Acantholysis: Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.Pemphigus: Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.Desmoglein 3: A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS VULGARIS.Desmoglein 1: A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.Desmosomes: A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Darier Disease: An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.Pemphigus, Benign Familial: An autosomal dominantly inherited skin disorder characterized by recurrent eruptions of vesicles and BULLAE mainly on the neck, axillae, and groin. Mutations in the ATP2C1 gene (encoding the secretory pathway Ca2++/Mn2++ ATPase 1 (SPCA1)) cause this disease. It is clinically and histologically similar to DARIER DISEASE - both have abnormal, unstable DESMOSOMES between KERATINOCYTES and defective CALCIUM-TRANSPORTING ATPASES. It is unrelated to PEMPHIGUS VULGARIS though it closely resembles that disease.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Blister: Visible accumulations of fluid within or beneath the epidermis.Desmogleins: A group of desmosomal cadherins with cytoplasmic tails that resemble those of classical CADHERINS.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Dictionaries, MedicalPubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.District of Columbia: A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Skin Diseases, Vesiculobullous: Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)Fluocinonide: A topical glucocorticoid used in the treatment of ECZEMA.Scalp DermatosesSneddon Syndrome: A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of livedo reticularis, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)Hand DermatosesFacial DermatosesNeuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Mobile Applications: Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.Computers, Handheld: A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.Skin DiseasesRepetition Priming: A type of procedural memory manifested as a change in the ability to identify an item as a result of a previous encounter with the item or stimuli.Impetigo: A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.Chickenpox: A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)Gram-Positive Bacterial Infections: Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.Gram-Positive Bacteria: Bacteria which retain the crystal violet stain when treated by Gram's method.Micrococcus luteus: A species of gram-positive, spherical bacteria whose organisms occur in tetrads and in irregular clusters of tetrads. The primary habitat is mammalian skin.Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.Exfoliatins: Protein exotoxins from Staphylococcus aureus, phage type II, which cause epidermal necrolysis. They are proteins with a molecular weight of 26,000 to 32,000. They cause a condition variously called scaled skin, Lyell or Ritter syndrome, epidermal exfoliative disease, toxic epidermal necrolysis, etc.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.

The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic. (1/42)

Pemphigus vulgaris and pemphigus foliaceus are two closely related, but clinically and histologically distinct, autoimmune skin diseases. The autoantigens for pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively. The anti-desmoglein 1 antibodies in pemphigus foliaceus and anti-desmoglein 3 antibodies in pemphigus vulgaris are pathogenic as determined by immunoglobulin G passive transfer animal models. More than 50% of pemphigus vulgaris sera also contain anti-desmoglein 1 autoantibodies; however, the pathogenicity of the anti-desmoglein 1 autoantibodies in pemphigus vulgaris remains unknown. In this study, we used soluble recombinant extracellular domains of desmoglein 1 and desmoglein 3 to obtain affinity-purified anti-desmoglein 1 and anti-desmoglein 3 autoantibodies from pemphigus vulgaris sera and examined the pathogenicity of each fraction separately using the passive transfer mouse model. By immunoprecipitation, the purified anti-desmoglein 1 and anti-desmoglein 3 showed no cross-reactivity. The anti-desmoglein 1 autoantibodies in pemphigus vulgaris induced typical pemphigus foliaceus lesions in neonatal mice, whereas the anti-desmoglein 3 fraction induced pemphigus vulgaris-like lesions. In addition, the pathogenic anti-desmoglein 1 and anti-desmoglein 3 autoantibodies in pemphigus vulgaris had predominant IgG4 subclass specificity. These findings suggest that the anti-desmoglein 1 antibodies in pemphigus vulgaris are pathogenic.  (+info)

Immune modulation in pemphigus vulgaris: role of CD28 and IL-10. (2/42)

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease characterized by Abs to the desmosomal cadherin desmoglein-3. Although the autoantibodies have been shown to be pathogenic, the role of the cellular immune system in the pathology of pemphigus-induced acantholysis is unclear. To further delineate the potential role of T cell-signaling pathways in the pathogenesis of PV, we performed passive transfer experiments with PV IgG in gene-targeted mutant mice. Our results demonstrated that CD28-deficient mice (lacking a costimulatory signal for T cell activation) are 5-fold more sensitive to the development of PV than wild-type mice. To evaluate whether the higher incidence of disease was due to an impairment in intercellular adhesion of keratinocytes, we performed an in vitro acantholysis, using CD28-/- mice keratinocytes. No alteration in in vitro adhesion was detected in CD28-/--type keratinocytes. Because the CD28 molecule plays a pivotal role in the induction of Th2 cytokines, we examined the levels of a prototypic Th2 cytokine (IL-10) in CD28-/- mice. Lower levels of IL-10 mRNA were found in lesions from CD28-/- mice. To determine whether pemphigus susceptibility in CD28-/- was related to IL-10 deficiency, we performed passive transfer experiments in IL-10-/- mice that demonstrated increased blisters compared with controls. To confirm that IL-10 is involved in the pathogenesis, rIL-10 was given with PV IgG. IL-10 significantly suppressed the disease activity. These data suggest a potential role of IL-10 in PV.  (+info)

In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. (3/42)

Keratinocyte-derived cytokines have been implicated in the pathogenesis of a number of skin diseases. In this study we examined the possible role of keratinocyte-derived cytokines in the development of acantholysis in pemphigus vulgaris. Nineteen patients with pemphigus vulgaris, demonstrating the characteristic clinical, pathologic, and immunopathologic findings were studied. In situ immunolabeling demonstrated the presence of two cytokines interleukin-1alpha and tumor necrosis factor-alpha, in lesional and perilesional areas. Results were confirmed by reverse transcriptase-polymerase chain reaction, demonstrating overexpression of both cytokines in vivo. To study the role of these cytokines in the pathogenesis of pemphigus vulgaris both in vitro and in vivo studies were performed. The results of the in vitro study demonstrated that pemphigus vulgaris IgG induced interleukin-1alpha and tumor necrosis factor-alpha mRNA in the skin. The potential pathogenic role of these mediators was demonstrated by a blocking study using antibodies against human interleukin-1alpha and tumor necrosis factor-alpha in keratinocytes cultures. A combination of anti-interleukin-1alpha and anti-tumor necrosis factor-alpha antibodies inhibited in vitro pemphigus vulgaris IgG induced acantholysis. To confirm the role of interleukin-1 and tumor necrosis factor-alpha in pemphigus, we utilized passive transfer studies using interleukin-1 deficient mice (ICE-/-, interleukin-1beta-/-) and tumor necrosis factor-alpha receptor deficient mice (TNFR1R2-/-). Both groups demonstrated a decreased susceptibility to the passive transfer of pemphigus. Our data support the role of cytokines interleukin-1 and tumor necrosis factor-alpha in the pathogenesis of pemphigus vulgaris.  (+info)

Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. (4/42)

Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. It was assumed that PV is caused by anti-desmoglein (Dsg) 3 autoimmunity because absorption of PV sera with a chimeric baculoprotein containing the Dsg 3 and IgG1 portions, rDsg3-Ig-His, eliminated disease-causing antibodies. In this study we demonstrate that rDsg3-Ig-His adsorbs out autoantibodies to different keratinocyte antigens, including a non-Dsg 3 130-kd polypeptide. Because the pool of disease-causing PV IgGs contains antibodies against the keratinocyte acetylcholine receptor (AChR), we sought to identify the targeted receptor(s). Preincubation of monkey esophagus with PV antibodies blocked specific staining of the keratinocyte cell membrane with rabbit monoepitopic antibody to alpha9 AChR, indicating that this first of its kind AChR with dual, muscarinic and nicotinic pharmacology is targeted by PV autoimmunity. Anti-alpha9 antibody stained keratinocytes in a fishnet-like intercellular pattern, and visualized a single band at approximately 50 kd in Western blots of keratinocyte membrane proteins. Using step-by-step reverse transcription polymerase chain reactions with primers based on known alpha9 sequence regions, we identified the complete reading frame of human alpha9. Its amino acid sequence showed 85% similarity with rat alpha9. Treatment of keratinocyte monolayers with anti-alpha9 antibody induced pemphigus-like acantholysis, which could be reversed either spontaneously or by using the cholinergic agonist carbachol. We conclude that alpha9 is coupled to physiological regulation of keratinocyte adhesion, and its interaction with PV IgG may lead to blister development.  (+info)

Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. (5/42)

Pemphigus is an autoimmune disease of skin adhesion associated with autoantibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (Dsg) 1 and 3 and acetylcholine receptors. The notion that anti-Dsg antibodies alone are responsible for blisters in patients with pemphigus vulgaris (PV) stems from the ability of rDsg1 and rDsg3 to absorb antibodies that cause PV-like skin blisters in neonatal mice. Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. We injected into Dsg 3-lacking mice the PV IgGs that did not cross-react with the 160-kDa Dsg 1 or its 45-kDa immunoreactive fragment and that showed no reactivity with recombinant Dsg 1. We used both the Dsg3(null) mice with a targeted mutation of the Dsg3 gene and the "balding" Dsg3(bal)/Dsg3(bal) mice that carry a spontaneous null mutation in Dsg3. These PV IgGs caused gross skin blisters with PV-like suprabasal acantholysis and stained perilesional epidermis in a fishnet-like pattern, indicating that the PV phenotype can be induced without anti-Dsg 3 antibody. The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice. Therefore, mucocutaneous lesions in PV patients could be caused by non-Dsg antibodies.  (+info)

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris. (6/42)

Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes that is caused by anti-desmoglein 3 IgG autoantibodies. Recently, we generated an active disease mouse model for pemphigus vulgaris by adoptive transfer of splenocytes from immunized desmoglein 3-/- mice to Rag2-/- mice. In this study, we performed immunologic and histopathologic studies using this pemphigus vulgaris model in mice and compared the gross and microscopic phenotypes of pemphigus vulgaris model mice and desmoglein 3-/- mice. Pemphigus vulgaris model mice showed strong in vivo IgG, and weak IgA deposition on keratinocyte cell surfaces in stratified squamous epithelia, and produced circulating anti-desmoglein 3 IgG antibodies without apparent cross-reactivity to desmoglein 1, in enzyme-linked immunosorbent assays. The predominant IgG subclass was IgG1. Pemphigus vulgaris model mice and desmoglein 3-/- mice were almost indistinguishable in terms of both gross and microscopic findings. Both types of mice showed suprabasilar acantholysis in the stratified squamous epithelia, including the oral mucous membranes and traumatized skin around the snout or paws; however, some pemphigus vulgaris model mice demonstrated a more severe phenotype than desmoglein 3-/- mice. The esophagus and forestomach were affected in some pemphigus vulgaris model mice, but not in desmoglein 3-/- mice. Furthermore, eosinophilic spongiosis, which is found in early pemphigus vulgaris lesions in patients, was observed in pemphigus vulgaris model mice but not in desmoglein 3-/- mice. Pemphigus vulgaris model mice reflect several of the histopathologic and immunologic features seen in pemphigus vulgaris patients, and provide a valuable tool to investigate the pathophysiologic mechanisms of pemphigus vulgaris.  (+info)

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. (7/42)

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease that is caused by IgG autoantibodies against the cadherin-type adhesion molecule desmoglein (Dsg)3. Previously, we have generated an active mouse model for PV by adoptive transfer of Dsg3(-/-) splenocytes. In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation. Intraperitoneal inoculation of the AK23 hybridoma, but not the other AK hybridomas, induced the virtually identical phenotype to that of PV model mice or Dsg3(-/-) mice with typical histology of PV. Epitope mapping with domain-swapped and point-mutated Dsg1/Dsg3 molecules revealed that AK23 recognized a calcium-dependent conformational epitope on Dsg3, which consisted of the V3, K7, P8, and D59 Dsg3-specific residues that formed the adhesive interface between juxtaposed Dsg, as predicted by the crystal structure. The epitopes of the mAbs that failed to show apparent pathogenic activity were mapped in the middle to carboxyl-terminal extracellular region of Dsg3, where no direct intermolecular interaction was predicted. These findings demonstrate the pathogenic heterogeneity among anti-Dsg3 IgG Abs due to their epitopes, and suggest the direct inhibition of adhesive interaction of Dsg as an initial molecular event of blister formation in pemphigus.  (+info)

A case of focal acantholytic dyskeratosis occurring on both the lip and the anal canal. (8/42)

Focal acantholytic dyskeratosis has a distinctive histological pattern that is associated with various clinical expressions. It rarely occurs on the lip or the perianal area. We report a patient with focal acantholytic dyskeratosis occurring on both the upper lip and the anal canal. Histopathologically, the lesions showed hyperkeratosis, suprabasilar clefting, epidermal acantholysis and dyskeratosis. This case represents the first report of a focal acantholytic dyskeratosis occurring on both the lip and the anal canal.  (+info)

