipedia.org)
- Benign This may include obesity-related, hereditary, and endocrine forms of acanthosis nigricans. (wikipedia.org)
- Acanthosis nigricans este de obicei asociat cu rezistenţa la insulină, diabetul zaharat, obezitatea, tumorile maligne, tul-bu-rările endocrine şi cu reacţiile medicamentoase. (medichub.ro)
- Acanthosis nigricans poate să apară ca manifestare a unei boli sistemice, de obicei asociată cu rezistenţa la insulină, diabetul zaharat, obezitatea, malignitatea internă, tulburările endocrine şi reacţiile medicamentoase (3) . (medichub.ro)
- The treatment should be centralized on the underlying condition of acanthosis nigricans. (medichub.ro)
- Certain medicines - for example, birth control pills or hormone treatments - also can cause acanthosis nigricans. (kidshealth.org)
- Elevated levels of insulin in most cases probably cause acanthosis nigricans. (aocd.org)
- High-dose niacin, birth control pills, prednisone and other corticosteroids may cause acanthosis nigricans. (fsetyt.com)
- Using oral contraceptives for long can cause acanthosis nigricans. (diseasespictures.com)
- Additionally, people with certain cancers -- including lymphoma and those of the gastrointestinal or genitourinary tracts -- are at risk of developing acanthosis nigricans. (diabetesmonitor.com)
- Although Addison may have seen a case of acanthosis nigricans (AN) before 1885 and misdiagnosed it as Addison disease , the first documented case of acanthosis nigricans was in 1889 in Germany as described by Unna and Pollitzer. (medscape.com)
- Cheng E, Roy DB, Magro CM. A case of acanthosis nigricans coexisting with mycosis fungoides. (medscape.com)
- Cancer associated with acanthosis nigricans: a review of the literature and report of a case of acanthosis nigricans with cancer of the breast. (bmj.com)
- Familial and syndromic forms of acanthosis nigricans have been identified. (medscape.com)
- Benign This may include obesity-related, hereditary, and endocrine forms of acanthosis nigricans. (wikipedia.org)
- A factor called transforming growth alpha has been cited as the most likely factor to cause the occurrence of cancerous forms of acanthosis nigricans. (allhealthsite.com)
- There are 5 forms of acanthosis nigricans. (medicalrealm.net)
- Insulin resistance has been associated with presence of acanthosis nigricans and acrochordons. (scielo.br)
- Thus, the presence of acanthosis nigricans is a strong predictor of future diabetes. (khune.org)
- To determine whether the presence of acanthosis nigricans in obese children is related with insulin resistance. (biomedcentral.com)
- Acanthosis nigricans most likely is caused by factors that stimulate epidermal keratinocyte and dermal fibroblast proliferation. (medscape.com)
- In the benign form of acanthosis nigricans, the factor is probably insulin or an insulinlike growth factor (IGF) that incites the epidermal cell propagation. (medscape.com)
- TGF-alpha and epidermal growth factor have both been found in gastric adenocarcinoma cells, and EGFR expression has been identified in skin cells within acanthosis nigricans lesions. (medscape.com)
- Histopathologically, all forms of AN demonstrate epidermal hyperkeratosis, papillomatosis and minimal to mild acanthosis. (oncologynurseadvisor.com)
- Rather than pigment-producing cells, epidermal papillomatosis and acanthosis are responsible for the hyperpigmentation observed in AN (Figure 10A and Figure 10B). (oncologynurseadvisor.com)
- Unilateral epidermal nevus resembling acanthosis nigricans. (bmj.com)
- The acanthosis nigricans form of epidermal nevus. (bmj.com)
- Eight cases of the acanthosis nigricans form of epidermal nevus have been described in literature. (ru.nl)
- Histopathological investigation showed aspects of both acanthosis nigricans and epidermal nevus. (ru.nl)
- As previous cases show a clear association with internal diseases, repetitive screening for internal diseases and syndromes is suggested in the case of the acanthosis nigricans form of epidermal nevus. (ru.nl)
- The pathophysiological process behind acanthosis nigricans appears to be related to the proliferation of fibroblasts and the enhanced stimulation of epidermal keratinocytes. (statpearls.com)
- Acanthosis nigricans skin patches occur when epidermal skin cells begin to reproduce rapidly. (khune.org)
- The FGFR3 gene mutations found in epidermal nevi also occur in people with another skin abnormality called seborrheic keratosis and in people with skeletal disorders known as thanatophoric dysplasia, Crouzon syndrome with acanthosis nigricans, and SADDAN (each described in another section on this page). (nih.gov)
