ABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Blood Grouping and Crossmatching: Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.MNSs Blood-Group System: A system of universal human blood group isoantigens with many associated subgroups. The M and N traits are codominant and the S and s traits are probably very closely linked alleles, including the U antigen. This system is most frequently used in paternity studies.Kell Blood-Group System: Multiple erythrocytic antigens that comprise at least three pairs of alternates and amorphs, determined by one complex gene or possibly several genes at closely linked loci. The system is important in transfusion reactions. Its expression involves the X-chromosome.Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Lewis Blood-Group System: A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.P Blood-Group System: A blood group related to the ABO, Lewis and I systems. At least five different erythrocyte antigens are possible, some very rare, others almost universal. Multiple alleles are involved in this blood group.Glycophorin: The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.Duffy Blood-Group System: A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.Erythroblastosis, Fetal: A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.Isoantibodies: Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Placenta Diseases: Pathological processes or abnormal functions of the PLACENTA.Trichophytin: Antigens from the genus TRICHOPHYTON. Trichophytin has been used in studies of immunological responses to these dermatophytes.Forssman Antigen: A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.Word Association Tests: Lists of words to which individuals are asked to respond ascertaining the conceptual meaning held by the individual.ArchivesResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Research Support, Non-U.S. Gov'tResearch Support, U.S. GovernmentResearch Support, American Recovery and Reinvestment ActResearch Support, N.I.H., ExtramuralPolysaccharidesGlycosyltransferases: Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Indians, South American: Individual members of South American ethnic groups with historic ancestral origins in Asia.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Siberia: A region, north-central Asia, largely in Russia. It extends from the Ural Mountains to the Pacific Ocean and from the Arctic Ocean to central Kazakhstan and the borders of China and Mongolia.South DakotaSouth AmericaGenetic Variation: Genotypic differences observed among individuals in a population.Indians, Central American: Individual members of Central American ethnic groups with ancient historic ancestral origins in Asia. Mexican Indians are not included.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Dyspepsia: Impaired digestion, especially after eating.

Infantile cystinosis in France: genetics, incidence, geographic distribution. (1/1160)

A national distribution of 66 French patients, from 49 sibships, has been studied. Segregation analysis, using the maximum likelihood method, was found to agree with the theoretical values expected in recessive autosomal inheritance. The birthplaces of these patients show an unequal geographic distribution of cystinosis, the incidence being higher in Western France. Compared with the total number of live births during the period 1959 to 1972, the minimum incidence of the condition in the province of Brittany is 1 per 25 909, and the gene frequency 0.0062. In the rest of France, the minimum incidence is 1 per 326,440 and the gene frequency 0.0018. Application of Dahlberg's formula gives a similar result. The mean inbreeding coefficient is 530 X 10(-5), a figure 23 times higher than the mean coefficient of France. An indirect test of inbreeding, the distance between parental birthplaces, was studied, first using the French administrative boundaries, second by using kilometers. This distance was constantly smaller for the parents of patients than for the parents of controls. Analysis of two erythrocyte polymorphisms (ABO and Rh) showed a large excess of group A patients when compared with overall French data. These findings are difficult to interpret on genetic grounds. The genetic reasons for the unequal geographic distribution of cystinosis in France are discussed.  (+info)

Acquisition of human blood group antigens by Schistosoma mansoni. (2/1160)

Juvenile forms of Schistosoma mansoni (schistosomula) have been cultured in human blood of various specificities and tested for the presence of blood group substances on their surfaces. The tests employed were survival following transfer into rhesus monkeys immunized against human blood substances, mixed agglutination reactions, and immunofluorescence. A, B, H AND Lewisb+ antigens were expressed at the surface when the parasites were cultured in blood of appropriate specificities. Rhesus, M N S, AND Duffy antigens could not be detected on the parasite surface following culture. The evidence suggests that the expressed blood group antigens are of host origin and are acquired by the parasite during culture, probably in the form of glycolipids or megaloglycolipids. It is likely that these substances are also acquired by parasites in the bloodstream of man. They may serve to mask surface parasite antigens, and so enable schistosomes to evade parasite-specific humoral or cellular immune responses.  (+info)

H (0) blood group determinant is present on soluble human L-selectin expressed in BHK-cells. (3/1160)

In the present study we show that the H (0) blood group determinant Fuc alpha1-2Gal beta1-4GlcNAc beta1-R is present on N-linked glycans of soluble human L-selectin recombinantly expressed in baby hamster kidney (BHK) cells. The glycans were isolated using complementary HPLC techniques and characterized by a combination of exoglycosidase digestion and mass spectrometry. The linkage of the fucose residues was determined by incubation of the glycans with specific fucosidases. The H blood determinant Fuc alpha1-2Gal beta1-4GlcNAc beta1 was detected for bi-, 2,4 branched tri- and tetraantennary structures. To our knowledge, the proposed oligosaccharide structures represent a new glycosylation motif for recombinant glycoproteins expressed on BHK cells.  (+info)

Poly-N-acetyllactosamine synthesis in branched N-glycans is controlled by complemental branch specificity of I-extension enzyme and beta1,4-galactosyltransferase I. (4/1160)

Poly-N-acetyllactosamine is a unique carbohydrate that can carry various functional oligosaccharides, such as sialyl Lewis X. It has been shown that the amount of poly-N-acetyllactosamine is increased in N-glycans, when they contain Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->4GlcNAcbeta1 -->2)Manalpha1-->6 branched structure. To determine how this increased synthesis of poly-N-acetyllactosamines takes place, the branched acceptor was incubated with a mixture of i-extension enzyme (iGnT) and beta1, 4galactosyltransferase I (beta4Gal-TI). First, N-acetyllactosamine repeats were more readily added to the branched acceptor than the summation of poly-N-acetyllactosamines formed individually on each unbranched acceptor. Surprisingly, poly-N-acetyllactosamine was more efficiently formed on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain than in Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R, due to preferential action of iGnT on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain. On the other hand, galactosylation was much more efficient on beta1,6-linked GlcNAc than beta1,2-linked GlcNAc, preferentially forming Galbeta1-->4GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalph a1-->6Manbeta -->R. Starting with this preformed acceptor, N-acetyllactosamine repeats were added almost equally to Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R and Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chains. Taken together, these results indicate that the complemental branch specificity of iGnT and beta4Gal-TI leads to efficient and equal addition of N-acetyllactosamine repeats on both side chains of GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalpha1-->6Manbet a-->R structure, which is consistent with the structures found in nature. The results also suggest that the addition of Galbeta1-->4GlcNAcbeta1-->6 side chain on Galbeta1-->4GlcNAcbeta1-->2Man-->R side chain converts the acceptor to one that is much more favorable for iGnT and beta4Gal-TI.  (+info)

A predominantly hydrophobic recognition of H-antigenic sugars by winged bean acidic lectin: a thermodynamic study. (5/1160)

