Chemical substances that interrupt pregnancy after implantation.
A plant species of the genus PINUS that contains isocupressic acid.
Non-steroidal chemical compounds with abortifacient activity.
Steroidal compounds with abortifacient activity.
Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.
Premature expulsion of the FETUS in animals.
Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.
Maternal deaths resulting from complications of pregnancy and childbirth in a given population.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Premature loss of PREGNANCY in which not all the products of CONCEPTION have been expelled.
A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.
Professional nurses who have received postgraduate training in midwifery.
A republic in western Africa, southwest of MAURITANIA and east of MALI. Its capital is Dakar.
Administration of a soluble dosage form by placement under the tongue.
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
A plant genus of the family ACORACEAE, order Arales, subclass Arecidae most notable for Acorus calamus L. root which contains asarone and has been used in TRADITIONAL MEDICINE.
A plant genus in the family MYRTACEAE, order Myrtales, subclass Rosidae. It is best known for allspice from the dried berry of Pimenta diocia.
A plant species in the PIPERACEAE plant family. It is a common spice on foods and is used medicinally to increase gastrointestinal assimilation of other supplements and drugs. Piperine is a key component. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water.
The myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.
A plant family of the order Arales, subclass Arecidae, class Liliopsida (monocot).
A common spice from fruit of PIPER NIGRUM. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water. Piperine is a key component used medicinally to increase gastrointestinal assimilation of other supplements and drugs.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
An enzyme that in the course of pyrimidine biosynthesis, catalyzes the oxidation of dihydro-orotic acid to orotic acid utilizing oxygen as the electron acceptor. This enzyme is a flavoprotein which contains both FLAVIN-ADENINE DINUCLEOTIDE and FLAVIN MONONUCLEOTIDE as well as iron-sulfur centers. EC 1.3.3.1.
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.
An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
Total pharmaceutical services provided to the public through community pharmacies.
Facilities for the preparation and dispensing of drugs.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
The practice of compounding and dispensing medicinal preparations.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Sequential operating programs and data which instruct the functioning of a digital computer.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
An organothiophosphorus cholinesterase inhibitor that is used as an insecticide.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)

Effect of DL111-IT on progesterone biosynthesis and viability of rat luteal cells in vitro. (1/197)

AIM: To study the influence of DL111-IT on progesterone biosynthesis of cultured luteal cells (LC). METHODS: LC viability was assessed with trypan blue dye exclusion and progesterone concentration was measured with radioimmunoassay. RESULTS: DL111-IT decreased the viability of LC after 24-h incubation, its ED50 being 7.7 (95% confidence limits: 7.1-8.5) mg.L-1. DL111-IT inhibited basal secretion of progesterone in a concentration-dependent manner, and 3 mg.L-1 decreased progesterone concentration by 25% vs control. DL111-IT 3 mg.L-1 also inhibited the stimulatory effect of forskolin (cAMP activator) 10 mumol.L-1 and pregnenolone [converted to progesterone by 3 beta-hydroxysteroid dehydrogenase-isomerase complex (3 beta-HSD)] 10 mumol.L-1 on progesterone production in cultured LC, and their inhibitory rates were 43% and 155%, respectively. At the same concentration, DL111-IT did not influence hCG-induced progesterone production. CONCLUSION: DL111-IT inhibited progesterone synthesis by suppressing the conversion of pregnenolone to progesterone (inactivating 3 beta-HSD) and suppressed the activity of cAMP. DL111-IT 6-24 mg.L-1 decreased the viability of LC.  (+info)

The effectiveness of non-surgical management of early interstitial pregnancy: a report of ten cases and review of the literature. (2/197)

OBJECTIVE: To assess the effectiveness of non-surgical management of interstitial pregnancy. DESIGN: A prospective interventional study. SUBJECTS: Eleven women with the ultrasound diagnosis of interstitial ectopic pregnancy. METHODS: Women with suspected early pregnancy complications were examined by transvaginal ultrasound. Those with the diagnosis of interstitial pregnancy were offered non-surgical treatment with methotrexate, which was administered systemically or by local injection. Follow-up with regular measurements of beta-human chorionic gonadotropin and ultrasound scans continued until the pregnancy had resolved completely. RESULTS: Ten women were managed non-surgically, and one woman opted for surgery. Five women received systemic and five local methotrexate. Local therapy was successful in all five cases (100%), whereas four out of five (80%) women receiving systemic methotrexate were cured. Significant side-effects were noted in two women following systemic therapy. In comparison, there were no side-effects in the group of women who received local therapy. There were no significant differences between the two treatment groups in the length of time taken for the pregnancy to resolve. CONCLUSIONS: Non-surgical treatment of interstitial pregnancy with methotrexate appears to be safe and effective. Local administration appears to be more successful and better tolerated by patients and may be used as the first-line therapy.  (+info)

Once-a-month treatment with a combination of mifepristone and the prostaglandin analogue misoprostol. (3/197)

In this two centre study, the efficacy of 200 mg mifepristone orally followed 48 h later by 0.4 mg misoprostol orally for menstrual regulation was investigated. The dose of mifepristone was taken the day before the expected day of menstruation. Each volunteer was planned to participate for up to 6 months. A plasma beta human chorionic gonadotrophin (HCG) was measured on the day of mifepristone intake. The study was disrupted prematurely due to low efficacy. In 125 treatment cycles the overall pregnancy rate was 17.6% (22 pregnancies) and the rate of continuing pregnancies (failure) was 4.0%. Eight women discontinued the study due to bleeding irregularities which were seen in 15 cycles (12%). These effects on bleeding pattern made the timing of treatment day difficult. Late luteal phase treatment with a combination of mifepristone and misoprostol is not adequately effective for menstrual regulation.  (+info)

Angiotensin II interacts with prostaglandin F2alpha and endothelin-1 as a local luteolytic factor in the bovine corpus luteum in vitro. (4/197)

