Construction Materials: Supplies used in building.Seals, Earless: The family Phocidae, suborder PINNIPEDIA, order CARNIVORA, comprising the true seals. They lack external ears and are unable to use their hind flippers to walk. It includes over 18 species including the harp seal, probably the best known seal species in the world.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Fur Seals: A group comprised of several species of eared seals found in two genera, in the family Otariidae. In comparison to SEA LIONS, they have an especially dense wooly undercoat.Dental Implants: Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.Tantalum: Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)Heart: The hollow, muscular organ that maintains the circulation of the blood.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Cardiac Surgical Procedures: Surgery performed on the heart.Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)Andrology: A scientific or medical discipline concerning the study of male reproductive biology, diseases of the male genital organs, and male infertility. Major areas of interest include ENDOCRINOLOGY; SPERMATOGENESIS; semen analysis; FERTILIZATION; CONTRACEPTION; and CRYOPRESERVATION.Absorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.Contraception: Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.Williams Syndrome: A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.Contraception, Postcoital: Means of postcoital intervention to avoid pregnancy, such as the administration of POSTCOITAL CONTRACEPTIVES to prevent FERTILIZATION of an egg or implantation of a fertilized egg (OVUM IMPLANTATION).Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Contraception Behavior: Behavior patterns of those practicing CONTRACEPTION.Yang Deficiency: In the YIN-YANG system of philosophy and medicine, a lack of vital energy (called yangxu in Chinese). It manifests itself in various systemic and organic diseases. (The Pinyin Chinese-English Dictionary, 1979)Yin-Yang: In Chinese philosophy and religion, two principles, one negative, dark, and feminine (yin) and one positive, bright, and masculine (yang), from whose interaction all things are produced and all things are dissolved. As a concept the two polar elements referred originally to the shady and sunny sides of a valley or a hill but it developed into the relationship of any contrasting pair: those specified above (female-male, etc.) as well as cold-hot, wet-dry, weak-strong, etc. It is not a distinct system of thought by itself but permeates Chinese life and thought. A balance of yin and yang is essential to health. A deficiency of either principle can manifest as disease. (Encyclopedia Americana)Contraceptives, Postcoital: Contraceptive substances to be used after COITUS. These agents include high doses of estrogenic drugs; progesterone-receptor blockers; ANTIMETABOLITES; ALKALOIDS, and PROSTAGLANDINS.Plasticizers: Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.Dental Implants: Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Implants, Experimental: Artificial substitutes for body parts and materials inserted into organisms during experimental studies.Breast Implants: Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.Dental Implantation, Endosseous: Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.Orbital Implants: Rounded objects made of coral, teflon, or alloplastic polymer and covered with sclera, and which are implanted in the orbit following enucleation. An artificial eye (EYE, ARTIFICIAL) is usually attached to the anterior of the orbital implant for cosmetic purposes.Dental Implants, Single-Tooth: Devices, usually alloplastic, surgically inserted into or onto the jawbone, which support a single prosthetic tooth and serve either as abutments or as cosmetic replacements for missing teeth.Bone Screws: Specialized devices used in ORTHOPEDIC SURGERY to repair bone fractures.Fracture Fixation, Internal: The use of internal devices (metal plates, nails, rods, etc.) to hold the position of a fracture in proper alignment.Bone Plates: Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)Internal Fixators: Internal devices used in osteosynthesis to hold the position of the fracture in proper alignment. By applying the principles of biomedical engineering, the surgeon uses metal plates, nails, rods, etc., for the correction of skeletal defects.Fracture Healing: The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Fracture Fixation: The use of metallic devices inserted into or through bone to hold a fracture in a set position and alignment while it heals.Femoral Neck Fractures: Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.Bone Wires: Steel wires, often threaded through the skin, soft tissues, and bone, used to fix broken bones. Kirschner wires or apparatus also includes the application of traction to the healing bones through the wires.Dental Implants: Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Asbestos, Serpentine: A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)Telomere Shortening: The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS.) Telomere shortening is involved in the progression of CELL AGING.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Elasticity: Resistance and recovery from distortion of shape.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Mechanical Processes: The behaviors of materials under force.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Telomere: A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Hydrogels: Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)EstersAbsorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.Polyesters: Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.Methacrylates: Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.Polyglycolic Acid: A biocompatible polymer used as a surgical suture material.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Biodegradable Plastics: Organic polymeric materials which can be broken down by naturally occurring processes. This includes plastics created from bio-based or petrochemical-based materials.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Tooth Socket: A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.Piezosurgery: The use of HIGH-ENERGY SHOCK WAVES, in the frequency range of 20-30 kHz, to cut through mineralized tissue.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Tooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Diamond: Diamond. A crystalline form of carbon that occurs as hard, colorless or tinted isomeric crystals. It is used as a precious stone, for cutting glass, and as bearings for delicate mechanisms. (From Grant & Hackh's Chemical Dictionary, 5th ed)Hydroxyapatites: A group of compounds with the general formula M10(PO4)6(OH)2, where M is barium, strontium, or calcium. The compounds are the principal mineral in phosphorite deposits, biological tissue, human bones, and teeth. They are also used as an anticaking agent and polymer catalysts. (Grant & Hackh's Chemical Dictionary, 5th ed)Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Absorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Equipment Design: Methods of creating machines and devices.Mammography: Radiographic examination of the breast.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.Scent Glands: Exocrine glands in animals which secrete scents which either repel or attract other animals, e.g. perianal glands of skunks, anal glands of weasels, musk glands of foxes, ventral glands of wood rats, and dorsal glands of peccaries.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Echogenic Bowel: A PRENATAL ULTRASONOGRAPHY finding of excessively dense fetal bowel due to MECONIUM buildup.Septal Occluder Device: A CATHETER-delivered implant used for closing abnormal holes in the cardiovascular system, especially HEART SEPTAL DEFECTS; or passageways intentionally made during cardiovascular surgical procedures.Surgical Stapling: A technique of closing incisions and wounds, or of joining and connecting tissues, in which staples are used as sutures.Pneumothorax: An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.Embolism, Air: Blocking of a blood vessel by air bubbles that enter the circulatory system, usually after TRAUMA; surgical procedures, or changes in atmospheric pressure.Respiratory Tract Fistula: An abnormal passage communicating between any component of the respiratory tract or between any part of the respiratory system and surrounding organs.Air: The mixture of gases present in the earth's atmosphere consisting of oxygen, nitrogen, carbon dioxide, and small amounts of other gases.Barotrauma: Injury following pressure changes; includes injury to the eustachian tube, ear drum, lung and stomach.Tissue Adhesives: Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.Pneumonectomy: The excision of lung tissue including partial or total lung lobectomy.Viscoelastic Substances: Substances that display the physical properties of ELASTICITY and VISCOSITY. The dual-nature of these substances causes them to resist applied forces in a time-dependent manner.Reinforcement (Psychology): The strengthening of a conditioned response.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Absorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.Starch: Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.Hemostatics: Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.Polysaccharides, Bacterial: Polysaccharides found in bacteria and in capsules thereof.PolysaccharidesHemostasis: The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Triplets: Three individuals derived from three FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.Hemostatic Techniques: Techniques for controlling bleeding.Drug-Eluting Stents: Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.Stainless Steel: Stainless steel. A steel containing Ni, Cr, or both. It does not tarnish on exposure and is used in corrosive environments. (Grant & Hack's Chemical Dictionary, 5th ed)Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Conducted Energy Weapon Injuries: The injuries caused by conducted energy weapons such as stun guns, shock batons, and cattle prods.Syringes: Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)Injections, Jet: The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Equipment Design: Methods of creating machines and devices.Disposable Equipment: Apparatus, devices, or supplies intended for one-time or temporary use.Needles: Sharp instruments used for puncturing or suturing.Thermoluminescent Dosimetry: The use of a device composed of thermoluminescent material for measuring exposure to IONIZING RADIATION. The thermoluminescent material emits light when heated. The amount of light emitted is proportional to the amount of ionizing radiation to which the material has been exposed.Sterilization: The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.Injections: Introduction of substances into the body using a needle and syringe.

A new strategy for the surgical treatment of aortic coarctation associated with ventricular septal defect in infants using an absorbable pulmonary artery band. (1/490)

OBJECTIVES: We propose a new strategy using coarctation repair together with a polidioxanone absorbable pulmonary artery banding to limit operative risk and to spare infants with aortic coarctation subsequent operations. BACKGROUND: The alternative for the surgical management of aortic coarctation associated with ventricular septal defect (VSD) is single-stage repair versus coarctation repair with or without banding of the pulmonary artery. METHODS: Eleven infants (mean weight 2,560 +/- 1,750 g, range 1,320 to 3,800 g) underwent a coarctation repair with a polydioxanone banding. Seven had a trabecular and four a perimembranous VSD. The mean size of the VSD was 5 +/- 0.7 mm (range 4 to 7 mm). The systolic pulmonary pressure was >80% of the aortic pressure in all. The pulmonary band was tightened until the systolic pulmonary pressure fell below 50% of the aortic pressure. RESULTS: There were no hospital deaths. The reabsorption of the banding was complete after 5.7 months in all patients (3 to 6.5 months). The VSD closed completely in four infants and partially in six, in whom the pulmonary artery pressure was normal without evidence for significant left-to-right shunt. One patient with a large trabecular VSD underwent surgical closure of his defect after four months. Finally, a subsequent open-heart surgery could be avoided in 91% (10/11) of patients. CONCLUSIONS: Provided the VSD belongs to types prone to close spontaneously, this policy may reduce the number of surgical procedures per infant as well as in-hospital mortality and morbidity rates. It should be proposed as an alternative to more complex procedures.  (+info)

Rotational acetabular osteotomy using biodegradable internal fixation. (2/490)

We used biodegradable poly-L-lactide screws in rotational acetabular osteotomy in 41 hips of 41 patients, and studied the complications after an average follow-up of 4.9 years (range 1.0-7.7 years). There were 39 females and 2 males, their average age at the time of the operation was 32 years (range 12-55 years). A small subcutaneous abscess appeared around the non-absorbable sutures in 2 patients after surgery. There was 1 case of thrombophlebitis and 1 of local dermatitis. The small subcutaneous abscess resolved after the removal of the suture material in the 2 cases, and the thrombophlebitis resolved with aspirin. The local dermatitis persisted but was cured by local steroid therapy over 5.8 years. The incidence of local dermatitis after the use of biodegradable implants should be further investigated.  (+info)

Inhibition of neointima formation after experimental coronary artery stenting: a new biodegradable stent coating releasing hirudin and the prostacyclin analogue iloprost. (3/490)

