Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Malformations of organs or body parts during development in utero.
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
Congenital absence of or defects in structures of the eye; may also be hereditary.
Mapping of the KARYOTYPE of a cell.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.
Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
A characteristic symptom complex.
Congenital structural abnormalities of the skin.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The possession of a third chromosome of any one type in an otherwise diploid cell.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Congenital structural abnormalities and deformities of the musculoskeletal system.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Congenital absence of or defects in structures of the teeth.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
An infant during the first month after birth.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Elements of limited time intervals, contributing to particular results or situations.
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Learning algorithms which are a set of related supervised computer learning methods that analyze data and recognize patterns, and used for classification and regression analysis.
Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Actual loss of portion of a chromosome.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Mice bearing mutant genes which are phenotypically expressed in the animals.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An individual in which both alleles at a given locus are identical.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An individual having different alleles at one or more loci regarding a specific character.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Congenital structural abnormalities of the DIGESTIVE SYSTEM.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
A family of gram-negative bacteria usually found in soil or water and including many plant pathogens and a few animal pathogens.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
A variation from the normal set of chromosomes characteristic of a species.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The hollow, muscular organ that maintains the circulation of the blood.
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Disease having a short and relatively severe course.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Biochemical identification of mutational changes in a nucleotide sequence.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Recording of electric potentials in the retina after stimulation by light.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Congenital structural abnormalities of the respiratory system.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Congenital absence of or defects in structures of the jaw.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
Dominance of one cerebral hemisphere over the other in cerebral functions.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
NECROSIS of lung tissue that is cause by the lack of OXYGEN or blood supply. The most common cause of pulmonary infarction is a blood clot in the lung.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
The measurement of an organ in volume, mass, or heaviness.
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
Surgical instrument designed to extract the newborn by the head from the maternal passages without injury to it or the mother.
Any method used for determining the location of and relative distances between genes on a chromosome.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Refers to animals in the period of time just after birth.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Use of reflected ultrasound in the diagnosis of intracranial pathologic processes.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
Genes that influence the PHENOTYPE only in the homozygous state.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Diseases affecting the eye.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Congenital absence of or defects in structures of the mouth.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
Contractile activity of the MYOCARDIUM.
Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.
The observable response an animal makes to any situation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Mice which carry mutant genes for neurologic defects or abnormalities.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
Morphological and physiological development of EMBRYOS or FETUSES.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The degree of replication of the chromosome set in the karyotype.
The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Postmortem examination of the body.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Perinatal nephropathies. (1/804)

The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to limit the disposition of a fluid or solute load. Tubular reabsorption is also limited leading to the urinary loss of glucose, amino acids, bicarbonate and phosphate. Although the relatively low function of the immature kidney is a normal part of development, its capacity to respond under conditions of stress may be less adequate than in adults. An additional concern is that a variety of perinatal manipulations, such as the incidental or accidental ingestion of a chemical, may lead to varying degrees of altered morphogenesis or functional development of the kidney. Chemical induced renal anomalies may be of several types, but in typical teratology experiments hydronephrosis may be the most frequent observation. The functional consequences of these renal malformations may be lethal or inconsequential or while an animal may be able to survive and develop normally in the presence of a renal malformation, it is possible that a stressful situation would unmask a functional malformation which could compromise survival. Thus, some renal abnormalities may be subtle enough to go unnoticed without experimental tests. Without such tests it is impossible to evaluate the effect of functional alterations on successful adaptation.  (+info)

Developmental pathways: Sonic hedgehog-Patched-GLI. (2/804)

Developmental pathways are networks of genes that act coordinately to establish the body plan. Disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Environmental exposures can be associated with poor pregnancy outcomes, including dysmorphic offspring or children with a variety of diseases. An important goal of environmental science should be reduction of these poor outcomes. This will require an understanding of the genes affected by specific exposures and the consequence of alterations in these genes or their products, which in turn will require an understanding of the pathways critical in development. The ligand Sonic hedgehog, the receptors Patched and Smoothened, and the GLI family of transcription factors represent one such pathway. This pathway illustrates several operating principles important in the consideration of developmental consequences of environmental exposures to toxins.  (+info)

Young women taking isotretinoin still conceive. Role of physicians in preventing disaster. (3/804)

QUESTION: One of my adolescent patients was prescribed isotretinoin for severe acne by a dermatologist. I was shocked to discover she does not use any means of contraception. The dermatologist insists he told her about the need for contraception. How can we do better? ANSWER: Clearly this dermatologist, like many of his colleagues, does not comply with the Pregnancy Prevention Program. Until physicians become more aware of this program, babies will continue to be born with embryopathy due to isotretinoin.  (+info)

Embryonic and postnatal injections of bromodeoxyuridine produce age-dependent morphological and behavioral abnormalities. (4/804)

The mitotic marker 5-bromodeoxyuridine (BrdU) was injected twice daily (60 mg/kg) into pregnant hooded rats on one of embryonic days (E) 11, 12, 13, 15, 17, or 21, or into rat pups on postnatal day (P) 10. The principal findings were the following: (1) BrdU exposure on E11 produces profound effects on body morphology, and animals must be fed a special diet because of chronic tooth abnormalities; (2) BrdU exposure at E17 or earlier produces a change in coat spotting pattern, the precise pattern varying with age; (3) BrdU exposure on E15 or earlier produces a reduction in both brain and body weight; (4) BrdU exposure on E17 or earlier reduces cortical thickness; (5) BrdU exposure on E11-E13 and at P10 reduces cerebellar size relative to cerebral size; (6) spatial learning is significantly affected after injections of BrdU at E11-E17, but the largest effect is on E17; (7) the deficit in spatial learning may be related in part to a reduction in visual acuity; and (8) skilled forelimb ability is most disrupted after BrdU exposure at E15 but is also impaired after injections on E13 or earlier. BrdU thus has teratological effects on body, brain, and behavior that vary with the developmental age of the fetus or infant.  (+info)

