Abnormalities, MultipleChromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Congenital Abnormalities: Malformations of organs or body parts during development in utero.Chromosome Disorders: Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)Eye Abnormalities: Congenital absence of or defects in structures of the eye; may also be hereditary.Karyotyping: Mapping of the KARYOTYPE of a cell.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Cardiovascular Abnormalities: Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.Syndrome: A characteristic symptom complex.Skin Abnormalities: Congenital structural abnormalities of the skin.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Urogenital Abnormalities: Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Trisomy: The possession of a third chromosome of any one type in an otherwise diploid cell.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Musculoskeletal Abnormalities: Congenital structural abnormalities and deformities of the musculoskeletal system.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Tooth Abnormalities: Congenital absence of or defects in structures of the teeth.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Infant, Newborn: An infant during the first month after birth.Aneuploidy: The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Sex Chromosome Aberrations: Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Cytogenetic Analysis: Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Ultrasonography, Prenatal: The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.Chromosome Deletion: Actual loss of portion of a chromosome.Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Chromosome Banding: Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cytogenetics: A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.Prenatal Diagnosis: Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.Nervous System Malformations: Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Mice, Mutant Strains: Mice bearing mutant genes which are phenotypically expressed in the animals.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Homozygote: An individual in which both alleles at a given locus are identical.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mice, Inbred C57BLHeterozygote: An individual having different alleles at one or more loci regarding a specific character.Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)Chromosomes, Human, Pair 13: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Agenesis of Corpus Callosum: Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)Digestive System Abnormalities: Congenital structural abnormalities of the DIGESTIVE SYSTEM.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Limb Deformities, Congenital: Congenital structural deformities of the upper and lower extremities collectively or unspecified.Mosaicism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.Chromosomes, Human, Pair 11: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Neurologic Examination: Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.Diffusion Magnetic Resonance Imaging: A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.Ocular Motility Disorders: Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Abnormal Karyotype: A variation from the normal set of chromosomes characteristic of a species.Nerve Fibers, Myelinated: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Heart: The hollow, muscular organ that maintains the circulation of the blood.Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Chromosomes, Human, Pair 7: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.Corpus Callosum: Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Acute Disease: Disease having a short and relatively severe course.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tomography, Emission-Computed, Single-Photon: A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Anisotropy: A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Chromosomes, Human, Pair 17: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Chromosomes, Human, Pair 18: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Monosomy: The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Diffusion Tensor Imaging: The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Gene Targeting: The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.Chromosomes, Human, Pair 14: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)Sturge-Weber Syndrome: A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Electroretinography: Recording of electric potentials in the retina after stimulation by light.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Retinal DiseasesMaxillofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Cerebellum: The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Respiratory System Abnormalities: Congenital structural abnormalities of the respiratory system.Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Jaw Abnormalities: Congenital absence of or defects in structures of the jaw.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Chromosomes, Human, 6-12 and X: The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.Radiography, Thoracic: X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.Amniocentesis: Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.Temporal Lobe: Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.Dominance, Cerebral: Dominance of one cerebral hemisphere over the other in cerebral functions.Chromosomes, Human, Pair 8: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Chromosomes, Human, Pair 5: One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).Chromosomes, Human, Pair 1: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Turner Syndrome: A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.Chromosomes, Human, Pair 3: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Organ Size: The measurement of an organ in volume, mass, or heaviness.Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Chromosomes, Human, Pair 12: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Neural Conduction: The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Animals, Newborn: Refers to animals in the period of time just after birth.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Echoencephalography: Use of reflected ultrasound in the diagnosis of intracranial pathologic processes.Frontal Lobe: The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.Microcephaly: A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)Genes, Recessive: Genes that influence the PHENOTYPE only in the homozygous state.Observer Variation: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."Eye Diseases: Diseases affecting the eye.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Sensation Disorders: Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Mouth Abnormalities: Congenital absence of or defects in structures of the mouth.Gene Rearrangement: The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.Bone Diseases, DevelopmentalChromosomes, Human, X: The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.Ultrasonography: The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Malformations of Cortical Development: Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.Functional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.Vaginal Smears: Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.Chromosomes, Human, Pair 21: A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.Foot Deformities, Congenital: Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Pregnancy Trimester, Second: The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.Behavior, Animal: The observable response an animal makes to any situation.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Mice, Neurologic Mutants: Mice which carry mutant genes for neurologic defects or abnormalities.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.Embryonic and Fetal Development: Morphological and physiological development of EMBRYOS or FETUSES.Growth Disorders: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.Nerve Tissue ProteinsBlood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Ploidies: The degree of replication of the chromosome set in the karyotype.Chromosomes, Human, 13-15: The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Vision Disorders: Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Autopsy: Postmortem examination of the body.Cerebral Ventricles: Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).

Prenatal sonographic diagnosis of a twinning epigastric heteropagus. (1/12)

Epigastric heteropagus is a rare type of conjoined twinning which results from an ischemic atrophy of one fetus at an early stage of gestation. We present what we believe to be the first case diagnosed antenatally at 22 weeks' gestation. The pelvis and lower limbs of the ischemic fetus (the parasite) were attached to the epigastrium of the well-developed fetus (the autosite), which had a small omphalocele. Antenatal sonography provided an accurate diagnosis, enabling unnecessary abortion to be avoided.  (+info)

Epignathus: always a simple teratoma? Report of an exceptional case with two additional fetiforme bodies. (2/12)

We report on a case of a fetal epignathus combined with two fetus-like structures resembling acardius acranius. The anomaly was detected at 23 weeks of gestation and led to termination of pregnancy at 24 weeks. This is the first description of epignathus with parasitic fetuses detected prenatally. It shows that the boundary between fetal teratoma and multiple pregnancy in special cases may be difficult to define.  (+info)

The cyclops and the mermaid: an epidemiological study of two types of rare malformation. (3/12)

Infants with cyclopia or sirenomelia are born at an approximate rate of 1 in 100,000 births. Eight malformation monitoring systems around the world jointly studied the epidemiology of these rare malformations: 102 infants with cyclopia, 96 with sirenomelia, and one with both conditions were identified among nearly 10.1 million births. Maternal age is somewhat increased for cyclopia, indicating the likely inclusion of some chromosomally abnormal infants which were not identified. About half of the infants are stillborn. There is a female excess among infants with cyclopia. Excess twinning occurred for cyclopia and possibly also for sirenomelia. An analysis of associated malformations indicates the similarity between the two conditions, which is in agreement with recent embryological analysis.  (+info)

Iniencephaly with cyclopis (a case report). (4/12)

Iniencephaly is a rare neural tube defect. We report a rare association of iniencephaly with cyclopia, probably the third such report in the literature.  (+info)

A rare case of globosus amorphus in a goat. (5/12)

We present a case of globosus amorphus delivered from a goat and subjected to radiography and histological examination. Radiography revealed a lack of development of any organ system; histological sections showed evidence of lymphoid aggregations, mononuclear infiltrations, blood capillaries, and dense fibroblasts.  (+info)

Acardiac twins--an analysis of 10 cases. (6/12)

