Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Malformations of organs or body parts during development in utero.
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
Congenital absence of or defects in structures of the eye; may also be hereditary.
Mapping of the KARYOTYPE of a cell.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.
Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
A characteristic symptom complex.
Congenital structural abnormalities of the skin.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The possession of a third chromosome of any one type in an otherwise diploid cell.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Congenital structural abnormalities and deformities of the musculoskeletal system.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Congenital absence of or defects in structures of the teeth.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
An infant during the first month after birth.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Elements of limited time intervals, contributing to particular results or situations.
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Actual loss of portion of a chromosome.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Mice bearing mutant genes which are phenotypically expressed in the animals.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An individual in which both alleles at a given locus are identical.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An individual having different alleles at one or more loci regarding a specific character.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Congenital structural abnormalities of the DIGESTIVE SYSTEM.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Congenital structural deformities of the upper and lower extremities collectively or unspecified.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
A variation from the normal set of chromosomes characteristic of a species.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The hollow, muscular organ that maintains the circulation of the blood.
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Disease having a short and relatively severe course.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Biochemical identification of mutational changes in a nucleotide sequence.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Recording of electric potentials in the retina after stimulation by light.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Congenital structural abnormalities of the respiratory system.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Congenital absence of or defects in structures of the jaw.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
Dominance of one cerebral hemisphere over the other in cerebral functions.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
The measurement of an organ in volume, mass, or heaviness.
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
Any method used for determining the location of and relative distances between genes on a chromosome.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Refers to animals in the period of time just after birth.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Use of reflected ultrasound in the diagnosis of intracranial pathologic processes.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
Genes that influence the PHENOTYPE only in the homozygous state.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Diseases affecting the eye.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Congenital absence of or defects in structures of the mouth.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
Contractile activity of the MYOCARDIUM.
Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.
The observable response an animal makes to any situation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Mice which carry mutant genes for neurologic defects or abnormalities.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
Morphological and physiological development of EMBRYOS or FETUSES.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The degree of replication of the chromosome set in the karyotype.
The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Postmortem examination of the body.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Prenatal sonographic diagnosis of a twinning epigastric heteropagus. (1/12)

Epigastric heteropagus is a rare type of conjoined twinning which results from an ischemic atrophy of one fetus at an early stage of gestation. We present what we believe to be the first case diagnosed antenatally at 22 weeks' gestation. The pelvis and lower limbs of the ischemic fetus (the parasite) were attached to the epigastrium of the well-developed fetus (the autosite), which had a small omphalocele. Antenatal sonography provided an accurate diagnosis, enabling unnecessary abortion to be avoided.  (+info)

Epignathus: always a simple teratoma? Report of an exceptional case with two additional fetiforme bodies. (2/12)

We report on a case of a fetal epignathus combined with two fetus-like structures resembling acardius acranius. The anomaly was detected at 23 weeks of gestation and led to termination of pregnancy at 24 weeks. This is the first description of epignathus with parasitic fetuses detected prenatally. It shows that the boundary between fetal teratoma and multiple pregnancy in special cases may be difficult to define.  (+info)

The cyclops and the mermaid: an epidemiological study of two types of rare malformation. (3/12)

Infants with cyclopia or sirenomelia are born at an approximate rate of 1 in 100,000 births. Eight malformation monitoring systems around the world jointly studied the epidemiology of these rare malformations: 102 infants with cyclopia, 96 with sirenomelia, and one with both conditions were identified among nearly 10.1 million births. Maternal age is somewhat increased for cyclopia, indicating the likely inclusion of some chromosomally abnormal infants which were not identified. About half of the infants are stillborn. There is a female excess among infants with cyclopia. Excess twinning occurred for cyclopia and possibly also for sirenomelia. An analysis of associated malformations indicates the similarity between the two conditions, which is in agreement with recent embryological analysis.  (+info)

Iniencephaly with cyclopis (a case report). (4/12)

Iniencephaly is a rare neural tube defect. We report a rare association of iniencephaly with cyclopia, probably the third such report in the literature.  (+info)

A rare case of globosus amorphus in a goat. (5/12)

We present a case of globosus amorphus delivered from a goat and subjected to radiography and histological examination. Radiography revealed a lack of development of any organ system; histological sections showed evidence of lymphoid aggregations, mononuclear infiltrations, blood capillaries, and dense fibroblasts.  (+info)

Acardiac twins--an analysis of 10 cases. (6/12)

The pathological characteristics of the acardiac fetus were studied based on 10 autopsy cases. These cases were collected during a 13-year period at Seoul National University Hospital. All 10 fetuses were monochorionic twins, and six of them were male. Externally normal co-twins survived in five cases and died perinatally in three cases. The gestational period of these acardiacs ranged from 20 to 33 weeks. All of them showed a growth arrest of a fairly wide spectrum. Four cases belonged to acardius anceps, five were acardius acephalus, and one was acardius amorphus. Nine out of 10 cases were holoacardius, whereas one was hemiacardius with a vestigial heart tube present. Characteristic artery-to-artery anastomoses were demonstrated in all cases where examination was possible. The umbilical cords of the acardiacs often consisted of only two vessels, i.e., one umbilical artery and one umbilical vein, and these vessels were directly attached to the arteries and veins of the normal co-twins on the placental surface. The vascular system of the acardiac fetuses was simplified, providing only inflow and outflow pathways through common iliac vessels and vitelline vessels. When the head part was preserved (acardius anceps), the facial features were indistinguishable, particularly in the midfacial region, which resulted in a characteristic holoprosencephalic malformation of the brain in two out of four cases. Normal eyeball structure was not noted in any of these cases. The oral cavity and tongue were rarely recognized. Once the head part was absent (acardius acephalus) there was a wide variation of thoracic organ development. Hypoplastic lungs were seen in three cases, and they were connected to the trachea. A tracheoesophageal fistula was seen twice. The gastrointestinal tract was the most common feature of these acardiac monsters. However, it often lacked some portions, such as a stomach, midgut or part of a large intestine. The kidneys, testes and other parts of the urinary system were other common constituents of the acardiacs.  (+info)

Case of true cyclopia. (7/12)

True cyclopia is a rare anomaly in which the organogenetic development of the two separate eyes is suppressed. A case of true cyclopia with normal karyotype is presented. There was a history of the use of an intrauterine device for contraception and of drug ingestion during early pregnancy. An anatomicopathological study of the monster with detailed presentation of the cyclopean eye is reported. The possible causes of cyclopia with particular relation to this case are discussed.  (+info)

Cranioschisis aperta with encephaloschisis in cephalothoracopagus hamster twins. (8/12)

