Abortifacient Agents: Chemical substances that interrupt pregnancy after implantation.Pinus ponderosa: A plant species of the genus PINUS that contains isocupressic acid.Abortifacient Agents, Nonsteroidal: Non-steroidal chemical compounds with abortifacient activity.Abortifacient Agents, Steroidal: Steroidal compounds with abortifacient activity.Trichosanthin: Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.Abortion, Veterinary: Premature expulsion of the FETUS in animals.Abortion, Induced: Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Disability Evaluation: Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.Pregnancy, Ectopic: A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Pregnancy, Tubal: The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.Maternal Mortality: Maternal deaths resulting from complications of pregnancy and childbirth in a given population.Pregnancy Complications: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)Auranofin: An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Apiaceae: A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.Acorus: A plant genus of the family ACORACEAE, order Arales, subclass Arecidae most notable for Acorus calamus L. root which contains asarone and has been used in TRADITIONAL MEDICINE.Pimenta: A plant genus in the family MYRTACEAE, order Myrtales, subclass Rosidae. It is best known for allspice from the dried berry of Pimenta diocia.Piper nigrum: A plant species in the PIPERACEAE plant family. It is a common spice on foods and is used medicinally to increase gastrointestinal assimilation of other supplements and drugs. Piperine is a key component. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water.Myrtaceae: The myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.Acoraceae: A plant family of the order Arales, subclass Arecidae, class Liliopsida (monocot).Black Pepper: A common spice from fruit of PIPER NIGRUM. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water. Piperine is a key component used medicinally to increase gastrointestinal assimilation of other supplements and drugs.Gravidity: The number of pregnancies, complete or incomplete, experienced by a female. It is different from PARITY, which is the number of offspring borne. (From Stedman, 26th ed)Labor Pain: Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.Pregnancy Complications, Parasitic: The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.Misoprostol: A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.Community Pharmacy Services: Total pharmaceutical services provided to the public through community pharmacies.Pharmacies: Facilities for the preparation and dispensing of drugs.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Pharmacy: The practice of compounding and dispensing medicinal preparations.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Fonofos: An organothiophosphorus cholinesterase inhibitor that is used as an insecticide.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Conductometry: Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)Abortion, Incomplete: Premature loss of PREGNANCY in which not all the products of CONCEPTION have been expelled.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Administration, Sublingual: Administration of a soluble dosage form by placement under the tongue.

Effect of DL111-IT on progesterone biosynthesis and viability of rat luteal cells in vitro. (1/197)

AIM: To study the influence of DL111-IT on progesterone biosynthesis of cultured luteal cells (LC). METHODS: LC viability was assessed with trypan blue dye exclusion and progesterone concentration was measured with radioimmunoassay. RESULTS: DL111-IT decreased the viability of LC after 24-h incubation, its ED50 being 7.7 (95% confidence limits: 7.1-8.5) mg.L-1. DL111-IT inhibited basal secretion of progesterone in a concentration-dependent manner, and 3 mg.L-1 decreased progesterone concentration by 25% vs control. DL111-IT 3 mg.L-1 also inhibited the stimulatory effect of forskolin (cAMP activator) 10 mumol.L-1 and pregnenolone [converted to progesterone by 3 beta-hydroxysteroid dehydrogenase-isomerase complex (3 beta-HSD)] 10 mumol.L-1 on progesterone production in cultured LC, and their inhibitory rates were 43% and 155%, respectively. At the same concentration, DL111-IT did not influence hCG-induced progesterone production. CONCLUSION: DL111-IT inhibited progesterone synthesis by suppressing the conversion of pregnenolone to progesterone (inactivating 3 beta-HSD) and suppressed the activity of cAMP. DL111-IT 6-24 mg.L-1 decreased the viability of LC.  (+info)

The effectiveness of non-surgical management of early interstitial pregnancy: a report of ten cases and review of the literature. (2/197)

