Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.
Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.
A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS VULGARIS.
A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.
A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.
An autosomal dominantly inherited skin disorder characterized by recurrent eruptions of vesicles and BULLAE mainly on the neck, axillae, and groin. Mutations in the ATP2C1 gene (encoding the secretory pathway Ca2++/Mn2++ ATPase 1 (SPCA1)) cause this disease. It is clinically and histologically similar to DARIER DISEASE - both have abnormal, unstable DESMOSOMES between KERATINOCYTES and defective CALCIUM-TRANSPORTING ATPASES. It is unrelated to PEMPHIGUS VULGARIS though it closely resembles that disease.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
Visible accumulations of fluid within or beneath the epidermis.
A group of desmosomal cadherins with cytoplasmic tails that resemble those of classical CADHERINS.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic. (1/42)

Pemphigus vulgaris and pemphigus foliaceus are two closely related, but clinically and histologically distinct, autoimmune skin diseases. The autoantigens for pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively. The anti-desmoglein 1 antibodies in pemphigus foliaceus and anti-desmoglein 3 antibodies in pemphigus vulgaris are pathogenic as determined by immunoglobulin G passive transfer animal models. More than 50% of pemphigus vulgaris sera also contain anti-desmoglein 1 autoantibodies; however, the pathogenicity of the anti-desmoglein 1 autoantibodies in pemphigus vulgaris remains unknown. In this study, we used soluble recombinant extracellular domains of desmoglein 1 and desmoglein 3 to obtain affinity-purified anti-desmoglein 1 and anti-desmoglein 3 autoantibodies from pemphigus vulgaris sera and examined the pathogenicity of each fraction separately using the passive transfer mouse model. By immunoprecipitation, the purified anti-desmoglein 1 and anti-desmoglein 3 showed no cross-reactivity. The anti-desmoglein 1 autoantibodies in pemphigus vulgaris induced typical pemphigus foliaceus lesions in neonatal mice, whereas the anti-desmoglein 3 fraction induced pemphigus vulgaris-like lesions. In addition, the pathogenic anti-desmoglein 1 and anti-desmoglein 3 autoantibodies in pemphigus vulgaris had predominant IgG4 subclass specificity. These findings suggest that the anti-desmoglein 1 antibodies in pemphigus vulgaris are pathogenic.  (+info)

Immune modulation in pemphigus vulgaris: role of CD28 and IL-10. (2/42)

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease characterized by Abs to the desmosomal cadherin desmoglein-3. Although the autoantibodies have been shown to be pathogenic, the role of the cellular immune system in the pathology of pemphigus-induced acantholysis is unclear. To further delineate the potential role of T cell-signaling pathways in the pathogenesis of PV, we performed passive transfer experiments with PV IgG in gene-targeted mutant mice. Our results demonstrated that CD28-deficient mice (lacking a costimulatory signal for T cell activation) are 5-fold more sensitive to the development of PV than wild-type mice. To evaluate whether the higher incidence of disease was due to an impairment in intercellular adhesion of keratinocytes, we performed an in vitro acantholysis, using CD28-/- mice keratinocytes. No alteration in in vitro adhesion was detected in CD28-/--type keratinocytes. Because the CD28 molecule plays a pivotal role in the induction of Th2 cytokines, we examined the levels of a prototypic Th2 cytokine (IL-10) in CD28-/- mice. Lower levels of IL-10 mRNA were found in lesions from CD28-/- mice. To determine whether pemphigus susceptibility in CD28-/- was related to IL-10 deficiency, we performed passive transfer experiments in IL-10-/- mice that demonstrated increased blisters compared with controls. To confirm that IL-10 is involved in the pathogenesis, rIL-10 was given with PV IgG. IL-10 significantly suppressed the disease activity. These data suggest a potential role of IL-10 in PV.  (+info)

In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. (3/42)

Keratinocyte-derived cytokines have been implicated in the pathogenesis of a number of skin diseases. In this study we examined the possible role of keratinocyte-derived cytokines in the development of acantholysis in pemphigus vulgaris. Nineteen patients with pemphigus vulgaris, demonstrating the characteristic clinical, pathologic, and immunopathologic findings were studied. In situ immunolabeling demonstrated the presence of two cytokines interleukin-1alpha and tumor necrosis factor-alpha, in lesional and perilesional areas. Results were confirmed by reverse transcriptase-polymerase chain reaction, demonstrating overexpression of both cytokines in vivo. To study the role of these cytokines in the pathogenesis of pemphigus vulgaris both in vitro and in vivo studies were performed. The results of the in vitro study demonstrated that pemphigus vulgaris IgG induced interleukin-1alpha and tumor necrosis factor-alpha mRNA in the skin. The potential pathogenic role of these mediators was demonstrated by a blocking study using antibodies against human interleukin-1alpha and tumor necrosis factor-alpha in keratinocytes cultures. A combination of anti-interleukin-1alpha and anti-tumor necrosis factor-alpha antibodies inhibited in vitro pemphigus vulgaris IgG induced acantholysis. To confirm the role of interleukin-1 and tumor necrosis factor-alpha in pemphigus, we utilized passive transfer studies using interleukin-1 deficient mice (ICE-/-, interleukin-1beta-/-) and tumor necrosis factor-alpha receptor deficient mice (TNFR1R2-/-). Both groups demonstrated a decreased susceptibility to the passive transfer of pemphigus. Our data support the role of cytokines interleukin-1 and tumor necrosis factor-alpha in the pathogenesis of pemphigus vulgaris.  (+info)

Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. (4/42)

Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. It was assumed that PV is caused by anti-desmoglein (Dsg) 3 autoimmunity because absorption of PV sera with a chimeric baculoprotein containing the Dsg 3 and IgG1 portions, rDsg3-Ig-His, eliminated disease-causing antibodies. In this study we demonstrate that rDsg3-Ig-His adsorbs out autoantibodies to different keratinocyte antigens, including a non-Dsg 3 130-kd polypeptide. Because the pool of disease-causing PV IgGs contains antibodies against the keratinocyte acetylcholine receptor (AChR), we sought to identify the targeted receptor(s). Preincubation of monkey esophagus with PV antibodies blocked specific staining of the keratinocyte cell membrane with rabbit monoepitopic antibody to alpha9 AChR, indicating that this first of its kind AChR with dual, muscarinic and nicotinic pharmacology is targeted by PV autoimmunity. Anti-alpha9 antibody stained keratinocytes in a fishnet-like intercellular pattern, and visualized a single band at approximately 50 kd in Western blots of keratinocyte membrane proteins. Using step-by-step reverse transcription polymerase chain reactions with primers based on known alpha9 sequence regions, we identified the complete reading frame of human alpha9. Its amino acid sequence showed 85% similarity with rat alpha9. Treatment of keratinocyte monolayers with anti-alpha9 antibody induced pemphigus-like acantholysis, which could be reversed either spontaneously or by using the cholinergic agonist carbachol. We conclude that alpha9 is coupled to physiological regulation of keratinocyte adhesion, and its interaction with PV IgG may lead to blister development.  (+info)

Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. (5/42)

Pemphigus is an autoimmune disease of skin adhesion associated with autoantibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (Dsg) 1 and 3 and acetylcholine receptors. The notion that anti-Dsg antibodies alone are responsible for blisters in patients with pemphigus vulgaris (PV) stems from the ability of rDsg1 and rDsg3 to absorb antibodies that cause PV-like skin blisters in neonatal mice. Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. We injected into Dsg 3-lacking mice the PV IgGs that did not cross-react with the 160-kDa Dsg 1 or its 45-kDa immunoreactive fragment and that showed no reactivity with recombinant Dsg 1. We used both the Dsg3(null) mice with a targeted mutation of the Dsg3 gene and the "balding" Dsg3(bal)/Dsg3(bal) mice that carry a spontaneous null mutation in Dsg3. These PV IgGs caused gross skin blisters with PV-like suprabasal acantholysis and stained perilesional epidermis in a fishnet-like pattern, indicating that the PV phenotype can be induced without anti-Dsg 3 antibody. The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice. Therefore, mucocutaneous lesions in PV patients could be caused by non-Dsg antibodies.  (+info)

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris. (6/42)

Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes that is caused by anti-desmoglein 3 IgG autoantibodies. Recently, we generated an active disease mouse model for pemphigus vulgaris by adoptive transfer of splenocytes from immunized desmoglein 3-/- mice to Rag2-/- mice. In this study, we performed immunologic and histopathologic studies using this pemphigus vulgaris model in mice and compared the gross and microscopic phenotypes of pemphigus vulgaris model mice and desmoglein 3-/- mice. Pemphigus vulgaris model mice showed strong in vivo IgG, and weak IgA deposition on keratinocyte cell surfaces in stratified squamous epithelia, and produced circulating anti-desmoglein 3 IgG antibodies without apparent cross-reactivity to desmoglein 1, in enzyme-linked immunosorbent assays. The predominant IgG subclass was IgG1. Pemphigus vulgaris model mice and desmoglein 3-/- mice were almost indistinguishable in terms of both gross and microscopic findings. Both types of mice showed suprabasilar acantholysis in the stratified squamous epithelia, including the oral mucous membranes and traumatized skin around the snout or paws; however, some pemphigus vulgaris model mice demonstrated a more severe phenotype than desmoglein 3-/- mice. The esophagus and forestomach were affected in some pemphigus vulgaris model mice, but not in desmoglein 3-/- mice. Furthermore, eosinophilic spongiosis, which is found in early pemphigus vulgaris lesions in patients, was observed in pemphigus vulgaris model mice but not in desmoglein 3-/- mice. Pemphigus vulgaris model mice reflect several of the histopathologic and immunologic features seen in pemphigus vulgaris patients, and provide a valuable tool to investigate the pathophysiologic mechanisms of pemphigus vulgaris.  (+info)

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. (7/42)

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease that is caused by IgG autoantibodies against the cadherin-type adhesion molecule desmoglein (Dsg)3. Previously, we have generated an active mouse model for PV by adoptive transfer of Dsg3(-/-) splenocytes. In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation. Intraperitoneal inoculation of the AK23 hybridoma, but not the other AK hybridomas, induced the virtually identical phenotype to that of PV model mice or Dsg3(-/-) mice with typical histology of PV. Epitope mapping with domain-swapped and point-mutated Dsg1/Dsg3 molecules revealed that AK23 recognized a calcium-dependent conformational epitope on Dsg3, which consisted of the V3, K7, P8, and D59 Dsg3-specific residues that formed the adhesive interface between juxtaposed Dsg, as predicted by the crystal structure. The epitopes of the mAbs that failed to show apparent pathogenic activity were mapped in the middle to carboxyl-terminal extracellular region of Dsg3, where no direct intermolecular interaction was predicted. These findings demonstrate the pathogenic heterogeneity among anti-Dsg3 IgG Abs due to their epitopes, and suggest the direct inhibition of adhesive interaction of Dsg as an initial molecular event of blister formation in pemphigus.  (+info)

A case of focal acantholytic dyskeratosis occurring on both the lip and the anal canal. (8/42)

Focal acantholytic dyskeratosis has a distinctive histological pattern that is associated with various clinical expressions. It rarely occurs on the lip or the perianal area. We report a patient with focal acantholytic dyskeratosis occurring on both the upper lip and the anal canal. Histopathologically, the lesions showed hyperkeratosis, suprabasilar clefting, epidermal acantholysis and dyskeratosis. This case represents the first report of a focal acantholytic dyskeratosis occurring on both the lip and the anal canal.  (+info)