Longitudinal limb deficiencies and the sclerotomes. An analysis of 378 dysmelic malformations induced by thalidomide. (5/804)

The pathogenesis of longitudinal reduction deformities of the limbs, or dysmelia, is still a matter of debate. Their morphological pattern was defined from a large collection of radiographs of children with dysmelia following the thalidomide disaster. We compared radiographs of 378 of these limbs with the sclerotomes which are areas of segmental sensory innervation of the limb skeleton defined by the radiation of referred pain. The pattern of dysmelia matched the sclerotomes closely in 279 limbs (73.5%). The principles of skeletal reduction in dysmelia are explained by the arrangement of the sclerotomes. The congruence between two separate and independent data sets shows that both patterns are expressions of the underlying segmental sensory innervation of the skeleton, and that the sensory nervous system is involved in the process of limb morphogenesis and teratogenesis.  (+info)

Pregnancy in patients after valve replacement. (6/804)

This report is based on information obtained from a questionnaire sent to major cardiac centres in the United Kingdom. This produced details of 39 pregnancies in 34 patients after valve replacement. The 39 pregnancies gave rise to 30 healthy babies. The small size of the series probably reflects both the increasing rarity of young women with rheumatic heart disease in this country and the cautious attitude of their cardiologists. This makes it likely that these women represented the best end of the spectrum of cardiac function after valve replacement. Twenty-four pregnancies in 20 women who were not given anticoagulants producted 23 healthy babies and 1 spontaneous abortion. This group comprised 6 patients with free aortic homografts, 1 patient with a fascia lata mitral valve, 1 with a Beall tricuspid prosthesis, 1 with a combined mitral homograft and Starr Edwards aortic prosthesis, and 1 with mitral and aortic frame-mounted fascia lata valves. There were no maternal deaths or thromboembolic complications in this group which included 5 patients who were in atrial fibrillation. Fifteen pregnancies in 14 women who received anticoagulants gave rise to 7 healthy babies. The fetal losses were one stillbirth, one intrauterine death at 34 weeks, and 3 spontaneous abortions; one surviving child has hydrocephalus as a result of blood clot and there were 2 maternal deaths. This group included 13 patients with Starr Edwards valves, 11 mitral and 2 aortic. A patient with a Hammersmith mitral valve was the only one to have been treated with heparin and her valve thrombosed. One patient with a mounted mitral homograft had a cerebral embolus. Nine of these patients were in atrial fibrillation. In 3 additional patients the valve replacement was carried out during pregnancy. Two of the patients survived operation. In one of these who was treated with warfarin the pregnancy well, but there is an increased fetal wastage in patients pregnancy gave rise to a congenitally malformed baby who died in the neonatal period. The baby born to the mother who did not receive anticoagulants has a hare-lip and talipes. Women with artificial valves can tolerate the haemodynamic load of pregnancy well, but there is an increased fetal wastage in patients taking oral anticoagulants. This is probably largely attributable to fetal haemorrhage but there is also a risk of malformation caused by a teratogenic effect of warfarin. Experience gained in non-pregnant patients suggests that withholding anticoagulatns in pregnant patients with prosthetic valves would usually be undersirable but warfarin should be avoided. The advantages of biological valves were apparent in this series.  (+info)

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. (7/804)

Previous experimental studies suggest that diabetic embryopathy is associated with an excess of radical oxygen species (ROS), as well as with a disturbance of prostaglandin (PG) metabolism. We aimed to investigate the relationship between these pathways and used hyperglycemia in vitro (embryo culture for 24-48 h) and maternal diabetes in vivo to affect embryonic development. Subsequently, we assessed lipid peroxidation and gene expression of cyclooxygenase (COX)-1 and -2 and measured the concentration of prostaglandin E2 (PGE2) in embryos and membranes. Both hyperglycemia in vitro and maternal diabetes in vivo caused embryonic dysmorphogenesis and increased embryonic levels of 8-epi-PGF2alpha, an indicator of lipid peroxidation. Addition of N-acetylcysteine (NAC) to the culture medium normalized the morphology and 8-epi-PGF2alpha concentration of the embryos exposed to high glucose. Neither hyperglycemia nor diabetes altered COX-1 expression, but embryonic COX-2 expression was diminished on gestational day 10. The PGE2 concentration of day 10 embryos and membranes was decreased after exposure to high glucose in vitro or diabetes in vivo. In vitro addition of NAC to high glucose cultures largely rectified morphology and restored PGE2 concentration, but without normalizing the COX-2 expression in embryos and membranes. Hyperglycemia/diabetes-induced downregulation of embryonic COX-2 gene expression may be a primary event in diabetic embryopathy, leading to lowered PGE2 levels and dysmorphogenesis. Antioxidant treatment does not prevent the decrease in COX-2 mRNA levels but restores PGE2 concentrations, suggesting that diabetes-induced oxidative stress aggravates the loss of COX-2 activity. This may explain in part the antiteratogenic effect of antioxidant treatment.  (+info)

Scanning electron microscopy of lithium-induced exogastrulae of Xenopus laevis. (8/804)

Lithium-induced exogastrulae are abnormal embryos which fail to complete gastrulation and do not form normal neural structures. Scanning electron microscopy has been used to compare the surface structure of the ectoderm cells of exogastrulae with that of the ectoderm cells of normal embryos and has shown that the appearance of ciliated cells is delayed in exogastrulae. In addition, the structure of endoderm cells, which remain exposed in these embryos, has been studied.  (+info)

