The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.
Dose-Response Relationship, Radiation
The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.
Radiation Injuries, Experimental
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Combined Modality Therapy
Acute Radiation Syndrome
A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
Radioactive Hazard Release
Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.
Radiation Hybrid Mapping
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
Magnetic Resonance Imaging
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Tomography, X-Ray Computed
Linear Energy Transfer
Radiotherapy Planning, Computer-Assisted
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Relative Biological Effectiveness
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
Chernobyl Nuclear Accident
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.
In Situ Hybridization, Fluorescence
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
Sensitivity and Specificity
Carcinoma, Squamous Cell
Neoplasm Recurrence, Local
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
Devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Disease Models, Animal
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Image Processing, Computer-Assisted
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tumor Suppressor Protein p53
Organs at Risk
Antineoplastic Combined Chemotherapy Protocols
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Ataxia Telangiectasia Mutated Proteins
A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Sex Chromosome Aberrations
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Tumor Cells, Cultured
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Analysis of Variance
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Radiation Leukemia Virus
Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay.
Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe. EUROCAT Working Group. (1/64)BACKGROUND: Surveillance data from population-based congenital anomaly registers in 16 regions of Europe (mainly Western Europe) were analysed to assess the impact of the Chernobyl accident on the prevalence of selected congenital anomalies. METHODS: Three cohorts of pregnancies were defined: those exposed during the first month following Chernobyl (External Exposure Cohort), the first year (Total Exposure Cohort) and the two subsequent years (Control Cohort). Expected numbers of congenital anomalies in these cohorts were calculated from 1980-1985 baseline rates. Registries were grouped into three exposure categories according to first-year exposure estimates. RESULTS: There was no overall or dose-related increase in prevalence in the two exposed cohorts for Down's Syndrome, neural tube defects, other central nervous system defects or eye defects. There was a statistically significant overall 22% (95% CI: 13-31%) excess of Down's Syndrome in the Control Cohort, with no dose-response relationship. CONCLUSIONS: Chernobyl had no detectable impact on the prevalence of congenital anomalies in Western Europe, suggesting that in retrospect the widespread fear in the population about the possible effects of exposure on the unborn fetus was not justified. An increasing prevalence of Down's Syndrome in the 1980s, probably unrelated to Chernobyl, merits further investigation. (+info)
Reduced inhibition in an animal model of cortical dysplasia. (2/64)Cortical dysplasia has a strong association with epilepsy in humans, but the underlying mechanisms for this are poorly understood. In utero irradiation of rats produces diffuse cortical dysplasia and neuronal heterotopia in the neocortex and hippocampus. Using in vitro neocortical slices, whole-cell patch-clamp recordings were obtained from pyramidal neurons in dysplastic cortex and control neocortex. Spontaneous IPSCs were reduced in amplitude (35%) and frequency (70%) in pyramidal cells from dysplastic cortex. Miniature IPSCs were reduced in frequency (66%) in dysplastic cortex. Two additional measures of cortical inhibition, monosynaptic evoked IPSCs and paired pulse depression of evoked EPSCs, were also impaired in dysplastic cortex. Spontaneous EPSCs were increased in amplitude (42%) and frequency (77%) in dysplastic cortex, but miniature EPSCs were not different between the two groups. These data demonstrate significant physiological impairment in inhibitory synaptic transmission in experimental cortical dysplasia. This supports previous immunohistochemical findings in this model and observations in humans of a reduction in the density of inhibitory interneurons in dysplastic cortex. (+info)
Maintaining a proper perspective of risk associated with radiation exposure. (3/64)OBJECTIVES: The objectives of this article are to provide the reader with (a) a brief discussion of actual, perceived, and acceptable risks associated with radiation exposure; (b) a basic review of radiation protection units and a discussion as to how these units are used to estimate risk associated with occupational radiation exposure; (c) a summary of radiation doses required for specific human biologic responses and a comparison of relative doses encountered in a variety of clinical situations; and (d) a practical approach to discussing relative risks associated with medical radiation exposures when patients inquire. (+info)
Dependence of malformation upon gestational age and exposed dose of gamma radiation. (4/64)In order to evaluate the importance of gestational age and the dose-incidence relationship by gamma radiation, pregnant ICR mice at gestational days from 2.5 to 15.5 days post-coitus (p.c.) were exposed to a single dose of 2.0 Gy and also at day 11.5 after conception, which was the most sensitive stage for the induction of major congenital malformations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, changes in head size and other morphological abnormalities. The only demonstrable effect of irradiation during the pre-implantation period was an increase in prenatal mortality. Resorptions were maximal on exposure at day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. A small head, growth retardation, a cleft palate, dilatation of the cerebral ventricle, a renal pelvis, and abnormalities of the extremities and tail after exposure were prominent during the organogenesis period, especially on day 11.5 of gestation. As for the dose-incidence relationship, the incidence of a small head, growth-retarded fetuses, a cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose as the radiation dose increased. The result indicated that the late period of organogenesis in the development of the brain, skull and extremities of a mouse was a particularly sensitive phase. The threshold doses of radiation that induced a cleft palate and dilatation of the cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively. (+info)
The combined effects of MRI and X-rays on ICR mouse embryos during organogenesis. (5/64)The combined effects of X-rays and magnetic resonance imaging (MRI) on mouse embryos at an early stage of organogenesis were investigated. Pregnant ICR mice were irradiated on day 8 of gestation with X-rays at a dose of 1 Gy and/or MRI at 0.5 T for 1 hour. The mortality rates of the embryos or fetuses, the incidence of external malformations, the fetal body weight and the sex ratio were observed at day 18 of gestation. A significant increase in embryonic mortality was observed after exposure to either 1 Gy of X-radiation or 0.5 T MRI. However, the combined X-rays and MRI did not show a statistically significant increase in embryonic mortality compared with the control. External malformations, such as exencephaly, a cleft palate and anophthalmia, were observed in mice irradiated with X-rays and/or MRI. The incidence of each malformation in all treated groups increased with statistical significance compared with the control mice. The incidence in mice irradiated with both X-rays and MRI was lower than in mice irradiated with only X-rays. The combined effects of the combination of radiation and MRI on the external malformations might be antagonistic. There were no statistically significant differences in fetal death, fetal body weight and sex ratio among all experimental groups. (+info)
Effects of a 4.7 T static magnetic field on fetal development in ICR mice. (6/64)In order to determine the effects of a 4.7 T static magnetic field (SMF) on fetal development in mice, we evaluated fetal teratogenesis and endochondral ossification following exposure in utero. Pregnant ICR mice were exposed to a 4.7 T SMF from day 7.5 to 9.5 of gestation in a whole-body dose, and sacrificed on day 18.5 of gestation. We examined the incidence of prenatal death, external malformations and fetal skeletal malformations. There were no significant differences observed in the incidence of prenatal death and/or malformations between SMF-exposed mice and control mice. Further, we evaluated the immunoreactivity for the vascular endothelial growth factor (VEGF), which is implicated in angiogenesis and osteogenesis, in the sternum of fetal mice following magnetic exposure. Our studies also indicated that on day 16.5 of gestation following SMF exposure, the immunoreactivity for VEGF was increased compared to unexposed controls. However, it was decreased in the exposed group compared to the control group on day 18.5 of gestation. DNA and proteoglycan (PG) synthesis were also measured in rabbit costal growth plate chondrocytes in vitro. No significant differences were observed in DNA synthesis between the SMF exposed chondrocytes and the control chondrocytes; however, PG synthesis in SMF exposed chondrocytes increased compared to the controls. Based on these results, we suggest that while SMF exposure promoted the endochondral ossification of chondrocytes, it did not induce any harmful effects on fetal development in ICR mice. (+info)
Model prediction of treatment planning for dose-fractionated radioimmunotherapy. (7/64)BACKGROUND: Clinical trials of radioimmunotherapy (RIT) often use dose fractionation to reduce marrow toxicity. The dosing scheme can be optimized if marrow and tumor cell kinetics following radiation exposure are known. METHODS: A mathematic model of tumor clonogenic cell kinetics was combined with a previously reported marrow cell kinetics model that included marrow stromal cells, progenitor cells, megakaryocytes, and platelets. Reported values for murine tumor and marrow cellular turnover rates and radiosensitivity were used in the model calculation. RESULTS: Given a tolerated level of thrombocytopenia, there is a fractionation scheme in which total radioactive dose administration can be maximized. Isoeffect doses that had different numbers of fractions and total radioactivity, but induced identical platelet nadirs of 20%, were determined. Assuming identical tumor uptake for all dose fractions, six tumor types were examined: early-responding tumors, late-responding tumors, and tumors that lacked a late-responding effect, with either constant or accelerated doubling time. For most tumor types, better tumor control (tumor growth delay and nadir of survival fraction) was predicted for a dosing scheme in which total radioactive dose was maximized. For late-responding tumors with accelerated doubling time, tumor growth delay increased, but the nadir of survival fraction became shallower as the number of fractions increased. CONCLUSIONS: A mathematic model has been developed that allows prediction of the nadir and duration of thrombocytopenia as well as tumor clonogenic cell response to various RIT doses and fractionation schemes. Given a maximum tolerated level of thrombocytopenia, the model can be used to determine a dosing scheme for optimal tumor response. (+info)
Elevated minisatellite mutation rate in the post-chernobyl families from ukraine. (8/64)Germline mutation at eight human minisatellite loci has been studied among families from rural areas of the Kiev and Zhitomir regions of Ukraine, which were heavily contaminated by radionuclides after the Chernobyl accident. The control and exposed groups were composed of families containing children conceived before and after the Chernobyl accident, respectively. The groups were matched by ethnicity, maternal age, parental occupation, and smoking habits, and they differed only slightly by paternal age. A statistically significant 1.6-fold increase in mutation rate was found in the germline of exposed fathers, whereas the maternal germline mutation rate in the exposed families was not elevated. These data, together with the results of our previous analysis of the exposed families from Belarus, suggest that the elevated minisatellite mutation rate can be attributed to post-Chernobyl radioactive exposure. The mechanisms of mutation induction at human minisatellite loci are discussed. (+info)
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Pregnant ICR mice (Nihon-SLC) were used for in utero electroporation. Noon of the day at which the vaginal plug was detected was designated as embryonic day 0.5 (E0.5) and E19.5 was defined as P0.5. In utero electroporation was conducted on E13.5-13.75 embryos as described previously (Hatanaka et al., 2004) with minor modifications. Briefly, a 1-1.5 μl plasmid solution was injected into the lateral ventricle and 30 V or 40 V electric pulses of 50 ms duration were delivered at 200 ms intervals. Plasmids were prepared with the NucleoBond Midi Kit (Macherey-Nagel), suspended in PBS (0.1 m, pH 7.4) and electroporated at the following final concentrations: 1.0 μg/μl pCAG-EGFP-IRES-mito-mCherry for analysis of the mitochondrial distribution during the development of dendritic arbors; 3.0 μg/μl pCAG-Mfn1 and 1.0 μg/μl pCAG-EGFP-IRES-mito-mCherry for analysis of the mitochondrial distribution and dendritic morphology in Mfn1-overexpressing neurons; 3.0 μg/μl pCAG-Mfn1 and 1.0 μg/μl ...
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An iconic hotel in the heart of midtown Manhattan is buzzing with thousands of tiny new visitors. But watch out: Theyll sting if you get too close. Honeybees have taken up residence at the Waldorf-A
radiographer resume australia
Conduct liquid penetrant tests to locate surface cracks by coating objects with fluorescent dyes, cleaning excess. With more than 25 years experience, Successful Resumes is a leader in professional resume and CV writing. Learn more about the role including real reviews and ratings from current Radiographers, common tasks and duties, how much Radiographers earn in your state, the skills current Employers are looking for and common education and career pathways. Provide staffing solutions to cardiac cath labs, Electrophysiology labs, Interventional Radiology labs, and GI labs. Australian Institute of Radiography (AIR) Accreditation If you are a radiographer looking to be an accredited radiographer then the Australian Institute of Radiography (AIR). Properly documents all required information, Maintains and correctly develops film by means of CR system. They also need to ensure patient safety and avoid unnecessary X-ray exposure. Its actually very simple. Radiographers use imaging equipment to ...
NFL | Zac Stacy heads for X-rays on left ankle - Rotoworld.com
Zac Stacy heads for X-rays on left ankle If you play fantasy sports, get breaking news and immerse yourself in the ultimate fan experience.
Intersecting space and volume: the m+r residence at Altedo
Altedo di Malalbergo on the route between Bologna and Ferrara is where the practice of Diverserighe (architects Simone Gheduzzi, Nicola Rimondi and Gabriele Sor
X-rays on projection CRT | Forum for Electronics
Hi I had given an old CRT-based rear-projection TV, which I dissasembled. But before doing so I opened it and operated it a few times (total 30 minutes or...
dental xrays | Ask MetaFilter
FWIW, my dentist knows that I and my family do not want excessive x-rays. Before taking any x-rays, we are asked whether it is ok and I have never felt in any way forced to submit to x-rays. The dentist I went to before my current one was very agitated when I refused x-rays on a six month basis for my 3 year old and made me sign a release absolving the practice of any responsibility for missed problems. I found a new dentist after that happened ...
August 2018 - Clear Lake Dental Care
You may have had to have an X-ray on your arm when you were a kid to see if it was broken or not, but X-rays are also used in dentistry as a way for us to check on your overall oral health- specifically the bones in your mouth. And although traditional X-rays are still ...
Low grade fever for one month | Ask The Doctor
What is the possible cause for afternoon (2-7:00 pm) slight fever, around 99.2-99.9? It has been last for more than one month after contracted a flu and I had taken 2 doses of antibiotic each for 5 days. Had x-ray on lung showing a 3mm pos
RAD 205 - Radiographic Pathology | Technical College of the LowCountry
This course provides a survey of disease processes significant to the radiographer, including etiology, diagnosis, prognosis, and treatment.. ...
Evaluation of radiographers mammography screen-reading accuracy in Australia (Journal Article) | SciTech Connect
This study aimed to evaluate the accuracy of radiographers screen-reading mammograms. Currently, radiologist workforce shortages may be compromising the BreastScreen Australia screening program goal to detect early breast cancer. The solution to a similar problem in the United Kingdom has successfully encouraged radiographers to take on the role as one of two screen-readers. Prior to consideration of this strategy in Australia, educational and experiential differences between radiographers in the United Kingdom and Australia emphasise the need for an investigation of Australian radiographers screen-reading accuracy. Ten radiographers employed by the Westmead Breast Cancer Institute with a range of radiographic (median = 28 years), mammographic (median = 13 years) and BreastScreen (median = 8 years) experience were recruited to blindly and independently screen-read an image test set of 500 mammograms, without formal training. The radiographers indicated the presence of an abnormality using ...
North West London Diagnostic Radiographer Education Day | Healthier North-West London (NHS)
The NHS in NW London took a day out to support and encourage radiographers to reach their career goals and aspirations, at our Diagnostic Radiographer Education Day on Saturday 28 January. Radiographers and radiography students joined inspirational speakers from across NW London to discuss careers in radiography and emerging technology. There were also opportunities to network with the leadership teams from trust imaging departments.
KAKEN - Research Projects | Influences of extremely low-frequency alternate-current high magnetic fields on gene replication,...