Grovers disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with or without dyskeratosis. Once confirmed, most cases of Grovers disease last six to twelve months, which is why it was originally called transient. However it may last much longer. Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis. Grovers disease often starts quite suddenly. There are intensely itchy spots on the central back, mid chest and occasionally elsewhere. Frequently, it follows sweating or some unexpected heat stress. The itchy eruption lasts an average of 10-12 months. It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs. The papules are most commonly found on the mid chest. Sometimes the features of Grovers are found in people who do not itch or have a conspicuous rash. Most of the people with Grovers who visit a dermatologist, however, itch a ...
ACANTHOLYSIS: Review the definition, meaning, pronunciation, explanation, synonyms, and antonyms of the term ACANTHOLYSIS in the Online Dictionary. What is a 12 letter word that starts with A?
Transient acantholytic dermatosis is more commonly referred to as Grover disease. In 1970 Grover described a pruritic transient eruption in persons older than age 50 years. Although this condition is benign and eventually self-limiting, the rash tends to be persistent and recurrent for months to a few years. For this reason, several authors suggest renaming the condition persistent and recurrent acantholytic dermatosis.1 The middle-aged and senior population is most commonly affected. In addition, whites appear to be affected at a significantly higher rate. Incidence is slightly greater in men than in women. Clinical findings in Grover disease typically consist of numerous discrete 3- to 5-mm red, pink, or brown papules, papulovesicles, and erosions. On palpation, lesions may appear to be hyperkeratotic or verrucous. Although the central trunk is affected most often, lesions may infrequently be found on the proximal extremities. The palms, soles, and scalp are almost always spared. Pruritus, ...
Complete information for ASCC2 gene (Protein Coding), Activating Signal Cointegrator 1 Complex Subunit 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The American Society of Concrete Contractors (ASCC) published Troubleshooting Newsletter #58 that provides solutions to problems encountered by ASCC members and answered by the ASCC Technical Hotline. The newsletter published selected hotline questions with answers and citations for ACI documents for more information. Topics covered in the newsletter include measuring floor flatness and levelness after […]
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Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Background Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. Description ASCC1 Polyclonal...
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Cancer Therapy Advisor provides dermatologists with the latest dermatology conditions, procedures and guides for different surgical and non surgical conditions. Visit often for updates and new information.
TY - JOUR. T1 - (3) Calcium enhances the sensitivity of immunofluorescence for pemphigus antibodies. AU - Matis, W. L.. AU - Anhalt, Grant James. AU - Diaz, L. A.. AU - Rivitti, E. A.. AU - Martins, C. R.. AU - Berger, Robert. PY - 1988. Y1 - 1988. UR - http://www.scopus.com/inward/record.url?scp=84988103834&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84988103834&partnerID=8YFLogxK. U2 - 10.1111/j.1365-2133.1988.tb05377.x. DO - 10.1111/j.1365-2133.1988.tb05377.x. M3 - Article. AN - SCOPUS:84988103834. VL - 119. SP - 42. JO - British Journal of Dermatology. JF - British Journal of Dermatology. SN - 0007-0963. ER - ...
AFX is a superficial fibrohistiocytic tumor that presents on the head and neck of elderly patients and is usually a pink or red, solitary, firm, asymptomatic papule or nodule.2,3 Histologically, AFX reveals a dermal proliferation of spindle and epithelioid cells with (often marked) pleomorphism, bizarre mitotic figures, and multinucleated cells.3 There are many variants of AFX, including spindle cell nonpleomorphic, clear cell, osteoclastic, and granular cell.3 Cutaneous squamous cell carcinoma (SCC) has a very diverse range of clinical and pathological subtypes including, but not limited to, acantholytic poorly differentiated and spindle cell.4 A patient with a forehead lesion containing both an SCCis arising within the wall of a trichilemmal cyst and surrounding AFX has been previously reported.1 AFX and SCC occurring together on the conjunctiva5 and face6 of patients with xeroderma pigmentosum have also been reported. It is not surprising to observe a collision of SCCis (or SCC) and AFX ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result
By Professor Martin M Black, MD. Pemphigus and its variants are rare autoimmune disorders characterized by loss of cell to cell cohesion between keratinocytes leading to intra-epidermal blistering. In all types of pemphigus, antibodies are directed against antigens in the intercellular substance between keratinocytes and in a substantial number of active cases, these pemphigus antibodies can be detected in the general blood circulation.. Pempigus vulgaris (PV) is characterized by flaccid blistering and erosions of the skin and mucous membranes. Involvement within the mouth may often precede the skin erosions and may persist even long after skin lesions subside. It is therefore important to remember that involvement of the oral cavity may take the patient to see dental surgeon, rather than a dermatologist in the first instance. However, in pemphigus foliaceus (PF) the blistering tends to be more superficial than in the vulgaris form of pemphigus and the mucous membrane areas are not ...
The first contribution to the chapter will require editorial approval before being published. Only high quality extensive reviews will be approved for initial publication.. Publishing on Dermpedia is easy. If you already have suitable content on file, it will not take much more than cut and paste to publish it on Dermpedia. Please see help for instructions. Dermpedia is designed to be user-editable, but yes, if you have great content, would like to become the Editor of this page, but have not time to edit this page, we will find helpers to publish it for you.. Registration is required.. Adding Cases and Images. You can add cases to book pages and either add images directly or attached to cases (preferred).. Add a case: Click on the Add a case link while on the book page and you will be asked to create a new case by filling in the necessary fields and pressing submit. Once youve done that, there is the further opportunity to add images to the case.. Add an image: Click on the Add an image ...