The thermodynamics of binding of winged bean (Psophocarpus tetragonolobus) acidic agglutinin to the H-antigenic oligosaccharide (Fucalpha1-2Galbeta1-4GlcNAc-oMe) and its deoxy and methoxy congeners were determined by isothermal titration calorimetry. We report a relatively hydrophobically driven binding of winged bean acidic agglutinin to the congeners of the above sugar. This conclusion is arrived, from the binding parameters of the fucosyl congeners, the nature of the enthalpy-entropy compensation plots and the temperature dependence of binding enthalpies of some of the congeners. Thus, the binding site of winged bean acidic agglutinin must be quite extended to accommodate the trisaccharide, with non-polar loci that recognize the fucosyl moiety of the H-antigenic determinant.  (+info)

Normal human serum contains natural antibodies reactive with autologous ABO blood group antigens. (6/1160)

It is widely accepted that the serum of healthy individuals contains natural antibodies only against those blood group A or B antigens that are not expressed on the individual's red blood cells. The mechanisms involved in tolerance to autologous blood group antigens remain unclear. In the present study, we show that IgM and IgG antibodies reactive with autologous blood group antigens are present in the immunoglobulin fraction of normal human serum. Natural IgG anti-A antibodies purified by affinity chromatography from IgG of individuals of blood group A exhibited an affinity for A trisaccharide antigen in the micromolar range and agglutinated A red cells at sixfold higher concentrations than those required for agglutination with affinity-purified anti-A IgG of individuals of blood group B. Whereas autoantibodies reactive with self A and B antigens are readily detected in purified IgG and IgM fractions, their expression is restricted in whole serum as a result of complementary interactions between variable regions of antibodies. These observations suggest that tolerance to autologous ABO blood group antigens is dependent on peripheral control of antibody autoreactivity.  (+info)

Purification and characterization of an anti-(A+B) specific lectin from the mushroom Hygrophorus hypothejus. (7/1160)

A lectin (HHL) was isolated from the fruiting body of the mushroom Hygrophorus hypothejus by a combination of affinity chromatography on stromas of group B erythrocytes embedded in polyacrylamide gel, and DEAE-trisacryl and gel filtration chromatography. Its molecular mass, as determined by gel filtration, is estimated to be 68000 kDa and its structure is tetrameric with four identical subunits assembled with non-covalent bonds. HHL agglutinates specifically A and B blood group erythrocytes and in hemagglutination inhibition assays, exhibits sugar-binding specificity toward lactose, the anomeric alpha form being more effective than the beta form.  (+info)

Alteration of sialyl Lewis epitope expression in pterygium. (8/1160)

PURPOSE: Mucin-related antigens are abundantly expressed by the cells of the normal human conjunctiva. The pattern of these antigens in pterygium, and especially the role of Galbeta1-3GlcNAc alpha2,3-sialyltransferase (ST3Gal III), sialyltransferase necessary to build the sialyl-Le(a) (Lewis(a)) antigen, were studied. METHODS: Immunoperoxidase staining was performed on 28 pterygia using different monoclonal antibodies: anti-M1 (against the peptidic core of gastric mucins encoded by MUC 5AC gene), anti-Le(a)(7LE), anti-sialyl Le(a)(NS 19-9), and anti-Le(b)(2-25LE). A serologic Lewis determination was done in 18 patients. ST3Gal III sialyltransferase expression was also studied in 10 healthy conjunctiva and 10 pterygia by reverse transcriptase-polymerase chain reaction (RT-PCR). Glyceraldehyde-3-phosphate-dehydrogenase was used as an endogenous internal control. RESULTS: First, Le(a), sialyl Le(a), and Le(b) immunoreactivities either decreased or were no longer detectable in pterygium goblet cells as opposed to normal conjunctiva. Second, unlike in pterygium, the Lewis immunoreactivity, which is mainly located in the surface epithelial cells in the normal conjunctiva, was occasionally restricted to the epithelial cells of the deep layers. However, M1 mucins did show an identical pattern expression in a normal conjunctiva and pterygium. ST3Gal III expression was significantly lower in pterygium (0.20+/-0.02 AU [arbitrary units]) than in normal conjunctiva (0.95+/-0.12 AU). CONCLUSIONS: ST3Gal III gene is less expressed in pterygium than in normal conjunctiva. This observation could explain the decrease of sialyl Le(a) expression observed in pterygium by immunohistology.  (+info)