Principal Investigator：YAMAMOTO Hiroshi, Project Period (FY)：1998 - 1999, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：電磁場環境
Mapping starspots and magnetic fields on cool stars
Until about a decade ago, the substructures seen in the Balmer-line profiles of active stars were generally regarded as too complex for quantitative study. Since then, however, detector technology has improved to the point where we can monitor the evolution of these structures with temporal sampling rates high enough to allow us to see coherent patterns in the data. Although some of the patterns that have emerged from such studies are consistent with stochastic flare activity, a large part of the complex substructure seen in the Balmer lines appears to be caused by mass motions of clumps of Balmer emitting and absorbing material. As these clumps are embedded in the much hotter ambient medium of the stellar corona, they are usually dubbed ``prominences by analogy to solar prominences. Some of the mass motions seen in association with stellar flares are transient, and appear to resemble the prominence eruptions seen on the Sun in connection with coronal mass ejections and two-ribbon flares. ...
ISRCTN - ISRCTN21818068: Immediate reporting of chest X-rays referred from general practice by reporting radiographers
When compared to other common cancers, lung cancer patients are less likely to survive their cancer. This is often due to a delay in the recognition of the condition and performance of the chest X-ray (CXR). Delayed diagnosis reduces treatment choices because the cancer may have spread further and the person may have become too ill for treatment to be given safely. It is hoped that by diagnosing lung cancer sooner this will help improve survival, help with patient satisfaction and potentially extend the range of treatment options, which are more limited in delayed diagnosis. CXRs are often used when lung cancer is suspected, but there can be long delays for the results to be available to the patient and the GP. Radiographers traditionally take the X-ray, but they are reported by a radiologist, a medical specialist. Recent studies show that radiographers who have completed further training can report CXRs with similar accuracy to radiologists. This project will help to reduce delays in diagnosis ...
Experimental Studies on Congenital Malformations (1959), by James G....
Experimental Studies on Congenital Malformations (1959), by James G. Wilson The article Experimental Studies on Congenital Malformations was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson, studied embryos and birth defects
Q07.9 ICD-10-CM Code - Congenital malformation of nervous system,
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system - Q07.9
Q00-Q07 ICD-10 List Covers Diagnosis Codes | Congenital malformations of the nervous system
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system
Cephalotripsy - Metamorphic Congenital Malformation lyrics | LyricsMode.com
Metamorphic Congenital Malformation lyrics by Cephalotripsy: Scourging paths of the impermissible / Descending upon dwellings of those
Palatial living: luxury residences where proximity to the royal palaces is the USP
When Niccolo Barattieri di San Pietro, the CEO of property developer Northacre, was recently showing a prospective buyer from the Middle East around one of the remaining residences at No.
Gunmen Archives - The Nation Nigeria
Unknown gunmen have abducted a 14-year-old girl in Kankia local government area of Katsina State. Father of the victim, Alhaji Salisu Mai-Tiles, said the gunmen invaded his residence at Sabuwar-Abuja quarters in Kankia at 1:30 a.m. on Thursday. He said that three well- armed persons broke into his residence and demanded for money, while the remaining gang members stayed outside. They asked me to give them money, which I did; whatever they asked we never objected to their demand to… Read more ...
Free Horse: Grey TB exracer | Bold To Say, aka Smokey | TheHorse.com
Quiet exracer rescued 10/07, bone thin and foundered. Rehabbed and looking for a new home. Has been trailridden by children, knows leg cues and direct rein. Vet recommends flatwork and trails only. Loves attention, stands quietly for ferrier, nice manners. Rescue photos, x-rays on site. This guy deserves a break.. ...
My Cultural Landscape: March 2011
Both Becketts and Enos plays are filled with a wicked sense of humor.What separates both authors from their contemporaries, however, is their profound depth. Their work burrows down into the most intimate vulnerabilities of the human soul. With both writers, at one moment I am laughing myself to the floor and the next I feel as though I am having an epiphany. What makes Eno a Samuel Beckett for the Jon Stewart generation is that he is so much of our time. Just as Beckett exploited the forms of slapstick comedy, vaudeville, and silent movies, Eno puts his profound ideas in the forms of stand-up comedy and the 24-hour news cycle. The fact that he is able to tackle such weighty themes in these forms is exactly what makes his work so surprising and catches us off guard. He is one of the most exciting playwrights alive today and having him in residence at Cutting Ball this March is an extraordinary treat ...
A Further Investigation of the Effects of Extremely Low Frequency Magnetic Fields on Alkaline Phosphatase and...
Using a custom build spectrophotometer equipped with Helmholtz coils and designed to study the effects of magnetic fields on enzyme reactions in real-time we have investigated the influence of fields, from 100 ?T to 10 mT and at a variety of field frequencies, on the membrane bound enzymes alkaline phosphatase and acetylcholinesterase. We have also employed other methods to apply a magnetic field, e.g. Biostim. In contrast to earlier reports we have been unable to detect any field effects on these enzymes under any field/frequency regime. We discuss possible reasons for the discrepancy between this and earlier work and note the particularly complex influence of small temperature changes that may confound analysis.. ...
Congenital malformations, deformations and chromosomal abnormalities: Congenital malformations of the nervous system;...
Q00-Q99 - Congenital malformations of the circulatory system; Congenital malformations of the respiratory system; Cleft lip and cleft palate; Other congenital malformations of the digestive system; Congenital malformations of genital organs; Congenital malformations of the urinary system; Congenital malformations and deformations of the musculoskeletal system; Other congenital malformations; Chromosomal abnormalities, not elsewhere classified: Diseases and Medical Conditions (ICD-10) from Drugs-about.com
Effects of energetic silicon ions, u.v. Radiation and x-rays on neopla by T C. Yang, J Howard et al.
Yang, T C.; Howard, J; Craise, L; and Tobias, C A., Effects of energetic silicon ions, u.v. Radiation and x-rays on neoplastic cell transformation and mutation. Abstr. (1982). Subject Strain Bibliography 1982. 4006 ...
MRI Radiographer job in Doha: Jobs & Recruitment - Cavendish Professionals
MRI Radiographer Job: We are working in partnership with the Sidra Medicine. Our client is an ultramodern, all-digital academic medical centre specialising in the provision of care | Cavendish Recruitment
Radiographer Industrial Salary in Arkansas, United States - ERI | SalaryExpert
The average radiographer industrial salary in Arkansas, United States is $45,025 or an equivalent hourly rate of $22. Salary estimates based on salary survey data collected directly from employers and anonymous employees in Arkansas, United States.
Download Computed Tomography For Radiographers
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LiveDNA: Publications of Randa M. Mostafa
21: Mostafa, R.M., A.L.H. El Hefnawi, K.M. Moustafa, F.M. Ali, Y.M. Moustafa, S. Kamal and M.H. El Hefnawi, 2007. Effect of 50 Hz, 10 mTesla magnetic field on sex hormones level in male rats. J. Med. Sci. Res., 1: 31-36. ...
X-Ray Art | The Perpetual Preschool
When our class studies the letter X we make hand x-rays on black construction paper by tracing around each students hand with white chalk, then painting the
bit by bit putting it together: December 2013
We all stood in perplexed silence for a moment. I looked at the chest X-ray on the box in front of me and systematically began to analyze it. Based on the size of the chest it looked like an adult, probably male since no breast shadows were evident. Good quality film, no rotation. Heart normal size. Lungs… Something about the lungs. They were clear for the most part: Black fields indicating that the X-rays were going clear through the mostly-air of the lungs to expose the film behind, blocked at regular intervals by the gentle white arcs of ribs bordering and encircling the chest. But in the blackness where there should be nothing - more white, something, some things, in the lungs blocking the X-rays, things that looked like huge cotton balls. Fluffy infiltrates is the term radiologists use for lesions such as these. I thought I could rattle off a few things that did this, but it would help to know more about this patient. I knew my place so the resident was the one who asked the question ...
A Yeadon pharmacy is getting behind next Wednesdays national No Smoking Day (10 March) by taking up temporary residence at two local health centres in a bid to help members of the community stop smoking. Following the success of last years event at Yeadon Health Centre, staff from The Co-operative Pharmacy in High Street will […]. ...
Obituaries | Daily News
BOTEJUE - LESLY. (Retired Sri Lanka Tourist Board). Loving husband of Yvonne (retired Peoples Bank), brother of Pearl, late Preeni and Anton, brother-in-law of Peter, Geetha, Shiranthi, Padmini and Chandrakumari. Remains lie at No. 17, Mendis Avenue, Idama, Moratuwa. Cortege leaves residence at 4.00 p.m. on Friday 15th December 2017 for burial at the General Cemetery (Anglican Section), Holy Emmanuel Church, Idama, Moratuwa at 4.30 p.m.155960
Men arrested for possession of methamphetamine (ICE)
23 May, 2017. A search warrant executed by Police on Wednesday 17 May 2017 at a residence at Kolomotua, resulted in the arrest of a 45 year old...
Synapse - Art Science Collaborations
Im currently the Artist in Residence at The Arts & Genomics Center in Leiden, the Netherlands. Im working on a project to create a dynamic display made of fluorescent bacteria.. biodisplay.tyrell.hu/ ...
Dream | HuffPost Canada
Every July, around 10 Canadian universities scattered across the country play host to 500 students from all provinces/territories and even internationally. Although the program is for open-minded high school students who are not afraid to delve into any subject and become challenged or inspired in ways they never thought possible in one month, I hope to break the stereotype that this is nerd camp. My program consisted of 56 total Shads and we lived in residence at the university ...
1. Rationale | Society of Radiographers
1.1 This guidance and advice document overviews safety issues in Magnetic Resonance Imaging (MRI) and, while not claiming to be all-inclusive, it provides direction to where appropriate information can be found. All members of the workforce who are working or intending to work in the field are recommended to read the literature listed in this document to gain a more in
Two-horned uterus is a congenital malformation in which the uterus has an irregular shape that is divided into two so-called horns, two separate cavities that
Irradiation Radiation is known to induce abnormalities in the nuclei of cells. Dicentric chromosomes were first detected in ... Tailed nuclei are signatures of radiation exposure in human tissue, microbiota, and aquatic invertebrates from the wake of ... Anbumani, S.; Mohankumar, Mary N. (2015-08-12). "Nucleoplasmic bridges and tailed nuclei are signatures of radiation exposure ... Pseudodicentric chromosomes alone do not define these syndromes, because the contribution of other chromosomal abnormalities ...
Medication- or radiation-induced hypothyroidism. *Thyroid hormone resistance. *Euthyroid sick syndrome. *Congenital ... structural abnormalities, most commonly an enlargement of the thyroid gland; and 4) tumors which can be benign or cancerous. It ... and does not expose the individual to any radiation. ... "Thyroid Function Abnormalities during Amiodarone Therapy for ...
Radiation poisoning. Ataxia can be induced as a result of severe acute radiation poisoning with an absorbed dose of more ... Friedreich's ataxia has gait abnormality as the most commonly presented symptom. The word is from Greek α- [a negative ... Peculiar writing abnormalities (large, unequal letters, irregular underlining). *A peculiar pattern of dysarthria (slurred ... To obtain better results, possible coexisting motor deficits need to be addressed in addition to those induced by ataxia. For ...
Radiation-induced and chemotherapy-induced pulmonary injury. Curr Opin Oncol. 2001 Jul;13(4):242-8. Review. Camus P, Martin WJ ... An 82-year-old man with dyspnea and pulmonary abnormalities. N Engl J Med. 2003 Apr 17;348(16):1574-85. Meadors M, Floyd J, ... Pulmonary radiation injury. Chest. 1997 Apr;111(4):1061-76. Review. Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and ... Radiation (radiotherapy) is frequently used for the treatment of many cancer types, and can be highly effective. Unfortunately ...
"Chromosome Aberrations Induced by X-rays", which demonstrated that radiation could induce major genetic changes by affecting ... "the father of radiation cytology". Accipitridae Aneuploidy Chromosome abnormalities DbCRID Fusion gene Pseudodiploid Takifugu ... Radiation Effects Research Foundation. Retrieved June 30, 2014. Li JY, Gaillard F, Moreau A, et al. (May 1999). "Detection of ... The paper is thought to mark the beginning of the field of radiation cytology, and led him to be called " ...
List of diseases (R)
... choanal atresia Radiation induced angiosarcoma of the breast Radiation induced meningioma Radiation leukemia Radiation related ... syndrome Radiophobia Radioulnar synostosis mental retardation hypotonia Radioulnar synostosis retinal pigment abnormalities ... cancer Radiation syndromes Radiation-induced brachial plexopathy Radiation-induced lumbosacral plexopathy Radiculomegaly of ... Retinohepatoendocrinologic syndrome Retinopathy anemia CNS anomalies Retinopathy aplastic anemia neurological abnormalities ...
Reversible Encephalopathy Syndrome Radiation-induced brain edema Post-surgical changes Amyloid-related imaging abnormalities ... Radiation-induced brain edema (RIBE) is a potentially life threatening complication of brain tissue radiation and is ... "Radiation-Induced Edema After Single-Fraction or Multifraction Stereotactic Radiosurgery for Meningioma: A Critical Review". ... Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in neuroimaging of Alzheimer's disease patients ...
Fukushima Daiichi nuclear disaster casualties
... including cognitive impairment attributable to within the womb radiation exposure. As no radiation induced inherited effects/ ... No increase is expected in the incidence of congenital or developmental abnormalities, ... indicated that the residents of the area who were evacuated were exposed to so little radiation that radiation induced health ... Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ...
In 1938 Sax published a paper entitled "Chromosome Aberrations Induced by X-rays," which demonstrated that radiation could ... a chromosome abnormality. The paper is thought to mark the beginning of the field of radiation cytology, and led him to be ... noted for his research in cytogenetics and the effect of radiation on chromosomes. Sax was born in Spokane, Washington in 1892 ... called the "father of radiation cytology." Sax bred new varieties of ornamental trees and shrubs including Malus species (both ...
UV light can induce adjacent pyrimidine bases in a DNA strand to become covalently joined as a pyrimidine dimer. UV radiation, ... See also: Chromosome abnormality. By effect on structureEdit. Five types of chromosomal mutations. ... Ionizing radiation. Exposure to ionizing radiation, such as gamma radiation, can result in mutation, possibly resulting in ... Induced mutationEdit. Induced mutations are alterations in the gene after it has come in contact with mutagens and ...
Cellular mechanisms will repair some of this damage, but some repairs will be incorrect and some chromosome abnormalities will ... Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors ... Children and adolescents are twice as likely to develop radiation-induced leukemia as adults; radiation exposure before birth ... It was the observation of the earliest radiologists that led to the recognition of radiation-induced skin cancer-the first ...
Bioremediation of radioactive waste
Radiation tests in model organisms that determine the effects of high radiation on animals and plants are: Chromosomal ... These compounds mutate DNA strands and produce genetic damage, inducing newly lysis and subsequent cell death. Its action on ... Reproductive deficiencies: sterility, reduction in fecundity, and occurrence of developmental abnormalities or reduction in ... If radiation, likewise, is received in small doses over long periods of time, the consequences can be equally severe. It is ...
Fukushima Daiichi nuclear disaster casualties
... including cognitive impairment attributable to within the womb radiation exposure. As no radiation induced inherited ... No increase is expected in the incidence of congenital or developmental abnormalities, ... Now radiation in Japan is as bad as radiation level is raised to 7 for only the second time in history' Daily Mail 12 April ... Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ...