Grovers disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with or without dyskeratosis. Once confirmed, most cases of Grovers disease last six to twelve months, which is why it was originally called "transient". However it may last much longer. Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis. Grovers disease often starts quite suddenly. There are intensely itchy spots on the central back, mid chest and occasionally elsewhere. Frequently, it follows sweating or some unexpected heat stress. The itchy eruption lasts an average of 10-12 months. It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs. The papules are most commonly found on the mid chest. Sometimes the features of Grovers are found in people who do not itch or have a conspicuous rash. Most of the people with Grovers who visit a dermatologist, however, itch a ...
ACANTHOLYSIS: Review the definition, meaning, pronunciation, explanation, synonyms, and antonyms of the term ACANTHOLYSIS in the Online Dictionary. What is a 12 letter word that starts with A?
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TY - JOUR. T1 - (3) Calcium enhances the sensitivity of immunofluorescence for pemphigus antibodies. AU - Matis, W. L.. AU - Anhalt, Grant James. AU - Diaz, L. A.. AU - Rivitti, E. A.. AU - Martins, C. R.. AU - Berger, Robert. PY - 1988. Y1 - 1988. UR - http://www.scopus.com/inward/record.url?scp=84988103834&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84988103834&partnerID=8YFLogxK. U2 - 10.1111/j.1365-2133.1988.tb05377.x. DO - 10.1111/j.1365-2133.1988.tb05377.x. M3 - Article. AN - SCOPUS:84988103834. VL - 119. SP - 42. JO - British Journal of Dermatology. JF - British Journal of Dermatology. SN - 0007-0963. ER - ...
AFX is a superficial fibrohistiocytic tumor that presents on the head and neck of elderly patients and is usually a pink or red, solitary, firm, asymptomatic papule or nodule.2,3 Histologically, AFX reveals a dermal proliferation of spindle and epithelioid cells with (often marked) pleomorphism, bizarre mitotic figures, and multinucleated cells.3 There are many variants of AFX, including spindle cell nonpleomorphic, clear cell, osteoclastic, and granular cell.3 Cutaneous squamous cell carcinoma (SCC) has a very diverse range of clinical and pathological subtypes including, but not limited to, acantholytic poorly differentiated and spindle cell.4 A patient with a forehead lesion containing both an SCCis arising within the wall of a trichilemmal cyst and surrounding AFX has been previously reported.1 AFX and SCC occurring together on the conjunctiva5 and face6 of patients with xeroderma pigmentosum have also been reported. It is not surprising to observe a collision of SCCis (or SCC) and AFX ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result
By Professor Martin M Black, MD. Pemphigus and its variants are rare autoimmune disorders characterized by loss of cell to cell cohesion between keratinocytes leading to intra-epidermal blistering. In all types of pemphigus, antibodies are directed against antigens in the intercellular substance between keratinocytes and in a substantial number of active cases, these pemphigus antibodies can be detected in the general blood circulation.. Pempigus vulgaris (PV) is characterized by flaccid blistering and erosions of the skin and mucous membranes. Involvement within the mouth may often precede the skin erosions and may persist even long after skin lesions subside. It is therefore important to remember that involvement of the oral cavity may take the patient to see dental surgeon, rather than a dermatologist in the first instance. However, in pemphigus foliaceus (PF) the blistering tends to be more superficial than in the vulgaris form of pemphigus and the mucous membrane areas are not ...
The first contribution to the chapter will require editorial approval before being published. Only high quality extensive reviews will be approved for initial publication.. Publishing on Dermpedia is easy. If you already have suitable content on file, it will not take much more than cut and paste to publish it on Dermpedia. Please see help for instructions. Dermpedia is designed to be user-editable, but yes, if you have great content, would like to become the Editor of this page, but have not time to edit this page, we will find helpers to publish it for you.. Registration is required.. Adding Cases and Images. You can add cases to book pages and either add images directly or attached to cases (preferred).. Add a case: Click on the Add a case link while on the book page and you will be asked to create a new case by filling in the necessary fields and pressing submit. Once youve done that, there is the further opportunity to add images to the case.. Add an image: Click on the Add an image ...
ASCC Student ID Card Fee The Student ID Card provides a college picture ID for use in campus labs, the library, the bookstore, and other locations on campus. It helps fund student jobs, student activities, critical campus programs and services, as well as providing discounts within the community. For more information about the ASCC card, see ASCC Student ID Card. This optional fee is nonrefundable once the semester begins. The ASCC card fee is not an eligible tax credit fee. The ASCC Student ID Card is to be purchases/renewed each semester, even if a student has already had her or his picture taken.. If the ASCC Student ID Card is lost, stolen, or mutilated, the student will be provided, free of charge, one replacement during the students Cuesta career. For any additional cards there is a $2 replacement fee. Contact the Student Life and Leadership Office at (805) 546-3289 for picture ID dates, times, and information.. Student Representation Fee A vote of the students during the Spring 2002 ...
In mammalian tissues, uptake of Ca(2+) and Mn(2+) by Golgi membranes is mediated by the secretory pathway Ca(2+) -ATPases, SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes. Loss of one copy of the ATP2C1 gene, which causes SPCA1 haploinsufficiency, leads to squamous cell tumors of keratinized epithelia in mice and to Hailey-Hailey disease, an acantholytic skin disease, in humans. Although the disease phenotypes resulting from SPCA1 haploinsufficiency in mice and humans are quite different, each species-specific phenotype is remarkably similar to those arising as a result of null mutations in one copy of the ATP2A2 gene, encoding SERCA2, the endoplasmic reticulum (ER) Ca(2+) pump ...
Insights from a desmoplakin mutation identified in lethal acantholytic epidermolysis bullosa.. J Invest Dermatol. 2010 Nov;130(11):2680-3. Authors: Hobbs RP, Han SY, van der Zwaag PA, Bolling MC, Jongbloed JD, Jonkman MF, Getsios S, Paller AS, Green KJ. PMID: 20613772 [PubMed - indexed for MEDLINE]. ...
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1LWN: Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
Define pemphigus vulgaris. pemphigus vulgaris synonyms, pemphigus vulgaris pronunciation, pemphigus vulgaris translation, English dictionary definition of pemphigus vulgaris. n. Any of several acute or chronic skin diseases characterized by groups of itching blisters. pem′phi·gous adj. n pathol any of a group of blistering skin...
RESULTS: Of the 72 patients, 63 (88%) were men, and the mean age was 48 years (range, 31 to 85). Lesions were distributed mainly on the trunk (in 71 patients) and proximal extremities (in 25). Heat and sweating frequently were exacerbating factors. Fifteen patients (21%) were bedbound. Concurrent nondermatologic malignant disease was present in 18 patients (25%). Two patients (3%) had acquired immunodeficiency syndrome. Follow-up in 28 patients (mean, 38 months; range, 3 months to 7 years) revealed that the disease had recurred in 13, persisted in 3, and resolved in 12. Review of the biopsy specimens showed that acantholysis was pemphigus vulgaris-like in 40 patients (56%), Dariers disease-like in 16 (22%), spongiotic in 12 (17%), pemphigus foliaceus-like in 2 (3%), and Hailey-Hailey disease-like in 2 (3%). A perivascular lymphocytic infiltrate of varied intensity in 64 specimens (89%) was associated with eosinophils in 16 (22%). In nine biopsy specimens with dermal eosinophilia stained for ...
The American Samoa Community College (ASCC) will hold its 67th commencement ceremony on Friday, December 15th, at 10 a.m. in the Colleges gymnasium. Governor Lolo M. Moliga and other dignitaries have been invited to join this semesters celebration of the young men and women who have completed their degrees and certificates, including three students who have earned their Bachelor in Education (BEd) diplomas. A preliminary count of 103 ASCC graduates will celebrate an important milestone in their lives, though the actual number may change depending on examination results or other factors.. As always, the College has sought out a distinguished member of the community to offer words of congratulations and encouragement to the graduates. ASCC alumnus William Ena Spitzenberg may not be as well-known as some of the previous speakers, but he has traveled far, made advancements within his chosen career, and has now returned home to contribute to the betterment of his home, just as many young American ...
