(1/74) Gestational regulation of granulocyte-colony stimulating factor receptor expression in the human placenta.

A number of cytokines and their receptors are abundantly expressed at the materno-fetal interface and are thought to have a function in the regulation of placentation. Granulocyte-colony stimulating factor (G-CSF) is expressed by stromal cells in both placental tissue and maternal decidua throughout placentation. In this study, we examined the expression of placental G-CSF receptor (G-CSFR) mRNA and protein throughout gestation by ribonuclease protection assays, Western blotting, and immunohistochemistry. The major placental form of G-CSFR mRNA, corresponding to a membrane-bound form of the protein, was present in first-trimester placental tissues; levels decreased in second- and were highest in third-trimester placental tissues. Two placental G-CSFR molecules, 120 kDa and 150 kDa, were detected in first- and third-, but not second-, trimester tissues. The level of the 150-kDa G-CSFR was greater in the third- than in first-trimester samples. These differences were irrespective of whether or not the patients had received prostaglandin E1 analogues, prostaglandin E1 analogues and oxytocin, oxytocin alone, or mifepristone before labor. We demonstrated by immunohistochemistry that interstitial cytotrophoblast in first- and second-trimester decidual tissue and cytotrophoblast in term fetal membranes express G-CSFR. These data demonstrate that the expression of specific forms of placental G-CSFR is strictly cell type- and developmental stage-specific, and they suggest that G-CSFR may be important in decidual invasion of cytotrophoblast and in trophoblast function during placentation.  (+info)

(2/74) A randomized double-blind placebo-controlled study to assess the effect of oral contraceptive pills on the outcome of medical abortion with mifepristone and misoprostol.

This was a randomized double-blind placebo-controlled trial to determine the effect of oral contraceptive (OC) pills taken immediately after medical abortion on the duration of bleeding and complete abortion rate. Two hundred women in the first 49 days of pregnancy were given 200 mg mifepristone orally followed by 400 microg misoprostol vaginally 48 h later. One day later, they were randomized to receive either OC pills (30 microg of ethinyl oestradiol and 0.15 mg of levonorgestrel per tablet) or placebo for 21 days. The complete abortion rates were 98% in the OC group and 99% in the placebo group. The median duration of bleeding was similar: 17 (range: 5-57) days in the OC group and 16 (range: 6-55) days in the placebo group. In the OC group there was a small but significant fall in the haemoglobin concentration by 14 days (5.3 g/dl) after administration of mifepristone. The incidence of side-effects was similar in the two groups. We conclude that the use of OC pills does not decrease the duration of bleeding after medical abortion nor does it affect the abortion rate.  (+info)

(3/74) German drug agency approves mifepristone.

 (+info)

(4/74) Fear of black market means no RU-486 for Canada until US approves drug.

Mifepristone, the "abortion pill" that is better known as RU-486, is no closer to arriving in Canada than it was 8 years ago. But that fact hasn't slowed debate about the product.  (+info)

(5/74) Medical abortion still not available in most countries.

 (+info)

(6/74) Troglitazone prevents and reverses dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocytes.

Troglitazone lowers blood glucose levels in Type II diabetic patients. To evaluate the insulin sensitizing action of troglitazone on glycogen synthesis we have used dexamethasone-treated 3T3 adipocytes as an in vitro model. Differentiated 3T3 adipocytes were incubated with 100 nM dexamethasone for 6 days. Troglitazone (1.0 microM) or metformin (1.0 mM) with or without 200 nM insulin was added during the last 4 days. At the end, insulin (100 nM) stimulated glycogen synthesis was determined using (14)C-glucose. Dexamethasone caused a 50% reduction in glycogen synthesis. Troglitazone caused an approximately 3 fold increase in glycogen synthesis from 43.9+/-3.4 to 120+/-16.2 nmols h(-1). Under identical conditions metformin had no significant effect. When cells were incubated with troglitazone and dexamethasone simultaneously for 6 days, troglitazone but not metformin completely prevented dexamethasone-induced insulin resistance. RU 486 (1.0 microM) also completely prevented the insulin resistance. Chronic incubation with dexamethasone and insulin resulted in a 73% reduction in glycogen synthesis. In these adipocytes, troglitazone was partially active with glycogen synthesis rising from 23.1+/-3.0 to 44.4+/-4.5 nmol h(-1), P<0.01 while metformin was inactive. Troglitazone stimulated 2-deoxyglucose uptake by 2 - 3 fold in dexamethasone-treated adipocytes. Metformin also increased glucose uptake significantly. Troglitazone did not affect insulin binding while a 2 fold increase was observed in normal adipocytes where it exhibited a modest effect. Since the effect of troglitazone was greater in dexamethasone-treated adipocytes, troglitazone is likely to act by preventing dexamethasone-induced alterations which may include (i) binding to glucocorticoid receptor and (ii) effect on glucose uptake. These data demonstrate the direct insulin sensitizing action of troglitazone on glycogen synthesis and suggest a pharmacological profile different from metformin.  (+info)