See ACOGs Practice Advisory for guidance regarding reporting to the US Zika Pregnancy Registry.. The US Zika Pregnancy Registry has been established to track Zika virus infections that occur in pregnant women and the outcomes of those pregnancies. Obstetrician-gynecologists should report pregnant women with any laboratory evidence of Zika virus infection (positive or inconclusive test results) as well as any adverse outcomes to their state health department.. To better facilitate reporting, the CDC has provided a contact list of US Zika Pregnancy Registry contacts for each state (ACOG members only).. CDC Zika Pregnancy Hotline for Healthcare Providers ...
Xing, Jiangwa, Toh, Yichin, Xu, Shuoyu, Yu, Hanry (2015). A method for human teratogen detection by geometrically confined cell differentiation and migration. Scientific Reports 5. [email protected] Repository. https://doi.org/10.1038/ ...
The Registry is designed for open enrollment of all patients who meet the inclusion criteria. The function and activities of the Nuvigil/Provigil Pregnancy Registry will be publicized through direct mailings to obstetricians and pharmacists. Known prescribers identified from marketing sources will be targeted for Registry awareness. A toll-free phone line will be established for patient enrollment and a website containing information about the Registry for both physician and patient recruitment will be available. The Registry will be posted on the FDA website for pregnancy registries, with a direct link to a Nuvigil/Provigil Registry website. For ongoing awareness, information on the Registry will be included in the prescribing information and in the Medication Guides distributed by the pharmacist at the time of dispensing. In addition, patient support groups or condition-related sources of information may be targeted to raise patient awareness of the Registry ...
If you are interested in the MotHER Pregnancy Registry, call 1-800-690-6720 (Mon-Fri, 8:30 AM-6 PM EST). You can also contact us by email. Learn more.
PubMed journal article: Developmental toxicity study of pure trans-capsaicin in rats and rabbits. Download Prime PubMed App to iPhone, iPad, or Android
Caroline L. Tait National Network for Aboriginal Mental Health Research Alcohol-Related Birth Effects and Aboriginal Peoples: Prevention, Identification and Intervention Services This presentation examines
Not enough is known about the effects of medicines such as Herceptin®, PERJETA®, or KADCYLA® on pregnant women with breast cancer. Help answer these questions.
Samren, E.B.; Duijn, C.M. van; Koch, S. ; Hillesmaa, V.K.; Klepel, H.; Bardy, A.H.; Beck Mannagetta, G.; Deichi, A.W.; Gaily, E.; Granström, M.L.; Meinardi, H.; Grobbee, D.E.; Hofman, A.W.I.M.; Janz, D.; Lindhout, D. ...
The purpose of the Multi-National Gilenya Pregnancy Exposure Registry in Multiple Sclerosis (MS) is to continuously monitor, evaluate, and assess for major and minor teratogenic effects in the offspring of women exposed to Gilenya before (up to 8 weeks before last menstrual period) and during pregnancy in routine clinical practice. The overall aim is to collect and evaluate data on maternal, fetal, and infant outcomes and compare it with reference populations ...
Experience is limited with the use of Baraclude in pregnant women. Therefore, it should not be used during pregnancy unless it is clearly needed. If there is an urgent need to consider Baraclude during pregnancy, your doctor will discuss with you the benefits and risks of taking it. If you take Baraclude while you are pregnant, talk to your doctor about how you can take part in the Baraclude Pregnancy Registry. The purpose of the pregnancy registry is to collect information about the health of you and your baby ...
FDA thinks its important for the health of both a pregnant mother and her fetus to learn about a drug?s adverse effects: but is it?
Restricted scientific info are available in the Humira Pregnancy Registry. Excluding misplaced-tofollow- up, details within the registry reviews a level of five.six% for important birth defects with very first trimester use of adalimumab in Expecting Girls with rheumatoid arthritis (RA), as well as a fee of seven.8% and five.five% for key birth defects inside the disease-matched and non-diseased comparison teams [see Details]. Adalimumab is actively transferred over the placenta through the third trimester of pregnancy and should influence immune reaction inside the in-utero uncovered toddler [see Medical Things to consider ...
Are a woman who could become pregnant, or may be pregnant. HERCEPTIN may result in the death of an unborn baby or birth defects. Contraception should be used while receiving HERCEPTIN and after your last dose of HERCEPTIN. If you are exposed to HERCEPTIN during pregnancy or within 7 months of becoming pregnant, you are encouraged to enroll in the MotHER Pregnancy Registry by contacting 1-800-690-6720 or visiting http://www.motherpregnancyregistry.com/ and report HERCEPTIN exposure to Genentech at 1-888-835-2555. ...
List pre-pregnancy guidelines for transplant recipients and review the pregnancy outcomes from the Transplant Pregnancy Registry International ...
TY - JOUR. T1 - Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice. AU - Wang, Rui Sheng. AU - Ohtani, Katsumi. AU - Suda, Megumi. AU - Kitagawa, Kyoko. AU - Nakayama, Keiichi. AU - Kawamoto, Toshihiro. AU - Nakajima, Tamie. PY - 2007/8/1. Y1 - 2007/8/1. N2 - Ethylene glycol monoethyl ether (EGEE) can cause damage to testes and sperm, and its metabolites are believed to play an important role in its toxicity. Aldehyde dehydrogenase 2 (ALDH2) is involved in the metabolism of this chemical. To investigate whether and how the enzyme affects the toxicity of EGEE, we conducted experiments comparing Aldh2 knockout mice with wild-type mice. Administration of EGEE at 100 and 600 mg/kg/day for one week did not induce any significant change in the weight and body weight ratios of testes, prostate and epididymides in either Aldh2 knockout or wild-type mice. However, motion of sperm from the spermaduct, as analyzed with a Hamilton-Thorne Sperm analyzer, was slightly decreased in ...
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Alcohol-Related Birth Defects (ARBD)/Fetal alcohol syndrome is one of a spectrum of disorders under the umbrella term of fetal alcohol spectrum disord
The global diethylene glycol monoethyl ether market size was estimated at USD 374.9 million in 2018 and is expected to witness a CAGR of 5.3% from 2019 to 2025. The consumption of DEGEE is dominated by its application in floor polish and paints, coatings, and inks owing to its superior properties as a solvent