Anal Squamous Cell Carcinoma (ASCC) is an uncommon cancer with an incidence rate between 1 and 2 per 100000 per year. However, the incidence of ASCC is increasing rapidly, with up to 6.8% increase in men per year and 10.7% increase in women per year since 1971.. It is believed that the increasing numbers of HIV positive patients who are living longer on advanced antiretrovirals are likely to be contributing to the increasing burden of ASCC. Anal Intraepithelial Neoplasia (AIN) is the known precursor to ASCC. It is believed that by identifying and treating high grade AIN that ASCC could become a preventable cancer. ASCC also has excellent outcomes if identified early. Only 15% of ASCC present with metastasis and most patients are diagnosed with resectable T1 tumours. However, current guidelines are conflicting and not based on good quality clinical evidence, The limiting factor to providing good quality evidence is the large samples size required to observe the relationship between AIN ...
DARIERS DISEASE. What are the aims of this leaflet?. This leaflet has been written to help you understand more about Dariers disease. It tells you what it is, what causes it, what can be done about it, and where you can find out more about it.. What is Dariers disease?. It is a rare inherited skin condition characterised by the loss of binding (acantholysis) between skin surface cells and there is also some thickening of the skin. It is also known as Keratosis Follicularis. The nails and mouth may also be affected.. What causes Dariers disease?. It is the result of an abnormality in the gene involved in calcium transport within cells. The defective calcium transport leads to reduced cell binding. Normally, in the outer layer (epidermis) of the skin, the skin cells are held together like bricks cemented in a wall. In Dariers disease the sticky junctions that hold the skin cells together are not made properly, and the skin may be easily irritated and becomes inflamed and weeping. It is not ...
It isnt often that a high level official such as the Director of the National Oceanic and Atmospheric Administration (NOAA) Office of the National Marine Sanctuaries (ONMS) travels to American Samoa and makes time to speak with college students.. The American Samoa Community College (ASCC) was honored to have Mr. John Armor, Director of ONMS, spend an hour talking with ASCC Marine Science Program and Agriculture, Community and Natural Resource (ACNR)/Land Grant students on March 31st.. Armor spoke about how he fell in love with the ocean at a young age, and how he persevered throughout his career to ultimately end up where he is today, as the Director of the entire National Marine Sanctuary program.. He recounted the hard work he put into seeking out opportunities in his field of interest, and how important it is to not be discouraged if you arent accepted to your first, second, or even third attempts to get a job or an internship.. Armor shared how his first marine internship after college ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
Javier Rangel, MD Perm J 2016 Winter; 20(1):e101-e102 http://dx.doi.org/10.7812/TPP/15-059 Abstract The development of pemphigus, including
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Santa, Mrs. Claus and the Hoisington Chamber of Commerce staff agree, tonight is not a great night for be out and about. So, they are rescheduling the Christmas Lighting celebration to Tuesday, Dec. 8. The city lights will still be turning on tonight, but plan to come up to the Chamber and Santa House on Dec. 8 to see Santa and Mrs. Claus, enjoy cocoa and cookies and sign up for Chamber Gift Certificates and the 50/50 Winter raffle. ...
Risks for Pemphigus foliaceus, Pemphigus foliaceus treatments, recommended products for Pemphigus foliaceus, ways to prevent Pemphigus foliaceus, causes of Pemphigus foliaceus
TY - JOUR. T1 - Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. AU - Kamiya, K.. AU - Aoyama, Y.. AU - Yamasaki, O.. AU - Kamata, A.. AU - Yamagami, Jun. AU - Iwatsuki, K.. AU - Tokura, Y.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Background Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are closely related, but clinically distinct, autoimmune blistering diseases caused by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. Using ethylenediaminetetraacetic acid (EDTA)-treated Dsg3 enzyme-linked immunosorbent assay (ELISA) we have shown that the proportion of anti-Dsg3 antibodies against calcium-dependent epitopes decreased upon shifting to the inactive phase in patients with PV. Objectives To analyse the epitope profiles of anti-Dsg1 antibodies across the different activity stages of PF. Methods We evaluated five patients with PF who retained high serum levels of anti-Dsg1 antibodies in the inactive phase. ...
HAILEY-HAILEY DISEASE. What are the aims of this leaflet?. This leaflet has been written to help you understand more about Hailey-Hailey disease. It tells you what it is, what causes it, what can be done about it, and where you can find out more about it.. What is Hailey-Hailey disease?. Hailey-Hailey disease is also known as familial benign chronic pemphigus, as originally described by the Hailey brothers. It is a rare inherited skin condition in which red scaly areas that can be itchy and sore, can lead to superficial blisters and eroded (broken) areas of the skin folds of the groin, armpits, neck and under the breasts. The condition flares intermittently and tends to come and go. Many patients are able to lead full and normal lives, with their condition being a nuisance rather than a serious problem. Some patients are more severely affected and experience more persistent painful raw areas of the skin with development of superficial blisters.. What causes Hailey-Hailey disease?. A small error ...
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a com
What is Pemphigus Vulgaris or Skin & mouth Blisters? Get treatment for blisters on Skin & in Mouth. The Esthetic Clinic provides the best in class treatment for Pemphigus Vulgaris or Skin & mouth Blisters in Mumbai and India. Best Dermatologist for skin diseases, Contact details - [email protected] or +91-9004671379
Desmoglein 3 antibody [3G133] (desmoglein 3) for ICC/IF, IHC-P, IP, WB. Anti-Desmoglein 3 mAb (GTX14416) is tested in Human samples. 100% Ab-Assurance.
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Pemphigus foliaceus is a rare autoimmune disorder that causes people to have skin that blisters easily and develops crusty, scaly...
Pemphigus Vulgaris is mainly characterized by a formation of blisters in the mouth which make it difficult to swallow food or drink water. These blisters later
Polyclonal antibody for Desmoglein 3/DSG3 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Desmoglein 3/DSG3 information: Molecular Weight: 107533 MW; Subcellular Localization: Cell membrane ; Single-pass type I
Rabbit recombinant monoclonal Desmoglein 1 antibody [EPR6766(B)] validated for WB, IHC and tested in Human, Mouse and Rat. Referenced in 1 publication and 4…
The rest of December went well, eye healing up and skin was getting better. After the surgery Otis started to gain weight and muscle. I think the eye was bothering him for much longer than we knew. Somewhere in the back of my mind I crossed my fingers that the tumor had caused all of…
This weeks colors are B24, G24 and Y21 and any other green. As with all Kimms Copic Challenges, you can use 1,2 or all 3 of her color suggestions (or something close). The names of the colors really grabbed me - Sky, Willow, and Buttercup Yellow! These enticing descriptors got me thinking about the summer fields and open sky. Looking around my craft area, I realized I had just enough (formerly) 12" x 12" cardstock to make one last Triple Play card, a Technique Junkie idea that makes a card that fits in a regular #10 envelope. That got me thinking about snail mail...and well the rest is history! ...
Argenx discovers, designs and develops innovative antibody therapeutics for its own pipeline of treatments for cancer and autoimmune diseases and for its partners. Harnessing our technology and know-how, we aim to meet the needs of patients by engineering antibodies to target diseases too complex for other antibody technologies.
This rare autoimmune disorder caused a womans vulva to swell up and break out in blisters. We spoke to a dermatologist to find out how that happens.
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
TY - JOUR. T1 - Pemfigo radioindotto con ritardo diagnostico. AU - Hendrickx, I.. AU - Guizzardi, M.. AU - Mancini, L. L.. AU - Monti, M.. PY - 1999. Y1 - 1999. N2 - Ionizing radiation-induced pemphigus is a rare reported clinical entity, arising after a radiation therapy that usually follows surgical treatment for malignancy. A case of ionizing radiation-induced pemphigus arised after X-ray therapy for mammary carcinoma is reported. After two weeks of X-ray delivery, erythema and erosions appeared on the radiated area. These lesions were interpreted as an inflammatory result of radiation and cured. After eighteen months, typical pemphigus bullous eruptions developed all over the body and oral mucosa. The importance of considering ionizing radiation-induced pemphigus among the attending side effects of radiotherapy is underlined and it is suggested to submit to dermatological attention every case of uncertain skin reaction.. AB - Ionizing radiation-induced pemphigus is a rare reported clinical ...
Background: Pemphigus is a rare, autoimmune blistering condition, resulting in significant morbidity and mortality. It warrants treatment by various immunosuppressive age..
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TY - JOUR. T1 - Neonatal pemphigus vulgaris. T2 - IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. AU - Parlowsky, Thomas. AU - Welzel, Julia. AU - Amagai, Masayuki. AU - Zillikens, Detlef. AU - Wygold, Thorsten. PY - 2003/4/1. Y1 - 2003/4/1. N2 - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.. AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy ...