ASCC Student ID Card Fee The Student ID Card provides a college picture ID for use in campus labs, the library, the bookstore, and other locations on campus. It helps fund student jobs, student activities, critical campus programs and services, as well as providing discounts within the community. For more information about the ASCC card, see ASCC Student ID Card. This optional fee is nonrefundable once the semester begins. The ASCC card fee is not an eligible tax credit fee. The ASCC Student ID Card is to be purchases/renewed each semester, even if a student has already had her or his picture taken.. If the ASCC Student ID Card is lost, stolen, or mutilated, the student will be provided, free of charge, one replacement during the students Cuesta career. For any additional cards there is a $2 replacement fee. Contact the Student Life and Leadership Office at (805) 546-3289 for picture ID dates, times, and information.. Student Representation Fee A vote of the students during the Spring 2002 ...
In mammalian tissues, uptake of Ca(2+) and Mn(2+) by Golgi membranes is mediated by the secretory pathway Ca(2+) -ATPases, SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes. Loss of one copy of the ATP2C1 gene, which causes SPCA1 haploinsufficiency, leads to squamous cell tumors of keratinized epithelia in mice and to Hailey-Hailey disease, an acantholytic skin disease, in humans. Although the disease phenotypes resulting from SPCA1 haploinsufficiency in mice and humans are quite different, each species-specific phenotype is remarkably similar to those arising as a result of null mutations in one copy of the ATP2A2 gene, encoding SERCA2, the endoplasmic reticulum (ER) Ca(2+) pump ...
Insights from a desmoplakin mutation identified in lethal acantholytic epidermolysis bullosa.. J Invest Dermatol. 2010 Nov;130(11):2680-3. Authors: Hobbs RP, Han SY, van der Zwaag PA, Bolling MC, Jongbloed JD, Jonkman MF, Getsios S, Paller AS, Green KJ. PMID: 20613772 [PubMed - indexed for MEDLINE]. ...
Histologic examination revealed intraepidermal vesicles containing acantholytic cells and ulceration. There was ballooning degeneration of keratinocytes. Also,
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The Access, Security & Confidentiality Committee (ASCC) recommends provincial best practices and guidelines associated with the collection, access, use, protection security, and disclosure of .... ...
1LWN: Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
TY - JOUR. T1 - Unusual presentation of pemphigus vulgaris. AU - Bardazzi, F.. AU - Guerra, L.. AU - Peluso, A. M.. AU - Piraccini, B. M.. AU - Morelli, R.. PY - 1994. Y1 - 1994. N2 - We report a case of a 50-year-old man who presented with a conjunctival erosion and lesions resembling acute paronychia of several fingers. The Tzanck preparation from the conjunctiva showed the presence of acantholytic cells. Skin biopsy showed suprabasal cleft formation with acantholysis. Direct immunofluorescence revealed intercellular epidermal staining with IgG and C3. Diagnosis of pemphigus vulgaris was therefore confirmed. Nail abnormalities that can be observed in pemphigus vulgaris are discussed.. AB - We report a case of a 50-year-old man who presented with a conjunctival erosion and lesions resembling acute paronychia of several fingers. The Tzanck preparation from the conjunctiva showed the presence of acantholytic cells. Skin biopsy showed suprabasal cleft formation with acantholysis. Direct ...
Define pemphigus vulgaris. pemphigus vulgaris synonyms, pemphigus vulgaris pronunciation, pemphigus vulgaris translation, English dictionary definition of pemphigus vulgaris. n. Any of several acute or chronic skin diseases characterized by groups of itching blisters. pem′phi·gous adj. n pathol any of a group of blistering skin...
RESULTS: Of the 72 patients, 63 (88%) were men, and the mean age was 48 years (range, 31 to 85). Lesions were distributed mainly on the trunk (in 71 patients) and proximal extremities (in 25). Heat and sweating frequently were exacerbating factors. Fifteen patients (21%) were bedbound. Concurrent nondermatologic malignant disease was present in 18 patients (25%). Two patients (3%) had acquired immunodeficiency syndrome. Follow-up in 28 patients (mean, 38 months; range, 3 months to 7 years) revealed that the disease had recurred in 13, persisted in 3, and resolved in 12. Review of the biopsy specimens showed that acantholysis was pemphigus vulgaris-like in 40 patients (56%), Dariers disease-like in 16 (22%), spongiotic in 12 (17%), pemphigus foliaceus-like in 2 (3%), and Hailey-Hailey disease-like in 2 (3%). A perivascular lymphocytic infiltrate of varied intensity in 64 specimens (89%) was associated with eosinophils in 16 (22%). In nine biopsy specimens with dermal eosinophilia stained for ...
The American Samoa Community College (ASCC) will hold its 67th commencement ceremony on Friday, December 15th, at 10 a.m. in the Colleges gymnasium. Governor Lolo M. Moliga and other dignitaries have been invited to join this semesters celebration of the young men and women who have completed their degrees and certificates, including three students who have earned their Bachelor in Education (BEd) diplomas. A preliminary count of 103 ASCC graduates will celebrate an important milestone in their lives, though the actual number may change depending on examination results or other factors.. As always, the College has sought out a distinguished member of the community to offer words of congratulations and encouragement to the graduates. ASCC alumnus William Ena Spitzenberg may not be as well-known as some of the previous speakers, but he has traveled far, made advancements within his chosen career, and has now returned home to contribute to the betterment of his home, just as many young American ...
Anal Squamous Cell Carcinoma (ASCC) is an uncommon cancer with an incidence rate between 1 and 2 per 100000 per year. However, the incidence of ASCC is increasing rapidly, with up to 6.8% increase in men per year and 10.7% increase in women per year since 1971.. It is believed that the increasing numbers of HIV positive patients who are living longer on advanced antiretrovirals are likely to be contributing to the increasing burden of ASCC. Anal Intraepithelial Neoplasia (AIN) is the known precursor to ASCC. It is believed that by identifying and treating high grade AIN that ASCC could become a preventable cancer. ASCC also has excellent outcomes if identified early. Only 15% of ASCC present with metastasis and most patients are diagnosed with resectable T1 tumours. However, current guidelines are conflicting and not based on good quality clinical evidence, The limiting factor to providing good quality evidence is the large samples size required to observe the relationship between AIN ...