BACKGROUND: To minimize acute stent thrombosis and development of restenosis, stents coated with biodegradable and nonbiodegradable polymers have been proposed to serve as sustained-release drug carriers. METHODS AND RESULTS: In both a sheep and a pig model, we examined the vascular response to standard and high-pressure implantation of coronary Palmaz-Schatz stents coated with a 10-microm layer of polylactic acid (MW 30 kDa) releasing recombinant polyethylene glycol (r-PEG)-hirudin and the prostacyclin analogue iloprost, both drugs with antithrombotic and potentially antiproliferative effects. Study observation time was 28 days. Between the corresponding stent groups, no differences were observed with regard to preplacement and postplacement implantation parameters. The morphometric analysis demonstrated that the coating was associated with a greater lumen diameter through a reduction in the mean restenosis area by 22.9% (P<0.02) in the standard-pressure model (sheep) and by 24.8% (P<0.02) in the overstretch pig model compared with uncoated control stents without inducing a local inflammatory response. CONCLUSIONS: The results from this study demonstrate beneficial effects of a polymeric stent coating with polylactic acid releasing r-PEG-hirudin and iloprost on the development of restenosis after coronary stent placement at 4 weeks, independent of the extent of vascular injury. Future studies are proposed to investigate the integration of other substances to further enhance the potential of the stent coating on reducing neointimal formation.  (+info)

In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity. (4/490)

An alternative technology for the local and sustained delivery of cytokines to tumors for cancer immunotherapy was evaluated and shown here to induce tumor regression, suppression of metastasis, and development of systemic antitumor immunity. Treatment of tumor-bearing BALB/c mice with a single intratumoral injection of biodegradable polylactic acid microspheres loaded with recombinant interleukin-12 (IL-12) promoted complete regression of the primary tumor and prevented the metastatic spread to the lung. Mice that experienced tumor regression after being treated rejected a subsequent challenge with live tumor cells, which indicated the development of systemic antitumor immunity. In situ tumor vaccination, ie., injection of IL-12 microspheres into existing tumors, was superior to vaccination of mice with mixtures of tumor cells (live or irradiated) and IL-12 microspheres in inducing systemic antitumor immunity. The sustained release of IL-12 from the microspheres was superior to bolus injection of free IL-12, and intratumoral delivery of microspheres was more effective than other routes of administration. These studies establish the utility of biodegradable polymer microspheres as a clinically feasible alternative to systemic cytokine therapy and cytokine gene-modified cell vaccines for the treatment of neoplastic disease.  (+info)

Soluble biodegradable polymer-based cytokine gene delivery for cancer treatment. (5/490)

Transgene expression and tumor regression after direct injection of plasmid DNA encoding cytokine genes, such as mIL-12 and mIFN-gamma, remain very low. The objective of this study is to develop nontoxic biodegradable polymer-based cytokine gene delivery systems, which should enhance mIL-12 expression, increasing the likelihood of complete tumor elimination. We synthesized poly[alpha-(4-aminobutyl)-l-glycolic acid] (PAGA), a biodegradable nontoxic polymer, by melting condensation. Plasmids used in this study encoded luciferase (pLuc) and murine interleukin-12 (pmIL-12) genes. PAGA/plasmid complexes were prepared at different (+/-) charge ratios and characterized in terms of particle size, zeta potential, osmolality, surface morphology, and cytotoxicity. Polyplexes prepared by complexing PAGA with pmIL-12 as well as pLuc were used for transfection into cultured CT-26 colon adenocarcinoma cells as well as into CT-26 tumor-bearing BALB/c mice. The in vitro and in vivo transfection efficiency was determined by luciferase assay (for pLuc), enzyme-linked immunosorbent assay (for mIL-12, p70, and p40), and reverse transcriptase-polymerase chain reaction (RT-PCR) (for Luc and mIL-12 p35). PAGA condensed and protected plasmids from nuclease degradation. The mean particle size and zeta potential of the polyplexes prepared in 5% (w/v) glucose at 3:1 (+/-) charge ratio were approximately 100 nm and 20 mV, respectively. The surface characterization of polyplexes as determined by atomic force microscopy showed complete condensation of DNA with an ellipsoidal structure in Z direction. The levels of mIL-12 p40, mIL-12 p70, and mIFN-gamma were significantly higher for PAGA/pmIL-12 complexes compared to that of naked pmIL-12. This is in good agreement with RT-PCR data, which showed significant levels of mIL-12 p35 expression. The PAGA/pmIL-12 complexes did not induce any cytotoxicity in CT-26 cells as evidenced by 3- inverted question mark4, 5-dimethylthiazol-2-yl inverted question mark-2,5-diphenyltetrazolium bromide assay and showed enhanced antitumor activity in vivo compared to naked pmIL-12. PAGA/pmIL-12 complexes are nontoxic and significantly enhance mIL-12 expression at mRNA and protein levels both in vitro and in vivo.  (+info)

Early in vivo experience with tissue-engineered trileaflet heart valves. (6/490)

BACKGROUND: Tissue engineering is a new approach in which techniques are being developed to transplant autologous cells onto biodegradable scaffolds to ultimately form new functional autologous tissue. Workers at our laboratory have focused on tissue engineering of heart valves. The present study was designed to evaluate the implantation of a whole trileaflet tissue-engineered heart valve in the pulmonary position in a lamb model. METHODS AND RESULTS: We constructed a biodegradable and biocompatible trileaflet heart valve scaffold that was fabricated from a porous polyhydroxyalkanoate (pore size 180 to 240 microm; Tepha Inc). Vascular cells were harvested from ovine carotid arteries, expanded in vitro, and seeded onto our heart valve scaffold. With the use of cardiopulmonary bypass, the native pulmonary leaflets were resected, and 2-cm segments of pulmonary artery were replaced by autologous cell-seeded heart valve constructs (n=4). One animal received an acellular valved conduit. No animal received any anticoagulation therapy. Animals were killed at 1, 5, 13, and 17 weeks. Explanted valves were examined histologically with scanning electron microscopy, biochemically, and biomechanically. All animals survived the procedure. The valves showed minimal regurgitation, and valve gradients were <20 mm Hg on echocardiography. The maximum gradient was 10 mm Hg with direct pressures. Macroscopically, the tissue-engineered constructs were covered with tissue, and there was no thrombus formation on any of the specimens. Scanning electron microscopy showed smooth flow surfaces during the follow-up period. Histological examination demonstrated laminated fibrous tissue with predominant glycosaminoglycans as extracellular matrix. 4-Hydroxyproline assays demonstrated an increase in collagen content as a percentage of native pulmonary artery (1 week 45.8%, 17 weeks 116%). DNA assays showed a comparable number of cells in all explanted samples. There was no tissue formation in the acellular control. CONCLUSIONS: Tissue-engineered heart valve scaffolds fabricated from polyhydroxyalkanoates can be used for implantation in the pulmonary position with an appropriate function for 120 days in lambs.  (+info)

Functional living trileaflet heart valves grown in vitro. (7/490)

BACKGROUND: Previous tissue engineering approaches to create heart valves have been limited by the structural immaturity and mechanical properties of the valve constructs. This study used an in vitro pulse duplicator system to provide a biomimetic environment during tissue formation to yield more mature implantable heart valves derived from autologous tissue. METHODS AND RESULTS: Trileaflet heart valves were fabricated from novel bioabsorbable polymers and sequentially seeded with autologous ovine myofibroblasts and endothelial cells. The constructs were grown for 14 days in a pulse duplicator in vitro system under gradually increasing flow and pressure conditions. By use of cardiopulmonary bypass, the native pulmonary leaflets were resected, and the valve constructs were implanted into 6 lambs (weight 19+/-2.8 kg). All animals had uneventful postoperative courses, and the valves were explanted at 1 day and at 4, 6, 8, 16, and 20 weeks. Echocardiography demonstrated mobile functioning leaflets without stenosis, thrombus, or aneurysm up to 20 weeks. Histology (16 and 20 weeks) showed uniform layered cuspal tissue with endothelium. Environmental scanning electron microscopy revealed a confluent smooth valvular surface. Mechanical properties were comparable to those of native tissue at 20 weeks. Complete degradation of the polymers occurred by 8 weeks. Extracellular matrix content (collagen, glycosaminoglycans, and elastin) and DNA content increased to levels of native tissue and higher at 20 weeks. CONCLUSIONS: This study demonstrates in vitro generation of implantable complete living heart valves based on a biomimetic flow culture system. These autologous tissue-engineered valves functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.  (+info)

Scleral plug of biodegradable polymers containing ganciclovir for experimental cytomegalovirus retinitis. (8/490)

PURPOSE: To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS: To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divided into three groups: group A received no treatment, group B was treated once with GCV solution, and group C was treated with a scleral plug containing GCV. Rabbits in group B received an intravitreal injection of GCV solution 1 week after HCMV inoculation. In group C, the scleral plug containing GCV was implanted in the vitreous of the rabbits 1 week after HCMV inoculation. Ophthalmoscopically, vitreoretinal findings in each group were graded from 0+ to 4+ every week for 4 weeks after HCMV injection. RESULTS: Eyes of group A rabbits showed whitish retinal exudates and vitreous opacities 3 days after HCMV inoculation. These materials increased gradually until 3 weeks after HCMV inoculation. Scores for vitreoretinal lesions were significantly lower in eyes of group B rabbits compared with those of group A at 1 week after GCV injection (P < 0.05). However, vitreoretinal inflammation in eyes of group B rabbits increased again thereafter, and no significant difference in inflammation between groups A and B was found 2 weeks after GCV injection. In eyes of group C, scores for vitreoretinal lesions were significantly lower compared with those in both group A and group B at 3 weeks after HCMV inoculation (P < 0.01). CONCLUSIONS: The results demonstrated that sustained release of GCV into the vitreous cavity with biodegradable scleral plugs was effective for the treatment of experimentally induced HCMV retinitis in rabbits.  (+info)

*Extracellular matrix

An entirely absorbable implant is currently under development. Kleinman, H.K.; Luckenbill-Edds, L.; Cannon, F.W.; Sephel, G.C ...

*Oroantral fistula

Different materials, such as synthetic graft materials, xenografts, fibrin glue, synthetic absorbable implant and acrylic ... implant denture, removal of a large cyst or resection of large tumour involving maxilla, development of tumour causing bone ...

*Northern Westchester Hospital

The OSI incorporates Bio-absorbable implants for sports medicine surgery- These are usually constructed of plastic and are ...