(7/74) The effect of mifepristone administration on leukocyte populations, matrix metalloproteinases and inflammatory mediators in the first trimester cervix.

Cervical ripening is analogous to an inflammatory reaction characterized by an influx of inflammatory cells and an increase in inflammatory mediators. The anti-gestogen mifepristone is highly effective in inducing cervical ripening in women throughout gestation. However, its mechanism of action is largely unknown. The aim of the study was to investigate the effect of in-vivo administration of mifepristone on inflammatory cells and mediators in the cervix. Cervical biopsies were taken from women undergoing a first trimester termination of pregnancy at 0, 6, 12, 24 and 36 h (n = 6 per group) after mifepristone administration. Biopsies were fixed for immunohistochemistry and also cultured for subsequent analysis of culture media by radioimmunoassay or enzyme-linked immunosorbent assay. After administration of mifepristone (6-24 h), there was an increase in immunostaining for leukocyte common antigen (CD45), neutrophil elastase, monocytes (CD68), and matrix metalloproteinases (MMP)-1, -8 and -9. Immunostaining for MMP-2 and tissue inhibitor of metalloproteinases (TIMP)-1, -2 and -4 were unaffected by mifepristone treatment. Secretion of monocyte chemotactic protein (MCP-1) was significantly (P < 0.05) increased from biopsies taken 6-24 h after mifepristone administration. Cervical biopsies also released interleukin-8 (IL-8), prostaglandin (PG) E(2), PGF(2alpha) and prostaglandin metabolites (PGEM and PGFM) although their secretion was unaffected by mifepristone treatment. This study suggests that mifepristone may, in part, effect cervical ripening by modulating the influx of inflammatory cells into the cervix, up-regulating MMP expression and inducing chemokine secretion by cervical tissue.  (+info)

(8/74) Randomized comparison of vaginal (200 microg every 3 h) and oral (400 microg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy.

It is known that when misoprostol is given at 200 microg every 3 h after mifepristone pretreatment, the vaginal route is more effective than the oral route. However, women prefer the oral route. This randomized study was to test our hypothesis that oral misoprostol 400 microg is as effective as vaginal misoprostol 200 microg when given every 3 h in termination of second trimester pregnancy after priming with mifepristone. A total of 142 patients was randomly assigned to group 1 (200 mg mifepristone + 400 microg oral misoprostol every 3 h up to five doses) or group 2 (200 mg mifepristone + 200 microg vaginal misoprostol every 3 h up to five doses). The incidence of side-effects and the preference study were assessed through a standardized questionnaire during and after the abortion. For the oral group, both the incidence of diarrhoea (40.0 versus 23.2%, P = 0.03) and the amount of drug used (1734 compared with 812 microg, P < 0.0001) were significantly higher than that of the vaginal group but the incidence of fever appeared to be lower (not significant). There was no significant difference in complete abortion rate: 81.4% in the oral group and 75.4% in the vaginal group. The median induction-abortion interval was similar in the two groups (10.4 versus 10.0 h). The percentage of women who aborted in 24 h was also similar: 57/70 (81.4%) in the oral group and 58/69 (87.0%) in the vaginal group. Overall, 82.0% of women preferred the oral route. Oral misoprostol (400 microg) given every 3 h up to five doses, when combined with mifepristone, was as effective as the vaginal (200 microg) route in second trimester termination of pregnancy. This regimen could also be offered to those women who found repeated vaginal administration unacceptable.  (+info)