... definition. Explain ABO blood group system. What is ABO blood group system? ABO blood group system meaning. ABO blood group system sense. ABO blood group system FAQ. ABO blood group system synonyms.
Synonyms for ABO blood group system in Free Thesaurus. Antonyms for ABO blood group system. 2 synonyms for ABO blood group system: ABO group, ABO system. What are synonyms for ABO blood group system?
This site allows the access to the slide presentation Dr. Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The title of his talk was What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, Cell/Tissue/Organ Transplantation to Crime Scene Investigation, and From Humans to Animals. All the slides are listed as figures in the jpg format.
ABO blood group system: ABO blood group system, classification of human blood as determined by the presence or absence of A and B antigens on red blood cells.
This site allows the access to the slide presentation Dr. Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The title of his talk was What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, Cell/Tissue/Organ Transplantation to Crime Scene Investigation, and From Humans to Animals. All the slides are listed as figures in the jpg format.
In the 2 large, prospective cohorts of the NHS and HPFS, we observed a significantly elevated risk of incident CHD for participants with blood group A or B or AB, compared with those with blood group O. The highest risk was observed for blood group AB, followed by blood groups B and A. The association between ABO blood group and CHD risk was not significantly modified by other known risk factors for CHD, including age, sex, alcohol consumption, smoking, physical activity, or diabetes mellitus history. In total, 6.27% of CHD cases were attributable to a non-O blood group (A, B, or AB blood types). A meta-analysis of 6 prospective studies indicated that non-O blood group was associated with an 11% increased risk of CHD compared with O blood group.. Associations between ABO blood groups and CHD have been investigated for several decades. However, the results have been conflicting, especially for the prospective cohort studies. Recently a meta-analysis reported that individuals with non-O blood ...
Background Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and the risk of skin cancer. Methodology/Principal Findings Using two large cohorts in the US, we examined ABO blood type and incidence of skin cancer, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). We followed up study participants (70,650 female nurses and 24,820 male health professionals) on their diagnosis of incident skin cancer from cohort baseline (1976 in women and 1986 in men) until 2006. Study participants reported their blood type in 1996 in both cohorts. During the follow-up, 685 participants developed melanoma, 1,533 developed SCC and 19,860 developed BCC. We used Cox proportional hazards models to calculate the hazard ratios (HR) and 95% confidence intervals (CI) of each type of skin cancer. We observed that non-O blood group (A, AB, and B
The ABO blood group system is the best known blood typing system, determining blood group type as A, B, AB, or O, and thereby of importance for blood donors and recipients. Wikipedia Three common alleles (A, B and O) of the ABO gene yield the six common combinations that a person can have, each of them resulting in a particular ABO blood type (as determined serologically): ...
Helicobacter pylori infection is a high prevalence infection worldwide, and it is more common in developing countries than developed ones (Magalhães and Luzza, 2006). It is a major risk factor for chronic gastritis, peptic ulcer and gastric cancer (Fock and Ang, 2010). The ABO blood group system is the most important in human blood transfusion. The blood group antigens present on RBC are permanent, fixed and lifelong biological markers of any individual, they are almost as individual as fingerprints (Ravn and Dabelstein, 2000). The distribution of the ABO blood groups varies in populations throughout the world (Garratty et al., 2004). In addition to clinical significance for transfusion and transplantation, it is becoming increasingly apparent that ABO antigens are of biological significance and may be associated with predisposition to, or protection from many diseases (Reid and Bird, 1990).. Many authors reported an association between blood group O and H. pylori infection (Kanbay, et al., ...
In the process of ABO-incompatible (ABOi) organ transplantation, removal of anti-A and/or B antibodies from blood plasma is a promising method to overcome hyperacute rejection and allograft loss caused by the immune response between anti-A and/or B antibodies and the A and/or B antigens in the recipient. Although there are commercial columns to do this work, the application is still limited because of the high production cost. In this study, the PglB glycosylation pathway from Campylobacter jejuni was exploited to produce glycoprotein conjugated with Escherichia coli O86:B7 O-antigen, which bears the blood group B antigen epitope to absorb blood group B antibody in blood. The titers of blood group B antibody were reduced to a safe level without changing the clotting function of plasma after glycoprotein absorption of B antibodies in the plasma. We developed a feasible strategy for the specific adsorption/removal of blood group antibodies. This method will be useful in ABOi organ transplantation and
Background: Non-O blood type is associated with higher procoagulant proteins and potentially stroke. Prior studies may overestimate the association due to lack of control for race and stroke risk factors as there are known racial differences in blood type, conventional stroke risk factors, and stroke risk.. Methods: REGARDS recruited 30,239 participants in their homes between 2003-07 from the continental US; 55% were female, 41% were black, and 56% lived in the southeast (by design). Using a case-cohort design, 553 participants with incident stroke and 991 participants without baseline stroke were genotyped to determine blood type. Cox proportional hazard models adjusting for race and Framingham or ARIC stroke risk factors were used to determine the association of blood type with incident stroke.. Results: Blacks had a higher frequency of blood type B (17% vs. 10%) and AB (5% vs. 2%) and a lower frequency of blood type O (31% vs. 42%) than whites (p ,0.001) (Table). Except for diabetes (OR 4.1 ...
ABO blood group phenotype is determined by the expression of specific antigens on red blood cells, endothelial cells, platelets, and many other cells and tissues. The presence of A or B antigen results in the expression of A, B, or AB phenotype, whereas the lack of both A and B antigen results in the expression of the O phenotype. These ABH antigens comprise complex terminal carbohydrate molecules on glycoproteins and glycolipids, generated by the addition of N-acetylgalactosamine (A antigen) or d-galactose (B antigen) to existing N-glycan and O-glycan structures through the action of the ABO glycosyltransferases.7 The A and B alleles of the ABO locus encode A and B glycosyltransferases, which in turn catalyze the transfer of the different carbohydrates onto a common core H antigen, to form an A or B antigen. However, type O individuals only express H antigen because the O isoform of ABO lacks glycosyltransferase activity.8. In the past, studies have associated ABO blood groups with CVD, whereby ...
It is well known that ABO blood group system incompatible kidney transplantation (ABOi-KT) is an effective strategy for end-stage renal disease. The main barrier for ABOi-KT is how to keep host B cell activation and blood group antibody titer in low levels. Moreover, the mechanism of B cell activation induced by blood group antigen was unclear in ABOi-KT. In this study, HK2 cells were identified to express blood group B antigen when cocultured with lymphocytes of blood group A. Optical microscope observation demonstrated that HK2 cells in coculture group gradually decreased. Furthermore, flow cytometer assay identified that T cell phenotypes (CD3+, CD3+CD4+ and CD3+CD8+) had no significant change and B cell phenotypes (CD19+ and CD138+) were all significantly enhanced (3.07 and 3.02 folds) at day 4. In addition, immunoturbidimetry analysis demonstrated that blood group B antibody was significantly increased to 2.35 fold at day 4, IgG was significantly increased to 3.60 and 2.81 folds at days 4 and 8
