Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.
Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.
A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS VULGARIS.
A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.
A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.
A nonselective beta-blocker used as an antihypertensive and an antianginal agent.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
Visible accumulations of fluid within or beneath the epidermis.
A group of desmosomal cadherins with cytoplasmic tails that resemble those of classical CADHERINS.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.
Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.
A family of structurally-related short-chain collagens that do not form large fibril bundles.
Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
A topical glucocorticoid used in the treatment of ECZEMA.
A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of livedo reticularis, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.
A form of epidermolysis bullosa characterized by serous bullae that heal without scarring. Mutations in the genes that encode KERATIN-5 and KERATIN-14 have been associated with several subtypes of epidermolysis bullosa simplex.
Form of epidermolysis bullosa having onset at birth or during the neonatal period and transmitted through autosomal recessive inheritance. It is characterized by generalized blister formation, extensive denudation, and separation and cleavage of the basal cell plasma membranes from the basement membrane.
A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.
The act or practice of killing for reasons of mercy, i.e., in order to release a person or animal from incurable disease, intolerable suffering, or undignified death. (from Beauchamp and Walters, Contemporary Issues in Bioethics, 5th ed)
White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.
Any horny growth such as a wart or callus.
Benign eccrine poromas that present as multiple oval, brown-to-black plaques, located mostly on the chest and back. The age of onset is usually in the fourth or fifth decade.
Coloration of the skin.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Irradiation directly from the sun.
Tumors or cancer of the SKIN.

The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic. (1/42)

Pemphigus vulgaris and pemphigus foliaceus are two closely related, but clinically and histologically distinct, autoimmune skin diseases. The autoantigens for pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively. The anti-desmoglein 1 antibodies in pemphigus foliaceus and anti-desmoglein 3 antibodies in pemphigus vulgaris are pathogenic as determined by immunoglobulin G passive transfer animal models. More than 50% of pemphigus vulgaris sera also contain anti-desmoglein 1 autoantibodies; however, the pathogenicity of the anti-desmoglein 1 autoantibodies in pemphigus vulgaris remains unknown. In this study, we used soluble recombinant extracellular domains of desmoglein 1 and desmoglein 3 to obtain affinity-purified anti-desmoglein 1 and anti-desmoglein 3 autoantibodies from pemphigus vulgaris sera and examined the pathogenicity of each fraction separately using the passive transfer mouse model. By immunoprecipitation, the purified anti-desmoglein 1 and anti-desmoglein 3 showed no cross-reactivity. The anti-desmoglein 1 autoantibodies in pemphigus vulgaris induced typical pemphigus foliaceus lesions in neonatal mice, whereas the anti-desmoglein 3 fraction induced pemphigus vulgaris-like lesions. In addition, the pathogenic anti-desmoglein 1 and anti-desmoglein 3 autoantibodies in pemphigus vulgaris had predominant IgG4 subclass specificity. These findings suggest that the anti-desmoglein 1 antibodies in pemphigus vulgaris are pathogenic.  (+info)

Immune modulation in pemphigus vulgaris: role of CD28 and IL-10. (2/42)

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease characterized by Abs to the desmosomal cadherin desmoglein-3. Although the autoantibodies have been shown to be pathogenic, the role of the cellular immune system in the pathology of pemphigus-induced acantholysis is unclear. To further delineate the potential role of T cell-signaling pathways in the pathogenesis of PV, we performed passive transfer experiments with PV IgG in gene-targeted mutant mice. Our results demonstrated that CD28-deficient mice (lacking a costimulatory signal for T cell activation) are 5-fold more sensitive to the development of PV than wild-type mice. To evaluate whether the higher incidence of disease was due to an impairment in intercellular adhesion of keratinocytes, we performed an in vitro acantholysis, using CD28-/- mice keratinocytes. No alteration in in vitro adhesion was detected in CD28-/--type keratinocytes. Because the CD28 molecule plays a pivotal role in the induction of Th2 cytokines, we examined the levels of a prototypic Th2 cytokine (IL-10) in CD28-/- mice. Lower levels of IL-10 mRNA were found in lesions from CD28-/- mice. To determine whether pemphigus susceptibility in CD28-/- was related to IL-10 deficiency, we performed passive transfer experiments in IL-10-/- mice that demonstrated increased blisters compared with controls. To confirm that IL-10 is involved in the pathogenesis, rIL-10 was given with PV IgG. IL-10 significantly suppressed the disease activity. These data suggest a potential role of IL-10 in PV.  (+info)

In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. (3/42)

Keratinocyte-derived cytokines have been implicated in the pathogenesis of a number of skin diseases. In this study we examined the possible role of keratinocyte-derived cytokines in the development of acantholysis in pemphigus vulgaris. Nineteen patients with pemphigus vulgaris, demonstrating the characteristic clinical, pathologic, and immunopathologic findings were studied. In situ immunolabeling demonstrated the presence of two cytokines interleukin-1alpha and tumor necrosis factor-alpha, in lesional and perilesional areas. Results were confirmed by reverse transcriptase-polymerase chain reaction, demonstrating overexpression of both cytokines in vivo. To study the role of these cytokines in the pathogenesis of pemphigus vulgaris both in vitro and in vivo studies were performed. The results of the in vitro study demonstrated that pemphigus vulgaris IgG induced interleukin-1alpha and tumor necrosis factor-alpha mRNA in the skin. The potential pathogenic role of these mediators was demonstrated by a blocking study using antibodies against human interleukin-1alpha and tumor necrosis factor-alpha in keratinocytes cultures. A combination of anti-interleukin-1alpha and anti-tumor necrosis factor-alpha antibodies inhibited in vitro pemphigus vulgaris IgG induced acantholysis. To confirm the role of interleukin-1 and tumor necrosis factor-alpha in pemphigus, we utilized passive transfer studies using interleukin-1 deficient mice (ICE-/-, interleukin-1beta-/-) and tumor necrosis factor-alpha receptor deficient mice (TNFR1R2-/-). Both groups demonstrated a decreased susceptibility to the passive transfer of pemphigus. Our data support the role of cytokines interleukin-1 and tumor necrosis factor-alpha in the pathogenesis of pemphigus vulgaris.  (+info)

Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. (4/42)

Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. It was assumed that PV is caused by anti-desmoglein (Dsg) 3 autoimmunity because absorption of PV sera with a chimeric baculoprotein containing the Dsg 3 and IgG1 portions, rDsg3-Ig-His, eliminated disease-causing antibodies. In this study we demonstrate that rDsg3-Ig-His adsorbs out autoantibodies to different keratinocyte antigens, including a non-Dsg 3 130-kd polypeptide. Because the pool of disease-causing PV IgGs contains antibodies against the keratinocyte acetylcholine receptor (AChR), we sought to identify the targeted receptor(s). Preincubation of monkey esophagus with PV antibodies blocked specific staining of the keratinocyte cell membrane with rabbit monoepitopic antibody to alpha9 AChR, indicating that this first of its kind AChR with dual, muscarinic and nicotinic pharmacology is targeted by PV autoimmunity. Anti-alpha9 antibody stained keratinocytes in a fishnet-like intercellular pattern, and visualized a single band at approximately 50 kd in Western blots of keratinocyte membrane proteins. Using step-by-step reverse transcription polymerase chain reactions with primers based on known alpha9 sequence regions, we identified the complete reading frame of human alpha9. Its amino acid sequence showed 85% similarity with rat alpha9. Treatment of keratinocyte monolayers with anti-alpha9 antibody induced pemphigus-like acantholysis, which could be reversed either spontaneously or by using the cholinergic agonist carbachol. We conclude that alpha9 is coupled to physiological regulation of keratinocyte adhesion, and its interaction with PV IgG may lead to blister development.  (+info)

Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. (5/42)

Pemphigus is an autoimmune disease of skin adhesion associated with autoantibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (Dsg) 1 and 3 and acetylcholine receptors. The notion that anti-Dsg antibodies alone are responsible for blisters in patients with pemphigus vulgaris (PV) stems from the ability of rDsg1 and rDsg3 to absorb antibodies that cause PV-like skin blisters in neonatal mice. Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. We injected into Dsg 3-lacking mice the PV IgGs that did not cross-react with the 160-kDa Dsg 1 or its 45-kDa immunoreactive fragment and that showed no reactivity with recombinant Dsg 1. We used both the Dsg3(null) mice with a targeted mutation of the Dsg3 gene and the "balding" Dsg3(bal)/Dsg3(bal) mice that carry a spontaneous null mutation in Dsg3. These PV IgGs caused gross skin blisters with PV-like suprabasal acantholysis and stained perilesional epidermis in a fishnet-like pattern, indicating that the PV phenotype can be induced without anti-Dsg 3 antibody. The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice. Therefore, mucocutaneous lesions in PV patients could be caused by non-Dsg antibodies.  (+info)

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris. (6/42)

Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes that is caused by anti-desmoglein 3 IgG autoantibodies. Recently, we generated an active disease mouse model for pemphigus vulgaris by adoptive transfer of splenocytes from immunized desmoglein 3-/- mice to Rag2-/- mice. In this study, we performed immunologic and histopathologic studies using this pemphigus vulgaris model in mice and compared the gross and microscopic phenotypes of pemphigus vulgaris model mice and desmoglein 3-/- mice. Pemphigus vulgaris model mice showed strong in vivo IgG, and weak IgA deposition on keratinocyte cell surfaces in stratified squamous epithelia, and produced circulating anti-desmoglein 3 IgG antibodies without apparent cross-reactivity to desmoglein 1, in enzyme-linked immunosorbent assays. The predominant IgG subclass was IgG1. Pemphigus vulgaris model mice and desmoglein 3-/- mice were almost indistinguishable in terms of both gross and microscopic findings. Both types of mice showed suprabasilar acantholysis in the stratified squamous epithelia, including the oral mucous membranes and traumatized skin around the snout or paws; however, some pemphigus vulgaris model mice demonstrated a more severe phenotype than desmoglein 3-/- mice. The esophagus and forestomach were affected in some pemphigus vulgaris model mice, but not in desmoglein 3-/- mice. Furthermore, eosinophilic spongiosis, which is found in early pemphigus vulgaris lesions in patients, was observed in pemphigus vulgaris model mice but not in desmoglein 3-/- mice. Pemphigus vulgaris model mice reflect several of the histopathologic and immunologic features seen in pemphigus vulgaris patients, and provide a valuable tool to investigate the pathophysiologic mechanisms of pemphigus vulgaris.  (+info)

Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. (7/42)

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease that is caused by IgG autoantibodies against the cadherin-type adhesion molecule desmoglein (Dsg)3. Previously, we have generated an active mouse model for PV by adoptive transfer of Dsg3(-/-) splenocytes. In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation. Intraperitoneal inoculation of the AK23 hybridoma, but not the other AK hybridomas, induced the virtually identical phenotype to that of PV model mice or Dsg3(-/-) mice with typical histology of PV. Epitope mapping with domain-swapped and point-mutated Dsg1/Dsg3 molecules revealed that AK23 recognized a calcium-dependent conformational epitope on Dsg3, which consisted of the V3, K7, P8, and D59 Dsg3-specific residues that formed the adhesive interface between juxtaposed Dsg, as predicted by the crystal structure. The epitopes of the mAbs that failed to show apparent pathogenic activity were mapped in the middle to carboxyl-terminal extracellular region of Dsg3, where no direct intermolecular interaction was predicted. These findings demonstrate the pathogenic heterogeneity among anti-Dsg3 IgG Abs due to their epitopes, and suggest the direct inhibition of adhesive interaction of Dsg as an initial molecular event of blister formation in pemphigus.  (+info)

A case of focal acantholytic dyskeratosis occurring on both the lip and the anal canal. (8/42)

Focal acantholytic dyskeratosis has a distinctive histological pattern that is associated with various clinical expressions. It rarely occurs on the lip or the perianal area. We report a patient with focal acantholytic dyskeratosis occurring on both the upper lip and the anal canal. Histopathologically, the lesions showed hyperkeratosis, suprabasilar clefting, epidermal acantholysis and dyskeratosis. This case represents the first report of a focal acantholytic dyskeratosis occurring on both the lip and the anal canal.  (+info)

