Acanthamoeba Keratitis: Infection of the cornea by an ameboid protozoan which may cause corneal ulceration leading to blindness.Acanthamoeba: A genus of free-living soil amoebae that produces no flagellate stage. Its organisms are pathogens for several infections in humans and have been found in the eye, bone, brain, and respiratory tract.Keratitis: Inflammation of the cornea.Acanthamoeba castellanii: A species of free-living soil amoebae in the family Acanthamoebidae. It can cause ENCEPHALITIS and KERATITIS in humans.Contact Lenses: Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)Amebicides: Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.Amebiasis: Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.Contact Lens Solutions: Sterile solutions used to clean and disinfect contact lenses.Contact Lenses, Hydrophilic: Soft, supple contact lenses made of plastic polymers which interact readily with water molecules. Many types are available, including continuous and extended-wear versions, which are gas-permeable and easily sterilized.Corneal Ulcer: Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)BiguanidesAmoeba: A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several lodopodia, one of which is dominant at a given time. Reproduction occurs asexually by binary fission.Benzamidines: Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.Keratoplasty, Penetrating: Partial or total replacement of all layers of a central portion of the cornea.Eye Infections, Parasitic: Mild to severe infections of the eye and its adjacent structures (adnexa) by adult or larval protozoan or metazoan parasites.RNA, Ribosomal, 18S: Constituent of the 40S subunit of eukaryotic ribosomes. 18S rRNA is involved in the initiation of polypeptide synthesis in eukaryotes.Keratitis, Herpetic: A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)Keratitis, Dendritic: A form of herpetic keratitis characterized by the formation of small vesicles which break down and coalesce to form recurring dendritic ulcers, characteristically irregular, linear, branching, and ending in knoblike extremities. (Dictionary of Visual Science, 3d ed)Eye Infections, Fungal: Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.Antiprotozoal Agents: Substances that are destructive to protozoans.Eye Infections, Bacterial: Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.Contact Lenses, Extended-Wear: Hydrophilic contact lenses worn for an extended period or permanently.Methylmannosides: Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.DNA, Protozoan: Deoxyribonucleic acid that makes up the genetic material of protozoa.Disinfectants: Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)Epithelium, Corneal: Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Hygiene: The science dealing with the establishment and maintenance of health in the individual and the group. It includes the conditions and practices conducive to health. (Webster, 3d ed)Cricetulus: A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.Conjunctiva: The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.Mannose: A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)Eye Infections: Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.
(1/141) In vivo tandem scanning confocal microscopy in acanthamoeba keratitis.

The in vivo confocal microscopy technique provides us with a real-time, non-invasive way of examining the human cornea. The most important advantage of this type of microscopy is to reveal the etiologic agents in infectious keratitis such as Acanthamoeba keratitis. We present several representative cases of Acanthamoeba keratitis, which were diagnosed in their early stages using in vivo confocal microscopy and managed based on that diagnosis. In our Acanthamoeba keratitis cases, highly-reflective round or ovoid organisms with a diameter of about 10-25 um were visualized distinctly against relatively-dark normal parenchymal structures, such as epithelial cells or keratocyte nuclei. Double-walled structures of Acanthamoeba cysts were clearly demonstrated in some cases. We can confirm that in vivo tandem scanning confocal microscopy is a powerful diagnostic tool for identifying the infecting organisms in Acanthamoeba keratitis.  (+info)

(2/141) Corneal ulceration in the elderly in Hyderabad, south India.

AIMS: To report demographic, microbiological, therapeutic, anatomical, and visual results of corneal ulceration in the elderly patients seen at a tertiary eye care centre in south India. METHODS: 102 consecutive cases of microbial keratitis in patients 65 years and older were studied. Inclusion criteria were: (i) presence of corneal stromal infiltrate upon slit lamp examination; and (ii) microbiological evaluation of corneal scrapings for suspected microbial keratitis. RESULTS: The principal predisposing factors identified in this study were ocular disease (38.2%), previous ocular surgery in the same eye (29.4%), trauma (17.6%), and severe systemic disease (16.7%). Contact lens wear was associated with only two cases (2.0%). 99 organisms were isolated in cultures of corneal scrapings from 74 (72.5%) of the 102 cases. Staphylococcus epidermidis (31.1%), filamentous fungi (25.7%), and Streptococcus pneumoniae (13.5%) were the most common isolates. 12 eyes (11.8%) required surgery, 15 (14.7%) eventually required evisceration, and nine (9.6%) of the 94 followed patients achieved an unaided vision of 20/60 or better at last follow up. CONCLUSIONS: This work represents the largest recent single centre study on (non-viral) microbial keratitis in the elderly, its management, and outcomes of therapy. While the predisposing factors differ from those of general population, the spectrum of microbes responsible for keratitis in the elderly appears to reflect the local microbial flora rather than a predilection for elderly patients. Delay in diagnosis and systemic conditions associated with advancing age probably contribute to poorer outcome from therapeutic measures.  (+info)

(3/141) Random amplified polymorphic DNA profiles as a tool for the characterization of Brazilian keratitis isolates of the genus Acanthamoeba.