Recent findings suggest that the ovarian renin-angiotensin system may regulate ovarian function through the paracrine/autocrine actions of angiotensin II (Ang II). In this study, we have examined and characterized the local effects of Ang II as a luteolytic factor and its interaction with prostaglandin F2alpha (PGF2alpha) and endothelin-1 (ET-1) in the bovine corpus luteum (CL) of the mid-luteal phase, by using an in vitro microdialysis system (MDS). Ang II was detected in the MDS perfusate (4 pg/ml), and infusion of PGF2alpha (10(-6) M) for 2 h increased the Ang II release by 50-100% during the following experimental period, in addition to its stimulation of ET-1 release. Two 2-h infusions of Ang II (10(-7)-10(-5) M) separated by a 2-h interval induced a dose- and time-dependent decrease of progesterone (P4) release by 41-66%. When the luteal explants were pre-perfused with PGF2alpha (10(-6) M) for 2 h, two consecutive perfusions of Ang II (10(-6) M) at a 2-h interval rapidly reduced the P4 release (by 50%). This reduction occurred 6 h earlier than those of infusions of PGF2alpha or Ang II alone. The simultaneous infusion of either 1) Ang II (10(-6) M) with PGF2alpha (10(-6) M), 2) ET-1 (10(-7) M) with PGF2alpha, or 3) Ang II + ET-1 with PGF2alpha (10(-6) M) for 2 h also induced a rapid and pronounced (60%) decrease in P4 release. Perfusion with the Ang II antagonist blocked the P4-suppressing activity of Ang II alone or PGF2alpha + Ang II infusion. Ang II stimulated the release of ET-1 and oxytocin during infusion but inhibited them after infusion. These results show that Ang II is released in the bovine midcycle CL in vitro, and this peptide, either alone or together with PGF2alpha, can suppress the release of P4. As PGF2alpha directly stimulated Ang II release, Ang II may influence the critical period for starting the cascade of functional luteolysis in vivo and might lead to structural luteolysis with ET-1 as a major vasoconstrictor. The overall results suggest that Ang II may have an important role at luteolysis in the bovine CL.  (+info)

Does an acidic medium enhance the efficacy of vaginal misoprostol for pre-abortion cervical priming? (5/197)

Absorption pharmacokinetics reveal a relationship between plasma concentrations of misoprostol and its therapeutic effect. To achieve a constant plasma profile and optimal efficacy, it is important to develop a medium that ensures complete dissolution of vaginal misoprostol tablets. Vaginal misoprostol is said to liquefy better in an acidic medium; thus, the aim of this study was to determine whether a 200 microg misoprostol tablet dissolved in acetic acid would be more efficacious than 200 microg misoprostol dissolved in water for pre-abortion cervical priming. A total of 120 healthy nulliparous women requesting legal termination of pregnancy between 6-12 weeks gestation were allocated randomly to either of the study groups. Vacuum aspiration was performed 3-4 h after insertion of the misoprostol tablet. Using Hegar's dilator, the degree of cervical dilatation before operation was measured. Of 60 women, 14 (23%) achieved a cervical dilatation of >/=8 mm when the misoprostol dose was dissolved in acetic acid; 12 (20%) achieved a similar cervical dilatation when the dose was dissolved in water. The mean cervical dilatation for the acid and water media used was 6.3 mm and 6.2 mm respectively; these differences were not statistically significant, neither were pre-operative and intra-operative blood losses statistically different between the two groups. Twenty-four (40%) and four (7%) respectively of women in whom a water medium was used experienced vaginal bleeding and abdominal pain; 20 (33%) and 0 women respectively among those in whom an acetic acid medium was used experienced vaginal bleeding and abdominal pain. These differences in side effects were not statistically significant. Our study shows that the use of acetic acid to dissolve vaginal misoprostol does not improve the efficacy in achieving successful cervical dilatation for pre-abortion cervical priming.  (+info)

The use of misoprostol for pre-operative cervical dilatation prior to vacuum aspiration: a randomized trial. (6/197)

Misoprostol is effective for cervical priming prior to vacuum aspiration for first trimester termination of pregnancy. Previous studies showed that the oral route was more acceptable to patients but there were higher incidences of side-effects when compared with the vaginal route. This study is to determine the optimal dosage and route of administration of misoprostol for pre-operative cervical dilatation. A double-blind, randomized trial was undertaken for 225 nulliparous women with 8-12 weeks amenorrhoea. They were randomly assigned to groups given 0 (placebo), 200 or 400 microg oral or vaginal misoprostol 3 h prior to vacuum aspiration. In misoprostol-treated groups the baseline cervical dilatation was significantly increased when compared with the placebo group; the effect was dose-related in the oral but not in the vaginal group. The cumulative force and blood loss was significantly decreased in the misoprostol-treated groups. The incidences of side-effects were more frequent in misoprostol groups but were not related to the route and dosage of medication. The duration of procedure, incidences of post-operative complications, the duration of post-operative bleeding and the interval to the first period were similar in the five treatment groups. We conclude that a 3 h pre-treatment interval is effective for both oral and vaginal routes. When given orally, 400 microg is more effective than 200 microg. The efficacy was otherwise similar when compared with the vaginal route. We recommend 400 microg oral misoprostol 3 h prior to vacuum aspiration for cervical dilatation.  (+info)

Induction of parturition in bitches with minimal side effects by two injections of a low dose of fenprostalene, a prostaglandin F2alpha analogue, and pretreatment with prifinium bromide. (7/197)

An experiment using 16 Beagle bitches (aged 11 months to 6 years and 2 months) in their 56th to 58th day of pregnancy was carried out to investigate the effects of two injections of a low dose of fenprostalene, a long-acting prostaglandin F2alpha analogue, and pretreatment with prifinium bromide, a parasympathetic nerve blocking agent, on the induction of parturition and severity of side effects. The bitches were divided into three treatment groups: one injection of 5 microg/kg of fenprostalene (group I, n=5); one injection of 7.5 mg/head of prifinium bromide followed by one injection of 5 microg/kg of fenprostalene at 5 min after prifinium bromide injection (group II, n=6); and one injection of 7.5 mg/head of prifinium bromide followed by two injections of 2.5 microg/kg of fenprostalene, one injection at 5 min after prifinium bromide injection and the next at 1 hr after the fenprostalene first injection (group III, n=5). Following the injection of fenprostalene, side effects such as salivation, vomiting, colic symptoms, and watery diarrhea occurred most frequently (80-100% of cases) in group I bitches. Apart from colic symptoms, no side effects were observed in group III bitches. Group III bitches also showed the smallest increase in plasma cortisol concentration. No significant difference in the time to initiation of parturition was found between the three groups. The one-week survival rate of newborn puppies was highest in group III. The results showed that pretreatment with prifinium bromide and two injections of 2.5 microg/kg of fenprostalene can alleviate side effects following fenprostalene administration and have no adverse effect on the survival of newborn puppies, indicating that this method is a reliable and safe way of inducing parturition in bitches.  (+info)