Paraneoplastic pemphigus is an autoimmune acantholytic mucocutaneous disorder that rarely accompanies an overt or occult neoplasm. Typical features include painful mucosal erosive lesions and pruritic papulosquamous eruptions that often progress to blisters. The antibody is a unique immunoglobulin G that recognises epidermal proteins. We discuss the case of a 23-year-old woman who presented with anaplastic large cell lymphoma complicated by paraneoplastic pemphigus, rapidly resulting in fatal multiorgan failure.. A 23-year-old woman presented with 1 week of fever and a disseminated erythrodermic rash with desquamation of the hands and feet, and erosions in the mouth. A local doctor started treatment with ciprofloxacin and prednisolone ...
Background: Captopril is an angiotensin-converting enzyme inhibitor with sulphydryl groups in its chemical structure. It is commonly used as an antihypertensive drug. The occurrence of pemphigus vulgaris has repeatedly been reported in patients receiving captopril. The capacity of captopril and pemphigus serum to induce acantholysis, in vivo or in vitro, has been demonstrated experimentally. Objectives: To show that captopril and pemphigus serum, acting by a biochemical and immunological mechanism, respectively, trigger apoptosis. Methods: Human keratinocyte cells were treated with 15 mmol L)1 captopril or with pemphigus serum. DNA was extracted and the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling method was used to detect apoptosis. Results: DNA fragmentation occurred after 72 h of treatment. Increased expression of p53, c-myc and inducible nitric oxide (NO) synthase (iNOS) mRNA were observed by polymerase chain reaction (PCR) in the treated cells ...
In patients with pemphigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3) cause loss of cell-cell adhesion of keratinocytes in the basal and immediate suprabasal layers of stratified squamous epithelia. The pathology, at least partially, may depend on protease release from keratinocytes, but might also result from antibodies interfering with an adhesion function of Dsg3. However, a direct role of desmogleins in cell adhesion has not been shown. To test whether Dsg3 mediates adhesion, we genetically engineered mice with a targeted disruption of the DSG3 gene. DSG3 -/- mice had no DSG3 mRNA by RNase protection assay and no Dsg3 protein by immunofluorescence (IF) and immunoblots. These mice were normal at birth, but by 8-10 d weighed less than DSG3 +/- or +/+ littermates, and at around day 18 were grossly runted. We speculated that oral lesions (typical in PV patients) might be inhibiting food intake, causing this runting. Indeed, oropharyngeal biopsies showed erosions with histology
This page includes the following topics and synonyms: Pemphigus Foliaceus, Superficial Pemphigus, Pemphigus erythematosus, Senear-Usher Syndrome, Fogo selvagem, Pemphigus herpetiformis.
... , Mona Afrasiabi, Shabnam Esmaeilinejad, Vahid Asgary, Reza Ahangari Coh
Pemphigus vulgaris is an autoimmine disorder, where the bodys immune system attacks some of the proteins in the skin. Pemphigus usually occurs in middle-aged or older people. This picture shows a close-up
Tong, J.C.,Tan, T.W.,Ranganathan, S.,Sinha, A.A. (2006). Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris. BMC Bioinformatics 7 (SUPPL.5). [email protected] Repository. https://doi.org/10.1186/1471-2105-7-S5-S7 ...
Indication: adult patients with pemphigus vulgaris and pemphigus foliaceus.. SAMEP recommendation: To list rituximab on the statewide high cost medicines formulary for adult patients with pemphigus vulgaris and pemphigus foliaceus who are refractory to conventional immunosuppression or who are steroid-dependent.. Rationale: Rituximab, in combination with short term prednisone, can induce remission in newly diagnosed pemphigus patients with a lower total prednisone dose than if relying on prednisone alone. The majority of patients treated with rituximab experienced at least one episode of complete remission off therapy (89%) at two years as compared to approximately a third (34%) of patients only receiving prednisone.. The rate of relapse at 24 months also favoured rituximab treated patients (24% versus 45%) and fewer patients in the rituximab arm had active lesions at 24 months or had no lesions but remained on significant prednisone doses (11% versus 64%). Rituximab has a steroid sparing effect ...
Pemphigus foliaceus is one of the most common autoimmune diseases in dogs, leading to autoantibodies to desmoglein I and finally to pustule and crust formation. Immunosuppressive therapy is mandatory in this disease - but does it always have to be given for the rest of the life? An interesting, rarely discussed question!
NADAL, Sidney Roberto and CRUZ, Sylvia Heloisa Arantes. Follow-up for HIV negative and HIV-positive patients with anal squamous cells carcinoma. Rev bras. colo-proctol. [online]. 2009, vol.29, n.3, pp.404-407. ISSN 0101-9880. http://dx.doi.org/10.1590/S0101-98802009000300018.. Anal squamous cell carcinoma (ASCC) and anal intra-epithelial neoplasia (AIN) incidences are bigger among human papillomavirus (HPV) infections, and are associated to immunity and to HIV infection. These viruses with sexual transmission in association suggested ASCC is a sexually transmitted tumor. HIV infection changed ASCC patient profile. This kind of tumor committed women in theirs sixties, but nowadays, affects mainly men in the third and forth decades of life. In the United States of America, ASCC was diagnosed in 19/100.000, in the pre-HAART (highly active anti-retroviral therapy) era (1992-1995), came to 48,3/100.000 in the immediate post-HAART period (1996-1999) and increased to 78,2/100.000 people per year from ...
Corneal involvement is a rare complication in patients with pemphigus vulgaris. Severe corneal involvement has never been reported except in the case of a 56 year old man with severe ocular involvement including conjunctivitis, corneal ulceration, and perforation despite immunosuppressive therapy.4 Although a causative organism was not isolated, the authors suggested that the complications were due to an infectious agent.. Two mechanisms have been suggested to cause the corneal erosion-bacteria or other pathogenic organisms that infect the cornea because of the epithelial defect and tear film disorder brought on by the corticosteroid and immunosuppressive therapy. Although the culture obtained from right ocular discharge before starting ofloxacin ointment showed a negative result, we could not deny the bacterial infection. We did not perform a bacterial or viral culture or polymerase chain reaction examinations using a corneal sample.. The second mechanism is an autoimmune mechanism against one ...
Annales de Dermatologie et de Vénéréologie - Vol. 139 - N° 10 - p. 621-625 - Détection danticorps antidesmogléines circulants chez un patient atteint de maladie de Hailey-Hailey - EM|consulte
Download Pemphigus Disease. Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek root pemphix meaning...
Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA, Kory M, Izumi H, Ratrie H III, Mutasim D, Ariss-Abdo L, and Labib RS: A novel autoimmune mucocutaneous syndrome, associated with underlying neoplasia: "Paraneoplastic Pemphigus". N Engl J Med 323:1729-1735, 1990 ...
Patch testing is sometimes indicated. It should only be performed by a specialist practitioner, as reactions may be severe.. ...
What is pemphigus? It is a disease where the immune system attacks healthy cells resulting in blisters. Learn the phemigus types, treatment & more.
Background Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown. Methodology/Principal Findings Using an immunoprecipitation and mass spectrometry based approach, we identified p170 as alpha-2-macroglobuline-like-1, a broad range protease inhibitor expressed in stratified epithelia and other tissues damaged in the PNP disease course. We demonstrate that 10 PNP sera recognize alpha-2-macroglobuline-like-1 (A2ML1), while none of the control sera obtained from patients with bullous pemphigoid, pemphigus vulgaris, pemphigus foliaceus and normal subjects does. Conclusions/Significance Our study
Paraneoplastic pemphigus. Close-up of paraneoplastic pemphigus (PNP) lesions on the shoulder and chest of a 60-year-old male patient with non-Hodgkins lymphoma, a form of blood cancer. PNP is an autoimmune disease resulting from an underlying tumour. It is thought that antigens associated with the tumour trigger an immune response that results in blistering of the skin near the tumour. Non-Hodgkins lymphoma is one of the two malignant tumours most commonly associated with PNP. Prognosis is poor. - Stock Image C029/2399
Those with benign familial chronic pemphigus have a decreased number of desmosomes in the skin. Desmosomes are like little rivets that hold the skin cells together. Because the skin cells are not as attached together as well as normal skin, conditions such as heat and frictional pressures may cause Hailey-Hailey disease to flare.. Benign Familial Chronic Pemphigus is a genetic disease. The predisposition to get this disease is carried within your genes. Children of affected people have a fifty-fifty chance of also getting the disease. About one third may get the condition without a family history.. ...
Background:Pemphigus is a life-threatening, autoimmune blistering disease, mediated by IgG autoantibodies. The aim of our study was to assess the usefulness of a new enzyme-linked immunosorbent assay (ELISA) in detecting circulating pemphigus autoantibodies, and to compare its sensitivity and specificity with the indirect immunofluorescence (IIF) test. We also established the frequency of occurrence of pemphigus autoantibodies in relatives of our patients.Material/Methods:IIF and ELISA tests were performed in 24 patients with pemphigus vulgaris, 13 with pemphigus foliaceus, 56 healthy relatives, and 50 controls, selected according to sex and age.Results:The obtained results revealed high specificity and sensitivity of ELISA, comparable to the IIF test, especially in patients who were in the active stage of the disease. We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus. The frequency of occurrence of pemphigus ...