What are the aims of this leaflet?. This leaflet has been written to help you understand more about Dariers disease. It tells you what it is, what causes it and what can be done about it including treatment options. It provides other sources where you can find out more information about it.. What is Darier disease?. It is a rare inherited skin condition, estimated to affect 1 to 4 people per 100,000 of the population and is characterised by a change in the way skin cells (keratinocytes) stick together within the upper layer of the skin (epidermis). This leads to changes in the skin and nails, and sometimes inside the mouth can be affected. Other names for Darier disease include Darier-White disease and Keratosis Follicularis.. What causes Darier disease?. The movement of calcium within cells is disrupted, leading to a change in the way skin cells are held together. Normally, these cells are held together like bricks cemented in a wall. In Darier disease, the cement that holds the skin cells ...
It isnt often that a high level official such as the Director of the National Oceanic and Atmospheric Administration (NOAA) Office of the National Marine Sanctuaries (ONMS) travels to American Samoa and makes time to speak with college students.. The American Samoa Community College (ASCC) was honored to have Mr. John Armor, Director of ONMS, spend an hour talking with ASCC Marine Science Program and Agriculture, Community and Natural Resource (ACNR)/Land Grant students on March 31st.. Armor spoke about how he fell in love with the ocean at a young age, and how he persevered throughout his career to ultimately end up where he is today, as the Director of the entire National Marine Sanctuary program.. He recounted the hard work he put into seeking out opportunities in his field of interest, and how important it is to not be discouraged if you arent accepted to your first, second, or even third attempts to get a job or an internship.. Armor shared how his first marine internship after college ...
Kirov State Medical University. The article describes modern views on predisposing factors, characteristics of the immunological changes and link with the histocompatibility antigens HLA, the role of circulating autoantibodies in the pathogenesis of the disease in patients with pemphigus vulgaris. Described 2 cases of clinical observations and vulgar pemphigus, foliaceous pemphigus, accompanied by concomitant pathology of internal organs in the form of cardiovascular system pathology, chronic iron deficiency anemia, diffuse and knotty changes of the thyroid gland. The good effect of etiotropic, pathogenetic and symptomatic therapy in accordance with the standards of specialized medical care in moderate-to-severe pemphigus. ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
Javier Rangel, MD Perm J 2016 Winter; 20(1):e101-e102 http://dx.doi.org/10.7812/TPP/15-059 Abstract The development of pemphigus, including
Looking for information on Dog Pemphigus in Fargo? We have compiled a list of businesses and services around Fargo that should help you with your search. We hope this page helps you find information on Dog Pemphigus in Fargo.
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Santa, Mrs. Claus and the Hoisington Chamber of Commerce staff agree, tonight is not a great night for be out and about. So, they are rescheduling the Christmas Lighting celebration to Tuesday, Dec. 8. The city lights will still be turning on tonight, but plan to come up to the Chamber and Santa House on Dec. 8 to see Santa and Mrs. Claus, enjoy cocoa and cookies and sign up for Chamber Gift Certificates and the 50/50 Winter raffle. ...
Risks for Pemphigus foliaceus, Pemphigus foliaceus treatments, recommended products for Pemphigus foliaceus, ways to prevent Pemphigus foliaceus, causes of Pemphigus foliaceus
TY - JOUR. T1 - Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. AU - Kamiya, K.. AU - Aoyama, Y.. AU - Yamasaki, O.. AU - Kamata, A.. AU - Yamagami, Jun. AU - Iwatsuki, K.. AU - Tokura, Y.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Background Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are closely related, but clinically distinct, autoimmune blistering diseases caused by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. Using ethylenediaminetetraacetic acid (EDTA)-treated Dsg3 enzyme-linked immunosorbent assay (ELISA) we have shown that the proportion of anti-Dsg3 antibodies against calcium-dependent epitopes decreased upon shifting to the inactive phase in patients with PV. Objectives To analyse the epitope profiles of anti-Dsg1 antibodies across the different activity stages of PF. Methods We evaluated five patients with PF who retained high serum levels of anti-Dsg1 antibodies in the inactive phase. ...
HAILEY-HAILEY DISEASE. What are the aims of this leaflet?. This leaflet has been written to help you understand more about Hailey-Hailey disease. It tells you what it is, what causes it, what can be done about it, and where you can find out more about it.. What is Hailey-Hailey disease?. Hailey-Hailey disease is also known as familial benign chronic pemphigus, as originally described by the Hailey brothers. It is a rare inherited skin condition in which red scaly areas that can be itchy and sore, can lead to superficial blisters and eroded (broken) areas of the skin folds of the groin, armpits, neck and under the breasts. The condition flares intermittently and tends to come and go. Many patients are able to lead full and normal lives, with their condition being a nuisance rather than a serious problem. Some patients are more severely affected and experience more persistent painful raw areas of the skin with development of superficial blisters.. What causes Hailey-Hailey disease?. A small error ...
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a com
What is Pemphigus Vulgaris or Skin & mouth Blisters? Get treatment for blisters on Skin & in Mouth. The Esthetic Clinic provides the best in class treatment for Pemphigus Vulgaris or Skin & mouth Blisters in Mumbai and India. Best Dermatologist for skin diseases, Contact details - [email protected] or +91-9004671379
Desmoglein 3 antibody [3G133] (desmoglein 3) for ICC/IF, IHC-P, IP, WB. Anti-Desmoglein 3 mAb (GTX14416) is tested in Human samples. 100% Ab-Assurance.
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Pemphigus foliaceus is a rare autoimmune disorder that causes people to have skin that blisters easily and develops crusty, scaly...
Pemphigus Vulgaris is mainly characterized by a formation of blisters in the mouth which make it difficult to swallow food or drink water. These blisters later
Polyclonal antibody for Desmoglein 3/DSG3 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Desmoglein 3/DSG3 information: Molecular Weight: 107533 MW; Subcellular Localization: Cell membrane ; Single-pass type I