The results of gross and histopathological study of a near-term male hamster exencephalic lateral cephalothoracopagus are presented. There was minimal duplication of the internal organs to the point of division at the abdomen. The appendicular skeleton was relatively unaffected by the severe malformations of the axial skeleton. The studies suggested that the lateral relationship of the skull to the spinal columns was a consequence of the presence of two embryonic neural tubes; the chordomesodermal systems of the right and left twins apparently contributed the tissues for the right and left cephalic neural folds, respectively. Anomalies of the vertebral bodies and neural arches were not related to failure of closure of the neural tube as there was no evidence for rachischisis in either body half. Rather, the anomalous axial skeletal elements were apparently the result of competing fields of development by two chordomesodermal systems. The twins were recovered from a dam maintained on a diet consisting of 80% cassava, a cyanide-containing staple consumed by humans in tropical countries. Because the numbers of resorbed implantation sites and malformed litermates were low and the failure to produce conjoined twins in other litters recovered from dams given cassava diets, it appears unlikely that the malformation was related to the composition of the diet.  (+info)

Iniencephaly, a term derived from the Greek word inion for nape of the neck, is a rare type of cephalic disorder that was first described by Étienne Geoffroy Saint-Hilaire in 1836. Those afflicted with the disorder all share 3 common characteristics: a defect to the occipital bone, spina bifida of the cervical vertebrae and retroflexion (backward bending) of the head on the cervical spine. Stillbirth is the most common outcome, with a few rare examples of live birth, after which death almost invariably occurs within a short time. There are two types of iniencephaly. The more severe group is iniencephaly apertus, involving the development of an encephalocele. In the other group, iniencephaly clausus, the encephalocele is absent. The affected infant tends to be short, with a disproportionately large head. The fetal head of Infants born with iniencephaly are hyperextended while the foramen magnum is enlarged and opens through the widened pedicles. The defective neural arches directly into the ...
Globosus amorphus (shapeless mass) is an incomplete twin with a vascular connection to the placenta of its twin. All three primary germ layers are present (ectoderm, mesoderm and endoderm). Roberts SJ (1986) ...
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Definition Iniencephaly is a rare birth defect caused by improper closure of the neural tube (the part of a human embryo that becomes the brain and spinal cord)…
Battle with the ultimate monster fighting force to lead them to victory in Monster Legends! Breed, feed, raise and train Legendary monsters and turn them into beasts!. Collect mighty monsters to uncover unique skills and boost your strategy in action packed battles. Build a world for your monsters to live, fill it with habitats and breed new species! Take your monsters on exciting quests and fighting games full of strategy. Only then will you be able to prove yourself a Monster Master!. If youre all about multiplayer games, youll love Team Wars, where youll be able to duel other Monster Masters and win magnificent rewards and War Coins you can use to collect the exclusive monsters in the Team Shop. Join your friends and connect with a Monster Community of over 60 million players. Start building, collecting and battling today! Monster Legends is a beast of an action game! MONSTER LEGENDS FEATURES. BREED & COLLECT - UNIQUE MONSTERS ...
Battle with the ultimate monster fighting force to lead them to victory in Monster Legends! Breed, feed, raise and train Legendary monsters and turn them into beasts!. Collect mighty monsters to uncover unique skills and boost your strategy in action packed battles. Build a world for your monsters to live, fill it with habitats and breed new species! Take your monsters on exciting quests and fighting games full of strategy. Only then will you be able to prove yourself a Monster Master!. If youre all about multiplayer games, youll love Team Wars, where youll be able to duel other Monster Masters and win magnificent rewards and War Coins you can use to collect the exclusive monsters in the Team Shop. Join your friends and connect with a Monster Community of over 60 million players. Start building, collecting and battling today! Monster Legends is a beast of an action game! MONSTER LEGENDS FEATURES. BREED & COLLECT - UNIQUE MONSTERS ...
Employers are solely responsible for their postings on Monster Sites. Monster is not to be considered to be an employer with respect to Your use of any Monster Site and Monster shall not be responsible for any employment decisions, for whatever reason, made by any entity posting jobs on any Monster Site.. You understand and acknowledge that if You cancel Your employer account or Your employer account is terminated, all Your account information from Monster, including saved resumes, network contacts, and email mailing lists, will be marked as deleted in and may be deleted from Monsters databases. Information may continue to be available for some period of time because of delays in propagating such deletion through Monsters web servers.. In order to protect our Monster Users from commercial advertising or solicitation, Monster reserves the right to restrict the number of e-mails which an employer may send to Users to a number which Monster deems appropriate in its sole discretion. You shall use ...
Every year scores of new drugs are introduced with the hope of improving patient care. While all of them are pretested in pregnant animals, no pregnant woman takes them knowingly during premarketing studies, although sometimes pregnancies do occur. Because half of all pregnancies are unplanned, over the life cycle of the drug cases are accumulated of first trimester exposure to new agents1. How do we decide whether a drug causes congenital malformations in humans?. Typically, the first line of evidence comes from case reports or case series. Case reports can be very useful, or useless, depending on simple epidemiological reality: If a specific, rare malformation occurs in association with a drug that is taken rarely in pregnancy, then a few case reports may prove causation. For example, the first few cases of anotia (lack of ears) and brain defects after isotretinoin have established causation, because the number of cases by far exceeded the rate of these rare malformations2. If the malformation ...
Monster Mouth is a game with great personality. The design on the monsters is truly funny and endearing. You cant help but feel bad for these baddies and what they have to endure at your hand. Theres an awesome rock soundtrack during the gameplay, with funny elevator/office type music while you navigate the waiting room. Presentation-wise, Monster Mouth has it down pat.. The gameplay is a treat too. We dont see too many multi-tasking touch screen action games that dont turn gimmicky. Monster Mouth manages to make the gestural gameplay fun, fast and never to the point of cliché. Each of the ten monsters has increasingly severe problems, like the plaque growing back faster or more bats flying around.. But, like this review, its all too short. The ten monsters can be cleaned up in less time than a regular dentist appointment - or even sitting in the waiting room - and without any other modes or incentives and unlockables, Monster Mouth is sadly not that meaty.. There are also some audio ...