The genus Acanthamoeba comprises free-living amebae identified as opportunistic pathogens of humans and other animal species. Morphological, biochemical and molecular approaches have shown wide genetic diversity within the genus. In an attempt to determine the genetic relatedness among isolates of Acanthamoeba we analyzed randomly amplified polymorphic DNA (RAPD) profiles of 11 Brazilian isolates from cases of human keratitis and 8 American type culture collection (ATCC) reference strains. We found that ATCC strains belonging to the same species present polymorphic RAPD profiles whereas strains of different species show very similar profiles. Although most Brazilian isolates could not be assigned with certainty to any of the reference species, they could be clustered according to pattern similarities. The results show that RAPD analysis is a useful tool for the rapid characterization of new isolates and the assessment of genetic relatedness of Acanthamoeba spp. A comparison between RAPD analyses and morphological characteristics of cyst stages is also discussed.  (+info)

(4/141) Isoenzyme patterns and phylogenetic relationships in Acanthamoeba spp. isolated from contact lens containers in Korea.

In order to refer to the basic information regarding the identification of isolates obtained from a contact lens container in Korea, the isoelectric focusing gel electrophoresis was employed to compare the isoenzyme band patterns among Acanthamoeba spp. including eight isolates and the simple pairwise dissimilarity analysis was carried out. For an alkaline phosphate development, isolate 7 and Acanthamoeba polyphaga showed homologous band patterns, and isolates 1, 2, and 3 showed the same patterns. For lactate dehydrogenase, similar patterns were observed in isolates 2 and 3. Isolates 3 and 5 showed homologous band patterns for malate dehydrogenase and glucose phosphate isomerase. For hexokinase, isolates 4, 7, and A, hatchetti showed the same band patterns. In others, a considerable number of interstrain polymorphisms was observed in nine isoenzyme band patterns. In Acanthamoeba group II, genetic distances among isolates 1, 2, 3, 4, and 5 ranged from 0.104 to 0.200. In comparison to A. castellanii, A. hatchetti, and A. polyphaga, genetic distances of isolates 7 and 8 were 0.254 and 0.219, respectively. In Acanthamoeba group III, including A. culbertsoni, A. healyi, and A. royreba, isolate 6 had genetic distances which ranged from 0.314 to 0.336. Finally, when comparing to the six reference Acanthamoeba, it was possible to classify isolates 1, 2, 3, 4, and 5, as genetically close-related species and as independent species group. Furthermore, isolates 6, 7 and 8 were identified as independent species as well.  (+info)

(5/141) Unusual case of Acanthamoeba polyphaga and Pseudomonas aeruginosa keratitis in a contact lens wearer from Gauteng, South Africa.

Acanthamoeba species can cause a chronic, progressive ulcerative keratitis of the eye which is not responsive to the usual antimicrobial therapy and is frequently mistaken for stromal herpes keratitis. An unusual case of coinfection with Acanthamoeba polyphaga and Pseudomonas aeruginosa as causes of corneal keratitis in a contact lens wearer from Gauteng, South Africa, is reported. These two pathogens have previously been assumed to be selectively exclusive. Cysts of the isolated acanthameba tolerated an incubation temperature of 40 degrees C, indicating a pathogenic species. This case highlights the importance of culture methods in the diagnosis of corneal infection and the choice of treatment regimen. The patient's history of careless contact lens-disinfecting habits emphasizes the need to adhere strictly to recommended methods of contact lens care.  (+info)

(6/141) Acanthamoeba keratitis.

Acanthamoeba keratitis, common in soft lens wearers, is not commonly isolated. The reports of Acanthamoeba keratitis in Indian literature are few. We report here a case of Acanthamoeba Keratitis in a medical student using soft contact lenses, initially diagnosed and treated as a bacterial and later as a viral corneal ulcer, who responded extremely well to medical line of therapy.  (+info)

(7/141) Phylogenetic diversity among geographically dispersed Chlamydiales endosymbionts recovered from clinical and environmental isolates of Acanthamoeba spp.

The recently proposed reorganization of the order Chlamydiales and description of new taxa are broadening our perception of this once narrowly defined taxon. We have recovered four strains of gram-negative cocci endosymbiotic in Acanthamoeba spp., representing 5% of the Acanthamoeba sp. isolates examined, which displayed developmental life cycles typical of members of the Chlamydiales. One of these endosymbiont strains was found stably infecting an amoebic isolate recovered from a case of amoebic keratitis in North America, with three others found in acanthamoebae recovered from environmental sources in North America (two isolates) and Europe (one isolate). Analyses of nearly full-length 16S rRNA gene sequences of these isolates by neighbor joining, parsimony, and distance matrix methods revealed their clustering with other members of the Chlamydiales but in a lineage separate from those of the genera Chlamydia, Chlamydophila, Simkania, and Waddlia (sequence similarities, <88%) and including the recently described species Parachlamydia acanthamoebae (sequence similarities, 91.2 to 93.1%). With sequence similarities to each other of 91.4 to 99.4%, these four isolates of intra-amoebal endosymbionts may represent three distinct species and, perhaps, new genera within the recently proposed family Parachlamydiaceae. Fluorescently labeled oligonucleotide probes targeted to 16S rRNA signature regions were able to readily differentiate two groups of intra-amoebal endosymbionts which corresponded to two phylogenetic lineages. These results reveal significant phylogenetic diversity occurring among the Chlamydiales in nontraditional host species and supports the existence of a large environmental reservoir of related species. Considering that all described species of Chlamydiales are known to be pathogenic, further investigation of intra-amoebal parachlamydiae as disease-producing agents is warranted.  (+info)

(8/141) Heterogeneity in cyst morphology within isolates of Acanthamoeba from keratitis patients in Thailand.