Grovers disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with or without dyskeratosis. Once confirmed, most cases of Grovers disease last six to twelve months, which is why it was originally called transient. However it may last much longer. Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis. Grovers disease often starts quite suddenly. There are intensely itchy spots on the central back, mid chest and occasionally elsewhere. Frequently, it follows sweating or some unexpected heat stress. The itchy eruption lasts an average of 10-12 months. It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs. The papules are most commonly found on the mid chest. Sometimes the features of Grovers are found in people who do not itch or have a conspicuous rash. Most of the people with Grovers who visit a dermatologist, however, itch a ...
ACANTHOLYSIS: Review the definition, meaning, pronunciation, explanation, synonyms, and antonyms of the term ACANTHOLYSIS in the Online Dictionary. What is a 12 letter word that starts with A?
Complete information for ASCC2 gene (Protein Coding), Activating Signal Cointegrator 1 Complex Subunit 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Cancer Therapy Advisor provides dermatologists with the latest dermatology conditions, procedures and guides for different surgical and non surgical conditions. Visit often for updates and new information.
TY - JOUR. T1 - (3) Calcium enhances the sensitivity of immunofluorescence for pemphigus antibodies. AU - Matis, W. L.. AU - Anhalt, Grant James. AU - Diaz, L. A.. AU - Rivitti, E. A.. AU - Martins, C. R.. AU - Berger, Robert. PY - 1988. Y1 - 1988. UR - http://www.scopus.com/inward/record.url?scp=84988103834&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84988103834&partnerID=8YFLogxK. U2 - 10.1111/j.1365-2133.1988.tb05377.x. DO - 10.1111/j.1365-2133.1988.tb05377.x. M3 - Article. AN - SCOPUS:84988103834. VL - 119. SP - 42. JO - British Journal of Dermatology. JF - British Journal of Dermatology. SN - 0007-0963. ER - ...
AFX is a superficial fibrohistiocytic tumor that presents on the head and neck of elderly patients and is usually a pink or red, solitary, firm, asymptomatic papule or nodule.2,3 Histologically, AFX reveals a dermal proliferation of spindle and epithelioid cells with (often marked) pleomorphism, bizarre mitotic figures, and multinucleated cells.3 There are many variants of AFX, including spindle cell nonpleomorphic, clear cell, osteoclastic, and granular cell.3 Cutaneous squamous cell carcinoma (SCC) has a very diverse range of clinical and pathological subtypes including, but not limited to, acantholytic poorly differentiated and spindle cell.4 A patient with a forehead lesion containing both an SCCis arising within the wall of a trichilemmal cyst and surrounding AFX has been previously reported.1 AFX and SCC occurring together on the conjunctiva5 and face6 of patients with xeroderma pigmentosum have also been reported. It is not surprising to observe a collision of SCCis (or SCC) and AFX ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result
By Professor Martin M Black, MD. Pemphigus and its variants are rare autoimmune disorders characterized by loss of cell to cell cohesion between keratinocytes leading to intra-epidermal blistering. In all types of pemphigus, antibodies are directed against antigens in the intercellular substance between keratinocytes and in a substantial number of active cases, these pemphigus antibodies can be detected in the general blood circulation.. Pempigus vulgaris (PV) is characterized by flaccid blistering and erosions of the skin and mucous membranes. Involvement within the mouth may often precede the skin erosions and may persist even long after skin lesions subside. It is therefore important to remember that involvement of the oral cavity may take the patient to see dental surgeon, rather than a dermatologist in the first instance. However, in pemphigus foliaceus (PF) the blistering tends to be more superficial than in the vulgaris form of pemphigus and the mucous membrane areas are not ...
The first contribution to the chapter will require editorial approval before being published. Only high quality extensive reviews will be approved for initial publication.. Publishing on Dermpedia is easy. If you already have suitable content on file, it will not take much more than cut and paste to publish it on Dermpedia. Please see help for instructions. Dermpedia is designed to be user-editable, but yes, if you have great content, would like to become the Editor of this page, but have not time to edit this page, we will find helpers to publish it for you.. Registration is required.. Adding Cases and Images. You can add cases to book pages and either add images directly or attached to cases (preferred).. Add a case: Click on the Add a case link while on the book page and you will be asked to create a new case by filling in the necessary fields and pressing submit. Once youve done that, there is the further opportunity to add images to the case.. Add an image: Click on the Add an image ...
ASCC Student ID Card Fee The Student ID Card provides a college picture ID for use in campus labs, the library, the bookstore, and other locations on campus. It helps fund student jobs, student activities, critical campus programs and services, as well as providing discounts within the community. For more information about the ASCC card, see ASCC Student ID Card. This optional fee is nonrefundable once the semester begins. The ASCC card fee is not an eligible tax credit fee. The ASCC Student ID Card is to be purchases/renewed each semester, even if a student has already had her or his picture taken.. If the ASCC Student ID Card is lost, stolen, or mutilated, the student will be provided, free of charge, one replacement during the students Cuesta career. For any additional cards there is a $2 replacement fee. Contact the Student Life and Leadership Office at (805) 546-3289 for picture ID dates, times, and information.. Student Representation Fee A vote of the students during the Spring 2002 ...
In mammalian tissues, uptake of Ca(2+) and Mn(2+) by Golgi membranes is mediated by the secretory pathway Ca(2+) -ATPases, SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes. Loss of one copy of the ATP2C1 gene, which causes SPCA1 haploinsufficiency, leads to squamous cell tumors of keratinized epithelia in mice and to Hailey-Hailey disease, an acantholytic skin disease, in humans. Although the disease phenotypes resulting from SPCA1 haploinsufficiency in mice and humans are quite different, each species-specific phenotype is remarkably similar to those arising as a result of null mutations in one copy of the ATP2A2 gene, encoding SERCA2, the endoplasmic reticulum (ER) Ca(2+) pump ...
Insights from a desmoplakin mutation identified in lethal acantholytic epidermolysis bullosa.. J Invest Dermatol. 2010 Nov;130(11):2680-3. Authors: Hobbs RP, Han SY, van der Zwaag PA, Bolling MC, Jongbloed JD, Jonkman MF, Getsios S, Paller AS, Green KJ. PMID: 20613772 [PubMed - indexed for MEDLINE]. ...
Histologic examination revealed intraepidermal vesicles containing acantholytic cells and ulceration. There was ballooning degeneration of keratinocytes. Also,
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1LWN: Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
TY - JOUR. T1 - Unusual presentation of pemphigus vulgaris. AU - Bardazzi, F.. AU - Guerra, L.. AU - Peluso, A. M.. AU - Piraccini, B. M.. AU - Morelli, R.. PY - 1994. Y1 - 1994. N2 - We report a case of a 50-year-old man who presented with a conjunctival erosion and lesions resembling acute paronychia of several fingers. The Tzanck preparation from the conjunctiva showed the presence of acantholytic cells. Skin biopsy showed suprabasal cleft formation with acantholysis. Direct immunofluorescence revealed intercellular epidermal staining with IgG and C3. Diagnosis of pemphigus vulgaris was therefore confirmed. Nail abnormalities that can be observed in pemphigus vulgaris are discussed.. AB - We report a case of a 50-year-old man who presented with a conjunctival erosion and lesions resembling acute paronychia of several fingers. The Tzanck preparation from the conjunctiva showed the presence of acantholytic cells. Skin biopsy showed suprabasal cleft formation with acantholysis. Direct ...