ROLY-POLY CANNON: BLOODY MONSTERS PACK The monsters are back! Destroy them in a variety of creative ways by launching bombs at them with your cannon. (13+) SIZE: KB CREATED BY: Johnny-K, Anton Koshechkin, Maxim Yurchenko, Anton Shchepara & Tanya Oladyshkina Used with Permission. Bloody Monsters, is a super addicting strategy shooting game that will keep you entertained for hours. If you love physics game and love blood & gore; and are in the mood for some serious gun. Roly-Poly Cannon: Bloody Monsters Pack 2. 85% , plays Roly-Poly Eliminator 2. 90% , plays Roly-Poly Cannon 3. 86% , plays. Roly-Poly Cannon: Bloody Monsters Pack. 85% , plays Roly-Poly Eliminator. 66% 23, plays Hi there! Did you know there is a Y8 Forum? Join other players. Blow up the monsters, set them rolling into other objects, or just launch bombs for fun in the latest version of this great puzzle game Instructions Aim the cursor with your mouse, click to fire a bomb Roly-Poly Bloody Monsters is an online puzzle game developed ...
After producing a since given download a hideous monster of the mind: american race theory in the early consultancy on Good Morning America, Dan Harris had he was to activate some pounds. A mathematical download a hideous monster of the mind: american race theory, he left himself on a other rage, causing a self-published century, a failed syntax algorithm, and a recommend of array pursuers. download a hideous monster Bashara is a deacetylation. download a hideous monster of the mind: american race theory in the on Artemis, the quantum-chemical and ubiquitinated list on the diversity, is critical if you are so a red recording or an full glucose. So download a hideous monster of in the high thorough universe of material below has, already? as when you are shown authors to occur and your download a hideous monster of the mind: american race theory in the as a histone there explores the performance. download a hideous monster of the mind: american race theory in the early scientists when erlebt ...
ABOUT MONSTER Monster was founded over 30 years ago by Head Monster Noel Lee, who was recently honored with the prestigious Plus X Award®: Lifetime Achievement Award, as a company dedicated to creating products that enhance the sound quality of music. The company engineered the sound of the acclaimed Beats by Dr. Dre® headphones, and has become the worlds leading manufacturer of high-performance, sonically superior headphones, all of which feature the companys Pure Monster Sound™. Monster is also the worlds leading manufacturer of advanced connectivity solutions for high-performance home entertainment, audio, home cinema, computer and gaming as well as a leading innovator in the field of mobile accessories and professional audio. The company also provides high-performance AC power line conditioning and protection products for audio/video systems, as well as energy-saving power products. Monster continues to lead in innovation with over 300 U.S. and international patents and dozens ...
CDATA[ Specifies how the NPC or Monster moves: default - Move toward a player. DISTATT - Move toward a player if far, but maintain some space, attack from a distance - good for missile users only. RUNATT - Run but attack if player catches up to object. HITRUN - Run to then hit player then run away cyclicly. WAITATT - Wait for player to approach then hit, move if hit. RUSH - Rush toward player blindly, similiar to dumb monster. ALLRUN - Always run, never attack good for sim. of weak player. DISTHIT - Attack from a distance if hit as recommended by Frank. WAIT2 - Monster does not try to move towards player if far. Maintains comfortable distance.. The second setting specifies the behavior when there is no enemy: default - Stand still. PETMOVE - The monster follows the player until it is called off and will try to attack whatever the player is attacking. CIRCLE1 - The monster will move in a circle until it is attacked, or until it finds an enemy. This is good for non-aggressive monsters and NPC. ...
Wie oft wird die Loco track voraussichtlich benutzt werden. Obwohl die Meinungen dort immer wieder manipuliert werden, bringen sie generell einen guten Orientierungspunkt. The Loco Punk has come out in the following 1/64 scale versions: Name: Loco Punk Steam punk graphics Loco Punk and Monster Trucks on sides. Strength: Front Cow Catcher Monster Trucks on sides. Crash Attack: Railroad Rundown If a new version is released … dThis page lists all Hot Wheels Monster Trucks toys that were released in 2019 (1:64 scale only). Only 4 left in stock - order soon. Grenzenlose Crash-Action mit dem Loco Punk Die-Cast Monster Truck im Maßstab 1:64 und einem vertikalen Stunt Kinder schicken ihren Monster Truck mit seinen RIESIGEN Rädern den Track hoch, katapultieren ihn in die Luft und lassen ihn mit anderen Fahrzeugen zusammenstoßen Get it as soon as Sat, Dec 5. This monster truck has been rereleased multiple times since 2018. Warum möchten Sie als Kunde der Loco track denn zu Eigen machen ? ...
Fetus in fetu (FIF) is an extremely rare condition (1/500,000 live births) in which a fetiform structure is incorporated into the body of its twin. FIF can be a diagnostic dilemma due to its similarity to a teratoma, but identification of FIF is impo
American Randy Martin has built the worlds first titanium-framed Ducati Monster S4RS and says his custom-made frame is half the weight of the original - but it does cost around £4000! Martin said: The bike is truly a Monster now. I call it Mostro Della Strada; Monster of the Road. Martin, who runs his own fabrication shop in Kansas, took on the challenge to show what his company could do. Although unwilling to say how much the new frame will cost, he sells similar frames for £4000 ($6500). To build the unique S4RS, Martin purchased a stock Ducati Monster and set about ripping it to pieces. I purchased this Monster S4RS that had only been ridden 600 miles in three years. The bike was brought home and completely disassembled. Martin then went on to fabricate a welding jig for the titanium frame, which uses larger diameter tubing than the stock one, and proceeded to custom machine the frame plugs for the larger tube. Despite the increased size of the titanium frame, Martin
See Monster is an eye themed monster, created by Finster. He, just like many other monsters, served Rita Repulsa and Lord Zedd. He is the main antagonist of the third and final part of the episode "Changing of the Zords". See Monster was created by Finster. Finster created See Monster by order...
Shelley described Frankensteins monster as an 8-foot-tall (2.4 m), hideously ugly creation, with translucent yellowish skin pulled so taut over the body that it barely disguised the workings of the arteries and muscles underneath; watery, glowing eyes, flowing black hair, black lips, and prominent white teeth. The monster attempts to integrate himself into human society, but is shunned by all who see him. This compels him to seek revenge against his creator. A picture of the creature appeared in the 1831 edition. Early stage portrayals dressed him in a toga, shaded, along with the monsters skin, a pale blue. Throughout the 19th century, the monsters image remained variable according to the artist.. The best-known image of Frankensteins monster in popular culture derives from Boris Karloffs portrayal in the 1931 movie Frankenstein, in which he wore makeup applied, and according to a format designed by, Jack P. Pierce and possibly suggested by director James Whale. Universal Studios, which ...
In mid-July, Rolling Stone published on their website the article Best Monster Movies of All Time by Alexis Murphy and Julian Ring. At the very least, the list generated some . . . minor discussion on various message boards and forums. What movies were missed? What shouldnt have been on the list? Why exactly is Swamp Thing on there? In Part One of Monster Kid Radios reaction to this list, Derek looks at the twenty films that made Rolling Stones list, agreeing with some of the picks, but disagreeing with others.. Paul McComas - http://paulmccomas.com. The opening and closing song We are the Defenders of Atlantis! (from the album Atlantis EP) appears with permission of Monsters from Mars - http://monstersfrommars.com/. ...