We isolated Acanthamoebae from the first two keratitis patients identified in Thailand in 1988 and 1990. The patients developed decreased vision, severe photophobia, severe eye pain and foreign body sensation after minor corneal trauma. The lesions included generalized superficial punctate keratitis, stromal corneal ulcer with keratic precipitate and uveitis in one case, and corneal ulcer with abscess in the other. Both cases were diagnosed by isolation of characteristic trophozoites and cysts of Acanthamoeba from corneal tissue by non-nutrient agar culture method. Based on cyst morphology, A. castellanii and A. polyphaga were detected in one case, and A. castellanii and A. triangularis in the other. Restriction fragment length polymorphism analysis of mitochondrial DNA (mtDNA-RFLP) revealed that each patient harboured a single parasite population. One shared mtDNA-RFLP with an authentic strain of A. castellanii, and the other gave a new unique pattern. Thus species identification of Acanthamoeba based on cyst morphology per se can be arbitrary, and mtDNA-RFLP may be more appropriate for accurate species/strain differentiation amongst morphologically heterogeneous populations of Acanthamoebae.  (+info)

*  Fungal contamination of contact lenses
Gray, Trevor B; Ray T M Cursons; Jane F Sherwan; Paul R Rose (1995). "Acanthamoeba, bacterial, and fungal contamination of ... For the treatment for filamentous fungal keratitis, "topical natamycin is usually the first choice." For the treatment of yeast ... In the study In Vitro Interactions of Fusarium and Acanthamoeba with Drying Residues of Multipurpose Contact Lens Solutions, ... and keratitis, "medical therapy alone" is usually not enough to treat the infections due to the invasive nature of certain ...
*  Abbott Medical Optics
The solution has been linked to cases of an eye infection (keratitis) caused by an organism of the genus Acanthamoeba. The ... In May 2007, the Centers for Disease Control and Prevention linked AMO MoisturePlus eye solution to Acanthamoeba keratitis ... including eye infection and microbial keratitis. The voluntary and limited recall was caused by an isolated production line ... Company was sued in June 2007 by Michael Connolly, who claimed to have developed a keratitis infection after using AMO's ...
*  Corneal ulcer
Protozoa infection like Acanthamoeba keratitis is characterized by severe pain and is associated with contact lens users ... Small satellite lesions around the ulcer are a common feature of fungal keratitis and hypopyon is usually seen. Viral keratitis ... Fungal keratitis causes deep and severe corneal ulcer. It is caused by Aspergillus sp., Fusarium sp., Candida sp., as also ... The typical feature of fungal keratitis is slow onset and gradual progression, where signs are much more than the symptoms. ...
*  Acanthamoeba
... - Centers for Disease Control and Prevention Video of Acanthamoeba from contact lens keratitis Marciano-Cabral F, ... there are currently no good diagnoses or treatments for Acanthamoeba infection. Acanthamoeba keratitis cases in the past, when ... Acanthamoeba infection Acanthamoeba keratitis Balamuthia mandrillaris Granulomatous amoebic encephalitis Legionella Marciano- ... Diseases caused by Acanthamoeba include keratitis and granulomatous amoebic encephalitis (GAE). The latter is often but not ...
*  Polyhexanide
PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, it also has an ... "Medical interventions for acanthamoeba keratitis". Cochrane Database Syst Rev. 2: CD0010792. doi:10.1002/14651858.CD010792.pub2 ...
*  Acanthamoeba keratitis
... FAQs". Cdc.gov. Retrieved 2013-08-02. Auran, JD; Starr MB; Jakobiec FA (1987). "Acanthamoeba keratitis. ... Acanthamoeba keratitis - Centers for Disease Control and Prevention Picture reference of the life cycle of Acanthamoeba. ... "Acanthamoeba-General Information-Acanthamoeba keratitis". CDC. "Free-living Amebic Infections". CDC. Pasricha, Gunisha; Savitri ... Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in permanent visual ...
*  Emil Chynn
Acanthamoeba keratitis: is water exposure a true risk factor? CLAO. 23(1): 55-56, 1997. First article published on CLAO's ... Chynn, E. W.; Talamo, J. H.; Seligman, M. S. (January 1997). "Acanthamoeba keratitis: is water exposure a true risk factor?". ... Acanthamoeba keratitis: contact lens and non-contact lens characteristics. Ophthalmology. 102: 1369-1373, 1995. Chynn EW, ... Chynn, E. W.; Lopez, M. A.; Pavan-Langston, D.; Talamo, J. H. (September 1995). "Acanthamoeba keratitis. Contact lens and ...
*  Chlorhexidine
... eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Chlorhexidine does not meet ... Alkharashi M, Lindsley K, Law HA, Sikder S (2015). "Medical interventions for acanthamoeba keratitis". Cochrane Database Syst ...
*  Buffered charcoal yeast extract agar