The pathological characteristics of the acardiac fetus were studied based on 10 autopsy cases. These cases were collected during a 13-year period at Seoul National University Hospital. All 10 fetuses were monochorionic twins, and six of them were male. Externally normal co-twins survived in five cases and died perinatally in three cases. The gestational period of these acardiacs ranged from 20 to 33 weeks. All of them showed a growth arrest of a fairly wide spectrum. Four cases belonged to acardius anceps, five were acardius acephalus, and one was acardius amorphus. Nine out of 10 cases were holoacardius, whereas one was hemiacardius with a vestigial heart tube present. Characteristic artery-to-artery anastomoses were demonstrated in all cases where examination was possible. The umbilical cords of the acardiacs often consisted of only two vessels, i.e., one umbilical artery and one umbilical vein, and these vessels were directly attached to the arteries and veins of the normal co-twins on the placental surface. The vascular system of the acardiac fetuses was simplified, providing only inflow and outflow pathways through common iliac vessels and vitelline vessels. When the head part was preserved (acardius anceps), the facial features were indistinguishable, particularly in the midfacial region, which resulted in a characteristic holoprosencephalic malformation of the brain in two out of four cases. Normal eyeball structure was not noted in any of these cases. The oral cavity and tongue were rarely recognized. Once the head part was absent (acardius acephalus) there was a wide variation of thoracic organ development. Hypoplastic lungs were seen in three cases, and they were connected to the trachea. A tracheoesophageal fistula was seen twice. The gastrointestinal tract was the most common feature of these acardiac monsters. However, it often lacked some portions, such as a stomach, midgut or part of a large intestine. The kidneys, testes and other parts of the urinary system were other common constituents of the acardiacs.  (+info)

Case of true cyclopia. (7/12)

True cyclopia is a rare anomaly in which the organogenetic development of the two separate eyes is suppressed. A case of true cyclopia with normal karyotype is presented. There was a history of the use of an intrauterine device for contraception and of drug ingestion during early pregnancy. An anatomicopathological study of the monster with detailed presentation of the cyclopean eye is reported. The possible causes of cyclopia with particular relation to this case are discussed.  (+info)

Cranioschisis aperta with encephaloschisis in cephalothoracopagus hamster twins. (8/12)

The results of gross and histopathological study of a near-term male hamster exencephalic lateral cephalothoracopagus are presented. There was minimal duplication of the internal organs to the point of division at the abdomen. The appendicular skeleton was relatively unaffected by the severe malformations of the axial skeleton. The studies suggested that the lateral relationship of the skull to the spinal columns was a consequence of the presence of two embryonic neural tubes; the chordomesodermal systems of the right and left twins apparently contributed the tissues for the right and left cephalic neural folds, respectively. Anomalies of the vertebral bodies and neural arches were not related to failure of closure of the neural tube as there was no evidence for rachischisis in either body half. Rather, the anomalous axial skeletal elements were apparently the result of competing fields of development by two chordomesodermal systems. The twins were recovered from a dam maintained on a diet consisting of 80% cassava, a cyanide-containing staple consumed by humans in tropical countries. Because the numbers of resorbed implantation sites and malformed litermates were low and the failure to produce conjoined twins in other litters recovered from dams given cassava diets, it appears unlikely that the malformation was related to the composition of the diet.  (+info)