If the abnormality involves a single step in the absorptive process, as in primary lactase deficiency, or if the disease ... Prolonged malnutrition may induce amenorrhea, infertility, and impotence. Edema and even ascites may reflect hypoproteinemia ... Radiation enteritis. *Systemic sclerosis and collagen vascular diseases. *Short bowel syndrome. Due to surgical structural ... ERCP will show pancreatic and biliary structural abnormalities.. Other investigationsEdit. *75SeHCAT test to diagnose bile acid ...
Cellular mechanisms will repair some of this damage, but some repairs will be incorrect and some chromosome abnormalities will ... Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors ... Children and adolescents are twice as likely to develop radiation-induced leukemia as adults; radiation exposure before birth ... Ionizing radiation exposure of the population of the United States : recommendations of the National Council on Radiation ...
Radiation Radiation-induced hypopituitarism mainly affects growth hormone and gonadal hormones. In contrast, ... leading to sex hormone abnormalities. Growth hormone deficiency is more common in people with an underlying tumor than those ... "Radiation-induced hypopituitarism". Endocr. Relat. Cancer. 16 (3): 733-72. doi:10.1677/ERC-08-0231. PMID 19498038.. ... deficiencies are the least common among people with radiation-induced hypopituitarism. Changes in prolactin-secretion is ...
Marginal zone B-cell lymphoma
These genomic abnormalities include the following. Chromosomal abnormalities such as: 1) trisomy of chromosome 3 (24% of cases ... Radiation therapy to the stomach and surrounding (i.e. peri-gastric) lymph nodes has been used to successfully treat: a) ... This gene's product, tumor necrosis factor, alpha-induced protein 3, functions to impair the activation of NF-κB. 2) Gain-of- ... The acquired genomic abnormalities found in EMZL along with the frequency of occurrence in specific EMZL subtypes include the ...
List of MeSH codes (G03)
... radiation effects MeSH G03.850.810.300.360 - radiation injuries MeSH G03.850.810.300.360.031 - abnormalities, radiation-induced ... radiation genetics MeSH G03.850.810.370 - radiation monitoring MeSH G03.850.810.370.310 - film dosimetry MeSH G03.850.810.370. ... radiation MeSH G03.850.110.285 - accidents, radiation MeSH G03.850.110.320 - accidents, traffic MeSH G03.850.110.500 - drowning ... radiation dosage MeSH G03.850.810.250.180 - dose-response relationship, radiation MeSH G03.850.810.250.275 - relative ...
Albert J. Fornace Jr.
Mammalian genes induced by radiation; activation of genes associated with growth control. Annual Rev. Genetics 26: 507-526, ... DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum. ... Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One 7: e42224, 2012. Mironova, N. ... In the radiation field he has received multiple awards including the Radiation Research Society Excellence in Mentoring Award ...
3D reconstruction from multiple images
... they can induce high radiation doses which is a risk for patients with certain diseases. Methods based on MRI are not accurate ... The 2-D imaging has problems of anatomy overlapping with each other and don't disclose the abnormalities. The 3-D imaging can ... This method uses X-ray images for 3D Reconstruction and to develop 3D models with low dose radiations in weight bearing ... So, we discuss the following methods which can be performed while standing and require low radiation dose. Though these ...
... the risks of more frequent mammograms include a small but significant increase in breast cancer induced by radiation. ... A clinical or self breast exam involves feeling the breast for lumps or other abnormalities. Clinical breast exams are ... Radiation can also be given at the time of operation on the breast cancer. Radiation can reduce the risk of recurrence by 50-66 ... Surgery, radiation therapy, chemotherapy, hormonal therapy, targeted therapy. Prognosis. Five-year survival rate ~85% (US, ...
This allows for the imaging of the both jaws in a single two-dimensional image as well as reduced radiation; this is reserved ... Macrodontia is not an abnormality which occurs abruptly during adulthood, rather, it happens while the teeth grow. Causes of ... Malocclusion resulting in an irregular bite that induces severe jaw joint pain. Cavities development due to the irregularity of ... The 3D CBCT imaging technique must be as targeted to the area in question as possible as to minimize the exposure of radiation ...
"Severe and Unrecognized Dental Abnormalities After Drug-Induced Epidermal Necrolysis". Arch. Dermatol. 145 (11): 1332-1333. doi ... "Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study". ... Environmental causes involving exposure to PCBs (ex.dioxin), radiation, anticancer chemotherapeutic ... A relationship was also postulated between abnormalities of the brainstem and the presence of agenesis. ...
Colina, a enciclopedia libre
2010). "Biodistribution and radiation dosimetry of [(11)C]choline: a comparison between rat and human data". European Journal ... 2010). "T2 relaxation time abnormalities in bipolar disorder and schizophrenia". Magnetic Resonance in Medicine 63 (1): 1-8. ... beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced ...
... toxins and radiation-induced Associated conditions:connective tissue disease, HIV infection WHO Group I" - Persistent pulmonary ... Sleep-disordered breathing Alveolar hypoventilation disorders Chronic exposure to high altitude Developmental abnormalities WHO ... Prolonged hypoxia also induces the transcription factor HIF1A, which directly activates downstream growth factor signaling that ... Lawrie, Allan (2014). "The role of the osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the ...
Lower gastrointestinal bleeding
A clotting abnormality and low platelet concentration in the blood should be immediately corrected if possible. Platelets ... and radiation proctitis; nonsteroidal anti-inflammatory drug (NSAID) use is a risk factor for diverticular bleeding and NSAID- ... induced colonic ulcer; and recent colonoscopy with polypectomy suggests postpolypectomy bleeding. Patients should be asked ... may be required to completely reverse clotting abnormalities, depending on the initial prothrombin time. Recombinant activated ...
Given that significant doses of radiation are harmful, even deadly (i.e. radiation-induced cancer, and acute radiation syndrome ... a dose much lower than that which could induce embryonic abnormalities or other non-stochastic effects, there was an observed ... The LNT model therefore suggests that radiation exposure from naturally occurring background radiation may be harmful. There is ... of radiation security proposed by the U.S. National Council on Radiation Protection and Measurements (NCRP) in 1949. The "no- ...
Acute myeloid leukemia
Specific cytogenetic abnormalities can be found in many people with AML; the types of chromosomal abnormalities often have ... However, GATA2 deficiency-induced AML may first appear in children or adults. The first clue to a diagnosis of AML is typically ... High amounts of ionizing radiation exposure can increase the risk of AML. Survivors of the atomic bombings of Hiroshima and ... The specific genetic abnormalities causing AML usually vary between those who develop the disease as a child versus an adult. ...
Non-ionizing radiation. Whether or not non-ionizing radiation causes leukemia has been studied for several decades. The ... In addition to these genetic issues, people with chromosomal abnormalities or certain other genetic conditions have a greater ... Saven, A; Burian, C; Adusumalli, J; Koziol, J. A. (1999). "Filgrastim for cladribine-induced neutropenic fever in patients with ... Non-Ionizing Radiation, Part 1: Static and Extremely Low-Frequency (ELF) Electric and Magnetic Fields (IARC Monographs on the ...
Structural abnormalities of the kidneys are identified with imaging tests. These may include Medical ultrasonography/ultrasound ... Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ...
The FLP gene can then be induced selectively, commonly using either the heat shock promoter or the GAL4/UAS system. The ... Exogenous factors include nicotine and UV radiation. Somatic mosaics have been created in Drosophila using X‑ray treatment ... "Chromosome abnormalities". Human Molecular Genetics (2nd ed.). New York: Wiley-Liss. ISBN 1-85996-202-5. PMID 21089233.. [page ... Such mosaics were originally created by irradiating flies heterozygous for a particular allele with X-rays, inducing double- ...
Both positive and negative results have been reported with adjuvant radiation therapy in this setting, and ... Congenital liver abnormalities, such as Caroli's syndrome (a specific type of five recognized choledochal cysts), have been ... Lipshutz, GS; Brennan, TV; Warren, RS (November 2002). "Thorotrast-induced liver neoplasia: a collective review". Journal of ... Adjuvant chemotherapy and radiation therapyEdit. If the tumor can be removed surgically, people may receive adjuvant ...
Cardiovascular late side effects have been termed radiation-induced heart disease (RIHD) and radiation-induced vascular disease ... However, double-stranded DNA breaks are much more difficult to repair, and can lead to dramatic chromosomal abnormalities and ... "Intensity Modulated Radiation Therapy". Irsa.org. Retrieved 2012-04-20.. *^ Hall EJ, Wuu CS (2003). "Radiation-induced second ... and can also cause radiation cystitis when the bladder is affected.. Radiation-induced polyneuropathy. Radiation treatments are ...
Epigenetics of neurodegenerative diseases
"Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3". ... sometimes leading to behavioral abnormalities (as with PD), and, ultimately, neuronal death, resulting in dementia. ... "Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration" ... "Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's ...
"Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects". ... Beckwith-Wiedemann syndrome is also associated with genomic imprinting, often caused by abnormalities in maternal genomic ... Fluoroquinolone antibiotics induce epigenetic changes in mammalian cells through iron chelation. This leads to epigenetic ... It is in this latter sense that they can be viewed as epigenetic agents capable of inducing a phenotypic change without a ...
These gait patterns are among the most common gait abnormalities in children with cerebral palsy. However, orthopaedic ... exposure to radiation, infection, fetal growth restriction), hypoxia of the brain (thrombotic events, placental conditions), ... constraint-induced movement therapy, context-focused therapy, fitness training, goal-directed training, hip surveillance, home ... functional gastrointestinal abnormalities contributing to bowel obstruction, vomiting, and constipation may also arise. Adults ...
Radiation acne. Radiation-induced cancer. Radiation recall reaction. Radiation-induced erythema multiforme. Radiation-induced ... They are distinguished by the underlying genetic abnormality. Types I and II are caused by mutations in the SERPING1 gene, ... Radiation. Radiation poisoning. Radiation burn. Chronic radiation keratosis. Eosinophilic, polymorphic, and pruritic eruption ... ACE inhibitors can induce angioedema. ACE inhibitors block the enzyme ACE so it can no longer degrade bradykinin; ...
Robergs, R; Ghiasvand, F; Parker, D (2004). "Biochemistry of exercise-induced metabolic acidosis". Am J Physiol Regul Integr ... showing a large degree of radiation for muscle cells. Through this divergence of the Z-disc, Steimetz et al. argue that there ... as well as genetic testing to identify DNA abnormalities associated with specific myopathies and dystrophies. ... Examples include cancer and AIDS, which induce a body wasting syndrome called cachexia. Other syndromes or conditions that can ...
The primary risk from exposure to 131I is an increased risk of radiation-induced cancer in later life. Other risks include the ... Studies of chronically exposed workers though have thus far failed to detect any abnormalities of thyroid function, including ... of its energy and radiation dose is via gamma radiation. However, since the other 90% of radiation (beta radiation) causes ... About 90% of its radiation damage to tissue is via beta radiation, and the rest occurs via its gamma radiation (at a longer ...
سرطان پروستات - ویکیپدیا، دانشنامهٔ آزاد
Alpharadin uses bone targeted Radium-223 isotopes to kill cancer cells by alpha radiation.[unreliable medical source?] It ... Digital rectal examination (DRE) may allow a doctor to detect prostate abnormalities. Cystoscopy shows the urinary tract from ... 5-LOX can be induced by pro-inflammatory stimuli and is expressed in epithelial cancers including lung, prostate, breast, and ... Active surveillance, surgery, radiation therapy, hormone therapy, chemotherapy. Prognosis. 5-year survival rate 99% (US) ...
Acute lymphoblastic leukemia
Radiation therapyEdit. Radiation therapy (or radiotherapy) is used on painful bony areas, in high disease burdens, or as part ... Induce absence of other signs and symptoms of the disease.. Must monitor closely for tumor lysis syndrome after initiating ... Laboratory tests that might show abnormalities include blood count, kidney function, electrolyte, and liver enzyme tests. ... physicians commonly utilized radiation in the form of whole-brain radiation for central nervous system prophylaxis, to prevent ...
... and patients with other risk factors are at a higher risk of experiencing iodine-induced thyroid abnormalities. In ... Exposure to radiation. *Increased intake/plasma levels of goitrogens, such as calcium ...
Childbirth in Japan
Having an abortion due to fetal abnormalities is very rare. Some theorize that the reason for this is because the role of ... A 2005 study by Osaka University Graduate School of Medicine reported that there were 341,588 induced abortions in 2001. In ... Kojima, Shuji (2014). "Effect of ionizing radiation on the living body". Yakugaku Zasshi. J-STAGE. 134 (2): 155-161. doi: ... page needed] Baba, Sachiko; Tsujita, Satoshi; Morimoto, Kanehisa (January 2005). "The analysis of trends in induced abortion in ...
Radiation induced cognitive decline. *Radiotherapy. *Virotherapy. References. *^ a b c d e f Corrie PG, Pippa G. (2008 ... The long-term effects of exposure include chromosomal abnormalities and infertility.:38 ... a b Windebank AJ & Grisold W. Chemotherapy-induced neuropathy. Journal of the Peripheral Nervous System. 2008 Mar;13(1):27-46. ... Trüeb RM (Mar 2009). "Chemotherapy-induced alopecia". Seminars in Cutaneous Medicine and Surgery. 28 (1): 11-4. PMID 19341937. ...
Growth hormone deficiency
GHD can be present at birth or develop later in life. Causes may include genetics, trauma, infections, tumors, or radiation ... "Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone + arginine as provocative tests for ... Lipid abnormalities, particularly raised LDL cholesterol. *Increased levels of fibrinogen and plasminogen activator inhibitor ... damage to the pituitary from radiation therapy to the head (e.g. for leukemia or brain tumors), from surgery, from trauma, or ...
Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting ... Immunoassays can use the basic antibody - antigen binding as the basis to produce an electro-magnetic or particle radiation ... either treatment-induced or spontaneous, it can be influenced by the genetic variants carried by the individual patients. For ... exposure to ionizing radiation, or as a result of an infectious disease with immunosuppressive activity (such as with measles, ...
In animal model studies, furthermore, carbon monoxide reduced the severity of experimentally induced bacterial sepsis, ... abnormalities in its metabolism have been linked to a variety of diseases, including neurodegenerations, hypertension, heart ... atmosphere of Venus carbon monoxide occurs as a result of the photodissociation of carbon dioxide by electromagnetic radiation ... "Pressure-Induced Polymerization of Carbon Monoxide: Disproportionation and Synthesis of an Energetic Lactonic Polymer" ...
Upper gastrointestinal series
Radiographic examinations involve radiation exposure in the form of X-rays. Although barium ions are toxic, their use is ... Normal barium swallow fluoroscopic image, showing the ingested barium sulfate being induced down the oesophagus by peristalsis. ... It has poor sensitivity for subtle abnormalities but is more sensitive in detecting esophageal webs and rings than gastroscopy. ... Barium contrast is more sensitive in the demonstration of subtle mucosa and sub-mucosa abnormalities but computer tomography is ...
In many cases, it is unclear whether the gluten-induced bowel disease is a causative factor or whether these conditions share a ... giardiasis and radiation enteritis. While positive serology and typical biopsy are highly suggestive of coeliac disease, lack ... "Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration". Br Med J. 1 (6000): 11-13. doi:10.1136/bmj. ... "Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3" ...
... including the risk of radiation induced cancer - a four-phase abdominal CT gives the same radiation dose as 300 chest X-rays ( ... A variety of techniques are used, depending on the suspected abnormality. For evaluation of chronic interstitial processes ( ... Radiation dose unitsEdit. The radiation dose reported in the gray or mGy unit is proportional to the amount of energy that the ... the radiation dose associated with a routine abdominal CT has a radiation dose similar to 3 years average background radiation ...