What is Bullous Pemphigoid? What is Bullous Pemphigoid ? Large blisters start appearing on the body with severe itching and inflammation this is the time for the treatment and diagnosis of bullous pemphigoid. This is a chronic auto immune disease that blisters the skin in a severe manner. Sometimes mucous membrane tissues are also involved … Continue reading ». ...
Pemphigus describes a group of autoimmune blistering diseases that involve the epidermal surfaces of the skin, mucosa, or both. There are 3 broad categories: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP). Pemphigus is mediated by an autoantibody that binds a specific component of the desmosomal plaque. The desmosomal plaque holds the keratinocytes of the skin and mucosa together. ...
PepTivator® Desmoglein is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the pemphigus vulgaris antigen Desmoglein-3 (UniProt ID: P32926) . In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. - Deutschland
PepTivator® Desmoglein is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the pemphigus vulgaris antigen Desmoglein-3 (UniProt ID: P32926) . In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. - Lëtzebuerg
K/BxN serum-induced passive arthritis was reported to depend on the activation of mast cells, triggered by the activating IgG receptor FcγRIIIA, when engaged
TY - JOUR. T1 - Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma. AU - Chamseddin, Bahir H.. AU - Lee, Eunice E.. AU - Kim, Jiwoong. AU - Zhan, Xiaowei. AU - Yang, Rong. AU - Murphy, Kathleen M.. AU - Lewis, Cheryl. AU - Hosler, Gregory A.. AU - Hammer, Suntrea T.. AU - Wang, Richard C.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Anal squamous cell carcinoma (ASCC) is a rare, potentially fatal malignancy primarily caused by high-risk human papillomaviruses (HPV). The prognostic implication of programmed death-ligand 1 (PD-L1) expression remains controversial, and glucose transporter 1 (GLUT1) expression has never been examined in ASCC. Covalently closed circular RNAs have recently been shown to be widespread in cancers and are proposed to be biomarkers. We discovered HPV16 expresses a circular E7 RNA (circE7) which has not been assessed as a potential biomarker. A retrospective, translational case series at UT Southwestern was conducted to analyze PD-L1, GLUT1, ...
RESULTS: Thirty-five patients were included. Clinical phenotypes were: mucosal in 17 patients; mucous-cutaneous in 11; and cutaneous in 7. The status of anti-Dsg1 autoantibodies was significantly related to the cutaneous and mucous-cutaneous phenotypes both at diagnosis and after 6 months. The status of anti-Dsg3 autoantibodies was significantly related to the mucosal and mucous-cutaneous phenotypes only at first evaluation. No significant correlations were found between disease activity and the status of autoantibodies. No significant variations of autoantibody levels (between first and second sample) were found with regard to different therapies, except for the variation of anti-Dsg1 autoantibodies in one patient treated with systemic steroids and methotrexate ...
Background: The use of saliva for the diagnosis of pemphigus vulgaris (PV) by enzyme-linked immunosorbent assay (ELISA) using desmoglein (Dsg)3 antigen has not been extensively documented, nor has the detection of serum IgA antibodies to Dsg3. Objectives: (i) To establish whether whole saliva might provide a suitable alternative to serum for diagnosing and monitoring PV; (ii) to investigate whether anti-Dsg3 IgA antibodies can be detected in serum and saliva and (iii) to establish whether there is an association between serum or saliva anti-Dsg3 antibodies and disease severity. Methods: Precoated Dsg3 ELISA plates were used to test serum and/or saliva for IgG and IgA antibodies. Matched serum and whole saliva samples were collected from 23 patients with PV, 17 healthy subjects and 19 disease controls. All patients with PV, disease controls and six healthy controls provided matched parotid saliva. Results: Whole saliva IgG antibodies to Dsg3 were detected in 14 of 23 patients (61%) and serum IgG ...
Background & Objective: Chronic non healing ulcers or scar undergoing malignant transformation is a rare phenomenon with an estimated incidence of 2%. Though, numerous predisposing factors have been identified, still it is rarely diagnosed and commonly mistaken for a benign condition. The objective of this study was to verify the efficacy of the Fine Needle Aspiration Cytology/ Scrape cytology of chronic non healing ulcers, and its use in the early detection of the malignant transformation, thereby facilitating early management. Methods: A total of 10 cases of chronic non healing ulcer with malignant transformation were included in the study where the initial diagnosis was made on Fine Needle Aspiration Cytology/Scrape cytology and later on confirmed on histopathology. Results: Squamous cell carcinoma (7 cases), acantholytic variant of Squamous Cell Carcinoma (1 case), malignant fibrous histiocytoma (1 case) and carcinosarcoma (1 case) was seen. A 100% concordance with histopathology was seen in
by Lori , May 7, 2017 , Auto immune disorders, Candida Overgrowth Treatment, Pemphigus vulgaris, Skin disorders, Success Stories. Pemphigus Vulgaris is a terrible skin disorder, which is one of the autoimmune disorders. This success story is from a real person, whose name is left out for privacy reasons. She wrote to use on May 4, 2017, and gave us permission to publish her story about how she ...
Are You Confident of the Diagnosis? What you should be alert for in the history Characteristic findings on physical examination Expected results of diagnostic studies [histopathology, serologic tests, genetic tests, imaging studies] Diagnosis confirmation [Describe those conditions in the differential diagnosis that may reasonably mimic the diagnosis and explain their distinction] Pemphigus foliaceus (PF) and…. ...
Free, official coding info for 2018 ICD-10-CM L08.81 - includes detailed coding rules & notes, synonyms, ICD-9-CM conversion, index & annotation crosswalks, DRG grouping and more.
globular galls at the base of of a green shoot, green, reddish around the exit opening. The gall is maximally 2.5 cm large, and invariably solitary. ...
Paraneoplastic pemphigus is an autoimmune disorder stemming from an underlying tumor. It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes. While patients with malignant and benign tumors are both at risk, malignancy is associated with high mortality rates (near 90%). Current treatment focuses on general wound healing and administering corticosteroids, which has not demonstrated a high success rate. Recent research developments aim to treat the underlying tumor in order to alleviate the symptoms of PNP. While the presence of lesions is the denominator among patients with PNP, the characteristics of the lesions differ. The five clinical presentations of lesions associated with PNP include: "Pemphigus-like": Flaccid blister (discrete), crusts over the raw exuding skin lesions "Pemphigoid-like": Tense blister(s) on brick red erythema "Erythema multiforme-like": Severe polymorphic skin and/or mucous membrane ...
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folliculitis - MedHelps folliculitis Center for Information, Symptoms, Resources, Treatments and Tools for folliculitis. Find folliculitis information, treatments for folliculitis and folliculitis symptoms.
Autoimmune bullous diseases (ABDs) are uncommon but significant skin disorders with relatively high morbidity and mortality. Some surveys have been carried out to describe the spectrum of ABDs in a region, but this is the first that has focused on ABDs in elderly patients. This study was conducted to determine the clinicoepidemiologic features of ABDs in elderly patients. Medical records of all ABD patients with disease onset after the age of 60 years who presented to the Autoimmune Bullous Diseases Research Center, Tehran, Iran between April 2003 and March 2013 were reviewed ...
1. Pemphigus Foliaceus. Secondly, they can be caused by Pemphigus Foliaceus which is a disorder that results in blisters on the mucous membrane.. 2. Constant trauma. Do not forget also that trauma on the nose has the potential to cause this problem. One example could be blowing it too hard in such a way that there is a rupture in the blood capillaries that can lead to small ulcers.. 3. Infections such as bacteria. Infections like bacterial infection can also this problem. It is important to understand that the nasal passages would normally act as a shield against things like bacteria and dust in the air we breathe. These are well trapped in the mucus on the nose hairs; however, when there is a crack inside the nasal passages, it is possible for the bacteria to cause some infections inside the lining which could cause these nose sores.. Staphylococcus bacteria are known to be one of the most common problems for nasal sores. In fact, the bacteria which are sometimes referred to as staph is ...
ENCODES a protein that exhibits 3-5 DNA helicase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); DNA dealkylation involved in DNA repair (ortholog); DNA duplex unwinding (ortholog); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN activating signal cointegrator 1 complex (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH benzo[b]fluoranthene; cadmium dichloride; carbon nanotube