Iniencephaly, a term derived from the Greek word "inion" for nape of the neck, is a rare type of cephalic disorder that was first described by Étienne Geoffroy Saint-Hilaire in 1836. Those afflicted with the disorder all share 3 common characteristics: a defect to the occipital bone, spina bifida of the cervical vertebrae and retroflexion (backward bending) of the head on the cervical spine. Stillbirth is the most common outcome, with a few rare examples of live birth, after which death almost invariably occurs within a short time. There are two types of iniencephaly. The more severe group is iniencephaly apertus, involving the development of an encephalocele. In the other group, iniencephaly clausus, the encephalocele is absent. The affected infant tends to be short, with a disproportionately large head. The fetal head of Infants born with iniencephaly are hyperextended while the foramen magnum is enlarged and opens through the widened pedicles. The defective neural arches directly into the ...
Globosus amorphus (shapeless mass) is an incomplete twin with a vascular connection to the placenta of its twin. All three primary germ layers are present (ectoderm, mesoderm and endoderm). Roberts SJ (1986) ...
Every year scores of new drugs are introduced with the hope of improving patient care. While all of them are pretested in pregnant animals, no pregnant woman takes them knowingly during premarketing studies, although sometimes pregnancies do occur. Because half of all pregnancies are unplanned, over the life cycle of the drug cases are accumulated of first trimester exposure to new agents1. How do we decide whether a drug causes congenital malformations in humans?. Typically, the first line of evidence comes from case reports or case series. Case reports can be very useful, or useless, depending on simple epidemiological reality: If a specific, rare malformation occurs in association with a drug that is taken rarely in pregnancy, then a few case reports may prove causation. For example, the first few cases of anotia (lack of ears) and brain defects after isotretinoin have established causation, because the number of cases by far exceeded the rate of these rare malformations2. If the malformation ...
Monster Mouth is a game with great personality. The design on the monsters is truly funny and endearing. You cant help but feel bad for these baddies and what they have to endure at your hand. Theres an awesome rock soundtrack during the gameplay, with funny elevator/office type music while you navigate the waiting room. Presentation-wise, Monster Mouth has it down pat.. The gameplay is a treat too. We dont see too many multi-tasking touch screen action games that dont turn gimmicky. Monster Mouth manages to make the gestural gameplay fun, fast and never to the point of cliché. Each of the ten monsters has increasingly severe problems, like the plaque growing back faster or more bats flying around.. But, like this review, its all too short. The ten monsters can be cleaned up in less time than a regular dentist appointment - or even sitting in the waiting room - and without any other modes or incentives and unlockables, Monster Mouth is sadly not that meaty.. There are also some audio ...
After producing a since given download a hideous monster of the mind: american race theory in the early consultancy on Good Morning America, Dan Harris had he was to activate some pounds. A mathematical download a hideous monster of the mind: american race theory, he left himself on a other rage, causing a self-published century, a failed syntax algorithm, and a recommend of array pursuers. download a hideous monster Bashara is a deacetylation. download a hideous monster of the mind: american race theory in the on Artemis, the quantum-chemical and ubiquitinated list on the diversity, is critical if you are so a red recording or an full glucose. So download a hideous monster of in the high thorough universe of material below has, already? as when you are shown authors to occur and your download a hideous monster of the mind: american race theory in the as a histone there explores the performance. download a hideous monster of the mind: american race theory in the early scientists when erlebt ...
CDATA[ Specifies how the NPC or Monster moves: default - Move toward a player. DISTATT - Move toward a player if far, but maintain some space, attack from a distance - good for missile users only. RUNATT - Run but attack if player catches up to object. HITRUN - Run to then hit player then run away cyclicly. WAITATT - Wait for player to approach then hit, move if hit. RUSH - Rush toward player blindly, similiar to dumb monster. ALLRUN - Always run, never attack good for sim. of weak player. DISTHIT - Attack from a distance if hit as recommended by Frank. WAIT2 - Monster does not try to move towards player if far. Maintains comfortable distance.. The second setting specifies the behavior when there is no enemy: default - Stand still. PETMOVE - The monster follows the player until it is called off and will try to attack whatever the player is attacking. CIRCLE1 - The monster will move in a circle until it is attacked, or until it finds an enemy. This is good for non-aggressive monsters and NPC. ...
ABOUT MONSTER Monster was founded over 30 years ago by Head Monster Noel Lee, who was recently honored with the prestigious Plus X Award®: Lifetime Achievement Award, as a company dedicated to creating products that enhance the sound quality of music. The company engineered the sound of the acclaimed Beats by Dr. Dre® headphones, and has become the worlds leading manufacturer of high-performance, sonically superior headphones, all of which feature the companys Pure Monster Sound™. Monster is also the worlds leading manufacturer of advanced connectivity solutions for high-performance home entertainment, audio, home cinema, computer and gaming as well as a leading innovator in the field of mobile accessories and professional audio. The company also provides high-performance AC power line conditioning and protection products for audio/video systems, as well as energy-saving power products. Monster continues to lead in innovation with over 300 U.S. and international patents and dozens ...
Fetus in fetu (FIF) is an extremely rare condition (1/500,000 live births) in which a fetiform structure is incorporated into the body of its twin. FIF can be a diagnostic dilemma due to its similarity to a teratoma, but identification of FIF is impo
Shelley described Frankensteins monster as an 8-foot-tall (2.4 m), hideously ugly creation, with translucent yellowish skin pulled so taut over the body that it "barely disguised the workings of the arteries and muscles underneath"; watery, glowing eyes, flowing black hair, black lips, and prominent white teeth. The monster attempts to integrate himself into human society, but is shunned by all who see him. This compels him to seek revenge against his creator. A picture of the creature appeared in the 1831 edition. Early stage portrayals dressed him in a toga, shaded, along with the monsters skin, a pale blue. Throughout the 19th century, the monsters image remained variable according to the artist.. The best-known image of Frankensteins monster in popular culture derives from Boris Karloffs portrayal in the 1931 movie Frankenstein, in which he wore makeup applied, and according to a format designed by, Jack P. Pierce and possibly suggested by director James Whale. Universal Studios, which ...
Monster of Montauk The "Montauk Monster" washed up onshore of a New York beach in Montauk, Long Island. Several onlookers took pictures of it, sending it via e-mail on Wednesday.. According to Newsday, Alanna Navitski, an employee for Los Angeles Evolutionary Media Group, was behind the media frenzy. Navitski sent the picture of the "monster" to Anna Holmes, the managing editor at Jezebel, who then sent it to Gawker.. Gawker published the photo with the headline "Dead Monster Washes Ashore in Montauk".. Many believe that it is a sea turtle without a shell or the remnants of a government animal-testing facility nearby. However, no scientific specialist has yet to identify what animal or creature this "Montauk Monster" truly is. And, the fact that the picture itself is real, and not one more falsification, should be still proven. In the age of digital photography and slick graphic artists, it is so easy to make us believe in something that is not exactly a reality.. Additional ...