Radiation. Main article: Radiation-induced cancer. Up to 10% of invasive cancers are related to radiation exposure, including ... The classical view of cancer is a set of diseases that are driven by progressive genetic abnormalities that include mutations ... Medical use of ionizing radiation is a small but growing source of radiation-induced cancers. Ionizing radiation may be used to ... Radiation. Radiation therapy involves the use of ionizing radiation in an attempt to either cure or improve symptoms. It works ...
... though exposed to substantial amounts of radiation, later had children with no higher incidence of abnormalities/birth defects ... It was developed near the end of the 1950s by Chemie Grünenthal as a sleep inducing aid and antiemetic. Because of its ability ... cranofacial abnormalities, brain damage, intellectual disability, heart disease, kidney abnormality, skeletal ... Radiation. For the survivors of the atomic bombing of Hiroshima and Nagasaki, who are known as the Hibakusha, no ...
Cutaneous, ocular, and neurologic abnormalities in 830 published cases". Archives of dermatology. 123 (2): 241-50. doi:10.1001/ ... TTD also affects the mother of the affected child during pregnancy, when she may experience pregnancy-induced high blood ... NER pathway but produces a DNA polymerase that allows accurate translesion synthesis of DNA damage resulting from UV radiation ... Misrepair-accumulation aging theory suggests that the abnormality of tissue structure is the common point between ...
Radiation therapyEdit. The goal of radiation therapy is to kill tumor cells while leaving normal brain tissue unharmed. In ... Atypia: an indication of abnormality of a cell (which may be indicative for malignancy). Significance of the abnormality is ... Brain stem: Tumors on this can cause seizures, induce endocrine problems, respiratory changes, visual changes, headaches and ... Chemotherapy is often used in young children instead of radiation, as radiation may have negative effects on the developing ...
ഹിപ്പോകാംപസ് - വിക്കിപീഡിയ
Boyer P, Phillips JL, Rousseau FL, Ilivitsky S (Apr 2007). "Hippocampal abnormalities and memory deficits: new evidence of a ... Huerta PT, Lisman JE (Aug 1993). "Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced ... Optic radiation. *Corona radiata. *External capsule. *Extreme capsule. *Pallidothalamic tracts: Thalamic fasciculus *Ansa ...
As a consequence, p53 cannot induce apoptosis, since it cannot induce the expression of proapoptotic proteins. The adenovirus ... The binding of nuclear receptors by glucocorticoids, heat, radiation, nutrient deprivation, viral infection,[20 ... TNF-/- mice develop normally and have no gross structural or morphological abnormalities. However, upon immunization with SRBC ... HIV-1 expression induces tubular cell G2/M arrest and apoptosis. The progression from HIV to AIDS is not immediate or even ...
topic:"Abnormalities, Radiation-Induced - epidemiology" found 59 records • Arctic Health
Abnormalities, Radiation-Induced - epidemiology Accidents, Radiation Autopsy Central Nervous System - abnormalities Croatia - ... Abnormalities, Radiation-Induced - epidemiology Accidents, Radiation Germany - epidemiology Humans Infant, Newborn Odds Ratio ... Abnormalities, Radiation-Induced - epidemiology Accidents, Radiation Cleft Lip - epidemiology Cleft Palate - epidemiology Cross ... Abnormalities, Radiation-Induced - epidemiology - genetics Accidents, Radiation Down Syndrome - epidemiology - genetics Humans ...
Clinical Trial on Abnormalities, Radiation-Induced: Mouthrinse with HcT20 - Clinical Trials Registry - ICH GCP
Radiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy
Conclusion: The risk of radiation induced myocardial perfusion abnormality in patients treated with CRT on the left hemi thorax ... A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of ... It is reasonable to minimize the volume of the heart being in the field of radiation employing didactic radiation planning ... Six months after radiation therapy, all patients underwent cardiac SPECT for the evaluation of myocardial perfusion. Results: A ...
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer - Tabular...
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer. The safety ... Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer. ... The Modified ONS Criteria for Radiation-Induced Acute Skin Toxicity will be used for classification of EASRs related to the ... Patients are assessed for acute toxicity by research staff using the ONS Criteria for Radiation-Induced Acute Skin Toxicity at ...
Dr. Andrew Moffat, DO - West Jordan, UT - Undersea & Hyperbaric Medicine | Healthgrades.com
Radiation induced myocardial perfusion abnormalities in patients with left breast cancer: A prospective study with short and...
Conclusion: The radiation induced myocardial perfusion abnormalities in patients with left breast cancer could cause permanent ... 0.3±1.0; p=0.03). The indices of perfusion abnormality normalized in control subjects from baseline to follow up scans (p= 0.05 ... We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty ... They underwent myocardial perfusion scans (MPS) 3 years after the external beam radiation therapy at the bed of modified ...
Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula - Full Text...
Clinically significant laboratory tests abnormalities. *Conditions that limits patient compliance (dementia, psycho- ... Diagnosis of radiation-induced rectovaginal fistula established at least six months after radiation therapy ... Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula. The safety and ... Injection of autologous regenerative cells of adipose tissue for treatment of radiation induced rectovaginal fistulas ...
Late Sequelae in Oncology | SpringerLink
Calcaneal bone sensitive and Calcaneal bone swelling and Heel burning sensation and Throat symptoms - Symptom Checker - check...
Back blister and Eczema and Thoracic blister and Thoracic itch - Symptom Checker - check medical symptoms at RightDiagnosis
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting...
Several lines of evidence have linked limb teratogenesis to radiation-induced apoptosis and to the p53 status in murine fetuses ... Abnormalities, Radiation-Induced / etiology * Abnormalities, Radiation-Induced / metabolism* * Abnormalities, Radiation-Induced ... Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting ... The latter could be involved in radiation-induced apoptosis through activation of the p38 and JNK pathways. Thirdly, we found ...
Protective effect of Liuweidihuang Pills against cellphone electromagnetic radiation-induced histomorphological abnormality,...
Protective effect of Liuweidihuang Pills against cellphone electromagnetic radiation-induced histomorphological abnormality, ... Liuweidihuang Pills can improve cellphone electromagnetic radiation-induced histomorphological abnormality of the testis tissue ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Radiation Effects / Radiation- ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Radiation Effects / Radiation- ...
Ralph A. Pincus, M.D. - University of Rochester Medical Center
Johnson, B.E., Becker, B., Goff, W.B., et al. (1985) Neurologic, Neuropsychologic and Computed Cranial Tomography Scan...
1985) Neurologic, Neuropsychologic and Computed Cranial Tomography Scan Abnormalities in 2- to 10-Year Survivors of Small-Cell ... TITLE: A Risk Coefficient for Radiation-Induced Dementia. AUTHORS: Christopher Busby KEYWORDS: Radiation, Alzheimer, Dementia ... 1985) Neurologic, Neuropsychologic and Computed Cranial Tomography Scan Abnormalities in 2- to 10-Year Survivors of Small-Cell ... Since ionizing radiation is known to kill brain cells in laboratory culture and to affect hippocampal neurogenesis in animal ...
radiation injury | pathology | Britannica.com
Tissue damage or changes caused by exposure to ionizing radiation -namely, gamma rays, X-rays, and such high-energy particles ... Many kinds of radiation-induced abnormalities have been observed in experimentally irradiated rodents. A large number of these ... radiation: Major types of radiation injury. Any living organism can be killed by radiation if exposed to a large enough dose, ... For further discussion, see radiation: Biologic effects of ionizing radiation.. Radiation injury occurs in various forms, with ...
Survivorship: Late Effects After Radiation for Non-Hodgkin Lymphoma (Chest/Mediastinum/Neck) | OncoLink
This article provides information about possible late effects after radiation treatment to the chest, mediastinum or neck for ... Taunk, N. K., Haffty, B. G., Kostis, J. B., & Goyal, S. (2015). Radiation-Induced Heart Disease: Pathologic Abnormalities and ... Wei, J., Meng, L., Hou, X., Qu, C., Wang, B., Xin, Y., & Jiang, X. (2018). Radiation-induced skin reactions: Mechanism and ... Late Effects After Radiation to the chest/mediastinum/neck for Non-Hodgkin Lymphoma Side effects from radiation treatment are ...
Mouth symptoms - RightDiagnosis.com
Aberrant subclavian artery abnormality ... difficulty swallowing, hoarseness*Abnormalities, Radiation-Induced ... swallowing ... Alcohol-Induced Disorders ... vomiting*Alcohol-induced hypertension ... shortness of breath, vomiting*Alcohol-induced pseudo- ... Orofacial Cleft ... dental abnormalities*Orofacial Cleft 1 ... dental abnormalities*Orofacial Cleft 10 ... dental abnormalities ... Auricular abnormalities -- cleft lip with or without cleft palate -- ocular abnormalities ... cleft palate, cleft lip*Auriculo- ...
KAKEN - Research Projects | Histone signaling network in DNA damage response (KAKENHI-PLANNED-22131004)
Presentation] A new system for analyzing ionizing radiation-induced chromosome abnormalities2011. *. Author(s). Shi L. ... Journal Article] Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage.2015. *. Author(s) ... Presentation] The role of histone H2AX eviction in DNA damage-induced checkpoint activation2011. *. Author(s). 井倉毅 ... Presentation] The role of chromatin dynamics in DNA damage-induced checkpoint activation2012. *. Author(s). 井倉 毅 ...
Crack synchronization of chaotic circuits under field coupling | SpringerLink
Ma, J., Wu, F.Q., Hayat, T., et al.: Electromagnetic induction and radiation-induced abnormality of wave propagation in ... Wu, J., Xu, Y., Ma, J.: Levy noise improves the electrical activity in a neuron under electromagnetic radiation. PLoS One 12, ... Majhi, S., Perc, M., Ghosh, D.: Chimera states in uncoupled neurons induced by a multilayer structure. Sci. Rep. 6, 39033 (2016 ... Ma, J., Wu, F.Q., Wang, C.N.: Synchronization behaviors of coupled neurons under electromagnetic radiation. Int. J. Mod. Phys. ...
A Risk Coefficient for Radiation-Induced Dementia
Since ionizing radiation is known to kill brain cells in laboratory culture and to affect hippocampal neurogenesis in animal ... The finding suggests that natural background external exposures to ionizing radiation are partly responsible for the ... conventionally employed for assessing cancer risk following radiation exposure, is extended to dementia to find a risk ... The effect of ionising radiation exposure on dementia is approached by applying the causation models of John Stuart Mill and of ...
RADIATION-INDUCED CANCER FROM LOW-DOSE EXPOSURE, AN INDEPENDENT ANALYSIS, 1990, References
"Significance of Chromosome Abnormalities," pp.281-289 in Boice84. Ber85 Beral, Valerie + Hazel Inskip + Patricia Fraser + ... "Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes," RADIATION ... Radiation-Induced Cancer from Low-Dose Exposure,. An Independednt Analysis. Chapter 36 has its own Reference List Alex88a ... INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 53, No.1: 39-48. Wolff89 Wolff, Sheldon, August 11, 1989. "Are Radiation-Induced ...
Longitudinal Diffusion Tensor Magnetic Resonance Imaging Study of Radiation-Induced White Matter Damage in a Rat Model | Cancer...
No gross neurologic abnormalities were observed in other rats.. Longitudinal Trend of DTI Indices and Dose Effect. Of all DTI ... radiation. Introduction. Radiation-induced white matter (WM) damage is considered a major contributory factor of treatment- ... monitor radiation-induced WM damage in vivo and can be used as a biomarker for the noninvasive evaluation of radiation-induced ... of radiation-induced WM damage and our results support the use of DTI as a biomarker to noninvasively monitor radiation-induced ...
Exhibit Tags: nobel / Creator: Pauling, Linus, 1901-1994 / Format: Text / Genre: Drafts (documents) / Language: English - Linus...
IJMS | Free Full-Text | Laser-Driven Ultrashort Pulsed Electron Beam Radiation at Doses of 0.5 and 1.0 Gy Induces Apoptosis in...
Our data suggest that UPEB radiation produces more complex DNA damage than X-ray radiation, leading to cell death rather than ... We found that the biological action of UPEB-radiation compared to X-rays was characterized by significantly slower γH2AX foci ... In this study, the radiobiological effects of ultrashort pulsed electron beam (UPEB) and X-ray radiation in human lung ... Radiation-induced cytogenetic abnormalities represent an early marker of possible delayed effects [32,33]. In this work the ...
Radiation-Induced Lung Cancers in Murine Models
As this number increases, so does the incidence of secondary, radiation-induced neoplasias, creating a need for therapeutic ... but also a set of reliable animal models to accurately recreate the complex situations of radiation-induced carcinogenesis. The ... as well as methods of induction of radiation-induced lung cancers. Associated molecular pathologies are also included. ... However, this effective treatment comes with risks of its own, and the sheer number of patients that undergo radiation as a ...
Prenatal irradiation and developmental disorders of the brain--present state of investigation and the problem]. | Semantic...
Diffusion Tensor Imaging of Brain Abnormalities Induced by Prenatal Exposure to Radiation in Rodents. *Shigeyoshi Saito, ... Prenatal Irradiation-Induced Hippocampal Abnormalities in Rats Evaluated Using Manganese-Enhanced MRI. *Shigeyoshi Saito, ... Quantitative assessment of central nervous system disorder induced by prenatal X-ray exposure using diffusion and manganese- ...
HON Mother & Child Glossary, Gynaecologic Problems: Menopausal Problems
This page deals with common menopausal problems such as premature menopause, induced menopause and temporary menopause. ... Radiation-induced menopause . Pelvic radiation therapy is more likely to cause permanent ovarian failure if the ovaries receive ... It has been linked to both familial and nonfamilial X-chromosome abnormalities. Premature menopause can also be caused by ... Induced menopause According to CAMS, the term induced menopause is defined as the cessation of menstruation that follows either ...
Eating symptoms - RightDiagnosis.com
Aberrant subclavian artery abnormality ... difficulty swallowing*Abnormalities, Radiation-Induced ... swallowing pain, ... Al Murrah-induced lead poisoning ... loss of appetite*Alarcon-induced lead poisoning ... loss of appetite*Albayaidle-induced ... Drug-induced liver damage -- Iodide ion ... loss of appetite*Drug-induced liver damage -- Isoniazid ... loss of appetite*Drug- ... Drug-induced liver damage -- Sulfonamide ... loss of appetite*Drug-induced liver damage -- Sulfones ... loss of appetite ...
Chordoma Presenting as a "Cold" Lesion on Bone Scintigraphy
Characterization of radiation induced photopenic abnormalities on bone scans. Radiol 1982; 145:161-163.. 5) Jones DC and Cady ... There were no other abnormalities.. Radiation therapy was started, but because of progressive worsening of leg weakness and ... Avascular necrosis, acute osteomyelitis, radiation therapy, frostbite, electrical burns, Gauchers or sickle cell disease (with ...
Changes in smell acuity induced by radiation exposure of the olfactory mucosa.
The effects of ionizing radiation on smell acuity were assessed in 12 patients in whom the olfactory mucosa was exposed to ... radiation in the course of treatment for nasopharyngeal carcinoma or pituitary adenoma. Olfactory detection thresholds for two ... Next Document: Prevalence of incidental abnormalities on computed tomographic scans of the paranasal sinuses.. ... Nasal Mucosa / radiation effects*. Smell / radiation effects*. From MEDLINE®/PubMed®, a database of the U.S. National Library ...