- The pathogenesis of acanthosis nigricans is poorly understood, and likely to relate to an interplay of factors, including insulin-mediated activation of ILGF receptors on keratinocytes, and increased growth factor levels. (wikipedia.org)
- The exact pathogenesis of acanthosis nigricans is not clear, although there are several risk factors that are associated with the disorder. (news-medical.net)
- The pathogenesis of acanthosis nigricans is likely related to growth factor levels and insulin-mediated activation of insulin-like growth factor (IGF) on keratinocytes and increased growth factor levels. (statpearls.com)
- It typically occurs in individuals younger than age 40, may be genetically inherited, and is associated with obesity or endocrinopathies, such as hypothyroidism, acromegaly, polycystic ovary disease, insulin-resistant diabetes, or Cushing's disease Familial acanthosis may arise as a result of an autosomal dominant trait, presenting at birth or developing during childhood. (wikipedia.org)
- Familial cases of acanthosis nigricans with no other syndromic findings have also been linked to FGFR mutations. (medscape.com)
- Familial acanthosis may arise as a result of an autosomal dominant trait, presenting at birth or developing during childhood. (wikipedia.org)
- Familial acanthosis nigricans due to K650T FGFR3 mutation. (medscape.com)
- Successful symptomatic tazarotene treatment of juvenile acanthosis nigricans of the familial obesity-associated type in insulin resistance]. (nih.gov)
- Following a thorough endocrinological examination and because the patient's obese mother showed similar skin lesions, the disease was subclassified as a familial obesity-associated type of acanthosis nigricans associated with insulin resistance. (nih.gov)
- This is likely because of insulin resistance, and more likely to occur in darker-skinned persons.This is also known as "Pseudo-Acanthosis Nigricans", or "Type 3 Acanthosis Nigricans".Also associated with acromegaly. (medvin2u.net)
- Type 3 pseudo acanthosis nigricans is due to obesity, metabolic syndrome and darker pigmentation. (medicalrealm.net)
- People who are overweight or obese are more likely to develop acanthosis nigricans, which often lessens or goes away with weight loss. (kidshealth.org)
- Almost 75% of kids with type 2 diabetes develop acanthosis nigricans, according to the American Diabetes Association. (kidshealth.org)
- Children who develop acanthosis nigricans are at a higher risk of developing type 2 diabetes later in life. (khune.org)
- Children who develop acanthosis nigricans have increased chances of getting diabetes type two. (homenaturalcures.com)
- Crouzon syndrome with acanthosis nigricans is a disorder characterized by the premature joining of certain bones of the skull (craniosynostosis) during development and a skin condition called acanthosis nigricans. (medlineplus.gov)
- The signs and symptoms of Crouzon syndrome with acanthosis nigricans overlap with those of a similar condition called Crouzon syndrome. (medlineplus.gov)
- People with Crouzon syndrome or Crouzon syndrome with acanthosis nigricans usually have normal intelligence. (medlineplus.gov)
- Crouzon syndrome with acanthosis nigricans is distinguished from Crouzon syndrome by several features, including skin abnormalities. (medlineplus.gov)
- Less common features of Crouzon syndrome with acanthosis nigricans include subtle changes in the bones of the spine (vertebrae), abnormalities of the finger bones, and noncancerous growths in the jaw called cementomas. (medlineplus.gov)
- A mutation in the FGFR3 gene causes Crouzon syndrome with acanthosis nigricans. (medlineplus.gov)
- These changes lead to the features of Crouzon syndrome with acanthosis nigricans. (medlineplus.gov)
- Arnaud-López L, Fragoso R, Mantilla-Capacho J, Barros-Núñez P. Crouzon with acanthosis nigricans. (medlineplus.gov)
- Sharda S, Panigrahi I, Gupta K, Singhi S, Kumar R. A newborn with acanthosis nigricans: can it be Crouzon syndrome with acanthosis nigricans? (medscape.com)
- Acanthosis nigricans in children and Crouzon syndrome]. (medscape.com)
- A single FGFR3 gene mutation has been identified in people with Crouzon syndrome with acanthosis nigricans. (nih.gov)
- The genetic change that causes Crouzon syndrome with acanthosis nigricans replaces the amino acid alanine with the amino acid glutamic acid at position 391 of the FGFR3 protein (written as Ala391Glu or A391E). (nih.gov)
- The resulting overactivity of the FGFR3 protein disrupts the normal growth of the skull bones and skin, leading to the features of Crouzon syndrome with acanthosis nigricans. (nih.gov)
- Metabolic syndrome in fifth grade children with acanthosis nigricans: results from the CARDIAC project. (medscape.com)