OBJECTIVE: To assess the effectiveness of non-surgical management of interstitial pregnancy. DESIGN: A prospective interventional study. SUBJECTS: Eleven women with the ultrasound diagnosis of interstitial ectopic pregnancy. METHODS: Women with suspected early pregnancy complications were examined by transvaginal ultrasound. Those with the diagnosis of interstitial pregnancy were offered non-surgical treatment with methotrexate, which was administered systemically or by local injection. Follow-up with regular measurements of beta-human chorionic gonadotropin and ultrasound scans continued until the pregnancy had resolved completely. RESULTS: Ten women were managed non-surgically, and one woman opted for surgery. Five women received systemic and five local methotrexate. Local therapy was successful in all five cases (100%), whereas four out of five (80%) women receiving systemic methotrexate were cured. Significant side-effects were noted in two women following systemic therapy. In comparison, there were no side-effects in the group of women who received local therapy. There were no significant differences between the two treatment groups in the length of time taken for the pregnancy to resolve. CONCLUSIONS: Non-surgical treatment of interstitial pregnancy with methotrexate appears to be safe and effective. Local administration appears to be more successful and better tolerated by patients and may be used as the first-line therapy.  (+info)

Once-a-month treatment with a combination of mifepristone and the prostaglandin analogue misoprostol. (3/197)

In this two centre study, the efficacy of 200 mg mifepristone orally followed 48 h later by 0.4 mg misoprostol orally for menstrual regulation was investigated. The dose of mifepristone was taken the day before the expected day of menstruation. Each volunteer was planned to participate for up to 6 months. A plasma beta human chorionic gonadotrophin (HCG) was measured on the day of mifepristone intake. The study was disrupted prematurely due to low efficacy. In 125 treatment cycles the overall pregnancy rate was 17.6% (22 pregnancies) and the rate of continuing pregnancies (failure) was 4.0%. Eight women discontinued the study due to bleeding irregularities which were seen in 15 cycles (12%). These effects on bleeding pattern made the timing of treatment day difficult. Late luteal phase treatment with a combination of mifepristone and misoprostol is not adequately effective for menstrual regulation.  (+info)

Angiotensin II interacts with prostaglandin F2alpha and endothelin-1 as a local luteolytic factor in the bovine corpus luteum in vitro. (4/197)

Recent findings suggest that the ovarian renin-angiotensin system may regulate ovarian function through the paracrine/autocrine actions of angiotensin II (Ang II). In this study, we have examined and characterized the local effects of Ang II as a luteolytic factor and its interaction with prostaglandin F2alpha (PGF2alpha) and endothelin-1 (ET-1) in the bovine corpus luteum (CL) of the mid-luteal phase, by using an in vitro microdialysis system (MDS). Ang II was detected in the MDS perfusate (4 pg/ml), and infusion of PGF2alpha (10(-6) M) for 2 h increased the Ang II release by 50-100% during the following experimental period, in addition to its stimulation of ET-1 release. Two 2-h infusions of Ang II (10(-7)-10(-5) M) separated by a 2-h interval induced a dose- and time-dependent decrease of progesterone (P4) release by 41-66%. When the luteal explants were pre-perfused with PGF2alpha (10(-6) M) for 2 h, two consecutive perfusions of Ang II (10(-6) M) at a 2-h interval rapidly reduced the P4 release (by 50%). This reduction occurred 6 h earlier than those of infusions of PGF2alpha or Ang II alone. The simultaneous infusion of either 1) Ang II (10(-6) M) with PGF2alpha (10(-6) M), 2) ET-1 (10(-7) M) with PGF2alpha, or 3) Ang II + ET-1 with PGF2alpha (10(-6) M) for 2 h also induced a rapid and pronounced (60%) decrease in P4 release. Perfusion with the Ang II antagonist blocked the P4-suppressing activity of Ang II alone or PGF2alpha + Ang II infusion. Ang II stimulated the release of ET-1 and oxytocin during infusion but inhibited them after infusion. These results show that Ang II is released in the bovine midcycle CL in vitro, and this peptide, either alone or together with PGF2alpha, can suppress the release of P4. As PGF2alpha directly stimulated Ang II release, Ang II may influence the critical period for starting the cascade of functional luteolysis in vivo and might lead to structural luteolysis with ET-1 as a major vasoconstrictor. The overall results suggest that Ang II may have an important role at luteolysis in the bovine CL.  (+info)

Does an acidic medium enhance the efficacy of vaginal misoprostol for pre-abortion cervical priming? (5/197)