*List of MeSH codes (E07)

... absorbable implants MeSH E07.695.050 --- artificial limbs MeSH E07.695.075 --- auditory brain stem implant MeSH E07.695.100 ... implanted MeSH E07.296.319.074 --- auditory brain stem implants MeSH E07.296.319.150 --- cochlear implants MeSH E07.296.319.175 ... dental implants MeSH E07.695.185.185 --- dental implants, single-tooth MeSH E07.695.190 --- dental prosthesis MeSH E07.695. ... auditory brain stem implant MeSH E07.814.458.150 --- cochlear implants MeSH E07.858.082 --- artificial organs MeSH E07.858. ...

*Dupuytren's contracture

"Improved postoperative outcome of segmental fasciectomy in Dupuytren disease by insertion of an absorbable cellulose implant". ... After the excision and a careful hemostasis, the cellulose implant is placed in a single layer in between the remaining parts ... The same procedure is used in the segmental fasciectomy with cellulose implant. ...

*Carsten Maschmeyer

... development and marketing of highly innovative bio-absorbable metal implants, i.e. a second surgery to remove implants would no ...

*Polyorthoester

"Evaluation of absorbable poly(ortho esters) for use in surgical implants", J. Appl. Biomaterials 5 (1): pp. 51-64, doi:10.1002/ ... Such drug implants are particularly suitable for applications on the eye, where no sudden release occurs by diffusion (initial ... Implants made of polyorthoester type IV show surface erosion while being highly biocompatible with degradation times from days ... Polyorthoesters are used as hydrophobic implant materials for drug depots for continuous drug delivery by surface erosion. The ...

*Coronary stent

In development are stents with biocompatible surface coatings which do not elute drugs, and also absorbable stents (metal or ... Guidelines recommend a stress test before implanting stents, but most patients do not receive a stress test. While ... In addition to intervascular stents he also developed the first stent-supported porcine valve that can be implanted ...

*Er:YAG laser

Schwarz F, Olivier W, Herten M, Sager M, Chaker A, Becker J. "Influence of implant bed preparation using an Er:YAG laser on the ... Er:YAG lasers can be used in laser aided cataract surgery but owing to its water absorbable nature Nd:YAG is preferred more. ... Bone surgery applications have been found in oral surgery, dentistry, implant dentistry, and otolaryngology. Er:YAG lasers are ... osseointegration of titanium implants: a histomorphometrical study in dogs". J. Oral Rehabil. 2007;34:273-281. Lewandrowski KU ...

*Bone wax

The portion of traditional bone wax which departs the implant site is most likely carried away through the action of the ... Modern day bone wax is commercially available in substantially non-absorbable formulations similar to Horsley's original ... Hemasorb Resorbable Hemostatic Bone Putty is a sterile, soft, moldable, biocompatible, absorbable material of putty-like ... composition, as well as in absorbable/resorbable formats. Most of these waxes are available as a firm wax in stick form that ...

*Jatene procedure

The aorta is then transplanted onto the pulmonary root, using either absorbable or permanent continuous suture. The aortic ... the circumflex coronary artery will be distorted if the pair are not implanted higher than normal on the neo-aorta, and in some ... and a continuous absorbable suture is then used to anastomose each coronary "button" into the prepared space. In most cases, ... cases they may need to be implanted above the aortic commissure, on the native aorta itself. The circumflex coronary artery may ...

*Drug-eluting stent

In 1986, Puel and Sigwart implanted the first coronary stent in a human patient. Several trials in the 1990s showed the ... The German company, Biotronik, developed a magnesium absorbable stent and published clinical results in 2007. The first company ... Like all invasive medical procedures, implanting stents in the coronary arteries carries risk. For the newer drug-eluting ... who said that more than half of patients with stable coronary artery disease were implanted with stents without even trying ...

*Cordis (medical)

1962 The first synchronous cardiac pacemaker co-developed by Cordis is implanted in a patient. 1970s Cordis introduces the ... 2010 EXOSEAL® an innovative vascular closure device with extravascular bio absorbable plug placement and excellent clinical ...

*Mastopexy

When the breast implant will be emplaced to a subglandular implant pocket, the hypodermic needle penetrates un-resisted into ... and reinforced with strips of absorbable adhesive tape (butterfly stitches) applied to maintain the wound closed. Post- ... into the implant pocket, or is partially deflated. For the subglandular emplacement of breast implants, the technique is ... and malposition of the breast implant in the implant pocket. Therefore, a mastopexy-augmentation procedure features increased ...

*Biotronik

The following year, Biotronik released Orsiro to the market-the world's first hybrid drug-eluting stent with a bio-absorbable ... subscription required) "Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a randomised ... Since its start, more than 19 million BIOTRONIK devices in over 100 countries have been implanted. In 1976, the company moved ... In 2007, Biotronik was given the EuroPCR 2007 Novelty Award for its innovative absorbable metal stents (AMS) by the European ...

*Surgical mesh

Ideally, these implants should be strong enough to survive mechanical loads and actions of whichever body area they become a ... Some types of mesh combine permanent and temporary meshes such as Vipro, which includes both re-absorbable vipryl, made from ... Surgical mesh is implanted to strengthen tissue repair and minimize the rate of recurrence. The surgery can be performed ... Any mesh that is implanted in the pelvic area must be strong enough to withstand these loads. Mesh implantation will naturally ...

*Partial androgen insensitivity syndrome

Motoyama S, Laoag-Fernandez JB, Mochizuki S, Yamabe S, Maruo T (May 2003). "Vaginoplasty with Interceed absorbable adhesion ... Handelsman DJ, Conway AJ, Boylan LM (November 1992). "Suppression of human spermatogenesis by testosterone implants". J. Clin. ... Jackson ND, Rosenblatt PL (December 1994). "Use of Interceed Absorbable Adhesion Barrier for vaginoplasty". Obstet Gynecol. 84 ...

*Management of prostate cancer

Permanent implant brachytherapy is a popular treatment choice for patients with low to intermediate risk features, can be ... A new method to reduce rectal radiation injury in prostate cancer patients involves the use of an absorbable spacer placed ... The risk of exposure to others from men with implanted seeds is generally accepted to be insignificant. However, men are ...

*Osteotomy

It is technically more difficult than an implant and has more swelling and recovery than a simple chin implant. Also, there is ... The layers of tissue in the knee are stitched together, usually with absorbable sutures. A fall or torque to the leg during the ... As opposed to putting an implant on top of the chin bone to bring it forward, an alternative approach is to cut the chin bone ... It can also be used to lengthen the chin (which is more difficult with an implant) or to shorten or narrow a chin. (which is ...

*Pelvic organ prolapse

With surgery (for example native tissue repair, biological graft repair, absorbable and non-absorbable mesh repair, colpopexy, ... "Women Implanted with Transvaginal Mesh Suffer from Painful, Permanent Injuries". Parker Waichman LLP. Retrieved 23 June 2015. ...

*Silk

showed the in vivo degradation of silk via aqueous 3-D scaffolds implanted into Lewis rats. Enzymes are the means used to ... A special manufacturing process removes the outer sericin coating of the silk, which makes it suitable as non-absorbable ... or lower than collagen and PLA when implant rat MSCs with silk fibroin films in vivo. Thus, appropriate degumming and ... there is no need of surgery in order to remove the scaffold implanted. Wang et al. ...

*Diglycolic acid

... cartilage substitutes or as implant materials: L. Bhattacharyya, J. Rohrer, ed. (2012), Appendix 1: DISSOCIATION CONSTANTS (pKa ... "Absorbable polyalkylene diglycolates" ...

*Barrier membrane

"Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants". Clin Oral Implants Res. 17 ... Non-absorbable ePTFE membranes are still used clinically on a regular basis, and long-term studies suggest that bones regrown ... Collagen absorbable barrier membranes do not require surgical removal, inhibit migration of epithelial cells, promote the ... An experimental study in a canine model". Clin Oral Implants Res. 15 (4): 435-42. doi:10.1111/j.1600-0501.2004.01029.x. PMID ...

*Biomaterial

In the United States, 45% of the 250,000 valve replacement procedures performed annually involve a mechanical valve implant. ... Pillai, C. K. S.; Sharma, C. P. (2010). "Review Paper: Absorbable Polymeric Surgical Sutures: Chemistry, Production, Properties ... Pillai CK, Sharma CP (Nov 2010). "Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, ... or may be bioactive with a more interactive functionality such as hydroxy-apatite coated hip implants. Biomaterials are also ...

*Bone morphogenetic protein 2

"Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation". Clin Oral ... The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen ... Clin Oral Implants Res. 17 (6): 666-72. doi:10.1111/j.1600-0501.2006.01214.x. PMID 17092225. Schliephake H, Aref A, Scharnweber ... "Expression of bone matrix proteins during the osseus healing of topical conditioned implants: an experimental study". ...