*  List of MeSH codes (D16)
... abortifacient agents, nonsteroidal MeSH D27.505.696.875.131.200 --- abortifacient agents, steroidal MeSH D27.505.696.875.360 ... abortifacient agents, nonsteroidal MeSH D27.505.954.705.131.200 --- abortifacient agents, steroidal MeSH D27.505.954.705.360 ... uricosuric agents MeSH D27.505.954.705 --- reproductive control agents MeSH D27.505.954.705.131 --- abortifacient agents MeSH ... photosensitizing agents MeSH D27.505.696.875 --- reproductive control agents MeSH D27.505.696.875.131 --- abortifacient agents ...
*  Methotrexate
... is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in ... Recently, use of methotrexate in combination with anti-TNF agents has been shown to be effective for the treatment of ... Colebatch, AN (2011). "Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in ... Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant. It is used to treat ...
*  Mifepristone
... is a steroidal antiprogestogen (IC50 = 0.025 nM for the PR), as well as an antiglucocorticoid (IC50 = 2.2 nM for ... Use as a cervical ripening agent has also been described. Mifepristone has been studied as an antiandrogen in the treatment of ... It does not prevent fertilization or implantation, so technically it is an ABORTIFACIENT rather than a contraceptive. excluding ... n. A contragestive drug or agent. Ammer, Christine (2009). "contragestive". The encyclopedia of women's health (6th ed.). New ...
Mifepristonum [Latin]
        -
        Menstruation-Inducing Agents,  Luteolytic Agents,  Contraceptives, Oral, Synthetic, ...  Mifepristonum [Latin] - Menstruation-Inducing Agents, Luteolytic Agents, Contraceptives, Oral, Synthetic, ...
Abortifacient Agents, Steroidal. * ATC:G03XB01. Mifepristonum [Latin] Brand names, Mifepristonum [Latin] Analogs *Mifegyne ...
more infohttp://pharmacycode.com/Mifepristonum_%5BLatin%5D.html
S9005 Mifepristone in Meningioma - Full Text View - ClinicalTrials.gov  S9005 Mifepristone in Meningioma - Full Text View - ClinicalTrials.gov
Abortifacient Agents, Steroidal. Abortifacient Agents. Reproductive Control Agents. Physiological Effects of Drugs. ... Contraceptive Agents, Female. Contraceptive Agents. Contraceptives, Postcoital, Synthetic. Contraceptives, Postcoital. Hormone ... Double Blind Randomized Trial of the Anti-Progestational Agent Mifepristone In The Treatment of Unresectable Meningioma. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03015701
Mifepristone Treatment of Alcohol Use Disorder - Full Text View - ClinicalTrials.gov  Mifepristone Treatment of Alcohol Use Disorder - Full Text View - ClinicalTrials.gov
Abortifacient Agents, Steroidal. Abortifacient Agents. Reproductive Control Agents. Contraceptives, Oral, Synthetic. ... Anti-Infective Agents, Local. Anti-Infective Agents. Central Nervous System Depressants. Physiological Effects of Drugs. ... Contraceptive Agents, Female. Contraceptive Agents. Contraceptives, Postcoital, Synthetic. Contraceptives, Postcoital. Hormone ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02179749?term=Mifepristone+Treatment+of+alcohol+Use+Disorder&
A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features - Full Text View...  A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features - Full Text View...
Abortifacient Agents, Steroidal. Abortifacient Agents. Reproductive Control Agents. Physiological Effects of Drugs. ... Contraceptive Agents, Female. Contraceptive Agents. Contraceptives, Postcoital, Synthetic. Contraceptives, Postcoital. Hormone ... Have received investigational therapy (drug, vaccine, biological agent or device) within 6 months prior to randomization ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00637494
