Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Radiation, Ionizing: ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Radiation Tolerance: The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.Radiation: Emission or propagation of acoustic waves (SOUND), ELECTROMAGNETIC ENERGY waves (such as LIGHT; RADIO WAVES; GAMMA RAYS; or X-RAYS), or a stream of subatomic particles (such as ELECTRONS; NEUTRONS; PROTONS; or ALPHA PARTICLES).Radiation ProtectionRadiation Monitoring: The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Cosmic Radiation: High-energy radiation or particles from extraterrestrial space that strike the earth, its atmosphere, or spacecraft and may create secondary radiation as a result of collisions with the atmosphere or spacecraft.Radiation Injuries, Experimental: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Gamma Rays: Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Background Radiation: Radiation from sources other than the source of interest. It is due to cosmic rays and natural radioactivity in the environment.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Radiation Effects: The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Abnormalities, MultipleRadiation-Sensitizing Agents: Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Radiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Acute Radiation Syndrome: A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.Radioactive Hazard Release: Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.X-Rays: Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.Cobalt Radioisotopes: Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.Radiobiology: Study of the scientific principles, mechanisms, and effects of the interaction of ionizing radiation with living matter. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Radiotherapy, Conformal: Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.Radiation Hybrid Mapping: A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Dose Fractionation: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Congenital Abnormalities: Malformations of organs or body parts during development in utero.Linear Energy Transfer: Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T).Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Chromosome Disorders: Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)Karyotyping: Mapping of the KARYOTYPE of a cell.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Radiation Genetics: A subdiscipline of genetics that studies RADIATION EFFECTS on the components and processes of biological inheritance.Leukemia, Radiation-Induced: Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Nuclear Warfare: Warfare involving the use of NUCLEAR WEAPONS.Abnormalities, Radiation-Induced: Congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation.Eye Abnormalities: Congenital absence of or defects in structures of the eye; may also be hereditary.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Body Burden: The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.Synchrotrons: Devices for accelerating protons or electrons in closed orbits where the accelerating voltage and magnetic field strength varies (the accelerating voltage is held constant for electrons) in order to keep the orbit radius constant.Radiation, Nonionizing: ELECTROMAGNETIC RADIATION or sonic radiation (SOUND WAVES) which does not produce IONS in matter through which it passes. The wavelengths of non-ionizing electromagentic radiation are generally longer than those of far ultraviolet radiation and range through the longest RADIO WAVES.Relative Biological Effectiveness: The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.Fluoroscopy: Production of an image when x-rays strike a fluorescent screen.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Electromagnetic Radiation: Waves of oscillating electric and MAGNETIC FIELDS which move at right angles to each other and outward from the source.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Particle Accelerators: Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.Cesium Radioisotopes: Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes.DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Radiography: Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film).Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Sunlight: Irradiation directly from the sun.Thermoluminescent Dosimetry: The use of a device composed of thermoluminescent material for measuring exposure to IONIZING RADIATION. The thermoluminescent material emits light when heated. The amount of light emitted is proportional to the amount of ionizing radiation to which the material has been exposed.Technology, Radiologic: The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.Beta Particles: High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Nuclear Weapons: A weapon that derives its destructive force from nuclear fission and/or fusion.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Radioactive Fallout: The material that descends to the earth or water well beyond the site of a surface or subsurface nuclear explosion. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)Solar Activity: Any type of variation in the appearance of energy output of the sun. (NASA Thesaurus, 1994)Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Chernobyl Nuclear Accident: April 25th -26th, 1986 nuclear power accident that occurred at Chernobyl in the former USSR (Ukraine) located 80 miles north of Kiev.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Radiotherapy, High-Energy: Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Syndrome: A characteristic symptom complex.Radioisotopes: Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Cardiovascular Abnormalities: Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.Cranial Irradiation: The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.Infrared Rays: That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.Radiography, Interventional: Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.Heavy Ions: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Film Dosimetry: Use of a device (film badge) for measuring exposure of individuals to radiation. It is usually made of metal, plastic, or paper and loaded with one or more pieces of x-ray film.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Radiotherapy, Computer-Assisted: Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)UkraineMice, Inbred C57BLHealth Physics: The science concerned with problems of radiation protection relevant to reducing or preventing radiation exposure, and the effects of ionizing radiation on humans and their environment.Breast Neoplasms: Tumors or cancer of the human BREAST.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Skin Abnormalities: Congenital structural abnormalities of the skin.Cell Line, Tumor: A cell line derived from cultured tumor cells.Infant, Newborn: An infant during the first month after birth.Scattering, Radiation: The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Phantoms, Imaging: Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)Nuclear Reactors: Devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Urogenital Abnormalities: Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.Cobalt Isotopes: Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Trisomy: The possession of a third chromosome of any one type in an otherwise diploid cell.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Tooth Abnormalities: Congenital absence of or defects in structures of the teeth.Musculoskeletal Abnormalities: Congenital structural abnormalities and deformities of the musculoskeletal system.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Radioactive Pollutants: Radioactive substances which act as pollutants. They include chemicals whose radiation is released via radioactive waste, nuclear accidents, fallout from nuclear explosions, and the like.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Whole-Body Counting: Measurement of radioactivity in the entire human body.Radiotherapy, Image-Guided: The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Organs at Risk: Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Alpha Particles: Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Nuclear Medicine: A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Radiation Chimera: An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Aneuploidy: The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).Power Plants: Units that convert some other form of energy into electrical energy.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Radiography, Thoracic: X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Bystander Effect: The result of a positive or negative response (to drugs, for example) in one cell being passed onto other cells via the GAP JUNCTIONS or the intracellular milieu.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Ataxia Telangiectasia Mutated Proteins: A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Proctitis: INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.Radioimmunotherapy: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).Sex Chromosome Aberrations: Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.Cytogenetic Analysis: Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.Solar Energy: Energy transmitted from the sun in the form of electromagnetic radiation.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Food Irradiation: Treatment of food with RADIATION.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Skin Neoplasms: Tumors or cancer of the SKIN.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Iridium Radioisotopes: Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.Microwaves: That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Cytogenetics: A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.Genetic Speciation: The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Space Flight: Travel beyond the earth's atmosphere.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.Pelvic Neoplasms: Tumors or cancer of the pelvic region.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Mice, Inbred C3HRadiation Leukemia Virus: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from radiation-induced lymphomas in C57BL mice. It is leukemogenic, thymotrophic, can be transmitted vertically, and replicates only in vivo.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.

Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe. EUROCAT Working Group. (1/64)

BACKGROUND: Surveillance data from population-based congenital anomaly registers in 16 regions of Europe (mainly Western Europe) were analysed to assess the impact of the Chernobyl accident on the prevalence of selected congenital anomalies. METHODS: Three cohorts of pregnancies were defined: those exposed during the first month following Chernobyl (External Exposure Cohort), the first year (Total Exposure Cohort) and the two subsequent years (Control Cohort). Expected numbers of congenital anomalies in these cohorts were calculated from 1980-1985 baseline rates. Registries were grouped into three exposure categories according to first-year exposure estimates. RESULTS: There was no overall or dose-related increase in prevalence in the two exposed cohorts for Down's Syndrome, neural tube defects, other central nervous system defects or eye defects. There was a statistically significant overall 22% (95% CI: 13-31%) excess of Down's Syndrome in the Control Cohort, with no dose-response relationship. CONCLUSIONS: Chernobyl had no detectable impact on the prevalence of congenital anomalies in Western Europe, suggesting that in retrospect the widespread fear in the population about the possible effects of exposure on the unborn fetus was not justified. An increasing prevalence of Down's Syndrome in the 1980s, probably unrelated to Chernobyl, merits further investigation.  (+info)

Reduced inhibition in an animal model of cortical dysplasia. (2/64)

Cortical dysplasia has a strong association with epilepsy in humans, but the underlying mechanisms for this are poorly understood. In utero irradiation of rats produces diffuse cortical dysplasia and neuronal heterotopia in the neocortex and hippocampus. Using in vitro neocortical slices, whole-cell patch-clamp recordings were obtained from pyramidal neurons in dysplastic cortex and control neocortex. Spontaneous IPSCs were reduced in amplitude (35%) and frequency (70%) in pyramidal cells from dysplastic cortex. Miniature IPSCs were reduced in frequency (66%) in dysplastic cortex. Two additional measures of cortical inhibition, monosynaptic evoked IPSCs and paired pulse depression of evoked EPSCs, were also impaired in dysplastic cortex. Spontaneous EPSCs were increased in amplitude (42%) and frequency (77%) in dysplastic cortex, but miniature EPSCs were not different between the two groups. These data demonstrate significant physiological impairment in inhibitory synaptic transmission in experimental cortical dysplasia. This supports previous immunohistochemical findings in this model and observations in humans of a reduction in the density of inhibitory interneurons in dysplastic cortex.  (+info)

Maintaining a proper perspective of risk associated with radiation exposure. (3/64)