A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: a randomized comparative trial. (8/197)

A prospective randomized trial was conducted in 148 women to compare the efficacy of two regimens of vaginal misoprostol for termination of second trimester pregnancy. Women aged 16-40 years requesting termination of second trimester pregnancy were randomized into two groups. Women in group 1 were given vaginal misoprostol 400 microg every 3 h for a maximum of five doses in 24 h. Women in group 2 were given vaginal misoprostol 400 microg every 6 h for a maximum of three doses in 24 h. If women did not abort in 24 h, the same regimen was repeated. The median induction-abortion interval in group 1 (15.2 h) was significantly shorter (P < 0.01) than that in the group 2 (19.0 h). The percentage of women who achieved successful abortion within 48 h in group 1 (90.5%) was also significantly higher (P < 0.02) than that in group 2 (75.7%). The incidence of fever was more common in group 1 (P = 0.01). It is concluded that the regimen of vaginal misoprostol 400 microg every 3 h with maximum of five doses in 24 h was more effective than the regimen of misoprostol every 6 h in termination of second trimester pregnancy.  (+info)

Early pregnancy termination: a comparison between vacuum aspiration and medical abortion using prostaglandin (16,16 dimethyl-trans-delta 2-PGE1 methyl ester) or
The main purpose of our study was to which determine factors, those measured by ultrasound and also demographic and clinical factors (age, number of previous pregnancies, abortions and deliveries) predict outcome of medical treatment for early pregnancy failure. Our hypothesis was that gestational sac volume predicts outcome of medical treatment for early pregnancy failure ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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OBJECTIVE To compare the efficacy of 400 microg of misoprostol with that of 1 mg of gemeprost as cervical priming agents when administered vaginally 3 to 4 hours before first-trimester vacuum aspiration abortion. METHODS In a prospective controlled trial 90 nulliparous women who requested termination of pregnancy before 12 weeks gestation were randomized to receive vaginally either misoprostol or gemeprost for cervical priming. The force to dilate the cervix was measured by the use of a cervical tonometer connected to Hegar dilators from 3 to 10 mm. The main outcome measures were baseline cervical dilation; the peak force to dilate the cervix at 8, 9, and 10 mm; and the cumulative force to dilate the cervix to 10 mm. RESULTS Baseline cervical dilation did not differ significantly between the women who received misoprostol and those who were treated with gemeprost. Neither the peak force required to dilate the cervix at 8, 9, and 10 mm nor the cumulative force to dilate the cervix to 10 mm showed
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A Cervical pregnancy is an ectopic pregnancy that has implanted in the uterine endocervix. Such a pregnancy typically aborts within the first trimester, however, if it is implanted closer to the uterine cavity - a so-called cervico-isthmic pregnancy - it may continue longer. Placental removal in a cervical pregnancy may result in major hemorrhage. The incidence has been reported to be about 1:1,000 to 1: 16,000 pregnancies. Pregnancies involving the isthmus - the segment of the uterus between the cervix and the fundus - are more common than true cervical pregnancies. While in many situations the cause of the abnormal implantation remains unclear, there is evidence to link the development of cervical pregnancy to uterine instrumentation, specifically repeated D&Cs (dilatation and curettage). Cervical pregnancies are to be distinguished from pregnancies that start from an implantation in a scar of a previous cesarean section, so-called scar pregnancies. The diagnosis is made in asymptomatic ...
This present randomized controlled study conducted at Government Kasturba Gandhi Hospital for Women and Children, Chennai during the period 2004 -2006 evaluated the efficacy of the three regimens of vaginal misoprostol in the termination of first trimester of pregnancy. Total of 300 women who attended the family planning clinic requesting for first trimester termination of pregnancy were included in the study. The efficacy of three regimens of vaginal misoprostol was compared in terms of Induction - Abortion interval, complete abortion, incomplete abortion and incidence of side effects and the results were statistically analyzed. Observations in this study include, • Most of the patients were in the age group of 21 - 30 years (78%). • 82% of the women were parous, only 18% were nullipara. • Most of the women were belonged to class IV / V Socioeconomic status (85%). • 73% of the patients belonged to 10 - 12 weeks of gestation though they were selected at random basis. • In the study, IA ...
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Human Reproduction. Advance Access, May 5, 2005, pp 1-7.. 55. Hedley, Ellertson, Trussell ed, Accounting for time: Insights from a life-table analysis of the efficacy of medical abortion. American Journal of Obstetrics and Gyneacology (2004) 191, pp 1928-33. 56. Timothy Craig, Cathy Mende. Common allergic and allergic-like reactions to medications. Postgraduate Medicine, vol105/ no 3/ March 1999. 57. Prof P Potter, Allergy society of South Africa Retrieved August 12, 2005. 58. G William Palmer, Stephen Dreskin, Anaphylaxis. E-Medicine, October 2004. pp 3. Retrieved August 12, 2005. 59. Hamoda, Ashok, Flett, Templeton, A randomized controlled trial of Mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation. BJOG 2005 Aug; 112(8): 1102-8 60. CBC trust. 61. Middleton T, Schaff EA, Fielding SL, Scahill M, Shannon C, Westheimer E, Wilkinson T, Winikoff B. Randomized trial of mifepristone and buccal or vaginal misoprostol for ...
Human Reproduction. Advance Access, May 5, 2005, pp 1-7.. 55. Hedley, Ellertson, Trussell ed, Accounting for time: Insights from a life-table analysis of the efficacy of medical abortion. American Journal of Obstetrics and Gyneacology (2004) 191, pp 1928-33. 56. Timothy Craig, Cathy Mende. Common allergic and allergic-like reactions to medications. Postgraduate Medicine, vol105/ no 3/ March 1999. 57. Prof P Potter, Allergy society of South Africa Retrieved August 12, 2005. 58. G William Palmer, Stephen Dreskin, Anaphylaxis. E-Medicine, October 2004. pp 3. Retrieved August 12, 2005. 59. Hamoda, Ashok, Flett, Templeton, A randomized controlled trial of Mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation. BJOG 2005 Aug; 112(8): 1102-8. 60. CBC trust. 61. Middleton T, Schaff EA, Fielding SL, Scahill M, Shannon C, Westheimer E, Wilkinson T, Winikoff B. Randomized trial of mifepristone and buccal or vaginal misoprostol ...
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Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