ApoptosisRisk of radiation inducedFibrosisDamageIncidenceChromosomal abnormalitiesMutationsDoseCancerPerfusion abnormalityRadiotherapyTumorsMiceCancersUltravioletMorbidity and mortaSperm head abnormalitiesToxicityAbstractSevereAcuteDoses of radiationOxidativeMorphologicalTherapyChernobylSusceptibilityDepartment of Radiation OncologyCardiacOncologyLungIrradiationHuman FibroblastsInjuryEffectsCellularThyroidCongenitalChemotherapy or radiationNeurologicalGeneElectromagneticTissuesIonizing RadiationFertilityPatientsMalformationNuclearPrevalenceExperimentallyChildren and young adultsSensitivityCharacterizationCataractsExposure to radiofrequencyTreatmentIncreases
- Several lines of evidence have linked limb teratogenesis to radiation-induced apoptosis and to the p53 status in murine fetuses. (nih.gov)
- The latter could be involved in radiation-induced apoptosis through activation of the p38 and JNK pathways. (nih.gov)
- To observe the effect of Liuweidihuang Pills in relieving cellphone electromagnetic radiation -induced histomorphological abnormality, oxidative injury , and cell apoptosis in the rat testis . (bvsalud.org)
- Liuweidihuang Pills can improve cellphone electromagnetic radiation -induced histomorphological abnormality of the testis tissue and reduce its oxidative damage and cell apoptosis . (bvsalud.org)
- We found that the biological action of UPEB-radiation compared to X-rays was characterized by significantly slower γH2AX foci elimination (with a dose of 1 Gy) and strong apoptosis induction (with doses of 0.5 and 1.0 Gy), accompanied by a slight increase in micronuclei formation (dose of 1 Gy). (mdpi.com)
- Overexposure to UV in normal skin will induce p53-dependent apoptosis, which may serve to protect the skin from damaged cells. (medscape.com)
- Basal keratinocytes with mutated TP53 may not respond normally to UV-induced apoptosis, allowing further proliferation and development of new genetic abnormalities. (medscape.com)
- DR5 (also called TRAIL receptor 2 and KILLER) is an apoptosis-inducing membrane receptor for tumor necrosis factor-related apoptosis-inducing ligand (also called TRAIL and Apo2 ligand). (asm.org)
- When exposed to ionizing radiation, DR5-null tissues exhibit reduced amounts of apoptosis compared to wild-type thymus, spleen, Peyer's patches, and the white matter of the brain. (asm.org)
- Death-inducing signaling complex-activated autocleavage of pro-caspase 8 to active caspase 8 allows downstream cleavage of caspases 3, 7, and 6 and BID, leading to the execution of apoptosis ( 22 ). (asm.org)
- p53 signals apoptosis through transactivation of various target genes that can be grouped as inducing apoptosis either intrinsically (via the mitochondria) or extrinsically (via death receptors). (asm.org)
- Mobile phone exposure does not induce apoptosis on spermatogenesis in rats. (emf-portal.org)
- Here, we report experimental evidence of TTF-induced apoptosis and the synergistic antimitotic effect of TTF in combination with ionizing radiation (IR). (virtualtrials.com)
- Cell apoptosis, DNA damage, and mitotic abnormalities were quantified after the application of TTF, and their percentages were markedly increased when TTF was combined with IR. (virtualtrials.com)
Risk of radiation induced4
- If we consider the risk of radiation induced cancer, an effect might not be demonstrated. (arctichealth.org)
- The risk of radiation induced myocardial perfusion abnormality in patients treated with CRT on the left hemi thorax is not low. (ac.ir)
- It is generally accepted that cumulative exposure of greater than 30 Gy results in an increased risk of radiation-induced CAD. (acc.org)
- The risk of radiation-induced heart disease is increased with anterior or left chest irradiation, lack of shielding, higher doses and with concomitant anthracycline chemotherapy. (bcs.com)
- Currently, there is convincing evidence in the scientific literature that the injection of intact autologous SCs into the zone of fibrosis surrounding the chronic radiation ulcer leads to the healing of a wound defect. (clinicaltrials.gov)
- Radiation fields involving the lung can lead to scarring (fibrosis), inflammation (pneumonitis), and restrictive or obstructive lung disease. (oncolink.org)
- Pathogenetic mechanisms in radiation fibrosis. (springer.com)
- RIHD presents clinically several years after irradiation and manifestations include accelerated atherosclerosis, pericardial and myocardial fibrosis, conduction abnormalities, and injury to cardiac valves. (hindawi.com)
- Radiation-induced heart disease can manifest as pathology of the epicardial and endocardial coronary vessels resulting in coronary obstruction, semilunar and atrioventricular valves resulting in stenosis or regurgitation due to valvular fibrosis, myocardium with resultant cardiomyopathy, and conduction system and pericardium with pericardial constriction and inflammation. (acc.org)
- Radiation-induced lung injury, including radiation pneumonitis and radiation fibrosis, is common among patients who have received radiation therapy, and it is the most common treatment-limiting toxicity among patients who receive thoracic radiation. (renalandurologynews.com)
- It typically presents one to six months after therapy, while radiation-associated fibrosis tends to present six to twenty-four months following radiation therapy. (renalandurologynews.com)
- Late radiation-induced lung injury typically presents as pulmonary fibrosis. (renalandurologynews.com)
- These findings are generally visible radiographically by six months, and almost all patients who develop radiation-induced pulmonary fibrosis show evidence by twenty-four months following radiation exposure. (renalandurologynews.com)
- Although individuals with pneumonitis are more likely to develop radiation-associated fibrosis, not all patients who develop fibrosis have a history of radiation pneumonitis. (renalandurologynews.com)
- Radiation-induced cardiac toxicity (RICT) may present as multiple pathologies including myocardial fibrosis, ischemic heart disease, valvular abnormalities and pericarditis . (medworm.com)
- Lomax ME, Folkes LK, O'Neill P. Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. (ac.ir)
- Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). (ac.ir)
- A new strategy for treatment of late radiation damage is to develop methods aimed at stimulating the regenerative capabilities of irradiated tissues. (clinicaltrials.gov)
- Since the main pathogenetic mechanism of the development of late radiation damage is the death or damage of the replicative mechanism of stromal cells (SC), a justified approach can be considered as transplantation of intact SC. (clinicaltrials.gov)
- Altogether, our data suggest that transcriptional modulations of apoptotic, inflammation, stress, and DNA damage players are early events in radiation-induced forelimb defects. (nih.gov)
- Radiation injury , tissue damage or changes caused by exposure to ionizing radiation -namely, gamma rays , X-rays , and such high-energy particles as neutrons, electrons, and positrons. (britannica.com)
- Journal Article] Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage. (nii.ac.jp)
- Discussion of the health effects of ionising radiation (IR) has, until recently, focused on cancer and genetic damage as assessed largely through the concept of "absorbed dose" and rates of illness and congenital effects revealed by the Japanese Life Span Study (LSS) of the survivors of the Hiroshima and Nagasaki bombs. (scirp.org)
- Radiation-induced white matter (WM) damage is a major side effect of whole brain irradiation among childhood cancer survivors. (aacrjournals.org)
- We evaluate longitudinally the diffusion characteristics of the late radiation-induced WM damage in a rat model after 25 and 30 Gy irradiation to the hemibrain at 8 time points from 2 to 48 weeks postradiation. (aacrjournals.org)
- We hypothesize that diffusion tensor magnetic resonance imaging (DTI) indices including fractional anisotropy (FA), trace, axial diffusivity (λ // ), and radial diffusivity (λ ⊥ ) can accurately detect and monitor the histopathologic changes of radiation-induced WM damage, measured at the EC, and that these changes are dose and time dependent. (aacrjournals.org)
- DTI indices reflected the histopathologic changes of WM damage and our results support the use of DTI as a biomarker to noninvasively monitor radiation-induced WM damage. (aacrjournals.org)
- Radiation-induced white matter (WM) damage is considered a major contributory factor of treatment-induced neurotoxicity prevalent among childhood cancer survivors who have undergone whole brain irradiation ( 1 ). (aacrjournals.org)
- Currently, treatment strategies that are being used with the goal to minimize radiation damage include reduction of radiation dose, altered fractionation, use of focal radiotherapy and proton radiotherapy, and improving immobilization so as to reduce planning target volume. (aacrjournals.org)
- Also, radiation is omitted or deferred in children under the age of 3 to 5 years due to the known susceptibility of developing brain tissue to radiation damage ( 3 ). (aacrjournals.org)
- Our data suggest that UPEB radiation produces more complex DNA damage than X-ray radiation, leading to cell death rather than cytogenetic disturbance. (mdpi.com)
- Although UVB is responsible for most of the DNA damage within skin cells that might lead to the promotion of cancers [ 1 - 2 ], however UVC is considered the most lethal form of UV radiation. (mdpi.com)
- Many Nbn mutations result in the production of a truncated protein missing regions required for effectively responding to DNA damage, resulting in a buildup of DNA strand breaks leading to radiation exposure sensitivity. (jax.org)
- While it is well known that high levels of radiation ( i.e. from cancer treatments) can be damaging to cells and tissues and cause significant injury in bone marrow and the digestive tract, there remains to be controversy regarding what specifically triggers this type of damage at a molecular level. (uvic.ca)
- A protein called AIM2 has previously been known for its role in detecting infectious threats, but this recently completed study discovered that it may also play a role in detecting damage in DNA from radiation and cause a particular type of cell death known as pryoptosis. (uvic.ca)
- In animals that were lacking AIM2, it was found that the bone marrow and gastrointestinal tracts had no damage and were protected from radiation. (uvic.ca)
- These wireless devices emit high-frequency microwave radiation, recently demonstrated by European researchers to efficiently inflict the same horrific damage on human cells as X-radiation. (opednews.com)
- 2006). Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands . (rug.nl)
- There are towns around Chernobyl full of the most grossly deformed children because they were damaged in the first 3 months of intrauterine life where limbs grow and brain grows and heart grows and so radiation can damage the cell that is going to form the left half of the brain for instance or the right arm, like Thalidomide did. (topdocumentaryfilms.com)
- Here we show that Nek1 is involved early in the DNA damage response induced by ionizing radiation (IR) and that Nek1 is important for cells to repair and recover from DNA damage. (aacrjournals.org)
- Finally, Nek1-deficient fibroblasts are much more sensitive to the effects of IR-induced DNA damage than otherwise identical fibroblasts expressing Nek1. (aacrjournals.org)
- In this report, we show that Nek1 responds to DNA damage by quickly up-regulating its kinase activity and that cells without functional Nek1 fail to repair their DNA properly and therefore survive poorly after ionizing radiation (IR)-induced DNA damage. (aacrjournals.org)
- It was previously thought that the adverse effects of radiation , one of the only legally sanctioned standards of care for cancer patients, were due only to the damage incurred by genetic material secondary to energy deposition of ionizing radiation (1). (oneradionetwork.com)
- When mammals are dosed with radiation equivalent to or exceeding doses of 4 grays, their un-irradiated cage mates exhibit various adverse effects, including leukopenia, or decreased numbers of white blood cells, which predisposes individuals to infection, alongside other markers of immune suppression and chromosomal damage (1, 17). (oneradionetwork.com)
- Nonetheless, species ranked similarly in sperm abnormalities in unpolluted areas as in Chernobyl, pointing to intrinsic factors underlying variation in sperm damage among species. (royalsocietypublishing.org)
- Thus, we predicted that species with a high risk of sperm competition should have more robust sperm, in this case lower frequencies of radiation-induced damage. (royalsocietypublishing.org)
- By the late 1920s it had become apparent, from the studies of Müller on the fruit fly, Drosophila , that radiation damage from X-rays could cause effects in future generations, and through to the 1950s this was the principle cause for concern at lower radiation doses. (encyclopedia.com)
- One molecule of particular importance in relation to radiation damage is deoxyribonucleic acid (DNA), found in the nucleus of the cell. (encyclopedia.com)
- The gray can be multiplied by a 'weighting factor' to take account of the effectiveness of different radiations in causing damage to tissues. (encyclopedia.com)
- Radiofrequency radiation (900 MHz)-induced DNA damage and cell cycle arrest in testicular germ cells in swiss albino mice. (emf-portal.org)
- Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro. (emf-portal.org)
- The acute responses of UV radiation are DNA damage, lipid peroxidation and protein crosslinking that lead to erythema, sunburn and immunosuppression. (redorbit.com)
- In addition, conventional 2D radiation can induce severe damage such as bone necrosis, temporal lobe necrosis, cranial neuropathies, and trismus. (amazonaws.com)
- TES," a nitroxide stable free radical derivative, was tested as a central nervous system contrast enhancer in dogs with experimentally induced unilateral cerebritis or radiation cerebral damage. (ajnr.org)
- The survivors of the atomic-bomb blasts at Hiroshima and Nagasaki, some patients subjected to multiple fluoroscopic chest examinations, and certain groups of radiation workers (e.g., women who painted radium watch and clock dials) have exhibited dose-dependent increases in the incidence of cancer, most notably leukemia and breast cancer . (britannica.com)
- The incidence of mental retardation and reduced head size in such children increased substantially when exposure occurred between the 8th and 15th weeks of gestation, which has been determined to be the age of greatest susceptibility to ionizing radiation. (britannica.com)
- As this number increases, so does the incidence of secondary, radiation-induced neoplasias, creating a need for therapeutic agents targeted specifically towards reduction in the incidence of and treatment of these cancers. (scirp.org)
- As no comprehensive genomic study has addressed the molecular classification of PEComa, we sought to investigate by multiple methodologies the incidence and spectrum of genetic abnormalities and their potential genotype-phenotype correlations in a large group of 38 PEComas. (worldcat.org)
- [ 2 ] Factors leading to an increased incidence of actinic keratosis include cumulative ultraviolet radiation exposure, increasing age, childhood sun exposure, male sex, and residing in latitudes close to the equator. (medscape.com)
- 24-hour esophageal pH--abnormalities associated with a higher incidence of gastroesophageal reflux and esophagitis . (cancernetwork.com)
- In this review, we will discuss radiation-induced coronary artery disease (CAD), focusing primarily on incidence, diagnosis, and management. (acc.org)
- 1,2 The cumulative incidence of radiation-induced CAD is estimated to be nearly 60% in survivors of Hodgkin's lymphoma 40 years after radiation exposure with a relative risk of 3.2-fold compared with the general population. (acc.org)
- Higher incidence of congenital defects like abnormalities in bones, malformation of vital organs including reproductive organs, leukemia, thyroid and bone cancers. (org.in)
- Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly leukemia . (wikipedia.org)
- The most widely accepted model posits that the incidence of cancers due to ionizing radiation increases linearly with effective radiation dose at a rate of 5.5% per sievert . (wikipedia.org)
- Compounded by changes in lifestyle related to excessive outdoor recreational activities, UV radiation has consequently led to a surge in the incidence of skin-related disorders including cancer. (redorbit.com)
- As demonstrated for sporadic thyroid carcinomas ( 8 ), the apparent incidence of radiation-induced thyroid cancer is closely related to the modalities and intensity of screening. (scielo.br)
- Although most studies showed an increased incidence of thyroid cancer in patients who were exposed to radiation during childhood and adolescence, it is important to take into account that the extent of this increase could be determined by the screening procedures used to detect thyroid abnormalities. (scielo.br)
- With this, however, comes a high possibility of chromosomal abnormalities and mutations, so AIM2 is activated to kill the cell entirely. (uvic.ca)