Other names: «beta»-Ethoxyethanol; Cellosolve; Emkanol; Ethyl cellosolve; Ethylene glycol ethyl ether; Ethylene glycol monoethyl ether; Glycol monoethyl ether; Oxitol; Plastiazan 60; Poly-Solv EE; 2-Ethoxyethanol; HOCH2CH2OC2H5; Cellosolve solvent; 2-Ethoxyethyl alcohol; Ethyl-2-hydroxyethyl ether; Dowanol EE; Ether monoethylique de lethylene-glycol; Ethyl glycol; Ethylethylene glycol; Etoksyetylowy alkohol; Glycol ethyl ether; Hydroxy ether; NCI-C54853; 2EE; EE solvent; EGEE; Ektasolve EE; Ethoxyethanol; Ethyl icinol; Glycol ether EE; Jeffersol EE; Bikanol E 1; NSC 8837; Solvid; 2-ethoxyethanol (cellosolve ...
(R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source of ketones, which may be utilized for energy. In a 28-day toxicity study, Crl:WI (Wistar) rats received diets containing, as 30% of the calories, ketone monoester (12 and 15 g/kg body weight/day for male and female rats, respectively). Control groups received either carbohydrate- or fat-based diets. Rats in the test group consumed less feed and gained less weight than control animals; similar findings have been documented in studies of ketogenic diets. Between-group differences were noted in selected hematology, coagulation, and serum chemistry parameters; however, values were within normal physiological ranges and/or were not accompanied by other changes indicative of toxicity. Upon gross and microscopic evaluation, there were no findings associated with the ketone monoester. In a developmental toxicity study, pregnant Crl:WI (Han) rats were administered 2g/kg body weight/day ketone monoester or water
Q00-Q99 - Congenital malformations of the circulatory system; Congenital malformations of the respiratory system; Cleft lip and cleft palate; Other congenital malformations of the digestive system; Congenital malformations of genital organs; Congenital malformations of the urinary system; Congenital malformations and deformations of the musculoskeletal system; Other congenital malformations; Chromosomal abnormalities, not elsewhere classified: Diseases and Medical Conditions (ICD-10) from Drugs-about.com
Mr. Speaker, I am pleased to rise to speak to the concurrence motion, the effect of which is to ask Health Canada to table with the House a comprehensive strategy to address fetal alcohol spectrum disorders. I very much support it and I will do as much as I can to ensure that other members in the House support the initiative. It is very important and it is time.. Let me talk very briefly about fetal alcohol spectrum disorders. Maternal consumption of alcohol during pregnancy is the leading known cause of mental retardation in Canada. As was indicated earlier, about one out of every 100 live births results in a birth defect. That means, and testimony has said, that up to 5,000 children each year will suffer from alcohol-related birth defects. It is very important that we understand the enormity of this and the attendant costs.. Here are a few of the secondary symptoms associated with FASD. Sixty per cent of these children will drop out of school or be suspended. Sixty per cent will get into ...
Data from the UK Epilepsy and Pregnancy Registry has shown that almost 96 per cent of babies born to women with epilepsy do not have a major congenital malformation (J Neurol Neurosurg Psychiatry 2006; 77: 193-8). The most effective drug should be chosen before conception and prescribed at its lowest dosage, ideally as monotherapy ...
Enrolling your patients in a pregnancy exposure registry can help improve safety information for medicines used during pregnancy and can be used to update drug labeling.
Isotretinoin (Accutane) is classified as a pregnancy category X drug, meaning it is a proven human teratogen or contains chemicals that are known to induce birth defects. The FDA has stringent guidelines regarding the use of this medication. ...
Abstract The antiepileptic drug Valproic acid (Val) is a known human teratogen. The risk is dose dependent and when the daily doses in pregnancy exceed 1400 mg up to 15% may be affected. The main clinical findings of the ...
In view of the great number of teratogenic factors known and the vast array of congenital defects, disorders and syndromes, it would probably be a waste of time to search for unifying mechanisms and principles in abnormal development. Instead, therefore, I shall describe a selection of teratogens and their consequences, and try to arrange them in a certain hierarchy based on a simplified model of how they act.. The assumption underlying the model (Figs. 1 and 2) is that the result of a teratogenic insult is determined by its site of action and the stage of development of the target organ. This is supposed to hold for all congenital defects, whether due to genes or caused by exogenous agents. In genetic defects the scheme indicates the site and stage of development at which the mutant gene is expressed; in nongenetic defects the site and stage refer to exposure to an exogenous teratogen.. ...
Degenhardt, K; Franz, J; and Yamamura, H, A model in comparative teratogenesis, dose response to 5-fluoro-2- -deoxycytidine (fcdr, ro 5-1090) in organogenesis of mice of strains c57bl/6jhanffm and c57bl/10jffm. (1968). Subject Strain Bibliography 1968. 1436 ...
Developmental toxicity The appropriate read-across candidate of delta-damascone, alpha-iso-methylionone (EC name:3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one) was tested in an oral (gavage) developmental toxicity study with rats (Charles River, 2005) One hundred pregnant Crl: CD®(SD) IGS BR VAF/Plus® rats were randomly assigned to four dosage groups, 25 rats per group. The test article, alpha-iso-methylionone, and/or the vehicle, corn oil, was administered to the rats orally (gavage) once daily on days 7 through 17 of presumed gestation (gestation days (GD) 7 through 17) at dosages of 0, 3, 10 and 30 mg/kg bw/day. The dosage volume was 10 mL/kg, based on individual body weights recorded daily before administration. Viabilities, clinical observations, body weights and feed consumption values were recorded. All rats were sacrificed on GD 21, Caesarean-sectioned and examined for the number and distribution of corpora lutea, implantation sites and uterine contents. A gross necropsy ...
Animal studies have revealed no evidence of teratogenicity or fertility impairment, but adverse effects including incomplete fetal skeletal ossification