Absorption pharmacokinetics reveal a relationship between plasma concentrations of misoprostol and its therapeutic effect. To achieve a constant plasma profile and optimal efficacy, it is important to develop a medium that ensures complete dissolution of vaginal misoprostol tablets. Vaginal misoprostol is said to liquefy better in an acidic medium; thus, the aim of this study was to determine whether a 200 microg misoprostol tablet dissolved in acetic acid would be more efficacious than 200 microg misoprostol dissolved in water for pre-abortion cervical priming. A total of 120 healthy nulliparous women requesting legal termination of pregnancy between 6-12 weeks gestation were allocated randomly to either of the study groups. Vacuum aspiration was performed 3-4 h after insertion of the misoprostol tablet. Using Hegar's dilator, the degree of cervical dilatation before operation was measured. Of 60 women, 14 (23%) achieved a cervical dilatation of >/=8 mm when the misoprostol dose was dissolved in acetic acid; 12 (20%) achieved a similar cervical dilatation when the dose was dissolved in water. The mean cervical dilatation for the acid and water media used was 6.3 mm and 6.2 mm respectively; these differences were not statistically significant, neither were pre-operative and intra-operative blood losses statistically different between the two groups. Twenty-four (40%) and four (7%) respectively of women in whom a water medium was used experienced vaginal bleeding and abdominal pain; 20 (33%) and 0 women respectively among those in whom an acetic acid medium was used experienced vaginal bleeding and abdominal pain. These differences in side effects were not statistically significant. Our study shows that the use of acetic acid to dissolve vaginal misoprostol does not improve the efficacy in achieving successful cervical dilatation for pre-abortion cervical priming.  (+info)

The use of misoprostol for pre-operative cervical dilatation prior to vacuum aspiration: a randomized trial. (6/197)

Misoprostol is effective for cervical priming prior to vacuum aspiration for first trimester termination of pregnancy. Previous studies showed that the oral route was more acceptable to patients but there were higher incidences of side-effects when compared with the vaginal route. This study is to determine the optimal dosage and route of administration of misoprostol for pre-operative cervical dilatation. A double-blind, randomized trial was undertaken for 225 nulliparous women with 8-12 weeks amenorrhoea. They were randomly assigned to groups given 0 (placebo), 200 or 400 microg oral or vaginal misoprostol 3 h prior to vacuum aspiration. In misoprostol-treated groups the baseline cervical dilatation was significantly increased when compared with the placebo group; the effect was dose-related in the oral but not in the vaginal group. The cumulative force and blood loss was significantly decreased in the misoprostol-treated groups. The incidences of side-effects were more frequent in misoprostol groups but were not related to the route and dosage of medication. The duration of procedure, incidences of post-operative complications, the duration of post-operative bleeding and the interval to the first period were similar in the five treatment groups. We conclude that a 3 h pre-treatment interval is effective for both oral and vaginal routes. When given orally, 400 microg is more effective than 200 microg. The efficacy was otherwise similar when compared with the vaginal route. We recommend 400 microg oral misoprostol 3 h prior to vacuum aspiration for cervical dilatation.  (+info)

Induction of parturition in bitches with minimal side effects by two injections of a low dose of fenprostalene, a prostaglandin F2alpha analogue, and pretreatment with prifinium bromide. (7/197)

An experiment using 16 Beagle bitches (aged 11 months to 6 years and 2 months) in their 56th to 58th day of pregnancy was carried out to investigate the effects of two injections of a low dose of fenprostalene, a long-acting prostaglandin F2alpha analogue, and pretreatment with prifinium bromide, a parasympathetic nerve blocking agent, on the induction of parturition and severity of side effects. The bitches were divided into three treatment groups: one injection of 5 microg/kg of fenprostalene (group I, n=5); one injection of 7.5 mg/head of prifinium bromide followed by one injection of 5 microg/kg of fenprostalene at 5 min after prifinium bromide injection (group II, n=6); and one injection of 7.5 mg/head of prifinium bromide followed by two injections of 2.5 microg/kg of fenprostalene, one injection at 5 min after prifinium bromide injection and the next at 1 hr after the fenprostalene first injection (group III, n=5). Following the injection of fenprostalene, side effects such as salivation, vomiting, colic symptoms, and watery diarrhea occurred most frequently (80-100% of cases) in group I bitches. Apart from colic symptoms, no side effects were observed in group III bitches. Group III bitches also showed the smallest increase in plasma cortisol concentration. No significant difference in the time to initiation of parturition was found between the three groups. The one-week survival rate of newborn puppies was highest in group III. The results showed that pretreatment with prifinium bromide and two injections of 2.5 microg/kg of fenprostalene can alleviate side effects following fenprostalene administration and have no adverse effect on the survival of newborn puppies, indicating that this method is a reliable and safe way of inducing parturition in bitches.  (+info)