This study investigated the relationship between ABO blood groups and Rh antigens and rates of CRC, which involves numerous etiological factors. Our results show that the prevalence of blood groups A and B, as well as Rh antigen positivity were significantly higher among CRC patients. Despite being an archive study, it was of a retrospective design, which is a drawback in terms of the strength of the evidence. ABO blood group antigens were discovered by Karl Landsteiner in 1901 and Rh antigens by Huang et al.2 in 1940. The ABO blood group antigens are encoded on chromosome 9q34. Although these antigens are biochemical components of the erythrocyte membrane, they have also been identified in epithelial cells of the gastrointestinal mucosa.6 There is an intriguing hypothesis regarding the pathophysiological link between ABO blood groups and malignancy. Dysregulation of the enzymatic activities of glycosyltransferase A and glycosyltransferase B, which are responsible for cell membrane-mediated ...
Synonyms for group AB in Free Thesaurus. Antonyms for group AB. 2 synonyms for group AB: type AB, AB. What are synonyms for group AB?
|p|Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of
Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization Qing Li,1,* Tao Wu,1,* Xiao-An Ma,2,* Li Jing,1 Li-Li Han,3 Hui Guo1 1Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of General Surgery, Xi’an Central Hospital, Xi’an, Shaanxi, People’s Republic of China; 3Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China *These authors contributed equally to this work Background: The association of ABO blood group with prognosis of several malignancies has been established. However, its role in hepatocellular carcinoma (HCC) remains unclear.Patients and methods: In this study, we investigated the prognostic role of ABO blood group in unresectable HCC patients receiving transarterial chemoembolization (TACE) as
Genetic variations in ABO define the ABO blood group system [MIM:616093]. The ABO blood group system is the most important blood group system in blood transfusion. The sequence shown here is that of the A transferase. The B form differs by a few residues substitution. Residues 266 and 268 are important for specificity. The reference genome assembly (GRCh38/hg38) describes a non-functional O-type ABO allele. The O-type ABO allele results in a guanine deletion (NM_020469.2: c.286delG). This deletion induces a frameshift and creates a premature stop codon resulting in a truncated (117 amino acids) protein deprived of any glycosyltransferase activity (PubMed:2333095 ...
Humans owe a lot to the Rhesus macaque.. This little monkey has provided insights into space travel, cloning and human behaviour. But perhaps most importantly it first alerted scientists to the existence of the famous Rh factor in human blood, a molecule that is either present (Rh+) or absent (Rh-) on our red blood cells, says Dr Bruce Rideout from San Diego Zoos Institute for Conservation Research.. The Rh stands for the rhesus monkey because researchers recognised that this human blood antigen was similar to a rhesus monkey blood antigen. Blood types have only been studied in a handful of primate species, but Rideout says Old World monkeys and apes have been shown to have blood types comparable, although not identical, to the human ABO blood group system.. According to the Australian Red Cross there are more than 270 human blood antigens, belonging to over 30 blood group systems. The two major blood group systems used in transfusions are the Rhesus factor and the ABO blood group ...
Anti-Blood Group A, B and H Antigens antibody [HE-10] (ab2523) has been cited in 2 publications. Find out more about the references
Anti-Blood Group Lewis b antibody [2-25LE] (ab3968) has been cited in 13 publications. References for Human in Flow Cyt, IHC-P, WB
The impact of ABO incompatibility on hematopoietic stem cell transplantation (HSCT) outcome is controversial. As ABH substances are expressed on tissues and secreted in body fluids, they could drive an immune response in minor ABO-incompatible HSCT. The aim of the study was to investigate the prognostic role of the recipients ABH secretor status.; Patients who underwent minor ABO-incompatible HSCT were included. Secretor status was determined either serologically or by molecular genetics.; Between March 1996 and June 2012, a total of 176 patients received minor ABO-incompatible HSCT and 150 (85%) were secretors. Incidence and severity of acute graft-versus-host disease (GVHD) and chronic GVHD did not differ between secretors and nonsecretors (cumulative incidences ± standard errors: acute GVHD on Day 100, 41 ± 11 and 46 ± 5%, p = 0.59; chronic GVHD at 2 years, 52 ± 13 and 56 ± 5%, p = 0.62, for secretors and nonsecretors, respectively). Additionally, nonrelapse mortality (NRM) and overall ...
The relationship of the ABO blood groups to various diseases has received increasing attention of late. Thus, Aird et al.1 report that "the frequency of blood group A is greater and the frequency of blood group O less in patients suffering from cancer of the stomach than in the general population of the locality in which they live." Blood group O has been reported to be strikingly high, and the other three blood groups increasingly low, in patients suffering from peptic ulcer.2 Studies have revealed an inverse relationship between the frequencies of blood groups O and A in patients with ...
Background ABO blood group-incompatible (ABOi) kidney transplantation is considered a safe procedure, with non-inferior outcomes in large cohort studies. Its contribution to living kidney transplantation programs is substantial and growing. The objective of this meta-analysis was to systematically investigate outcomes in ABO-incompatible kidney transplant recipients compared to center-matched ABO blood group-compatible (ABOc) control patients.. Methods Comprehensive searches were conducted in Embase, Medline, Cochrane, Web-of-Science and Google Scholar. MOOSE study guidelines for observational studies and Newcastle Ottawa bias scale were implemented to assess studies. Meta-analysis was performed using Review Manager 5.3. A subgroup analysis on antibody removal technique was performed.. Results After identifying 2728 studies addressing ABOi kidney transplantation, 26 studies were included, describing 1346 unique ABOi patients and 4943 ABOc controls. Baseline patient characteristics revealed no ...
The prevalence of malaria among 250 pregnant women attending antenatal clinic in Agbonchia Health Centre Eleme, Rivers State, Nigeria was investigated using thick and thin blood film stained with Giemsa. The stained slides were examined microscopically for malaria parasites. The prevalence of malaria among the pregnant women was 40.6% and the prevalence among 50 non-pregnant women used as control was 16.0%. The prevalence of malaria by age group among the pregnant women was 36.1-46.8% from age 20-40yrs. The prevalence of malaria by haemoglobin genotype are HbAA 42.4% and HbAS 34.6%, statistically at p,0.05 there is no significant difference in the prevalence of malaria between HbAA and HbAS, but there is significant difference in the prevalence of severe malaria between HbAA and HbAS. The prevalence of malaria among ABO blood groups showed that blood group O had the highest prevalence 44.4% but minimal episode of severe malaria compared with the other blood groups. Blood group O and HbAS ...
Principal Investigator:KOMINATO Yoshihiko, Project Period (FY):2003 - 2004, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Legal medicine
A blood type (also called a blood group) is a classification of blood based on the presence or absence of inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins or glycolipids, depending on the blood group system, and some of these antigens are also present on the surface of other types of cells of various tissues. Several of these red blood cell surface antigens, that stem from one allele (or very closely linked genes), collectively form a blood group system. Immunological effects of mismatched blood transfusions are much more likely to involve components of the ABO blood group system or the RhD antigen (also known as the Rhesus factor or Rhesus D antigen) of the Rhesus blood group system than components of any of the other blood group systems; hence, in the routine preparation of blood for transfusion in a blood bank, the presence or absence the immunogenic blood group antigens, the A antigen, the B antigen and the ...
Because blood tests are common many people have questions about the genetic information found in the ABO blood group and Rh system.
Introduction: Toxoplasma gondii infects humans in several manners including by the gastrointestinal tract where a-2-L-fucosyltransferase (FUTII) coded by the FUT2 gene (19q13.3) controls the expression of the ABH glycoconjugate profile. The presence of functional FUTII defines the secretor...
Every day, thousands of people need donated blood. But only blood without A- or B-type antigens, such as type O, can be given to all of those in need, and its usually in short supply. Now scientists are making strides toward fixing the situation. In ACS Journal of the American Chemical Society, they report an efficient way to transform A ...