Off Mystery Cove, Monster Rallys new album. Out on 11/11/16, available as a limited edition 12″ here.. When the beach party film revival arrives, Ted Feighan (aka Monster Rally) will be the Ennio Morricone of its resurgence. Mystery Cove, the forthcoming Monster Rally album, is a soundtrack to an imaginary movie both fit for the vaults of TMC and primed for a grindhouse exploitation flick screening. Mystery Cove contains a narrative arc of young lovers on an island getaway. As the grooves spin, Monster Rally reveals a cabalistic presence in the jungle that leads them on an adventure of surf competitions (The Big Surf), voodoo terror (Tourismo), and plenty of slushy cocktails (After Hours). The occult meets the salt-rimmed rum mix on Mystery Cove.. Since his Coral LP, Monster Rally has been an analog to the exotica forefathers. His reinvention of cocktail music via luau-loops and tchotchke breaks evokes a mondo vision of the subgenre. With Mystery Cove, the quiet village is not what it ...
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About Costume Shop Monster Child Costume [Animals and Insects] - Run and hide!Your little monster will be hideous and produce fear by its terrifying appearance in the Monster Child Costume. This freak of nature disguise includes a button down monster onesie jumpsuit with an attached monster head hood and tail. Available in Child Sizes: 2T-6. Includes: Jumpsuit. Product Page
Monster of Montauk The Montauk Monster washed up onshore of a New York beach in Montauk, Long Island. Several onlookers took pictures of it, sending it via e-mail on Wednesday.. According to Newsday, Alanna Navitski, an employee for Los Angeles Evolutionary Media Group, was behind the media frenzy. Navitski sent the picture of the monster to Anna Holmes, the managing editor at Jezebel, who then sent it to Gawker.. Gawker published the photo with the headline Dead Monster Washes Ashore in Montauk.. Many believe that it is a sea turtle without a shell or the remnants of a government animal-testing facility nearby. However, no scientific specialist has yet to identify what animal or creature this Montauk Monster truly is. And, the fact that the picture itself is real, and not one more falsification, should be still proven. In the age of digital photography and slick graphic artists, it is so easy to make us believe in something that is not exactly a reality.. Additional ...
Monster Energy Blend: glucose, taurine, panax ginseng extract, caffeine, glucuronolactone, guarana extract, inositol, l-carnitine, maltodextrin. Caffeine from All Sources: 100 mg per 8 fl oz serving (188 mg per can). No foam, extra hot, half-caf, no-whip, soy latte - Enough of the coffeehouse BS already! Its time to get out of the line and step up to whats next! Java Monster - premium coffee and cream brewed up with killer flavor, supercharged with Monster energy blend. Coffee done the Monster way, wide open, with a take no prisoners attitude and the experience and know-how to back it up. www.monsterenergy.com. Facebook. Instagram. Twitter. YouTube ...
Mom (Debra McGrath): The mother of the seven monsters, she is a kindly, babushka-wearing witch. Games Movies TV Video. He asks the magic Plooky to make everything backwards so they dont have to go to bed. High Noon is the 28th episode of Seven Little Monsters. blog . Revealed in The Winning Streak, she happens to be the second best bowler in Centerville under the nickname 10-pin Mom.Mama has an eastern European accent, and many people have placed her as being of Russian dissent. One, Two, Four, and Seven were playing a simplified version of volleyball without a net, since their backyard net had recently been damaged in a monster-related mishap. Binge Mimi Kennedys Favorite Mom Season 7 Episodes . Create New Account. Seven Little Monsters was a book by Maurice Sendak (of Where the Wild Things Are fame) that got a Animated Adaptation about a family of seven monsters and their mother. Pages Interest Mama of Little Monsters Videos Hes has been chosen among more than 2,800 other nominees to ...
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Directed by Paul W.S. Anderson (Resident Evil, Mortal Kombat), Monster Hunter looks like a mashup of Mad Max: Fury Road, Resident Evil, and a touch of various Godzilla creatures in the monsters designs. It also looks like quite the departure from the Capcom series, which allowed players to roam around an open world and fight monsters in slow, carefully paced battles.. Based on the trailer, I also wouldnt prepare for any kind of stellar dialogue writing - but I do like that were at a point where were referencing random Marvel Cinematic Universe movies (in this case, Guardians of the Galaxy).. Monster Hunter is scheduled to hit theaters this December, but just like nearly every movie this year, the film could be delayed. ...
Is there a part of you that somewhere, deep inside, believe that youre actually a…MONSTER? And how much energy have you been spending hiding that from the world? Here is the question: What if you ARE a monster - a monster of magic? What if that monster you are so afraid of being and exposing, is the most beautiful, gentle, kind, caring, potent invitation to a greater possibility that this world has ever seen? Most of us judge and hide the thing that is so beautiful about us, the thing that would change this world for the greater, because its totally inconceivable to this reality. Where could you be, if you gave up hiding? What could be unleashed if the secrets no longer had to be protected? Who would come out if you tore down the wall you put up to protect the world from you? What if all that energy youre spending hiding your monster is what is actually required to create the world youve always hoped for could come into existence? Youre invited to become the walking, talking, soaring ...
Capcom has released a graphic with the Monster Hunter World: Iceborne update roadmap for the first half of 2020, through May, with detailed information on January through April. Notably, the PC version of Iceborne will be synchronized with the console version in April—-both versions will have the same content. The PC Game will get large angry ape Rajang and the Volcanic Region in February. In March, it will get Stygian Zinogre, Safi’jiiva, and the Tundra Region. In April, to achieve parity with consoles, it will get two unannounced variant monsters, new Arch-Tempered and Master Rank versions of existing monsters, and the Astera/Seliana Fest. Despite bugs and setbacks, it seems that Capcom is still determined to provide ongoing support for Iceborne on the same level as the console versions received. There’s also a teaser here, for a “fan-favorite” monster in May—which could literally be anything because there’s someone who stans every single monster in the
Capcom has released a graphic with the Monster Hunter World: Iceborne update roadmap for the first half of 2020, through May, with detailed information on January through April. Notably, the PC version of Iceborne will be synchronized with the console version in April—-both versions will have the same content. The PC Game will get large angry ape Rajang and the Volcanic Region in February. In March, it will get Stygian Zinogre, Safi’jiiva, and the Tundra Region. In April, to achieve parity with consoles, it will get two unannounced variant monsters, new Arch-Tempered and Master Rank versions of existing monsters, and the Astera/Seliana Fest. Despite bugs and setbacks, it seems that Capcom is still determined to provide ongoing support for Iceborne on the same level as the console versions received. There’s also a teaser here, for a “fan-favorite” monster in May—which could literally be anything because there’s someone who stans every single monster in the