There are currently no experimental data available to assess developmental toxicity / teratogenicity for calcium hydrogenorthophosphate. For the structural similar substance calcium dihydrogenorthophosphate monohydrate (CAS 10031 -30 -8) three studies are available which were done before guidelines were available (Morgareidge, 1974). These studies were conducted similar to OECD 414 in three different species - mice, rats and rabbits. Although the report is not as detailed as required according to todays standards these three studies are considered reliable in order to assess the developmental toxicity of calcium dihydrogenorthophosphate monohydrate. A reason for the dosage levels are not given which in fact are considered too low since no maternal toxicity was observed. But since the tests were conducted in three different species and in none of these studies developmental effects were observed these studies are considered as reliable on the basis of weight of evidence. Mice: Adult female albino ...
We are pioneering efforts to reduce birth defects through our innovative research endeavors. If you are new to this field, you may wonder what are birth defects? While still in the womb some babies have problems with how their organs and body parts form or, once formed, how they work. These are called birth defects.. There are more than 4,000 different kinds of birth defects, ranging from minor to major. Birth defects can occur at any stage of pregnancy. Some birth defects are inherited, some are caused by exposure to a harmful product in the environment (called a teratogen), and some are caused by a complex interaction of both genetic make-up and environment. But in about 50% of birth defects, the cause is unknown.. Heres what were doing to better understand the causes of birth defects, so we can better prevent and treat them.. ...
Animal Data The potential embryo-fetal toxicity of rolapitant was assessed in pregnant rats administered oral doses up to 22.5 mg/kg per day throughout the period of organogenesis. Rats administered doses of 13.5 or 22.5 mg/kg per day rolapitant exhibited evidence of maternal toxicity including decreased body weight gain and/or body weight loss and a concomitant decrease in food consumption during the first week of dosing. No adverse embryo-fetal developmental effects were observed at doses up to 22.5 mg/kg per day rolapitant (approximately 1.2 times the recommended human dose on a body surface area basis). In rabbits administered rolapitant throughout the period of organogenesis, oral doses up to 27 mg/kg per day (approximately 2.9 times the recommended human dose on a body surface area basis) were without effects on the developing fetus. The pre- and postnatal developmental effects of rolapitant were assessed in rats administered oral doses of 2.25, 9 or 22.5 mg/kg per day during the periods ...
Experimental Studies on Congenital Malformations (1959), by James G. Wilson The article Experimental Studies on Congenital Malformations was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson, studied embryos and birth defects
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system - Q07.9
Are a woman who could become pregnant, or may be pregnant. HERCEPTIN may result in the death of an unborn baby or birth defects. Contraception should be used while receiving HERCEPTIN and after your last dose of HERCEPTIN. If you are exposed to HERCEPTIN during pregnancy or within 7 months of becoming pregnant, you are encouraged to enroll in the MotHER Pregnancy Registry by contacting 1-800-690-6720 or visiting http://www.motherpregnancyregistry.com/ and report HERCEPTIN exposure to Genentech at 1-888-835-2555. ...
CDC Split Type: (blank) waes0705usa03252. Write-up:Information has been received from a physicians physicians assistant through the Merck Pregnancy registry concerning a 15 year old female patient with asthma who on 16-JAN-2007, was vaccinated IM with a second dose of Gardasil (Lot# 655617/1447F). Concomitant therapy therapy included albuterol MDI. After the second dose, it was discovered that she was pregnant. No adverse events were noted. On 24-MAY-2007, the patient elected to terminate the pregnancy. The patient was 21 weeks from last menstrual period. On 20-MAY-2007 and 22-MAY-2007, an ultrasound was performed and the results were unknown. At the time of this report, the patients outcome was unknown. It was also reported on 16-NOV-2006, the patient was vaccinated with a first dose of Gardasil (Lot# 653736/0868F). No product quality complaint was involved. Upon internal review, elective termination was considered to be an other important medical event. Additional information is not ...
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Piperazină-agent teratogen: Citiți mai multe despre Simptomele, Diagnosticul, Tratamentul, Complicațiile, Cauzele și Prognoza.
Despite study limitations, results suggest that duloxetine does not appear to increase the rate of major malformations above baseline.
Metamorphic Congenital Malformation lyrics by Cephalotripsy: Scourging paths of the impermissible / Descending upon dwellings of those
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This page was last edited 05:31, 3 May 2008 by [email protected] Based on work by wikidoc anonymous users Lisatwo and Arcadian ...
[150 Pages Report] Check for Discount on 2016 Propylene Glycol MonoEthyl Ether (CAS 52125-53-8) Industry Market Report report by Prof Research. The Global and Chinese Propylene Glycol MonoEthyl Ether Industry, 2011-...
QY Research Reports described a depth and professional market study and forecast trends on Global and China Dipropylene Glycol Monoethyl Ether (DPE) Industry Research Report 2013. This report also includes more info about basic overview of the industry including definitions, applications and industry china structure.. ...
TY - JOUR. T1 - Bayesian semiparametric analysis of developmental toxicology data. AU - Dominici, Francesca. AU - Parmigiani, Giovanni. PY - 2001. Y1 - 2001. N2 - Modeling of developmental toxicity studies often requires simple parametric analyses of the dose-response relationship between exposure and probability of a birth defect but poses challenges because of nonstandard distributions of birth defects for a fixed level of exposure. This article is motivated by two such experiments in which the distribution of the outcome variable is challenging to both the standard logistic model with binomial response and its parametric multistage elaborations. We approach our analysis using a Bayesian semiparametric model that we tailored specifically to developmental toxicology studies. It combines parametric dose-response relationships with a flexible nonparametric specification of the distribution of the response, obtained via a product of Dirichlet process mixtures approach (PDPM). Our formulation ...