- Assess the prevalence of abnormal glucose metabolism among Hispanic parents of children with acanthosis nigricans (AN). (core.ac.uk)
- In this study the prevalence of impaired glucose (carbohydrate) tolerance in lean children with a family history of diabetes and obese children with acanthosis nigricans with or without a family history of diabetes mellitus will be studied. (clinicaltrials.gov)
- We found insulin resistance in 84.4% of obese children with acanthosis nigricans. (biomedcentral.com)
- Children with acanthosis nigricans are more likely have insulin resistance. (biomedcentral.com)
- Insulin-resistance syndromes include those with mutations in the insulin receptors (ie, leprechaunism, Rabson-Mendenhall syndrome), peroxisome proliferator-activated receptor gamma (ie, type 1 diabetes with acanthosis nigricans and hypertension), 1-acylglycerol-3-phosphate O-acyl transferase-2 or seipin (Berardinelli-Seip syndrome), lamin A/C (Dunnigan syndrome), and Alstrom syndrome gene. (medscape.com)
- Several etiologies are incriminated but the hyperandrogenism-insulin resistance-acanthosis nigricans syndrome is rare. (hindawi.com)
- The hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR-AN syndrome) is also incriminated [ 4 , 5 ]. (hindawi.com)
- Krawczyk M, Mykala-Ciesla J, Kolodziej-Jaskula A. Acanthosis nigricans as a paraneoplastic syndrome. (medscape.com)
- How is acanthosis nigricans staged in women with polycystic ovarian syndrome (PCOS)? (medscape.com)
- Syndromic - Type A refers to patients with HAIR-AN (hyperandrogenism, insulin resistance, and acanthosis nigricans) syndrome and acromegaly. (visualdx.com)
- What is the role of hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN) syndrome in the etiology of androgen excess? (medscape.com)
- HAIR-AN syndrome is a subset of women with PCOS who present with hyperandrogenism, insulin resistance, acanthosis nigricans, and obesity in the absence of insulin receptor defect. (medscape.com)
- Patients with gastric cancer occasionally present with paraneoplastic syndromes, such as acanthosis nigricans, membranous glomerulonephritis, microangiographic hemolytic anemia, arterial and venous thrombi (Trousseau syndrome), seborrheic dermatitis (Leser-Trélat sign), and dermatomyositis. (gastrointestinalatlas.com)
- Polycystic ovarian syndrome (PCOS) is associated with Acanthosis nigricans. (statpearls.com)
- Benign acanthosis nigricans may be associated with obesity, polycystic ovary syndrome (PCOS), diabetes mellitus, adrenal insufficiency and other insulin-resistant conditions. (healthjade.com)
- Type 2 benign acanthosis nigricans is associated with hyperandrogenic states, Cushing disease, acromegaly, insulin resistant type II diabetes mellitus, hypogonadal syndrome, hypothyroidism and Addison disease. (medicalrealm.net)
- The common differential diagnosis of acanthosis nigricans may include pityriasis versicolor, ingestion of nicotinic acid, hyperkeratosis retention, X linked ichthyosis and Gougerot Carteaud Syndrome / reticulated papillomatosis. (medicalrealm.net)
- [ 6 , 7 ] Agents such as palifermin (recombinant keratinocyte growth factor used to decrease mucositis with chemotherapy and stem cell transplantation) have reportedly produced transient but dramatic acanthosis nigricans-like lesions, presumably due to activation of the FGFR. (medscape.com)
- Hence we concluded that these lesions were unlikely to be acanthosis nigricans and continued management for type 1 diabetes. (endocrine-abstracts.org)
- Acanthosis nigricans presents as a smooth, thickened, and dark appearance to the skin in body fold areas, most often in the axilla and around the neck If extensive, it may lead to a striking appearance, with thickening of the palms and soles and oral lesions of hyperkeratosis. (gastrointestinalatlas.com)
- Discontinuation of the drug leads to improvement or even disappearance of the acanthosis nigricans lesions. (healthjade.com)
- Acanthosis nigricans may also occurs with hyperkeratosis of the soles and palms, "tripe hands" or accentuation of the papillary marking.Lesions may also present on the groins, antecubital fossae, umbilicus, submammary area and knuckles. (medicalrealm.net)
- Secondary acanthosis nigricans refers to clinical skin reaction pattern that is characterized by visually similar lesions and is seen in a variety of breeds. (blogspot.com)
- In secondary acanthosis nigricans, the lesions will spontaneously resolve after identification and correction of the underlying cause. (blogspot.com)
- However, acanthosis nigricans also can be hereditary and occur in kids and teens who are otherwise healthy. (rchsd.org)
- Other than that, acanthosis nigricans may also be a hereditary condition. (allhealthsite.com)