Off Mystery Cove, Monster Rallys new album. Out on 11/11/16, available as a limited edition 12″ here.. When the beach party film revival arrives, Ted Feighan (aka Monster Rally) will be the Ennio Morricone of its resurgence. Mystery Cove, the forthcoming Monster Rally album, is a soundtrack to an imaginary movie both fit for the vaults of TMC and primed for a grindhouse exploitation flick screening. Mystery Cove contains a narrative arc of young lovers on an island getaway. As the grooves spin, Monster Rally reveals a cabalistic presence in the jungle that leads them on an adventure of surf competitions ("The Big Surf"), voodoo terror ("Tourismo"), and plenty of slushy cocktails ("After Hours"). The occult meets the salt-rimmed rum mix on Mystery Cove.. Since his Coral LP, Monster Rally has been an analog to the exotica forefathers. His reinvention of cocktail music via luau-loops and tchotchke breaks evokes a mondo vision of the subgenre. With Mystery Cove, the quiet village is not what it ...
Even Nicoles ornaments have been taken over by monsters. "You see…monsters have a fondness for shiny and colorful objects so it makes sense that my monsters have begun to claim Christmas ornaments as their own," she explains.. Visit her blog for ramblings on life with monsters and her Flickr site for more pix. Have a humorous weekend and make peace with your monsters.. ...
About Costume Shop Monster Child Costume [Animals and Insects] - Run and hide!Your little monster will be hideous and produce fear by its terrifying appearance in the Monster Child Costume. This freak of nature disguise includes a button down monster onesie jumpsuit with an attached monster head hood and tail. Available in Child Sizes: 2T-6. Includes: Jumpsuit. Product Page
Is there a part of you that somewhere, deep inside, believe that youre actually a…MONSTER? And how much energy have you been spending hiding that from the world? Here is the question: What if you ARE a monster - a monster of magic? What if that "monster"" you are so afraid of being and exposing, is the most beautiful, gentle, kind, caring, potent invitation to a greater possibility that this world has ever seen? Most of us judge and hide the thing that is so beautiful about us, the thing that would change this world for the greater, because its totally inconceivable to this reality. Where could you be, if you gave up hiding? What could be unleashed if the secrets no longer had to be protected? Who would come out if you tore down the wall you put up to protect the world from you? What if all that energy youre spending hiding your monster is what is actually required to create the world youve always hoped for could come into existence? Youre invited to become the walking, talking, soaring ...
MONSTER MONSTER DEL 2, KARATEMUMIEN i Tidningsarkivet. Ett digitalt arkiv för svenska tidningar och tidskrifter. Här finns bland annat omslag och innehållstexter för MONSTER MONSTER DEL 2, KARATEMUMIEN.
You dont have to visit a laboratory to become a monster with our Monster Stitch Knee-High Socks! Monster Knee-High Socks are green with black monster stitches details.
Monster Beverages first-quarter results made last quarters poor performance look like a one-time aberration. Adjusted net sales jumped almost 16% to $680.2 million, doubling the pace of last quarters growth and easily topping the 12% growth rate that most investors were hoping to see. Adjusted net income performed even better, jumping by almost half to $166.1 million. That produced adjusted earnings of $0.80 per share, compared to the $0.74 per share consensus forecast among investors.. Looking more closely at Monsters figures, some of the same trends weve seen in past quarters continued. Currency-related issues once again hit Monsters results, but to a lesser extent than weve seen in recent reports. The company said that net sales took a $12.3 million hit, or less than two percentage points, because of the strong dollar. Overall, net sales to customers outside the U.S. rose at a much faster pace than domestic sales, jumping 32% and making up more than a fifth of Monsters total ...
Five people may have died in the past three years after drinking Monster Energy, according to reports released by the FDA. The reports do not prove a link between Monster Energy and the deaths or health problems. The mother of a 14-year-old Maryland girl who died from a heart arrhythmia after drinking Monster Energy on two consecutive days sued the company. A spokeswoman for Monster Beverage said last week that its products were safe and not the cause of the girls death.
Monster Jam - Orlando 2008 - Grave Digger Freestyle Monster Jam is the worlds largest and most famous monster truck tour featuring the biggest names in mons...
The Movie Monster Game is an arcade game by Epyx from 1986. The player can haunt a town of his choice with a movie monster and fulfill a previously chosen mission there, e.g. destroy a sight, rescue your abducted young or simply destroy everything. Police, tanks, jets and other opponents give him a hard time. Tear down houses with your mere fists! Swallow tanks in one piece! Give Big Ben one on its bells or bend the Eiffel Tower: dreams as old as manhood itself. Already in 1983 did Epyx attend to this basic need of human existence and produced a game with the promising title "Crush, Crumble & Chomp", which was about destroying as much as possible as a movie monster. In 1986 the game -at that time written in Basic - was found to be not en vogue enough any more and decided to release an improved version: The Movie Monster Game. They even invested in a licence to be allowed to use the name of the Japanese national hero Godzilla. The game starts with the options screen presenting itself as the outer ...
Well, like I said, the mini "movies" are just plain shi-tty. They look like somebody got 20 homies together and thought up little scenes to shoot, like some fools rollin by dumpin on a funeral. I think they were completely wortheless. But the parts with monster were pretty tight. I had seen him interviewed a few times on TV mostly when he was locked up and on the black power prison shi-. But this was him just being a banger. Hes rolling in the car with a camera man and sees some fool walking lookin like a banger with cornrows. Monsters like "watch this" and has them stop and he hops out. He hits the fool up and dude tells him his name is Kaos and acts like hes all hard for a second. Monsters like "Monsta Kody, eight tray gangsta" and this fool damn near wets his self and starts back trackin like nah, well, kaos is just sort of what i call myself, and uh I dont really bang or get down like that. Monster starts just clownin his ass. Then he just sits around smokin weed talkin bout shootin ...
Foetus-in-foetu is a rare malformation in which a monozygotic diamniotic parasitic twin is incorporated into the body of its fellow twin and grows inside it. Less than 100 cases have been reported in literature. One day old newborn male was admitted with antenatal diagnosis of abdominal mass. It was cystic/solid in nature with pressure effects on left ureter and urinary bladder, most likely to be a germ cell tumour. Birth history was uneventful. Exploratory laparotomy was performed and the mass was excised. Physical examination confirmed the diagnosis of foetus-in-foetu. Although it is a rare condition, imaging may play an important role in the correct prospective diagnosis of foetus-in-foetu. Surgical excision is the recommended treatment.
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The Thread Monster (Seamus fraydicus) is generally found nesting in untreated seams. Infestation begins during the washing process, when the agitation of water begins to loosen the cut fibers of the fabric. Thread Monster larva need heat to fully mature, and usually require several trips through the dryer before reaching adult size. However, as they grow they extend their territory and seek loose threads elsewhere on the seam they inhabit. The resulting nest can become sizable. The fibers become firmly matted together, often causing the seam to buckle and bind. The normal solution to infestation is to rip out these fibrous nests when they become large enough to cause problems, resulting in damage to the seam allowances of the garment. In extreme cases, a nest in a prime location (the bottom of an armscye, for example) will gather threads from several adjoining seams, and removal may damage the garment itself. Thread Monsters inside of lined garments have a particularly protected home, and are ...
iClone 5s new Avatar Toolkit: Monster Workshop has arrived on the main Content Store. Includes a bunch of Spore-like creature components, to swop and mix at the whim of your inner Mad Scientist, to build a unique monster for animation. Puppeteering of your Monster Workshop creatures requires the iClone Avatar Toolkit plugin, a plugin that…
Kinetics: TOY MACHINE x Kinetics MONSTER 6Panel Cap (2 colors) (toy machine kinetics Monster 6-Panel Cap) - Purchase now to accumulate reedemable points! | Rakuten Global Market