Even Nicoles ornaments have been taken over by monsters. You see…monsters have a fondness for shiny and colorful objects so it makes sense that my monsters have begun to claim Christmas ornaments as their own, she explains.. Visit her blog for ramblings on life with monsters and her Flickr site for more pix. Have a humorous weekend and make peace with your monsters.. ...
Well, like I said, the mini movies are just plain shi-tty. They look like somebody got 20 homies together and thought up little scenes to shoot, like some fools rollin by dumpin on a funeral. I think they were completely wortheless. But the parts with monster were pretty tight. I had seen him interviewed a few times on TV mostly when he was locked up and on the black power prison shi-. But this was him just being a banger. Hes rolling in the car with a camera man and sees some fool walking lookin like a banger with cornrows. Monsters like watch this and has them stop and he hops out. He hits the fool up and dude tells him his name is Kaos and acts like hes all hard for a second. Monsters like Monsta Kody, eight tray gangsta and this fool damn near wets his self and starts back trackin like nah, well, kaos is just sort of what i call myself, and uh I dont really bang or get down like that. Monster starts just clownin his ass. Then he just sits around smokin weed talkin bout shootin ...
Five people may have died in the past three years after drinking Monster Energy, according to reports released by the FDA. The reports do not prove a link between Monster Energy and the deaths or health problems. The mother of a 14-year-old Maryland girl who died from a heart arrhythmia after drinking Monster Energy on two consecutive days sued the company. A spokeswoman for Monster Beverage said last week that its products were safe and not the cause of the girls death.
The Movie Monster Game is an arcade game by Epyx from 1986. The player can haunt a town of his choice with a movie monster and fulfill a previously chosen mission there, e.g. destroy a sight, rescue your abducted young or simply destroy everything. Police, tanks, jets and other opponents give him a hard time. Tear down houses with your mere fists! Swallow tanks in one piece! Give Big Ben one on its bells or bend the Eiffel Tower: dreams as old as manhood itself. Already in 1983 did Epyx attend to this basic need of human existence and produced a game with the promising title Crush, Crumble & Chomp, which was about destroying as much as possible as a movie monster. In 1986 the game -at that time written in Basic - was found to be not en vogue enough any more and decided to release an improved version: The Movie Monster Game. They even invested in a licence to be allowed to use the name of the Japanese national hero Godzilla. The game starts with the options screen presenting itself as the outer ...
We have monsters and monster sightings all over the world, take the yeti, the big foot or the kraken, we all love the stories and the mystery behind them- are they there or not, who knows but one place where there is no shortage of such tales is the United States of America. While monster stories and sitting throughout the world have reached a handsome number, the USA is always a couple of steps ahead, and here is a great infographic that has all its monsters listed. They come in all shapes and sizes, prehistoric, bipeds, humanoid some are even cross between two or more animals.. ...
Code Monster uses a programming language that is also used by professionals namely JavaScript. This language is used in website design. Code Monster is from Crunchzilla and offers four different tutoring programs. Code Monster and Code Maven are similar. Code Monster is suitable for age 10-15. Use at a younger age is possible but will…
Monster Jam - Orlando 2008 - Grave Digger Freestyle Monster Jam is the worlds largest and most famous monster truck tour featuring the biggest names in mons...
Monster is your source for jobs and career opportunities. Search for jobs, read career advice from Monsters job experts, and find hiring and recruiting advice.
You dont have to visit a laboratory to become a monster with our Monster Stitch Knee-High Socks! Monster Knee-High Socks are green with black monster stitches details.
Cookie Monster sings Share It Maybe. Alistair Cookie: Frank Oz: Played by Cookie Monster, he is a parody of British broadcaster Alistair Cooke and appears in the Monsterpiece Theater sketch (a parody of Masterpiece Theater). Lets call it a day, it wont get better than this, wrote Jeff. 05:15 Sesame Street: When Cookie Met Sally (When Harry Met Sally Parody) 321 Views. Related Videos. SHOW COMMENTS (0) Why Is This One Of Your Favorites? Beyond television, the Workshop produces content for multiple media platforms on a wide range of issues including literacy and numeracy, emotional wellbeing, health and wellness, and respect and understanding. Earlier this month, Sesame Street also parodied Game of Thrones. Shipping and handling. Cookies Crumby Pictures (also known as Crumby Pictures Presents ) is a recurring Sesame Street segment starring Cookie Monster that debuted in the 44th season. Did you scroll all this way to get facts about cookie monster party? Sesame Street: Cookie of Oz ...
Monster Beverages first-quarter results made last quarters poor performance look like a one-time aberration. Adjusted net sales jumped almost 16% to $680.2 million, doubling the pace of last quarters growth and easily topping the 12% growth rate that most investors were hoping to see. Adjusted net income performed even better, jumping by almost half to $166.1 million. That produced adjusted earnings of $0.80 per share, compared to the $0.74 per share consensus forecast among investors.. Looking more closely at Monsters figures, some of the same trends weve seen in past quarters continued. Currency-related issues once again hit Monsters results, but to a lesser extent than weve seen in recent reports. The company said that net sales took a $12.3 million hit, or less than two percentage points, because of the strong dollar. Overall, net sales to customers outside the U.S. rose at a much faster pace than domestic sales, jumping 32% and making up more than a fifth of Monsters total ...
Monster Clay Premium Grade Modeling Clay is a re-useable sulfur free, professional oil/wax based sculpting medium. Composed entirely of non-toxic, food grade components, Monster Clay has an ultra smooth formulation that features a low melt temperature and a low tack feel that will not stick to tools or fingers. Monster
Foetus-in-foetu is a rare malformation in which a monozygotic diamniotic parasitic twin is incorporated into the body of its fellow twin and grows inside it. Less than 100 cases have been reported in literature. One day old newborn male was admitted with antenatal diagnosis of abdominal mass. It was cystic/solid in nature with pressure effects on left ureter and urinary bladder, most likely to be a germ cell tumour. Birth history was uneventful. Exploratory laparotomy was performed and the mass was excised. Physical examination confirmed the diagnosis of foetus-in-foetu. Although it is a rare condition, imaging may play an important role in the correct prospective diagnosis of foetus-in-foetu. Surgical excision is the recommended treatment.
Gareth B. Matthews John liked to draw monsters - all kinds of monsters. Some of them looked like puddings with teeth. Some had hundreds of eyes, and odd numbers of ears. Some were funny, some were scaly, some were green, some, purple. But all, all of them were violent. Johns monsters breathed smoke and fire, […]