Define pemphigus vulgaris. pemphigus vulgaris synonyms, pemphigus vulgaris pronunciation, pemphigus vulgaris translation, English dictionary definition of pemphigus vulgaris. n. Any of several acute or chronic skin diseases characterized by groups of itching blisters. pem′phi·gous adj. n pathol any of a group of blistering skin...
RESULTS: Of the 72 patients, 63 (88%) were men, and the mean age was 48 years (range, 31 to 85). Lesions were distributed mainly on the trunk (in 71 patients) and proximal extremities (in 25). Heat and sweating frequently were exacerbating factors. Fifteen patients (21%) were bedbound. Concurrent nondermatologic malignant disease was present in 18 patients (25%). Two patients (3%) had acquired immunodeficiency syndrome. Follow-up in 28 patients (mean, 38 months; range, 3 months to 7 years) revealed that the disease had recurred in 13, persisted in 3, and resolved in 12. Review of the biopsy specimens showed that acantholysis was pemphigus vulgaris-like in 40 patients (56%), Dariers disease-like in 16 (22%), spongiotic in 12 (17%), pemphigus foliaceus-like in 2 (3%), and Hailey-Hailey disease-like in 2 (3%). A perivascular lymphocytic infiltrate of varied intensity in 64 specimens (89%) was associated with eosinophils in 16 (22%). In nine biopsy specimens with dermal eosinophilia stained for ...
The American Samoa Community College (ASCC) will hold its 67th commencement ceremony on Friday, December 15th, at 10 a.m. in the Colleges gymnasium. Governor Lolo M. Moliga and other dignitaries have been invited to join this semesters celebration of the young men and women who have completed their degrees and certificates, including three students who have earned their Bachelor in Education (BEd) diplomas. A preliminary count of 103 ASCC graduates will celebrate an important milestone in their lives, though the actual number may change depending on examination results or other factors.. As always, the College has sought out a distinguished member of the community to offer words of congratulations and encouragement to the graduates. ASCC alumnus William Ena Spitzenberg may not be as well-known as some of the previous speakers, but he has traveled far, made advancements within his chosen career, and has now returned home to contribute to the betterment of his home, just as many young American ...
Anal Squamous Cell Carcinoma (ASCC) is an uncommon cancer with an incidence rate between 1 and 2 per 100000 per year. However, the incidence of ASCC is increasing rapidly, with up to 6.8% increase in men per year and 10.7% increase in women per year since 1971.. It is believed that the increasing numbers of HIV positive patients who are living longer on advanced antiretrovirals are likely to be contributing to the increasing burden of ASCC. Anal Intraepithelial Neoplasia (AIN) is the known precursor to ASCC. It is believed that by identifying and treating high grade AIN that ASCC could become a preventable cancer. ASCC also has excellent outcomes if identified early. Only 15% of ASCC present with metastasis and most patients are diagnosed with resectable T1 tumours. However, current guidelines are conflicting and not based on good quality clinical evidence, The limiting factor to providing good quality evidence is the large samples size required to observe the relationship between AIN ...
What are the aims of this leaflet?. This leaflet has been written to help you understand more about Dariers disease. It tells you what it is, what causes it and what can be done about it including treatment options. It provides other sources where you can find out more information about it.. What is Darier disease?. It is a rare inherited skin condition, estimated to affect 1 to 4 people per 100,000 of the population and is characterised by a change in the way skin cells (keratinocytes) stick together within the upper layer of the skin (epidermis). This leads to changes in the skin and nails, and sometimes inside the mouth can be affected. Other names for Darier disease include Darier-White disease and Keratosis Follicularis.. What causes Darier disease?. The movement of calcium within cells is disrupted, leading to a change in the way skin cells are held together. Normally, these cells are held together like bricks cemented in a wall. In Darier disease, the cement that holds the skin cells ...
It isnt often that a high level official such as the Director of the National Oceanic and Atmospheric Administration (NOAA) Office of the National Marine Sanctuaries (ONMS) travels to American Samoa and makes time to speak with college students.. The American Samoa Community College (ASCC) was honored to have Mr. John Armor, Director of ONMS, spend an hour talking with ASCC Marine Science Program and Agriculture, Community and Natural Resource (ACNR)/Land Grant students on March 31st.. Armor spoke about how he fell in love with the ocean at a young age, and how he persevered throughout his career to ultimately end up where he is today, as the Director of the entire National Marine Sanctuary program.. He recounted the hard work he put into seeking out opportunities in his field of interest, and how important it is to not be discouraged if you arent accepted to your first, second, or even third attempts to get a job or an internship.. Armor shared how his first marine internship after college ...
Kirov State Medical University. The article describes modern views on predisposing factors, characteristics of the immunological changes and link with the histocompatibility antigens HLA, the role of circulating autoantibodies in the pathogenesis of the disease in patients with pemphigus vulgaris. Described 2 cases of clinical observations and vulgar pemphigus, foliaceous pemphigus, accompanied by concomitant pathology of internal organs in the form of cardiovascular system pathology, chronic iron deficiency anemia, diffuse and knotty changes of the thyroid gland. The good effect of etiotropic, pathogenetic and symptomatic therapy in accordance with the standards of specialized medical care in moderate-to-severe pemphigus. ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
Javier Rangel, MD Perm J 2016 Winter; 20(1):e101-e102 http://dx.doi.org/10.7812/TPP/15-059 Abstract The development of pemphigus, including
Looking for information on Dog Pemphigus in Fargo? We have compiled a list of businesses and services around Fargo that should help you with your search. We hope this page helps you find information on Dog Pemphigus in Fargo.
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Santa, Mrs. Claus and the Hoisington Chamber of Commerce staff agree, tonight is not a great night for be out and about. So, they are rescheduling the Christmas Lighting celebration to Tuesday, Dec. 8. The city lights will still be turning on tonight, but plan to come up to the Chamber and Santa House on Dec. 8 to see Santa and Mrs. Claus, enjoy cocoa and cookies and sign up for Chamber Gift Certificates and the 50/50 Winter raffle. ...
Risks for Pemphigus foliaceus, Pemphigus foliaceus treatments, recommended products for Pemphigus foliaceus, ways to prevent Pemphigus foliaceus, causes of Pemphigus foliaceus
TY - JOUR. T1 - Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. AU - Kamiya, K.. AU - Aoyama, Y.. AU - Yamasaki, O.. AU - Kamata, A.. AU - Yamagami, Jun. AU - Iwatsuki, K.. AU - Tokura, Y.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Background Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are closely related, but clinically distinct, autoimmune blistering diseases caused by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. Using ethylenediaminetetraacetic acid (EDTA)-treated Dsg3 enzyme-linked immunosorbent assay (ELISA) we have shown that the proportion of anti-Dsg3 antibodies against calcium-dependent epitopes decreased upon shifting to the inactive phase in patients with PV. Objectives To analyse the epitope profiles of anti-Dsg1 antibodies across the different activity stages of PF. Methods We evaluated five patients with PF who retained high serum levels of anti-Dsg1 antibodies in the inactive phase. ...