Hailey-Hailey disease, also known as benign chronic pemphigus, is a rare autosomal dominant cutaneous disorder that usually becomes manifest in the third or fourth decade of life with erythema, vesicles, and erosions involving the body folds, particularly the groin and axillary regions. Other sites of the body, such as the neck, perianal, and submammary regions, may likewise be affected (summary by Poblete-Gutierrez et al., 2004). This disorder was first described by the dermatologist brothers Hailey and Hailey (1939).
When diagnosing folliculitis, a physician will look at the skin, take a clinical history and assess exposure to a variety of risk factors. A skin swab may be taken if usual treatments fail to resolve folliculitis, and this sample will
Folliculitis Treatments - Folliculitis treatments can be very effective. Visit HowStuffWorks to learn about folliculitis treatments.
Question - How can folliculitis be treated?. Ask a Doctor about diagnosis, treatment and medication for Folliculitis, Ask a Dermatologist
I know this is a weird question- but I just started shaving down there a few weeks ago maybe.? Ive noticed some small red bumps, some maybe a bit bigger then others, but still very small, is it Folliculitis, if so how can I stop it, if not, then what is it.? What does Folliculitis look like (you know what I mean)Health Question & Answer ...
Chlorambucil is a very popular drug in feline medicine, especially used in the treatment of autoimmune diseases like pemphigus foliaceus or in neoplastic conditions like lymphoma. Neurotoxicity as a common side effect like in human medicine has never been described - until this cat was treated with chlorambucil.
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Genentech, affiliated to Swiss drug major Roche Group (RHHBY), announced Thursday that the Phase III PEMPHIX Study with Rituxan (Rituximab) in patients with Pemphigus Vulgaris or PV met the primary and secondary endpoints.
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A tongue that is in good shape is taken as a prime indicator of your overall body being in the pink of health, and vice versa. So, conditions like tongue blisters can very well be symptomatic of some other grave health scare that might merit medical attention. This makes it all the more necessary not to take them lightly, and see a doctor immediately to ascertain the cause and get it treated accordingly.. The general rule of thumb recommended by medical experts is that if the blisters persist for longer than 2 weeks despite the prescribed primary treatment and care, the discomfort becomes unmanageable such that it keeps you from going about your daily business, or the condition tends to worsen progressively and is accompanied by fever. It is best to seek the help of your dentist to rule out the possibility of an oral infection or conditions that are rarer, such as pemphigus vulgaris or oral cancer.. In general, tongue blisters last for about a week and disappear on their own. However, you can ...
A follicle refers to a crust or cavity from which the hair emerges on the surface of the skin. The term folliculitis is used to describe the inflamed condition
This in turn causes a loss of adhesion with acantholysis as a result. The National Institute of Arthritis and Musculoskeletal ...
The pathologist looks for an intraepidermal vesicle caused by the breaking apart of epidermal cells (acantholysis). Thus, the ... a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these blisters can ... and acantholysis. The least common and most severe type of pemphigus is paraneoplastic pemphigus (PNP). This disorder is a ... acantholysis), and by the presence of pathogenic (predominantly IgG) autoantibodies reacting against epithelial adhesion ...
... and acantholysis. Early descriptions were made by Darrell Wilkinson, a British dermatologist. Pemphigus List of cutaneous ...
PV is manifested by suprabasal acantholysis, or blisters in the mucus membrane and blisters in the epidermis. PF patients have ...
Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with ...
This results from the disruption of tonofilaments in the desmosomes with acantholysis and intra-epidermal blister formation. " ...
... characterized by a tubular microscopic pattern and keratinocyte acantholysis. Basaloid squamous cell carcinoma is characterized ...
... are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". J. Clin. ...
... epidermal acantholysis (breaking apart of the skin), dyskeratotic keratinocytes and vacuolar changes in the layers of the skin ... Histologic evidence of acantholysis (loss of intercellular connections leading to breaking apart of the skin; lesion) Direct ...
... pemphigoid does not feature acantholysis, a loss of connections between skin cells. Pemphigoid is more common than pemphigus, ...
... nondyskeratotic acantholysis. List of cutaneous conditions James, William; Berger, Timothy; Elston, Dirk Andrews' Diseases of ...
... causing acantholysis, blisters and rashes. There is no known cure. The differential diagnosis includes intertrigo, candidiasis ...
Hyperkeratosis Parakeratosis Hypergranulosis Acanthosis Papillomatosis Dyskeratosis Acantholysis Spongiosis Hydropic swelling ...
... acantholysis MeSH C17.800.865.187 --- blister MeSH C17.800.865.360 --- dermatitis herpetiformis MeSH C17.800.865.385 --- eczema ...
... is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes ... ISBN 0-7216-0187-1. "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Retrieved 2017-04-22. ...
Disuse atrophy of muscles and bones, with loss of mass and strength, can occur after prolonged immobility, such as extended bedrest, or having a body part in a cast (living in darkness for the eye, bedridden for the legs etc.). This type of atrophy can usually be reversed with exercise unless severe. Astronauts in microgravity must exercise regularly to minimize atrophy of their limb muscles. There are many diseases and conditions which cause atrophy of muscle mass. For example, diseases such as cancer and AIDS induce a body wasting syndrome called cachexia, which is notable for the severe muscle atrophy seen. Other syndromes or conditions which can induce skeletal muscle atrophy are congestive heart failure and liver disease. During aging, there is a gradual decrease in the ability to maintain skeletal muscle function and mass. This condition is called sarcopenia, and may be distinct from atrophy in its pathophysiology. While the exact cause of sarcopenia is unknown, it may be induced by a ...
... is mainly intercellular[1] edema (abnormal accumulation of fluid) in the epidermis,[2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification.[3] It is a severe case of eczema that affects the epidermis, dermis and/or subcutaneous skin tissues.[4][5] The three types of spongiotic are acute, subacute and chronic.[5] A Dermatologist can diagnose acute spongiotic by examining your skin during an office visit but a biopsy is needed for an accurate diagnosis of the type.[6] It can be caused by several internal or external factors such as food, an insect bite, stress, medication or cosmetics. The treatment varies depending on the type and severity; it is normally treated with topical corticosteroid cream.[6] ...
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system-the organ system that encloses the body and includes skin, hair, nails, and related muscle and glands.[1] The major function of this system is as a barrier against the external environment.[2] Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails).[3][4] While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described.[5] Classification of these conditions often presents many nosological challenges, since underlying causes and pathogenetics are often not known.[6][7] Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology (chronic blistering conditions), cause (skin conditions ...
With regard to the quote "...varying in size from a pinhead to 1cm," depending on which text is referenced, some authors state the cutoff between a papule and a plaque as 0.5cm, not 1cm, while others state an entirely different measurement. Therefore, for this article, the 1cm cutoff is used which is discussed in Andrews' Diseases of the Skin: Clinical Dermatology (see references), a work considered by some dermatologists as an authority on this subject matter. See Lack of Standardization for complete discussion. ...
In terms of pathology, the first signs of the condition may be observed within the dermis. The changes that may take place at this level may include edema, vascular dilatation, and cellular infiltration. It is common for lymphocytes and eosinophils to be seen. The bullae found in the skin affected by dermatitis herpetiformis are subepidermal and have rounded lateral borders. When looked at under the microscope, the skin affected by dermatitis herpetiformis presents a collection of neutrophils. They have an increased prevalence in the areas where the dermis is closest to the epidermis. Direct IMF studies of uninvolved skin show IgA in the dermal papillae and patchy granular IgA along the basement membrane. The jejunal mucosa may show partial villous atrophy, but the changes tend to be milder than in coeliac disease.[16] Immunological studies revealed findings that are similar to those of coeliac disease in terms of autoantigens. The main autoantigen of dermatitis herpetiformis is epidermal ...