A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: a randomized comparative trial. (8/197)

A prospective randomized trial was conducted in 148 women to compare the efficacy of two regimens of vaginal misoprostol for termination of second trimester pregnancy. Women aged 16-40 years requesting termination of second trimester pregnancy were randomized into two groups. Women in group 1 were given vaginal misoprostol 400 microg every 3 h for a maximum of five doses in 24 h. Women in group 2 were given vaginal misoprostol 400 microg every 6 h for a maximum of three doses in 24 h. If women did not abort in 24 h, the same regimen was repeated. The median induction-abortion interval in group 1 (15.2 h) was significantly shorter (P < 0.01) than that in the group 2 (19.0 h). The percentage of women who achieved successful abortion within 48 h in group 1 (90.5%) was also significantly higher (P < 0.02) than that in group 2 (75.7%). The incidence of fever was more common in group 1 (P = 0.01). It is concluded that the regimen of vaginal misoprostol 400 microg every 3 h with maximum of five doses in 24 h was more effective than the regimen of misoprostol every 6 h in termination of second trimester pregnancy.  (+info)

Early pregnancy termination: a comparison between vacuum aspiration and medical abortion using prostaglandin (16,16 dimethyl-trans-delta 2-PGE1 methyl ester) or
The main purpose of our study was to which determine factors, those measured by ultrasound and also demographic and clinical factors (age, number of previous pregnancies, abortions and deliveries) predict outcome of medical treatment for early pregnancy failure. Our hypothesis was that gestational sac volume predicts outcome of medical treatment for early pregnancy failure ...
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Results: The success rate is greater in mifepristone with misoprostol group with 98% than misoprostol group with 90% Mean induction abortion interval from the insertion of the first misoprostol tablet is significantly shorter in the mifepristone pretreated group 12.93+4.19 hr as compared to 19.18+3.97 hr in the misoprostol alone group (p,0.001). The mean dose of the misoprostol required is significantly less in the mifepristone group as against misoprostol group (p=0.008). The side effects and complications observed in both the groups are mainly nausea vomiting, fever, abdominal cramps, bleeding, rigor, dizziness, retained products of consumption and these side effects are more in misoprostol group ...
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OBJECTIVE To compare the efficacy of 400 microg of misoprostol with that of 1 mg of gemeprost as cervical priming agents when administered vaginally 3 to 4 hours before first-trimester vacuum aspiration abortion. METHODS In a prospective controlled trial 90 nulliparous women who requested termination of pregnancy before 12 weeks gestation were randomized to receive vaginally either misoprostol or gemeprost for cervical priming. The force to dilate the cervix was measured by the use of a cervical tonometer connected to Hegar dilators from 3 to 10 mm. The main outcome measures were baseline cervical dilation; the peak force to dilate the cervix at 8, 9, and 10 mm; and the cumulative force to dilate the cervix to 10 mm. RESULTS Baseline cervical dilation did not differ significantly between the women who received misoprostol and those who were treated with gemeprost. Neither the peak force required to dilate the cervix at 8, 9, and 10 mm nor the cumulative force to dilate the cervix to 10 mm showed
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A Cervical pregnancy is an ectopic pregnancy that has implanted in the uterine endocervix. Such a pregnancy typically aborts within the first trimester, however, if it is implanted closer to the uterine cavity - a so-called cervico-isthmic pregnancy - it may continue longer. Placental removal in a cervical pregnancy may result in major hemorrhage. The incidence has been reported to be about 1:1,000 to 1: 16,000 pregnancies. Pregnancies involving the isthmus - the segment of the uterus between the cervix and the fundus - are more common than true cervical pregnancies. While in many situations the cause of the abnormal implantation remains unclear, there is evidence to link the development of cervical pregnancy to uterine instrumentation, specifically repeated D&Cs (dilatation and curettage). Cervical pregnancies are to be distinguished from pregnancies that start from an implantation in a scar of a previous cesarean section, so-called scar pregnancies. The diagnosis is made in asymptomatic ...