OBJECTIVES: The objectives of this article are to provide the reader with (a) a brief discussion of actual, perceived, and acceptable risks associated with radiation exposure; (b) a basic review of radiation protection units and a discussion as to how these units are used to estimate risk associated with occupational radiation exposure; (c) a summary of radiation doses required for specific human biologic responses and a comparison of relative doses encountered in a variety of clinical situations; and (d) a practical approach to discussing relative risks associated with medical radiation exposures when patients inquire.  (+info)

Dependence of malformation upon gestational age and exposed dose of gamma radiation. (4/64)

In order to evaluate the importance of gestational age and the dose-incidence relationship by gamma radiation, pregnant ICR mice at gestational days from 2.5 to 15.5 days post-coitus (p.c.) were exposed to a single dose of 2.0 Gy and also at day 11.5 after conception, which was the most sensitive stage for the induction of major congenital malformations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, changes in head size and other morphological abnormalities. The only demonstrable effect of irradiation during the pre-implantation period was an increase in prenatal mortality. Resorptions were maximal on exposure at day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. A small head, growth retardation, a cleft palate, dilatation of the cerebral ventricle, a renal pelvis, and abnormalities of the extremities and tail after exposure were prominent during the organogenesis period, especially on day 11.5 of gestation. As for the dose-incidence relationship, the incidence of a small head, growth-retarded fetuses, a cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose as the radiation dose increased. The result indicated that the late period of organogenesis in the development of the brain, skull and extremities of a mouse was a particularly sensitive phase. The threshold doses of radiation that induced a cleft palate and dilatation of the cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.  (+info)

The combined effects of MRI and X-rays on ICR mouse embryos during organogenesis. (5/64)

The combined effects of X-rays and magnetic resonance imaging (MRI) on mouse embryos at an early stage of organogenesis were investigated. Pregnant ICR mice were irradiated on day 8 of gestation with X-rays at a dose of 1 Gy and/or MRI at 0.5 T for 1 hour. The mortality rates of the embryos or fetuses, the incidence of external malformations, the fetal body weight and the sex ratio were observed at day 18 of gestation. A significant increase in embryonic mortality was observed after exposure to either 1 Gy of X-radiation or 0.5 T MRI. However, the combined X-rays and MRI did not show a statistically significant increase in embryonic mortality compared with the control. External malformations, such as exencephaly, a cleft palate and anophthalmia, were observed in mice irradiated with X-rays and/or MRI. The incidence of each malformation in all treated groups increased with statistical significance compared with the control mice. The incidence in mice irradiated with both X-rays and MRI was lower than in mice irradiated with only X-rays. The combined effects of the combination of radiation and MRI on the external malformations might be antagonistic. There were no statistically significant differences in fetal death, fetal body weight and sex ratio among all experimental groups.  (+info)

Effects of a 4.7 T static magnetic field on fetal development in ICR mice. (6/64)

In order to determine the effects of a 4.7 T static magnetic field (SMF) on fetal development in mice, we evaluated fetal teratogenesis and endochondral ossification following exposure in utero. Pregnant ICR mice were exposed to a 4.7 T SMF from day 7.5 to 9.5 of gestation in a whole-body dose, and sacrificed on day 18.5 of gestation. We examined the incidence of prenatal death, external malformations and fetal skeletal malformations. There were no significant differences observed in the incidence of prenatal death and/or malformations between SMF-exposed mice and control mice. Further, we evaluated the immunoreactivity for the vascular endothelial growth factor (VEGF), which is implicated in angiogenesis and osteogenesis, in the sternum of fetal mice following magnetic exposure. Our studies also indicated that on day 16.5 of gestation following SMF exposure, the immunoreactivity for VEGF was increased compared to unexposed controls. However, it was decreased in the exposed group compared to the control group on day 18.5 of gestation. DNA and proteoglycan (PG) synthesis were also measured in rabbit costal growth plate chondrocytes in vitro. No significant differences were observed in DNA synthesis between the SMF exposed chondrocytes and the control chondrocytes; however, PG synthesis in SMF exposed chondrocytes increased compared to the controls. Based on these results, we suggest that while SMF exposure promoted the endochondral ossification of chondrocytes, it did not induce any harmful effects on fetal development in ICR mice.  (+info)

Model prediction of treatment planning for dose-fractionated radioimmunotherapy. (7/64)

BACKGROUND: Clinical trials of radioimmunotherapy (RIT) often use dose fractionation to reduce marrow toxicity. The dosing scheme can be optimized if marrow and tumor cell kinetics following radiation exposure are known. METHODS: A mathematic model of tumor clonogenic cell kinetics was combined with a previously reported marrow cell kinetics model that included marrow stromal cells, progenitor cells, megakaryocytes, and platelets. Reported values for murine tumor and marrow cellular turnover rates and radiosensitivity were used in the model calculation. RESULTS: Given a tolerated level of thrombocytopenia, there is a fractionation scheme in which total radioactive dose administration can be maximized. Isoeffect doses that had different numbers of fractions and total radioactivity, but induced identical platelet nadirs of 20%, were determined. Assuming identical tumor uptake for all dose fractions, six tumor types were examined: early-responding tumors, late-responding tumors, and tumors that lacked a late-responding effect, with either constant or accelerated doubling time. For most tumor types, better tumor control (tumor growth delay and nadir of survival fraction) was predicted for a dosing scheme in which total radioactive dose was maximized. For late-responding tumors with accelerated doubling time, tumor growth delay increased, but the nadir of survival fraction became shallower as the number of fractions increased. CONCLUSIONS: A mathematic model has been developed that allows prediction of the nadir and duration of thrombocytopenia as well as tumor clonogenic cell response to various RIT doses and fractionation schemes. Given a maximum tolerated level of thrombocytopenia, the model can be used to determine a dosing scheme for optimal tumor response.  (+info)

Elevated minisatellite mutation rate in the post-chernobyl families from ukraine. (8/64)

Germline mutation at eight human minisatellite loci has been studied among families from rural areas of the Kiev and Zhitomir regions of Ukraine, which were heavily contaminated by radionuclides after the Chernobyl accident. The control and exposed groups were composed of families containing children conceived before and after the Chernobyl accident, respectively. The groups were matched by ethnicity, maternal age, parental occupation, and smoking habits, and they differed only slightly by paternal age. A statistically significant 1.6-fold increase in mutation rate was found in the germline of exposed fathers, whereas the maternal germline mutation rate in the exposed families was not elevated. These data, together with the results of our previous analysis of the exposed families from Belarus, suggest that the elevated minisatellite mutation rate can be attributed to post-Chernobyl radioactive exposure. The mechanisms of mutation induction at human minisatellite loci are discussed.  (+info)