TY - JOUR. T1 - Oral mifepristone and buccal misoprostol administered simultaneously for abortion. T2 - a pilot study. AU - Lohr, Patricia A.. AU - Reeves, Matthew F.. AU - Hayes, Jennifer L.. AU - Harwood, Bryna. AU - Creinin, Mitchell D. PY - 2007/9. Y1 - 2007/9. N2 - Background: Simultaneous oral mifepristone and vaginal misoprostol has a 24-h expulsion rate of approximately 90% when used for abortion through 63 days gestation. This pilot study sought to determine if a simultaneous regimen using buccal misoprostol would be similarly effective and merit further investigation. Study design: One hundred twenty women were enrolled into three equal groups by gestational age: ≤49 days (Group 1), 50-56 days (Group 2) and 57-63 days (Group 3). After swallowing 200 mg of mifepristone, subjects received 800 mcg buccal misoprostol. Participants returned in 24±1 h for evaluation of expulsion by ultrasonography. Women with a persistent gestational sac received 800 mcg vaginal misoprostol. Further ...
TY - JOUR. T1 - Economic evaluation of misoprostol in the treatment of early pregnancy failure compared to curettage after an expectant management. AU - Graziosi, G. C M. AU - van der Steeg, J. W.. AU - Reuwer, P. H W. AU - Drogtrop, A. P.. AU - Bruinse, H. W.. AU - Mol, B. W J. PY - 2005/4. Y1 - 2005/4. N2 - Background: The increased pressure on health care expenses implies that physicians should consider economic aspects as part of the clinical decision-making process. Direct and indirect costs of a strategy starting with misoprostol in treatment of early pregnancy failure as compared to curettage is therefore performed. Methods: We performed a cost-minimization analysis alongside a multicentre randomized trial. Clinical data and data on the use of medical resources were obtained from a randomized trial comparing misoprostol and curettage, which had shown that misoprostol reduced the need for curettage in 53%. In a sensitivity analysis the percentage of women who needed curettage after ...
Product Name: Mifepristone and Misoprostol Tablets. Common Name: contraceptive pills. Strength: available in -. Mifepristone IP 200mg & Misoprostol IP 200mcg. Description: Medical Abortion is a form of early abortion caused by the combination of two medications, mifepristone and misoprostol that is an option for women who are 8 weeks pregnant or less. Also known as RU486 or medication abortion.. During the first appointment at the clinic you receive the mifepristone pill to take orally. Then 24 to 72 hours later, in the privacy, take the the second medication, misoprostol. Misoprostol causes contractions resulting in a miscarriage. When used in combination, mifepristone and misoprostol are 95-97% effective within two weeks. Mifepristone and misoprostol are FDA approved.. Indications and Usage: Mifepristone is used in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 70 days or less since your last menstrual period began. Mifepristone is in a ...
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This study sought to assess the feasibility and acceptability of introducing medical abortion up to 63 days LMP in Uzbekistan, with the option of home administration of misoprostol. Findings include a high success rate and high acceptability among participants. In addition, almost all women chose to administer the misoprostol at home.. Access the abstract.. ...
Usually women do not feel anything after taking the mifepristone (the first pill that is swallowed). A few women have reported experiencing some nausea, dizziness, or very light bleeding.. After taking misoprostol, you may initially feel side effects from the misoprostol, including a light fever, chills, diarrhea, and nausea. These are normal side effects and usually pass within a few hours or so of using the misoprostol.. The misoprostol will cause cramping and bleeding as the uterus contracts and pushes out the pregnancy. If a woman uses mifepristone plus misoprostol, the cramps and bleeding usually start within 1-5 hours after using the misoprostol, but some women have cramps sooner and some later; every womans body is different. If a woman is using misoprostol alone, most women will start bleeding within 7 hours after using misoprostol; however it may start several hours sooner or later. It can be different in every case.. Bleeding is usually heavier than a period and often accompanied by ...
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Induced Abortion. The American College of Obstetricians and Gynecologists. 2001.. Pymar HC, Creinin MD (2000). Alternatives to mifepristone regimens for medical abortion. American Journal of Obstetrics and Gynecology, 183 (2): s54-s64.. Paul M, et al. (1999). A Clinicians Guide to Medical and Surgical Abortion. New York: Churchill Livingstone.. Creinin MD, et al. (2001). Medical management of abortion. American Journal of Obstetrics and Gynecology Practice Bulletin, no. 26, pg.1-13.. Goldberg ab, et al. (2001). Misoprostol and pregnancy. New England Journal of Medicine, 344 (1): 3845.. Spitz IM, et al. (1998). Early pregnancy termination with mifepristone and misoprostol in the U.S. New England Journal of Medicine, 338 (18): 1241-1247.. ...
Induced Abortion. The American College of Obstetricians and Gynecologists. 2001.. Pymar HC, Creinin MD (2000). Alternatives to mifepristone regimens for medical abortion. American Journal of Obstetrics and Gynecology, 183 (2): s54-s64.. Paul M, et al. (1999). A Clinicians Guide to Medical and Surgical Abortion. New York: Churchill Livingstone.. Creinin MD, et al. (2001). Medical management of abortion. American Journal of Obstetrics and Gynecology Practice Bulletin, no. 26, pg.1-13.. Goldberg ab, et al. (2001). Misoprostol and pregnancy. New England Journal of Medicine, 344 (1): 3845.. Spitz IM, et al. (1998). Early pregnancy termination with mifepristone and misoprostol in the U.S. New England Journal of Medicine, 338 (18): 1241-1247.. ...
Women do not easily look for a decision as difficult as an abortion. There are many things to be taken into consideration before someone actually opts for an abortion. For termination of pregnancy, it is always advised for a person to decide whether abortion should be carried out through medical abortion or through an invasive process. Pregnancies as long as 10th week can be terminated by the best non-invasive method which is a medical abortion. For medical abortions, doctors recommend women to buy MTP Kit online.. MTP Kit is said to be the best early pregnancy termination abortion pill which helps in safe abortion. The primary abortion medications which are Mifepristone and Misoprostol help in termination of pregnancy in a better way. The kit comprises of 1 tablet of Mifepristone and 4 tablets of Misoprostol which is a complete abortion kit helps in safe abortion. Certain contraceptives fail which leaves the process undone so make sure to opt for a trusted pregnancy termination pills.. It has ...
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|p|A regimen of mifepristone and misoprostol was significantly more effective for termination of pregnancies | or = 56 days than misoprostol alone. The 88% efficacy obtained with vaginal misoprostol alone may be clinically acceptable when mifepristone is not available.|/p|