My co-collaborators on this project and I have often discussed doing a monster card set of some kind over the past several years ( of our association working on a certain notorious non-sports card franchise) and we finally took the plunge- having no idea really what to expect . Ive always maintained monsters are beloved and monster cards most of all , but we hadnt thought to incorporate pin-up art into the equation. Thus CREEPING FLESH was born ( or raised ...
Monster Multi with Free Monster Pump NOS information including description from Cytosport, supplement facts, and suggested use. Order online for quick delivery at the best prices.
For Monster Hunter 3 Ultimate on the 3DS, a GameFAQs message board topic titled What monster you fear the most in MH series? - Page 4.
Monster Island is one part sandbox setting and one part monster manual for Runequest 6. The book consists of a lengthy introduction to Monster Island proper, including a map. The print version has a full color pull-out version, and a separate Companion download for $4.99 includes this map with some collected charts and tables; presumably this keeps the price down on the main PDF. For those concerned about price, the black and white maps in the main book are perfectly serviceable. I havent picked up the Companion yet, but will let you know if its worth it when I do (come on rpgnow sales, dont fail me now ...
Videoklip, překlad a text písně Problem (The Monster Remix) ft. will.i.am od Becky G. Im a monster, Im a m-monster Im a monster, Im a m-monster..
An essay by Tyler Naffin:. For as long as I have known the meaning of the term, I have considered myself an atheist. Recently however, I have begun to reconsider my atheism. The cause of this reconsideration is Pastafarianism. Pastafarianism is a religion that was brought to my attention when I read an article in the November 2006 issue of Wired magazine called The New Atheism. In an interview with renowned atheist and evolutionary biologist Richard Dawkins, he mentioned the deity of Pastafarianism, the Flying Spaghetti Monster. At first I thought nothing of it, but a few weeks later I noticed a YouTube clip that had a Flying Spaghetti Monster sighting in Germany. As soon as I discovered that His Noodiliness was not a figment of Dawkins imagination, I began to research the Flying Spaghetti Monster. I discovered that it was part of the Pastafarian religion, and upon learning of some of its tenets, I was instantly converted. But this would seem to be at odds with my atheism, to believe in a god. ...
An infant falls mysteriously ill. A biology professor becomes an unexpected host. A family man is brought to the brink, all in this episode of Monsters Inside Me.
An infant falls mysteriously ill. A biology professor becomes an unexpected host. A family man is brought to the brink, all in this episode of Monsters Inside Me.
In this tall tale, the Kid encounters a huge saurian creature, seemingly out of time. Disappointingly, the beast turns out to be a costumed bison, but the final panel of this page displays a wonderful angle of the faux-reptile. Ably inked by Dick Ayers, Kirby sets up the tableau masterfully, as he shows us the Kid in the preceding panel emerging from a rent in the wood, his body positioned just over the tail of the creature below. The gunfighters gesture and pose powerfully accentuate the torque of the monster in the lower panel as it faces the Kid with gaping jaws.. In Rawhide Kid#22, cover dated June 1961, we finally get the real deal, an actual monster in a western setting. While as usual on the run from the law, the Kid takes a dangerous job in Silver mine and is menaced by an underground creature, the Living Totem.. ...
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Who has never wanted to be a monster for a day? We know we have, which is only part of the reason we love this insane knitted monster masks from Brutal Knitting, which we spotted over at Nerdcore. Brutal Knitting, also known as Tracy Widdess, does…
Make handing out candy to trick-or-treaters more fun this Halloween with these Skeleton & Monster Fingers! Wear all monster fingers or all skeleton fingers or ...
Walkthrough - Armor Skill FAQ Walkthrough for Monster Hunter Freedom 2 PSP: Page 1 ~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~ \ MONSTER HUNTER FREEDOM 2 / / ARMOR SKILL FAQ \ ~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~+~ Author : Brian Wang KingofMH (GameFAQ) E-mail : [email protected] MSN: : [email protected] Version : 3.4 ...
... - THE GALLERY IS HEREQuick! Let s make this cute monster plush! Go to http://www.dailyplush.com/tutorials/how-to-sew-a-plush-monster t
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A fun way to review alleles, Punnett squares, phenotypes and genotypes. The students determine the allele combinations(basic), pheno- and geno- types of a Male and Female monster. Then, they flip the coin to determine the genes of the baby monster.
Revision History) GAMES: SMRPG. TYPE: Mechanical, Monster. TURF: Castles. AFFILIATIONS: None. CLOSE RELATIVES: Orb User. SKILLS AND ATTACKS: Recover, Mega Recover.. STRENGTHS: Fire, Thunder and Ice attacks.. WEAKNESSES: Jump attacks, Genos Attacks, Crusher, Poison.. BACKGROUND: These living magical staffs are modified Orb Users. Valentina acquired several Orb Users from Booster and had one of her Shamans use their magical powers to enhance them. They can now user powerful healing spells ...
This is the granny monster of Sucrettes blog. Ive enjoyed so much making it that Ive decided to make a blanket of grannies. What I havent decided yet is whether the grannies will be the same of the granny monster or theyll be different. Thanks, Sucrette!! ...
Battle not with monsters, lest ye become a monster, and if you gaze into the abyss, the abyss gazes also into you. Friedrich Nietzsche What does this mean to you? Terry Elkins (whyguy)
You, I or someone who matters, could easily spend oodles of time, examining what Cookie Monster is saying in the below picture but lets not. Lets hack straight to the chase: Cookie Monster doesnt have…. Read more » ...
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Welcome to the monster high fanclub! Info: here is were we can make Ocs (Original characters), talk about the monster high rumors, maybe do Pm Rping...
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Thinking about it, I should have saved the title for when I talked about Outsiders (i.e. alien beings and elementals) and Constructs (i.e. robots). Oh well, wasted play on words. But, I really enjoyed jabbering about D&D Monsters this week. Also, I havent gotten my copy of the Monster Manual in the mail (as…
Monsters lyrics - Keep goin getting higher New worlds waiting in the sky Escape the feasting and the hunger Not the monsters in our minds Got our hands on a ship And...
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Hey divas, you all know how much I love my puppy, the insatiable, incorrigible Adorable Snow Monster. He happens to be one of the worlds most spoiled dogs based on the treasure trove of toys Kuzak and I have thrust upon him - a giant mound in our living room that once prompted the UPS man to ask if we have multiple children. "No, kids in this house," I replied, "unless you count my boyfriend." The fact that our weekly puppy class takes place inside a Petco does not help this fact. Yesterday, after our class in which the Monster was so distracted by the traffic that he wouldnt even sit for me, I rewarded him with a new toy frisbee. For months, Kuzak and I have been fantasizing about training him to be one of those graceful, acrobatic pups we see at the dog park that leap into the air, fluidly snatch a frisbee out of midair and then blithely trot back to their owners, dropping their prize generously at their feet ...
Kingdom Death is raising funds for Kingdom Death: Monster 1.5 on Kickstarter! A cooperative nightmare horror game experience. Hunt intelligent monsters and develop your settlement through a self-running campaign.
Unexpected, unscripted and unforgettable, Monster Jam takes center stage in the world’s iconic venues like Mohegan Sun Arena in Wilkes-Barre sporting meticulously manicured dirt tracks created with the sole purpose of pushing these perfectly engineered, larger-than-life trucks to the limit.  Driver of the Megalodon Monster Truck Justin Sipes joins us with more.