Values obtained for specific surface area depend on the method of measurement. In adsorption based methods, the size of the adsorbate molecule (the probe molecule), the exposed crystallographic planes at the surface and measurement temperature all affect the obtained specific surface area.[4] For this reason, in addition to the most commonly used Brunauer-Emmett-Teller (N2-BET) adsorption method, several techniques have been developed to measure the specific surface area of particulate materials at ambient temperatures and at controllable scales, including methylene blue (MB) staining, ethylene glycol monoethyl ether (EGME) adsorption,[5] electrokinetic analysis of complex-ion adsorption[4] and a Protein Retention (PR) method.[6]. ...
This page includes the following topics and synonyms: Fetal Alcohol Syndrome, Fetal Alcohol Effect, Fetal Alcohol Spectrum Disorders, Partial Fetal Alcohol Syndrome, Alcohol-Related Neurodevelopmental Disorder, Alcohol-Related Birth Defect.
This page includes the following topics and synonyms: Fetal Alcohol Syndrome, Fetal Alcohol Effect, Fetal Alcohol Spectrum Disorders, Partial Fetal Alcohol Syndrome, Alcohol-Related Neurodevelopmental Disorder, Alcohol-Related Birth Defect.
The foetal outcomes of 2,635 pregnancies recorded in the Australian Pregnancy Register were studied. In at least the initial 4 months of 515 pregnancies, there had been no intrauterine exposure to antiepileptic drugs, though the women involved in 264 of these pregnancies took antiepileptic drugs in later pregnancies. Compared with these 515 drug-unexposed pregnancies, foetal malformations risks were increased more than five-fold in association with valproate monotherapy, and more than doubled in association with carbamazepine monotherapy (p , 0.05). There were no statistically significant increases in malformation rates associated with other more commonly used antiepileptic drugs, while the malformation risk in relation to levetiracetam exposure was lower than that in the drug-unexposed pregnancies. The published literature has rather consistently shown raised malformation rates associated with carbamazepine monotherapy, though only once was it statistically significant. There now appears to be ...
The projects underway include studies of the fetal effects of anticonvulsant drugs taken by pregnant women. One major activity is the North American AED (antiepileptic drug) Pregnancy Registry, which was established in 1997. Over 8,000 women in the United States and Canada have enrolled while pregnant. The apparent safety of over 30 different anticonvulsant drugs is being evaluated. Several significant new findings have been reported.. Another major project is the study of the causes of malformations identified in newborn infants at Brigham and Womens Hospital. The Active Malformations Surveillance Program began in 1972 and has identified over 250,000 affected newborn infants. The apparent causes have been analyzed and tabulated and show a high degree of heterogeneity. This project is supported by funds provided by the National Birth Defects Prevention Study, which is coordinated by the Birth Defects Center at the Centers for Disease Control.. ...
Amelia of Upper Limb (Limb Reduction Defect): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Muscle Beach looks like an old film set or something, a courtyard with empty garages and buildings encircling it. The Beach is set back in one of these. We rolled up right when VBS were getting there and some noise dude was setting up. We took seats on some old couches and I broke open the flask of Knobb Creek I brought along (heard Muscle Beach doesnt have a bathroom, so I didnt wanna fill up). The vibe definitely seemed more Jeff the Pigeon than Jans Room. First noiser dude (not sure who it was) had a chaotic rumble going on, but when he started vocalizing, it interrupted the black cloud I was digging. After he finished up, wound up blabbing with Dan from VBS about Lux-era Temple of Bon Matin and such, everyone was buzzing and babbling, thanks for the new CD, dude. After I mooched a Schaeffers from him, VBSs other guitar player put a few drops of some w33dy-grain alcohol concoction in it. I was kinda like, yeah right, but why not ...
4.5 Interaction with other medicinal products and other forms of interaction Laxatives. There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetam. Therefore, macrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.. 4.6 Fertility, pregnancy and lactation Pregnancy. Postmarketing data from several prospective pregnancy registries have documented outcomes in over 1000 women exposed to levetiracetam monotherapy during the first trimester of pregnancy. Overall, these data do not suggest a substantial increase in the risk for major congenital malformations, although a teratogenic risk cannot be completely excluded. Therapy with multiple antiepileptic medicinal products is associated with a higher risk of congenital malformations than monotherapy and therefore monotherapy should be considered. Studies in animals have shown reproductive toxicity (see ...
The French Perinatal Cohort reported an association of head and neck birth defects with first-trimester exposure to didanosine (0.5%, AOR = 3.4 (95% CI, 1.1-10.4), P = 0.04).4 Though the PHACS/SMARTT cohort found no association between any individual NRTIs and birth defects, after adjusting for birth cohort and other factors, didanosine in combination with stavudine was associated with an overall increase in congenital abnormalities;5 it should be noted that the combination of didanosine and stavudine should no longer be used in pregnant women with HIV (or anyone with HIV) because of higher risk of toxicity. Among 897 births to women with HIV in a Spanish cohort, there was no significant difference in the rate of birth defects between first-trimester compared to the second- and third-trimester exposure (OR 0.61, 95% CI, 0.16-2.27).6 In the Antiretroviral Pregnancy Registry, sufficient numbers of first-trimester exposures to didanosine in humans have been monitored to be able to detect at least a ...
Special thanks to Elise Lewis for taking time out of her busy schedule at SOT to make sure things were running smoothly in the booth throughout the event. In addition, Alan Hoberman, Vice President, shared Teratology Society information and co-presented the Edward W. Carney Trainee Award with Chris Bowman, RDTSS President, at the SOT Reproductive and Developmental Toxicology Specialty Section Reception on Tuesday evening.. Thank you all for serving as ambassadors of the Teratology Society this week in Baltimore! ...