Buccal use: 24h after using mifepristone women are advised to use misoprostol between the cheek and gums, let it dissolve and swallow the remains 30 minutes later.. Women are advised to use the pills buccally (in the cheek) because the side effects (like nausea, vomiting, diarrhea, abdominal pain) tend to be less intense when compared to using misoprostol under the tongue.. However, there are other ways to use the misoprostol:. Misoprostol is very effective when administered buccally, sublingually (under the tongue) or vaginally (inside the vagina)1 Misoprostol is NOT very effective when swallowed. 26 It is digested in the stomach and does not work very well.. When misoprostol is used buccally, sublingually or vaginally the medicine is directly absorbed into the blood. However, since pills used in the vagina may be found by a doctor, and since under the tongue (sublingual) causes more nausea and stomach problems, the buccal method is most recommended.. ...
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Looking for incomplete abortion? Find out information about incomplete abortion. Expulsion of only part of the product of conception, with some of the membranes or placenta remaining in the uterus Explanation of incomplete abortion
This was the report of a study comparing two induction agents for term rupture of membranes. The authors compared sublingual misoprostol with vaginal prostaglandinE2 [Prostin] in a randomised trial involving 57 patients: (28 women with term SRM in otherwise uncomplicated singleton pregnancies received Prostin, while 29 had Misoprostol 24 -48 hours after the time of ruptured membranes.. Once the patients started contracting, they were transferred to the delivery suite for continuous monitoring and a partographic record of labour was maintained. Spontaneous vaginal delivery was achieved in 64% of the Prostin group and 86% of the misoprostol group. The mean induction of labour to delivery time was 20.71 +/- 11.59 h in the prostin group and 13.96+/-9.90h in the misoprostol group with a p value of 0.021.. Up to 46.4% of women randomised to the Prostin group required a second dose of the drug compared to 20.7% in the Misoprostol group There were two cases of hyper stimulation recorded in the ...
An interstitial pregnancy is a uterine but ectopic pregnancy; the pregnancy is located outside the uterine cavity in that part of the fallopian tube that penetrates the muscular layer of the uterus. The term cornual pregnancy is sometimes used as a synonym, but remains ambiguous as it is also applied to indicate the presence of a pregnancy located within the cavity in one of the two upper horns of a bicornuate uterus. Interstitial pregnancies have a higher mortality than ectopics in general. The part of the Fallopian tube that is located in the uterine wall and connects the remainder of the tube to the endometrial cavity is called its interstitial part, hence the term interstitial pregnancy; it has a length of 1-2 cm and a width of 0.7 cm. Its borders are the opening (ostium) of the tube to the endometrial cavity within the uterus and, laterally, the visible narrow segment of the tube. The area is well supplied by the Sampson artery which is connected to both the uterine and the ovarian ...
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It is very difficult to determine whether an abortion has been successful and complete. The only way to make sure is to have an ultrasound. You could tell the doctor that you think you had a miscarriage. You could also take a pregnancy test after 3 weeks.. Should you still be pregnant, then you can repeat the treatment in a couple of days. Scientific research has prove that it is most effective if the woman puts 4 tablets Misoprostol under the tongue. Do not swallow!! After 3 hours she should put another 4 pills of Misoprostol under the tongue. 3 Hours later she should use 4 pill of Misoprostol under her tongue again for a third time.. On How can I do an abortion, you will find the instructions in full. It might be that Misoprostol will not be effective again; it will induce an abortion only in about 80% of the cases.. You can also do a medical abortion with Mifepriston and Misoprostol, this method is effective in 99% of the cases. For this option, please go to Women on Web, this is an online ...
A randomised comparison of patient satisfaction with vaginal and sublingual misoprostol for induction of labour at term - BJOG: An International Journal of Obstetrics and Gynaecology - Vol. 114, 10 - p.1215-1221
The efficacy of 400 micrograms misoprostol daily in the prevention of NSAID (non-steroidal anti-inflammatory drug)-induced gastric ulcer has been proven. We calculated the cost-effectiveness of a 3-month course of treatment of 200 micrograms twice daily for patients of the sick fund Wiener Gebietskrankenkasse, based on charges of the year 1993. Since efficacy in preventing NSAID-induced gastric ulcers has not yet been proven for any other drug, we compared misoprostol-treated patients with untreated controls. The model was based on the following assumptions: 70% compliance with respect to misoprostol treatment, 5.6% incidence of gastric ulcer in patients protected with misoprostol, 21.7% incidence among unprotected NSAID users, 20% hospitalisation among patients with gastric ulcer. When using Kassenpreis (drug price paid by the sick funds) misoprostol treatment is cost-effective at costs of AS 64,100,--for inpatient care, upwards and at costs of AS 43,361,-upwards when using Apothekeneinstandspreis
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Induced Abortion. The American College of Obstetricians and Gynecologists. 2001.. Pymar HC, Creinin MD (2000). Alternatives to mifepristone regimens for medical abortion. American Journal of Obstetrics and Gynecology, 183 (2): s54-s64.. Paul M, et al. (1999). A Clinicians Guide to Medical and Surgical Abortion. New York: Churchill Livingstone.. Creinin MD, et al. (2001). Medical management of abortion. American Journal of Obstetrics and Gynecology Practice Bulletin, no. 26, pg.1-13.. Goldberg ab, et al. (2001). Misoprostol and pregnancy. New England Journal of Medicine, 344 (1): 3845.. Stewart GK (1998). Intrauterine devices. In RA Hatcher et al., eds., Contraceptive Technology, 17th rev.ed., pp.511-544. New York: Ardent Media.. Spitz IM, et al. (1998). Early pregnancy termination with mifepristone and misoprostol in the U.S. New England Journal of Medicine, 338 (18): 1241-1247.. ...
Thesis, English, Sublingual versus intravaginal misoprostol for treatment of missed abortion a double blind study for Ziena Heba Hamid Morsy
Medical extinction of maternity widely exerts at early stage of 1st trimester of pregnancy including mifepristone in grouping with a prostaglandin analog range to 7 weeks of supposition length. Moreover, the grouping of Mifepristone & misoprostol equally works fabulous & responsive to abandon an early pregnancy. Generally, the path of pregnancy termination includes 7 weeks of incubation; therapeutic extinction using mifepristone-misoprostol calculated wide working than vacuum aspiration. This consequences when the clinically work out fail to engross any wide scrutiny of expressed tissue. One after practice of mifepristone must take misoprostol with the gap of 24-48 hours late than buccal or vaginal misoprostol is prescribed to exercise to get 98% active response of ending early pregnancy. One needs to exercise mifepristone & misoprostol to end early pregnancy not for the late pregnancy. One must maintain the pregnancy of 7 to 8 weeks of duration to include in medical abortion process as moving ...