A Category Names List - Drug Information Portal - U.S. National Library of Medicine  A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Abortifacient Agents (16). Abortifacient Agents, Nonsteroidal (13) • Non-steroidal chemical compounds with abortifacient ... Abortifacient Agents, Steroidal (3) • Steroidal compounds with abortifacient activity. MeSH. Acaricides (4) • A pesticide or ... Anti-Inflammatory Agents, Non-Steroidal (251) • Anti-inflammatory agents that are non-steroidal in nature. In addition to anti- ... Anti-Rheumatic Agents, Non-Steroidal (0) see Anti-Inflammatory Agents, Non-Steroidal ...
more infohttps://druginfo.nlm.nih.gov/drugportal/drug/categories
Medical versus surgical termination of pregnancy in primigravid women--is the next delivery differently at risk? A population...  Medical versus surgical termination of pregnancy in primigravid women--is the next delivery differently at risk? A population...
Abortifacient Agents, Nonsteroidal / adverse effects. Abortifacient Agents, Steroidal / adverse effects. Abortion, Induced / ... 0/Abortifacient Agents, Nonsteroidal; 0/Abortifacient Agents, Steroidal; 0/Drug Combinations; 59122-46-2/Misoprostol; 84371-65- ...
more infohttp://www.biomedsearch.com/nih/Medical-versus-surgical-termination-pregnancy/23126244.html
A Category Names List - Drug Information Portal - U.S. National Library of Medicine  A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Abortifacient Agents (16). Abortifacient Agents, Nonsteroidal (13) • Non-steroidal chemical compounds with abortifacient ... Abortifacient Agents, Steroidal (3) • Steroidal compounds with abortifacient activity. MeSH. Acaricides (4) • A pesticide or ... Anti-Inflammatory Agents, Non-Steroidal (251) • Anti-inflammatory agents that are non-steroidal in nature. In addition to anti- ... Anti-Rheumatic Agents, Non-Steroidal (0) see Anti-Inflammatory Agents, Non-Steroidal ...
more infohttps://druginfo.nlm.nih.gov/drugportal/jsp/drugportal/drugNamesAndCategories.jsp
Trilostane - DrugBank  Trilostane - DrugBank
Abortifacient Agents. *Abortifacient Agents, Steroidal. *Adrenal Cortex Hormones. *Androstanes. *Androstanols. *Antiadrenal ...
more infohttps://www.drugbank.ca/drugs/DB01108
trilostane - Semantic Scholar  trilostane - Semantic Scholar
Abortifacient Agents, Steroidal. Antineoplastic Agents. Dihydrotestosterone. Enzyme Inhibitors. analogs & derivatives. Papers ...
more infohttps://www.semanticscholar.org/topic/trilostane/582186
Misoprostolum [Inn-Latin]
        -
        Oxytocics,  Anti-ulcer Agents,  Abortifacient Agents,  Prostaglandins,  ATC:A02BB01  Misoprostolum [Inn-Latin] - Oxytocics, Anti-ulcer Agents, Abortifacient Agents, Prostaglandins, ATC:A02BB01
It is sometimes co-prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) to prevent the occurrence of gastric ...
more infohttp://pharmacycode.com/Misoprostolum_%5BInn-Latin%5D.html
Evidence Central | By Topic A  Evidence Central | By Topic A
Abortifacient Agents. *Abortifacient Agents, Nonsteroidal. *Abortifacient Agents, Steroidal. *Abortion, Eugenic. *Abortion, ...
more infohttps://evidence.unboundmedicine.com/evidence/index/Cochrane/By_Topic/A
Liste alphabétique			- TermSciences
		  Liste alphabétique - TermSciences
Abortifacient Agents. *Abortifacient Agents, Nonsteroidal. *Abortifacient Agents, Steroidal. *Air Abrasion, Dental. *Abreaction ...
more infohttp://inserm.termsciences.fr/-/Index/Explorer/Alphabet/
Adrenergic beta-Agonists  Adrenergic beta-Agonists
Abortifacient Agents. Abortifacient Agents, Nonsteroidal. Abortifacient Agents, Steroidal. ACE Inhibitors and Calcium Channel ...
more infohttp://www.genericdrugscan.com/drug-category/adrenergic-beta-agonists
Acetylcholine Release Inhibitors<span class=...  Acetylcholine Release Inhibitors<span class=...