It has also been used for the recovery of Acanthamoeba keratitis. "Archived copy" (PDF). Archived from the original (PDF) on ... Penland RL, Wilhelmus KR (October 1998). "Laboratory diagnosis of Acanthamoeba keratitis using buffered charcoal-yeast extract ...
*  Acanthamoeba infection
Acanthamoeba strains can also infect human eyes causing acanthamoebic keratitis. Acanthamoeba keratitis Balamuthia infection ... Acanthamoeba infection is a cutaneous condition resulting from Acanthamoeba that may result in various skin lesions. ... ISBN 1-4160-2999-0. Khan, Naveed Ahmed (2009). Acanthamoeba: Biology and Pathogenesis. Horizon Scientific Press. p. 127. ISBN ...
*  Amoebiasis
at Orphanet "EyeRounds.org:Acanthamoeba Keratitis: 39-year-old contact lens wearer with persisting keratitis & pain". Archived ... which causes cutaneous amoebiasis and Acanthamoeba keratitis Balamuthia mandrillaris, which causes granulomatous amoebic ... Visvesvara GS, Moura H, Schuster FL (June 2007). "Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., ... Naegleria fowleri, which causes primary amoebic meningoencephalitis Acanthamoeba, ...
*  Miltefosine
It has orphan drug status in the United States for acanthamoeba keratitis and primary amebic meningoencephalitis (PAM). It is ... for the treatment of Acanthamoeba Keratitis with miltefosine". www.prnewswire.com. Archived from the original on 2016-12-21. ... Swiatlo, E; Henderson, H; Zamora, A (2014). "Acanthamoeba encephalitis: A Case Report and Review of Therapy". Surgical ... and Acanthamoeba. However, later studies showed that it is not as potent as other drugs, such as chlorpromazine and diminazene ...
*  Perimycin
"Polymicrobial Keratitis: Acanthamoeba and Infectious Crystalline Keratopathy". American Journal of Ophthalmology. 148 (1): 13- ...
*  Keratitis
On May 25, 2007, the CDC issued a health advisory due to increased risk of Acanthamoeba keratitis (AK) associated with use of ... Acute epithelial keratitis Nummular keratitis Interstitial keratitis Disciform keratitis Neurotrophic keratitis Mucous plaque ... Superficial punctate keratitis Ulcerative keratitis Exposure keratitis (also known as exposure keratopathy)- due to dryness of ... Fungal keratitis (cf. Fusarium, causing an outbreak of keratitis in 2005-2006 through the possible vector of Bausch & Lomb ReNu ...
*  Momus (musician)
In December 1997, he contracted acanthamoeba keratitis in his right eye due to a contact lens mishap sustained whilst on ...
*  Cutaneous amoebiasis
Acanthamoeba Keratitis: 39-year-old contact lens wearer with persisting keratitis & pain". Retrieved 2009-01-17. Walia R, ... It can be caused by Acanthamoeba or Entamoeba histolytica. When associated with Acanthamoeba, it is also known as "cutaneous ... Montoya JG, Visvesvera GS, Booton GC, Doyle RL (March 2007). "A case of successful treatment of cutaneous Acanthamoeba ...
*  Topical anesthetic
... masquerading as acanthamoeba keratitis or other infectious keratitis. When a keratitis is unresponsive to treatment and ... July 1997). "Topical anesthetic abuse ring keratitis: report of four cases". Cornea. 16 (4): 424-9. doi:10.1097/00003226- ... "Corneal anesthetic abuse and Candida keratitis". Ophthalmology. 103 (1): 37-40. doi:10.1016/s0161-6420(96)30735-5. PMID 8628558 ... challenges for correct diagnosis in that it is a relatively uncommon entity that may initially present as a chronic keratitis, ...
*  Protozoa
... acanthamoeba keratitis, and primary amoebic meningoencephalitis (naegleriasis). The protozoan Ophryocystis elektroscirrha is a ...
*  Human parasite
... causes Toxoplasmosis Acanthamoeba: causes Acanthamoeba keratitis Leishmania: causes Leishmaniasis Babesia: causes Babesiosis ...
*  Orthokeratology
1 March 2004 Acanthamoeba keratitis and overnight orthokeratology Case presentation: Canadian Adverse Reaction Newsletter ... The Globe and Mail reported two cases in Canada in which Acanthamoeba infections during ortho-k treatment, possibly related to ...
*  List of MeSH codes (C11)
... acanthamoeba keratitis MeSH C11.204.564.225 --- corneal ulcer MeSH C11.204.564.425 --- keratitis, herpetic MeSH C11.204.564.425 ... acanthamoeba keratitis MeSH C11.294.725.562 --- onchocerciasis, ocular MeSH C11.294.725.781 --- toxoplasmosis, ocular MeSH ... keratitis, herpetic MeSH C11.294.800.475.450 --- keratitis, dendritic MeSH C11.319.217 --- conjunctival neoplasms MeSH C11.319. ... keratitis, dendritic MeSH C11.204.564.585 --- keratoconjunctivitis MeSH C11.204.564.585.500 --- keratoconjunctivitis, ...
*  List of MeSH codes (C03)
... acanthamoeba keratitis MeSH C03.752.700.700.055.250 --- blastocystis infections MeSH C03.752.700.700.055.328 --- dysentery, ...
*  Amoeba
Acanthamoeba can cause amoebic keratitis and encephalitis in humans. Balamuthia mandrillaris is the cause of (often fatal) ... This finding suggests that the ''Acanthamoeba'' are capable of some form of meiosis and may be able to undergo sexual ... "Acanthamoeba , Microworld". www.arcella.nl. Retrieved 2016-08-21. "Microscopy of Entamoeba histolytica". msu.edu. Retrieved ... Orthologs of genes employed in meiosis of sexual eukaryotes have recently been identified in the Acanthamoeba genome. These ...