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KD on pace to break MJs playoff scoring record of 63 pts with 38 pts in the 1st half seems an appropriate time to post a thread about all the rumors that its a done deal that he signs with the Knicks. Check out this fans YouTube video explaining why hes coming to the Knicks. Xgl0HXRR32o Or Ian Begleys ESPN story on him coming. http://www.espn.com/nba/story/_/id/26599267/the-knicks-won-tank-race-now-need-little-luck Huge signing for Mills/Perry, sign him others will follow whether
Pregnant ICR mice (Nihon-SLC) were used for in utero electroporation. Noon of the day at which the vaginal plug was detected was designated as embryonic day 0.5 (E0.5) and E19.5 was defined as P0.5. In utero electroporation was conducted on E13.5-13.75 embryos as described previously (Hatanaka et al., 2004) with minor modifications. Briefly, a 1-1.5 μl plasmid solution was injected into the lateral ventricle and 30 V or 40 V electric pulses of 50 ms duration were delivered at 200 ms intervals. Plasmids were prepared with the NucleoBond Midi Kit (Macherey-Nagel), suspended in PBS (0.1 m, pH 7.4) and electroporated at the following final concentrations: 1.0 μg/μl pCAG-EGFP-IRES-mito-mCherry for analysis of the mitochondrial distribution during the development of dendritic arbors; 3.0 μg/μl pCAG-Mfn1 and 1.0 μg/μl pCAG-EGFP-IRES-mito-mCherry for analysis of the mitochondrial distribution and dendritic morphology in Mfn1-overexpressing neurons; 3.0 μg/μl pCAG-Mfn1 and 1.0 μg/μl ...
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Purpose of the group: To support the safe use of medicines by radiographers and associated professionals in clinical imaging and radiotherapy services
Radiographers undertaking this work not only have highly specialist skills in imaging modalities, but are experienced in the care and techniques required for scanning acutely ill patients who require urgent assessment during a critical period of the care pathway. Additionally, they may also have the advanced practitioner skills to review and report the images obtained to help
Concerning the widespread use of X-rays to detect various diseases, such as oral and dental ones, it is essential to study the effects of this radiation on living cells. From the past, ge- netic effects and cell death because of X-rays have been studied. In addition, the effect of this ionizing...
A woman told police she was getting out of her car at The Residence at Kensington Place when a man approached her with a gun and grabbed her purse.
by the way, everybody, with the sudden, tragic death of hot town, vince has taken up temporary residence at mandible claw, where he can let out his grieving through witty, informational posts. please let him into your hearts ...
An iconic hotel in the heart of midtown Manhattan is buzzing with thousands of tiny new visitors. But watch out: Theyll sting if you get too close. Honeybees have taken up residence at the Waldorf-A
Zac Stacy heads for X-rays on left ankle If you play fantasy sports, get breaking news and immerse yourself in the ultimate fan experience.
Altedo di Malalbergo on the route between Bologna and Ferrara is where the practice of Diverserighe (architects Simone Gheduzzi, Nicola Rimondi and Gabriele Sor
Hi I had given an old CRT-based rear-projection TV, which I dissasembled. But before doing so I opened it and operated it a few times (total 30 minutes or...
FWIW, my dentist knows that I and my family do not want excessive x-rays. Before taking any x-rays, we are asked whether it is ok and I have never felt in any way forced to submit to x-rays. The dentist I went to before my current one was very agitated when I refused x-rays on a six month basis for my 3 year old and made me sign a release absolving the practice of any responsibility for missed problems. I found a new dentist after that happened ...
What is the possible cause for afternoon (2-7:00 pm) slight fever, around 99.2-99.9? It has been last for more than one month after contracted a flu and I had taken 2 doses of antibiotic each for 5 days. Had x-ray on lung showing a 3mm pos
This course provides a survey of disease processes significant to the radiographer, including etiology, diagnosis, prognosis, and treatment.. ...
This study aimed to evaluate the accuracy of radiographers screen-reading mammograms. Currently, radiologist workforce shortages may be compromising the BreastScreen Australia screening program goal to detect early breast cancer. The solution to a similar problem in the United Kingdom has successfully encouraged radiographers to take on the role as one of two screen-readers. Prior to consideration of this strategy in Australia, educational and experiential differences between radiographers in the United Kingdom and Australia emphasise the need for an investigation of Australian radiographers screen-reading accuracy. Ten radiographers employed by the Westmead Breast Cancer Institute with a range of radiographic (median = 28 years), mammographic (median = 13 years) and BreastScreen (median = 8 years) experience were recruited to blindly and independently screen-read an image test set of 500 mammograms, without formal training. The radiographers indicated the presence of an abnormality using ...
The NHS in NW London took a day out to support and encourage radiographers to reach their career goals and aspirations, at our Diagnostic Radiographer Education Day on Saturday 28 January. Radiographers and radiography students joined inspirational speakers from across NW London to discuss careers in radiography and emerging technology. There were also opportunities to network with the leadership teams from trust imaging departments.
Principal Investigator:YAMAMOTO Hiroshi, Project Period (FY):1998 - 1999, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:電磁場環境
Until about a decade ago, the substructures seen in the Balmer-line profiles of active stars were generally regarded as too complex for quantitative study. Since then, however, detector technology has improved to the point where we can monitor the evolution of these structures with temporal sampling rates high enough to allow us to see coherent patterns in the data. Although some of the patterns that have emerged from such studies are consistent with stochastic flare activity, a large part of the complex substructure seen in the Balmer lines appears to be caused by mass motions of clumps of Balmer emitting and absorbing material. As these clumps are embedded in the much hotter ambient medium of the stellar corona, they are usually dubbed ``prominences" by analogy to solar prominences. Some of the mass motions seen in association with stellar flares are transient, and appear to resemble the prominence eruptions seen on the Sun in connection with coronal mass ejections and two-ribbon flares. ...
When compared to other common cancers, lung cancer patients are less likely to survive their cancer. This is often due to a delay in the recognition of the condition and performance of the chest X-ray (CXR). Delayed diagnosis reduces treatment choices because the cancer may have spread further and the person may have become too ill for treatment to be given safely. It is hoped that by diagnosing lung cancer sooner this will help improve survival, help with patient satisfaction and potentially extend the range of treatment options, which are more limited in delayed diagnosis. CXRs are often used when lung cancer is suspected, but there can be long delays for the results to be available to the patient and the GP. Radiographers traditionally take the X-ray, but they are reported by a radiologist, a medical specialist. Recent studies show that radiographers who have completed further training can report CXRs with similar accuracy to radiologists. This project will help to reduce delays in diagnosis ...
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system - Q07.9
Metamorphic Congenital Malformation lyrics by Cephalotripsy: Scourging paths of the impermissible / Descending upon dwellings of those
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Unknown gunmen have abducted a 14-year-old girl in Kankia local government area of Katsina State. Father of the victim, Alhaji Salisu Mai-Tiles, said the gunmen invaded his residence at Sabuwar-Abuja quarters in Kankia at 1:30 a.m. on Thursday. He said that three well- armed persons broke into his residence and demanded for money, while the remaining gang members stayed outside. "They asked me to give them money, which I did; whatever they asked we never objected to their demand to… Read more ...
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Both Becketts and Enos plays are filled with a wicked sense of humor.What separates both authors from their contemporaries, however, is their profound depth. Their work burrows down into the most intimate vulnerabilities of the human soul. With both writers, at one moment I am laughing myself to the floor and the next I feel as though I am having an epiphany. What makes Eno a Samuel Beckett for the Jon Stewart generation is that he is so much of our time. Just as Beckett exploited the forms of slapstick comedy, vaudeville, and silent movies, Eno puts his profound ideas in the forms of stand-up comedy and the 24-hour news cycle. The fact that he is able to tackle such weighty themes in these forms is exactly what makes his work so surprising and catches us off guard. He is one of the most exciting playwrights alive today and having him in residence at Cutting Ball this March is an extraordinary treat ...
Using a custom build spectrophotometer equipped with Helmholtz coils and designed to study the effects of magnetic fields on enzyme reactions in real-time we have investigated the influence of fields, from 100 ?T to 10 mT and at a variety of field frequencies, on the membrane bound enzymes alkaline phosphatase and acetylcholinesterase. We have also employed other methods to apply a magnetic field, e.g. Biostim. In contrast to earlier reports we have been unable to detect any field effects on these enzymes under any field/frequency regime. We discuss possible reasons for the discrepancy between this and earlier work and note the particularly complex influence of small temperature changes that may confound analysis.. ...
Q00-Q99 - Congenital malformations of the circulatory system; Congenital malformations of the respiratory system; Cleft lip and cleft palate; Other congenital malformations of the digestive system; Congenital malformations of genital organs; Congenital malformations of the urinary system; Congenital malformations and deformations of the musculoskeletal system; Other congenital malformations; Chromosomal abnormalities, not elsewhere classified: Diseases and Medical Conditions (ICD-10) from Drugs-about.com