TY - JOUR. T1 - Perspectives of primary care clinicians on teratogenic risk counseling. AU - Schwarz, Eleanor. AU - Santucci, Aimee. AU - Borrero, Sonya. AU - Akers, Aletha Y.. AU - Nikolajski, Cara. AU - Gold, Melanie A.. PY - 2009/10/1. Y1 - 2009/10/1. N2 - BACKGROUND: Women of childbearing age are commonly prescribed medications by primary care providers (PCPs) that may cause birth defects if used during pregnancy. METHODS: To identify what PCPs perceive as barriers to and potential facilitators of providing counseling to women of childbearing age when teratogenic medications are prescribed, we conducted eight focus groups with 48 PCPs recruited from four clinical settings in Pittsburgh, Pennsylvania. We explored PCPs experiences counseling women about teratogenic medications. Each focus group was audio-recorded, transcribed, and coded using a grounded theory approach by three independent coders. RESULTS: PCPs feel responsible for counseling women when they prescribe medications that may ...
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A gift to NOFAS will help raise awareness about the risk of alcohol use during pregnancy and prevent alcohol-related birth defects, and will support individuals and families living with FASD. You will be helping to build a network of resources and improving outcomes for both children and adults ...
In the rat embryo/fetal developmental toxicity study, pregnant rats received daily oral doses of mirabegron at 0, 10, 30, 100, or 300 mg/kg from implantation to closure of the fetal hard palate (7th to 17th day of gestation). Maternal systemic exposures were approximately 0, 1, 6, 22, or 96 times greater than exposures in women treated at the MRHD of 50 mg based on AUC. No embryo/fetal toxicities were observed in rats exposed up to 6 times the human systemic exposure at the MRHD of 50 mg. At systemic exposures equal to or greater than 22 times the human systemic exposure at the MRHD, delayed ossification and wavy ribs were observed in fetuses at an increased incidence. These findings were reversible.. In the rabbit embryo/fetal developmental toxicity study, pregnant rabbits received daily oral doses of mirabegron at 0, 3, 10, or 30 mg/kg from implantation to closure of the fetal hard palate (6th to 20th day of gestation). Maternal systemic exposures were 0, 1, 14, or 36 times that in women ...
Rogers JM. Rogers J.M. Rogers, John M.Developmental Toxicology. In: Klaassen CD, Watkins III JB. Klaassen C.D., & Watkins III J.B.(Eds.),Eds. Curtis D. Klaassen, and John B. Watkins III.eds. Casarett & Doulls Essentials of Toxicology, 3e. McGraw-Hill; Accessed October 24, 2020. https://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=1541§ionid=92520192 ...
Running Head: TERATOGENS DURING PREGNANCY Teratogens During Pregnancy Nicole Carter PSY 2103 - Human Development Mary Wilson November 9, 2010 | Teratogens
After adjusting for potential confounders, clindamycin exposure was associated with an increased risk of MCMs (aOR 1.34, 95%CI, 1.02-1.77, 60 exposed cases), musculoskeletal system malformations (aOR 1.67, 95%CI, 1.12-2.48, 29 exposed cases) and ventricular/atrial septal defect (aOR 1.81, 95%CI, 1.04-3.16, 13 exposed cases).. Doxycycline exposure increased the risk of circulatory system malformation, cardiac malformations and ventricular/atrial septal defect (aOR 2.38, 95%CI ,1.21-4.67, 9 exposed cases; aOR 2.46, 95%CI, 1.21-4.99, 8 exposed cases; aOR 3.19, 95%CI, 1.57-6.48, 8 exposed cases, respectively). Additional associations were seen with quinolone (1 defect), moxifloxacin (1 defect), ofloxacin (1 defect), macrolide (1 defect), erythromycin (1 defect) and phenoxymethylpenicillin (1 defect). No link was observed with amoxicillin, cephalosporins and nitrofurantoin. Similar results were found when penicillins were used as the comparator group.. Conclusions. ...
Enrolment should take place as early in the pregnancy as possible and prior to any knowledge of the pregnancy outcome. Healthcare providers and pregnant women are encouraged to notify GSK Safety Department of any pregnancies where exposure to mepolizumab has occurred and the pregnancy outcome is already known. An Eligible pregnant woman may self-enrol at any time during their pregnancy or, with their consent, their HCP may enrol them on their behalf. Contact Information: The study is conducted on behalf of GSK by:. The Organization of Teratology Information Specialists (OTIS) Research Center. University of California. La Jolla. San Diego. California. USA. Telephone: 877.311.8972. Email: [email protected] For more information, visit the MotherToBaby Website: http://www.mothertobaby.org/refer. Enrolment. Target Enrolment: ...
All pregnant women ages 18-45 are eligible to enroll in the registry. We are currently seeking both controls and those being treated with atypical antipsychotics and/ or antidepressants.. This study will involve 3 brief phone interviews over an 8-month period. The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications that may be taken by women during pregnancy to treat a wide range of mood, anxiety, or psychiatric disorders. The primary goal of this Registry is to determine the frequency of major malformations, such as heart defects, cleft lip, or neural tube defects, in infants exposed to atypical antipsychotics and antidepressants during pregnancy. For more information, please call 1-866-961-2388 or e-mail [email protected] Help make the future better for many other women like you ...
The use of behavioral changes as an indicator of teratogenic potential is evaluated. Testing procedures involving central nervous system activity or task specific responses are discussed along the effects of drug metabolism on behavioral response. Preliminary results of a behavioral teratology study of methylene- chloride (75092) in Long-Evans-rats are included. The author concludes that behaviora
Many herbs used for these purposes are believed to be teratogens, substances that cause the development of abnormal structures in the embryo. Usually teratogens in a womans system during the first two weeks of pregnancy (from conception) will cause the pregnancy to terminate. To help you understand why this is, Ive added a section on the day to day development of the fertilized egg with pictures ...
Two-dimensional echocardiography showed no cardiac abnormality. An ultrasound scan of the abdomen was also normal. A radiograph of the dorsolumbar spine revealed an unfused spinous process of the L5 vertebra. A radiograph of the skull was normal. In view of the history of maternal intake of VPA during pregnancy and the typical dysmorphic features, a diagnosis of FVS was made.. Discussion. None of the currently available AEDs are completely safe during pregnancy, but VPA appears to be the most teratogenic. In approximately 1 in 250 pregnancies the fetus is known to be exposed to AEDs, and a significant proportion ofthese are exposed to VPA.[2] The overall risk of major congenital malformation (MCM) in patients receiving AEDs during pregnancy is 4.2%. The MCM rate is higher for polytherapy than for monotherapy, and polytherapy regimens containing valproate result in significantly more MCMs than those not containing valproate. For monotherapy exposure, valproate has a higher MCM rate than any other ...