Number Appearing: Monsters may be encountered alone or in groups and abroad or in their lair. Occasionally, a monsters lair may be discovered unguarded. To determine the exact conditions, an eight-sided die is rolled and the result looked up under encounters for the monster in question. For example, a monsters description may state: "Number Appearing: 1-3: abroad (2d4), 4-7: lair (2d10), 8: lair (empty)". Thus, a d8 roll resulting in a 1 to 3 means that 2d4 individuals are encountered abroad, a roll resulting in 4 to 7 means that the PCs have stumbled upon 2d10 monsters in their lair, and a roll of 8 means that the empty lair has been discovered ...
because I couldnt handle it.. By the time I hit Theta the monster encounters were annoying me because they interrupted my exploration of the level and causing me to miss elements of the environmental storytelling. The problem is oddly the opposite of one of Amnesias biggest problem. While Amnesia relied heavily on scripting monster encounters, meaning most of the time monsters disappear after patrolling a set route for a minute or so, SOMA went to the other extreme and made monsters patrol a route or area indefinitely. While this greatly increased the tension for me at first, it got old after a while because of the problem I mentioned above.. I feel SOMA would be improved if there was an element of randomness involved in most of the monster encounters - they appear after a random amount of time, patrol for a random amount of time, and then disappear again to leave you free to explore the area. It would make the game much more unpredictable while also allowing the player to fully explore most ...
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Posted on 05/10/2011 4:29:31 PM PDT by driftdiver. Rosie O Donnell is making some waves suggesting America may have become the type of monsters we loathe with our targeted killing of Osama bin Laden. Uncomfortable with the wild celebrations last week of drunken fraternity boys celebrating Bin Laden s death in New York and Washington, Rosie also reveals that she expects America to be an example for how we want other countries to act and was disappointed we were not the leader of morality and fairness here. Rosie explains: You can also be upset about the fact that he didn t have due process, that he didn t get tried, that he wasn t you know brought to The Hague for war-crime tribunal. . . . Many, many people, including now on the Twitter feed say, Well, Rosie, it was illegal for them to fly planes into the Twin Towers. I m fully aware of that. Because other people are capable of criminal acts on our soil doesn t equate to therefore, we are allowed to do criminal acts on their soil ...
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Buy Monster University My Scare Pal Mike from our Soft Toys range at Tesco direct. We stock a great range of products at everyday prices. Clubcard points on every order.
Home Depot has the Monster Moto 1000-Watt Electric Mini Bike for a low $299.00. Shipping starts at $79, or you can buy online and pick up in-store...
But you may retort that there is more than one Loch Ness Monster and they must die on a regular basis, thus making them more amenable to a search. I would agree with you on that matter. Nobody knows when this creature entered the loch, but in the estimated 20 metres or more of deposits laid on the loch floor since the last Ice Age, there must be a good number of bones in varying stages of decomposition. Indeed, it is hoped that if the bones are encased in the clay quick enough before the slightly acidic waters totally breaks them down, there is a good chance of many examinable bones being found. I say that with a degree of optimism since I am not even sure if bones of known animals have been found in the various core samples collected over the last 20 years ...
The YouTube channel KittiesMama provides video tutorials for recreating the makeup looks of various Monster High dolls. Each video runs between five to seven minutes in...
Watch Digimon: Digital Monsters - Season 5, Episode 13 - The Rise of RizeGreymon: Merukimon has defeated GeoGreymon, Gaogamon, Sunflowmon, and Biyomon. Biyomons Digi-Egg is then taken back to the Digit...
Ragnar Þórhallsson and Nanna Bryndís Hilmarsdóttir of the band Of Monsters And Men perform on stage during the London Launch of Logitech UE at Village Underground on September 25, 2012 in London, United Kingdom.
A reading worksheet for assigning Whoever Fights Monsters projects & homework assignments. Part of a comprehensive Lesson Plan from BookRags.com.
So its 3 AM here, Im in the middle of doing a huge paper, and I got so frustrated with this picture (that I was irresponsibly painting at the same time!) that I figured that maybe if I came here perhaps one of you many talented artists could help me! Picture in question: http://img217.imageshack.us/img217/6392/buildingjungle.png I realize that they do not look very...connected/flowing/etc together. This is because the monster was a more recent, experimental addition (before that I
Play as your favorite freaky-fab ghoul while jumping, climbing and swinging through multiple mystical levels to save Monster High and their ghoulfriends
Lyrics to Meet The Monster by Five Finger Death Punch: [V1:] / Its not that complicated and you aint gotta believe / Theyll put me down
How does Monster Hunter 3G look to someone new the the franchise? Pretty darn good, apparently. A look at Capcoms huge franchise from TGS 2011.
It rose up out of the sea, a fearsome, roaring monster unlike anything humans had ever seen: horrible, primeval, unstoppable, towering, breathing radio ...
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Read The prologue and the first two chapters of Eliza And Her Monsters by Francesca Zappia! Plus get a sneak peek into the pages and illustrations!
Fukuda approached this as pure escapism, with a fast-paced story that also weaves in Youth Movie elements with James Bondian histrionics - Takaradas hot-headed safecracker, a sinister organization bent on world domination through nuclear proliferation, and a band of teenagers swept up into the action, with whom the target audience could indentify. It is quite apparent that little was revised in the changing of the central monster from Kong to Godzilla, because of the odd Kong-like ticks adopted by Godzilla - his attention directed at a beautiful woman, his battles with a Giant Condor and a Jet Squadron, his boulder-throwing antics, and the rubbing of his nose (ala Kayamas character in the aforementioned YOUNG GUY series). The colorful film is an unusual, but highly enjoyable, adventure - despite its relatively lower budget - and is one of the most underrated of the 1960s entries ...
From: Mashable: Watercooler-- Kathy Bates is very tired, what dont you monsters understand about that? The American Horror Sto..
Lady Gaga may have canceled her tour, but she wasnt going to let one terminally ill little monster miss her chance at meeting her idol.
Hey everyone, Sorry, lost initial post so this will be a bit quicker and to the point. I see a lot of threads about difficulty of leveling in WoW and the ease of it. I also see complaints about the world not being threatening enough anymore. I think we should implement Diablo 3s Monster Power system to help this problem for those who want to fix it. The beauty of the MP system is that it can create a more dangerous works but is entirely optional. I think the MP system in WoW should take
Evan visits an old toy store and buys a dusty can of Monster Blood. But then he notices something weird about the slimy green ooze. It keeps growing. And growin
It has taken the better half of a year for it to happen, but finally fans of BOOM! Studios DRACULA: IN THE COMPANY OF MONSTERS will get the showdown tha
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Sidebrow | Roxanne Carter | Beyond This Point Are Monsters | a few drops of sweat attend her body - anemones, bracketed by nylon and lace. she throws open the width, observes an opposing movement: the house withdrawing into itself, anger spiked by embroidery floss, spun sugar. ...
Pre-made tests on The Gospel of the Flying Spaghetti Monster Final Test - Easy, including multiple choice, short answer, short essay, and in-depth essay questions.
Racing game with monster trucks. Win races across the world in metropoles. You need to get to the top ranking of riders. Overtake all rivals and recharge your turbo boost by jumps over wrecks on the track. A funny car game 3D! Controls: arrows, X
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This time last year I was fighting a difficult battle with the depression monster. Having received a power up over Christmas from actually seeing friends for th...
Directed by Rob Letterman, Conrad Vernon. With Reese Witherspoon, Rainn Wilson, Stephen Colbert, Seth Rogen. A woman transformed into a giant after she is struck by a meteorite on her wedding day becomes part of a team of monsters sent in by the U.S. government to defeat an alien mastermind trying to take over Earth.