*Dental extraction

Periodontists are performing more and more extractions, since they often follow up and place a dental implant. The most common ... absorbable agents, biologics, and combination of products (iii) Combination of both A resorbable haemostatic pack, such as ... Tassos Irinakis, Rationale for Socket Preservation after Extraction of a Single-Rooted Tooth when Planning for Future Implant ...
TY - GEN. T1 - Tensile and flexural creep behaviour of self-reinforced polypropylene composites prepared by compression and injection molding. AU - Kmetty, Á. AU - Bakonyi, P.. AU - Vas, M. L.. AU - Bárány, T.. PY - 2012. Y1 - 2012. N2 - In this work the creep behavior of self-reinforced polymer composites (SRPC) were investigated. As matrix material olefin based thermoplastic elastomeric (o-TPE), as reinforcement highly oriented polypropylenes were used. The tested self-reinforced composites were prepared by filament winding with subsequent compression molding and injection molding (from new pre-impregnated pre-product material) technique. On the SRPC creep tests were carried out. The tensile and flexural creep tests were performed by universal tensile machine and dynamic mechanical analyzer (DMA) test. The results revealed that the creep behavior of the self-reinforced materials depended on the matrix material and the reinforcement structure. The highest strain was achieved using woven ...
Endosteal fixation of a ligament graft with a bioabsorbable interference screw installed in a retrograde manner in ACL reconstruction. The bioabsorbable interference screw is insert-molded with a length of suture extending from the distal tip of the screw for pulling the interference screw into the joint and into position for retrograde insertion at the top of the tibial tunnel. The interference screw has a cannulation extending partially through the screw from the leading tip. The cannulation is shaped to receive a correspondingly shaped driver. The driver is inserted into the tibial tunnel to engage the screw. By turning the driver, the interference screw is turned into the tibial tunnel in a retrograde manner. Accordingly, interference fixation of the graft near the tibial plateau is provided, thereby eliminating graft abrasion at the tibial plateau tunnel opening.
This is the first case in the literature describing the V-stenting technique using ABSORB (Abbott Vascular, Santa Clara, California) bioresorbable everolimus-eluting scaffolds (BVS) for the treatment of a left main coronary artery (LMCA) true bifurcation lesion. A 66-year-old woman presented with symptoms of stable angina. A diagnostic angiogram revealed a significant mid-left anterior descending artery (LAD) lesion. After successful implantation of 2 BVS in the mid-LAD, a control angiogram showed haziness extending from distal LMCA into LAD ostium (Medina 0.1.1), likely representing plaque disruption (Fig. 1-I). Due to the fact that the lesions extended in both the LAD and left circumflex artery, we decided to perform V-stenting. A 3.5 × 12-mm BVS (LMCA-LAD) and a 3.5 × 18-mm BVS (LMCA-left circumflex artery) were simultaneously deployed followed by final kissing-balloon inflation. An excellent final angiographic result was achieved (Fig. 1-III). Post-procedural intravascular ultrasound and ...
Widening of the single tibial tunnel following ACL surgery with quadrupled hamstrings autograft may contribute to failure of the graft and/or present technical challenges secondary to bone loss in a revision setting (Getelman, 1999). As such, efforts should be made to minimize the incidence and magnitude of tibial tunnel widening without sacrificing the biomechanical properties of the graft construct. The purpose of this investigation is to examine the tibial tunnel widening relationship between bioabsorbable interference screws composed of poly-L-lactic acid (PLLA) alone and composite bioabsorbable interference screws composed of poly-L-lactic acid embedded with beta tricalcium phosphate (PLLA+TCP) utilized as tibial fixation devices.. Specifically the study has the following objectives: 1) To quantify the extent of tibial tunnel enlargement at 3-, 6- and 12-months post ACL reconstruction with autogenous quadrupled hamstring graft; 2) To determine if the incorporation of beta tricalcium ...
Plaster of Paris is employed to form implants as well as a bioresorbable scaffold for implants and bone repair in animals. In bone repair, the plaster is mixed with a non-bioresorbable calcium source,
Mountain View, Calif.-based Amaranth Medical announced a $20 million Series B funding round in support of development of the companys flagship Fortitude bioresorbable scaffold, a device-based treatment for coronary artery disease.. Amaranth plans to use the funds to further progress in clinical trials in hopes of winning CE Mark approval in the European Union, according to a company statement. ...
Ultrasonically Assisted Anchoring of Biodegradable Implants for Chevron Osteotomies - Clinical Evaluation of a Novel Fixation Method
The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreacto
Self-reinforced poly(ethylene terephthalate) composite laminates were manufactured from fabric using a hot press. Fabric was either allowed to shrink or exposed to stretching during different phases of the manufacturing process. Composite macrostructure, crimp, was investigated and results showed that shrinkage affects fibre crimp more than stretching does. Mechanical tests showed that shrinkage do not significantly affect mechanical properties while stretching fabric by 10% during heating results in 50% increase in tensile stiffness. The lack of correlation between crimp and mechanical properties indicates that mechanical properties for self-reinforced poly(ethylene terephthalate) composites are dominated by their microstructure, molecular orientation, which may be affected by the manufacturing process.. ...
BACKGROUND: The Absorb bioresorbable vascular scaffold (BVS) completely resorbs within 3 years after coronary artery implantation. The safety and effectiveness of BVS through this critical 3-year period have not been characterized.. METHODS: We performed an individual-patient-data pooled meta-analysis of the 4 randomized ABSORB trials in which 3389 patients with coronary artery disease were randomly assigned to everolimus-eluting Absorb BVS (n=2164) or cobalt-chromium everolimus-eluting stents (n=1225). The primary efficacy outcome measure was target lesion failure (cardiac mortality, target vessel myocardial infarction, or ischemia-driven target lesion revascularization), and the primary safety outcome measure was device thrombosis.. RESULTS: BVS compared with cobalt-chromium everolimus-eluting stents resulted in higher 3-year rates of target lesion failure (11.7% versus 8.1%; risk ratio [RR], 1.38; 95% confidence interval [CI], 1.10-1.73; P=0.006), driven by greater target vessel myocardial ...
The absence of clinical restenosis in the first major trial of metallic drug-eluting stents (DES) (1) elicited unbridled enthusiasm among interventional cardiologists. However, it did not take long to realize that, although DES were a marked improvement over bare-metal stents (2), they were not perfect. Specifically, McFadden and et al. (3) reported a new complication in 4 patients, late stent thrombosis occurring after discontinuation of dual antiplatelet therapy (DAPT) (3). Since then, we have learned that target lesion-related failures after 1 year (including restenosis as well as thrombosis) occur at a frequency of 2% to 3% per year for all permanent metallic stents, a rate that may continue for 20 years or longer (4,5). The mechanisms contributing to these stent-related failures are multifactorial and include incomplete endothelialization, persistent inflammation, vessel straightening and compliance mismatch, strut fracture, neoatherosclerosis, and others. Bioresorbable vascular scaffolds ...
This is the first prospective study to evaluate the economic outcomes associated with the use of a bioresorbable scaffold versus a conventional DES among patients undergoing PCI. In this randomized trial involving 2,008 patients with stable and unstable coronary artery disease, we found that the use of the Absorb scaffold was associated with slightly higher procedural costs and index hospitalization costs when compared with the Xience stent. Although the total 1-year costs were also numerically higher in the Absorb group, the cost difference was small (approximately $350/patient) and was not significant. Taken together with clinical outcomes demonstrating statistical noninferiority of the Absorb scaffold to the Xience DES, these findings demonstrate roughly comparable clinical and economic outcomes with these 2 devices within 1 year (assuming a $100 per device price difference). However, these results remain uncertain at present, because the ABSORB III trial was underpowered to exclude small ...
Bioresorbable drug-eluting scaffolding appears to be safe and effective in patients with iliac and femoral artery lesions, based on six-month results in the first-in-man ESPRIT trial presented Jan. 22 at the International Symposium on Endovascular Therapy in Miami Beach, Fla.
The DESappear study is an important milestone in the pursuit of bringing innovative therapies with state-of-the-art bioresorbable technologies to treat a vulnerable population of patients with peripheral arterial disease," said Bosiers. "I am excited to be working with Akesys Medical with the goal to bring this vital product to the clinic.". DESappear investigator Andrew Holden, director of Interventional Services at Auckland City Hospital and associate professor of Radiology at Auckland University School of Medicine, implanted the first Prava in a 66-year-old patient with 45mm of disease in the mid-superficial femoral artery and 80% blockage.. "The diabetic patient with short distance leg claudication demonstrated 0% residual stenosis following the procedure with the Prava scaffold and has recovered well," said Holden. "The Prava scaffolds easy deliverability for treatment and its excellent structural support to the vessel without leaving behind a permanent metallic implant has the potential ...
Novel methods for assessing the electrochemical and micromechanical performance of modular tapers were evaluated, and self-reinforced composite materials were developed for their potential to prevent the onset of mechanically assisted corrosion in modular taper devices. A study of the seating and taper locking mechanics of modular taper samples was conducted, and the effect on taper engagement strength of seating load, loading rate, taper moisture, and taper design/material combination was studied. The load-displacement behavior was captured during seating, and the subsequent pull off load was correlated to seating displacement, seating energy, and seating load. The primary factor affecting taper engagement strength was seating load, and loading rate and design/material factors did not have a significant impact on the quality of the taper engagement. Next, the effect of variation of 7 different design, material, and surgical factors on the fretting corrosion and micromechanical behavior during
Vascular response after coronary angioplasty varies according to the technique. Acute response after balloon angioplasty is characterized by luminal gain in most cases, although dissection can occur during the procedure, putting coronary artery patency at risk. Arterial "elastic recoil" sometimes follows this acute luminal gain, resulting in some degree of restenosis.. Bare-metal stents represented a great advance because they overcame these 2 main limitations of balloon angioplasty. However, vascular damage created by bare-metal stent implantation can result in intense tissue proliferation around the struts, leading to another form of restenosis: proliferative rather than mechanical recoil. Drug-eluting stents (DES) were developed to overcome this limitation by incorporating antiproliferative drugs. First-generation DES changed the post-stenting healing process; however, the lack of coverage of a substantial amount of DES struts was shown to contribute substantially to stent thrombosis ...
Researchers for the DESolve study recommended testing the latest iteration of the device in a larger group of patients, based on results of a first-in-man-study published in the December issue of the Journal of the American College of Cardiology: Cardiovascular Interventions.
The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substant
Biodegradable polymer networks are provided which are useful in a variety of dental and orthopedic applications. The biodegradable polymer networks can be formed in one embodiment by polymerizing anhydride prepolymers including crosslinkable groups, such as unsaturated moieties. The anhydride prepolymers can be crosslinked, for example in a photopolymerization reaction by irradiation of the prepolymer with light in the presence of a free radical initiator. Suitable anhydride prepolymers include dianhydrides of a dicarboxylic acid and a carboxylic acid molecule comprising a crosslinkable group. For example, methacrylic acid dianhydrides of monomers or oligomers of a diacid such as sebacic acid or 1,3-bis(p-carboxyphenoxy)-hexane can be used. The anhydride prepolymers can be applied in vivo to a site where an orthopedic implant is needed, and then may be crosslinked, for example, by irradiation with U.V. light, to form a biodegradable implant such as a rods, pin or plate. The implants advantageously
May 15, 2017 - Faculty from the Cardiovascular Research Foundation (CRF) will be presenting research and lectures at EuroPCR 2017 taking place May 16-19 at the Palais des Congrès in Paris, France. They will be sharing the latest research and information on bioresorbable vascular scaffolds, imaging technologies, transcatheter aortic valve replacement, heart failure and other topics.. CRF faculty are world-renowned experts in the field of interventional cardiovascular medicine. Research presentations include the following: Tuesday, May 16, 2017. Euro17A-OP0530 - Multicenter evaluation of a novel 120µm DeSolve CX BRS: first report of six-month clinical and imaging endpoints. Session: Evolving BRS technology (comprising selected EuroPCR 2017 late-breaking trial submissions). 12:26 PM - 12:39 PM; Level 3, Room 351. Alexandre Abizaid, MD, PhD. Euro17LBT-OP0080 - The FANTOM II study: first report for the 12-month clinical outcomes of the Fantom sirolimus eluting bioresorbable scaffold. Session: ...
North America emerged as the largest regional player in the global bioresorbable polymers market due to the high level of technological sophistication in the healthcare sector in the U.S. and Canada. The U.S. is the major R&D hub for the medical industry, further driving the North America bioresorbable polymers market. The similarly advanced healthcare scenario in Europe, particularly Western Europe, has driven the European market for bioresorbable polymers market. However, Asia Pacific is expected to become a major regional market for bioresorbable polymers in the coming years. ...
Read "Supramolecular structure of polylactides: Influence of the crystallization parameters on the structure of film samples, Russian Journal of Applied Chemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Achievement of final in-scaffold/stent residual stenosis of less than 30% by QCA (by visual estimation if QCA unavailable) with successful delivery and deployment of at least one assigned scaffold/stent at the intended target lesion and successful withdrawal of the delivery system for the target lesion without the occurrence of cardiac death, target vessel MI or repeat TLR during the hospital stay (maximum of 7 days). In dual target lesion setting, both lesions must meet clinical procedure success criteria to have a patient level procedure success.. Acute success (device success and procedure success) was determined based on the device randomized while the Per-Treatment-Evaluable Population (PTE) analysis must be based on the device actually received. Hence, device success and procedure success were provided for the ITT population only. ...