HAILEY-HAILEY DISEASE. What are the aims of this leaflet?. This leaflet has been written to help you understand more about Hailey-Hailey disease. It tells you what it is, what causes it, what can be done about it, and where you can find out more about it.. What is Hailey-Hailey disease?. Hailey-Hailey disease is also known as familial benign chronic pemphigus, as originally described by the Hailey brothers. It is a rare inherited skin condition in which red scaly areas that can be itchy and sore, can lead to superficial blisters and eroded (broken) areas of the skin folds of the groin, armpits, neck and under the breasts. The condition flares intermittently and tends to come and go. Many patients are able to lead full and normal lives, with their condition being a nuisance rather than a serious problem. Some patients are more severely affected and experience more persistent painful raw areas of the skin with development of superficial blisters.. What causes Hailey-Hailey disease?. A small error ...
Background: Cantharidin is a topical vesicant that causes intraepidermal acantholysis with clinical application that includes the removal of warts, molluscum contagiosum (MC), calluses, and acquired perforating dermatoses. Objective: To provide a com
What is Pemphigus Vulgaris or Skin & mouth Blisters? Get treatment for blisters on Skin & in Mouth. The Esthetic Clinic provides the best in class treatment for Pemphigus Vulgaris or Skin & mouth Blisters in Mumbai and India. Best Dermatologist for skin diseases, Contact details - [email protected] or +91-9004671379
Desmoglein 3 antibody [3G133] (desmoglein 3) for ICC/IF, IHC-P, IP, WB. Anti-Desmoglein 3 mAb (GTX14416) is tested in Human samples. 100% Ab-Assurance.
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Pemphigus foliaceus is a rare autoimmune disorder that causes people to have skin that blisters easily and develops crusty, scaly...
Pemphigus Vulgaris is mainly characterized by a formation of blisters in the mouth which make it difficult to swallow food or drink water. These blisters later
Polyclonal antibody for Desmoglein 3/DSG3 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Desmoglein 3/DSG3 information: Molecular Weight: 107533 MW; Subcellular Localization: Cell membrane ; Single-pass type I
尋常性天疱瘡に検出されるデスモグレイン3のカルシウム非依存性構造に対する抗体とその病因性への関 ...
Rabbit recombinant monoclonal Desmoglein 1 antibody [EPR6766(B)] validated for WB, IHC and tested in Human, Mouse and Rat. Referenced in 1 publication and 4…
The rest of December went well, eye healing up and skin was getting better. After the surgery Otis started to gain weight and muscle. I think the eye was bothering him for much longer than we knew. Somewhere in the back of my mind I crossed my fingers that the tumor had caused all of…
This weeks colors are B24, G24 and Y21 and any other green. As with all Kimms Copic Challenges, you can use 1,2 or all 3 of her color suggestions (or something close). The names of the colors really grabbed me - Sky, Willow, and Buttercup Yellow! These enticing descriptors got me thinking about the summer fields and open sky. Looking around my craft area, I realized I had just enough (formerly) 12 x 12 cardstock to make one last Triple Play card, a Technique Junkie idea that makes a card that fits in a regular #10 envelope. That got me thinking about snail mail...and well the rest is history! ...
Argenx discovers, designs and develops innovative antibody therapeutics for its own pipeline of treatments for cancer and autoimmune diseases and for its partners. Harnessing our technology and know-how, we aim to meet the needs of patients by engineering antibodies to target diseases too complex for other antibody technologies.
This rare autoimmune disorder caused a womans vulva to swell up and break out in blisters. We spoke to a dermatologist to find out how that happens.
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
TY - JOUR. T1 - Pemfigo radioindotto con ritardo diagnostico. AU - Hendrickx, I.. AU - Guizzardi, M.. AU - Mancini, L. L.. AU - Monti, M.. PY - 1999. Y1 - 1999. N2 - Ionizing radiation-induced pemphigus is a rare reported clinical entity, arising after a radiation therapy that usually follows surgical treatment for malignancy. A case of ionizing radiation-induced pemphigus arised after X-ray therapy for mammary carcinoma is reported. After two weeks of X-ray delivery, erythema and erosions appeared on the radiated area. These lesions were interpreted as an inflammatory result of radiation and cured. After eighteen months, typical pemphigus bullous eruptions developed all over the body and oral mucosa. The importance of considering ionizing radiation-induced pemphigus among the attending side effects of radiotherapy is underlined and it is suggested to submit to dermatological attention every case of uncertain skin reaction.. AB - Ionizing radiation-induced pemphigus is a rare reported clinical ...
Background: Pemphigus is a rare, autoimmune blistering condition, resulting in significant morbidity and mortality. It warrants treatment by various immunosuppressive age..
I have just been diagnosed with Pemphigus. I dont know what to expect. I see my doctor on Friday for the first time. I am always tired. Is this a symptom of...
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Seshadri, Divya (2013). "Acantholysis revisited: Back to basics". Indian J Dermatol Venereol Leprol. 79 (1): 120-6. doi:10.4103 ...
The process leads to the loss of cellular connections (acantholysis) and ultimately blistering of the skin. Lesions heal ... Bertaux, B.; Prost, C.; Heslan, M.; Dubertret, L. (1988). "Cantharide acantholysis: endogenous protease activation leading to ...
This in turn causes a loss of adhesion with acantholysis as a result. The National Institute of Arthritis and Musculoskeletal ...
In addition to blistering, other symptoms which accompany HHD include acantholysis, erythema and hyperkeratosis. The cause of ... causing acantholysis, blisters and rashes. There is no known cure.[citation needed] While the term pemphigus typically refers ...
The pathologist looks for an intraepidermal vesicle caused by the breaking apart of epidermal cells (acantholysis). Thus, the ... a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these blisters can ... and acantholysis. The least common and most severe type of pemphigus is paraneoplastic pemphigus (PNP). This disorder is a ... acantholysis), and by the presence of pathogenic (predominantly IgG) autoantibodies reacting against epithelial adhesion ...
... and acantholysis. Early descriptions were made by Darrell Wilkinson, a British dermatologist. Pemphigus List of cutaneous ...
PV is manifested by suprabasal acantholysis, or blisters in the mucous membrane and blisters in the epidermis. PF patients have ...
These blisters are due to acantholysis, or breaking apart of intercellular connections through an autoantibody-mediated ...
Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with ...
This results from the disruption of tonofilaments in the desmosomes with acantholysis and intra-epidermal blister formation. " ...
... are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". The Journal ...
... is characterized by a tubular microscopic pattern and keratinocyte acantholysis. Basaloid squamous cell carcinoma is ...
... pemphigoid does not feature acantholysis, a loss of connections between skin cells. Pemphigoid is more common than pemphigus, ...
... nondyskeratotic acantholysis. List of cutaneous conditions James, William; Berger, Timothy; Elston, Dirk Andrews' Diseases of ...
... epidermal acantholysis (breaking apart of the skin), dyskeratotic keratinocytes and vacuolar changes in the layers of the skin ... Histologic evidence of acantholysis (loss of intercellular connections leading to breaking apart of the skin; lesion) Direct ...