And now we come to it. My first whale. I suppose, for good or ill, I have never outgrown some of my childhood. Even now, at the decrepit age of 41 (!) I am still fascinated by monsters. More specifically, drawings of monsters. Monster art. Anything visual thats monster related. As Ive grown older, my…
And now we come to it. My first whale. I suppose, for good or ill, I have never outgrown some of my childhood. Even now, at the decrepit age of 41 (!) I am still fascinated by monsters. More specifically, drawings of monsters. Monster art. Anything visual thats monster related. As Ive grown older, my…
.flickr-photo { border: solid 2px #000000; }.flickr-yourcomment { }.flickr-frame { text-align: left; padding: 3px; }.flickr-caption { font-size: 0.8em; margin-top: 0px; } zz ingrid pitt the house that dripped blood, originally uploaded by Boju. Everyone knows Freddy and Jason, Frank and Drac, but ask anyone who the greatest female monsters are, and theyll likely draw a…
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Hot Wheels Monster Jam: Max-D Wolverine Die Cast Truck Diecast body. Large 1/24 scale 1:24 Scale - Diecast Metal read more... ...
Lunalight Blue Cat has two effects. The first can only be used once per turn and cannot target Lunalight Blue Cat. It gives a different Lunalight monster 1000 Atk until the end of the turn when she is Special Summoned. This would help powerful fields become more powerful for a turn, but its not permanent, so take it with a grain of salt. The main effect is the second one because it can Special Summon any Lunalight monster from the deck including herself multiple times per turn. Blue Cat simply needs to be destroyed from the field to activate that effect. The from the field part hurts this usefulness a bit, but it is still the necessary effect to get Lunalights to the grave for future Fusion plays, or to get another Blue Cat to pump the attack of one of your other monsters. With more Lunalight monsters to come this effect will become more useful, and the card as a whole is absolutely necessary because of that effect. However, Lunalights as a deck now are just fun and not really competitive ...
Friend and toymaker Jon Malmstedt (Rampage Toys) sends us this REALLY exciting work-in-progress image of a new sofubi he will be helping produce locally in Tokyo: The Manotaur. Designed and sculpted by Justin Hillgrove (Imps and Monsters), this awesome 8-inch Japanese soft vinyl toy will be made in limited colorway runs. The aim is to debut the toy at Justins booth at the Emerald City ComicCon in Seattle in the spring ...
A new trailer could maybe get some attention by being shared around the Internet. Im not talking about using it to replace the current pitch or trailer. It would be an alternate trailer much like how movies will have multiple versions of a trailer over time. It maybe doesnt even have to be a trailer. If the objective is to show off cool Filipino monsters and create a creepy atmosphere then it could almost like a developer diary talking about the monsters while sitting in a dark room or forest. Concept art for the monsters could be faded in the corners of the screen when a monster is talked about ...
You can also use the Absorb command on enemies. This drains their Wickedness gauge, raising the chance they will join you when defeated. Although a wicked monster would rather die than join you, monsters without high Wickedness factor will surrender to you instead. More powerful monsters have more Wickedness and require more Absorbing. The chance of a monster joining you is inversely proportional to the percentage of energy remaining in their Wickedness gauge. Beware that some enemies have Infinite Wickedness, making it impossible to cause them to join you ...
Is your dog an out of control monster? Do you wish you could tame the savage beast to have a calm dog that has self-control? Read this for help!
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... an indication of abnormality of a cell (which may be indicative for malignancy). Significance of the abnormality is highly ... Less commonly, and seen usually in infants, are teratomas and atypical teratoid rhabdoid tumors. Germ cell tumors, including ... or more severe symptoms such as tremors, paralysis on one side of the body hemiplegia, or (epileptic) seizures in a patient ...
... malignant M9502/0 Teratoid medulloepithelioma, benign M9502/3 Teratoid medulloepithelioma M9503/3 Neuroepithelioma, NOS M9504/3 ... CIN III with severe dysplasia (C53._) Vaginal intraepithelial neoplasia, grade III (C52._) VAIN III (C52._) Vulvar ... abnormalities AML, MLL M9910/3 Acute megakaryoblastic leukemia, NOS Megakaryocytic leukemia (FAB-M7) M9920/3 Acute myeloid ... chromosome abnormality M9989/3 Myelodysplastic syndrome, NOS Medical classification International Classification of Diseases ...
progressive dementia or stupor in patients with a nonfocal neurologic exam and minimal abnormalities on MRI (more common in ... is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS). ...
Atypia: an indication of abnormality of a cell (which may be indicative for malignancy). Significance of the abnormality is ... Less commonly, and seen usually in infants, are teratomas and atypical teratoid rhabdoid tumors.[66] Germ cell tumors, ... Grade I tumors are the least severe and commonly associated with long term survival, with severity and prognosis worsening as ... or more severe symptoms such as tremors, paralysis on one side of the body hemiplegia, or (epileptic) seizures in a patient ...
Atypia: an indication of abnormality of a cell (which may be indicative for malignancy). Significance of the abnormality is ... Less commonly, and seen usually in infants, are teratomas and atypical teratoid rhabdoid tumors.[65] Germ cell tumors, ... or more severe symptoms such as tremors, paralysis on one side of the body hemiplegia, or (epileptic) seizures in a patient ...
Abnormalities, Drug-Induced. *Abnormalities, Multiple. *Abnormalities, Radiation-Induced. *Abnormalities, Severe Teratoid. * ... "Musculoskeletal Abnormalities" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... IHH Gene Mutations Causing Short Stature With Nonspecific Skeletal Abnormalities and Response to Growth Hormone Therapy. J Clin ... This graph shows the total number of publications written about "Musculoskeletal Abnormalities" by people in Harvard Catalyst ...
Abnormalities, Drug-Induced. *Abnormalities, Multiple. *Abnormalities, Radiation-Induced. *Abnormalities, Severe Teratoid. * ... "Musculoskeletal Abnormalities" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Musculoskeletal Abnormalities" by people in this website by ... Below are the most recent publications written about "Musculoskeletal Abnormalities" by people in Profiles. ...
Congenital Abnormalities. Abnormalities, Severe Teratoid. Folic Acid. Vitamin B Complex. Hematinics. Vitamins. Micronutrients. ...
Abnormalities, Severe Teratoid. Congenital Abnormalities. To Top. *For Patients and Families. *For Researchers ...
Subjects: Abnormalities Abnormalities, Human Abnormalities, Severe Teratoid Animals Dwarfs Electronic books Giants Monsters ... Subjects: Abnormalities Abnormalities, Human Abnormalities, Severe Teratoid Animals Anthropology Electronic books Occultism ... Subjects: Abnormalities Abnormalities, Human Animals Causes and theories of causation Congenital Abnormalities Disease Diseases ... Subjects: Abnormalities Abnormalities, Human Animals Conjoined twins Early works Early works to 1800 Fetal presentation Human ...
Abnormalities, Severe Teratoid. Twins, Conjoined. 16. [Illuminated letter U] Publication:. Bethesda, MD : U.S. National Library ... Abnormalities, Severe Teratoid. 6. Polomie Publication:. Bethesda, MD : U.S. National Library of Medicine, National Institutes ...
Abnormalities, Severe Teratoid. 6. Polomie Publication:. Bethesda, MD : U.S. National Library of Medicine, National Institutes ...
Abnormalities, Severe Teratoid. Anatomy. Artificial Limbs. Distillation. Fractures, Bone. Legendary Creatures. Nervous System. ...
C16 - Congenital, Hereditary, and Neonatal Diseases and Abnormalities. Monsters. Abnormalities, Severe Teratoid. ...
Teratoid (severe)O. Teratoid (moderate)P. Normal spermatozoa. Male factor infertility may result from low sperm count or low ... The treatment is completely free of any side effects.Medicine is effective in 95% in sperm abnormalities i.e. Low Sperm count, ... Cells exposed to significant levels of radiation may take up to two years to resume normal sperm production, and, in severe ... A.Normal Sperm B. Knobbed acrosome (beaded form)C. Pyriform head (severe)D. Pyriform head (moderate)E. Pyriform head (slight)F ...