Results 748 women were randomised to either 600 µg misoprostol (n = 374) or placebo (n = 374). 93% of women were followed up and 80% of drug packets (both used and unused) were retrieved. 56.7% of women took the study medication. Medication was taken before delivery in 2 women (both in the misoprostol group) and no harm was reported. The primary outcome (fall in Hb ,20%) occurred in 7.3% of recruits. There were no significant differences between the groups in the rate of postnatal anaemia or self-reported blood loss. There was significantly more self-reported fever and shivering in the misoprostol group but acceptability of side effects was high.. ...
The United Kingdoms largest independent abortion provider is mounting a High Court challenge to make it possible for women to complete early stage abortions at home.. BPAS, formerly known as the British Pregnancy Advisory Service, is asking the court to rule that the 1967 Abortion Act allows women to take the second dose of tablets for an early medical abortion at home.. The act says that any treatment for the termination of pregnancy has to be carried out at a hospital or clinic. Early medical abortion, available in the first nine weeks of … ...
For detailed instructions how to do an abortion with use of misoprostol alone please go to Women on Waves website. You can also see a map with information about each country, the legality of abortion, availability and the brands of misoprostol.. Get misoprostol only from a pharmacy or a reliable source. Unfortunately there is a lot of scam and fake medicines are sold on the black market. Read the warnings here.. In some countries Safe Abortion Hotlines can give you information over the phone about the use of misoprostol and other safe abortion methods. Click here to see the list of hotlines.. If you need support or information about how to use misoprostol alone, please email [email protected] ...
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Misoprostol is an effective, safe, and acceptable method for treating incomplete abortion. It can be successfully used as first-line treatment by nurse-midwives. Success rates over 90% are consistent with findings from previous studies in which drug administration was controlled solely by physicians …
Department of Obstetrics and Gynaecology of Patan Hospital, women admitted for second trimester termination of pregnancy for fetal congenital anomalies and intrauterine fetal demise were studied using the International Federation of Gynaecology and Obstetrics recommended doses of vaginal misoprostol. For congenital anomalies, 400 mcg 3 hourly to a maximum of 5 doses were used. For fetal demise, gestational age of 13-17 weeks received 200 mcg every 6 hourly to a maximum of 4 doses, and 18-26 weeks dose was adjusted to 100 mcg. Main outcome measures included success rate of abortion within 48 hours, induction to delivery interval and maternal side effects ...
MTP Kit (combination of Mifepristone and Misoprostol tablet) is quite effective in the termination of an early pregnancy of 9 weeks of gestation. MTP Kit encloses two important FDA-approved medicines called Mifepristone and Misoprostol. Abortion kit Mifepristone and Misoprostol online USA fast delivery. Know more from here @ PillsUneed.com
Recent efforts to prevent post-partum haemorrhage (PPH) in low-income countries have focused on providing women with access to oral misoprostol during home birth. The WHO recommends using lay health workers (LHWs) to administer misoprostol in settings where skilled birth attendants are not available. This review synthesizes current knowledge about the barriers and facilitators affecting implementation of advance community distribution of misoprostol to prevent PPH, where misoprostol may be self-administered or administered by an LHW.. We searched for and summarized available empirical evidence, and collected primary data from programme stakeholders about their experiences of programme implementation.. We present key outcomes and features of advanced distribution programmes that are in operation or have been piloted globally. We categorized factors influencing implementation into those that operate at the health system level, factors related to the community and policy context and those factors ...
As ladies, we know pregnancy happens. And, sometimes pregnancies dont go as planned.. Labor can be difficult. Postpartum bleeding can happen: postpartum hemorrhage (PPH) is the number one cause of maternal mortality in many African countries. Also, we can lose the baby through a miscarriage or spontaneous abortion. Or, we may terminate the pregnancy - have an abortion - for many reasons.. Many things can happen when youre pregnant. But, medical advances - especially affordable ones that can be used in low-income settings - havent been common.. Enter misoprostol. Misoprostol was developed in the 1980s as a stomach ulcer drug and was not prescribed for pregnant women because it could cause miscarriage. As medical providers began to understand the effect misoprostol had on the cervix and uterus, they began to use it off label to induce labor, medically manage miscarriages and for medical abortion.. Many African countries are leading the way in registering misprostol officially for obygn and ...
The study will evaluate the safety and efficacy of Mifepristone and Misoprostol Versus Misoprostol Alone in the Medical Management of Missed Miscarriage
Surgical abortions -- which are nearly always 100% effective -- can be performed from the time a pregnancy is confirmed until around the end of the second trimester, but second trimester abortions only account for less than around 10% of all abortions, and it is obviously ideal, for someone who wants to terminate, to do so earlier rather than later, physically and emotionally. What type of surgical abortion -- manual vacuum aspiration (MVA), dilation and curettage (D&C) or, more commonly now, dilation and evacuation (D&E) -- depends on the length of the pregnancy and the specific situation. All are currently legal in the U.S. and Canada.. • Manual and/or vacuum aspiration (MVA) or electric vacuum aspiration (EVA) can be done within the first trimester, up to about 13 weeks of pregnancy. It is what is most often used for abortions now, and manual aspiration can be used as soon as four weeks from the last menstrual period. During an aspiration, an injection first numbs the cervix [22] with a ...
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More scientific information:. Research has shown that for women with pregnancies of 8 weeks or less, Misoprostol works with the same efficacy whether it is taken at 12 hours, 24 hours, 48 hours, or as much as 72 hours after Mifepristone.7 Though we instruct women to take Misoprostol 24 hours after Mifepristone and strongly encourage women to follow all the instructions for proper use, if a woman takes it slightly earlier or later, this does not effect the outcome of the medical abortion. 102 ...