The objective was to investigate the acute mechanical effects of post-dilatation on bioresorbable scaffolds (BRS) as determined by optical coherence tomography (OCT). Post-dilatation with high-pressur
Wykrzykowska et al report a randomized clinical trial of metallic stent v bioresorbable vascular scaffold in routine percutaneous coronary intervention. They found significantly higher risk of device thrombosis with BVS. The editorial is available here. Summary BACKGROUND Bioresorbable vascular scaffolds were developed to overcome the shortcomings of drugeluting stents in percutaneous coronary intervention (PCI). We…
While coronary stents have been used to treat CAD since the 1990s, a new stent technology - the SYNERGY Bioabsorbable Polymer Drug-Eluting Stent System - was approved by the U.S. Food and Drug Administration in October 2015, and is the first and only bioabsorbable polymer stent available in the U.S. Unlike traditional drug coated stents that feature permanent polymer coatings known to cause inflammation within the vessels, the SYNERGY stents coating dissolves and disappears after the stents drug has been released. This action enables quick healing of the blood vessel, leaving only the metal part of the stent in the body; ensuring that the blood vessel remains propped open and can deliver blood to the heart for life.. ...
In medicine, a stent is any device which is inserted into a blood vessel or other internal duct in order to expand the vessel to prevent or alleviate a blockage. Traditionally, such devices are fabricated from metal mesh and remain in the body permanently or until removed through further surgical intervention. A bioresorbable stent, (also called biodegradable, or naturally-dissolving) serves the same purpose, but is manufactured from a material that may dissolve or be absorbed in the body. The use of metal drug-eluting stents presents some potential drawbacks. These include a predisposition to late stent thrombosis, prevention of late vessel adaptive or expansive remodeling, hindrance of surgical revascularization, and impairment of imaging with multislice CT. To overcome some of these potential drawbacks, several companies are pursuing the development of bioresorbable or bioabsorbable stents. Like metal stents, placement of a bioresorbable stent will restore blood flow and support the vessel ...
Drug-eluting stents (DES) have reached a high safety and efficacy profile, becoming the best option for percutaneous coronary interventions (PCI) based revascularization. However, despite their optimal performance, a few concerns remain regarding their use, mainly due to permanent caging of the vessels and its consequences, first of all late stent thrombosis (ST). Bioresorbable scaffolds (BRS) aim to overcome these issues. The results achieved in randomized controlled trials (RCT) by the first generation of poly-L-lactic acid (PLLA) based scaffolds were promising at 1 year, but the first long term reports (albeit flawed by non-optimal implantation technique) have been disappointing, showing, for instance, an increased risk of ST and target vessel myocardial infarction (TV-MI ...
Summary. GlobalDatas Medical Devices sector report, Bioabsorbable Stents - Medical Devices Pipeline Assessment, 2015″ provides an overview of Bioabsorbable Stents currently in pipeline stage.. The report provides comprehensive information on the pipeline products with comparative analysis of the products at various stages of development. The report reviews major players involved in the pipeline product development. It also provides information about clinical trials in progress, which includes trial phase, trial status, trial start and end dates, and, the number of trials for the key Bioabsorbable Stents pipeline products.. Browse Full Report With TOC at ...
Summary. GlobalDatas Medical Devices sector report, Bioabsorbable Stents - Medical Devices Pipeline Assessment, 2015″ provides an overview of Bioabsorbable Stents currently in pipeline stage.. The report provides comprehensive information on the pipeline products with comparative analysis of the products at various stages of development. The report reviews major players involved in the pipeline product development. It also provides information about clinical trials in progress, which includes trial phase, trial status, trial start and end dates, and, the number of trials for the key Bioabsorbable Stents pipeline products.. Browse Full Report With TOC at ...
Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent
Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm 3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic
480 Biomedical focuses on the development of a bioresorbable scaffold for treating occlusive disease in the superficial femoral artery (SFA). Its lead product, SFA scaffold, is a proprietary scaffold and delivery system for use in treating peripheral arterial disease in the SFA. The company was founded in 2011 and is based in Watertown, Massachusetts. ...
We also look at two other, as-yet unapproved devices. One is less intrusive than the OsteoFab skull patch, and would be worn as an exoskeleton on the outside of the body to immobilize and support a broken limb. The other is more intrusive, and would create a prosthesis for a missing nose or ear from a bioresorbable scaffold and a persons own stem cells. Two experts weigh in on what the FDA may require before approving these devices.. ...
Results In total 100 patients underwent PCI with a SYNERGY during the one-year study period. The mean age was 72.3 years (10.0; range 41-92 years), 37% of the cohort was defined as elderly (age ,75 years) and 8% defined as very elderly (age ,85 years). Mean EuroSCORE was 11.37 (11.13, range 0.88-70.23). The indication for SYNERGY stent use was as follows; frail or elderly (16%), concurrent anticoagulation (28%) need for a non-cardiac procedure (10%), increased bleeding risk (31%), or other (15%). NSTEMI/STEMI was the presenting complaint in 32% of patients. The coronary disease was complex. Left main stem was involved in (13%), multi-vessel disease (36%), bifurcation disease requiring side-branch stenting (9%), and 37% required CTO intervention. Mean Syntax score was 22.7 (12.1, range 6-53). The mean stent length/ patient was 75.3 mm (41.5) with 1.44 (0.64) lesions treated and 2.67 (1.33) stents implanted per patient. DAPT discontinuation by 3 months has occurred in 52% to date (planned in ...
There is an ongoing clinical need for tissue-engineered small-diameter (,6 mm) vascular grafts since clinical applications are restricted by the limited availability of autologous living grafts or the lack of suitability of synthetic grafts. The present study uses our self-assembly approach to produce a fibroblast-derived decellularized vascular scaffold that can then be available off-the-shelf. Briefly, scaffolds were produced using human dermal fibroblasts sheets rolled around a mandrel, maintained in culture to allow for the formation of cohesive and three-dimensional tubular constructs, and then decellularized by immersion in deionized water. Constructs were then endothelialized and perfused for 1 week in an appropriate bioreactor. Mechanical testing results showed that the decellularization process did not influence the resistance of the tissue and an increase in ultimate tensile strength was observed following the perfusion of the construct in the bioreactor. These fibroblast-derived ...
Zhao, Y.T., He, M., Zhao, L., Wang, S., Li, Y.P., Gan, L., Li, M., Xu, L., Chang, P.R., Anderson, D.P., and Chen, Y. (2016). Epichlorohydrin-crosslinked hydroxyethyl cellulose/soy protein isolate composite films as biocompatible and biodegradable implants for tissue engineering., ACS Applied Materials & Interfaces, 8(4), pp. 2781-2795. doi : 10.1021/acsami. ...
This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
Future Market Insights on Global Bioabsorbable Stents Market Future Market Insights recently published a fully researched publication on "Global Bioabsorbable Stents Market: Industry analysis (2012-2016) and Opportunity Analysis (2017-2022)", which...
The FDA does not approve of any food item or drug until it has verified everything regarding its safety for human consumption. Today, it has given the go-ahead signal for the first-ever absorbable stent. It will come in handy in the treatment of coronary artery disease.. Get the Free Tracker App to find a Luvabella in Stock. Termed the Absorb GT1 Bioresorbable Vascular Scaffold System (BVS), it gives off the drug everolimus which retards the formation of scar tissue. Also the stent is absorbed by the body slowly and steadily over the course of three years. This approval by the FDA is of great significance since the absorbable stent is a novel treatment method for people who are ideal candidates for angioplasty.. The fact that the stent is absorbable means that those individuals who fear the interventionist scheme of having a foreign metal stent in their bodies would prefer this new method of prophylaxis.. Coronary heart disease (CHD) claims as many as 370,000 lives every year in the United ...
BARCELONA, Spain, May 20, 2009 - Six months outcome of Sahajanand Medical Technologies Supralimus-Sirolimus Eluting stent with Bioabsorbable Polymer was presented at EuroPCR 2009. This analysis was performed as a part of the prospective of E-Series Multicenter Registry. The dataset demonstrates excellent results in high risk patients with complex coronary lesions, including high procedural success rate (> 97%), and sustained safety.. Presented by Dr. Ricardo A. Costa, of Cardiovascular Research Center, Brazil, Preliminary clinical results at 6 months (60%) from Multicenter E-Series Registry demonstrate clinical effectiveness of Supralimus in preventing revascularization, with only 2% TVR (Target Vessel Revascularization) rate. There were no thrombosis events and no TVR/TLR in the Supralimus treated patients in-Hospital. The stent thrombosis rate (definite/probable, ARC) up to 6 months was less than 1%.. Out-of Hospital adverse events (N=718) included only 2% Cardiac Death, 0.5% MI (Myocardial ...
Dealing with bioresorbable vascular scaffolds (BVS) implantation in long lesions requiring device overlapping in this particular moment might seem a little provocative for several reasons. First, most studies testing BVS have focused on their safety and efficacy profile in simple patients with simple lesions. Second, ABSORB II did not meet its primary endpoint, while ABSORB III showed a higher rate of target vessel-myocardial infarction (TV-MI) at 2 years. Third, data on porcine model showed that overlapping zone has delayed but greater neointimal proliferation with consequent higher risk for scaffold thrombosis in the short-term and of in-scaffold restenosis in the long-term ...
PURPOSE: The use of bioabsorbable self-reinforced poly(L/DL)lactide 70/30 (SR-PLDLA) miniplates and screws could offer many benefits compared with conventional metallic devices for fixation of access osteotomies in oral cancer surgery. The material neither interferes with imaging nor with postoperative radiotherapy. The plates and screws do not need to be removed ...
Resorbable materials and their preparation based on gelling a solution of a single polylactide enantiomer. The gel may be dried to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials. Physical and mechanical properties of the material may be varied by varying the molecular weight of the gelling polymer, or by blending the gelling solution with other polymers or fillers. The resorbable materials can be used to make biodegradable implantation devices.
12-month data from the RESTORE pilot clinical trial between December 2011 and July 2012 were also presented at TCT. The RESTORE trial was designed to evaluate safety and performance of the first generation ReZolve sirolimus-eluting bioresorbable coronary scaffold. Imaging results of patients treated with ReZolve who remained event free after treatment demonstrated a mean in-stent late loss of 0.29 mm. When imaging results for patients who had undergone retreatment for focal in-stent restenosis the mean in-stent late loss was 0.69 mm ...
The goal of this project is to investigate antibacterial property and biocompatibility of a new class of bioresorbable alloys for musculoskeletal repair and rec...
Ongoing development of bioresorbable stent (BRS) technologies that are bioresorbed after achieving vessel expansion in percutaneous coronary intervention procedures is an important option to optimise outcomes in patients whose needs are not adequately met with current devices, EuroPCR advised in a statement issued at the close of the 2017 annual course.
Page contains details about bioresorbable electronic stent . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
ESSEN, Germany -- An investigational bioabsorbable magnesium coronary stent worked as advertised for several months but led to a higher revascularization rate at one year.
PARIS -- The bioabsorbable DESolve novolimus-eluting coronary scaffold was effective and safe in a pivotal trial that formed the basis for its European approval last week, a researcher reported here.
Research Report on Global Bioabsorbable Stents Sales Market Report to 2021. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
A typical discussion at BioStar.. Discussion begins with a query, generates various answers, and yields additional comments that can lead to further information. Community voting on questions and answers contributes to reputation points and badges earned by users, along with activities such as editing and other types of participation. Question tags and automatically generated "related" questions can lead to further exploration of a topic. BioStar allows for additional answers to be appended at any time. Some questions acquire community "wiki" status if the issue is better served by a group discussion than by a discrete answer.. ...
A resorbable marrow cavity closure comprises a plug formed of randomly packed, crimped pieces of thread of a resorbable polymer material.
A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C2-16 α-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.
This book gives a thorough overview of the manufacture and uses of low environmental impact polymers. This book will provide information for the experienced user of polymers wanting to use biodegradable materials and also be useful to designers, specifiers, end users and waste managers.
This book gives a thorough overview of the manufacture and uses of low environmental impact polymers. This book will provide information for the experienced user of polymers wanting to use biodegradable materials and also be useful to designers, specifiers, end users and waste managers.
The most ingenious designs revel in the struggle, delight, and mess of production. To make the nappy cloth of her felt purse (above), Sunny Chong drove around town for several days while sitting on a plastic bag filled with a mix of wool, water, and soap. A little friction and body heat and-presto!-felt. Meanwhile, Karine Sarkissian turned rough thread into a sculptural swing (below) and a petite, slouchy chair (top). The seats came out of long period of experimentation with jute, a cheap fiber thats found in abundance in nature. When it proved too unwieldy to knit with, she simply created a giant spool of jute thread, using a trash can and a lampshade to get the shape right, and molded it into a structure that can support a person. Like the rest of the student projects, her chairs are made from biodegradable materials that require few chemical or mechanical processes. "Though I used some organic glue," she says somewhat apologetically.. ...