- Radiation induced changes in cell division and increased chromosomal abnormalities were attributed to cellular response to resonance. (cdc.gov)
- Research indicates a wide range of problems in animals that eat irradiated food, including chromosomal abnormalities, a rare form of cancer, and even premature death. (anh-usa.org)
- UV-induced mutations of the tumor suppressor gene TP53 are of major importance in the development of actinic keratosis. (medscape.com)
- PLCD1-modified mice (F0) showed progressive hair loss after birth and the genotype of CRISPR/Cas9-induced mutations in exon 2 of PLCD1 locus, suggesting the sgRNA is effective to cause mutations that lead to hair growth defect. (biomedcentral.com)
- Mutations in genes of the RAD52 group result in an increased sensitivity to ionizing radiation and defects in one or more types of recombination. (asm.org)
- Induced mutagenesis, as opposed to natural mutagenesis, is when mutations in plants are brought about through exposure to ionizing radiation (such as ultraviolet light or X-rays) or certain chemical agents. (anh-usa.org)
- A significant increase in preterm births occurred among children who were exposed to radiation during the first trimester whose mothers lived in zones 2 and 3, where the external dose rate and estimated surface activity of caesium-137 were highest. (arctichealth.org)
- This study was held at the buccal cancer center of UNESP and involved thirty one patients (n = 31) divided into two groups: Group 1 had seventeen patients (n = 17) submitted to fractioned radiation treatment in the head and neck region at the total dose of 7.000 cGy and had Hct20 during the treatment. (ichgcp.net)
- There is persuasive evidence from the epidemiological studies of a large cohort of female nuclear workers that ionising radiation exposure is associated with significant low dose region dose-dependent increases in rates of dementia. (scirp.org)
- Radiation injury occurs in various forms, with each type dependent on the ionizing radiation involved, its penetrating ability, the portion of the body exposed, the duration of exposure, and the total dose. (britannica.com)
- Any living organism can be killed by radiation if exposed to a large enough dose, but the lethal dose varies greatly from species to species. (britannica.com)
- Indeed, the currently accepted cancer risk and genetic risk per unit dose applied by governments, following advice from radiation risk agencies like the International Commission on Radiological Protection (ICRP), is largely based on the LSS . (scirp.org)
- Effect of Low-Dose Irradiation upon T Cell Subsets Involved in the Response of Primed A/J Mice to SaI Cells," INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 53, No.1: 103-118. (ratical.org)
- Risk of Radiation at Low Dose Rates," LANCET 1981, 1: 430-433. (ratical.org)
- Mortality and Radiation Dose, 1950-1966" ( TR-11-70 ). (ratical.org)
- Mortality and Radiation Dose, 1950-1974" (RERF TR-1-77 ). (ratical.org)
- Also, FA reduction correlates with known risk factors of neurotoxicity, including radiation dose and age at irradiation ( 11 ), and with cognitive outcome ( 12 ), suggesting that FA is able to reflect WM injury that is associated with treatment-induced neurotoxicity. (aacrjournals.org)
- To decrease late complications, treatment has gradually evolved toward shorter-duration chemotherapy with use of lower-dose, shorter-duration radiation therapy. (aafp.org)
- Although radiation doses to a fetus tend to be lower than the dose to the mother, due to protection from the uterus and surrounding tissues, the human embryo and fetus are sensitive to ionizing radiation at doses greater than 0.1 gray (Gy). (cdc.gov)
- Health effects to a fetus from radiation exposure depend largely on the radiation dose. (cdc.gov)
- Dose from an external source of radiation to the mother's abdomen. (cdc.gov)
- Hospital medical physicists and health physicists are good resources for expertise in estimating the radiation dose to the fetus. (cdc.gov)
- In addition to the hospital or clinic's specialized staff, physicians may access resources from or contact the following organizations for assistance in estimating fetal radiation dose. (cdc.gov)
- The International Commission on Radiological Protection's "Publication 84: Pregnancy and Medical Radiation" external icon [ICRP2000] provides fetal dose estimations from medical exposures to pregnant women. (cdc.gov)
- Once the fetal radiation dose is estimated, potential health effects can be assessed. (cdc.gov)
- When the radiation dose reaches 1,000 cGy, the patient may begin to experience mild to moderate dryness of the mouth [1-3]. (cancernetwork.com)
- Risk factors for radiation-induced CAD include age at exposure, total radiation dose, volume of tissue exposed, and lack of cardiac shielding techniques. (acc.org)
- 2 Radiation dose has been directly associated with risk of developing radiation-induced CAD, although no universally "safe" threshold has been identified, likely due to patient comorbidity and anatomic heterogeneity. (acc.org)
- 7 A study of 2,168 women undergoing radiation therapy for breast cancer in Sweden and Denmark between 1958 and 2001 demonstrated a linear increase in rates of major coronary events at a rate of 7.4% per Gy, with a mean dose to the whole heart of 4.9 Gy. (acc.org)
- A graph summarizing data from 30 studies reporting the Specific Absorption Rate (SAR a measure of radiofrequency radiation dose) can be found in Figure 2, on the final page. (scribd.com)
- Radiation effects depend on a number of factors like radiation dose, dose rate, intensity of radiation, criticality and radio-sensitivity of the exposed parts. (org.in)
- Nausea, vomiting, diarrhoea, loss of appetite and uneasiness are initially noticed and depending on the radiation dose, the severity of symptoms may increase. (org.in)
- The radiation dose yielding 50 per cen lethality (LD50) in the exposed human population, is considered at about 3.0 - 3.5 Gray (Gy) and people engaged in rescue operations are often allowed to receive doses limiting to 0.5 to 1.0 Gy. (org.in)
- In one experiment, radiation-naive rodents placed in the same cage with rodents that had previously received a single dose of ionizing radiation to one brain hemisphere revealed that similar or even greater effects were observed in the cage mates relative to the irradiated rats, illuminating that signal transmission occurred between two live animals (1). (oneradionetwork.com)
- The principal quantity used to assess exposure to radiation is the absorbed dose, with the unit of the gray, Gy (equivalent to a deposition of energy of 1 Joule/kg). (encyclopedia.com)
- For most people the main source of radiation exposure is natural background, which, in the UK, gives a radiation dose of about 2.2 millisieverts (mSv) a year. (encyclopedia.com)
- The effects of ionizing radiation soon appear if a person receives a sufficient radiation dose. (encyclopedia.com)
- A very high radiation dose to the whole body can cause death within a matter of weeks. (encyclopedia.com)
- It is often the single largest contributor to an individual's background radiation dose, and is the most variable from location to location. (wikipedia.org)
- In industrialized countries, Medical imaging contributes almost as much radiation dose to the public as natural background radiation. (wikipedia.org)
- In accordance with ICRP recommendations, most regulators permit nuclear energy workers to receive up to 20 times more radiation dose than is permitted for the general public. (wikipedia.org)
- Type 2 effects are caused by Trastuzumab and are not dose related and there are no ultra-structural abnormalities. (bcs.com)
- The association between radiation exposure and the occurrence of thyroid cancer has been well documented, and the two main risk factors for the development of a thyroid cancer are the radiation dose delivered to the thyroid gland and the age at exposure. (scielo.br)
- Radiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy', Asia Oceania Journal of Nuclear Medicine and Biology , 3(1), pp. 3-9. (ac.ir)
- Radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. (ac.ir)
- A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right-sided cancer. (ac.ir)
- 50% of radiation] was significantly higher in patients with left-sided breast cancer. (ac.ir)
- To develop and validate prediction biomarkers for radiation therapy (RT)-induced acute and chronic skin reactions and quality of life in five racial/ethnic groups of breast cancer patients, Whites*, Black/African Americans, Hispanic/Latinos, Asians/Native Hawaiians/Pacific Islanders, and American Indians/Alaskan Natives. (clinicaltrials.gov)
- The external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. (ac.ir)
- The radiation induced myocardial perfusion abnormalities in patients with left breast cancer could cause permanent coronary disease over time. (ac.ir)
- 1985) Neurologic, Neuropsychologic and Computed Cranial Tomography Scan Abnormalities in 2- to 10-Year Survivors of Small-Cell Lung Cancer. (scirp.org)
- Using results from these studies, the Probability of Causation approach (PC), conventionally employed for assessing cancer risk following radiation exposure, is extended to dementia to find a risk coefficient for all ages of 60 per Sievert cumulative exposure over the range 0-100 mSv. (scirp.org)
- Other manifestations of radiation injury are certain forms of cancer . (britannica.com)
- Radiation therapy fields that include breast tissue can lead to breast cancer later on in life. (oncolink.org)
- If you are a man who has had radiation to the chest, you should be aware of your increased risk of getting breast cancer. (oncolink.org)
- The risk of heart failure depends on the amount of radiation you received and what other cancer treatments you had. (oncolink.org)
- Population Heterogeneity Hypothesis on Radiation Induced Cancer," HEALTH PHYSICS 25: 97-104. (ratical.org)
- Pelvic radiation therapy is more likely to cause permanent ovarian failure if the ovaries receive high doses of radiation (such as for treatment of cervical cancer). (hon.ch)
- Radiation therapy is a key weapon in the modern arsenal of cancer treatment. (scirp.org)
- 2006) Intensity-Modulated Radiation Therapy for the Treatment of Oropharyngeal Carcinoma: The Memorial Sloan-Kettering Cancer Center Experience. (scirp.org)
- As overlapping gene fusions involving actionable kinases are emerging in both IMT and lung cancer, we set out to evaluate abnormalities in ALK, ROS1, PDGFRB, NTRK1, and RET by fluorescence in situ hybridization. (worldcat.org)
- EML4-ALK inversion and ROS1 fusions emerge as common fusion abnormalities in IMT, closely recapitulating the pattern seen in lung cancer. (worldcat.org)
- Radiation therapy for head and neck cancer affects the salivary glands located within the field of irradiation. (cancernetwork.com)
- The role of radiation and chemotherapy in adult patients with high-grade brainstem gliomas: results from the National Cancer Database. (mayo.edu)
- Chromosome abnormality journals describes briefly about multiple myeloma also known as plasma cell myeloma or Kahler's disease (after Otto Kahler), is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. (omicsonline.org)
- Historically, Hodgkin's lymphoma and breast cancer treatments have included thoracic radiation therapy, resulting in exposure of cardiac tissues to radiation. (acc.org)
- Early stage breast cancer treatment involves breast conservation surgery and adjuvant/neoadjuvant radiation therapy and confers a 95% 5-year survival rate. (acc.org)
- Meta analyses have shown that the relative risk of developing radiation-induced CAD in patients with breast cancer receiving left versus right chest radiotherapy is higher. (acc.org)
- 5 Taken together, it is clear that patients with thoracic malignancies, such as Hodgkin's lymphoma and breast cancer, treated with radiation therapy have a considerably higher risk of developing radiation-induced CAD compared with the general population. (acc.org)
- Mantle radiation and extended field mantle radiation were the standard of care for several decades for Hodgkin's lymphoma or breast cancer, with radiation exposures significantly higher than 30 Gy. (acc.org)
- More than that, low doses of radiation seem to start the genes responsible with the protection against cancer, therefore the number of cases of cancer in regions with higher than normal background radiation is actually lower. (topdocumentaryfilms.com)
- Also of course, it causes thyroid cancer and lots of other abnormalities. (topdocumentaryfilms.com)
- Organizing pneumonia is also more commonly seen outside of the radiation field than traditional radiation pneumonitis, often in the contralateral lung, and is more common among patients who have received radiation for breast cancer. (renalandurologynews.com)
- In the last quarter century, survival after breast cancer has markedly increased because of advances in earlier detection, hormonal treatments, and chemotherapy and improvements in radiation therapy (RT). (aacrjournals.org)
- Some reports suggest that women with left-sided breast cancer who received adjuvant RT are at greater risk of CVD including stroke due to increased radiation exposure to the heart ( 5-11 ) or to the carotid regions ( 12-15 ), whereas others found no differences in these outcomes due to laterality, possibly due to shorter study observation time ( 16, 17 ). (aacrjournals.org)
- The rationale for evaluating stroke is that the carotid arteries may be included in the radiation fields among women with node-positive breast cancer ( 12 , 14 ). (aacrjournals.org)
- Radiation therapy for thoracic or mediastinal malignant neoplasms, particularly breast cancer and Hodgkin lymphoma, can cause long-term coronary microangiopathy and macroangiopathy. (brainscape.com)
- There is a four- to seven-fold increase in clinically significant, high-grade coronary artery stenosis of the mid and distal left anterior descending coronary artery in women with irradiated left-sided breast cancer compared with those treated with radiation for right-sided breast cancer. (brainscape.com)
- Radiation therapy (RT) is part of definitive treatment for patients with unresectable non-small cell lung cancer (NSCLC). (medworm.com)
- This research may suggest adverse health effects for medical practitioners and family in close proximity to cancer patients receiving radiation. (oneradionetwork.com)
- Dr. Nieman's group has characterized the anatomical phenotypes seen in childhood cancer survivors who were treated with radiation therapy. (utoronto.ca)
- Within just a few years it was realized that high radiation doses from X-rays could cause severe skin burns, cancer in exposed tissues, and even death. (encyclopedia.com)
- This resulted in steps being taken to reduce exposures, although in the early years after their discovery it was assumed that only high radiation doses from X-rays could cause cancer. (encyclopedia.com)
- The principle long-term effect of exposure to low doses of ionizing radiation is now considered to be the induction of cancer. (encyclopedia.com)
- Non-ionizing radio frequency radiation from mobile phones , electric power transmission , and other similar sources have been described as a possible carcinogen by the World Health Organization 's International Agency for Research on Cancer , but the link remains unproven. (wikipedia.org)
- According to the prevalent model, any radiation exposure can increase the risk of cancer. (wikipedia.org)
- Epidemiological evidence shows a clear link between lung cancer and high concentrations of radon, with 21,000 radon-induced U.S. lung cancer deaths per year-second only to cigarette smoking-according to the United States Environmental Protection Agency . (wikipedia.org)
-  Radiation is a more potent source of cancer when it is combined with other cancer-causing agents, such as radon gas exposure plus smoking tobacco. (wikipedia.org)
-   This estimate is criticized by the American College of Radiology (ACR), which maintains that the life expectancy of CT scanned patients is not that of the general population and that the model of calculating cancer is based on total-body radiation exposure and thus faulty. (wikipedia.org)
- In addition to concerns about a recurrence of the cancer for which they were treated, cancer survivors are also at increased risk of developing a second type of cancer because of either their treatment for cancer (e.g., radiation), their genetic or other susceptibility, or some interaction between treatment and genetic susceptibility. (nap.edu)
- As many as two-thirds of survivors will experience a late effect of chemotherapy or radiation, defined as any chronic or late occurring outcome-physical or psychosocial-that persists or develops beyond five years from the diagnosis of the cancer (Garre et al. (nap.edu)
- The indices of perfusion abnormality normalized in control subjects from baseline to follow up scans ( p = 0.05 for summed difference score and p =0.04 for summed stress score). (ac.ir)
- We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. (ac.ir)
- Radiation-induced heart disease (RIHD) is a potentially severe side effect of radiotherapy of thoracic and chest wall tumors if all or part of the heart was included in the radiation field. (hindawi.com)
- Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). (wikipedia.org)