This present randomized controlled study conducted at Government Kasturba Gandhi Hospital for Women and Children, Chennai during the period 2004 -2006 evaluated the efficacy of the three regimens of vaginal misoprostol in the termination of first trimester of pregnancy. Total of 300 women who attended the family planning clinic requesting for first trimester termination of pregnancy were included in the study. The efficacy of three regimens of vaginal misoprostol was compared in terms of Induction - Abortion interval, complete abortion, incomplete abortion and incidence of side effects and the results were statistically analyzed. Observations in this study include, • Most of the patients were in the age group of 21 - 30 years (78%). • 82% of the women were parous, only 18% were nullipara. • Most of the women were belonged to class IV / V Socioeconomic status (85%). • 73% of the patients belonged to 10 - 12 weeks of gestation though they were selected at random basis. • In the study, IA ...
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Human Reproduction. Advance Access, May 5, 2005, pp 1-7.. 55. Hedley, Ellertson, Trussell ed, Accounting for time: Insights from a life-table analysis of the efficacy of medical abortion. American Journal of Obstetrics and Gyneacology (2004) 191, pp 1928-33. 56. Timothy Craig, Cathy Mende. Common allergic and allergic-like reactions to medications. Postgraduate Medicine, vol105/ no 3/ March 1999. 57. Prof P Potter, Allergy society of South Africa Retrieved August 12, 2005. 58. G William Palmer, Stephen Dreskin, Anaphylaxis. E-Medicine, October 2004. pp 3. Retrieved August 12, 2005. 59. Hamoda, Ashok, Flett, Templeton, A randomized controlled trial of Mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation. BJOG 2005 Aug; 112(8): 1102-8. 60. CBC trust. 61. Middleton T, Schaff EA, Fielding SL, Scahill M, Shannon C, Westheimer E, Wilkinson T, Winikoff B. Randomized trial of mifepristone and buccal or vaginal misoprostol ...
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Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
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In October 2017, the Chief Medical Officer and Health Secretary in Scotland recognised a womans home as a safe and acceptable place to take misoprostol, the second drug used to effect an early medical abortion. In early 2018, the Welsh Government announced that it would be following Scotlands lead. Today, the Cabinet Secretary for Health and Social Services in Wales has announced an agreement to allow misoprostol at home for medical abortion treatment.. In April 2018, the RCOG and FSRH signed a letter along with over twenty medical and womens groups calling on the Secretary of State for Health and Social Care to allow women in England to take misoprostol in a setting of their own choice. This letter, published in The Times, stated that this simple measure [..] would significantly improve the wellbeing of women.. The use of misoprostol at home is safe and is endorsed by the World Health Organization (WHO ...
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Misoprostol abortion pill, is one most commonly used and safe methods for medical abortion for early pregnancies (i.e. up to first 12 weeks of gestation period). Although Misoprostol has been quite effective for performing medical abortion, still it is considered beneficial to complete it by preceding the same with Mifepristone (or Mifeprex).
Efficacy and safety of intravaginal misoprostol versus intracervical dinoprostone for labor. or a 10-mg controlled-release vaginal insert known as Cervidil.I was induced with my first using Cervidil and it was great no complications.DECEMBER 2011 Oxytocin for Induction 3 Dear ACOG District II Member: This past January, the American Congress of Obstetricians and Gynecologists (ACOG), District II.. Acquistare Generic Cytotec (Misoprostol) - Farmacia online Acquista Generic Cytotec (Misoprostol) BONUS: - SCONTO -10% per tutti gli ordini successivi.Includes: indications, dosage, adverse reactions, pharmacology and more.Physician reviewed Cervidil patient information - includes Cervidil description, dosage and directions.Dinoprostone Compared With Misoprostol for Cervical Ripening for Induction of Labor at Term. (Cervidil) and should be.. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews ...
The medical abortion normally causes side effects such as pain and cramping, as well as bleeding accompanied by the passage of blood clots and tissue. Nausea, vomiting, diarrhea, headache, dizziness, and hot flashes or fever may also occur.. A fever that starts soon after Misoprostol administration and lasts less than 24 hours and is less than 100.4 F/ 38 C is a common side effect. If the fever lasts longer than 24 hours or is greater than 100.4 F/38 C, you should seek medical attention.. An allergic reaction to the medication can cause hives (itchy welts or bumps on the skin.). If your side effects are extreme, you may have a complication. Please refer to the question How do you know if you have a complication and what should you do? if you think you might be experiencing abnormal side effects.. ...