is a collection of processes by which microorganisms break down biodegradable material in the absence of oxygen. The process is used for industrial or domestic purposes to manage waste and/or to produce fuels. ...
A helical stent having bioresorbable connecting members connecting sections of the stent. The connecting members provide various spring rates or spring constants to the stent, and permit a change in the flexibility of the stent subsequent to implantation while maintaining the unitary design of the stent. A method of making the helical stent includes forming a tube with a section made of a bioresorbable material prior to forming the stent.
PCL individually possess an excellent and proven safety-biocompatibility profile. This is proven through decades of extensive documented evidence from scientific literature and test results. It has been used successfully in numerous CE-marked and FDA-approved commercial bioresorbable medical devices for several decades world-wide ...
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2-FLUOROPROPIOPHENONE 21120-36-5 route of synthesis, 2-FLUOROPROPIOPHENONE chemical synthesis methods, 2-FLUOROPROPIOPHENONE synthetic routes ect.
Define Magnesium alloy. Magnesium alloy synonyms, Magnesium alloy pronunciation, Magnesium alloy translation, English dictionary definition of Magnesium alloy. n. Symbol Mg A light, silvery-white, moderately hard metallic element that in ribbon or powder form burns with a brilliant white flame. Obtained chiefly...
29. Muramatsu T, Onuma Y, García-García HM, Farooq V, Bourantas CV, Morel MA, Li X, Veldhof S, Bartorelli A, Whitbourn R,Abizaid A, Serruys PW; ABSORB-EXTEND Investigators. Incidence and short-term clinical outcomes of small side branch occlusion after implantation of an everolimus-eluting bioresorbable vascular scaffold: an interim report of 435 patients in the ABSORB-EXTEND single-arm trial in comparison with an everolimus-eluting metallic stent in the SPIRIT first and II trials. JACC Cardiovasc Interv. 2013; 6(3):247-57. (IF:6.552 ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
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... ,The Stryker Bioabsorbable Wedge Interference Screw is made of Poly-L Lactic Acid (PLLA). The patented wedge design makes it perfect for cruciate reconstruction and is indicated for BTB and soft tissue grafts.,medicine,medical supply,medical supplies,medical product
DIN 54900-2 : German Language - TESTING OF THE COMPOSTABILITY OF POLYMERIC MATERIALS - PART 2: EVALUATION OF THE COMPLETE BIODEGRADABILITY OF POLYMERIC MATERIALS IN LABORATORY TESTS
A moisture-absorbing polymeric material is disclosed which consists of a combination of a thermoplastic material with an absorbing agent. The thermoplastic material is chosen such that when the absorbing agent is added to the thermoplastic material in the molten state and subsequently formed into a product, the absorbing agent tends to migrate towards the surface of the moisture-absorbing polymeric material to form a migration zone, wherein the absorbing agent is more highly concentrated in the surface of the polymer material than towards the interior.
Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
The hot deformation characteristics of AZ31 magnesium alloy rod extruded at temperatures of 300 °C, 350 °C and 450 °C have been studied in compression. The extruded material had a fiber texture with parallel to the extrusion axis. When extruded at 450 °C, the texture was less intense and the direction moved away from the extrusion axis. The processing maps for the material extruded at 300 °C and 350 °C are qualitatively similar to the material with near-random texture (cast-homogenized) and exhibited three dynamic recrystallization (DRX) domains. In domains #1 and #2, prismatic slip is the dominant process and DRX is controlled by lattice self-diffusion and grain boundary self-diffusion, respectively. In domain #3, pyramidal slip occurs extensively and DRX is controlled by cross-slip on pyramidal slip systems. The material extruded at 450 °C exhibited two domains similar to #1 and #2 above, which moved to higher temperatures, but domain #3 is absent. The results are interpreted in terms of the
Metal-induced artifacts in computed tomography and magnetic resonance imaging: Comparison of biodegradable magnesium alloy versus titanium and stainless steel ...
Metal-induced artifacts in computed tomography and magnetic resonance imaging: comparison of a biodegradable magnesium alloy versus titanium and stainless steel ...
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TM 1-1500-204-23-6 Table 4-7. Identification of Magnesium Alloys Commercial designation Current DOW1 ASTM2 AMC3 specification Conditions Sheet and Plate FSI AX31A C52S QQ-M-44 O (Fully Annealed) H24 (Strain Hardened Partially Annealed) H26 (Strain Hardened Partially Annealed) AX31B O (Fully Annealed) H24 (Strain Hardened Partially Annealed) Rods, Bars, and Shapes JI AZ61A C57S QQ-M-31 As Extruded FSI AZ31B C52S QQ-M-31 As Extruded M MIA 3S QQ-M-31 As Extruded 01 AZ80A C58S QQ-M-31 As Extruded Tubing FSI AX31 A C52S WW-T-825 JI AZ61A C57S WW-T-825 M MIA 3S WW-T-825 Commercial designation Current DOW ASTM AMC specification Type Temper Castings H A263A 265 QQ-M-56 Sand AC (As Cast) HT (Heat-Treated and Aged) ACS (As Cast and Stabilized) HTS (Heat-Treated and Stabilized) M MIB 403 QQ-M-56 Sand AC C A292A 260 QQ-M-56 Sand AC HT HTA ACS HTS A291 QQ-M-56 Sand AC HT HTA See footnotes at end of table. 4-15 ...
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The Absorb stent is a significant advance in the way that coronary artery disease can be treated," said Philippe L.-LAllier, M.D., director, interventional cardiology, Montreal Heart Institute. "Its novel technology means that once the stent has dissolved, the treated artery can pulse and flex as demands on the heart change with everyday activities. It also means physicians can more easily offer their patients other treatment options if necessary in a patients future." With Health Canadas approval of the Absorb bioresorbable stent, Abbott plans to offer the innovative device to Canadian hospitals nationwide starting this summer. Alberta resident, Cynthia Gibeau, 60, was treated with the Absorb bioresorbable heart stent three years ago through a special access program after she was diagnosed with blockages in her coronary arteries. "When I was told that I could receive a stent that would disappear once it had done its job, I felt so relieved," said Cynthia. "Its been three years since the ...
ACC 2017, 3/30/2017 - Poor Outcomes for Bioresorbable Stents in Small Coronary Arteries WATCH VIDEO: Bioresorbable Stent Comparable to Xience at Two Years, With Concerns Stephen Ellis, M.D., professor of medicine and director of interventional cardiology at Cleveland Clinic, discusses the two year outcomes of the ABSORB III trial of Absorb vs. Xience.…
Abbotts Bioabsorbable Stent Technology Holds Promise asFuture-Genera...ABBOTT PARK Ill. March 24 2007 /PRNewswire-FirstCall/ --Abbott tod... The encouraging results from the first 30 patients of ABSORBsuggest ...The single MACE event reported was a non-Q-wave myocardialinfarction.......,Abbott,Announces,Positive,Six-Month,Results,From,the,Worlds,First,Clinical,Trial,of,a,Fully,Bioabsorbable,Drug-Eluting,Coronary,Stent,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides and polyethers, and to the resulting compositions. The polymers are associated with each other, and are then either dried or are used as fluids. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes can be varied as needed by carefully adjusting the pH of the polymer casting solutions, polysaccharide composition, the polyether composition, or by conditioning the membranes prior to surgical use. Bi- or multi-layered membranes can be made
Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The bodys moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.
Market Segments: Global Surgical Stents market has been segmented On the basis of Types; which consist of cardiac stents, Urinary stents, Urethral and prostatic stent. Cardiac stents majorly covers; Bio-engineered Stent, Drug Eluting Stent (DES), Bioresorbable Vascular Scaffold (BVS), Bare Metal Stent (BMS),Dual Therapy Stent (DTS) On the basis of End Users; which includes hospitals…
Current Applied Polymer Science publishes expert review articles and thematic issues in all applied aspects of polymer science including composites, nano polymeric composites and molecular composites, It includes biodegradable polymers, polysaccharides and other natural polymers, membranes, energy conversion and storage, conducting polymers, biomedical implants, and synthetic polymers. It will cover miscible and compatible polymer blends, amorphous and semi-crystallline polymer blends, rubber toughened and elastomeric blends, self-reinforced blends, interpenetrating networks and all other aspects of polymer science as applied to various fields of pharmaceuticals, industrial manufacture, health, agriculture, new materials and other areas.
The U.S. Food and Drug Administration today approved the first fully absorbable stent to treat coronary artery disease. The Absorb GT1 Bioresorbable Vascular Scaffold System (BVS), which releases the drug everolimus to limit the growth of scar tissue, is gradually absorbed by the body in approximately three years.
Last night news began circulating on Twitter that Abbotts Absorb BVS (Bioresorbable Vascular Scaffold) was being withdrawn from the European market. This information was prompted by several physicians posting on Twitter a March 31 "Urgent Field Safety Notice/Physician Advisory" letter from Abbott addressed to "Valued Abbott Vascular Customer.". A number of news sources, including this one, posted articles and tweets to the effect that the Absorb was being taken off the commercial markets and, as the letter stated, "Effective May 31, 2017, the device will only be available in clinical register setting at select sites/institutions that will play a pivotal role in the monitoring of this technology until Summer 2018 at which time the situation will be reviewed.". This morning Abbott reacted to this initial flurry of reports that they had "pulled the Absorb" with some clarification: specifically that the Absorb is NOT being pulled from the market and still retains the CE Mark. An Abbott spokesperson ...
An ultra thin walled wire reinforced endotracheal tubing includes a thin walled tubing comprising a polymeric material having a spring material incorporated therewith. Utilization of the spring wire material in combination with polymeric material results in a reduced wall thickness which results in a significant decrease in resistance to air flow through the endotracheal tubing. The endotracheal tubing of the present invention is made by depositing a dissolvable polymeric material on a rotating mandrel in. successive layers. A spring material is also applied around the mandrel to produce the ultra thin walled wire reinforced endotracheal tubing. By controlling the rate of deposition of polymeric material along the length of the mandrel, different wall thicknesses of tubing may be achieved.
Polymeric Materials | Scientific research info incl meetings, conferences, seminars, symposia,tradeshows,jobs,jobfairs, professional tips and more.
... decompose into natural byproducts. Polymers such as PLA, PCL, PLGA, PEG and their copolymers are useful in drug delivery, medical devices and other applications.
Definition of guided tissue regeneration in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is guided tissue regeneration? Meaning of guided tissue regeneration as a legal term. What does guided tissue regeneration mean in law?
Before Its News). Market Research Store has been recently published a fresh research report titled "World Lactic Acid and Polylactic Acid (PLA) Market Research Report 2021(covering USA, China, Japan, SEA, India and others)". This added to the companys collection of research reports. This report offers a deep examination of the Lactic Acid and Polylactic Acid (PLA) Market for the period 2013-2023. As per the report, the Lactic Acid and Polylactic Acid (PLA) Market is estimated to grow at elevated CAGR recorded in 2017. The towering competitive Lactic Acid and Polylactic Acid (PLA) Market has been observing huge and whooping investments in development and research from government as well as private firms. The report will also supply information on startup issues including obtaining permits, securing financing and business planning.. Lactic Acid and Polylactic Acid (PLA) Market research report provides the newest industry data and industry future trends, allowing you to identify the products and ...
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Scientific, peer-reviewed Dermatology article, indexed with MEDLINE/PubMed: Treatment Options in Facial and Nonfacial Volumization: An Introduction to Poly-L-Lactic Acid : Restoring Facial Volume: The Growing Impact of Poly-L-Lactic Acid Soft tissue augmentation is an important option in aesthetic enhancement and continues to grow in popularity for a number of reasons, including its minimally invasive nature and ability to directly nullify volume loss associated with facial ageing. Cosmetic agents that replace collagen are effective tools for addressing volume loss, and among these poly-L-lactic acid (PLLA) carries great potential, acting to volumize soft tissue in a gradual, progressive, and predictable manner, and providing natural-looking restoration of lost facial volume. In the considerable time that has passed since the introduction of PLLA for soft tissue augmentation, methodology and patient selection has improved, leading to far fewer adverse events such as nodules or papules and better
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth. The polymer scaffold may be produced using pure polymer or alternatively a composite material may be formed consisting of a macroporous polymer scaffold and osteoclast-resorbable calcium phosphate particles with a binding agent binding the calcium phosphate particles to the polymer scaffold.
DOI: 10.11607/prd.00.0411 The aim of the present study was to compare the postsurgical outcome of two different modes of surgical root coverage of predominantly shallow, Class I or II, gingival recessions. Fourteen facial recessions in nine patients were subjected to a coronally repositioned flap in combination with a bioresorbable membrane, and 14 sites in 13 patients were treated with a connective tissue graft employing an envelope technique. Immediately before surgery and after 6 and 12 months, gingival dimensions as well as root coverage and attachment gain were assessed. At baseline, mean recession depths amounted to 2.77 1.67 mm and 2.49 1.07 mm for patients treated with a bioresorbable membrane and a free connective tissue graft, respectively. Acceptable and stable root coverage of 81% to 82% of baseline recession depth and 78% of its width was achieved by grafting. In contrast, guided tissue regeneration (GTR) resulted in only 50% coverage of recession depth and, after 12 months, only ...
A Prospective Randomized Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS element) for the Treatment of up to Two De Novo Coronary Artery Lesions - PLATINUM Trial