Familial benign pemphigus pathology, Hailey-Hailey disease pathology, Familial benign chronic pemphigus pathology, MIM 169600 pathology. Authoritative facts from DermNet New Zealand.
尋常性天疱瘡に検出されるデスモグレイン3のカルシウム非依存性構造に対する抗体とその病因性への関 ...
Rabbit recombinant monoclonal Desmoglein 1 antibody [EPR6766(B)] validated for WB, IHC and tested in Human, Mouse and Rat. Referenced in 1 publication and 4…
The rest of December went well, eye healing up and skin was getting better. After the surgery Otis started to gain weight and muscle. I think the eye was bothering him for much longer than we knew. Somewhere in the back of my mind I crossed my fingers that the tumor had caused all of…
This weeks colors are B24, G24 and Y21 and any other green. As with all Kimms Copic Challenges, you can use 1,2 or all 3 of her color suggestions (or something close). The names of the colors really grabbed me - Sky, Willow, and Buttercup Yellow! These enticing descriptors got me thinking about the summer fields and open sky. Looking around my craft area, I realized I had just enough (formerly) 12 x 12 cardstock to make one last Triple Play card, a Technique Junkie idea that makes a card that fits in a regular #10 envelope. That got me thinking about snail mail...and well the rest is history! ...
Argenx discovers, designs and develops innovative antibody therapeutics for its own pipeline of treatments for cancer and autoimmune diseases and for its partners. Harnessing our technology and know-how, we aim to meet the needs of patients by engineering antibodies to target diseases too complex for other antibody technologies.
This rare autoimmune disorder caused a womans vulva to swell up and break out in blisters. We spoke to a dermatologist to find out how that happens.
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
TY - JOUR. T1 - Pemfigo radioindotto con ritardo diagnostico. AU - Hendrickx, I.. AU - Guizzardi, M.. AU - Mancini, L. L.. AU - Monti, M.. PY - 1999. Y1 - 1999. N2 - Ionizing radiation-induced pemphigus is a rare reported clinical entity, arising after a radiation therapy that usually follows surgical treatment for malignancy. A case of ionizing radiation-induced pemphigus arised after X-ray therapy for mammary carcinoma is reported. After two weeks of X-ray delivery, erythema and erosions appeared on the radiated area. These lesions were interpreted as an inflammatory result of radiation and cured. After eighteen months, typical pemphigus bullous eruptions developed all over the body and oral mucosa. The importance of considering ionizing radiation-induced pemphigus among the attending side effects of radiotherapy is underlined and it is suggested to submit to dermatological attention every case of uncertain skin reaction.. AB - Ionizing radiation-induced pemphigus is a rare reported clinical ...
Background: Pemphigus is a rare, autoimmune blistering condition, resulting in significant morbidity and mortality. It warrants treatment by various immunosuppressive age..
I have just been diagnosed with Pemphigus. I dont know what to expect. I see my doctor on Friday for the first time. I am always tired. Is this a symptom of...
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Seshadri, Divya (2013). "Acantholysis revisited: Back to basics". Indian J Dermatol Venereol Leprol. 79 (1): 120-6. doi:10.4103 ...
The process leads to the loss of cellular connections (acantholysis) and ultimately blistering of the skin. Lesions heal ... Bertaux, B.; Prost, C.; Heslan, M.; Dubertret, L. (1988). "Cantharide acantholysis: endogenous protease activation leading to ...
This in turn causes a loss of adhesion with acantholysis as a result. The National Institute of Arthritis and Musculoskeletal ...
In addition to blistering, other symptoms which accompany HHD include acantholysis, erythema and hyperkeratosis. The cause of ... causing acantholysis, blisters and rashes. There is no known cure.[citation needed] While the term pemphigus typically refers ...
The pathologist looks for an intraepidermal vesicle caused by the breaking apart of epidermal cells (acantholysis). Thus, the ... a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these blisters can ... and acantholysis. The least common and most severe type of pemphigus is paraneoplastic pemphigus (PNP). This disorder is a ... acantholysis), and by the presence of pathogenic (predominantly IgG) autoantibodies reacting against epithelial adhesion ...
... and acantholysis.: 465 Early descriptions were made by Darrell Wilkinson, a British dermatologist. Pemphigus List of cutaneous ...
PV is manifested by suprabasal acantholysis, or blisters in the mucous membrane and blisters in the epidermis. PF patients have ...
These blisters are due to acantholysis, or breaking apart of intercellular connections through an autoantibody-mediated ...
This results from the disruption of tonofilaments in the desmosomes with acantholysis and intra-epidermal blister formation. " ...
Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis: 529 ...
... are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". The Journal ...
... is characterized by a tubular microscopic pattern and keratinocyte acantholysis. Basaloid squamous cell carcinoma is ...
... pemphigoid does not feature acantholysis, a loss of connections between skin cells. Pemphigoid is more common than pemphigus, ...
... nondyskeratotic acantholysis. List of cutaneous conditions Skin lesion James, William; Berger, Timothy; Elston, Dirk Andrews' ...
... epidermal acantholysis (breaking apart of the skin), dyskeratotic keratinocytes and vacuolar changes in the layers of the skin ... Histologic evidence of acantholysis (loss of intercellular connections leading to breaking apart of the skin; lesion) Direct ...
Poikiloderma Hyperkeratosis Parakeratosis Hypergranulosis Acanthosis Papillomatosis Dyskeratosis Acantholysis Spongiosis ...
... acantholysis MeSH C17.800.865.187 - blister MeSH C17.800.865.360 - dermatitis herpetiformis MeSH C17.800.865.385 - eczema, ...
... is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes ... ISBN 0-7216-0187-1. "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Archived from the original on 2016- ...
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes ... ISBN 0-7216-0187-1. "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Archived from the original on 2016- ...
Pemphigus occurring at tuberculin injection site: Role of cytokines in acantholysis.. Authors: Keshavamurthy, Vinay. Kanwar, ... Role of cytokines in acantholysis. Indian Journal of Dermatology, Venereology and Leprology. 2013 Jul-Aug; 79(4): 539-541. ...
Acantholysis, positive DIF. Antibody-mediated and cell-mediated autoimmunity. LABD, drug induced. Recent initiation of ...