Le misoprostol est plus efficace que la sonde de Foley pour déclencher le travail sur un col non favorable. Le fait que cela augmente lincidence des hypertonies ne semble pas affecter les auteurs.
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Using oral mifepristone followed two days later by misoprostol is better than using the latter alone for the medical management of missed miscarriage, trial results show. In the MifeMiso trial, 711 women with missed miscarriage in the first 14 weeks of pregnancy across 28 UK hospitals were randomised to either a 200mg oral dose of the anti-progesterone, mifepristone, or placebo. Women in both trial arms then had a single 800 microgram dose of a prostaglandin - oral, vaginal or sublingual misoprostol - two days later, the authors reported in the Lancet. Large UK trial favours priming with mifepristone followed by misoprostol for medical management.
A study published in BMC Pregnancy and Childbirth examines efficacy and pregnancy complication rates between Foley catheter and oral misoprostol labor induction.
... abortifacient agents, nonsteroidal MeSH D27.505.696.875.131.200 - abortifacient agents, steroidal MeSH D27.505.696.875.360 - ... abortifacient agents, nonsteroidal MeSH D27.505.954.705.131.200 - abortifacient agents, steroidal MeSH D27.505.954.705.360 - ... uricosuric agents MeSH D27.505.954.705 - reproductive control agents MeSH D27.505.954.705.131 - abortifacient agents MeSH ... photosensitizing agents MeSH D27.505.696.875 - reproductive control agents MeSH D27.505.696.875.131 - abortifacient agents MeSH ...
... is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in ... Likewise, a 2016 study found the use of methotrexate, in combination with anti-TNF agents, has been shown to be effective for ... Colebatch AN, Marks JL, Edwards CJ (November 2011). "Safety of non-steroidal anti-inflammatory drugs, including aspirin and ... Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat ...
Nonsteroidal antiinflammatory drugs (NSAIDs) may decrease the incidence of diarrhea with trilostane. Serious gastrointestinal ... Trilostane has also been used as an abortifacient due to its inhibition of progesterone synthesis. Trilostane is not an ... 1245-. ISBN 978-1-4757-2085-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
... eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to ... Labor induction, abortifacient in early pregnancy Dinoprostone. PGE2. labor induction. Iloprost. PGI2 analog. pulmonary artery ... Inhibition of COX-1 and/or the inducible COX-2 isoforms, is the hallmark of NSAIDs (non-steroidal anti-inflammatory drugs), ... stomach ulcers labor induction, abortifacient Travoprost. PGF2α analog. Glaucoma, ocular hypertension. U46619. Longer lived TX ...
Richardson AR, Maltz FN (January 2012). "Ulipristal acetate: review of the efficacy and safety of a newly approved agent for ... Cramping can be treated with painkillers like non-steroidal anti-inflammatory drugs. Other potential complications include ... ISBN 978-0-19-928564-8. unspecified (2001). "Herbal contraceptives and abortifacients". In Bullough VL (ed.). Encyclopedia of ... Jensen JT (October 2011). "The future of contraception: innovations in contraceptive agents: tomorrow's hormonal contraceptive ...
... (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.[1] It is used to ... Methotrexate is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in ... Colebatch, AN (2011). "Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in ... Recently, use of methotrexate in combination with anti-TNF agents has been shown to be effective for the treatment of ...
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In the search for second generation post-coital pregnancy terminating agents belonging to the class of 2-phenyl-triazole[5,1-a] ... Abortifacient Agents / pharmacology*. Abortifacient Agents, Nonsteroidal / pharmacology*. Administration, Oral. Animals. ... 0/Abortifacient Agents; 0/Abortifacient Agents, Nonsteroidal; 0/Isoquinolines; 0/Triazoles; 75318-62-6/2-(1,1-biphenyl-4-yl)-1 ... The results obtained in the bitch make it confirm its potential use as a new orally active agent for the interruption of ...
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol From MEDLINE®/PubMed®, a database of the U.S. National Library of ... Abortifacient Agents, Nonsteroidal / administration & dosage*, adverse effects. Abortion, Induced. Abortion, Missed. ...
0 (Abortifacient Agents, Nonsteroidal); 0 (Abortifacient Agents, Steroidal); 0E43V0BB57 (Misoprostol); 320T6RNW1F (Mifepristone ...
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Humans , Female , Methotrexate , Abortifacient Agents, Nonsteroidal , Treatment Outcome , Abortifacient Agents, Nonsteroidal/ ... Humans , Abortifacient Agents, Nonsteroidal/therapeutic use , Pregnancy, Ectopic/surgery , Pregnancy, Ectopic/drug therapy , ... Humans , Female , Pregnancy , Adolescent , Adult , Young Adult , Abortifacient Agents, Nonsteroidal , Abortion, Criminal , ... Adult , Female , Humans , Infant, Newborn , Pregnancy , Abortifacient Agents, Nonsteroidal , Fetal Death , Misoprostol , ...
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Abortifacient Agents - administration & dosage , Humans , Abortifacient Agents, Nonsteroidal - adverse effects , Vagina , ... Abortifacient Agents, Nonsteroidal - administration & dosage , Prostaglandins E, Synthetic - adverse effects , Adult , Female ... anti-inflammatory agents, non-steroidal - adverse effects (59) 59 Filter by. Remove filter. phosphodiesterase inhibitors - ... 11-Deoxy-16-phenoxy-17,18,19,20-tetranor-prostaglandin E is a highly potent and selective anti-ulcer agent. Analogues of this ...
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Abortifacient Agents, Non-Steroidal (1975-1991). Alprostadil/analogs & derivatives (1975-1991). Anti-Ulcer Agents (1977-1991). ... It is an effective anti-ulcer agent and also has oxytocic properties. ... It is an effective anti-ulcer agent and also has oxytocic properties.. ... Abortifacient Agents, Nonsteroidal. Anti-Ulcer Agents. Oxytocics. Registry Number:. 0E43V0BB57 CAS Type 1 Name:. Prost-13-en-1- ...
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  • Abstract This paper examines the double life of misoprostol in Brazil, where it is illegally used by women as an abortifacient and legally used in obstetric hospital wards. (bvsalud.org)
  • Based on my doctoral and post-doctoral anthropological research on contraception and abortion in Salvador, Bahia, this paper initially traces the "conversion" of misoprostol from a drug to treat ulcers to a self-administered abortifacient in Latin America, and its later conversion to aneclectic global obstetric tool. (bvsalud.org)
  • The use of misoprostol as an abortifacient agent is considered to be safe since it rarely causes serious side effects. (bvsalud.org)
  • Ultrafen ® Plus is a combination product containing Diclofenac Sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and Misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E1 analogue. (beximcopharma.com)