*  Antiparasitic
Kusrini E, Hashim F, Azmi WN, Amin NM, Estuningtyas A (2016). "A novel antiamoebic agent against Acanthamoeba sp. - A causative ... agent for eye keratitis infection". Spectrochim Acta A Mol Biomol Spectrosc. 153: 714-21. doi:10.1016/j.saa.2015.09.021. PMID ...
*  Kaempferia galanga
It was also found to be effective as an amebicide in vitro against three species of Acanthamoeba, which cause granulomatous ... amebic encephalitis and amebic keratitis. In 1999, the rhizome extract was found to inhibit activity of Epstein-Barr virus. ...
*  Pandoravirus
Unlike in other cases with such giant viruses, the large particles within Acanthamoebae were not mistaken for bacteria. The ... in an amoeba living in the contact lens of a woman with keratitis. Its development within the amoebal host was documented ... Scheid P, Hauröder B, Michel R (2010). "Investigations of an extraordinary endocytobiont in Acanthamoeba sp.: development and ...
*  Naegleria fowleri
Acanthamoeba - an amoeba that can cause amoebic keratitis and encephalitis in humans Entamoeba histolytica - an amoeba that is ... as a structural homolog of animal CHRM1 has been shown to be present in Naegleria and Acanthamoeba. It takes 1-9 days (average ...
Kerala Government Optometrists Association | Acanthamoeba Keratitis Who, why, where and what to do? | Industry Specialist  Kerala Government Optometrists' Association | Acanthamoeba Keratitis Who, why, where and what to do? | Industry Specialist
... diagnosis and treatment of Acanthamoeba Keratitis. It will also highlight key areas of research that offer hope for sufferers. ... Acanthamoeba Keratitis is a devastating eye infection which in developed countries most commonly occurs in contact lens wearers ... Acanthamoeba Keratitis Who, why, where and what to do?. Acanthamoeba Keratitis Who, why, where and what to do?. ... Acanthamoeba Keratitis is a devastating eye infection which in developed countries most commonly occurs in contact lens wearers ...
more infohttps://www.wcea.education/app/goak/elearning/optometrist/kerala-government-optometrists-association/176796/acanthamoeba-keratitis-who-why-where-and-what-to-do
Douglas County Issues Contact Lens Solution Warning | EmaxHealth  Douglas County Issues Contact Lens Solution Warning | EmaxHealth
AMO Complete MoisturePlus Multipurpose Contact Lens solution has been linked to Acanthamoeba keratitis, an infection caused by ...
more infohttps://www.emaxhealth.com/96/15354.html
Looking Good: Safe Use and Care of Contact Lenses  Looking Good: Safe Use and Care of Contact Lenses
An outbreak of Acanthamoeba keratitis occurred in 2007; this is another rare but serious eye infection caused by a parasite ... In 2006, there was an outbreak of Fusarium keratitis, which is a rare but serious eye infection caused by a fungus. The ... Contact lens wearers represent 90% of A. keratitiscases. It is estimated that the U.S. incidence of this infection is between ... The unexpected keratitis outbreaks prompted FDA to explore the various risk factors involved with using multipurpose contact ...
more infohttp://www.pharmjobs.org/2010/12/looking-good-safe-use-and-care-of.html
All About Contact Lens Care Products  All About Contact Lens Care Products
... when it was implicated by the CDC in cases of Acanthamoeba keratitis). The function of these multipurpose contact lens ... 2006 when it was implicated by the CDC in cases of fungal keratitis, and AMO's COMPLETE® Moisture PLUS™ was recalled May 25th, ...
more infohttp://1800myeyedoc.com/all-about-contact-lens-care-products1.html
Acanthamoeba keratitis  Acanthamoeba keratitis
... may be limited to the epithelium in its early stages, resulting in epithelial dendrites and punctate ... Acanthamoeba keratitis Acanthamoeba keratitis is a rare parasitic infection of the cornea that primarily occurs in contact lens ... See the related article for more information on Acanthamoeba keratitis. *Coming soon: 'The treatment of Acanthamoeba' in ... Figure 5: 300x magnification of the corneal epithelium in a patient with Acanthamoeba keratitis. H&E stain demonstrates a ...
more infohttp://webeye.ophth.uiowa.edu/eyeforum/atlas/pages/acanthamoeba/index.htm
Acanthamoeba keratitis: a review.  - PubMed - NCBI  Acanthamoeba keratitis: a review. - PubMed - NCBI
Acanthamoeba keratitis: a review.. Claerhout I1, Kestelyn P.. Author information. 1. Department of Ophthalmology, University ... Acanthamoeba keratitis is caused by protozoa and characterised by a protracted course. All patients presenting with a therapy- ... resistant keratitis, even non-contact lens wearers, should be examined for the presence of Acanthamoeba by means of specific ... Acanthamoeba Keratitis/diagnosis*. *Acanthamoeba Keratitis/epidemiology. *Acanthamoeba Keratitis/etiology. *Acanthamoeba ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10670164