The blood-type diet was popularized in the book Eat Right for Your Type, written by naturopath Peter DAdamo. The theory behind the diet is that the ABO blood type should match the dietary habits of our ancestors and people with different blood types process food differently. According to the theory, individuals adhering to a diet specific to ones blood type can improve health and decrease risk of chronic illness such as cardiovascular disease. The book was a New York Times best-seller that has been translated into 52 languages and sold over 7 million copies. The U of T researchers took an existing population of mostly young and healthy adults who provided detailed information about their usual diets and provided fasting blood that was used to isolate DNA to determine their ABO blood type and the level of cardiometabolic risk factors, such as insulin, cholesterol and triglycerides. Diet scores were calculated based on the food items listed in Eat Right for Your Type to determine relative ...
Meet your meter: The "Restrict to meter" strip above will show you the related words that match a particular kind of metrical foot. Meter is denoted as a sequence of x and / symbols, where x represents an unstressed syllable and / represents a stressed syllable. (See "Slash & x" notation for more info on how this works.) Once you select a meter, it will "stick" for your searches until you unselect it. Primary vowel: Try the "Primary vowel" option under the ...
Blood group O was associated with an increased prevalence of active placental infection in primiparae and with a reduced risk of placental malaria in multiparae. Placental parasitaemia occurs at least twice as frequently in primiparae but only among blood group O women. This effect of parity, that is one of the cardinal features of placental malaria, was not observed in non-O phenotypes for any of the placental malaria histological types.. In multiparae and specifically in mothers with past or non-infected placentae blood group O was also associated with higher mean feto-placental weight ratios compared to non-O individuals. These differences associated with multiparity can be interpreted to represent a parity-specific association of the blood group O phenotype with the protective malarial immunity which occurs in multigravidae [3]. Mean birth weight was also significantly increased in babies of primiparae with the O phenotype, suggesting that despite the greater susceptibility of primigravidae ...
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the Middle East Respiratory Syndrome, Severe Acute Respiratory Syndrome, and 2019-nCov. Coronaviruses can spread from animals to humans. Symptoms include fever, cough, shortness of breath, and breathing difficulties. In more severe cases, it can lead to death. Here is the latest research on coronaviruses. ...
ABO blood group rs8176719 represents a site in the ABO gene, often referred to as either c.261delG or, less commonly, c.260_262insG, and it is a key SNP in determining blood group type O status. [PMID 2333095] An allele that encodes either a blood group type A or type B will have a (G) at this SNP site, i.e. such an allele will be rs8176719(G). If a one-base deletion has occured at this site, removing this nucleotide all together, the corresponding allele is considered to be rs8176719(-) and encodes the most common blood group type O allele. However, an individual will typically only be blood group type O if they are carry two copies of (are homozygous) for this deletion, in other words, if their genotype is rs8176719(-;-). If they carry one copy, they could be blood type A, or blood type B (but are unlikely to be type O). A person who is rs8176719(G;G) is likely to be of blood type A, B, or AB, but due to the existence of (rare) nonfunctional O alleles brought about by (nondeletional) mutations ...
If the fathers blood type is O, its possible that he actually inherited an O allele from one of his parents and either an "A" or "B" allele from the other parent. Except there was a single base mutation in the (lets just call it) "A" allele from his parent and the "A" allele no longer functions. Instead, its a pseudo-O allele. Well, if that happened, then the father would have an O-"O" genotype and Type O blood. However, if there was a single base-pair mutation when his DNA was being copied during meiosis its possible that the pseudo-O allele could revert back to an active A allele. I have to imagine the odds of this happening are phenomonal, but then again, there are ~6.5 Billion people alive...thats a lot of trials.. ReplyDelete ...
Why dont antibodies of o blood group does not cause agglutination reaction with any of antigens in other blood group? Study Blood Types Review.
Researchers say they have discovered two enzymes that may safely convert blood groups A, B and AB to group O, the universal blood used in transfusions.. If this preliminary research can be applied to blood banks, the enzymes could be used to boost universal blood supplies, helping to overcome shortages.. The international research is published online in the journal Nature Biotechnology.. Under the ABO system of blood classification established in 1900, group O red cells can be given to all individuals. But A can only be given to A and AB individuals, and B can only be given to B and AB individuals.. Giving someone the wrong type can trigger a massive, sometimes fatal attack by the hosts immune system on the transfused cells. So for the past 25 years or so researchers have been testing the concept of creating universal blood cells by removing the surface molecules that trigger this immune response.. In 2000, findings from a trial showed that type B red blood cells could be converted into type ...
Research team identified 771,113 individuals with A,B and AB group and 519,743 with O blood group for the coronary events analysis.
Background: Graft immunocomplex capture fluorescence analysis (ICFA) is an attractive method to detect intra-graft donor-specific anti-HLA antibodies (HLA-DSA). In ABO incompatible (ABOi) transplantation, anti-A/B antibodies are also considered as important DSA (ABO-DSA). Thereupon, it is also useful to monitor intra-graft ABO-DSA to assess AMR by applying the ICFA technique.. Methods: To capture A/B antigens, anti-Band III, VW, and PLVAP beads were composed. The allograft specimen was dissolved in PBS by the lysis buffer. Anti A/B antibodies were added for a positive control sample. Subsequently, A/B antigens were captured by anti-Band III, VW, or PLVAP beads. Then, the immune complexes were detected by anti-human IgG antibodies (PE), analyzed by a Luminex system.. Results: Although Band III and VW beads indicated false-positive/negative, PLVAP beads were capable to capture A/B antigens with high sensitivity and specificity (,95%) provided that a ratio (sample/blank beads MFI) ,1.0 was ...
Human Blood Groups. Showing top 8 worksheets in the category - Human Blood Groups. Some of the worksheets displayed are Middle high school teachers guide, Blood types work, Students work, Genetics of blood types cloze work, Uc irvine focus 5 e lesson plan title are you my type a, Blood type inheritance name, Simulated blood typing whodunit lab activity student study, Name human body.. The ABO blood type system is based on glycoproteins (proteins attached to. And while, based on the genetics that youve learned so far, multiple alleles might.. of questions pertaining to the genetics of sickle cell disease and its relationship to malaria resistance. A few simple rules of blood type genetics are that.. - The Genetics of Blood Types Worksheet is suitable for 9th - 12th Grade. Human biology or genetics learners apply their knowledge to a unique situation: two newborn baby girls being possibly switched in.. Microscopic examination of synovial fluid can reveal crystal formation or the number of white ...
1. Rowley SD, Donato ML, Bhattacharyya P. Red blood cellincompatible allogeneic hematopoietic progenitor cell transplantation. Bone Marrow Transplant 2011;46:1167-85.. 2. De Mattos LC. Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates. Rev Bras Hemoter 2016;38:331-40.. 3. Crookston MC. Blood group antigens acquired from the plasma. Prog Clin Biol Res 1980;43:99-114.. 4. Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009;25:48-59.. 5. Hult AK, Dykes JH, Storry JR, Olsson ML. A and B antigens acquired by group O donor-derived erythrocytes following ABO-non-identical transfusion or minor ABO-incompatible haematopoietic stem cell transplantation. Trans Med 2017; 27:181-91.. 6. Judd WJ. Methods in immunohematology. 2nd ed. Durham, NC: Montgomery Scientific Publications, 1994.. 7. Cohn CS. Transfusion support issues in hematopoietic stem cell transplantation. Cancer Control ...
Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimers disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the use of Aβ-rich aqueous extracts of brain samples from AD patients as a source of human Aβ and live-cell imaging of iPSC-derived human neurons to develop a bioassay capable of quantifying the relative protective effects of multiple anti-Aβ antibodies. We report the characterization of 1C22, an aggregate-preferring murine anti-Aβ antibody, which better protects against forms of Aβ oligomers that are toxic to neurites than do the murine precursors of the clinical immunotherapeutics, bapineuzumab and solanezumab. These results suggest further examination of 1C22 is warranted, and that this bioassay maybe useful as a primary screen to identify yet more potent anti-Aβ therapeutics. The
Background: Transfusion-transmissible infectious agents such as hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphi...
The study is not the first to find an association between blood type and urinary cancer prognosis. Recently, Tobias Klatte, MD, of the Medical University of Vienna in Austria, and colleagues reported study findings showing that, among patients with non-muscle-invasive bladder urothelial carcinoma treated with transurethral bladder resection, those with blood type O had the highest rate of recurrence and progression. The findings were published online ahead of print in The Journal of Urology ...
Unit 9 Other Blood Group Systems Part 1. Terry Kotrla, MS, MT(ASCP)BB. Introduction. ISBT recognizes 30 blood group systems with over 600 antigens. Some VERY rare only found in certain ethnic groups. Some associated with diseases or resistance to infection. Most important are ABO and D...
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The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized epithelium from nine blood group A, two blood group B, and nine blood group O individuals. The blood group carbohydrate chains were examined in tissue sections by immunofluorescence microscopy. The A and B blood group antigens were detected by human blood group sera, and antigen H type 2 chains and N-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal ...
April is National Donate Life Month, and if youre thinking about donating a kidney, now would be the time to find out what its all about. Did you ever wonder how they match potential organ donors with people who need organs? There are more than 92,000 people in the United States who are waiting for a kidney transplant. More than 114,000 people are waiting for a lifesaving organ transplant of some kind. More than 16,000 kidney transplants were done last year and more than 5,000 of them were from live donors. So whats the secret to the perfect match? Ill answer that question with a few more questions. Whats Your Type? We first need to know your blood type. The blood types are O, A, B, and AB. Certain blood types can only be matched to other blood types in a specific way. Blood type O is a universal donor who can donate to any person on the list. If you are the kidney recipient with blood type O, then you can receive a kidney from another blood type O donor. If you have blood type A, your ...
Inheritance patterns of blood groups. Australian Red Cross Blood Service. Retrieved 30 October 2013. "ABO blood group system". ... Blood groups that children may inherit from their parents. Blood type distribution by country Consanguinity CRISPR DNA repair ... December 14, 2002 Singh, G; Johns, MM; Paul, G (1982). "Paternity testing: analysis of six blood groups and HLA markers, with ... "Blood-grouping tests in undisputed paternity proceedings". JAMA. 164: 249-250. doi:10.1001/jama.1957.02980030025006. "Mommy's ...
... also underpins the ABO blood group system. It is the presence or absence of glycosyltransferases which dictates ... which blood group antigens are presented and hence what antibody specificities are exhibited. This immunological role may well ... Glycosylation also plays a role in cell-to-cell adhesion (a mechanism employed by cells of the immune system) via sugar-binding ... These can be divided into four groups: disorders of protein N-glycosylation, disorders of protein O-glycosylation, disorders of ...
A famous example of this latter effect is the ABO blood group system.[citation needed] ... Glycoproteins are important for white blood cell recognition.[citation needed] Examples of glycoproteins in the immune system ... H antigen of the ABO blood compatibility antigens. Other examples of glycoproteins include: *gonadotropins (luteinizing hormone ... It is important[according to whom?] to distinguish endoplasmic reticulum-based glycosylation of the secretory system from ...
1993;64(2):120-3. Molecular genetic analysis of the ABO blood group system: 2. cis-AB alleles. Yamamoto F1, McNeill PD, ... in the ABO gene which complicates the basic inheritance pattern and blood-transfusion compatibility matching for ABO blood ... When testing paternity or maternity by ABO blood group alone, it is possible to have a paradoxical result in the rare instance ... 2004 Jul;87(1):41-3. The serological and genetic basis of the cis-AB blood group in Korea. Cho D1, Kim SH, Jeon MJ, Choi KL, ...
The A and B transferases are the foundation of the human ABO blood group system. Both A and B transferases are ... "Human ABO Gene". Retrieved 2 December 2013. Kidd, Kenneth. "ABO blood group (transferase A, alpha 1-3-N- ... "ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase ... ISBN 978-0-19-850673-7. O'Neil D. "ABO Blood Groups". Human Blood: An Introduction to Its Components and Types. Behavioral ...
ISBN 978-0-7167-8590-3. CS1 maint: Multiple names: authors list (link) ABO blood group system Alloimmunity Antibodies. ... on the RBCs of other blood groups. In a person with A blood group, the plasma will contain isoantibodies against B antigens, so ... Isoantibodies are seen in people with different blood groups. The anti-A or anti-B isoantibodies or both (also called ... in the first years of life can cross react with ABO-incompatible red blood cells when it comes in contact with during blood ...
Further information: ABO blood group system. Prior to the 1952 confirmation of DNA as the hereditary material by Alfred Hershey ... Blood groups are inherited from both parents. The ABO blood type is controlled by a single gene (the ABO gene) with three ... and Martha Chase, scientists used blood proteins to study human genetic variation.[97][98] The ABO blood group system is widely ... Blood groupsEdit. Frequency of O group in indigenous populations. Note the predominance of this group in Indigenous Americans. ...
Karl Landsteiner makes the first discovery of blood types, identifying the ABO blood group system. Jokichi Takamine and Keizo ...
Her ABO blood group system is type A. Her hobby and special skill is swimming. She played Miyabi Aizawa in the television drama ...
1997). "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". ... 1996). "Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel ... Isolation of a candidate for the human Secretor blood group locus". J. Biol. Chem. 270 (9): 4632-9. doi:10.1074/jbc.270.9.4632 ... 1995). "Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H ...
The ABO blood group system is determined by what type of glycosyltransferases are expressed in the body. The ABO gene locus ... whole cell-based systems using either endogenous glycosyl donors or cell-based systems containing cloned and expressed systems ... Mannosyl groups may be transferred to tryptophan to generate C-mannosyl tryptophan, which is relatively abundant in eukaryotes ... This results in H antigen remaining unchanged in case of O groups. The combination of glycosyltransferases by both alleles ...
The story ends with a speculation that the ABO blood group system in humans and chimps are examples of trans-specific ... This diverse group includes the echinoderms, along with some organisms labelled "worms" and even Xenoturbella, which until 2016 ... Very large group of light harvesters and their kin. excavates, SAR supergroup, 20 species of single-celled glaucophytes, over ... An extremely diverse group of 2000 species join here, including Carnivora (dogs, cats, bears and seals), Perissodactyla (horses ...
The use of O as a number can lead to confusion as in the ABO blood group system. Blood can either contain antigen A (type A), ... blood type O' is usually written with a letter O and not with a number 0 as in most other European languages. "Zilch" is a ...
All the common blood types, such as the ABO blood group system, are genetic polymorphisms. Here we see a system where there are ... Polymorphisms in this gene are the basis of the Duffy blood group system. In humans, a mutant variant at a single site in the ... Although a polymorphism can be controlled by alleles at a single locus (e.g. human ABO blood groups), the more complex forms ... Which Encodes the Major Subunit of the Duffy Blood Group System and the Receptor for the Plasmodium vivax Malaria Parasite". ...
"Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". ... Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, Lowe JB (June 1994). "Molecular basis for H blood group deficiency in ... H blood group)". Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gérard G, Oriol R (July 1991). "The human chromosome 19 ... beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen". Proceedings of the National ...
With respect to the glycosylation, vWF is one of only a few proteins that carry ABO blood group system antigens. Multimers of ... Occurrence is not affected by ADAMTS13, and the only significant genetic factor is the person's blood group.High plasma vWF ... Levy GG, Motto DG, Ginsburg D (July 2005). "ADAMTS13 turns 3". Blood. 106 (1): 11-7. doi:10.1182/blood-2004-10-4097. PMID ... rapid blood flow in narrow blood vessels, see below). vWF binds to other platelet receptors when they are activated, e.g., by ...
In the common ABO blood group system, there are 4 blood types (A, B, O, AB). ... The smallest non-cyclic group has four elements; it is the Klein four-group. Four is also the order of the smallest non-trivial ... Four cardinal directions, four seasons, the duodecimal system, and the vigesimal system are based on four. ... In the standard bonus points system, a point is awarded in the league standings to a team that scores at least 4 tries in a ...
... is a component of the antigens present on blood cells that determine blood type within the ABO blood group system. In ... In the beta form, the alcohol group is in the equatorial position, whereas in the alpha form, the alcohol group is in the axial ... However, most lactose in breast milk is synthesized from galactose taken up from the blood, and only 35±6% is made from ... Bhat, Paike Jayadeva (2 March 2008). "Galactose Regulon of Yeast: From Genetics to Systems Biology". Springer Science & ...
The ABO blood group system is widely credited to have been discovered by the Austrian Karl Landsteiner, who found three ... Blood groups are inherited from both parents. The ABO blood type is controlled by a single gene (the ABO gene) with three ... and biologists have reached a similar conclusion based on analysis of Amerindian language groups and ABO blood group system ... May 2010). "Blood group O alleles in Native Americans: implications in the peopling of the Americas". Am. J. Phys. Anthropol. ...
The ABO blood group system differs among humans, but the human reference genome contains only an O allele (although the other ... The human and mouse reference genomes are maintained and improved by the Genome Reference Consortium (GRC), a group of fewer ... ten male and ten female volunteers were invited to make an appointment with the project's genetic counselors and donate blood ...
... is a component of the antigens present on blood cells that determine blood type within the ABO blood group system. In ... In the beta form, the alcohol group is in the equatorial position, whereas in the alpha form, the alcohol group is in the axial ... However, most lactose in breast milk is synthesized from galactose taken up from the blood, and only 35±6% is made from ... transfers a UMP group from UDP-glucose to Gal-1-P to form UDP-galactose; and finally, UDP galactose-4'-epimerase (GALE) ...
It was later discovered that the ABO blood group system is not just common to humans, but shared with other primates, and ... Before the discovery of DNA, scientists used blood proteins (the human blood group systems) to study human genetic variation. ... It was expected that groups with similar proportions of blood groups would be more closely related, but instead it was often ... "The ABO blood group is a trans-species polymorphism in primates". Proceedings of the National Academy of Sciences. 109 (45): ...
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the ... Avent ND, Reid ME (2000). "The Rh blood group system: a review". Blood. 95 (2): 375-87. PMID 10627438. Flegel WA, Wagner FF ( ... "Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system". Hum. Genet. 91 (2): 157-62 ... "Molecular genetic basis of the human Rhesus blood group system". Nat Genet. 5 (1): 62-5. doi:10.1038/ng0993-62. PMID 8220426. " ...
... from Karl Landsteiner's discovery of the ABO blood group system onwards, permit organ transplants to take place. The ... One specialised area is the immune system, with its own ultra-variable set of proteins. They are not only complicated, but have ... These last are elements of the immune system which recognise cancer cells as non-self and kill them, defend against infection ... The Compatibility Gene is a 2014 book about the discovery of the mechanism of compatibility in the human immune system by ...
Karl Landsteiner's discovery of the ABO blood group system in 1900 was based on an analysis of blood samples from six members ... In the last test his eyes were bloodied as blood vessels burst in his eyes. These tests were carried out for the US Air Force ... With this in place, over a 3-month period, he conducted a number of experiments linking his nervous system with the internet. N ... An issue peculiar to AIDS vaccine research is that the test will leave HIV antibodies in the volunteers blood, causing the ...
2: The ABO Blood Group System and ABO Subgroups. Biotec. March 2005. Archived from the original on 2007-02-06. http://web. ... "Turkey Blood Group Site". Kangrubu.com. பார்த்த நாள் 2010-11-19. *↑ "Frequency of major blood groups in the UK". Blood.co.uk. ... Dean L (2005). "Chapter 5: The ABO blood group.". Blood Groups and Red Cell Antigens. பார்த்த நாள் 2007-03-24. ... to histo-blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or ...
ABO blood group system, classification of human blood as determined by the presence or absence of A and B antigens on red blood ... race: Mendelian heredity and the development of blood group systems. Once the ABO blood group system was discovered and was ... ABO blood group system, the classification of human blood based on the inherited properties of red blood cells (erythrocytes) ... More About ABO blood group system. 6 references found in Britannica articles. Assorted References. *major reference* In blood ...
What is ABO blood group system? ABO blood group system meaning. ABO blood group system sense. ABO blood group system FAQ. ABO ... ABO blood group system definition. Explain ABO blood group system. ... ABO blood group system. Search Dictionary: ABO blood group system Definition. *(n) a classification system for the antigens of ... ABO blood group system. English Dictionary -> Letter A -> ... ABO blood group system Synonyms. *ABO blood group system. *ABO ...
Antonyms for ABO blood group system. 2 synonyms for ABO blood group system: ABO group, ABO system. What are synonyms for ABO ... Synonyms for ABO blood group system in Free Thesaurus. ... ABO blood group system synonyms, ABO blood group system ... ABO blood group system. Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.. Related to ABO blood group system: Rh ... Synonyms for ABO blood group system. a classification system for the antigens of human blood. Synonyms. *ABO group ...
ABO blood group system, age, sex, risk factors and cardiac infarction. Arch Gerontol Geriatr. 1985;4:241-249. ... The highest risk was observed for blood group AB, followed by blood groups B and A. The association between ABO blood group and ... Assessment of ABO Blood Group. The assessment of ABO blood group has been described in detail elsewhere.23 Briefly, in both the ... ABO blood group has been associated with plasma lipid levels; in particular, the A blood group has been noted to have higher ...
2 ABO, H, and Lewis systems.. 3 MNS Blood Group System.. 4 P Blood Groups. ... Yet, in the six years since the first edition of Human Blood Groups was published, new blood groups have been discovered, ... Contains latest information on the genes for various blood groups. * More information on the functional aspects of blood groups ... several blood group genes have been cloned, and the molecular backgrounds of numerous blood group variants have been worked out ...
Distribution of study participants based on gender and history of gastritis in either systems of blood grouping shoed no ... Keywords: Blood groups, ABO groups, Rh groups, gastritis Abstract. Background & Objectives: The various ABO and Rh blood groups ... ABO group is found to linked with chronic gastritis. The aim of this study was to estimate the frequencies of ABO and Rh blood ... Relationship of ABO and Rh blood groups with history of gastritis in the undergraduate medical and dental students: a cross- ...