Yang, T C.; Howard, J; Craise, L; and Tobias, C A., "Effects of energetic silicon ions, u.v. Radiation and x-rays on neoplastic cell transformation and mutation. Abstr." (1982). Subject Strain Bibliography 1982. 4006 ...
MRI Radiographer Job: We are working in partnership with the Sidra Medicine. Our client is an ultramodern, all-digital academic medical centre specialising in the provision of care | Cavendish Recruitment
The average radiographer industrial salary in Arkansas, United States is $45,025 or an equivalent hourly rate of $22. Salary estimates based on salary survey data collected directly from employers and anonymous employees in Arkansas, United States.
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21: Mostafa, R.M., A.L.H. El Hefnawi, K.M. Moustafa, F.M. Ali, Y.M. Moustafa, S. Kamal and M.H. El Hefnawi, 2007. Effect of 50 Hz, 10 mTesla magnetic field on sex hormones level in male rats. J. Med. Sci. Res., 1: 31-36. ...
When our class studies the letter X we make hand x-rays on black construction paper by tracing around each students hand with white chalk, then painting the
We all stood in perplexed silence for a moment. I looked at the chest X-ray on the box in front of me and systematically began to analyze it. Based on the size of the chest it looked like an adult, probably male since no breast shadows were evident. Good quality film, no rotation. Heart normal size. Lungs… Something about the lungs. They were clear for the most part: Black fields indicating that the X-rays were going clear through the mostly-air of the lungs to expose the film behind, blocked at regular intervals by the gentle white arcs of ribs bordering and encircling the chest. But in the blackness where there should be nothing - more white, something, some things, in the lungs blocking the X-rays, things that looked like huge cotton balls. "Fluffy infiltrates" is the term radiologists use for lesions such as these. I thought I could rattle off a few things that did this, but it would help to know more about this patient. I knew my place so the resident was the one who asked the question ...
BOTEJUE - LESLY. (Retired Sri Lanka Tourist Board). Loving husband of Yvonne (retired Peoples Bank),​ brother of Pearl,​ late Preeni and Anton,​ brother-in-law of Peter,​ Geetha,​ Shiranthi,​ Padmini and Chandrakumari. Remains lie at No. 17,​ Mendis Avenue,​ Idama,​ Moratuwa. Cortege leaves residence at 4.00 p.m. on Friday 15th December 2017 for burial at the General Cemetery (Anglican Section),​ Holy Emmanuel Church,​ Idama,​ Moratuwa at 4.30 p.m.155960
23 May, 2017. A search warrant executed by Police on Wednesday 17 May 2017 at a residence at Kolomotua, resulted in the arrest of a 45 year old...
Im currently the Artist in Residence at The Arts & Genomics Center in Leiden, the Netherlands. Im working on a project to create a dynamic display made of fluorescent bacteria.. biodisplay.tyrell.hu/ ...
Every July, around 10 Canadian universities scattered across the country play host to 500 students from all provinces/territories and even internationally. Although the program is for open-minded high school students who are not afraid to delve into any subject and become challenged or inspired in ways they never thought possible in one month, I hope to break the stereotype that this is nerd camp. My program consisted of 56 total Shads and we lived in residence at the university ...
... is a congenital malformation in which the uterus has an irregular shape that is divided into two so-called horns, two separate cavities that
Read "Effects of Weak Environmental Magnetic Fields on the Spontaneous Bioelectrical Activity of Snail Neurons, The Journal of Membrane Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
D.C. United dodged a preseason scare when X-rays on midfielder Danny Cruzs ankles were negative.D.C. United dodges a preseason scare when X-rays on midfielder Danny Cruzs ankles were negative.D.C. United dodged a preseason scare when X-rays on midfielder Danny Cruzs ankles were negative.
The undergraduate to graduate program allows Coe students to complete their Bachelor of Arts (B.A.) and Master of Public Health (MPH) at the University of Iowa in five years. Students will spend four years in residence at Coe, followed by a summer course (online), and one academic year in residence at the University of Iowa College of Public Health. Coe students will take a total of four MPH courses at Coe. These courses can be taken at the University of Iowa or through web-based course offerings. Students from any major at Coe can apply and be considered for admission to the MPH program.. ...
- 23,95Eur - Belarus. Bielorrusia. Idioma: INGL S. Autor: Nigel Roberts. 2 EDICI N. FEBRERO 2011. 272 P GINAS. 16 P GINAS DE FOTOS A COLOR. 21 MAPAS. ISBN: 9781841623405. Mysterious and misunderstood, Belarus remains an enigma at the heart of Europe. Bradts Belarus gives you all the information needed to get the best from this lost world. Explore Minsk, Belaruss modern city, built
Effects of dc and low-frequency ac magnetic fields on the motion and distribution of counterions on surfaces of cylindrical biological cells are examined. Magnetic fields along the cell axis as well...
The Cohen lab develops physical tools to study molecules and cells. We work on imaging voltage in brains, hearts, embryos, and microorganisms; we study DNA mechanics; we study the effects of weak magnetic fields on chemical reactions; and we study the fundamental physics of light-matter interactions.
If we write this in component form it becomes (∂Bx/∂x)i + (∂By/∂y)j + (∂Bz/∂z)k = 0, where i, j, k are unit vectors in a cartesian coordinate system and Bx, By, Bz are the components of the magnetic field on these axes ...
Congenital malformations occur frequently in the nervous system and are exceeded only by prematurity as a cause of death in infants.
An MRI scanner is a short tunnel which is open at both ends. During the procedure, you lie on a motorised bed, which is moved inside the scanner.. A small receiving device is placed behind or around the part of your body being scanned. You are moved into the scanning tube, either head- or feet-first, depending on which part of your body is being scanned.. A computer is used to operate the MRI scanner. The computer is located in a different room to the scanner to keep it away from the magnetic field generated by the scanner.. As the radiographer operates the computer, they will also be in a separate room to you. You will hold a bell in your hand during the scan and if you need to talk to the radiographer you can ring the bell and talk to them via the intercom. The radiographer will be able to see you at all times on a television monitor.. During your scan, a friend or family member may be allowed to stay in the room with you. Children can usually have a parent with them. Anyone who stays in the ...
Ellen Johnson Sirleaf Born: 29 October 1938 Residence at the time of the award: Liberia Prize motivation: for their non-violent struggle for the safety of women and for womens rights to full participation in peace-building work Role: President of Liberia
Police on Tuesday arrested a 20-year-old Montville man on charges connected to a fire that burned a vacant residence at 346 Salem Turnpike.
PITTSBURGH -- Pirates third baseman Jung Ho Kang left Saturdays 5-1 loss to the Rockies after five innings due to discomfort in his left hand. He is day to day, the club announced. An X-ray on Kangs injured left hand revealed no fractures, he said.
Vancouver Sports Chiropractor located in Kitsilano. Family Chiropractic/Sports injury specialist,with Registered Massage Therapy & X-Rays on site.604-731-6679
Vancouver Sports Chiropractor located in Kitsilano. Family Chiropractic/Sports injury specialist,with Registered Massage Therapy & X-Rays on site.604-731-6679
The CT scanner is a large ring-shaped machine. You will be asked to lie on a motorised bed that moves in and out of the hole. Only the part of your body that is inside the ring can be scanned.. Your radiographer will position the bed so that the correct part of your body is in the scanner. They will then leave the room and operate the scanner from a control room behind a window. This is because it is dangerous for staff to be exposed to X-rays every day. You will still be able to hear and speak to the radiographer during the procedure through an intercom.. You will be asked to lie very still and breathe normally while each scan is taken, to avoid blurring the images. You may be asked to inhale, exhale or hold your breath at certain points.. The X-ray unit inside the ring will rotate around you. Each time it goes round it creates a new X-ray scan. After each X-ray is completed, the bed on which you are lying is moved forward a small amount.. Several scans will be carried out and the whole ...
First - we want to make sure that you are fully informed. Please do call us if you have any questions before your appointment. If certain medical terms arent clear, we will happily explain them to you. If youd like to bring a friend or family member for support, that is no problem but they may not be able to stay with you during the scan dependent on the procedure and safety screening. Children will not be allowed into the scan room while you are having the scan... At your appointment, you will meet your Nuffield Health Radiographer - an expert in MRI scanning. Your Radiographer will be with you through the whole process, from explaining the scan and answering your questions beforehand, to performing the actual scan on the day.. ...
Belarusian President Alyaksandr Lukashenka (file photo) (AFP) October 24, 2006 -- Belarus wants to improve relations with the United States, Belarusian President Alyaksandr Lukashenka today told th...
Radiographers are highly skilled professionals qualified by education to perform imaging examinations and accompanying responsibilities at the request of a physician. A radiographer is able to perform diagnostic imaging, fluoroscopy, trauma, surgical, and portable radiography.
Free, official coding info for 2018 ICD-10-CM Q21.8 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
This page was last edited 05:31, 3 May 2008 by [email protected] Based on work by wikidoc anonymous users Lisatwo and Arcadian ...
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We have theoretically studied the combination effects of the electric and magnetic fields on the binding energy of an on-center donor impurity in disc-shaped GaAs/Al0.3Ga0.7As quantum dots (QDs) with emphasis on the competition effects between the two fields under externally applied pressure and temperature. The electric field is applied along the radial direction of the QD, while the magnetic field is applied along the growth direction. The numerical method we employed in the present calculations is the potential morphing method in the framework of the effective mass approximation. Our results show that the two fields exhibit a competition effect on the donor binding energy, leading to an invariant binding energy as in the zero field case at a critical line. This line separates the region corresponding to the "red shift" of the donor binding energy from the one referring to the "blue shift" of the binding energy. Comparing to the magnetic field effect, increasing in the QD sizes or applied ...