- 1] Stereotactic body radiotherapy (SBRT) is an external beam radiotherapy modality in which large radiation doses are delivered over five or fewer fractions. (medworm.com)
- This notion, however, was refuted by evidence that healthy cells exhibit the effects of radiation exposure when transferred to a medium in which irradiated cells were incubated (2) or when they merely reside in the same vicinity of previously irradiated cells (3), and that patients administered radiotherapy show abscopal effects, or the effects of radiotherapy even in organs distant from the site of radiation (4, 5, 6). (oneradionetwork.com)
- The researchers in fact conclude, "Our results support the hypothesis that proximity to an irradiated animal induces signaling changes in an unirradiated partner…the results could have implications for caregivers and hospital staff treating radiotherapy patients" (1, p. 72). (oneradionetwork.com)
- Presented are the results of morphological studies of radiation sickness, congenital malformations and malignant tumors which have developed in Chemobyl victims. (arctichealth.org)
- External radiation therapy has been an integral part of the armamentarium against primary or metastatic liver tumors. (hindawi.com)
- Currently, radiation may be directly targeted at liver tumors with the radioembolization technique. (hindawi.com)
- Beginning in early childhood (with a mean age of 8 years), numerous skin tumors develop over the UV-radiation exposed surfaces of the body and include actinic (solar) keratoses, keratoacanthomas, squamous cell carcinomas, basal cell carcinomas and melanomas. (renalandurologynews.com)
- conversely, PI3-kinase inhibition enhances the sensitivity of tumors to radiation. (nih.gov)
- One third of thyroid tumors occurring after radiation exposure are malignant, and most radiation-induced thyroid cancers are papillary thyroid carcinoma (PTC). (scielo.br)
- Mouse embryonic fibroblasts (MEFs) from these mice exhibit defective cell cycle checkpoints after radiation. (jax.org)
- Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance. (jax.org)
- Histological abnormalities of the reduced number of hair follicles, irregularly arranged and curved hair follicles, epidermal hyperplasia and disturbed differentiation of epidermis were observed in the PLCD1-deficient mice. (biomedcentral.com)
- MmRAD52 null mutant mice showed no abnormalities in viability, fertility, and the immune system. (asm.org)
- Ongoing work will map sensitivity after focal treatments and in mice with modified radiation response. (utoronto.ca)
- Preliminary study on the induction of sperm head abnormalities in mice, Mus musculus, exposed to radiofrequency radiations from global system for mobile communication base stations. (emf-portal.org)
- To study the effects of electromagnetic field exposure from GSM base stations on the induction of sperm head abnormalities in mice. (emf-portal.org)
- The exposure of male mice to radiofrequency irradiation from mobile phone GSM base stations at a workplace complex and in a residential environment caused 39.78 and 46.03% sperm head abnormalities , respectively, compared to 2.13% in control group . (emf-portal.org)
- In this work, we review relevant M. musculus inbred and F 1 hybrid animal models, as well as methods of induction of radiation-induced lung cancers. (scirp.org)
- By the early 1950s, however, follow-up studies of the A-bomb survivors in Japan and other exposed populations were showing that radiation-induced leukaemia and other cancers could arise even at low levels of exposure. (encyclopedia.com)
- Up to 10% of invasive cancers are related to radiation exposure, specifically ionizing radiation . (wikipedia.org)
-  Additionally, the vast majority of non-invasive cancers are non-melanoma skin cancers caused by ultraviolet radiation . (wikipedia.org)
- The UV part of solar radiation, in particular, is linked to disorders ranging from mild inflammatory effects of the skin to as serious as causing several different types of cancers. (redorbit.com)
- Skin cancers consisting of basal and squamous cell carcinomas are especially linked to the UVB part of solar radiation. (redorbit.com)
- Actinic keratosis is an erythematous scaly papule or plaque that develops on sun-damaged skin as a result of chronic exposure to ultraviolet radiation, typically in elderly patients with lighter skin types. (medscape.com)
- Ultraviolet (UV)-induced cataracts are becoming a major environmental health concern because of the possible decrease in the stratospheric ozone layer. (mdpi.com)
- The human eye and skin are the only tissues directly exposed to ultraviolet radiation (UV) and visible radiations. (mdpi.com)
- The full spectrum of UV radiation can be classified into three groups, based on wavelength, ultraviolet A (UVA) (400 - 315 nm), ultraviolet B (UVB) 315-280 nm, and ultraviolet C (UVC) (280-100 nm). (mdpi.com)
- Xeroderma pigmentosum (XP) is a rare genetic disease characterized by a spectrum of clinical phenotypes ranging from mild almost asymptomatic disease to severe sensitivity to ultraviolet radiation and neurological deficits. (renalandurologynews.com)
- Morphological abnormalities in amphibians may be attributed to contaminants, ultraviolet radiation and trematode parasites, or a synergistic effect between them. (fluoridealert.org)
- [ 2 ] These manifestations are due to a cellular hypersensitivity to ultraviolet (UV) radiation resulting from a defect in DNA repair. (medscape.com)
Morbidity and morta2
Sperm head abnormalities1
- Here, we report a comparative analysis of sperm head abnormalities among 11 species of passerine bird in Chernobyl, presumably resulting from chronic irradiation following the 1986 accident. (royalsocietypublishing.org)
- The Modified ONS Criteria for Radiation-Induced Acute Skin Toxicity will be used for classification of EASRs related to the skin. (clinicaltrials.gov)
- The primary outcome variable will be the occurrence (or not) of RT-induced EASR defined as a grade 4 or higher toxicity (based on the ONS criteria) during the 2 months of the follow-up period of the study. (clinicaltrials.gov)
- Studying the genetic pattern of patients before and after radiation therapy may help doctors prevent toxicity and plan the best treatment. (clinicaltrials.gov)
- One publication summarises the most important points about amiodarone-induced pulmonary toxicity (AIPT) as follows: "The most serious adverse reaction of amiodarone is pulmonary toxicity (AIPT). (wikipedia.org)
- Therapeutic approaches of melatonin in microwave radiations-induced oxidative stress-mediated toxicity on male fertility pattern of Wistar rats. (emf-portal.org)
- ABSTRACT: The effect of ionising radiation exposure on dementia is approached by applying the causation models of John Stuart Mill and of Sir Austin Bradford Hill to mechanism and epidemiological evidence. (scirp.org)
- History of agranulocytosis or severe (grade 3) drug-induced neutropenia or documented abnormalities in granulocyte number or function. (clinicaltrials.gov)
- Among these mutants, the Scrad51 , Scrad52 , and Scrad54 mutants display the most severe radiation sensitivity and defects in recombination. (asm.org)
- In general, the earlier the onset of symptoms and the greater the reported severity, the more likely the patient is to suffer from a severe course of radiation pneumonitis. (renalandurologynews.com)
- Long-term sequelae of chemotherapy and radiation are common, may be mild or severe, and may be asymptomatic for extended periods. (nap.edu)
- The nuclear accident at Chernobyl accounted for an acute radiation syndrome in 237 persons on the site. (arctichealth.org)
- Symptoms resulting from the intensive irradiation of a large segment of the gastrointestinal tract or portion of the bone marrow constitute a condition called radiation sickness, or acute radiation syndrome . (britannica.com)
- Avascular necrosis, acute osteomyelitis, radiation therapy, frostbite, electrical burns, Gaucher's or sickle cell disease (with or without infarction), may cause sufficient ischemia to be reflected on a bone scan as a photopenic lesion. (harvard.edu)
- The clinical and radiographic pattern mimics acute radiation pneumonitis and occurs in the prior radiation treatment field, despite the lack of recent radiation exposure. (renalandurologynews.com)
- The clinical pattern of acute radiation pneumonitis can vary widely among patients. (renalandurologynews.com)
- Like radiation, chemotherapy impacts brain development and results in late-appearing side effects that impair learning, memory and attention in many childhood acute lymphoblastic leukemia survivors. (utoronto.ca)
Doses of radiation3
- The risk for these problems is higher with higher doses of radiation, if you also got certain chemotherapies (bleomycin, busulfan, BCNU, and CCNU), or if you had part of the lung removed (lobectomy). (oncolink.org)
- The effects of LY294002, a biochemical inhibitor of PI3-kinase, on the response to radiation were examined in the PTEN mutant glioma cell line U251 MG. Low doses of LY294002 sensitized U251 MG to clinically relevant doses of radiation. (nih.gov)
- It appears that low doses of radiation are not harmful, since the body already has methods of defense. (topdocumentaryfilms.com)
- The study concludes that the RF-EMF may induce oxidative stress with an increased level of reactive oxygen species, which may lead to infertility. (stopumts.nl)
- Radio frequency electromagnetic radiation (RF-EMR) from GSM (0.9/1.8GHz) mobile phones induces oxidative stress and reduces sperm motility in rats. (emf-portal.org)
- Exposure of human or mouse skin to UVB radiation results in excessive generation of reactive oxygen species (ROS) that overwhelms the antioxidant defense system resulting in oxidative stress (2,5,6). (redorbit.com)
- Morphological abnormalities in natural populations of the common South American toad Rhinella arenarum inhabiting fluoride-rich environments. (fluoridealert.org)
- In the present study, morphological abnormalities in Rhinella arenarum adults from natural and artificial fluoride-rich environments were identified and evaluated. (fluoridealert.org)
- The MF-CN and HF-DP populations had morphological abnormality frequencies that exceeded the reference value (5%) reported in the literature. (fluoridealert.org)
- The results of this study indicate that there is an association between frequency of morphological abnormalities and high fluoride levels. (fluoridealert.org)
- Guembelitria irregularis Bloom at the K-T Boundary: Morphological Abnormalities Induced by Impact-related Extreme Environmental Stress? (springer.com)
- Fossil and Recent foraminiferal tests showing morphological abnormalities have long been reported from stressed environments. (springer.com)
- Accordingly, we speculate that the morphological abnormalities shown by the G. irregularis test across the K-T boundary are the result of the extremely stressful environmental conditions related to the complex interplay of different events (rapid and extreme climate fluctuactions, sea-level changes, intense volcanism, and impact events, which characterize the last hundreds of thousand of years of the Cretaceous and the beginning of the Danian. (springer.com)
- In particular, the post-K-T morphological abnormality of G. irregularis may be related to high stress conditions induced by the K-T impact. (springer.com)
- All patients were initially treated by modified radical mastectomy and then were managed by postoperative 3D Conformal Radiation Therapy (CRT) to the surgical bed with an additional 1-cm margin, delivered by 46-50 Gy (in 2 Gy daily fractions) over a 5-week course. (ac.ir)
- Six months after radiation therapy, all patients underwent cardiac SPECT for the evaluation of myocardial perfusion. (ac.ir)
- RATIONALE: Radiation therapy uses high-energy x rays to kill tumor cells. (clinicaltrials.gov)
- Radiation therapy may cause skin reactions when patients are exposed to high-energy x rays. (clinicaltrials.gov)
- They underwent myocardial perfusion scans (MPS) 3 years after the external beam radiation therapy at the bed of modified radical mastectomy. (ac.ir)
- Premature menopause can also be caused by medical interventions, such as bilateral oophorectomy , chemotherapy, or pelvic radiation therapy. (hon.ch)
- Some POF patients and some women following chemotherapy or pelvic radiation therapy experience temporary menopause. (hon.ch)
- However, this effective treatment comes with risks of its own, and the sheer number of patients that undergo radiation as a part of their therapy regimen is only increasing. (scirp.org)
- Radiation therapy was started, but because of progressive worsening of leg weakness and development of incontinence, a decompressive laminectomy was performed from T-11 to L-1. (harvard.edu)
- Olfactory detection thresholds for two odorants (amyl acetate and eugenol) were determined before the start of radiation therapy, within a week of termination of therapy, and 1, 3, and 6 months later. (biomedsearch.com)
- Radiation therapy. (clinicaltrials.gov)
- Radiation therapy (including electron beam irradiation) within 30 days prior to study entry. (clinicaltrials.gov)
- 6], and when radiation therapy is combined with chemotherapy, xerostomia may be exacerbated . (cancernetwork.com)
- Active surveillance, chemotherapy, retroperitoneal lymph node dissection, and radiation therapy are treatment options following orchiectomy. (aafp.org)
- Hypofractionated versus standard radiation therapy in combination with temozolomide for glioblastoma in the elderly: a meta-analysis. (mayo.edu)
- Radiation therapy is sometimes used to reduce pain from bone lesions. (omicsonline.org)
- Mediastinal radiation therapy is a commonly used treatment modality for malignancies involving the thorax. (acc.org)
- Interestingly, there appears to be a temporal delay between exposure to radiation therapy and development of symptomatic coronary obstruction. (acc.org)
- 9 The development of newer cardiac-shielding techniques, such as the multi-leaf collimator modification technique, has been successfully utilized to reduce exposure of coronaries to radiation therapy. (acc.org)
- I.e. radiation therapy to the chest, mediastinum, supraclavicula fossae or breast. (pneumotox.com)
- See also under other radiation therapy headings including SBRT. (pneumotox.com)
- Radiation therapy techniques have changed in the past decades. (pneumotox.com)
- More adverse effects were observed in the past following 67Co radiation therapy. (pneumotox.com)
- Organizing pneumonia can also be seen following radiation therapy. (renalandurologynews.com)
- With development of new radiation therapies (such as intensity-modulated radiation therapy or IMRT), patients can develop areas of inflammation in the periphery around the lesion, while sparing the area immediately around the radiated target. (renalandurologynews.com)
- Radiation therapy equipment developer RefleXion Medical has announced a clinical. (medworm.com)
- Radiation therapy is an integral part of treament for pediatric brain tumours and for high-risk leukemias, but is also associated with the generation of late-appearing side effects including cognitive, behavioural, and psychological impairments. (utoronto.ca)
- Chemotherapy, radiation therapy, and surgery may all cause late effects involving any organ or system of the body. (nap.edu)
- Some drugs may act as photosensitizers, increasing susceptibility to UV radiation, whereas others may increase the risk for squamous cell carcinoma regardless of exposure to UV radiation. (medscape.com)
Department of Radiation Oncology1
- Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-Sen University, Foshan, PR China. (amazonaws.com)
- This paper presents an overview of recent studies that address the role of microvascular injury, endothelial dysfunction, mast cells, and the renin angiotensin system in animal models of cardiac radiation injury. (hindawi.com)
- Most of our understanding of radiation effects on cardiac structures has come from these patient populations over the last 50 years. (acc.org)
- In this study, the radiobiological effects of ultrashort pulsed electron beam (UPEB) and X-ray radiation in human lung fibroblasts (MRC-5 cell line) exposed to doses of 0.1, 0.5, and 1 Gy are compared. (mdpi.com)
- Coggle, J.E. (1991) The Role of Animal Models in Radiation Lung Carcinogenesis. (scirp.org)
- 2006). Relation between radiation-induced whole lung functional loss and regional structural changes in partial irradiated rat lung . (rug.nl)
- Chemotherapy sensitizes the lung to the effects of radiation (PMID 12118569) and vice versa. (pneumotox.com)
- Radiation-induced lung injury can be separated into early and late effects of radiation. (renalandurologynews.com)
- Radiographic findings of lung injury are more much common than clinical symptoms of radiation-induced lung injury, and frequently occur in the area of the lung exposed to radiation. (renalandurologynews.com)
- Early lung injury tends to occur one to three months following radiation treatment, but can present as late as six months after radiation exposure. (renalandurologynews.com)
- Although organizing pneumonia has traditionally been included with the early manifestations of radiation lung injury, it can present later, and last longer, than traditional radiation pneumonitis, although the symptoms are similar. (renalandurologynews.com)