Poikiloderma Hyperkeratosis Parakeratosis Hypergranulosis Acanthosis Papillomatosis Dyskeratosis Acantholysis Spongiosis ...
... acantholysis MeSH C17.800.865.187 - blister MeSH C17.800.865.360 - dermatitis herpetiformis MeSH C17.800.865.385 - eczema, ...
... is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes ... ISBN 0-7216-0187-1. "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Archived from the original on 2016- ...
Disuse atrophy of muscles and bones, with loss of mass and strength, can occur after prolonged immobility, such as extended bedrest, or having a body part in a cast (living in darkness for the eye, bedridden for the legs etc.). This type of atrophy can usually be reversed with exercise unless severe. Astronauts in microgravity must exercise regularly to minimize atrophy of their limb muscles. There are many diseases and conditions which cause atrophy of muscle mass. For example, diseases such as cancer and AIDS induce a body wasting syndrome called cachexia, which is notable for the severe muscle atrophy seen. Other syndromes or conditions which can induce skeletal muscle atrophy are congestive heart failure and liver disease. During aging, there is a gradual decrease in the ability to maintain skeletal muscle function and mass. This condition is called sarcopenia, and may be distinct from atrophy in its pathophysiology. While the exact cause of sarcopenia is unknown, it may be induced by a ...
... is mainly intercellular[1] edema (abnormal accumulation of fluid) in the epidermis,[2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification.[3] It is a severe case of eczema that affects the epidermis, dermis and/or subcutaneous skin tissues.[4][5] The three types of spongiotic are acute, subacute and chronic.[5] A Dermatologist can diagnose acute spongiotic by examining your skin during an office visit but a biopsy is needed for an accurate diagnosis of the type.[6] It can be caused by several internal or external factors such as food, an insect bite, stress, medication or cosmetics. The treatment varies depending on the type and severity; it is normally treated with topical corticosteroid cream.[6] ...
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system-the organ system that encloses the body and includes skin, hair, nails, and related muscle and glands.[1] The major function of this system is as a barrier against the external environment.[2] Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails).[3][4] While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described.[5] Classification of these conditions often presents many nosological challenges, since underlying causes and pathogenetics are often not known.[6][7] Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology (chronic blistering conditions), cause (skin conditions ...
With regard to the quote "...varying in size from a pinhead to 1cm," depending on which text is referenced, some authors state the cutoff between a papule and a plaque as 0.5cm, not 1cm, while others state an entirely different measurement. Therefore, for this article, the 1cm cutoff is used which is discussed in Andrews' Diseases of the Skin: Clinical Dermatology (see references), a work considered by some dermatologists as an authority on this subject matter. See Lack of Standardization for complete discussion. ...
In terms of pathology, the first signs of the condition may be observed within the dermis. The changes that may take place at this level may include edema, vascular dilatation, and cellular infiltration. It is common for lymphocytes and eosinophils to be seen. The bullae found in the skin affected by dermatitis herpetiformis are subepidermal and have rounded lateral borders. When looked at under the microscope, the skin affected by dermatitis herpetiformis presents a collection of neutrophils. They have an increased prevalence in the areas where the dermis is closest to the epidermis. Direct IMF studies of uninvolved skin show IgA in the dermal papillae and patchy granular IgA along the basement membrane. The jejunal mucosa may show partial villous atrophy, but the changes tend to be milder than in coeliac disease.[18] Immunological studies revealed findings that are similar to those of coeliac disease in terms of autoantigens. The main autoantigen of dermatitis herpetiformis is epidermal ...
... is primarily caused by uroporphyrinogen decarboxylase deficiency (UROD). Uroporphyrinogen decarboxylase occurs in nature as a homodimer of two subunits. It participates in the fifth step in heme synthesis pathway, and is active in the cytosol. This enzymatic conversion results in coproporphyrinogen III as the primary product. This is accomplished by the clockwise removal of the four carboxyl groups present in the cyclic uroporphyrinogen III molecule. Therefore, a deficiency in this enzyme causes the aforementioned buildup of uroporphyrinogen and hepta-carboxylic porphyrinogen, and to a lesser extent hexa-carboxylic porphyrinogen, and penta-carboxylic porphyrinogen in the urine, which can be helpful in the diagnosis of this disorder.[16][17] The dermatological symptoms of PCT that include blistering and lesions on sun-exposed areas of the skin are caused by a buildup of porphyrin compounds (specifically uroporphyrinogen) close to the surface of the skin that have been ...
The autoimmune reaction most commonly affects the mouth, causing lesions in the gingiva or gums, but it can also affect areas of mucous membrane elsewhere in the body, such as the sinuses, genitals and anus. When the cornea of the eye is affected, repeated scarring may result in blindness. Localized cicatricial pemphigoid (also known as "Brunsting-Perry cicatricial pemphigoid"[1]) refers to a localised variant of cutaneous cicatricial pemphigoid involving the head and the neck without mucosal involvement.[1] Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. In contrast, in Pemphigus, the epithelium tends to disintegrate rather than form a bulla. Nikolsky's sign is present pemphigus and cicatricial pemphigoid, but not in bullous pemphigoid. ...
ത്വക്കിലോ മ്യൂക്കസ് പാളിയിലോ ഉണ്ടാകുന്ന വൃണത്തെയാണ് സാധാരണഗതിയിൽ അൾസർ എന്നു വിളിക്കുന്നത്. ഇതോടൊപ്പം കലകളുടെ നാശവും ഉണ്ടാകും. ഈ വൃണങ്ങൾ കാരണം എപിഡെർമിസും പലപ്പോഴും ഡെർമിസിന്റെയും തൊലിക്കടിയിലുള്ള കൊഴുപ്പിന്റെപോലും നാശമുണ്ടാകാം. കാലുകളിലാണ് കൂടുതലും ത്വക്കിലെ അൾസറുണ്ടാകുന്നത്. തൊലിയിലുണ്ടാകുന്ന അൾസറിനു ചുറ്റും കോശജ്വലനം മൂലം ചുവന്ന തൊലിയാവും ഉണ്ടാവുക. ചൂടോ, ...
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes ... ISBN 0-7216-0187-1. "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Archived from the original on 2016- ...
acantholysis synonyms, acantholysis pronunciation, acantholysis translation, English dictionary definition of acantholysis. ... Noun 1. acantholysis - a breakdown of a cell layer in the epidermis disease of the skin, skin disease, skin disorder - a ... acantholysis. Also found in: Thesaurus, Medical, Wikipedia.. Related to acantholysis: pemphigus, acanthosis, dyskeratosis, ... Acantholysis - definition of acantholysis by The Free Dictionary https://www.thefreedictionary.com/acantholysis ...
... and antonyms of the term ACANTHOLYSIS in the Online Dictionary. What is a 12 letter word that starts with A? ... ACANTHOLYSIS: Review the definition, meaning, pronunciation, explanation, synonyms, ...
"Acantholysis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Acantholysis" by people in Harvard Catalyst Profiles by year, ... Below are the most recent publications written about "Acantholysis" by people in Profiles. ... and whether "Acantholysis" was a major or minor topic of these publication. ...
E. Sanchez Yus, L. Requena, P. Simon, and C. Martin de Hijas, "Incidental acantholysis," Journal of Cutaneous Pathology, vol. ... Figure 4: Incidental focus of Hailey-Hailey-like acantholysis, occurring in association with a benign keratosis with features ... In the largest studies, incidental acantholysis was identified in 14 of 9000 specimens [35], and incidental FAD was identified ... Occasionally, these patterns are combined in a single specimen, and foci of acantholysis with overlapping histologic patterns ...