... is primarily caused by uroporphyrinogen decarboxylase deficiency (UROD). Uroporphyrinogen decarboxylase occurs in nature as a homodimer of two subunits. It participates in the fifth step in heme synthesis pathway, and is active in the cytosol. This enzymatic conversion results in coproporphyrinogen III as the primary product. This is accomplished by the clockwise removal of the four carboxyl groups present in the cyclic uroporphyrinogen III molecule. Therefore, a deficiency in this enzyme causes the aforementioned buildup of uroporphyrinogen and hepta-carboxylic porphyrinogen, and to a lesser extent hexa-carboxylic porphyrinogen, and penta-carboxylic porphyrinogen in the urine, which can be helpful in the diagnosis of this disorder.[16][17] The dermatological symptoms of PCT that include blistering and lesions on sun-exposed areas of the skin are caused by a buildup of porphyrin compounds (specifically uroporphyrinogen) close to the surface of the skin that have been ...
Clinically, the earliest lesions may appear urticarial (like hives), but could also appear dermatitic, targetoid, lichenoid, nodular, or even without visible rash (essential pruritus)[1]. Tense bullae eventually erupt, most commonly at the inner thighs and upper arms, but the trunk and extremities are frequently both involved. Any part of the skin surface can be involved. Oral lesions are present in a minority of cases.[2] The disease may be acute, but typically will wax and wane. Several other skin diseases may have similar symptoms. However, milia are more common with epidermolysis bullosa acquisita, because of the deeper antigenic targets. A more ring-like configuration, with a central depression or centrally collapsed bullae may indicate linear IgA disease. Nikolsky's sign is negative unlike pemphigus vulgaris where it is positive.. ...
The autoimmune reaction most commonly affects the mouth, causing lesions in the gingiva or gums, but it can also affect areas of mucous membrane elsewhere in the body, such as the sinuses, genitals and anus. When the cornea of the eye is affected, repeated scarring may result in blindness. Localized cicatricial pemphigoid (also known as "Brunsting-Perry cicatricial pemphigoid"[1]) refers to a localised variant of cutaneous cicatricial pemphigoid involving the head and the neck without mucosal involvement.[1] Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. In contrast, in Pemphigus, the epithelium tends to disintegrate rather than form a bulla. Nikolsky's sign is present pemphigus and cicatricial pemphigoid, but not in bullous pemphigoid. ...
ത്വക്കിലോ മ്യൂക്കസ് പാളിയിലോ ഉണ്ടാകുന്ന വൃണത്തെയാണ് സാധാരണഗതിയിൽ അൾസർ എന്നു വിളിക്കുന്നത്. ഇതോടൊപ്പം കലകളുടെ നാശവും ഉണ്ടാകും. ഈ വൃണങ്ങൾ കാരണം എപിഡെർമിസും പലപ്പോഴും ഡെർമിസിന്റെയും തൊലിക്കടിയിലുള്ള കൊഴുപ്പിന്റെപോലും നാശമുണ്ടാകാം. കാലുകളിലാണ് കൂടുതലും ത്വക്കിലെ അൾസറുണ്ടാകുന്നത്. തൊലിയിലുണ്ടാകുന്ന അൾസറിനു ചുറ്റും കോശജ്വലനം മൂലം ചുവന്ന തൊലിയാവും ഉണ്ടാവുക. ചൂടോ, ...
acantholysis synonyms, acantholysis pronunciation, acantholysis translation, English dictionary definition of acantholysis. ... Noun 1. acantholysis - a breakdown of a cell layer in the epidermis disease of the skin, skin disease, skin disorder - a ... acantholysis. Also found in: Thesaurus, Medical, Wikipedia.. Related to acantholysis: pemphigus, acanthosis, dyskeratosis, ... Acantholysis - definition of acantholysis by The Free Dictionary https://www.thefreedictionary.com/acantholysis ...
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes ... ISBN 0-7216-0187-1. "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Retrieved 2017-04-22. ...
... and antonyms of the term ACANTHOLYSIS in the Online Dictionary. What is a 12 letter word that starts with A? ... ACANTHOLYSIS: Review the definition, meaning, pronunciation, explanation, synonyms, ...
"Acantholysis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Acantholysis" by people in Harvard Catalyst Profiles by year, ... Below are the most recent publications written about "Acantholysis" by people in Profiles. ... and whether "Acantholysis" was a major or minor topic of these publication. ...
E. Sanchez Yus, L. Requena, P. Simon, and C. Martin de Hijas, "Incidental acantholysis," Journal of Cutaneous Pathology, vol. ... Figure 4: Incidental focus of Hailey-Hailey-like acantholysis, occurring in association with a benign keratosis with features ... In the largest studies, incidental acantholysis was identified in 14 of 9000 specimens [35], and incidental FAD was identified ... Occasionally, these patterns are combined in a single specimen, and foci of acantholysis with overlapping histologic patterns ...
... acantholysis explanation free. What is acantholysis? Meaning of acantholysis medical term. What does acantholysis mean? ... Looking for online definition of acantholysis in the Medical Dictionary? ... acantholysis. Also found in: Dictionary, Thesaurus, Wikipedia.. Related to acantholysis: pemphigus, acanthosis, dyskeratosis, ... acantholysis. Splitting apart of layers of cells in the epidermis often top form a blister.. acantholysis. atrophy or ...
... Dermatit Grovera presence is original reaction of skin by astenised people, ...
acantholysis Reference type: Overview Page. Subject: Medicine and health, Dentistry. The breakdown of epidermal or epithelial ...
1988) Cantharidin-induced acantholysis. Am J Dermatopathol 10:419-423.. OpenUrlPubMed ...
Acantholysis: worth a second look?. Howard JC, Russell KJ, Vickers JL, Weiss E. ...
histology: without epidermal acantholysis. For the pemphigus group:. *patient with pemphigus. For the lupus group:. *systemic ...
Acantholysis is not prominent; however, it has been reported in older lesions. See the image below. ... Unlike pemphigus, a predominance of neutrophils and an absence or moderate acantholysis is observed; additionally, the ...
Paraneoplastic pemphigus acantholysis. . . . Investigations Serum electrolytes, glucose and bicarbonate are essential to assess ...
There is flaccid intraepidermal bullae caused by acantholysis; oral mucosa also involved. ...
Pemphigus vulgaris; Desmogleins; Acantholysis; Clinical pharmacist. Introduction. Phosphoribosylpyrophosphate synthetase-1 ( ...
Histologically, minimal or no apparent acantholysis is associated.] ...
In this variant of pemphigus, acantholysis selectively involves the layer of cells immediately above the basal cell layer, ... In this variant of pemphigus, acantholysis selectively involves the superficial epidermis at the level of the stratum ...
Biopsy reveals characteristic suprabasilar acantholysis and intraepidermal bullae formation. Immunofluorescence is similar to ...
Apoptosis is not required for acantholysis in pemphigus vulgaris.. Schmidt E, Gutberlet J, Siegmund D, Berg D, Wajant H, ...
Acantholysis is noted in the granular layer.. In nonbullous impetigo, a serum crust is present above the epidermis. Neutrophils ...
The Incidence of Acantholysis in Pityriasis Rubra Pilaris-Histopathological Study Using Multiple-Step Sections and ...
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  • Subtypes may include: Adenoid squamous cell carcinoma' (also known as "pseudoglandular squamous cell carcinoma"), characterized by a tubular microscopic pattern and keratinocyte acantholysis. (wikipedia.org)
  • At day 4pi, animals C1V1 and C2V2 had acanthosis, mild multifocal acantholysis and moderate focal hyperkeratosis, with focally extensive loss of epidermal layers (ulcer) and focally extensive necrosis with intralesional aggregate of basophilic coccoid bacteria (Figure 2A e 2C). (thefreedictionary.com)
  • The benign mucosa may show spongiosis, acantholysis , degeneration, and reactive atypia that mimic carcinoma or dysplasia. (thefreedictionary.com)
  • The term acantholysis refers to degeneration of the malpighian cells in which the intercellular fibrils diappear and the cells assume a spherical shape with swelling of the nuclei and condensation of the cytoplasm at the periphery. (hubpages.com)
  • But it has been unclear when and where apoptosis occurs with relation to acantholysis and to recognition of the junctions by antibodies generated by the immune system of the patient. (pemphigus.org)
  • A related viewpoint to the second is that the two occur simultaneously, though independently, though evidence exists for apoptosis actually causing acantholysis. (pemphigus.org)
  • According to the authors, conventional therapy of PV consisting of high-dose corticosteroids is based on the hypothesis that acantholysis leads to apoptosis, so it will be critical to unravel the current results and to determine if treatments might be tailored differently in the future. (pemphigus.org)
  • The results indicate that in different pemphigus patients, IgG-induced acantholysis proceeds predominantly via distinct, yet complementary, pathways of programmed cell death and that IVIg protect target cells by up-regulating endogenous caspase and calpain inhibitors. (uci.edu)
  • This graph shows the total number of publications written about "Acantholysis" by people in Harvard Catalyst Profiles by year, and whether "Acantholysis" was a major or minor topic of these publication. (harvard.edu)
  • A definitive diagnosis of PV is made when Nikolsky's sign is positive, in the presence of acantholysis in histopathology and by direct immunofluorescence . (thefreedictionary.com)
  • The disease is also characterized by slowly progressive and disfiguring reticulate hyperpigmentation of the flexures, clinically and histopathologically diagnostic for Dowling-Degos disease but also associated with suprabasal, nondyskeratotic acantholysis. (wikipedia.org)
  • This is an uncommon and rare histopathologic variant of SCC, characterised by acantholysis of the tumour cells, creating pseudo lumina and false appearance of glandular differentiation. (thefreedictionary.com)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)