Scientists Create Bio-absorbable Implant to Seal Hole in HeartScientists Create Bio-absorbable Implant to Seal Hole in Heart

... avoiding the need for open-heart surgery or metal implants. ... British scientists have created a novel bio-absorbable implant ... Scientists Create Bio-absorbable Implant to Seal Hole in Heart. by VR Sreeraman on August 13, 2007 at 6:03 PM General Health ... British scientists have created a novel bio-absorbable implant that uses the bodys natural building materials to seal a hole ... During the trials, the new bio-absorbable implant effectively sealed holes in more than 50 patients without causing any side ...
more infohttp://www.medindia.net/news/Scientists-Create-Bio-absorbable-Implant-to-Seal-Hole-in-Heart-24938-1.htm

Browsing Research in Reproduction and Contraception, Center for by Subject Absorbable ImplantsBrowsing Research in Reproduction and Contraception, Center for by Subject "Absorbable Implants"

... 0-9. A. B. C. D. E. F. G. H. ... suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men  ...
more infohttps://digital.lib.washington.edu/researchworks/handle/1773/15603/browse?value=Absorbable+Implants&type=subject

EXTEND Absorbable Synthetic ImplantsEXTEND Absorbable Synthetic Implants

EXTEND is an absorbable synthetic punctal implant that provides occlusion up to three months. It is packaged 20 implants per ... EXTEND is an absorbable synthetic punctal implant that provides occlusion up to three months. It is packaged 20 implants per ... BioScrew® Bio-Absorbable Interference Screws. 9. TwinFix AB Absorbable Suture Anchor. 10. INSTAT Collagen Absorbable Hemostat. ... Surgicel Nu-Knit Absorbable Hemostat. 6. PHANTOM Absorbable Cannulated Interference Screws. 7. ABSOLUTE Absorbable Cannulated ...
more infohttp://www.bio-medicine.org/medicine-products/EXTEND-Absorbable-Synthetic-Implants-16593-1/

LATERA Absorbable Nasal Implant | CEENTALATERA Absorbable Nasal Implant | CEENTA

CEENTA ENT doctors offer the LATERA Absorbable Nasal Implant for patients who suffer from nasal airway obstruction caused by ... CEENTA ENT doctors offer the LATERA Absorbable Nasal Implant for patients who suffer from nasal airway obstruction caused by ... What does the LATERA implant treat, and how does it work?. The implant is designed to treat a collapse of the lateral/side wall ... The implant can be performed by itself under local anesthesia, or the procedure can be done simultaneously with nasal turbinate ...
more infohttps://www.ceenta.com/conditions-and-treatments/latera-absorbable-nasal-implant

Development of Sponge Structure and Casting Conditions for Absorbable Magnesium Bone Implants | SpringerLinkDevelopment of Sponge Structure and Casting Conditions for Absorbable Magnesium Bone Implants | SpringerLink

Absorbable, open-pored implants minimize these risks. Synthetic bone implants are typically made of ceramics, bioglass or ... Development of Sponge Structure and Casting Conditions for Absorbable Magnesium Bone Implants. ... Development of Sponge Structure and Casting Conditions for Absorbable Magnesium Bone Implants. In: TMS T. (eds) TMS 2017 146th ... In order to adapt the degradation behavior to the bones ingrowth behavior, the implant material has to be alloyed and coated. ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-51493-2_29

Comparison Between Absorbable and Non Absorbable Scleral Implants in Deep Sclerectomy (T-Flux and SK-Gel) - Mid-Term Results |...Comparison Between Absorbable and Non Absorbable Scleral Implants in Deep Sclerectomy (T-Flux and SK-Gel) - Mid-Term Results |...