Lichenifcation & Acantholysis Flashcards Preview Dermatology - Clinical Medicine IV , Lichenifcation & Acantholysis , ...
... acantholysis explanation free. What is acantholysis? Meaning of acantholysis medical term. What does acantholysis mean? ... Looking for online definition of acantholysis in the Medical Dictionary? ... acantholysis. Also found in: Dictionary, Thesaurus, Wikipedia.. Related to acantholysis: pemphigus, acanthosis, dyskeratosis, ... acantholysis. Splitting apart of layers of cells in the epidermis often top form a blister.. acantholysis. atrophy or ...
... Dermatit Grovera presence is original reaction of skin by astenised people, ...
acantholysis Reference type: Overview Page. Subject: Medicine and health, Dentistry. The breakdown of epidermal or epithelial ...
Seshadri, Divya (2013). "Acantholysis revisited: Back to basics". Indian J Dermatol Venereol Leprol. 79 (1): 120-6. doi:10.4103 ...
1988) Cantharidin-induced acantholysis. Am J Dermatopathol 10:419-423.. OpenUrlPubMed ...
Vitamin E may hold promise for the treatment of acantholysis.Nov 01, 1993. ...
Acantholysis: worth a second look?. Howard JC, Russell KJ, Vickers JL, Weiss E. ...
histology: without epidermal acantholysis. For the pemphigus group:. *patient with pemphigus. For the lupus group:. *systemic ...
Acantholysis is not prominent; however, it has been reported in older lesions. See the image below. ... Unlike pemphigus, a predominance of neutrophils and an absence or moderate acantholysis is observed; additionally, the ...
Paraneoplastic pemphigus acantholysis. . . . Investigations Serum electrolytes, glucose and bicarbonate are essential to assess ...
Pemphigus vulgaris; Desmogleins; Acantholysis; Clinical pharmacist. Introduction. Phosphoribosylpyrophosphate synthetase-1 ( ...
2004) Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists. Arch Dermatol 140(3):327-334. ... 2007) Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: Characterization of novel signaling pathways ...
Histologically, minimal or no apparent acantholysis is associated.] ...
Huggins, R. H., Bolling, M. C., Diercks, G. F. H., & Jonkman, M. F. (2008). Focal acantholysis in junctional epidermolysis ... Extensive acantholysis as the major histological feature of a severe case of Dowling Meara-epidermolysis bullosa simplex: a ... reappraisal of acantholysis in the newborn. European journal of dermatology, 21(6), 966-971. https://doi.org/10.1684/ejd. ...
Acantholysis is present in this actinic keratosis. The degree of acantholysis can vary. Such a lesion may show histologic ... Acantholysis is present in this actinic keratosis. The degree of acantholysis can vary. Such a lesion may show histologic ... Acantholysis is present in this actinic keratosis. The degree of acantholysis can vary. Such a lesion may show histologic ... Acantholysis is present in this actinic keratosis. The degree of acantholysis can vary. Such a lesion may show histologic ...
Complete information for LAMC2 gene (Protein Coding), Laminin Subunit Gamma 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
acantholysis bullosa. - elite association - COSMIC cancer census association via MalaCards Search LAMC1 in MalaCards View ...
Biopsy reveals characteristic suprabasilar acantholysis and intraepidermal bullae formation. Immunofluorescence is similar to ...
Apoptosis is not required for acantholysis in pemphigus vulgaris.. Schmidt E, Gutberlet J, Siegmund D, Berg D, Wajant H, ...
The Incidence of Acantholysis in Pityriasis Rubra Pilaris-Histopathological Study Using Multiple-Step Sections and ...
Pemphigus acantholysis and steric hindrance: an unsolved equation Nicola Cirillo Metrics. *Article usage ...
Acantholysis. 0100792 Autosomal recessive. inheritance. 0000007 Cardiomegaly. Enlarged heart Increased heart size ...
  • Desmosome function is disrupted by autoantibodies (Abs), resulting in acantholysis of keratinocytes in the epidermis. (thefreedictionary.com)
  • Histology showed hyperkeratosis, parakeratosis with some areas showing intraepidermal vesiculation and acantholysis similar to Hailey-Hailey disease, while other areas were more like Darier's disease showing dyskeratotic cells throughout the epidermis, including Corps ronds and grains. (thefreedictionary.com)
  • In the upper layers of the epidermis, where Dsg3 is not expressed and cannot compensate for Dsg1 loss, ongoing depletion of Dsg1 will finally result in a total disappearance of desmosomes and subsequent acantholysis. (pemphigus.org)
  • Acantholysis affects all levels of the epidermis in a "dilapidated brick wall" pattern ( Figure 2 , Figure 3 ). (renalandurologynews.com)
  • Histopathologic examination of the vulvar biopsy specimen revealed a suprabasal separation of the epidermis with acantholysis and dyskeratosis. (thedoctorsdoctor.com)
  • The mechanism is loss of the normal cell-to-cell adhesion of keratinocytes in the epidermis (acantholysis). (gponline.com)
  • Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis. (uni-muenchen.de)
  • Pemphigus vulgaris (PV) is an immune-mediated blistering skin disease characterized by acantholysis of the suprabasal epidermis and by IgG autoantibodies targeting a desmosomal component, desmoglein 3. (ovid.com)
  • 1] Pemphigus is caused by autoantibody (IgG) deposition against Desmoglein (1 and 3) antigens located in the desmosomes of epidermal keratinocytes or 9[alpha] nicotinic acetylcholine receptors, leading to acantholysis and intraepidermal cleft formation. (thefreedictionary.com)
  • The disease is characterized histologically by the presence of acantholysis, that is, the separation of the keratinocytes resulting in the formation of intraepidermal cleavage, and/or immunologically by the detection of autoantibodies against intercellular adhesion molecules called desmogleins (Dsg), which are transmembrane desmosomal glycoproteins. (scielo.br)
  • The term "penphigus" (signifying blister) is used for denoting a particular group of dermatoses characterized histologically by intraepidermal bullae and acantholysis. (hubpages.com)
  • 2. Histological findings of vacuolar interface change, keratinocyte necrosis, and intraepidermal acantholysis. (cancernetwork.com)
  • Coxsackie virus infection/hand foot and mouth disease: Blisters show intraepidermal vesiculation and acantholysis without nuclear inclusions or multinucleation. (dermnetnz.org)
  • Histologically, the acantholysis seen in Grover disease occurs in a variety of different patterns in small, circumscribed foci resembling Darier-White disease, pemphigus vulgaris, pemphigus foliaceous, Hailey-Hailey disease, and a spongiotic dermatitis. (thefreedictionary.com)
  • Histologically, minimal or no apparent acantholysis is associated. (ebi.ac.uk)
  • Grover's disease is a benign papular skin disease characterised histologically by acantholysis. (heine.com)
  • Focal acantholytic dyskeratosis (FAD), epidermolytic hyperkeratosis (EHK), and Hailey-Hailey-like acantholysis (HH) represent unique histology reaction patterns, which can be associated with defined phenotypic and genotypic alterations. (hindawi.com)
  • 247 consecutive skin specimens covering a three-month period (1/04-3/04) were reviewed by the author to identify incidental foci of Hailey-Hailey-like acantholysis (HH) and focal acantholytic dyskeratosis (FAD). (hindawi.com)
  • Epithelial component revealed foci of acantholysis and dyskeratosis. (lww.com)
  • In a histological examination you can see a circumscribed acantholysis with suprabasal or subcorneal gap formations, often accompanied by a spongiosis and a dyskeratosis. (heine.com)
  • Histopathologically, focal acantholysis and dyskeratosis is seen as well as occasional spongiosis. (neurologyadvisor.com)
  • Histopathologic findings include multiple areas of suprabasilar acantholysis with dyskeratosis, corps ronds and columns of parakeratosis (grains). (neurologyadvisor.com)