Acanthamoeba Keratitis Treatment - American Academy of Ophthalmology  Acanthamoeba Keratitis Treatment - American Academy of Ophthalmology
Unfortunately, treatment of well-established Acanthamoeba keratitis remains frustr ... Early treatment of Acanthamoeba keratitis reduces long-term visual sequelae. ... Seal D. Treatment of Acanthamoeba keratitis. Expert Rev Anti Infect Ther. 2003;1:205-208.. 2.. Perez-Santonja JJ, Kilvington S ... Persistently culture positive Acanthamoeba keratitis: in vivo resistance and in vitro sensitivity. Ophthalmology. 2003;110:1593 ...
more infohttps://www.aao.org/current-insight/acanthamoeba-keratitis-treatment
Acanthamoeba Keratitis Treatment & Symptoms | CooperVision  Acanthamoeba Keratitis Treatment & Symptoms | CooperVision
Information about acanthamoeba keratitis, its treatment and symptoms can be found at CooperVision. Reduce your chances of being ... What are the symptoms of Acanthamoeba keratitis?. Symptoms of Acanthamoeba keratitis include the following:. *Sensitivity to ... What can I do to help reduce the chances of contracting Acanthamoeba keratitis?. A trauma to the cornea (the clear dome that ... Infection of Acanthamoeba keratitis could happen through cuts or other eye traumas; exposure to contaminated water; or poor ...
more infohttps://coopervision.com/eye-health-and-vision/acanthamoeba-keratitis
Advances in the Diagnosis and Treatment of Acanthamoeba Keratitis  Advances in the Diagnosis and Treatment of Acanthamoeba Keratitis
P. R. Badenoch, "The pathogenesis of Acanthamoeba keratitis," Australian and New Zealand Journal of Ophthalmology, vol. 19, no ... C. D. Illingworth and S. D. Cook, "Acanthamoeba keratitis," Survey of Ophthalmology, vol. 42, no. 6, pp. 493-508, 1998. View at ... D. A. Schaumberg, K. K. Snow, and M. R. Dana, "The epidemic of Acanthamoeba keratitis: where do we stand?" Cornea, vol. 17, no ... Advances in the Diagnosis and Treatment of Acanthamoeba Keratitis. Benjamin Clarke, Arti Sinha, Dipak N. Parmar, and Evripidis ...
more infohttps://www.hindawi.com/journals/joph/2012/484892/ref/
Eye - Cornea - Acanthamoeba keratitis  Eye - Cornea - Acanthamoeba keratitis
Fungal or herpetic keratitis End of Eye > Cornea > Acanthamoeba keratitis. This information is intended for physicians and ... Acanthamoeba keratitis. Reviewer: Nat Pernick, M.D. (see Reviewers page). Revised: 6 October 2013, last major update February ...
more infohttp://www.pathologyoutlines.com/topic/eyecorneaacanthamoeba.html
Contact Lens Solution Recalled Over Link With Acanthamoeba Keratitis | Medpage Today  Contact Lens Solution Recalled Over Link With Acanthamoeba Keratitis | Medpage Today
Acanthamoeba keratitis, which primarily affects otherwise healthy people who wear contact lenses, may lead to vision loss, with ... The symptoms of difficult-to-treat.Acanthamoeba keratitis can be similar to those of other more common eye infections and may ... According to the CDC, Acanthamoeba keratitis infections occur in approximately two of every one million contact lens users in ... Following reports of a possible increased risk of Acanthamoeba keratitis among soft contact lens wearers who used Complete ...
more infohttps://www.medpagetoday.com/surgery/ophthalmology/5786
First cases of Acanthamoeba keratitis in Slovakia.	
	  First cases of Acanthamoeba keratitis in Slovakia.
For the first time, Acanthamoeba sp. GroupIII was isolated from a 53-year-old patient with keratitis, which was manifested ... We present the case report of the first identification of Acanthamoebaas a causative agent of keratitis in the Slovak Republic ... Acanthamoeba Keratitis - pathology, Acanthamoeba Keratitis - surgery, Contact Lenses - adverse effects, Contact Lenses - ... For the first time, Acanthamoeba sp. GroupIII was isolated from a 53-year-old patient with keratitis, which was manifested ...
more infohttp://www.aaem.pl/First-cases-of-Acanthamoeba-keratitis-in-Slovakia-,72903,0,2.html
Acanthamoeba Keratitis:  Are Recent Cases More Severe?  Acanthamoeba Keratitis: Are Recent Cases More Severe?
To identify a recent change in disease severity and visual outcomes of patients with Acanthamoeba keratitis (AK) at Wills Eye ... Currently, we are treating older patients with more severe keratitis who are presenting later and with worse vision compared ...
more infohttps://insights.ovid.com/crossref?an=00003226-201811000-00008
Acanthamoeba keratitis - Wikipedia  Acanthamoeba keratitis - Wikipedia
Acanthamoeba Keratitis FAQs". Cdc.gov. Retrieved 2013-08-02. Auran, JD; Starr MB; Jakobiec FA (1987). "Acanthamoeba keratitis. ... Acanthamoeba keratitis - Centers for Disease Control and Prevention Picture reference of the life cycle of Acanthamoeba. ... "Acanthamoeba-General Information-Acanthamoeba keratitis". CDC. "Free-living Amebic Infections". CDC. Pasricha, Gunisha; Savitri ... Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in permanent visual ...
more infohttps://en.wikipedia.org/wiki/Acanthamoeba_keratitis
Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis | springermedizin.at  Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis | springermedizin.at
... has been reported as a rare sight-threatening manifestation of prolonged severe Acanthamoeba ... Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis. Case report of a patient with Sjögren's ... Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis. Case report of a patient with Sjögren's ... We report on a case of Acanthamoeba keratitis (AK)-related reactive ischemic posterior segment inflammation following ...
more infohttps://www.springermedizin.at/severe-reactive-ischemic-posterior-segment-inflammation-in-acant/14917990
Laboratory Culture Positivity in Patients With Suspected Acanthamoeba Keratitis | IOVS | ARVO Journals  Laboratory Culture Positivity in Patients With Suspected Acanthamoeba Keratitis | IOVS | ARVO Journals
Laboratory Culture Positivity in Patients With Suspected Acanthamoeba Keratitis M. L. Ribeiro; P. V. Ferrari; F. Hirai; M. ... Laboratory Culture Positivity in Patients With Suspected Acanthamoeba Keratitis You will receive an email whenever this article ... Laboratory Culture Positivity in Patients With Suspected Acanthamoeba Keratitis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2426 ... positivity of microbiological results of corneal scrapings collected from patients suspected of having Acanthamoeba keratitis ( ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2371093
Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification | IOVS | ARVO Journals  Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification | IOVS | ARVO Journals
The LAMP assay is a simple, rapid, highly specific and sensitive method for the diagnosis of keratitis caused by Acanthamoeba. ... Ge Zhao, Qing Yuan; Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification. Invest. ... Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification ... Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification ...
more infohttp://iovs.arvojournals.org/article.aspx?articleid=2147634
Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications | British Journal...  Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications | British Journal...
Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications ... Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications ...
more infohttps://bjo.bmj.com/content/102/10/1431.altmetrics
FDA Video: Contact Lens Safety | Acanthamoeba Keratitis & Contact Lens Solution Lawsuit, Attorney, Lawyer, Law Firm  FDA Video: Contact Lens Safety | Acanthamoeba Keratitis & Contact Lens Solution Lawsuit, Attorney, Lawyer, Law Firm
If you or somebody you know has used AMO Complete MoisturePlus and developed Acanthamoeba Keratitis, you should contact our ... published an informative video regarding contact lens safety and Acanthamoeba Keratitis which we have included below. ... accepting claims in all 50 states for those who used AMO Complete MoisturePlus and have developed Acanthamoeba Keratitis. ...
more infohttps://www.schmidtlaw.com/fda-video-contact-lens-safety/
Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach | Parasites & Vectors | Full Text  Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach | Parasites & Vectors | Full Text
Panjwani N. Pathogenesis Of Acanthamoeba keratitis. Ocul Surf. 2010;8(2):70-9.View ArticlePubMedPubMed CentralGoogle Scholar. ... Anti-Acanthamoeba activity of different artificial tears used in the treatment of amoeba keratitis. In: VII European Congress ... Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom. Invest Ophthalmol Vis Sci. 2004;45( ... Acanthamoeba keratitis: a 12-year experience covering a wide spectrum of presentations, diagnoses, and outcomes. J Ophthalmol. ...
more infohttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2639-5
Lecture: Acanthamoeba Keratitis: A Case Study for Outbreak Investigations - Cybersight  Lecture: Acanthamoeba Keratitis: A Case Study for Outbreak Investigations - Cybersight
... we describe an ongoing outbreak of Acanthamoeba keratitis in the United States and the process of investigating, identifying ... if you choose to use them to treat acanthamoeba in the future. So as far as voriconazole and acanthamoeba keratitis, this was ... is really to suspect the possibility of acanthamoeba keratitis. So in a patient who has herpetic keratitis, for example, or ... the first thing that you should think about is acanthamoeba keratitis. Whether it be an epithelialopathy or a stromal keratitis ...
more infohttps://cybersight.org/portfolio/lecture-acanthamoeba-keratitis-a-case-study-for-outbreak-investigations/
Acanthamoeba Keratitis & Contact Lenses | Prevent Blindness  Acanthamoeba Keratitis & Contact Lenses | Prevent Blindness