Under a magnetic field the activities of superoxide dismutase (SOD) in vitro and in vivo and accompanying activities of catalase activity in vivo were investigated in soybean roots. In plant cells a magnetic field creates a stress condition as other environmental stress factors do. To...
Magnetic freezing is nowadays established as a commercial reality mainly oriented towards the food market. According to advertisements, magnetic freezing is able to generate tiny ice crystals throughout the frozen product, prevent cell destruction, and preserve the quality of fresh food intact after thawing. If all these advantages were true, magnetic freezing would represent a significant advance in freezing technology, not only for food preservation, but also for cryopreservation of biological specimens such as cells, tissues, and organs. Magnetic fields (MFs) are supposed to act directly on water by orientating, vibrating, and/or spinning molecules to prevent them from clustering and, thus, to promote supercooling. However, many doubts exist about the real effects of MFs on freezing and the science behind the potential mechanisms involved. To provide a basis for extending the understanding of magnetic freezing, this paper presents a critical review of the materials published in the literature ...
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Belarus, country of eastern Europe. Until it became independent in 1991, Belarus, formerly known as Belorussia or White Russia, was the smallest of the three Slavic republics included in the Soviet Union (the larger two being Russia and Ukraine). Learn more about the history and culture of Belarus in this article.
Over recent years, our working group has implemented the complete data processing chain for PET within the framework of the simulation platform GATE. This contribution has been the backbone of ongoing detector development and also for the complete design of complex systems. In addition to this, simulation is being used extensively during the development of novel fast reconstruction algorithms and, owing to the availability of ever more powerful computing systems (CPU/GPU), even very complex systems can now be simulated under various aspects. This includes the precise consideration and implementation of all physical effects, especially all types of interactions photons undergo in the surrounding material, and also includes the effect of strong magnetic field on the distribution of the positrons in hybrid devices as MR-PET.. For our studies we use the simulation package GATE, which was developed by the OpenGATE Collaboration (http://www.opengatecollaboration.org/home) and is based on GEANT4 (CERN) ...
Context. Capella is among the few binary stars with two evolved giant components. The hotter component is a chromospherically active star within the Hertzsprung gap, while the cooler star is possibly helium-core burning. |BR /| Aims: The known inclination of the orbital plane from astrometry in combination with precise radial velocities will allow very accurate masses to be determined for the individual Capella stars. This will constrain their evolutionary stage and possibly the role of the active stars magnetic field on the dynamical evolution of the binary system. |BR /| Methods: We obtained a total of 438 high-resolution échelle spectra during the years 2007-2010 and used the measured velocities to recompute the orbital elements. Our double-lined orbital solution yields average residuals of 64 m s|SUP|-1|/SUP| for the cool component and 297 m s|SUP|-1|/SUP| for the more rapidly rotating hotter component. |BR /| Results: The semi-amplitude of the cool component is smaller by 0.045 km s|SUP|-1|/SUP|
The Office Office has 10 ops Play room for kids Environmentally friendly design Fully digital office with electronic charts Cool play area for your kids Panoramic X-ray unit with minimal radiation A view of your X-rays on TVs in treatment room Refreshment bar Dental chair with built-in massagers Automated text
A b s t r a c t Background: The most well known reproductive consequence of residence at high altitude (HA .2700 m) is reduction in fetal growth. Reduced fetoplacental oxygenation is an underlying cause of pregnancy ...
He checked the density in my breast and said in a nervous voice, "Lets go down the hall and get the mammogram". In a flurry of activity over the next hour, what remains so vivid in my memory was when they snapped the x-ray on the screen. No one needed to tell me what my own eyes saw. It was unmistakable. A child of five could have identified what looked like a snowball that had hit the x-ray, now hanging from the illuminated screen. No denials. No smiling faces. Sadness in the Radiologists eyes; and the color that had drained from the face of the young doctor, just out of med school. I knew. We all knew. Yet astonishingly, I told them it would be okay. I told them not to worry. I knew I would survive. I knew it, as well as I knew my own name. I dont know how, but I did. I could hear it echoing deep inside by body… I would survive, I would survive. ...
Mr. Stern holds a Bachelor of Fine Arts from the Philadelphia Academy of the Arts and a Master of Fine Arts from the University of Miami. He served as a filmmaker in residence at the North Carolina School of the Arts and as Adjunct Professor at New School University in New York.
Two new cards in, one each through Postcrossing and swap-bot. The card on the left--are those umbrellas?--comes to me from Belarus. The writer tells me these are names of the colors in the Belorussian language. She goes on to say that Belorussian is very poetic, and that some words even shock her! It makes me…
Free, official coding info for 2020 ICD-10-CM Q24.8 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Im a forensic radiographer, body and organ donor, and death education enthusiast who literally has a skeleton in her closet. Read more... ...
Belarusian touroperator offers: Travel to Belarus. Personal, group, skiing and other tours to Belarus. Hotel booking in Belarus. We offer a full variety of traveler`s solutions for Belarus. All hotels, destinations, medical, personal and other kinds of tours to Belarus.
Forget the Texas two-step. A two-headed Texas cooter turtle is the star of the San Antonio Zoo. From Time: The emerald green turtle, which arrived on June 18 and went on display Tuesday, has two noggins conjoined near the neck. Zoo officials...
These data from the Strasbourg Prospective Study of Congenital Malformations are reported in Congenital Malformations Worldwide: A Report from the International Clearinghouse for Birth Defects Monitoring Systems.. ...
EVALUATION OF EFFECTS OF INTERMEDIATE FREQUENCY MAGNETIC FIELD ON DNA METHYLATION. M. Ikehata1, S. Yoshie1, K. Wada2, Y. Suzuki2, K. Wake3, S. Nakasono4, M. Taki2, C. Ohkubo5. 1Biotechnology Laboratory, Human Science Division, Railway Technical Research Institute, Kokubunji, Tokyo, ...
Lookup HS Codes for Belarus xv 81.08.20 titanium raw; powders:. Avalara LandedCosts helps determine your duty rates and other import taxes for Belarus.
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This is the 4th and final article in this series on Military Records. You can read the first three in the series at Part 1, Part 2, and Part 3. These records can offer up quite a bit of information including your ancestors and collateral relatives vital statistics, birth date and location, residence at the…
Monday September 12, 2016. Board of Estimates. 4:30p room 260 MMB. https://madison.legistar.com/View.ashx?M=A&ID=443559&GUID=C38AE263-D3CB-409B-9EF8-E7CAE0CE0527. 14. 44203 Approving Facade Improvement Grant to Common Wealth Development Inc for a project located at 1406 Williamson Street. 20. 44225 Amending adopted RES-16-00359, Legislative File No. 42664 to authorize Information Technology to use the funds generated by donated computers/laptops sent to Cascade Asset Management to offset the setup and licensing costs of computers/laptops given to qualified subscribers in the Digital Divide Pilot areas. Darbo Worthington is part of the pilot.. 27. 44096 Authorizing the Purchase and Immediate Sale of Sid Boyums Residence at 237 Waubesa St.. Congrats to the Friends of Sid Boyum for raising the funds to purchase the house and preserve Sids amazing art.. 5. 44263 SUBSTITUTION Reaffirmation of Resolution Enactment No. RES-15-00334, File I.D. #37723 - Garver Selection Resolution. The resolution is to ...
ABSTRACT This study examines the effects of low dose x-rays on the pH, sperm count, and sperm motility of the epididymal sperm cells of wistar rats. An experimental survey (case control study design) was adopted and a purposive sampling technique was used to select the species of mammals used for the experiment while a convenient sampling technique was used to select a nearby animal farm and a simple random technique was used to select the population of the male rats used. The population.... ...
WASHINGTON -- Nationals outfielder Bryce Harper exited Fridays 11-1 victory over the Padres after four innings with a jammed left thumb. X-rays on Harpers thumb were negative, and manager Matt Williams said the outfielder will be re-evaluated Saturday.
Summary Orbis Research Presents Albertin Slonimsky Kartonno-Bumazhny Zavod OAO in Tissue and Hygiene (Belarus). Description Albertin Slonimsky Kartonno-Bu
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My first rabbinic position was as an assistant rabbi…. The rabbi [asked me] to daven Mussaf for the shul on the second day of Rosh ha-Shana. I was flattered… I went home, almost running the whole way, to tell my wife the good news… I immediately began practicing. I got tapes of various chazzanim and spent hours each day memorizing the tunes. I recorded myself so that I could hear how I sounded… My wife was enlisted to listen to Mussaf, over and over again. I had a friend in Yeshiva who was something of a Chazzan, and we spent time on the phone going over each tune I intended on using. In the end, I knew the entire Mussaf by heart, no small feat ...
  The present study aims at solving the problem of stagnant water due to receiving of sewage water in a lake at Eastern Jeddah, using state of the art safe techniques. Samples were collected from the lake, then treated using magnetic fields with different intensities in two states, static and shaking, for 30 days. Hence, the physical and chemical properties for samples were measured, in addition to their bacterial content. In both cases of static and shaking, increasing the magnetic flux density caused water clearness, in addition to a relative increase in the pH value and a remarkable decrease in its odor and electric conductivity (EC). In addition, it was observed that lead ions and bacterial content decreased. The study shows that the increasing magnetic field intensity to the level used in this study, accompanied by shacking, is supplemented with the findings of the experiment. It also suggests that the magnetic field plays a major role in finding successful solutions for a lot