Abnormalities, Radiation-Induced (0) * Abnormalities, Severe Teratoid (0) * Aicardi Syndrome (0) * Cardiovascular Abnormalities ... Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) * Congenital Abnormalities (3) * Abnormalities, Drug- ... in Abnormalities, Multiple by mythara My 4yr old daughter was diagnoised w/ Partial Facial Paralysis and now has been found to ...
Severe Teratoid., Sexually Transmitted Diseases., Exhibits as Topic., Museums., Anatomy.) ... Liverpool Museum of Anatomy (Sexually transmitted diseases., Monsters., Masturbation., Anatomical museums., Abnormalities, ... Abnormalities, Severe Teratoid. *Sexually Transmitted Diseases. *Exhibits as Topic. *Museums. *Anatomy. Genre. *Electronic ...
ATYPICAL TERATOID/RHABDOID TUMOR OF THE CENTRAL NERVOUS SYSTEM : The patient is a four year old Caucasian girl with a ... MYOPATHY WITH CYTOPLASMIC BODIES AND MULTI-CORES. A 32-year-old woman with anorexia nervosa and depression developed severe ... constitutional ring chromosome 22 abnormality.. * PILOCYTIC ASTROCYTOMA: This 22 month old white female presented with an 8 ... week prior presented with mental status changes and a severe occipital headache of two days duration. ...
... an abnormality in the production of beta chains which causes the red cells to more easily breakdown resulting in mild to severe ... Atypical Teratoid Rhabdoid Tumor. An atypical teratoid rhabdoid tumor, is a fairly rare aggressive tumor usually diagnosed in ... Severe Combined Immune Deficiency. Severe combined immune deficiency is a rare genetic birth defect that doesnt allow the body ... Alpha thalassemia is an abnormality in the production of alpha chains which causes the red cells to more easily breakdown. ...
Severe combined immunodeficiency. 1 , 51 Severe congenital neutropenia. 1 , 12 THYMUS ABNORMALITY. 1 , 3 ... atypical teratoid / rhabdoid tumor. 1 , 5,112 ear infection chronic. 1 , 52 ependymoma. 1 , 4,679 ...
A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination MAMMALIAN GENOME Noveroske, J. K., Hardy, R., Dapper ... Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to ... and atypical teratoid rhabdoid tumor (ATRT). Seventeen patients received LC (2 mg/kg up to 50 mg, every 2 weeks to monthly) at ... Here we report on a patient who presented at 7 years of age with loss of consciousness and severe metabolic acidosis following ...
A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination MAMMALIAN GENOME Noveroske, J. K., Hardy, R., Dapper ... Biochemical abnormalities seen in some MMA patients, such as lactic acidemia and increased tricarboxylic acid cycle ... and atypical teratoid rhabdoid tumor (ATRT). Seventeen patients received LC (2 mg/kg up to 50 mg, every 2 weeks to monthly) at ... Here we report on a patient who presented at 7 years of age with loss of consciousness and severe metabolic acidosis following ...
Abnormalities, Drug-Induced. Abnormalities, Multiple. Abnormalities, Radiation-Induced. Abnormalities, Severe Teratoid. ... Eye Abnormalities. Eye Diseases, Hereditary. F. Fabry Disease. Factor V Deficiency. Factor VII Deficiency. Factor X Deficiency ... Stomatognathic System Abnormalities. Sulfatidosis. Syndactyly. Synostosis. Syphilis, Congenital. T. Tangier Disease. Tay-Sachs ... Skin Abnormalities. Skin Diseases, Genetic. Smith-Lemli-Opitz Syndrome. Smith-Magenis Syndrome. Sotos Syndrome. Spastic ...
Abnormality, Respiratory System use Respiratory System Abnormalities Abnormality, Severe Teratoid use Abnormalities, Severe ... Abnormalities, Nervous System use Nervous System Malformations Abnormalities, Radiation Induced use Abnormalities, Radiation- ... Abnormality, Nervous System use Nervous System Malformations Abnormality, Radiation-Induced use Abnormalities, Radiation- ... Abnormalities, Congenital use Congenital Abnormalities Abnormalities, Congenital, Nervous System use Nervous System ...
Abnormality, Respiratory System use Respiratory System Abnormalities Abnormality, Severe Teratoid use Abnormalities, Severe ... Abnormalities, Nervous System use Nervous System Malformations Abnormalities, Radiation Induced use Abnormalities, Radiation- ... Abnormality, Nervous System use Nervous System Malformations Abnormality, Radiation-Induced use Abnormalities, Radiation- ... Abnormalities, Congenital use Congenital Abnormalities Abnormalities, Congenital, Nervous System use Nervous System ...
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... for the first time the use of flexion-extension MRI to clear neonates with severe congenital cervical spine abnormalities for ... atypical teratoid rhabdoid tumor, primitive neuroectodermal tumor, pediatric glioblastoma, and diffuse intrinsic pontine glioma ... Rapid-sequence brain magnetic resonance imaging for Chiari I abnormality JOURNAL OF NEUROSURGERY-PEDIATRICS Pan, J., Quon, J. L ... Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial CRITICAL CARE MEDICINE Okonkwo ...
teratoid tumor teratoma.. testicular tumor a general term for any tumor of the testes; in adults these are almost always ... It may be accompanied by congenital defects such as urinary tract abnormalities, absent iris of the eye, and asymmetry of parts ... tumor lysis syndrome severe hyperphosphatemia, hyperkalemia, hyperuricemia, and hypocalcemia occurring after effective ... teratoid tumor. A tumor of embryonic remains from all germinal layers. See: teratoma ...
Abnormalities, Drug-Induced. *Abnormalities, Multiple. *Abnormalities, Radiation-Induced. *Abnormalities, Severe Teratoid. * ... A 3.1-Mb microdeletion of 3p21.31 associated with cortical blindness, cleft lip, CNS abnormalities, and developmental delay. ... Karyotype versus microarray testing for genetic abnormalities after stillbirth. N Engl J Med. 2012 Dec 06; 367(23):2185-93. ... Telomerase mutations in smokers with severe emphysema. J Clin Invest. 2015 Feb; 125(2):563-70. ...
  • it is characterized by blood vessel abnormalities, particularly abnormal twists and turns (tortuosity) of the blood vessels that carry blood from the heart to the rest of the body (the arteries). (malacards.org)
  • other blood vessel abnormalities that may occur in this disorder include constriction (stenosis) and abnormal bulging (aneurysm) of vessels, as well as small clusters of enlarged blood vessels just under the skin (telangiectasia). (malacards.org)
  • There are a large number of inherited genetic (passed from parent/s to child) disorders of platelet function, which may be divided into 5 groups depending on the type of abnormality (i.e. (nicklauschildrens.org)
  • Disorders of platelet adhesion, aggregation, platelet secretion, platelet procoagulant activity, combined abnormalities of number and function), plus acquired platelet dysfunction disorders (from a variety of medical conditions and drugs). (nicklauschildrens.org)
  • The aim of this study was to characterize and extensively evaluate long-term liver involvement in MMA and PA patients.We first describe four patients who had severe liver involvement during the course of their disease. (stanford.edu)
  • Within male factor infertility, 1% had normospermia/absence of any urological abnormality,15% of males were diagnosed with mild to moderate oligospermia, 5% with severe sperm defects like oligospermia, oligo-asthenospermia, azoospermia or aspermia or teratozoospermia and 2% with untreated other urological conditions like unilateral or bilateral varicoceles, hydroceles. (thefreedictionary.com)
  • Based on these acquisitions, several epigenetic investigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. (bvsalud.org)
  • Affected individuals can have a wide variety of signs and symptoms, but the most common are sparse scalp hair, small head size (microcephaly), distinct facial features, short stature, prominent finger joints, unusually short fingers and toes (brachydactyly), recurrent seizures (epilepsy), and moderate to severe intellectual disability with impaired language development. (malacards.org)
  • Patients with severe RHF requiring right ventricular assist device support had a low success of bridge to transplantation (11.1% vs 33.3%, p = 0.02). (uah.edu)
  • A primary central nervous system lymphoma ( PCNSL ), also known as microglioma and primary brain lymphoma , is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS ). (wikipedia.org)
  • Parent-reported HRQoL fell within a previously defined range for healthy children in 37.5% of patients, and for children with severe health conditions in 45% of patients. (bvsalud.org)
  • A 32 year old man with symptoms of an upper respiratory infection one week prior presented with mental status changes and a severe occipital headache of two days duration. (yassermetwally.com)