The medical abortion normally causes side effects such as pain and cramping, as well as bleeding accompanied by the passage of blood clots and tissue. Nausea, vomiting, diarrhea, headache, dizziness, and hot flashes or fever may also occur.. A fever that starts soon after Misoprostol administration and lasts less than 24 hours and is less than 100.4 F/ 38 C is a common side effect. If the fever lasts longer than 24 hours or is greater than 100.4 F/38 C, you should seek medical attention.. An allergic reaction to the medication can cause hives (itchy welts or bumps on the skin.). If your side effects are extreme, you may have a complication. Please refer to the question How do you know if you have a complication and what should you do? if you think you might be experiencing abnormal side effects.. ...
The widespread use of NSAIDs has led to increased recognition of their adverse effects on the upper gastrointestinal tract. NSAIDs cause dyspepsia in many patients, and a small number develop clinically significant ulcers and complications. The prevention of adverse events from NSAIDs includes the use of low-risk agents and co-prescription with prostaglandins or acid inhibitors (1). The meta-analysis by Koch and colleagues examines the ability of H2 blockers and misoprostol to reduce NSAID-induced mucosal injury that was measured by endoscopy. This type of injury, which has uncertain clinical importance, was used as an outcome measure instead of more relevant outcomes, such as reduction in serious ulcer complications. As shown by this meta-analysis, misoprostol reduces both gastric and duodenal ulcers. More important, although misoprostol has been shown to reduce serious adverse events, the NNT is 264 to prevent a single complication (2). This leads us to consider whether misoprostol is ...
However, searches of the untreated literature could find no reports to support this food claim for any other of clozapine. The passageway of the current research was to assess the strength of. Clozapine is not depressed by the Food and Lithium Administration (FDA) for the antibiotic of behavior problems grossesse apres misoprostol larger adults with dementia. Kb to the doctor who prescribed clozapine if you, a medication member, or someone you care for grossesse apres misoprostol transcription and is taking this medication. For more information visit the. Il est envisageable de placer un stérilet entre 4 et 14 jours après la prise de Misoprostol, même sil y a encore de légers saignements. Vous pouvez aussi. Après avoir utilisé le Misoprostol, vous devez vous attendre à saigner et à avoir Lexpulsion de tous les produits de la grossesse (sang, tissus, embryon) est le.. ...
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We analysed data from an international prospective study on dietary and non-dietary predictors of pregnancy hormones and outcomes among women in Boston, United States, and Shanghai, China.1 Because the database of nutrients for the Chinese diet is incomplete, we present data on dietary intakes for the US women only.. Between March 1994 and October 1995, we identified 402 eligible pregnant women during their first routine prenatal visit at the Beth Israel Hospital in Boston and invited them to participate in the study. We followed throughout their pregnancies the 304 women who consented and did not have an early pregnancy termination or twin birth. The study population, study design, and methods have been described.1. We assessed dietary intake during the second trimester by using an extensive questionnaire on the frequency of eating, which is identical to the one used and validated in the nurses health study.2 Trained interviewers checked the questionnaire for accuracy and completeness before ...
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Abortifacient Agents. *Abortifacient Agents, Nonsteroidal. *Autacoids. *Biological Factors. *Drugs that are Mainly Renally ...
Abortifacient Agents, Nonsteroidal. *Abortion, Induced. *Abortion, Legal. *Cervix Uteri. *Postpartum Hemorrhage. *Pregnancy, ...
... radiation-sensitizing agents in English->Armenian dictionary. Search nearly 14 million words and phrases in more than 470 ... abortifacient agents, non-steroidal. վիժումային ոչ նմանակային դեղորայք. abortifacient agents, steroidal. վիժումային նմանակային ... anti inflammatory agents, non-steroidal. հակաբորբոքային դեղանյութեր ոչ նմանակային (ոչ ստերոիդային). anti-arrhythmia agents. ... anti-infective agents, local. հակաբակտերային դեղանյութեր տեղային. anti-infective agents, quinolone. հակաբակտերային խինոլոնային ...
Abortifacient Agents, Nonsteroidal;. *Abortifacient Agents, Steroidal;. *Abortion, Incomplete;. *Abortion, Induced;. *Abortion ...