A general theory of radio propagation by wave-guide modes is given, which simultaneously makes allowance for the gradualness of the lowest part of the ionosphere, the earths curvature and the earths magnetic field. The method involves solving differential equations satisfied by the matrix admittance or matrix reflexion coefficient variables. The mode condition, excitation factor, and polarization of the waves in a mode are derived by evaluating the residues of a series of poles of a contour integral. The earths curvature is allowed for by the method of the modified refractive index, thus avoiding the use of cumbersome spherical wave functions. This also permits the replacement of a point source by a line source with consequent further simplification of the mathematics. Formulae are given which have been used for computations described elsewhere (Budden & Martin 1962; Martin 1961). ...
Ministry of Human Resource Development (MHRD) under its National Mission on Education through Information and Communication Technology (NMEICT) has initiated the National Digital Library of India (NDL India) pilot project to develop a framework of virtual repository of learning resources with a single-window search facility. Filtered and federated searching is employed to facilitate focused searching so that learners can find out the right resource with least effort and in minimum time. NDL India is designed to hold content of any language and provides interface support for leading Indian languages. It is being arranged to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular form of access devices and differently-abled learners. It is being developed to help students to prepare for entrance and competitive examination, to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to ...
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Defending Tour de France champion Chris Froome will have his wrist X-rayed after crashing heavily during Tuesdays fourth stage, Team Sky manager Dave Brailsford said.
Irradiation Radiation is known to induce abnormalities in the nuclei of cells. Dicentric chromosomes were first detected in ... Tailed nuclei are signatures of radiation exposure in human tissue, microbiota, and aquatic invertebrates from the wake of ... Pseudodicentric chromosomes alone do not define these syndromes, because the contribution of other chromosomal abnormalities ... Chromosomal inversion Telomeres Cytogenetics Nuclear radiation Intellectual disorders Nussbaum, Robert; McInnes, Roderick; ...
Radiation-induced and chemotherapy-induced pulmonary injury. Curr Opin Oncol. 2001 Jul;13(4):242-8. Review. Camus P, Martin WJ ... An 82-year-old man with dyspnea and pulmonary abnormalities. N Engl J Med. 2003 Apr 17;348(16):1574-85. Meadors M, Floyd J, ... Pulmonary radiation injury. Chest. 1997 Apr;111(4):1061-76. Review. Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and ... Radiation (radiotherapy) is frequently used for the treatment of many cancer types, and can be highly effective. Unfortunately ...
Medication- or radiation-induced hypothyroidism. *Thyroid hormone resistance. *Euthyroid sick syndrome. *Congenital ... structural abnormalities, most commonly an enlargement of the thyroid gland; and 4) tumors which can be benign or cancerous. It ... and does not expose the individual to any radiation.[24] ... "Thyroid Function Abnormalities during Amiodarone Therapy for ...
... can be induced as a result of severe acute radiation poisoning with an absorbed dose of more than 30 Grays. Vitamin B12 ... Friedreich's ataxia has gait abnormality as the most commonly presented symptom. The word is from Greek α- [a negative prefix ... To obtain better results, possible coexisting motor deficits need to be addressed in addition to those induced by ataxia. For ... Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that includes gait abnormality. ...
... choanal atresia Radiation induced angiosarcoma of the breast Radiation induced meningioma Radiation leukemia Radiation related ... syndrome Radiophobia Radioulnar synostosis mental retardation hypotonia Radioulnar synostosis retinal pigment abnormalities ... cancer Radiation syndromes Radiation-induced brachial plexopathy Radiculomegaly of canine teeth congenital cataract Radio ... Retinohepatoendocrinologic syndrome Retinopathy anemia CNS anomalies Retinopathy aplastic anemia neurological abnormalities ...
"Chromosome Aberrations Induced by X-rays," which demonstrated that radiation could induce major genetic changes by affecting ... "the father of radiation cytology". Accipitridae Aneuploidy Chromosome abnormalities DbCRID Fusion gene Takifugu rubripes " ... Radiation Effects Research Foundation. Retrieved June 30, 2014. Li JY, Gaillard F, Moreau A, et al. (May 1999). "Detection of ... The paper is thought to mark the beginning of the field of radiation cytology, and led him to be called " ...
In 1938 Sax published a paper entitled "Chromosome Aberrations Induced by X-rays," which demonstrated that radiation could ... a chromosome abnormality. The paper is thought to mark the beginning of the field of radiation cytology, and led him to be ... noted for his research in cytogenetics and the effect of radiation on chromosomes. Sax was born in Spokane, Washington in 1892 ... called the "father of radiation cytology." Sax bred new varieties of ornamental trees and shrubs including Malus species (both ...
... including cognitive impairment attributable to within the womb radiation exposure.[54] As no radiation induced inherited ... No increase is expected in the incidence of congenital or developmental abnormalities, ... Now radiation in Japan is as bad as radiation level is raised to 7 for only the second time in history' Daily Mail 12 April ... Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ...
UV light can induce adjacent pyrimidine bases in a DNA strand to become covalently joined as a pyrimidine dimer. UV radiation, ... See also: Chromosome abnormality. By effect on structureEdit. Five types of chromosomal mutations. ... Ionizing radiation. Exposure to ionizing radiation, such as gamma radiation, can result in mutation, possibly resulting in ... Induced mutationEdit. Induced mutations are alterations in the gene after it has come in contact with mutagens and ...
... including cognitive impairment attributable to within the womb radiation exposure. As no radiation induced inherited effects/ ... No increase is expected in the incidence of congenital or developmental abnormalities, ... 12 April 2011 'Now radiation in Japan is as bad as radiation level is raised to 7 for only the second time in history' Daily ... indicated that the residents of the area who were evacuated were exposed to so little radiation that radiation induced health ...
Radiation tests in model organisms that determine the effects of high radiation on animals and plants are: Chromosomal ... These compounds mutate DNA strands and produce genetic damage, inducing newly lysis and subsequent cell death. Its action on ... Reproductive deficiencies: sterility, reduction in fecundity, and occurrence of developmental abnormalities or reduction in ... Lowy, R.J (2005). "Ionizing Radiation Inactivation of Medically Relevant Viruses". In Gazsó, L.G; Ponta, C.C. Radiation ...
Cellular mechanisms will repair some of this damage, but some repairs will be incorrect and some chromosome abnormalities will ... Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors ... Children and adolescents are twice as likely to develop radiation-induced leukemia as adults; radiation exposure before birth ... Ionizing radiation exposure of the population of the United States : recommendations of the National Council on Radiation ...
Cellular mechanisms will repair some of this damage, but some repairs will be incorrect and some chromosome abnormalities will ... Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors ... Children and adolescents are twice as likely to develop radiation-induced leukemia as adults; radiation exposure before birth ... Up to 10% of invasive cancers are related to radiation exposure, including both ionizing radiation and non-ionizing radiation. ...
If the abnormality involves a single step in the absorptive process, as in primary lactase deficiency, or if the disease ... Prolonged malnutrition may induce amenorrhea, infertility, and impotence. Edema and even ascites may reflect hypoproteinemia ... Radiation enteritis. *Systemic sclerosis and collagen vascular diseases. *Short bowel syndrome. Due to surgical structural ... ERCP will show pancreatic and biliary structural abnormalities.. Other investigationsEdit. *75SeHCAT test to diagnose bile acid ...
... they can induce high radiation doses which is a risk for patients with certain diseases. Methods based on MRI are not accurate ... The 2-D imaging has problems of anatomy overlapping with each other and don't disclose the abnormalities. The 3-D imaging can ... This method uses X-ray images for 3D Reconstruction and to develop 3D models with low dose radiations in weight bearing ... So, we discuss the following methods which can be performed while standing and require low radiation dose. Though these ...
Mammalian genes induced by radiation; activation of genes associated with growth control. Annual Rev. Genetics 26: 507-526, ... DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum. ... Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One 7: e42224, 2012. Mironova, N. ... In the radiation field he has received multiple awards including the Radiation Research Society Excellence in Mentoring Award ...
... the risks of more frequent mammograms include a small but significant increase in breast cancer induced by radiation.[110] ... A clinical or self breast exam involves feeling the breast for lumps or other abnormalities. Clinical breast exams are ... Radiation can also be given at the time of operation on the breast cancer. Radiation can reduce the risk of recurrence by 50-66 ... Surgery, radiation therapy, chemotherapy, hormonal therapy, targeted therapy[1]. Prognosis. Five-year survival rate ~85% (US, ...
"Severe and Unrecognized Dental Abnormalities After Drug-Induced Epidermal Necrolysis". Arch. Dermatol. 145 (11): 1332-1333. doi ... "Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study". ... Environmental causes involving exposure to PCBs (ex.dioxin),[18][19][20] radiation,[21][22][23] anticancer chemotherapeutic ... A relationship was also postulated between abnormalities of the brainstem and the presence of agenesis.[13] ...