- Type 1 acanthosis nigricans is known as type 1 hereditary benign which has no relation with the endocrine disorder. (medicalrealm.net)
- Acanthosis nigrincans is hyperpigmentation and hyperkeratosis of the skin, which may be indicative of an underlying health condition. (news-medical.net)
- Histologic examination reveals hyperkeratosis, papillomatosis, with minimal or no acanthosis or hyperpigmentation. (medscape.com)
- Mucosal acanthosis nigricans reveals epithelial hyperkeratosis and papillomatosis along with parakeratosis. (medscape.com)
- Acanthosis Nigricans, which is a skin condition characterized by darkening and thickening of skin caused by papillomatosis and hyperkeratosis has been reported to be linked to insulin resistance and is thought to be a major factors in type 2 diabetes mellitus. (biomedcentral.com)
- For many, getting their diabetes and weight (if they are overweight) under control goes a long way toward lessening the visibility of acanthosis nigricans. (kidshealth.org)
- When acanthosis nigricans develops in people who are not overweight, a medical work-up should be done. (aocd.org)
- Acanthosis nigricans: a common finding in overweight youth. (bmj.com)
- Acanthosis nigricans is a disorder that may begin at any age and usually being of overweight. (lowcarber.org)
- Acanthosis nigricans is most often associated with being overweight. (lowcarber.org)
- Acanthosis nigricans usually strikes people who are very overweight. (diabetes.org)
- The main outcomes were the prevalence of acanthosis nigricans, type 2 diabetes risk factors (ethnicity, family history of type 2 diabetes, hypertension, overweight/obesity), type 2 diabetes, and the relationships among these. (unm.edu)
- Acanthosis nigricans (AN) is characterized by increased coloration or pigmentation (hyperpigmentation) and abnormal thickening of the skin. (rarediseases.org)
- Like AN, hypertrophic seborrheic keratoses may also demonstrate papillomatosis and acanthosis histologically, although unlike AN, hyperpigmentation is rare and horn cysts may also be present. (oncologynurseadvisor.com)
- Acanthosis nigricans is a skin condition in which discoloration and hyperpigmentation of the skin occurs, with dark skin around neck, often called black neck diabetes since it commonly occurs in diabetics. (medindia.net)
- Type 4 drug induced acanthosis nigricans due to high dose of nicotinic acid, oral contraceptive pills, diethylstilbestrol, growth hormone therapy and stilbestrol in young man. (medicalrealm.net)
- Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), is a very rare genetic disorder. (wikipedia.org)
- Within those affected by SADDAN, acanthosis nigricans develops early on, usually in infancy or early childhood. (wikipedia.org)
- The diagnosis of acanthosis nigricans will be done through evaluating the dog's history and by performing a biopsy of the skin. (vetinfo.com)
- Diagnosis of acanthosis nigricans is confirmed by a dermatologist. (biomedcentral.com)
- Acanthosis nigricans is a form of cutaneous marker which is mostly associated with malignancy, diabetes ( endocrine disorder ) and drug side effects. (medicalrealm.net)
- The cutaneous changes of acanthosis nigricans perform react to decreased blood insulin levels. (theestheticclinic.com)
- Acanthosis nigricans typically occurs in individuals younger than the age of 40 years and is associated with obesity, hypothyroidism, acromegaly, polycystic ovary disease, insulin-resistant diabetes, Cushing, and Addison diseases. (statpearls.com)
- A diet high in starches, carbohydrates and sugars might lead to acanthosis nigricans. (diabetesmonitor.com)
- There are some kinds of supplements and drugs that can lead to acanthosis nigricans such as birth control pills, prednisone, high - dose niacin and other types of corticosteroids. (homenaturalcures.com)
- The only sign of Acanthosis Nigricans is the dark skin changes . (hubpages.com)
- The majority of cases of acanthosis nigricans are associated with obesity and otherwise idiopathic. (wikipedia.org)
- In addition, other causative factors of acanthosis nigricans are friction and perspiration as evidenced by its dominance in areas of the body where there is presence of folds. (allhealthsite.com)
- You may notice high levels of insulin which is known to be one of the triggering factors of acanthosis nigricans. (homeodoctor.co.in)
- Typical skin changes are the only symptom of Acanthosis nigricans. (diseasespictures.com)
- Dark underarms are often a symptom of acanthosis nigricans. (medicalnewstoday.com)
- People with dark skin of any age are the most liable to suffer from Acanthosis Nigricans. (hubpages.com)
- People who suffer from acanthosis nigricans are becoming resistant to insulin. (homenaturalcures.com)