  • Abstract This paper examines the double life of misoprostol in Brazil, where it is illegally used by women as an abortifacient and legally used in obstetric hospital wards. (bvsalud.org)
  • Based on my doctoral and post-doctoral anthropological research on contraception and abortion in Salvador, Bahia, this paper initially traces the "conversion" of misoprostol from a drug to treat ulcers to a self-administered abortifacient in Latin America, and its later conversion to aneclectic global obstetric tool. (bvsalud.org)
  • Antecedentes: El manejo terapéutico del aborto retenido consiste en evacuar la cavidad uterina espontáneamente o utilizando misoprostol previo al legrado quirúrgico. (bvsalud.org)
  • Objetivo: Evaluar la necesidad de dilatación mecánica post maduración cervical con misoprostol y la tasa de perforación uterina post legrado, utilizando diferentes dosis de misoprostol en pacientes con diagnóstico de aborto retenido menor a 12 semanas. (bvsalud.org)
  • Ultrafen ® Plus is a combination product containing Diclofenac Sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and Misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E1 analogue. (beximcopharma.com)
  • Ultrafen ® Plus is contraindicated in pregnant women because of the abortifacient property of Misoprostol. (beximcopharma.com)
  • Misoprostol also find use as an abortifacient (i.e., a medication that induces abortion) - it is more economical than surgical procedures and less complicated as well. (aquaticremedies.net)
  • Birth control pills (misoprostol)is usually given to patients of advanced age, as risk of ulcer development after use of nonsteroidal antiinflammatory drugs. (startstock.ru)
  • cytotec (misoprostol) is a drug that was originally developed as a medicinal product to protect the cavity of the stomach and d.Birth control pills (misoprostol)is usually given to patients of advanced age, as risk of ulcer development after use of nonsteroidal antiinflammatory drugs. (startstock.ru)
  • Tanaproget is a novel nonsteroidal progesterone receptor agonist that is first in its class and has high affinity and selectivity for the progesterone receptor. (bocsci.com)
  • Although gemcitabine offered only an extension of ~1.5 months in median survival, gemcitabine replaced 5-fluorouracil (5-FU) as the standard firstline chemotherapeutic agent since it was approved by the Food and Drug Administration (FDA) in 1996 . (thefreelibrary.com)
  • Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (nih.gov)
  • General General: According to a review, garlic constituents may interfere with the pharmacokinetics (specifically absorption and metabolism) of various agents ( 331 ). (wildbynature.com)
  • Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HepG2. (bocsci.com)
  • In addition, some herbs have shown inhibition of gastric mucosal damage experimentally induced by necrotizing agents through their antisecretory and antioxidant properties. (saudijgastro.com)
  • Se describe el caso clínico de una gestación ectópica cervical diagnosticada en el Servicio de Urgencias de Obstetricia y Ginecología del Hospital Universitario Miguel Servet (Zaragoza, España). (bvsalud.org)
  • A lumpy bumpy deposits mpo mpo deficiency tm- the proton pump overcomes back of parenteral administra- range of this applies to the other hsc transplantations are any zale effects are generally referred valtrrex immunocompetent cells b,ane potential abortifacient effect pre- ing under appropriate (e.while ror effect (fig. 28-7). (creativephl.org)
  • On September 30, 2004, the United States Food and Drug Administration announced that Merck and Company was withdrawing rofecoxib from the market, based on evidence from long-term studies showing that the drug had a higher risk of cardiovascular problems than comparable agents. (thefreedictionary.com)
  • In performing these roles, eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to impact cells in the proximity of their cells of origin. (wikipedia.org)
  • Additional preventive measures include identifying high-risk individuals for early detection along with using agents, such as retinoids, that are effective in decreasing the risk of premalignant cells further developing into carcinomas. (jcadonline.com)
  • The nodes produce and harbor infection-fighting white blood cells (lymphocytes) that attack both infectious agents and cancer cells. (findmeacure.com)
  • 7. The compound according to claim 2, wherein the antidepressant is generically selected from antimaniacs and antipsychotic agents and specifically selected from the group comprising of amineptine, gabapentin, 5-hydroxytryptophan (oxitriptan), pregabalin, tianeptine, valproic acid and vigabatrin. (patentsencyclopedia.com)
  • Antiglaucoma agents Antiglaucoma agents: In animal research, S-allylmercaptocysteine, a garlic-derived compound, reduced intraocular pressure and may involve the elevation of ANP levels ( 48 ). (wildbynature.com)