A clotting abnormality and low platelet concentration in the blood should be immediately corrected if possible. Platelets ... and radiation proctitis; nonsteroidal anti-inflammatory drug (NSAID) use is a risk factor for diverticular bleeding and NSAID- ... induced colonic ulcer; and recent colonoscopy with polypectomy suggests postpolypectomy bleeding. Patients should be asked ... may be required to completely reverse clotting abnormalities, depending on the initial prothrombin time. Recombinant activated ...
2010). "Biodistribution and radiation dosimetry of [(11)C]choline: a comparison between rat and human data". European Journal ... 2010). "T2 relaxation time abnormalities in bipolar disorder and schizophrenia". Magnetic Resonance in Medicine 63 (1): 1-8. ... beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced ...
The severity and frequency of the congenital abnormalities seen increased with dose of radiation which depended on the ... One of the first environmentally induced congenital malformations in humans were recognized as a result of maternal irradiation ... There are a number of chemicals, biological agents (such as bacteria and viruses), and physical agents (such as radiation) used ... This term has widely replaced the early term for the study of primarily structural congenital abnormalities, teratology, to ...
Non-ionizing radiation[edit]. Whether or not non-ionizing radiation causes leukemia has been studied for several decades. The ... In addition to these genetic issues, people with chromosomal abnormalities or certain other genetic conditions have a greater ... Saven, A; Burian, C; Adusumalli, J; Koziol, J. A. (1999). "Filgrastim for cladribine-induced neutropenic fever in patients with ... Non-Ionizing Radiation, Part 1: Static and Extremely Low-Frequency (ELF) Electric and Magnetic Fields (IARC Monographs on the ...
... treatment induces autophagy,[5] which may suppress tumor growth. However, autophagy can also cause drug resistance.[6 ... A potentially fatal abnormality in the electrical activity of the heart *^ Swelling of the skin and mucous membranes ... Radiation recall dermatitis. *Stevens-Johnson syndrome[Note 34]. *Leucocytoclastic vasculitis. *Toxic epidermal necrolysis[Note ... "Chemotherapy-Induced Nausea and Vomiting Treatment & Management". Medscape Reference. WebMD. 3 July 2012. Retrieved 26 December ...
... residues by ATM and ATR threonine/serine kinases following DNA damage induced by chemical treatment or ionizing radiation. It ... Cornelia de Lange syndrome (CdLS) is a rare genetic disorder that presents with variable clinical abnormalities including ... response to radiation. • DNA repair. • sister chromatid cohesion. • response to DNA damage checkpoint signaling. • GO:0007126 ...
Medical use of ionizing radiation is a growing source of radiation-induced cancers. Ionizing radiation may be used to treat ... or cause other types of chromosome abnormalities. Major damage normally results in the cell dying, but smaller damage may leave ... Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors ... Children and adolescents are twice as likely to develop radiation-induced leukemia as adults; radiation exposure before birth ...
Structural abnormalities of the kidneys are identified with imaging tests. These may include Medical ultrasonography/ultrasound ... Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ...
History of Radiation Dermatitis. Earliest reports of radiation-induced skin changes date back to 1896, 9 months after ... Clinical presentation has been reported to include the development of a maculopapular erythematous abnormality generally within ... Radiation Dermatitis (radiodermatitis, radiation epidermitis, radiation skin toxicity, acute radiation skin reaction, late ... Radiation Dermatitis (radiodermatitis, radiation epidermitis, radiation skin toxicity, acute radiation skin reaction, late ...
Abnormalities, Drug-Induced. *Abnormalities, Multiple. *Abnormalities, Radiation-Induced. *Abnormalities, Severe Teratoid. * ... "Musculoskeletal Abnormalities" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Musculoskeletal Abnormalities" by people in this website by ... Below are the most recent publications written about "Musculoskeletal Abnormalities" by people in Profiles. ...
Abnormalities, Radiation-Induced - epidemiology Accidents, Radiation Autopsy Central Nervous System - abnormalities Croatia - ... Abnormalities, Radiation-Induced - epidemiology Accidents, Radiation Germany - epidemiology Humans Infant, Newborn Odds Ratio ... Abnormalities, Radiation-Induced - epidemiology Accidents, Radiation Cleft Lip - epidemiology Cleft Palate - epidemiology Cross ... Abnormalities, Radiation-Induced - epidemiology - genetics Accidents, Radiation Down Syndrome - epidemiology - genetics Humans ...
Conclusion: The risk of radiation induced myocardial perfusion abnormality in patients treated with CRT on the left hemi thorax ... A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of ... It is reasonable to minimize the volume of the heart being in the field of radiation employing didactic radiation planning ... Six months after radiation therapy, all patients underwent cardiac SPECT for the evaluation of myocardial perfusion. Results: A ...
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer. The safety ... Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer. ... The Modified ONS Criteria for Radiation-Induced Acute Skin Toxicity will be used for classification of EASRs related to the ... Patients are assessed for acute toxicity by research staff using the ONS Criteria for Radiation-Induced Acute Skin Toxicity at ...
Radiation Colitis. *Radiation Proctitis. *Radiation Tissue Damage. *Radiation-Induced Abnormalities. *Retinal Artery Occlusion ...
Conclusion: The radiation induced myocardial perfusion abnormalities in patients with left breast cancer could cause permanent ... 0.3±1.0; p=0.03). The indices of perfusion abnormality normalized in control subjects from baseline to follow up scans (p= 0.05 ... We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty ... They underwent myocardial perfusion scans (MPS) 3 years after the external beam radiation therapy at the bed of modified ...
Clinically significant laboratory tests abnormalities. *Conditions that limits patient compliance (dementia, psycho- ... Diagnosis of radiation-induced rectovaginal fistula established at least six months after radiation therapy ... Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula. The safety and ... Injection of autologous regenerative cells of adipose tissue for treatment of radiation induced rectovaginal fistulas ...
Cytostatic-Induced Central Nervous System Abnormalities Rudolf Korinthenberg. Pages 29-34 * Radiation Myelopathy ...
8. Aberrant subclavian artery abnormality. 9. Abnormalities, Radiation-Induced. 10. Abruzzo Erickson syndrome. More causes » , ...
4. Abnormalities, Radiation-Induced. 5. Absidia species poisoning. 6. Accutane -- Teratogenic Agent. 7. Acebutolol ...
4. Abnormalities, Radiation-Induced. 5. Absidia species poisoning. 6. Accutane -- Teratogenic Agent. 7. Acebutolol ...
4. Abnormalities, Radiation-Induced. 5. Absidia species poisoning. 6. Accutane -- Teratogenic Agent. 7. Acebutolol ...
4. Abnormalities, Radiation-Induced. 5. Absidia species poisoning. 6. Accutane -- Teratogenic Agent. 7. Acebutolol ...
4. Abnormalities, Radiation-Induced. 5. Absidia species poisoning. 6. Accutane -- Teratogenic Agent. 7. Acebutolol ...
8. Abnormalities, Radiation-Induced. 9. Absidia species poisoning. 10. Acanthamoeba. More causes » , Show All 2441 Causes , ...
1. Aberrant subclavian artery abnormality. 2. Abnormalities, Radiation-Induced. 3. Abruzzo Erickson syndrome. 4. Absent ...
8. Aberrant subclavian artery abnormality. 9. Abnormalities, Radiation-Induced. 10. Abruzzo Erickson syndrome. More causes » , ...
4. Abnormalities, Radiation-Induced. 5. Absidia species poisoning. 6. Accutane -- Teratogenic Agent. 7. Acebutolol ...
8. Aberrant subclavian artery abnormality. 9. Abnormalities, Radiation-Induced. 10. Abruzzo Erickson syndrome. More causes » , ...
1. Aberrant subclavian artery abnormality. 2. Abnormalities, Radiation-Induced. 3. Abruzzo Erickson syndrome. 4. Absent ...
8. Abnormalities, Radiation-Induced. 9. Absence of pulmonary artery. 10. Acarophobia. More causes » , Show All 3368 Causes , ...
8. Aberrant subclavian artery abnormality. 9. Abnormalities, Radiation-Induced. 10. Abruzzo Erickson syndrome. More causes » , ...
8. Aberrant subclavian artery abnormality. 9. Abnormalities, Radiation-Induced. 10. Abruzzo Erickson syndrome. More causes » , ...
6. Abnormalities, Radiation-Induced. 7. Absidia species poisoning. 8. Acanthamoeba. 9. Acanthamoeba infection. 10. Acanthamoeba ...
  • PLCD1-modified mice (F0) showed progressive hair loss after birth and the genotype of CRISPR/Cas9-induced mutations in exon 2 of PLCD1 locus, suggesting the sgRNA is effective to cause mutations that lead to hair growth defect. (biomedcentral.com)
  • Mutations in genes of the RAD52 group result in an increased sensitivity to ionizing radiation and defects in one or more types of recombination. (asm.org)
  • This includes damage caused by radiation, harmful chemicals, and random mutations that occur throughout the genome. (wikipedia.org)
  • Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. (wikipedia.org)
  • To test the effect of gene-gene and gene-smoking interactions on RT-induced skin reactions. (clinicaltrials.gov)
  • Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance. (jax.org)
  • The brief surfeit of MYC activity was accompanied by evidence of genomic instability, including karyotypic abnormalities, gene amplification, and hypersensitivity to DNA-damaging agents. (pnas.org)
  • Environmental factors, including toxins, radiation, and ultraviolet light, have cumulative effects, which are worsened by the loss of protective and restorative mechanisms due to alterations in gene expression and chemical processes within the eye. (wikipedia.org)
  • Matrix metalloproteinase 2 may be a candidate gene for bisphosphonate-associated osteonecrosis of the jaws, since it is the only gene known to be associated with both bone abnormalities and atrial fibrillation, another side effect of bisphosphonates. (wikipedia.org)
  • The most common abnormalities are t(9;22) and MLL gene rearrangement at 11q23. (wikipedia.org)
  • BCR/ABL induce cell adhesive and migratory abnormalities because the mutation will lead an abnormal response to chemokine SDF-1 MLL gene encode Histone-lysine N-methyltransferase (HRX), which is a histone methyltransferase. (wikipedia.org)
  • Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been reported. (wikipedia.org)
  • A silencer is a sequence-specific element that induces a negative effect on the transcription of its particular gene. (wikipedia.org)