  • Ultrafen ® Plus is contraindicated in pregnant women because of the abortifacient property of Misoprostol. (beximcopharma.com)
  • Drug interaction studies between misoprostol and several nonsteroidal anti-inflammatory drugs showed no effect on the kinetics of ibuprofen or diclofenac, and a 20% decrease in aspirin AUC, not thought to be clinically significant. (nih.gov)
  • Misoprostol also find use as an abortifacient (i.e., a medication that induces abortion) - it is more economical than surgical procedures and less complicated as well. (aquaticremedies.net)
  • Birth control pills (misoprostol)is usually given to patients of advanced age, as risk of ulcer development after use of nonsteroidal antiinflammatory drugs. (startstock.ru)
  • cytotec (misoprostol) is a drug that was originally developed as a medicinal product to protect the cavity of the stomach and d.Birth control pills (misoprostol)is usually given to patients of advanced age, as risk of ulcer development after use of nonsteroidal antiinflammatory drugs. (startstock.ru)
  • It is usually used in patients who have had an insufficient therapeutic response to, or are intolerant to the first-line therapy including full dose non-steroidal anti-inflammatory agents ( NSAIDs ). (drugspi.org)
  • A large proportion of the population all over the world consumes acetylsalicylic acid (ASA: aspirin) or other nonsteroidal, antiinflammatory drugs (NSAIDs). (saudijgastro.com)
  • Use in Special Conditions Abortifacients, Prostaglandins, Tocolytics, and Oxytocics GENERIC/TRADE NAME INDICATIONS FOR USE ROUTES AND DOSAGE RANGES Hematopoietic Agents and maintain blood levels and gradually increase to 6 times daily based on the organs as early as possible. (udisco.com)
  • General General: According to a review, garlic constituents may interfere with the pharmacokinetics (specifically absorption and metabolism) of various agents ( 331 ). (wildbynature.com)
  • 2-(1,1'-Biphenyl-4-yl)- 1,2,4-triazole[5,1-a] isoquinoline (L 14105), a potential orally active contragestational agent for the bitch: studies in the rat, hamster and dog. (biomedsearch.com)
  • The results obtained in the bitch make it confirm its potential use as a new orally active agent for the interruption of unwanted pregnancies. (biomedsearch.com)
  • CP-8668 is an orally active nonsteroidal progesterone receptor modulator with no significant affinity for human glucocorticoid receptor or human estrogen recept. (bocsci.com)
  • Tanaproget is a novel nonsteroidal progesterone receptor agonist that is first in its class and has high affinity and selectivity for the progesterone receptor. (bocsci.com)
  • Some anticancer agents such as methotrexate and trimetrexate are active against malaria. (isharonline.org)
  • Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin's lymphomas. (drugspi.org)
  • Methotrexate is now considered the first-line Disease-modifying antirheumatic drugs ( DMARD ) agent for most patients with Rheumatoid Arthritis. (drugspi.org)
  • Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. (wikipedia.org)
  • Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents. (wikipedia.org)
  • Likewise, a 2016 study found the use of methotrexate, in combination with anti-TNF agents, has been shown to be effective for the treatment of ulcerative colitis. (wikipedia.org)
  • It then shows how, while reducing maternal mortality, its use as an illegal abortifacient has reinforced the double reproductive citizenship regime existing in countries with restrictive abortion laws and poor post-abortion care services, where poor women using it illegally are stigmatised, discriminated against and exposed to potentially severe health risks. (bvsalud.org)
  • Non-steroidal chemical compounds with abortifacient activity. (nih.gov)
  • Steroidal compounds with abortifacient activity. (nih.gov)
  • Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (nih.gov)
  • In this opinion article, we examine how the toxicity of anticancer agents is just a matter of dose or 'only dose makes the poison', as coined in Paracelsus' law. (isharonline.org)
  • It is necessary therapeutic agents for nervous system disorders with reduce toxicity and side effects and with safety and acceptability. (thefreelibrary.com)
  • Abortifacient - contains the chemical khellin, which can cause uterine contractions and trigger a miscarriage in pregnant women. (holistichealthliving.com)
  • 1] All induction agents cause uterine contractions this can affect the blood supply to the fetus, especially if contractions become very frequent. (3dchem.com)
  • Although gemcitabine offered only an extension of ~1.5 months in median survival, gemcitabine replaced 5-fluorouracil (5-FU) as the standard firstline chemotherapeutic agent since it was approved by the Food and Drug Administration (FDA) in 1996 [7]. (thefreelibrary.com)
  • In addition, some herbs have shown inhibition of gastric mucosal damage experimentally induced by necrotizing agents through their antisecretory and antioxidant properties. (saudijgastro.com)
  • The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. (patentsencyclopedia.com)
  • It is an effective anti-ulcer agent and also has oxytocic properties. (bvsalud.org)
  • A pesticide or chemical agent that kills mites and ticks. (nih.gov)
  • Induction agents therefore need to be used with great care and with close fetal monitoring. (3dchem.com)
  • Clobetasol propionate (unless combined with an antibacterial agent) should not be used on any infected areas of skin. (transparencyshipping.com)
  • Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HepG2. (bocsci.com)
  • Eicosanoids may also act as endocrine agents to control the function of distant cells. (wikipedia.org)
  • Se describe el caso clínico de una gestación ectópica cervical diagnosticada en el Servicio de Urgencias de Obstetricia y Ginecología del Hospital Universitario Miguel Servet (Zaragoza, España). (bvsalud.org)
  • 351 ). In theory, the risk of bleeding may be increased by concomitant use of garlic and agents with anticoagulant or antiplatelet effects. (wildbynature.com)
  • concomitant use with other topical agents not studied. (drugs.com)
  • On September 30, 2004, the United States Food and Drug Administration announced that Merck and Company was withdrawing rofecoxib from the market, based on evidence from long-term studies showing that the drug had a higher risk of cardiovascular problems than comparable agents. (thefreedictionary.com)
  • In non-clinical studies in rats and rabbits, exemestane was embryotoxic, fetotoxic, and abortifacient. (eurasiapharmaceuticals.com)
  • Additional preventive measures include identifying high-risk individuals for early detection along with using agents, such as retinoids, that are effective in decreasing the risk of premalignant cells further developing into carcinomas. (jcadonline.com)
  • Newer agents achieving this goal include perillyl alcohol, T4 endonuclease 5, DL-a-tocopherol, and a-difluoromethylornithine. (jcadonline.com)
  • Betaseron (interferon beta-1b) is an immunological agent made from human proteins used to treat relapsing multiple sclerosis (MS). Betaseron will not cure MS, it will only decrease the frequency of relapse symptoms. (rxlist.com)