Abortifacient Agents. Abortifacient Agents, Nonsteroidal. Abortifacient Agents, Steroidal. ACE Inhibitors and Calcium Channel ...
more infohttp://www.genericdrugscan.com/drug-category/acetylcholine-release-inhibitors
conditions: Ab  conditions: Ab
Abortifacient Agents. *Abortifacient Agents, Non Steroidal. *Abortifacient Agents, Non-Steroidal. *Abortifacient Agents, ...
more infohttp://conditions.healthplace.com/sections/Ab
List of MeSH codes (D16) - Wikipedia  List of MeSH codes (D16) - Wikipedia
... abortifacient agents, nonsteroidal MeSH D27.505.696.875.131.200 --- abortifacient agents, steroidal MeSH D27.505.696.875.360 ... abortifacient agents, nonsteroidal MeSH D27.505.954.705.131.200 --- abortifacient agents, steroidal MeSH D27.505.954.705.360 ... uricosuric agents MeSH D27.505.954.705 --- reproductive control agents MeSH D27.505.954.705.131 --- abortifacient agents MeSH ... photosensitizing agents MeSH D27.505.696.875 --- reproductive control agents MeSH D27.505.696.875.131 --- abortifacient agents ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D16)
The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children - Full Text View - ClinicalTrials...  The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children - Full Text View - ClinicalTrials...
Abortifacient Agents, Nonsteroidal. Abortifacient Agents. Reproductive Control Agents. Physiological Effects of Drugs. ... Non-steroidal Anti-inflammatory Drugs (NSAIDs) such as Salicylates e.g. Aspirin, Selective COX-2 inhibitors e.g. Celecoxib & ... Antineoplastic Agents. Dermatologic Agents. Enzyme Inhibitors. Folic Acid Antagonists. Immunosuppressive Agents. Immunologic ... Antirheumatic Agents. Nucleic Acid Synthesis Inhibitors. Anti-Inflammatory Agents. Glucocorticoids. Hormones. Hormones, Hormone ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT03692416?term=vasculitis&
COX-2 inhibitors | definition of COX-2 inhibitors by Medical dictionary  COX-2 inhibitors | definition of COX-2 inhibitors by Medical dictionary
Should not be used by patients who have shown allergic reactions to other non-steroidal anti-inflammatory agents such as ... However, misoprostol is an abortifacient and has been associated with birth defects. For this reason, it may be inappropriate ... Although the non-steroidal anti-inflammatory drugs are considered relatively safe, they are so widely used that their adverse ... A study of prescription pattern of non steroidal anti-inflammatory drugs in medicine out-patient clinic of a rural teaching ...
more infohttp://medical-dictionary.thefreedictionary.com/COX-2+inhibitors
Moringa Oleifera the Miracle Plant  Moringa Oleifera the Miracle Plant
For centuries, many cultures have looked to Moringa as a general remedy and healing agent. It has been referred to as the ... Hormonal properties / Abortifacient: Biochemical observations and histologic findings have been correlated with the anti- ... Antimicrobial / Water Purifying: Study of MO seeds paste for water purification yielded a steroidal glycoside, strophantidin, a ... Isolated extracts could be of use for the future development of anti-skin disease agents. ...
more infohttp://www.shirleys-wellness-cafe.com/Herbal/Moringa
  • This prostaglandin, although not licensed for use in pregnancy termination, is now a common abortifacient with a large accumulated experience both within Australia and internationally. (clinicaltrials.gov)
  • The purpose of this study is to see whether this agent can improve diabetes or other symptoms of Cushing's syndrome in subjects with ectopic ACTH secretion. (clinicaltrials.gov)
  • In November 2007, the TGA (Therapeutic Goods Administration) approved an application by the Principal Investigator of this planned study for Authorised Prescriber status for use of the antiprogesterone agent mifepristone. (clinicaltrials.gov)