keywords = "ABO blood group, Blood donor, Conventional tile method, RhD blood group, Solid-phase method", ... InTec Blood Grouping Test Kit) with the conventional tile method in determining the ABO and RhD blood group of healthy donors. ... InTec Blood Grouping Test Kit) with the conventional tile method in determining the ABO and RhD blood group of healthy donors. ... InTec Blood Grouping Test Kit) with the conventional tile method in determining the ABO and RhD blood group of healthy donors. ...
Inheritance patterns of blood groups. Australian Red Cross Blood Service. Retrieved 30 October 2013. "ABO blood group system". ... The ABO blood group". Blood Groups and Red Cell Antigens. Retrieved 24 March 2007. Farr A (1 April 1979). "Blood group serology ... Kidd blood group The Editors of Encyclopædia Britannica (2017-07-18). "ABO blood group system". Encyclopædia Britannica. ... ABO at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ABO blood groups, antibodies and antigens explained ...
Group by relation. Alphabetize. Synonyms and other words related to abo blood group system: ...
The blood group phenotypes were detected by the classic slide method. The ABO blood group ... ... Distribution of ABO and Rh D blood groups in the population of Poonch district, Azad Jammu and Kashmir  ... We evaluated the distribution of ABO and Rhesus [‎Rh]‎ D blood groups in the population of Poonch district in Azad Jammu and ... There is strong evidence to suggest that there is an association between ABO blood group and certain diseases. This study in ...
Discuss) The ABO blood group system is the most ... ABO blood group system It has been suggested that this article ... The ABO blood group system is the most important blood type system (or blood group system) in human blood transfusion. The ... There are numerous popular myths surrounding ABO blood groups. These beliefs have existed since the ABO blood groups were ... Human blood group systems - Blood type. ABO - Chido-Rodgers - Colton - Cromer - Diego - Dombrock - Duffy - Gerbich - GIL - Hh ...
What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, ... on the molecular genetic basis of histo-blood group ABO system. The title of his talk was ... including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, ... ABO BLOOD GROUP SYSTEM LECTURE SLIDE 003: ABO phenotype is a hereditary trait. ...
What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, ... on the molecular genetic basis of histo-blood group ABO system. The title of his talk was ... including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, ... ABO BLOOD GROUP SYSTEM LECTURE SLIDE 072: Two additional cDNA libraries were constructed and screened. ...
... ) as well as the differences in their chemical structures in this interactive tutorial. ... As well as the ABO blood group systems, 29 other blood group systems have been identified. These blood groups have names such ... Introduction to the ABO Blood Group System:. Red Blood cells make (synthesize) several types of surface marker molecules. ... The ABO blood group antigens are genetically determined, and the incidence of each group varies by race. ...
ABO blood groups, antibodies and antigens explained YouTube educational video. *Encyclopædia Britannica, ABO blood group system ... Based on this he classified human bloods into three groups, namely group A, group B, and group C. He defined that group A blood ... Kidd blood group. References. *↑ The Editors of Encyclopædia Britannica (2017-07-18). "ABO blood group system". Encyclopædia ... "The ABO blood group system and Plasmodium falciparum malaria". Blood. 110 (7): 2250-2258. doi:10.1182/blood-2007-03-077602. ...
9. blood (n.). the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, ... 2. system (n.). a group of independent but interrelated elements comprising a unified whole ... 7. system (n.). a group of physiologically or anatomically related organs or parts ... Synonym.com 2001-2018 Leaf Group Ltd. // Leaf Group Education, all rights reserved. Database is based on WordNet 3.0, a lexical ...
ABO blood group systemAntigenBloodBlood transfusionBlood typeCentre for Blood ResearchEnzymeImmune systemJournal of the ... Transforming all donated blood into a universal type Every day, thousands of people need donated blood. But only blood without ...
An individual of group O blood, does not possess A or B antigens on the red blood cells but the plasma contains both anti-A and ... An individual of group AB blood, simultaneously possesses both the A and B antigen on the red blood cells, but no anti-A or ... In an individual of group A blood, the red blood cells present, at their surface, the type A antigens only. The plasma only ... Also it addresses the inheritance of blood groups by using a pedigree chart. Red blood cells (called erythrocytes) are the ...
Research: ABO/Rhesus blood group systems and malaria prevalence among students of the University of Dschang, Cameroon. April 14 ... Home » Research: ABO/Rhesus blood group systems and malaria prevalence among students of the University of Dschang, Cameroon ... Blood group O was most common (48.8%), followed by blood group A (25.8%), B (23.0%) and AB (2.4%). Total percentage of rhesus ... to examine the relationship between ABO blood group, rhesus factor and prevalence of Plasmodium falciparum infection. Blood ...
ABO Blood-Group System -- Popular Works The Resource ABO Blood-Group System -- Popular Works Label ABO Blood-Group System -- ... Context of ABO Blood-Group System -- Popular Works Subject of. * Eat right for your baby : the individualized guide to ... Data Citation of the Concept ABO Blood-Group System -- Popular Works. Copy and paste the following RDF/HTML data fragment to ... 1 Items that are about the Concept ABO Blood-Group System -- Popular Works ...
ABO blood group system: …have type A, type B, type O, or type AB blood. The A, B, and O blood groups were first identified by ... Other articles where Type O blood is discussed: ... ABO blood group system. * In ABO blood group system. …have type ... The A, B, and O blood groups were first identified by Austrian immunologist Karl Landsteiner in 1901. See blood group. ... In therapeutics: Blood and blood cells. types A, B, and O were identified and cross-matching of the donors blood against that ...
Master ABO Blood Group System with Dr. Najeeb Lectures. Worlds Most Popular Medical Lectures. Trusted by millions of students ... ABO Blood Group System - Teaser video. This is a teaser video. Watch the complete lecture in members area. If you are not a ... 1. ABO antigens and ABO antibodies.. 2. Introduction to ABO blood group system. ...
The ABO blood group system is the most important blood type system (or blood group system) in human blood transfusion. The ... Human blood group systems - Blood type ABO - Chido-Rodgers - Colton - Cromer - Diego - Dombrock - Duffy - Gerbich - GIL - Hh - ... Main article: Psychological aspects of blood ABO blood group antigens present on red blood cells and IgM antibodies present in ... ABO hemolytic disease of the newborn. Edit. Main article: ABO hemolytic disease of the newborn ABO blood group ...
ABO Blood-Group System. Grant support. *CA73790/CA/NCI NIH HHS/United States ... Genotype-Derived ABO Blood Group Alleles and the Risk of Pancreatic Cancer: Data from the Pancreatic Cancer Cohort Consortium ... Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.. Wolpin BM1, Kraft P ... Risk of pancreatic cancer in non-O blood type versus O blood type by prospective cohort study* ...
F - Unlike other blood group systems, ABO and 6 of the currently known carbohydrate blood group systems (P1PK, Lewis, H, I, ... Unlike other blood group systems, ABO and 6 of the currently known carbohydrate blood group systems (P1PK, Lewis, H, I, ... Test Your Knowledge - ABO Blood Group System. A Blog from Eric Ching:. For some of us working at Canadian Red Cross in the 70s ... The ABO blood group system revisited. A Review and Update. Immunohematology 2009;25:48-59 ...
  • abstract = "Introduction: 'InTec Blood Grouping Test kit' using solid-phase technology is a new method which may be used at outdoor blood donation site or at bed side as an alternative to the conventional tile method in view of its stability at room temperature and fulfilled the criteria as point of care test. (elsevier.com)
  • it is believed that the stimulus for such antibody formation is from contact with ABO-like antigenic substances in nature. (britannica.com)
  • This study aimed to compare the efficiency of this solid phase method (InTec Blood Grouping Test Kit) with the conventional tile method in determining the ABO and RhD blood group of healthy donors. (elsevier.com)
  • Methods: A total of 760 voluntary donors who attended the Blood Bank, Penang Hospital or offsite blood donation campaigns from April to May 2014 were recruited. (elsevier.com)
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