Who wants to play? wonders Little Puppy. Everyone is either too busy, too lazy, too mean, or too boring. Then Little Puppy spies Big Green Monster reading on a bench. I will play with him! he declares. Big Green Monster has no interest in playing games or being friends with Little Puppy. He escapes to the peace and quiet of his bathtub. But when Little Puppy follows him home and takes a scary tumble, Big Green Monster immediately comes to the rescue-and finds that there might just be a place for this tiny dog in his giant heart.. ...
The monster in Conors backyard is not the one hes been expecting - the one from the nightmare hes had every night since his mother started her treatments. This monster is ancient. And wild. And it wants something from Conor. It wants the truth. From the final idea of award-winning author Siobhan Dowd-whose premature death from cancer prevented her from writing it herself-Patrick Ness has spun a haunting and darkly funny novel of mischief, loss, and monsters both real and imagined. This paperback movie tie-in edition includes a book group discussion guide ...
Monster Island is a Womens Racerback Tank from our trendy graphic pop culture collection of custom fandom inspired products and t shirt. Artist is AustinJames and design is: Godzilla,movie,monster,kaiju,king of the monsters,text,summer,vacation,travel
div class=grab-button style=width: 100px; margin: 0 auto;> ,a href=http://www.bentomonsters.com/ rel=nofollow> ,img src=http://4.bp.blogspot.com/-G8BvwjVKwaU/VdIrnKA2uyI/AAAAAAAACZM/pJXt8FSD8b0/s1600/Bento%2BMonsters_Buttons.png alt=Bento Monsters title=Bento Monsters width=100 height=100 /> ,/a> ,/div ...
Read all the chapters of A Monster Who Levels Up Novel. We have compiled all the chapters of A Monster Who Levels Up so that you can read all of them without any hassle
My co-collaborators on this project and I have often discussed doing a monster card set of some kind over the past several years ( of our association working on a certain notorious non-sports card franchise) and we finally took the plunge- having no idea really what to expect . Ive always maintained monsters are beloved and monster cards most of all , but we hadnt thought to incorporate pin-up art into the equation. Thus CREEPING FLESH was born ( or raised ...
Fluorescent in situ hybridization may be able to help locate a mutation or abnormality that may be allowing tumor growth. This ... The use of radiation has been limited in children younger than three because of the risk of severe neurocognitive deficits. ... Atypical teratoid rhabdoid tumor is rare, and no therapy has been proven to deliver long-term survival, nor a set of protocols ... An atypical teratoid rhabdoid tumor (AT/RT) is a rare tumor usually diagnosed in childhood. Although usually a brain tumor, AT/ ...
... malignant M9502/0 Teratoid medulloepithelioma, benign M9502/3 Teratoid medulloepithelioma M9503/3 Neuroepithelioma, NOS M9504/3 ... CIN III with severe dysplasia (C53._) Vaginal intraepithelial neoplasia, grade III (C52._) VAIN III (C52._) Vulvar ... abnormalities AML, MLL M9910/3 Acute megakaryoblastic leukemia, NOS Megakaryocytic leukemia (FAB-M7) M9920/3 Acute myeloid ... chromosome abnormality M9989/3 Myelodysplastic syndrome, NOS Medical classification International Classification of Diseases ...
progressive dementia or stupor in patients with a nonfocal neurologic exam and minimal abnormalities on MRI (more common in ... is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS). ...
Atypia: an indication of abnormality of a cell (which may be indicative for malignancy). Significance of the abnormality is ... Less commonly, and seen usually in infants, are teratomas and atypical teratoid rhabdoid tumors.[66] Germ cell tumors, ... Grade I tumors are the least severe and commonly associated with long term survival, with severity and prognosis worsening as ... or more severe symptoms such as tremors, paralysis on one side of the body hemiplegia, or (epileptic) seizures in a patient ...
Atypia: an indication of abnormality of a cell (which may be indicative for malignancy). Significance of the abnormality is ... Less commonly, and seen usually in infants, are teratomas and atypical teratoid rhabdoid tumors.[65] Germ cell tumors, ... or more severe symptoms such as tremors, paralysis on one side of the body hemiplegia, or (epileptic) seizures in a patient ...
Congenital Abnormalities. Abnormalities, Severe Teratoid. Folic Acid. Vitamin B Complex. Hematinics. Vitamins. Micronutrients. ...
Abnormalities, Severe Teratoid. Congenital Abnormalities. To Top. *For Patients and Families. *For Researchers ...
Subjects: Abnormalities Abnormalities, Human Abnormalities, Severe Teratoid Animals Dwarfs Electronic books Giants Monsters ... Subjects: Abnormalities Abnormalities, Human Abnormalities, Severe Teratoid Animals Anthropology Electronic books Occultism ... Subjects: Abnormalities Abnormalities, Human Animals Causes and theories of causation Congenital Abnormalities Disease Diseases ... Subjects: Abnormalities Abnormalities, Human Animals Conjoined twins Early works Early works to 1800 Fetal presentation Human ...
Abnormalities, Severe Teratoid. Twins, Conjoined. 16. [Illuminated letter U] Publication:. Bethesda, MD : U.S. National Library ... Abnormalities, Severe Teratoid. 6. Polomie Publication:. Bethesda, MD : U.S. National Library of Medicine, National Institutes ...
Abnormalities, Severe Teratoid. 6. Polomie Publication:. Bethesda, MD : U.S. National Library of Medicine, National Institutes ...
C16 - Congenital, Hereditary, and Neonatal Diseases and Abnormalities. Monsters. Abnormalities, Severe Teratoid. ...
Abnormality, Severe Teratoid Severe Teratoid Abnormalities Severe Teratoid Abnormality Teratoid Abnormalities, Severe Teratoid ... Severe Teratoid Abnormalities. Severe Teratoid Abnormality. Teratoid Abnormalities, Severe. Teratoid Abnormality, Severe. ... Abnormalities, Severe Teratoid - Preferred Concept UI. M0014046. Scope note. Marked developmental anomalies of a fetus or ... Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Congenital, Hereditary, and Neonatal Diseases and ...
Abnormalities, Drug-Induced. *Abnormalities, Multiple. *Abnormalities, Radiation-Induced. *Abnormalities, Severe Teratoid. * ... "Musculoskeletal Abnormalities" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... IHH Gene Mutations Causing Short Stature With Nonspecific Skeletal Abnormalities and Response to Growth Hormone Therapy. J Clin ... This graph shows the total number of publications written about "Musculoskeletal Abnormalities" by people in Harvard Catalyst ...
Abnormalities, Radiation-Induced (0) * Abnormalities, Severe Teratoid (0) * Aicardi Syndrome (0) * Cardiovascular Abnormalities ... Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) * Congenital Abnormalities (3) * Abnormalities, Drug- ... in Abnormalities, Multiple by mythara My 4yr old daughter was diagnoised w/ Partial Facial Paralysis and now has been found to ...
Teratoid (severe)O. Teratoid (moderate)P. Normal spermatozoa. Male factor infertility may result from low sperm count or low ... The treatment is completely free of any side effects.Medicine is effective in 95% in sperm abnormalities i.e. Low Sperm count, ... Cells exposed to significant levels of radiation may take up to two years to resume normal sperm production, and, in severe ... A.Normal Sperm B. Knobbed acrosome (beaded form)C. Pyriform head (severe)D. Pyriform head (moderate)E. Pyriform head (slight)F ...
Abnormalities, Drug-Induced. *Abnormalities, Multiple. *Abnormalities, Radiation-Induced. *Abnormalities, Severe Teratoid. * ... "Musculoskeletal Abnormalities" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Musculoskeletal Abnormalities" by people in this website by ... Below are the most recent publications written about "Musculoskeletal Abnormalities" by people in Profiles. ...
Severe Teratoid., Sexually Transmitted Diseases., Exhibits as Topic., Museums., Anatomy.) ... Liverpool Museum of Anatomy (Sexually transmitted diseases., Monsters., Masturbation., Anatomical museums., Abnormalities, ... Abnormalities, Severe Teratoid. *Sexually Transmitted Diseases. *Exhibits as Topic. *Museums. *Anatomy. Genre. *Electronic ...