Acantholysis is usually absent.. Confirming a diagnosis of paraneoplastic NME is achieved by performing specific laboratory ...
Yamamoto T. Incidental acantholysis of the overlying epidermis of dermatofibroma. J Eur Acad Dermatol Venereol. 2009 Jun. 23(6 ...
Several hypotheses for the mechanisms of acantholysis induction by PV-IgG exist, but the actual mechanism is not clear as yet. ... Several hypotheses for the mechanisms of acantholysis induction by PV-IgG exist, but the actual mechanism is not clear as yet. ... Several hypotheses for the mechanisms of acantholysis induction by PV-IgG exist, but the actual mechanism is not clear as yet. ... Several hypotheses for the mechanisms of acantholysis induction by PV-IgG exist, but the actual mechanism is not clear as yet. ...
... acantholysis). Acantholysis can cause skin irritation and itchiness and lead to reddened or missing patches of skin (erosions ...
bullous autoimmune dz; IgG Ab =, acantholysis =, loss of cell-cell adhesion. pemphigus vulgaris S/S. oral mucosa lesions ...
Acantholysis has been reported as an additional histologic finding in pityriasis rubra pilaris. [9] Acantholysis may be ... Howe K, Foresman P, Griffin T, Johnson W. Pityriasis rubra pilaris with acantholysis. J Cutan Pathol. 1996 Jun. 23(3):270-4. [ ... The presence of acantholysis, hypergranulosis, follicular plugging, and the absence of dilated capillaries and epidermal ... Avitan-Hersh E, Bergman R. The Incidence of Acantholysis in Pityriasis Rubra Pilaris-Histopathological Study Using Multiple- ...
Acantholysis: loss of appropriate keratinocyte cell-cell contact (pemphigus, transient acantholytic dermatosis, Hailey-Hailey, ... Presence or absence of acantholysis * Characterization of any associated inflammatory infiltrate * Immunofluorescent pattern * ... Large intraepidermal bullae without acantholysis may represent healed subepidermal bullae (re-epitheliazation phenomemon) * ...
Acantholysis. Separation and rounding up of keratinocytes because of loss of intercellular adhesions. ...
Acantholysis. Very frequent [Orphanet] 11 / 7739 5. (HPO:0200042) Skin ulcer. Very frequent [Orphanet] 138 / 7739 ...
Lesions resembling pemphigus foliaceus reveal superficial epidermal acantholysis, while those resembling pemphigus vulgaris ... reveal suprabasal acantholysis. Eosinophilic spongiosis may be present. It is not possible to distinguish between idiopathic ...
... is a skin autoimmune blistering disease due to acantholysis, the loss of adhesion... ... Endemic pemphigus foliaceus (PF), also known as fogo selvagem, is a skin autoimmune blistering disease due to acantholysis, the ...
Follicular acantholysis may also be a subtle histologic manifestation of PV, as reported by Mahalingam. [4] This observation of ... Mahalingam M. Follicular acantholysis: a subtle clue to the early diagnosis of pemphigus vulgaris. Am J Dermatopathol 2005;27: ... 3] The presence of Dsg3 in the hair follicle epithelium would explain the presence of acantholysis in the adnexal epithelium in ... The biopsy specimen from all these cases showed typical microscopic features of PV, such as suprabasal bulla, acantholysis and ...
This condition is histologically variable, and the key finding on pathology is focal acantholysis. The disease can be self- ...
The biopsy demonstrates suprabasilar acantholysis, which means that there is a split within the epidermis above the basal ...
... and hailey-hailey-like acantholysis: a potential marker of premalignant skin change ...
... with squamous differentiation and focal areas of acantholysis. ...
Figure 3:: Acantholysis and dyskeratosis with the presence of corps ronds and grains (H and E, ×400) ... Figure 2:: Acantholysis throughout the epidermis, hyperkeratosis, and parakeratosis were found in the epidermis with chronic ... The histologic features of papular acantholytic dyskeratosis are acantholysis which may involve the full thickness of the ... The histopathologic findings showed acantholysis throughout the epidermis with dyskeratotic cells resembling corps ronds and ...
Acantholysis may sometimes be observed in the matrix or nail bed.16 ...
Intraepidermal Acantholysis. Fluid Loss. Infection. Nikolsky Positive. Diagnosis. Biopsy showing Autoantibodies. Treatment. ...
Acantholytic actinic keratosis: In this condition there is prominent atypia of the keratinocytes, with acantholysis frequently ... Pemphigus vulgaris: In this related condition intraepidermal acantholysis is seen within the lower suprabasal epidermis, with ...
Intraepidermal vesicle produced by profound degeneration of epidermal cells, resulting in marked acantholysis. ...
Familial acantholysis (disorder). Code System Preferred Concept Name. Familial acantholysis (disorder). Concept Status. ...
  • Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. (wikipedia.org)
  • Endemic pemphigus foliaceus (PF), also known as fogo selvagem, is a skin autoimmune blistering disease due to acantholysis, the loss of adhesion among keratinocytes. (bartleby.com)
  • The biopsy demonstrates suprabasilar acantholysis, which means that there is a split within the epidermis above the basal keratinocytes. (clinicaladvisor.com)
  • In this condition there is prominent atypia of the keratinocytes , with acantholysis frequently present through all layers of the involved epidermis. (dermnetnz.org)
  • Their impaired biological function leads to loss of adhesion, acantholysis and apoptosis of keratinocytes. (altmeyers.org)
  • Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by acantholysis of keratinocytes due to pathogenic desmoglein-3 autoantibodies. (biomedcentral.com)
  • Autoantibodies against the desmosomal component desmoglein-3 are implicated in acantholysis of keratinocytes, leading to formation of clefts or bullae [ 1 ]. (biomedcentral.com)
  • The molecular background of the blistering is the interference of the adhesion between the keratinocytes (acantholysis) by the autoantibodies against intercellular adhesion structures. (svarlifescience.com)
  • Due to the decrease in the active SERCA2 protein, the affected keratinocytes cannot conduct normal Ca metabolism and result in the individual dyskeratosis and acantholysis. (nii.ac.jp)
  • The term 'epidermal necrolysis' (EN) is used in this article to describe the spectrum of disease that includes SJS and TEN. (medscape.com)
  • [ 1 ] They are simply described together as epidermal necrolysis (EN). (medscape.com)
  • Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. (tau.ac.il)
  • We have previously reported on apoptosis induction in PV-IgG-mediated epidermal tissue and cell damage as a possible mechanism of acantholysis and cell death (Wang et al. (tau.ac.il)
  • The presence of acantholysis, hypergranulosis, follicular plugging, and the absence of dilated capillaries and epidermal pustulation may help distinguish pityriasis rubra pilaris from psoriasis. (medscape.com)