- If you suffer from acanthosis nigricans, then you have increased chances of getting diabetes type 2. (homenaturalcures.com)
- In some cases, particularly for patients with acanthosis nigricans associated with obesity, diet lifestyle changes may be sufficient to address the problem. (news-medical.net)
- For patients with acanthosis nigricans caused by an inherited genetic factor, the condition usually stabilizes or regresses spontaneously without treatment. (news-medical.net)
- Most patients with acanthosis nigricans have a higher insulin level than those of the same weight without acanthosis nigricans. (aocd.org)
- CONCLUSIONS: Patients with acanthosis nigricans are likely to have multiple risk factors for type 2 diabetes. (unm.edu)
- To determine the prevalence of acanthosis nigricans (AN) and other diabetes risk factors in urban school health clinics. (ebscohost.com)
- A study of the association of acanthosis nigricans with subclinical atherosclerosis. (diseaseinfosearch.org)
- The purpose of this study was to determine the association of acanthosis nigricans with type 2 diabetes risk factors and disease in young persons. (unm.edu)
- WebMD suggests that eating too much of the wrong food can also trigger acanthosis nigricans, as the condition is sometimes associated with having too much insulin in the blood. (diabetesmonitor.com)
- Additionally, following a special diet to help reduce the amount of insulin in the blood can also help acanthosis nigricans improve. (diabetesmonitor.com)
- The secondary acanthosis nigricans typically occurs later in the dog's life and not before the age of 1, as primary acanthosis nigricans does. (vetinfo.com)
- Acanthosis nigricans also has no specific age at which it occurs. (allhealthsite.com)
- Suspicion for malignancy-associated acantosis nigricans should arise when it occurs when resent onset in a non-obese patient who does not have diabetes. (gastrointestinalatlas.com)
- In general, Acanthosis Nigricans is associated with the conditions in which there is increased level of insulin, a condition called insulin resistance , as in Diabetes Mellitus Type II or obesity. (hubpages.com)
- Acanthosis nigricans among women with gestational diabetes mellitus and risk of adverse pregnancy outcomes. (medscape.com)
- This study aimed to evaluate the role of acanthosis nigricans (AN) as a marker of Type 2 Diabetes Mellitus (T2DM) by studying its prevalence and relationship with age, ethnicity, anthropometry and other risk factors for T2DM in the Trinidadian population. (altmetric.com)
- PURPOSE: Evidence shows acanthosis nigricans is often associated with hyperinsulinemia and may indicate increased risk of type 2 diabetes mellitus. (unm.edu)
- Therefore, we need to identify acanthosis nigricans in obese children for the possibility of diabetes mellitus type 2 so early intervention can be done. (biomedcentral.com)
- A female presenting at age 11 years with acanthosis nigricans and extreme postprandial hyperinsulinemia was heterozygous for a premature stop mutation (R363X) in TBC1D4 . (pnas.org)
- Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. (scienceopen.com)
- This study examined the prevalence of both basal and glucose-stimulated hyperinsulinemia and acanthosis nigricans (AN) as well as the relationship between insulin and androgen levels in hyperandrogenic women. (scienceopen.com)
- Acanthosis nigricans (AN) has been associated with insulin resistance. (nih.gov)
- Maintaining a healthy weight by staying physically active and eating well can help prevent or treat acanthosis nigricans in some cases. (kidshealth.org)
- Unilateral nevoid acanthosis nigricans treated with CO2 laser. (diseaseinfosearch.org)
- Also called as nevoid Acanthosis nigricans. (statpearls.com)
- Who develops acanthosis nigricans? (diabetesmonitor.com)
- In a patient known to have had an abdominal adenocarcinoma who then develops acanthosis nigricans, a vigorous search for recurrence or metastatic disease should be undertaken. (gastrointestinalatlas.com)
- The secondary acanthosis nigricans may be treated while primary acanthosis nigricans may be controlled through medication. (vetinfo.com)
- If the vet suspects secondary acanthosis nigricans, he will perform a number of tests to determine the underlying cause. (vetinfo.com)
- For the secondary acanthosis nigricans there are several treatment options. (vetinfo.com)
- There is no specific treatment for Acanthosis Nigricans. (hubpages.com)
- There is no satisfactory dermatological or cosmetic treatment for acanthosis nigricans, and biopsy of the skin is neither helpful. (gastrointestinalatlas.com)
- Treatment for acanthosis nigricans is largely focused on addressing the underlying causative factors. (homeodoctor.co.in)