  • This gene is a partner in a fusion gene with the BCR gene in the Philadelphia chromosome, a characteristic abnormality in chronic myelogenous leukemia (CML) and rarely in some other leukemia forms. (wikipedia.org)
  • For example, patients with a duplication of the Tbx2 gene region have presented with atrioventricular abnormalities including: interventricular septal defect, patent foramen ovale, aortic coarctation, tricuspid valve insufficiency, and mitral valve stenosis. (wikipedia.org)
  • Currently, there is convincing evidence in the scientific literature that the injection of intact autologous SCs into the zone of fibrosis surrounding the chronic radiation ulcer leads to the healing of a wound defect. (clinicaltrials.gov)
  • Pathogenetic mechanisms in radiation fibrosis. (springer.com)
  • Radiation-induced heart disease can manifest as pathology of the epicardial and endocardial coronary vessels resulting in coronary obstruction, semilunar and atrioventricular valves resulting in stenosis or regurgitation due to valvular fibrosis, myocardium with resultant cardiomyopathy, and conduction system and pericardium with pericardial constriction and inflammation. (acc.org)
  • Infections Certain medications, e.g. amiodarone, bleomycin (pingyangmycin), busulfan, methotrexate, apomorphine, and nitrofurantoin Radiation therapy to the chest Pulmonary fibrosis involves gradual exchange of normal lung parenchyma with fibrotic tissue. (wikipedia.org)
  • The indices of perfusion abnormality normalized in control subjects from baseline to follow up scans ( p = 0.05 for summed difference score and p =0.04 for summed stress score). (ac.ir)
  • Chemotherapy-induced liver injury may also bear on the morbidity and mortality after hepatic resection. (hindawi.com)
  • First described in the mid-1960s, radiation-induced heart disease is an under-recognized phenomenon associated with considerable morbidity and mortality. (acc.org)
  • Radiation injury occurs most readily in tissues and organs consisting of rapidly proliferating cells, as, for example, the skin, the lining of the gastrointestinal tract , and the bone marrow , where progenitor cells multiply continuously to replace the mature cells that are constantly being lost through normal aging. (britannica.com)
  • The tissues of the embryo, like others composed of rapidly proliferating cells, are extremely sensitive to ionizing radiation. (britannica.com)
  • When exposed to ionizing radiation, DR5-null tissues exhibit reduced amounts of apoptosis compared to wild-type thymus, spleen, Peyer's patches, and the white matter of the brain. (asm.org)
  • Although radiation doses to a fetus tend to be lower than the dose to the mother, due to protection from the uterus and surrounding tissues, the human embryo and fetus are sensitive to ionizing radiation at doses greater than 0.1 gray (Gy). (cdc.gov)
  • To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams are aimed from several angles of exposure to intersect at the tumor, providing a much larger absorbed dose there than in the surrounding, healthy tissue. (wikipedia.org)
  • Early miscarriages can be due to a developmental abnormality of the placenta or other embryonic tissues. (wikipedia.org)
  • There is persuasive evidence from the epidemiological studies of a large cohort of female nuclear workers that ionising radiation exposure is associated with significant low dose region dose-dependent increases in rates of dementia. (scirp.org)
  • Sources of ionizing radiation may be natural (e.g., radioactive substances such as the element radium or the radioisotopes potassium-40 and carbon-14) or man-made (X-ray machines, nuclear reactors, particle accelerators, nuclear weapons, etc. (britannica.com)
  • Overview of nuclear radiation and its effects on the human body. (britannica.com)
  • Tailed nuclei are signatures of radiation exposure in human tissue, microbiota, and aquatic invertebrates from the wake of recent nuclear disasters. (wikipedia.org)
  • A link to BRCA1 is also supported by radiation-induced phosphorylation of serine-988 by CHK2, leading to the dispersal of BRCA1 nuclear dots ( 13 ). (pubmedcentralcanada.ca)
  • Of course, it was normal for people to fear radiation during the Cold War and now, as our fossil fuel reserves are close to depletion, nuclear energy is something desperately needed to compensate. (topdocumentaryfilms.com)
  • How much of this documentary was actually about dispelling the exaggerated fear of radiation and how much was about promoting nuclear power is for you to decide. (topdocumentaryfilms.com)
  • radiation is also present in the environment as a result of nuclear weapons testing and as a consequence of discharges from nuclear sites and from nuclear accidents. (encyclopedia.com)
  • Typical contributors to such risk include natural background radiation, medical procedures, occupational exposures, nuclear accidents, and many others. (wikipedia.org)
  • In accordance with ICRP recommendations, most regulators permit nuclear energy workers to receive up to 20 times more radiation dose than is permitted for the general public. (wikipedia.org)
  • Some occupations are exposed to radiation without being classed as nuclear energy workers. (wikipedia.org)
  • These radioactive particles are by-products generated as a result of activities related to nuclear energy and constitute a pollution and a radiotoxicity problem (with serious health and ecological consequences) due to its unstable nature of ionizing radiation emissions. (wikipedia.org)
  • It was the largest nuclear disaster since the Chernobyl disaster of 1986, and the radiation released exceeded official safety guidelines. (wikipedia.org)
  • It can be inferred that nuclear abnormalities are a result of various molecular mechanisms. (wikipedia.org)
  • THz-wave radar that can sense radioactive plumes from nuclear plants have detected plumes several kilometers away based on radiation-induced ionization effects in air. (wikipedia.org)
  • The radiation effects from the Fukushima Daiichi nuclear disaster are the observed and predicted effects resulting from the release of radioactive isotopes from the Fukushima Daiichi Nuclear Power Plant after the 2011 Tōhoku earthquake and tsunami. (wikipedia.org)
  • However, a December 2012 UNSCEAR statement to the Fukushima Ministerial Conference on Nuclear Safety advised that "because of the great uncertainties in risk estimates at very low doses, UNSCEAR does not recommend multiplying very low doses by large numbers of individuals to estimate numbers of radiation-induced health effects within a population exposed to incremental doses at levels equivalent to or lower than natural background levels. (wikipedia.org)
  • History of agranulocytosis or severe (grade 3) drug-induced neutropenia or documented abnormalities in granulocyte number or function. (clinicaltrials.gov)
  • MC4R may also have clinical utility as a biomarker for predicting individual susceptibility to drug-induced adverse effects causing weight gain and related metabolic abnormalities. (wikipedia.org)
  • Flecainide has a very high affinity for lung tissue and is associated with drug-induced interstitial lung disease. (wikipedia.org)
  • Effect of Low-Dose Irradiation upon T Cell Subsets Involved in the Response of Primed A/J Mice to SaI Cells," INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 53, No.1: 103-118. (ratical.org)
  • Histological abnormalities of the reduced number of hair follicles, irregularly arranged and curved hair follicles, epidermal hyperplasia and disturbed differentiation of epidermis were observed in the PLCD1-deficient mice. (biomedcentral.com)
  • MmRAD52 null mutant mice showed no abnormalities in viability, fertility, and the immune system. (asm.org)
  • The transgenic mice thus generated are viable, demonstrating that there are c-fos dependent and independent pathways of cell proliferation, but display a range of tissue-specific developmental defects, including osteoporosis, delayed gametogenesis, lymphopenia and behavioral abnormalities. (wikipedia.org)
  • Induced genetic abnormality assays including microchromosome reverse mutation and E. coli mutagenicity assays were completed using mice. (wikipedia.org)
  • Twenty seven tests were carried out on mutant mice and four significant abnormalities were observed. (wikipedia.org)
  • The remaining tests were carried out on heterozygous mutant adult mice and two significant abnormalities were observed. (wikipedia.org)
  • ABSTRACT: The effect of ionising radiation exposure on dementia is approached by applying the causation models of John Stuart Mill and of Sir Austin Bradford Hill to mechanism and epidemiological evidence. (scirp.org)
  • In the intestinal form of radiation sickness, the main phase is characterized by abdominal pain, fever , and diarrhea , which lead within several days to dehydration, prostration, and a fatal shocklike state. (britannica.com)
  • Recently, bile acids were shown to be able to induce intestinal differentiation, in gastroesophageal junction cells, through inhibition of the epidermal growth factor receptor (EGFR) and the protein kinase enzyme Akt. (wikipedia.org)
  • Secondary lymphedema is the lymphadenectomy and lymphatic injury following surgery, radiation, chemotherapy, and/or trauma which healing or regeneration of damaged lymphatics may occur with variable success. (wikipedia.org)
  • Radiation phobia syndrome which developed in many persons, is the only sanitary effect noticed up to now. (arctichealth.org)
  • She is a pre-eminent expert in the use of hematopoietic stem cell transplantation for treating radiation injuries and blood disease, especially leukemia, aplastic anemia and myelodysplastic syndrome. (wikipedia.org)
  • A painful, swollen and blue arm, particularly when occurring after strenuous physical activity, could be the first sign of a subclavian vein compression related with an unknown TOS and complicated by thrombosis (blood clots), the so-called Paget-Schroetter syndrome or effort-induced thrombosis. (wikipedia.org)
  • Nausea, vomiting, diarrhoea, loss of appetite and uneasiness are initially noticed and depending on the radiation dose, the severity of symptoms may increase. (org.in)
  • This is complemented by gastro-coronary reflexes whereby the coronary arteries constrict with "functional cardiovascular symptoms" similar to chest-pain on the left side and radiation to the left shoulder, dyspnea, sweating, up to angina pectoris -like attacks with extrasystoles, drop of blood pressure, and tachycardia (high heart beat) or sinus bradycardia (heart beat below 60). (wikipedia.org)
  • If you have an ultrasound or sleep study, ensure that you know how to reproduce the symptoms, as it is difficult to detect any abnormalities when symptoms have subsided. (wikipedia.org)