  • Lesions resembling pemphigus foliaceus reveal superficial epidermal acantholysis, while those resembling pemphigus vulgaris reveal suprabasal acantholysis. (medscape.com)
  • Loss of epidermal cohesion in normal skin explants incubated with pemphigus foliaceous IgG was dependent upon the addition of plasminogen and was inhibited by aprotinin or lima bean trypsin inhibitor, which indicated that plasmin is the active enzyme in producing acantholysis. (cdc.gov)
  • Intraepidermal vesicle produced by profound degeneration of epidermal cells, resulting in marked acantholysis. (dermpathdiagnostics.com)
  • Both models demonstrated a similar timecourse of sunburn cell (SBC) formation, epidermal necrosis, acantholysis and parakeratosis, and regeneration. (mattek.com)
  • This condition is histologically variable, and the key finding on pathology is focal acantholysis. (logicalimages.com)
  • Warty dyskeratoma (WD) is an uncommon skin tumor that histologically presents as focal acantholysis and dyskeratosis and is a common finding among acantholytic diseases such as Darier's disease. (bvsalud.org)
  • Histologically, subcorneal acantholysis and bulla formation are seen. (pathos223.com)
  • Would show subcorneal pustules with neutrophils and acantholysis. (partishpresademokrate.com)
  • b) Histology of the skin shows subcorneal acantholysis and blister filled with neutrophils. (medicalkidnap.com)
  • Histopathology reveals acantholysis with varying degrees of dyskeratosis, and direct and indirect immunofluorescence are negative in almost all cases studied. (actasdermo.org)
  • Histopathology confirms acantholysis, and keeping pores and noninflammatory and why we caution in dosage forms. (gors.nl)
  • Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS. (lookformedical.com)
  • It is characterized by intraepidermal bullae with neutrophils, some acantholysis and eosinophils. (alwaysayurveda.net)
  • The acantholytic effect caused by PV-IgG binding to cell surface receptors begins with and depends on cell surface receptor (EGFR) activation of intracellular signaling pathways (ERK pathway) and apoptosis induction (FasR pathway), which later lead to major cell-cell separation (acantholysis) and cell death. (tau.ac.il)
  • c) completion angiogram after removal of the pinna (fig. Streptococcus pneumoniae and the incision and surrounding skindemonstrate acantholysis (separation of the bone and the, in newborns. (berea.edu)
  • In this related condition intraepidermal acantholysis is seen within the lower suprabasal epidermis, with matching direct immunofluorescence at this level. (dermnetnz.org)
  • The specific tyrosine kinase inhibitor AG1478 abrogated EGFR autophosphorylation, cell death, FasL appearance and acantholysis, all induced by PV-IgG, in parallel, confirming the involvement of EGFR in this Fas apoptotic cascade. (tau.ac.il)
  • In addition to pigmentation changes, individuals with Galli-Galli disease also have a breakdown of cells in the outer layer of skin (acantholysis). (medlineplus.gov)
  • Background: Pemphigus vulgaris (PV) is an autoimmune disease characterized by acantholysis. (bezmialem.edu.tr)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • It was previously believed that widespread keratinocyte death in EN is predominantly mediated by soluble Fas-ligand and that intravenous immunoglobulin therapy is useful in blocking this mechanism with resultant survival benefits. (medscape.com)
  • Several hypotheses for the mechanisms of acantholysis induction by PV-IgG exist, but the actual mechanism is not clear as yet. (tau.ac.il)
  • The mechanism by which mutant ATPC1 causes acantholysis is unknown, but it may be through abnormally elevated cytoplasmic calcium or abnormally low Golgi Ca(2+) levels. (haileyhailey.com)
  • Acantholysis can cause skin irritation and itchiness and lead to reddened or missing patches of skin (erosions). (medlineplus.gov)
  • IMSEAR at SEARO: Pemphigus occurring at tuberculin injection site: Role of cytokines in acantholysis. (who.int)
  • Keshavamurthy Vinay, Kanwar Amrinder J, Saikia Uma N. Pemphigus occurring at tuberculin injection site: Role of cytokines in acantholysis. (who.int)
  • Superficial pustular dermatosis with acantholysis in a Limousin calf. (bsvp.org)
  • A diagnosis of Superficial pustular dermatosis with acantholysis was made. (bsvp.org)
  • A punch biopsy of the right abdomen was performed and revealed psoriasiform epidermal hyperplasia, focal parakeratosis, and acantholysis throughout the superficial spinous and granular layers (Figure 3). (skinofcolorupdate.com)
  • A congenital defect leading to acantholysis seems probable in this calf, though the expression appears milder than in the inherited conditions described. (bsvp.org)
  • DSP missense variant in a Scottish Highland calf with congenital ichthyosis, alopecia, acantholysis of the tongue and corneal defects. (unibe.ch)
  • The epidermis showed mild and diffuse spongiosis with focal exocytosis of neutrophils without acantholysis. (cdlib.org)
  • Sometimes it showed spongiosis, but the acantholysis was frequently very prominent. (bsvp.org)
  • Typical epithelial lesions include hyperkeratosis (increased thickness of the keratin layer), acanthosis (increased thickness of the prickle cell layer with or without associated hyperkeratosis), atrophy (thinning of the epithelium, often associated with incomplete keratinization), or acantholysis (loss of the intercellular attachments in the prickle cell layer leading to separation of the cells). (antimicrobe.org)
  • The key to diagnosing SPD is a biopsy demonstrating a sterile subcorneal pustule filled with neutrophils, absence of acantholysis, and negative immunofluorescence. (cdlib.org)
  • Acantholysis is a feature of some autoimmune disease processes such as pemphigus foliaceus but in an individual of this age, an autoimmune process was unlikely. (bsvp.org)
  • Histologic assessment of the lesion identified acanthosis and acantholysis with dermal eosinophils consistent with pemphigus vegetans. (jofskin.org)
  • PEMPHIGUS vulgaris is a severe and often fatal blistering disease, affecting the skin and mucous membranes, in which intraepithelial vesicles form as a result of a distinctive process of cell detachment termed acantholysis. (elsevier.com)
  • Inherited disease characterised by acantholysis due to defective epithelial adhesion is also described in humans and dogs. (bsvp.org)
  • The histologic picture in dogs and in the Angus calves would appear to show a more extensive pattern of acantholysis than is present in this individual. (bsvp.org)
  • b) Histologic findings that reflect the variability of the cutaneous lesions, showing acantholysis, lichenoid, or interface change. (mhmedical.com)