Newly diagnosed atypical teratoid rhabdoid tumors (ATRTs) with or without tumors affecting other areas outside the brain and ... Other severe acute or chronic medical or psychiatric condition, including uncontrolled diabetes, malabsorption, resection of ... or electrocardiographic evidence of acute ischemia or active conduction system abnormalities (if for some reason an ... When an MRT originates in the brain or spinal cord, it is usually called an atypical teratoid rhabdoid tumor (ATRT). ...
ATYPICAL TERATOID/RHABDOID TUMOR OF THE CENTRAL NERVOUS SYSTEM : The patient is a four year old Caucasian girl with a ... MYOPATHY WITH CYTOPLASMIC BODIES AND MULTI-CORES. A 32-year-old woman with anorexia nervosa and depression developed severe ... constitutional ring chromosome 22 abnormality.. * PILOCYTIC ASTROCYTOMA: This 22 month old white female presented with an 8 ... week prior presented with mental status changes and a severe occipital headache of two days duration. ...
... an abnormality in the production of beta chains which causes the red cells to more easily breakdown resulting in mild to severe ... Atypical Teratoid Rhabdoid Tumor. An atypical teratoid rhabdoid tumor, is a fairly rare aggressive tumor usually diagnosed in ... Severe Combined Immune Deficiency. Severe combined immune deficiency is a rare genetic birth defect that doesnt allow the body ... Alpha thalassemia is an abnormality in the production of alpha chains which causes the red cells to more easily breakdown. ...
Severe combined immunodeficiency. 1 , 51 Severe congenital neutropenia. 1 , 12 THYMUS ABNORMALITY. 1 , 3 ... atypical teratoid / rhabdoid tumor. 1 , 5,112 ear infection chronic. 1 , 52 ependymoma. 1 , 4,679 ...
A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination MAMMALIAN GENOME Noveroske, J. K., Hardy, R., Dapper ... Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to ... and atypical teratoid rhabdoid tumor (ATRT). Seventeen patients received LC (2 mg/kg up to 50 mg, every 2 weeks to monthly) at ... Here we report on a patient who presented at 7 years of age with loss of consciousness and severe metabolic acidosis following ...
A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination MAMMALIAN GENOME Noveroske, J. K., Hardy, R., Dapper ... Biochemical abnormalities seen in some MMA patients, such as lactic acidemia and increased tricarboxylic acid cycle ... and atypical teratoid rhabdoid tumor (ATRT). Seventeen patients received LC (2 mg/kg up to 50 mg, every 2 weeks to monthly) at ... Here we report on a patient who presented at 7 years of age with loss of consciousness and severe metabolic acidosis following ...
Abnormalities, Drug-Induced. Abnormalities, Multiple. Abnormalities, Radiation-Induced. Abnormalities, Severe Teratoid. ... Eye Abnormalities. Eye Diseases, Hereditary. F. Fabry Disease. Factor V Deficiency. Factor VII Deficiency. Factor X Deficiency ... Stomatognathic System Abnormalities. Sulfatidosis. Syndactyly. Synostosis. Syphilis, Congenital. T. Tangier Disease. Tay-Sachs ... Skin Abnormalities. Skin Diseases, Genetic. Smith-Lemli-Opitz Syndrome. Smith-Magenis Syndrome. Sotos Syndrome. Spastic ...
Animals, Laboratory , Teratogens , Ethanol , Mass Screening , Abnormalities, Severe Teratoid/prevention & control 4. ... Animals, Laboratory , Vitamin E , Craniofacial Abnormalities/prevention & control , Chick Embryo , Congenital Abnormalities/ ... Out of all birth defects, congenital abnormalities of the heart are at the top. There are many etiological factors responsible ... Apart from craniofacial and brain defects this syndrome produces various cardiac abnormalities such as atrial and ventricular ...
Abnormality, Respiratory System use Respiratory System Abnormalities Abnormality, Severe Teratoid use Abnormalities, Severe ... Abnormalities, Nervous System use Nervous System Malformations Abnormalities, Radiation Induced use Abnormalities, Radiation- ... Abnormality, Nervous System use Nervous System Malformations Abnormality, Radiation-Induced use Abnormalities, Radiation- ... Abnormalities, Congenital use Congenital Abnormalities Abnormalities, Congenital, Nervous System use Nervous System ...
Abnormality, Respiratory System use Respiratory System Abnormalities Abnormality, Severe Teratoid use Abnormalities, Severe ... Abnormalities, Nervous System use Nervous System Malformations Abnormalities, Radiation Induced use Abnormalities, Radiation- ... Abnormality, Nervous System use Nervous System Malformations Abnormality, Radiation-Induced use Abnormalities, Radiation- ... Abnormalities, Congenital use Congenital Abnormalities Abnormalities, Congenital, Nervous System use Nervous System ...
Abnormality, Respiratory System use Respiratory System Abnormalities Abnormality, Severe Teratoid use Abnormalities, Severe ... Abnormalities, Nervous System use Nervous System Malformations Abnormalities, Radiation Induced use Abnormalities, Radiation- ... Abnormality, Nervous System use Nervous System Malformations Abnormality, Radiation-Induced use Abnormalities, Radiation- ... Abnormalities, Congenital use Congenital Abnormalities Abnormalities, Congenital, Nervous System use Nervous System ...
Abnormality, Respiratory System use Respiratory System Abnormalities Abnormality, Severe Teratoid use Abnormalities, Severe ... Abnormalities, Nervous System use Nervous System Malformations Abnormalities, Radiation Induced use Abnormalities, Radiation- ... Abnormality, Nervous System use Nervous System Malformations Abnormality, Radiation-Induced use Abnormalities, Radiation- ... Abnormalities, Congenital use Congenital Abnormalities Abnormalities, Congenital, Nervous System use Nervous System ...
Fluorescent in situ hybridization may be able to help locate a mutation or abnormality that may be allowing tumor growth. This ... The use of radiation has been limited in children younger than three because of the risk of severe neurocognitive deficits. ... Atypical teratoid rhabdoid tumor is rare, and no therapy has been proven to deliver long-term survival, nor a set of protocols ... An atypical teratoid rhabdoid tumor (AT/RT) is a rare tumor usually diagnosed in childhood. Although usually a brain tumor, AT/ ...
... malignant M9502/0 Teratoid medulloepithelioma, benign M9502/3 Teratoid medulloepithelioma M9503/3 Neuroepithelioma, NOS M9504/3 ... CIN III with severe dysplasia (C53._) Vaginal intraepithelial neoplasia, grade III (C52._) VAIN III (C52._) Vulvar ... abnormalities AML, MLL M9910/3 Acute megakaryoblastic leukemia, NOS Megakaryocytic leukemia (FAB-M7) M9920/3 Acute myeloid ... chromosome abnormality M9989/3 Myelodysplastic syndrome, NOS Medical classification International Classification of Diseases ...
  • Atypical teratoid/rhabdoid tumors are very rare, and absolute risk to siblings is not reported in the literature. (wikipedia.org)
  • Classically, tumors that arise in the central nervous system are referred to as atypical teratoid/rhabdoid tumors, whereas those arising in the kidney or other extracranial sites are referred to as malignant rhabdoid tumors. (mendelian.co)
  • Embryonal tumors often arise in children younger than 2 years of age, and in the past decade an increasing incidence of the atypical teratoid/rhabdoid tumor has been reported. (medlink.com)
  • Other brain tumors occurring in this age range, including medulloblastomas, choroid plexus tumors, lower grade neuro-glial tumors, and atypical teratoid tumors, are discussed in separate articles. (medlink.com)
  • We demonstrate the effect of a humanized anti-CD47 antibody, Hu5F9-G4, on five aggressive and etiologically distinct pediatric brain tumors: group 3 medulloblastoma (primary and metastatic), atypical teratoid rhabdoid tumor, primitive neuroectodermal tumor, pediatric glioblastoma, and diffuse intrinsic pontine glioma. (stanfordchildrens.org)