Comparison Between Absorbable and Non Absorbable Scleral Implants in Deep Sclerectomy (T-Flux and SK-Gel) - Mid-Term Results ... Comparison Between Absorbable and Non Absorbable Scleral Implants in Deep Sclerectomy (T-Flux and SK-Gel) - Mid-Term Results ... Comparison Between Absorbable and Non Absorbable Scleral Implants in Deep Sclerectomy (T-Flux and SK-Gel) - Mid-Term Results. ... 81 patients received T-Flux implants (group 1) and 35 patients received SK-Gel implants (group 2). Examinations were carried ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2383700

Re-absorbable breast implants to replace silicon - Corriere.itRe-absorbable breast implants to replace silicon - Corriere.it

An absorbable breast implant system to remove the silicone and improve the post-operation lives of women affected by cancer: ... Re-absorbable breast implants to replace silicon. Tensives patent will be in a preclinical phase by 2015, promising to ... the certification process and marketing of absorbable implants has reached a stage of profound acceleration. Now being tested ... reconstruction requires a single operation and will not need to undergo periodic replacement of the implants. Our implants , ...
more infohttp://en.corriereinnovazione.corriere.it/italian-ecosystem/2014/9-dicembre-2014/re-absorbable-breast-implants-to-replace-silicon-230697819862.shtml

Extend Absorbable Synthetic Implants 0.5mm X 2.0mm Default - Shophthalmics.comExtend Absorbable Synthetic Implants 0.5mm X 2.0mm Default - Shophthalmics.com

These implants are ideal for the transient dry eye associated with LASIK or other ocular surgeries. Extend implants can also be ... Extend Absorbable Synthetic Implants provide occlusion for up to 3 months for patients experiencing short-term dry eye symptoms ... Extend 180 Absorbable Synthetic Implants 0.4mm X 2.0mm Extend Absorbable Synthetic Implants provide occlusion for up to 6 ... Extend 180 Absorbable Synthetic Implants 0.5mm X 2.0mm Extend Absorbable Synthetic Implants provide occlusion for up to 6 ...
more infohttps://shophthalmics.com/products/extend-absorbable-synthetic-implants-0-5mm-x-2-0mm

ASTM F2502 - 17 Standard Specification and Test Methods for  Absorbable Plates and Screws for Internal Fixation ImplantsASTM F2502 - 17 Standard Specification and Test Methods for Absorbable Plates and Screws for Internal Fixation Implants

... absorbable, bend testing, bone plates, bone screw, conditioning, dimensions, insertion, pullout, shear, torsion,, ... 17 Standard Specification and Test Methods for Absorbable Plates and Screws for Internal Fixation Implants , ... F2902 Guide for Assessment of Absorbable Polymeric Implants. F3160 Guide for Metallurgical Characterization of Absorbable ... 4.1 Absorbable devices are intended to degrade and absorb over time once they are implanted into the body. This makes a removal ...
more infohttps://www.astm.org/Standards/F2502.htm

NLM Classification 2015 Edition . NLM Technical Bulletin. 2015 May-JunNLM Classification 2015 Edition . NLM Technical Bulletin. 2015 May-Jun

Absorbable Implants. *Aneurysm, Dissecting -- WG 580. *Aneurysm, False -- WG 580 *Aortic Aneurysm, Abdominal -- WG 410 ...
more infohttps://www.nlm.nih.gov/pubs/techbull/mj15/mj15_nlm_classification_2015.html

Patent US6602282 - Flexible stent structure - Google PatentsPatent US6602282 - Flexible stent structure - Google Patents

Magnesium-based absorbable implants. US9005274. 7 Oct 2008. 14 Apr 2015. Stentys Sas. Method for treating a body lumen. ... Thermo-mechanically controlled implants and methods of use. US8986362. 22 May 2009. 24 Mar 2015. J.W. Medical Systems Ltd.. ... Thermo-mechanically controlled implants and methods of use. US9474642. 10 May 2004. 25 Oct 2016. Sanostec Corp. Nasal ... Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft. ...
more infohttp://www.google.com.au/patents/US6602282

Dimensional ridge alterations following socket preservation using a nanocrystalline hydroxyapatite paste: a histomorphometrical...Dimensional ridge alterations following socket preservation using a nanocrystalline hydroxyapatite paste: a histomorphometrical...

Absorbable Implants. Alveolar Bone Loss / etiology, prevention & control. Alveolar Process / drug effects, pathology, surgery* ... The role of non-resorbed hydroxyapatite remnants for implant placement is unclear and requires further investigation.. ...
more infohttp://www.biomedsearch.com/nih/Dimensional-ridge-alterations-following-socket/18554868.html

Staple-Line Reinforcement for Prevention of Pulmonary Air LeakageStaple-Line Reinforcement for Prevention of Pulmonary Air Leakage

absorbable vegetal biopolymer in the form of sleeves, CE marked and indicated for prevention. of air leakage after pulmonary ... Absorbable implants. *Humans. *Alginates. *Pneumonectomy/methods. *Pneumonectomy/instrumentation. *Surgical Stapling. *Thoracic ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00925444/

Patent US20020035324 - Subcutaneous cavity marking device and method - Google PatentsPatent US20020035324 - Subcutaneous cavity marking device and method - Google Patents

Absorbable implant materials having controlled porosity. US5871501 *. Jan 12, 1998. Feb 16, 1999. Datascope Investment Corp.. ... Post-biopsy cavity treatment implants and methods. US8157862. Dec 10, 2010. Apr 17, 2012. Senorx, Inc.. Tissue marking implant ... Tissue marking implant. US9042965. Mar 6, 2013. May 26, 2015. C. R. Bard, Inc.. Biopsy marker with in situ-generated imaging ... Implant with electrical transponder marker. US5301682 *. Sep 22, 1992. Apr 12, 1994. Elie Debbas. Method for locating a breast ...
more infohttp://www.google.com/patents/US20020035324?dq=6679960

Product ClassificationProduct Classification

Cardiovascular implants and extracorporeal systems - Cardiovascular absorbable implants.. *3-143 ISO 12417 First edition 2015- ... Standard Guide for Testing Absorbable Stents. *3-138 ASTM F2942-13 Standard Guide for the In Vitro Axial, Bending, and ...
more infohttps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPCD/classification.cfm?ID=NIQ

Drug-eluting stents to prevent stent thrombosis and restenosis. - NextBio articleDrug-eluting stents to prevent stent thrombosis and restenosis. - NextBio article

Absorbable Implants Coated Materials, Biocompatible Coronary Restenosis Drug-Eluting Stents Humans Immunosuppressive Agents ...
more infohttp://www.nextbio.com/b/search/article.nb?id=26567863

Patent US7811252 - Dosage control device - Google PatentsPatent US7811252 - Dosage control device - Google Patents

Apparatus for providing living beings with absorbable implants. US4265618. Sep 9, 1977. May 5, 1981. Solar Energy Technology, ... Root canal implant-proximity indicative-delivery means. WO1993002720A1. Aug 6, 1992. Feb 18, 1993. Senetek Plc. Medicament ...
more infohttp://www.google.com/patents/US7811252?dq=6721967

General Principles of Internal Fixation: History of Fracture Treatment, Fracture Repair Biology, Pins, Wires, and ScrewsGeneral Principles of Internal Fixation: History of Fracture Treatment, Fracture Repair Biology, Pins, Wires, and Screws

Absorbable implants for the fixation of fractures. J Bone Joint Surg Am. 1991 Jan. 73(1):148-53. [Medline]. ... Current bioabsorbable implants do not have mechanical properties to match metallic implants; therefore, their indications are ... IM implants provide stable fixation, but healing occurs primarily through the formation of periosteal callus. Reaming of the ... Positional or neutralization screws are to attach an implant, such as a plate, to bone by compression between the plate and ...
more infohttps://emedicine.medscape.com/article/1269987-overview

Patent US20080294039 - Assembly with hemostatic and radiographically detectable pellets - Google PatentsPatent US20080294039 - Assembly with hemostatic and radiographically detectable pellets - Google Patents

Absorbable implant materials having controlled porosity. US5871501 *. 12 Jan 1998. 16 Feb 1999. Datascope Investment Corp.. ... Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants ... Implant cannula having an implant and a method for securing implants in an injection cannula. ... Implant Cannula Having an Implant and a Method for Securing Implants in an Injection Cannula. ...
more infohttp://www.google.com.au/patents/US20080294039

Extracellular matrix - WikipediaExtracellular matrix - Wikipedia

An entirely absorbable implant is currently under development.. *^ Kleinman HK, Luckenbill-Edds L, Cannon FW, Sephel GC ( ...
more infohttps://en.wikipedia.org/wiki/Extracellular_matrix

EP2189169B1 - Coated biodegradable metallic implantable device 
        - Google PatentsEP2189169B1 - Coated biodegradable metallic implantable device - Google Patents

Magnesium-based absorbable implants Families Citing this family (38). * Cited by examiner, † Cited by third party. Publication ... Implant having porous surface structure USD827824S1 (en) * 2013-04-30. 2018-09-04. Ostomycure As. Implant with internal porous ... Medical implant, coating method and implantation method DE102010018541A1 (en) * 2010-04-28. 2011-11-03. Acandis Gmbh & Co. Kg. ... Self-buffering medical implants US8303643B2 (en) 2001-06-27. 2012-11-06. Remon Medical Technologies Ltd.. Method and device for ...
more infohttps://patents.google.com/patent/EP2189169B1/en

US20110034991A1 - Endoprosthesis and method for producing same 
        - Google PatentsUS20110034991A1 - Endoprosthesis and method for producing same - Google Patents

Implant with an absorbable by the body metallic material US8668732B2 (en) 2010-03-23. 2014-03-11. Boston Scientific Scimed, Inc ... Magnesium-based absorbable implants Families Citing this family (33). * Cited by examiner, † Cited by third party. Publication ... Implant with attached element and method of making such an implant US20040015229A1 (en) * 2002-07-22. 2004-01-22. Syntheon, Llc ... Implant with attached element and method of making such an implant US20030121148A1 (en) * 2000-10-26. 2003-07-03. Scimed Life ...
more infohttps://patents.google.com/patent/US20110034991A1/en

Patent search - Patent Attorneys - Patent Applications - Patent SalePatent search - Patent Attorneys - Patent Applications - Patent Sale

Magnesium-based absorbable implants. An implantable tissue filler including a particulate material suspended in a carrier, the ... Various configurations of shielding materials within shielding layers, such as for use in shielding radiation from implanted ...
more infohttp://www.patents.com/search?keyword=carriers&page=60
  • In order to adapt the degradation behavior to the bone's ingrowth behavior, the implant material has to be alloyed and coated. (springer.com)
  • 4.3 Absorbable devices will be tested using test methods that are similar to those used to evaluate conventional metallic devices. (astm.org)
  • These implants swell 2-3 times their original size. (shophthalmics.com)
  • 1.2 This specification establishes a common terminology to describe the size and other physical characteristics of absorbable implants and performance definitions related to the performance of absorbable devices. (astm.org)