  • Finally, acantholytic actinic keratosis and squamous cell carcinoma may present with acantholysis and dyskeratosis, but differs in demonstrating atypical keratinocytic proliferation with cytologic atypia and mitoses. (neurologyadvisor.com)
  • Skin biopsy was performed on the abdominal skin lesion and the histology showed suprabasal acantholysis with bullous cleft formation, which was compatible with PNP [Figure 1]f. (thefreedictionary.com)
  • Biopsy from papular lesions showed suprabasal acantholysis , acantholytic and dyskeratotic cells. (thefreedictionary.com)
  • Background: Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. (pemphigus.org)
  • Pemphigus vulgaris will show suprabasal acantholysis (loss of intercellular adhesion between intact keratinocytes), resulting in a blister just above the basal cell layer. (clinicaladvisor.com)
  • Pemphigus vulgaris histology showing suprabasal acantholysis. (clinicaladvisor.com)
  • suprabasal acantholysis with villous epidermal projections are seen underneath. (jle.com)
  • Suprabasal acantholysis is noted with vesicle formation in advanced lesions, and small numbers of acantholytic cells are seen within this space. (dermnetnz.org)
  • Antibody blockade of desmoglein 3 function in pemphigus vulgaris patients leads to skin blistering (acantholysis) and oral mucosa lesions. (mendeley.com)
  • Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients. (mendeley.com)
  • The positive result for desmoglein antibodies could be due to unmasking of antigens by the mechanism of acantholysis. (em-consulte.com)
  • Pemphigus is an uncommon autoimmune condition in which circulating autoantibodies against intercellular adhesion molecules result in acantholysis , or loss of keratinocyte adhesion. (thefreedictionary.com)
  • Biopsy of an early lesion reveals acantholysis and blister formation with overlying crust (X20). (renalandurologynews.com)
  • Following topical administration to the skin, cantharidin, a protein phosphatase inhibitor, induces atraumatic acantholysis and blister formation. (ucl.ac.uk)
  • Pemphigus vulgaris is autoimmune disease characterized by acantholysis and blister formation in the skin and mucosa. (koreamed.org)
  • Abnormal immune response resulting in auto-antibodies directed against surface proteins on the keratinocyte, which provide intercellular adherence → loss of intercellular cohesion → acantholysis and blister formation. (vetstream.com)
  • Presence of acantholytic cells in the granular layer (arrow), neutrophilic PMN (circle) and acantholysis (asterisk) 10x. (thefreedictionary.com)
  • lesion) Direct immunofluorescence showing intercellular and basement membrane staining Indirect immunofluorescence staining with rat bladder epithelium Microscopy of the skin sample obtained from the biopsy is used to detect the presence of cleavage within the dermis, epidermal acantholysis (breaking apart of the skin), dyskeratotic keratinocytes and vacuolar changes in the layers of the skin, interfacial dermatitis, and epidermal exocytosis. (wikipedia.org)
  • Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. (wikipedia.org)
  • Sometimes, there is clefting at the periphery of the squamous eddies and even focal acantholysis. (mohscollege.org)
  • It is highly irritating and causes acantholysis and vesicle formation when in contact with skin or mucous membranes. (alliedacademies.org)
  • The mechanism by which mutant ATPC1 causes acantholysis is unknown, but it may be through abnormally elevated cytoplasmic calcium or abnormally low Golgi Ca(2+) levels. (hfea.gov.uk)
  • Diagnosis of pemphigus is based on the clinical (flaccid bullae, vesicles, and erosions on the epithelium of mucous membranes and skin), typical histological (epidermal acantholysis), and fluorescent findings (circulating and bound skin antibodies directed against keratinocyte surface), followed by the Tzanck test which involves cytological examination of the material scraped from the floor of a bulla [ 2 ]. (termedia.pl)
  • There is suprabasilar acantholysis with dyskeratotic keratinocytes demonstrating corps ronds and corps grains ( Figure 2 ). (neurologyadvisor.com)
  • The results indicate that in different pemphigus patients, IgG-induced acantholysis proceeds predominantly via distinct, yet complementary, pathways of programmed cell death and that IVIg protect target cells by up-regulating endogenous caspase and calpain inhibitors. (uci.edu)
  • A definitive diagnosis of PV is made when Nikolsky's sign is positive, in the presence of acantholysis in histopathology and by direct immunofluorescence [2]. (thefreedictionary.com)
  • Additionally, histopathologic examination was performed to analyse the presence and degree of acantholysis and a direct immunofluorescence test was performed to analyse intercellular IgG and C3 deposits (chicken-wire appearance). (termedia.pl)
  • Shave biopsy revealed full-thickness atypia and acantholysis of keratinocytes. (lww.com)
  • Treatment acantholysis on biopsy. (goodbelly.com)
  • Biopsy reveals acantholysis (separation) of keratinocytes (X40). (renalandurologynews.com)
  • This disease is characterized by a disruption of cell-cell contacts (acantholysis) in the suprabasal layers of the skin. (mpg.de)
  • Frusic-Zlotkin M, Raichenberg D, Wang X, David M, Michel B, Milner Y. Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis--possible involvement of the EGF receptor. (harvard.edu)
  • Wang X, Brégégère F, Frusic-Zlotkin M, Feinmesser M, Michel B, Milner Y. Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins. (harvard.edu)
  • Conclusion We propose the following mechanism for acantholysis in PF: initially PF IgG causes a depletion of non-junctional Dsg1, leading to intercellular widening between desmosomes starting in the lower layers and spreading upwards. (pemphigus.org)
  • This mechanism yields acantholysis, which is the loss of adhesion among cells of the Malpighi layer. (vin.com)
  • This process, referred to as acantholysis, manifests clinically with the formation of flaccid blisters and erosions of the skin and mucous membranes. (uni-marburg.de)
  • Subcorneal vesicles and pustules with prominent acantholysis which may involve hair follicle rupture → crust formation. (vetstream.com)
  • At day 4pi, animals C1V1 and C2V2 had acanthosis, mild multifocal acantholysis and moderate focal hyperkeratosis, with focally extensive loss of epidermal layers (ulcer) and focally extensive necrosis with intralesional aggregate of basophilic coccoid bacteria (Figure 2A e 2C). (thefreedictionary.com)
  • Protease release → intercellular cement breakdown → cell detachment and acantholysis (loss of cohesion between epidermal cells). (vetstream.com)
  • The benign mucosa may show spongiosis, acantholysis , degeneration, and reactive atypia that mimic carcinoma or dysplasia. (thefreedictionary.com)
  • Focal epidermal necrosis, acanthosis ballooning degeneration, and acantholysis of keratinocytes were observed. (thefreedictionary.com)
  • This is an uncommon and rare histopathologic variant of SCC, characterised by acantholysis of the tumour cells, creating pseudo lumina and false appearance of glandular differentiation. (thefreedictionary.com)
  • The term acantholysis refers to degeneration of the malpighian cells in which the intercellular fibrils diappear and the cells assume a spherical shape with swelling of the nuclei and condensation of the cytoplasm at the periphery. (hubpages.com)
  • He is member of the Maintenance Team of the IEC/EN 60335-2-27 Standard, Member of the WHO ICD11 Dermatology Topic Advisory Group, and Member of several Committees of the Australasian College of Dermatologists (Scientific Research, Scientific Advisory, Academic, and MBS Committees). (edu.au)
  • This graph shows the total number of publications written about "Acantholysis" by people in Harvard Catalyst Profiles by year, and whether "Acantholysis" was a major or minor topic of these publication. (harvard.edu)
  • In addition to pigmentation changes, individuals with Galli-Galli disease also have a breakdown of cells in the outer layer of skin (acantholysis). (medlineplus.gov)