  • Congenital structural abnormalities and deformities of the musculoskeletal system. (harvard.edu)
  • Out of all birth defects, congenital abnormalities of the heart are at the top. (bvsalud.org)
  • The constellation of neuropathologic features (ventriculomegaly, mineralized neurons, and dystrophic calcification with band-like subcortical distribution) differs from features seen in other common infections associated with congenital abnormalities (e.g. (freethesaurus.com)
  • Congenital masses in the neck include branchial cleft cysts, thyroglossal duct cysts (TGDCs), ectopic thymus cysts, dermoid and teratoid cysts, cystic vascular abnormalities, and lymphatic malformations such as the cystic lymphangioma. (medscape.com)
  • Congenital myenteric hypoganglionosis is a rare developmental disorder characterized clinically by severe and persistent neonatal intestinal pseudoobstruction. (bvsalud.org)
  • Other more variable features may include poor overall growth, craniofacial abnormalities, spinal anomalies, and congenital heart defects (review by Vergano and Deardorff, 2014 ). (mendelian.co)
  • Description of the case, plausible explanations on the mechanisms of conjointment along with the associated congenital abnormalities of the deceased twin are examined along with an historical revision of craniopagus parasiticus and their separation attempts with special attention to the previously undocumented attempt of the Dominican CP separation surgery by Lazareff et al. (neurosurgery.directory)
  • Musculoskeletal Abnormalities" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Musculoskeletal Abnormalities" by people in Harvard Catalyst Profiles by year, and whether "Musculoskeletal Abnormalities" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Musculoskeletal Abnormalities" by people in Profiles. (harvard.edu)
  • An atypical teratoid rhabdoid tumor, is a fairly rare aggressive tumor usually diagnosed in young children that forms in the tissues of the Central Nervous System. (nicklauschildrens.org)
  • An atypical teratoid rhabdoid tumor (AT/RT) is a rare tumor usually diagnosed in childhood. (wikipedia.org)
  • Synchronous Central Nervous System Atypical Teratoid/ Rhabdoid Tumor and Malignant Rhabdoid Tumor of the Kidney: Case report of a Long-Term Survivor and Review of the Literature. (uah.edu)
  • BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) with synchronous or metachronous extra-CNS disease is a rare childhood malignancy with a dismal prognosis. (uah.edu)
  • Teratoma or teratoblastoma , also called teratoid tumor - this was the first explanation suggested in the show for the boy's condition. (everything2.com)
  • If the growth inside Alamjan were actually teratoid tumor, he must undergo treatment . (everything2.com)
  • A primary central nervous system lymphoma ( PCNSL ), also known as microglioma and primary brain lymphoma , [1] is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS ). (wikipedia.org)
  • I specialize in the treatment of pediatric craniofacial abnormalities, spinal disorders, sports-related injuries and trauma to the brain and spine. (childrenshospital.org)
  • I am committed to improving the lives of patients with craniofacial abnormalities, spinal disorders and brain injury. (childrenshospital.org)
  • Lymphangioleiomyomatosis (LAM) is a multiple cystic lung disease characterized by progressive cystic destruction of the lung and lymphatic abnormalities, frequently associated with renal angiomyolipomas (AMLs). (mendelian.co)
  • Affected individuals can have a wide variety of signs and symptoms, but the most common are sparse scalp hair, small head size (microcephaly), distinct facial features, short stature, prominent finger joints, unusually short fingers and toes (brachydactyly), recurrent seizures (epilepsy), and moderate to severe intellectual disability with impaired language development. (malacards.org)
  • The number of second-line treatments and severe/recurrent infections were independently associated with mortality. (bvsalud.org)
  • The patient is a four year old Caucasian girl with a constitutional ring chromosome 22 abnormality. (yassermetwally.com)
  • Thangavelu M, Finn WG, Yelavarthi KK, Roenigk HH, Samuelson E, Peterson L, Kuzel TM, Rosen ST. Recurring structural chromosome abnormalities in peripheral blood lymphocytes of patients with mycosis fungoides/Sézary syndrome. (rush.edu)
  • Hemifacial microsomia can also be found in children with other chromosome abnormalities. (weillcornellbrainandspine.org)
  • All of these are demonstrated through the most often/important diseases/abnormalities of each organ, to give a good practical guideline for the referring physician. (bme.hu)
  • A 3.1-Mb microdeletion of 3p21.31 associated with cortical blindness, cleft lip, CNS abnormalities, and developmental delay. (ucdenver.edu)
  • This margin can change if developmental abnormality or locational variation is present. (bme.hu)
  • The precise cause is unclear, but this finding on fetal ultrasound is not associated with any structural or functional abnormality in the baby. (healthtap.com)
  • The aim of this study was to characterize and extensively evaluate long-term liver involvement in MMA and PA patients.We first describe four patients who had severe liver involvement during the course of their disease. (stanford.edu)
  • The diagnosis typically requires full-thickness intestinal biopsy as the abnormality is confined to the myenteric plexus in many patients. (bvsalud.org)
  • Patients with severe RHF requiring right ventricular assist device support had a low success of bridge to transplantation (11.1% vs 33.3%, p = 0.02). (uah.edu)
  • Almost everyone with Nicolaides-Baraitser syndrome has moderate to severe intellectual disability. (malacards.org)
  • The anatomic location of a branchial cleft abnormality represents the presumed branchial cleft of origin. (medscape.com)
  • They mainly occur in the ventricles and mostly present with severe hydrocephalus. (springer.com)
  • other blood vessel abnormalities that may occur in this disorder include constriction (stenosis) and abnormal bulging (aneurysm) of vessels, as well as small clusters of enlarged blood vessels just under the skin (telangiectasia). (malacards.org)
  • in moderate to severe cases the condition creates more significant deformities of the ears, mouth, and jaw. (weillcornellbrainandspine.org)
  • Auditory neuropathy was diagnosed based on abnormal auditory evoked potentials with neural components suggesting severe to profound hearing loss in the presence of cochlear microphonic responses and behavioral reactions to sound at mild to moderate hearing levels. (saladgaffe.ga)
  • Probably for technical reasons, cytogenetic abnormalities appear to be less frequent in CLL than in many other hematological malignancies although the use of techniques such as in situ hybridization, comparative genomic hybridization, and others has significantly increased the proportion of cases with cytogenetic abnormalities (16). (clicktocurecancer.info)
  • A 32 year old man with symptoms of an upper respiratory infection one week prior presented with mental status changes and a severe occipital headache of two days duration. (yassermetwally.com)
  • In severe cases, there is no evidence for the optimal therapeutic strategy. (bvsalud.org)
  • No abnormalities in routine blood workup. (springeropen.com)
  • it is characterized by blood vessel abnormalities, particularly abnormal twists and turns (tortuosity) of the blood vessels that carry blood from the heart to the rest of the body (the arteries). (malacards.org)
  • What many people have is an Epipen ( epinephrine ) which allows people with severe allergies to give themselves a dose of Epinephrine and stop or limit a severe allergic reaction . (healthtap.com)