How rare is acanthamoeba keratitis?. Acanthamoeba keratitis is extremely rare in the United States. It was first recognized in ... What is acanthomoeba keratitis?. Acanthamoeba keratitis is a severe, painful infection of the cornea, the transparent outer ... Prevent Blindness and acanthamoeba keratitis research:. Dr. Charlotte Joslin, at the University of Illinois-Chicago has been ... She received her first Prevent Blindness Investigator award in 2006 for her study, "Chicago-area Acanthamoeba Keratitis." In ...
more infohttp://eyesummit.preventblindness.org/acanthamoeba-keratitis-and-contact-lenses
Pathogenesis of Acanthamoeba Keratitis - Noorjahan Panjwani  Pathogenesis of Acanthamoeba Keratitis - Noorjahan Panjwani
... and intensely painful infection of the cornea caused by parasites of the genus Acanthamoeba. At present,... ... Pathogenesis of Acanthamoeba Keratitis Panjwani, Noorjahan Tufts University, Boston, MA, United States ... Acanthamoeba keratitis (AK) is a serious, debilitating, and intensely painful infection of the cornea caused by parasites of ... 2015) IL-17A-mediated protection against Acanthamoeba keratitis. J Immunol 194:650-63 ...
more infohttp://grantome.com/grant/NIH/R01-EY009349-13
Acanthamoeba Keratitis & Contact Lenses | Prevent Blindness Ohio  Acanthamoeba Keratitis & Contact Lenses | Prevent Blindness Ohio
How rare is acanthamoeba keratitis?. Acanthamoeba keratitis is extremely rare in the United States. It was first recognized in ... What is acanthomoeba keratitis?. Acanthamoeba keratitis is a severe, painful infection of the cornea, the transparent outer ... Prevent Blindness and acanthamoeba keratitis research:. Dr. Charlotte Joslin, at the University of Illinois-Chicago has been ... She received her first Prevent Blindness Investigator award in 2006 for her study, "Chicago-area Acanthamoeba Keratitis." In ...
more infohttps://ohio.preventblindness.org/acanthamoeba-keratitis-and-contact-lenses
Acanthamoeba Keratitis & Contact Lenses | Childrens Vision Massachusetts  Acanthamoeba Keratitis & Contact Lenses | Children's Vision Massachusetts
How rare is acanthamoeba keratitis?. Acanthamoeba keratitis is extremely rare in the United States. It was first recognized in ... What is acanthomoeba keratitis?. Acanthamoeba keratitis is a severe, painful infection of the cornea, the transparent outer ... Prevent Blindness and acanthamoeba keratitis research:. Dr. Charlotte Joslin, at the University of Illinois-Chicago has been ... She received her first Prevent Blindness Investigator award in 2006 for her study, "Chicago-area Acanthamoeba Keratitis." In ...
more infohttps://childrensvision.preventblindness.org/acanthamoeba-keratitis-and-contact-lenses
  • Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. (wikipedia.org)
  • All of the plaintiffs allege that they contracted Acanthamoeba infections while they were using Complete® MoisturePlus™ to disinfect their contact lenses. (schmidtandclark.com)
  • Acanthamoeba infections can be chronic, resistant to treatment, and often require surgical interventions such as corneal transplantation. (schmidtandclark.com)
  • That ingredient in concentrations routinely used by AMO and Allergan has been shown to be ineffective against Acanthamoeba in many published studies," says Moore, who added that if AMO wants to take a leadership position in the contact lens solution industry, "they should develop a disinfectant that works, and stop blaming consumers for infections which could be prevented with effective products. (schmidtandclark.com)
  • In the study In Vitro Interactions of Fusarium and Acanthamoeba with Drying Residues of Multipurpose Contact Lens Solutions, the "effects of evaporation and drying of multipurpose contact lens solution" was observed on the survival of Fusarium. (wikipedia.org)
  • The Schmidt Firm, PLLC is currently accepting claims in all 50 states for those who used AMO Complete MoisturePlus and have developed Acanthamoeba Keratitis. (schmidtlaw.com)
  • If you or somebody you know has used AMO Complete MoisturePlus and developed Acanthamoeba Keratitis, you should contact our firm immediately for a free case consultation. (schmidtlaw.com)
  • The presence of these genes homologous to the mimivirus in Sputnik suggests that gene transfer between Sputnik and the mimivirus can occur during the infection of Acanthamoeba. (wikipedia.org)
  • Acanthamoeba has been detected in contaminated water supplies, hot tubs and swimming pools. (aao.org)
  • K. Khairnar, G. S. Tamber, F. Ralevski, and D. R. Pillai, "Comparison of molecular diagnostic methods for the detection of Acanthamoeba spp. (hindawi.com)
  • The T4 genotype is the most commonly reported among keratitis isolates and the most common in environmental samples. (degruyter.com)
  • In one of the experiments done by inoculating Acanthamoeba polyphaga with water containing an original strain of APMV, it was discovered that several capsid layers accumulate asymmetrically on one side of the viral particle causing the virus to become ineffective. (wikipedia.org)
  • H&E stain demonstrates a classic example of the double-walled cyst structure of Acanthamoeba . (uiowa.edu)