- A more rare form of radiation-induced lung injury, referred to as radiation recall, can be seen in patients who receive chemotherapy after undergoing previous thoracic radiation, often years prior to the development of pneumonitis. (renalandurologynews.com)
- Are you sure your patient has radiation-induced lung injury? (renalandurologynews.com)
- Radiation-induced lung injury almost always occurs inside the radiation ports. (renalandurologynews.com)
- Direct radiation injury will be limited to areas that have received radiation, although patients can develop a hypersensitivity-type reaction to the radiation and can develop inflammation in the contralateral lung. (renalandurologynews.com)
- 8 Whole breast radiation versus partial breast irradiation have been shown to result in significantly lower radiation doses to the left anterior descending artery (LAD) (mean 2.13 Gy ± 0.11 vs. 1.02 ± 0.17), with right-sided partial breast radiation resulting in minimal exposure. (acc.org)
- Irradiation Radiation is known to induce abnormalities in the nuclei of cells. (wikipedia.org)
- tumor-derived cell lines were frequently aneuploid and showed suppression of irradiation-induced p53 function. (pubmedcentralcanada.ca)
- We've written before about the dangers of plant irradiation, which also involves exposing foods to ionizing radiation. (anh-usa.org)
- The first relationship between radiation exposure and thyroid carcinoma was reported in 1950 after irradiation of the thymus soon after birth ( 1 ). (scielo.br)
- MYC also induced genomic destabilization in normal human fibroblasts, although these cells did not become tumorigenic. (pnas.org)
- A brief treatment of radiation injury follows. (britannica.com)
- Radiation injury occurs most readily in tissues and organs consisting of rapidly proliferating cells, as, for example, the skin, the lining of the gastrointestinal tract , and the bone marrow , where progenitor cells multiply continuously to replace the mature cells that are constantly being lost through normal aging. (britannica.com)
- Radiation injury also includes abnormalities produced in the embryo . (britannica.com)
- Studies using conventional magnetic resonance imaging sequences in animal radiation injury models found that focal and diffuse increased T2 signal underestimate the extent of histologic lesions and were not consistently seen ( 15 - 17 ). (aacrjournals.org)
- This could very well be the molecular mechanism for radiation-induced injury. (uvic.ca)
- Overview of nuclear radiation and its effects on the human body. (britannica.com)
- For further discussion, see radiation: Biologic effects of ionizing radiation . (britannica.com)
- The effects of radiation on these organs result primarily from the destruction of the progenitor cells and the consequent interference with the replacement of the mature cells, which is so vital to the maintenance of tissue structure and function. (britannica.com)
- Side effects from radiation treatment are directly related to the area of the body being treated. (oncolink.org)
- As radiation techniques have improved over the years, the risk of late effects has decreased. (oncolink.org)
- What Knowledge Is Considered Certain Regarding Human Somatic Effects of Ionizing Radiation? (ratical.org)
- Report prepared by the Advisory Committee on the Biological Effects of Ionizing Radiation. (ratical.org)
- This report was issued by the Committee on the Biological Effects of Ionizing Radiations, Division of Medical Sciences, National Research Council, National Academy of Sciences. (ratical.org)
- The effects of ionizing radiation on smell acuity were assessed in 12 patients in whom the olfactory mucosa was exposed to radiation in the course of treatment for nasopharyngeal carcinoma or pituitary adenoma. (biomedsearch.com)
- Most of the ways a pregnant woman may be exposed to radiation, such as from a diagnostic medical exam or an occupational exposure within regulatory limits, are not likely to cause health effects for a fetus. (cdc.gov)
- The National Council on Radiation Protection and Measurements external icon ' Report No. 174, "Preconception and Prenatal Radiation Exposure: Health Effects and Protective Guidance" [NCRP2013] provides detailed information for assessing fetal doses from internal uptakes. (cdc.gov)
- However, the dysgeusia associated with xerostomia is separate from the effects of radiation on the taste buds. (cancernetwork.com)
- 2006). Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field . (rug.nl)
- Tumorigenesis induced by MYC has been attributed to sustained effects on proliferation and differentiation. (pnas.org)
- The genetic effects due to radiation exposure appear in the next generation. (org.in)
- Early radiation effects manifest as radiation pneumonitis. (renalandurologynews.com)
- We are surrounded by several types of ionizing and non-ionizing radiations and both have recognized causative effects on spermatogenesis. (stopumts.nl)
- Since it is impossible to cover all types of radiation sources and their biological effects under a single title, this review is focusing on radiation deriving from cell phones, laptops, Wi-Fi and microwave ovens, as these are the most common sources of non-ionizing radiation , which may contribute to the cause of infertility by exploring the effect of exposure to radiofrequency radiation on the male fertility pattern. (stopumts.nl)
- Here we review the current evidence regarding the effects of electromagnetic radiation and heat in male fertility. (stopumts.nl)
- New research exposes how biophotons may be responsible for the transmission of adverse effects of radiation between individuals, and illuminates how the fabric of human consciousness may be based in light. (oneradionetwork.com)
- The quantification of these effects has provided the basis for radiation protection standards. (encyclopedia.com)
- Long-term effects of 900 MHz radiofrequency radiation emitted from mobile phone on testicular tissue and epididymal semen quality. (emf-portal.org)
- Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: role of ROS. (emf-portal.org)
- however, as this approach is unavoidable, it is suggested that other novel strategies be developed to reduce the effects of solar radiation to skin. (redorbit.com)
- One approach to reduce the harmful effects of solar radiation is through the use of phytochemicals, an approach that is popularly known as "Photochemoprotection. (redorbit.com)
- We describe here some of the most popular phytochemicals being studied that have the potential to reduce the harmful effects associated with solar UV radiation. (redorbit.com)
- As trends related to exposure of humans to solar UV radiation are expected to continue in the near future and pose a substantial human health risk, adverse effects associated with UVB exposure need to be appropriately addressed. (redorbit.com)
- The thyroid gland is highly sensitive to the carcinogenic effects of exposure to ionizing radiation during childhood and adolescence. (scielo.br)
- In addition to the defects in the repair genes, UV-B radiation also has immunosuppressive effects that may be involved in the pathogenesis of xeroderma pigmentosum. (medscape.com)
- First called mitogenic rays by the Russian scientist Alexander Gavrilovich Gurwitsch in the early twentieth century due to their propensity to induce cellular proliferation in nearby unexposed cells (19), biophotons "have been observed in bacteria, fungi , germinating seeds, plants, animal tissue cultures, and different parts of the human body, including the brain" (20). (oneradionetwork.com)
- When ionizing radiation passes through cellular tissue, it produces charged water molecules. (encyclopedia.com)
- Thyroid abnormalities after radiation exposure in infancy. (rochester.edu)
- Thyroid abnormalities, hypothyroidism where the thyroid does not pump out enough hormones so you get what is called Myxedema, very slow, you put on weight, your hair falls out, your mental capacities decline and your appetite goes away and your periods stop. (topdocumentaryfilms.com)
- Papillary carcinoma (PTC) is the most frequent form of thyroid carcinoma diagnosed after radiation exposure, with a higher prevalence of the solid subtype in young children with a short latency period and of the classical subtype in cases with a longer latency period after exposure. (scielo.br)
- Current research is directed on the mechanism of genetic alterations induced by radiation and on a molecular signature that can identify the origin of thyroid carcinoma after a known or suspected exposure to radiation. (scielo.br)
- The risk is significantly increased for radiation doses to the thyroid of 50-100 mGy, and for higher doses, the risk increases with increasing radiation doses to the thyroid gland ( 5 ). (scielo.br)
- congenital abnormalities of the coronary arteries, -vasospasm, -myocardial bridging, -coronary arteritis in association with systemic vasculitides, and -radiation-induced coronary disease. (brainscape.com)
Chemotherapy or radiation1
- According to CAMS, the term induced menopause is defined as the cessation of menstruation that follows either surgical removal of both ovaries (with or without hysterectomy) or iatrogenic ablation of ovarian function (e.g., by chemotherapy or radiation). (hon.ch)
- Since ionizing radiation is known to kill brain cells in laboratory culture and to affect hippocampal neurogenesis in animal experiments at modest doses, it is reasonable to assume that exposure to radiation must affect neurological integrity and hence dementia rates in those who are exposed. (scirp.org)
- Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality , speech changes, and abnormalities in eye movements. (wikipedia.org)
- Many patients may concurrently have neurological abnormalities (unrelated to sun exposure) as well as ophthalmological pathologies. (renalandurologynews.com)
- One large study of 830 XP patients found that 18% of them had neurological abnormalities with mental retardation present in 80% of those with neurological impairments. (renalandurologynews.com)
- To test the effect of gene-gene and gene-smoking interactions on RT-induced skin reactions. (clinicaltrials.gov)
- The brief surfeit of MYC activity was accompanied by evidence of genomic instability, including karyotypic abnormalities, gene amplification, and hypersensitivity to DNA-damaging agents. (pnas.org)
- There is also evidence that induced mutagenesis produces more unintended changes in gene expression than genetic engineering. (anh-usa.org)
- Thirty adult male SD rats were equally randomized into a normal, a radiated, and a Liuweidihuang group, the animals in the latter two groups exposed to electromagnetic radiation of 900 MHz cellphone frequency 4 hours a day for 18 days. (bvsalud.org)
- Male reproductive toxicants: Electromagnetic radiation and heat. (stopumts.nl)
- Human population in today's world lives surrounded by radiofrequency fields (RF) and electromagnetic radiation (EM) fields, transmitting almost all forms of electronic communication and data that humans produce every second. (stopumts.nl)
- Ultraviolet's position on the electromagnetic spectrum is on the boundary between ionizing and non-ionizing radiation. (wikipedia.org)
- The tissues of the embryo, like others composed of rapidly proliferating cells, are extremely sensitive to ionizing radiation. (britannica.com)
- The finding suggests that natural background external exposures to ionizing radiation are partly responsible for the development of dementia in human populations. (scirp.org)
- Sources of ionizing radiation may be natural (e.g., radioactive substances such as the element radium or the radioisotopes potassium-40 and carbon-14) or man-made (X-ray machines, nuclear reactors, particle accelerators, nuclear weapons, etc. (britannica.com)
- There is now considerable evidence that exposure to ionizing radiation can lead to the development of Alzheimers disease and to dementia . (scirp.org)
- There is no method to prevent or reverse these injuries when the heart is exposed to ionizing radiation. (hindawi.com)
- Agents such as ionizing radiation and certain chemicals also lead to the induction of DSBs in the genome. (asm.org)
- For example, in U2OS osteosarcoma cells, ionizing radiation-induced phosphorylation of p53 on serine-20 by CHK2 seems to mediate p53 stabilization and G 1 cell cycle arrest ( 10 ). (pubmedcentralcanada.ca)
- Exposure to ionizing radiation comes from a variety of sources. (encyclopedia.com)
- Radon is responsible for the worldwide majority of the mean public exposure to ionizing radiation . (wikipedia.org)
- Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation. (virtualtrials.com)
- For these experiments, two human Glioblastoma multiforme (GBM) cells (U373 and U87) were treated either with TTF alone or with TTF followed by ionizing radiation (IR). (virtualtrials.com)
- In women who experience surgically induced menopause, fertility ends immediately. (hon.ch)
- With other types of induced menopause, fertility may end immediately or over several months. (hon.ch)
- Kesari KK, Agarwal A, Henkel R. Radiation and male fertility. (stopumts.nl)
- The effect of mobile phone emitted radiation and heat on fertility is the subject of recent interest and investigations. (stopumts.nl)
- The change of the perfusion abnormalities by both visual assessment and quantifications (Autoquant) at the baseline and 3 years follow up time are compared between exposed and control patients. (ac.ir)
- Approximately half of all XP patients have ophthalmological abnormalities. (renalandurologynews.com)
- Patients with late fibrovascular sequelae of radiation or of combined radiation and surgery, with quantifiable symptomatology or disability, will be eligible for this trial. (knowcancer.com)
- high alert Patients who are pregnant or suspected of being pregnant, unless the potential benefits of a procedure using radiation far outweigh the risk of radiation exposure to the fetus and mother. (thefreedictionary.com)
- [ 10 ] Although typical symptoms of immune deficiency, such as multiple infections, are not usually observed in patients with xeroderma pigmentosum, several immunologic abnormalities have been described in the skin of patients with xeroderma pigmentosum. (medscape.com)
- Clinical studies of the skin of patients with xeroderma pigmentosum indicate prominent depletion of Langerhans cells induced by UV radiation. (medscape.com)
- Fluoride induced malformation in Rhinella arenarum adults. (fluoridealert.org)
- Most tragically, because our young people have received no official warning from U.S health agencies, they unknowingly micro-cook their sperm, ova and fetuses with a radiation known to be just as mutagenic and teratogenic as gamma wave radiation from nuclear fallout. (opednews.com)
- Tailed nuclei are signatures of radiation exposure in human tissue, microbiota, and aquatic invertebrates from the wake of recent nuclear disasters. (wikipedia.org)
- Of course, it was normal for people to fear radiation during the Cold War and now, as our fossil fuel reserves are close to depletion, nuclear energy is something desperately needed to compensate. (topdocumentaryfilms.com)
- How much of this documentary was actually about dispelling the exaggerated fear of radiation and how much was about promoting nuclear power is for you to decide. (topdocumentaryfilms.com)
- A link to BRCA1 is also supported by radiation-induced phosphorylation of serine-988 by CHK2, leading to the dispersal of BRCA1 nuclear dots ( 13 ). (pubmedcentralcanada.ca)
- radiation is also present in the environment as a result of nuclear weapons testing and as a consequence of discharges from nuclear sites and from nuclear accidents. (encyclopedia.com)
- Typical contributors to such risk include natural background radiation, medical procedures, occupational exposures, nuclear accidents, and many others. (wikipedia.org)
- Some occupations are exposed to radiation without being classed as nuclear energy workers. (wikipedia.org)
- Contrast-enhancing agents for demonstrating abnormalities of the blood-brain barrier may extend the diagnostic utility of proton nuclear magnetic resonance (NMR) imaging. (ajnr.org)
- Prevalence of incidental abnormalities on computed tomographic scans of the paranasal sinuses. (biomedsearch.com)
- Many kinds of radiation-induced abnormalities have been observed in experimentally irradiated rodents. (britannica.com)
Children and young adults1
- Anthracycline-induced cardiotoxicity in children and young adults. (springer.com)
- Characterization of radiation induced photopenic abnormalities on bone scans. (harvard.edu)
- Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression. (nih.gov)
Exposure to radiofrequency1
- 3 guidelines for safe human exposure to radiofrequency/microwave radiation. (scribd.com)
- Treatment of radiation-induced nodular goiters. (rochester.edu)
- Radiation treatment to the chest can affect the heart. (oncolink.org)
- When radiation treatment is planned, it is designed to avoid the heart as much as possible, but in many cases, it cannot be completely avoided. (oncolink.org)
- These symptoms typically develop between four and twelve weeks following radiation treatment. (renalandurologynews.com)
- Identification of radiation treatment impact on brain development. (utoronto.ca)
- Radiation increases the probability that dicentric chromosomes form after every mitotic event, creating physical bridges between them in anaphase and telophase. (wikipedia.org)