Congenital Malformations of the Head and Neck offers a unique conceptual and visual approach to children with congenital malformations of the head and neck Developed by renowned leaders in the field, this title is richly illustrated with a wealth of patient photos, radiology and endoscopic images of malformations Starting with the genetics of common congenital syndromes, Congenital Malformations of the Head and Neck goes on to comprehensively cover malformations of the ear, nose, nasopharynx, oral cavity, oropharynx, cleft lip and palate, larynx, trachea, and neck �Easy-to-read and an indispensable reference and teaching resource, this title will serve as an invaluable reference for clinicians, neurologists, pediatricians, otolaryngologists and head and neck surgeons It should also be of great interest to fellows and residents � ...
There are things in this world which you should avoid if you are planning a pregnancy. A teratogen is a substance or condition which can cause a birth defect. There are relatively few, known teratogens. Not all birth defects are…. Read more →. ...
Abstract: n 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:Table Normal; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Times New Roman,serif;} Background: Alprazolam belongs to benzodiazepine family and is increasingly used these days by pregnant women. It should be noticed that alprazolam exposure during pregnancy may have teratogenic effects on the fetus. Till now, limited studies have been conducted on the teratogenic effect of alprazolam. In this study, teratogenicity of alprazolam intake during pregnancy and its effects on fetus development was investigated. nnMethods: About 20 virgin rats of known age and weight were selected. After being pregnant, they were divided ...
It is wise to avoid most herbs and medications completely in the first trimester of pregnancy, if possible. It is during the first trimester that teratogenic effects - the negative result of consuming a harmful substance that affects the baby - are most common. Some teratogenic effects are fetal alcohol syndrome, birth defects, and mental retardation. It is important to seek guidance from a qualified herbalist or holistic provider before taking herbs during pregnancy to determine the safest herb and dosage for mom and baby. In general, you should avoid medicinal amounts of herbs during pregnancy, without first consulting with an herbalist or holistic provider trained in their use. It is also important to avoid large amounts of alcohol tinctures, and to make sure that any herbs you use are high quality and free of adulteration or contamination.. ...
In a key pre-natal developmental toxicity study, the test material (Rosin, CAS# 8050-09-7) was administered by continuous dietary admixture to three groups each composed of twenty-four time mated Sprague-Dawley Crl:CD®(SD) IGS BR strain rats, between gestation days 3 and 19 (inclusive) at dietary concentrations of 2500, 5000, or 7500 ppm (equivalent to mean achieved dosages of 199.3, 387.2 or 561.1 mg/kg bw/day respectively). A further group of twenty-four time mated females was fed basal laboratory diet to serve as a control. Clinical signs, body weight change, food and water consumptions were monitored during the study. All females were terminated on gestation day 20 and subjected to gross necropsy including examination of the uterine contents. The number of corpora lutea, number, position and type of implantation, placental weights, foetal weight, sex and external and internal macroscopic appearance were recorded. Half of the pups from each litter were examined for detailed skeletal ...
Ledipasvir: Ledipasvir was administered orally to pregnant rats (approximately 100 mg/kg/day) and rabbits (up to 180 mg/kg/day) on gestation days 6 to 18 and 7 to 20, respectively, and also to rats (oral doses up to 100 mg/kg/day) on gestation day 6 to lactation/post-partum day 20.. No substantial results on embryo-fetal (rats and bunnies) or pre/postnatal (rats) development were observed at the greatest dosages checked. Systemic exposures (AUC) to ledipasvir were ≥ 4 (rats) and 2 (bunnies) times the direct exposure in human beings at the RHD.. Sofosbuvir: Sofosbuvir was administered orally to pregnant rats (approximately 500 mg/kg/day) and rabbits (approximately 300 mg/kg/day) on pregnancy days 6 to 18 and 6 to 19, respectively, as well as to rats (oral doses up to 500 mg/kg/day) on gestation day 6 to lactation/post-partum day 20.. No significant results on embryo-fetal (rats and bunnies) or pre/postnatal (rats) development were observed at the highest dosages checked. Systemic exposures ...
Animal studies can, but do not always, predict whether a drug will be teratogenic in humans. The main role of animal studies is to help researchers understand the mechanisms of teratogenicity. Unfortunately, animal studies were poor predictors in the case of thalidomide; the drug was tested on rats and mice, but did not originally produce birth defects.1 On the other hand, some drugs have been found teratogenic in animals and not in humans.2,3 Today, when new drugs are screened for teratogenicity, three different animal models are required for testing. Quite frequently, when certain drugs are tested on different animal species, birth defects occur, as happened in the DM study.4 Interspecies differences regarding the teratogenicity of drugs can result from differing pharmacokinetic processes that determine the crucial concentration-time relationships in an embryo. Protein binding in the mother is also an important determinant of placental transfer because only free concentrates in maternal plasma ...
Assessment of the developmental toxicity and placental transfer of 1,2-dichloroethane in rats.: This study evaluates the developmental toxicity and placental tr
A simple and informative look at teratogens that may cause birth defects. CBNS 169. **EDIT: NEW VERSION, NOW WITH LEGAL AUDIO** old, original version, muted version available on my videos.. ...
These data from the Strasbourg Prospective Study of Congenital Malformations are reported in Congenital Malformations Worldwide: A Report from the International Clearinghouse for Birth Defects Monitoring Systems.. ...
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Teratogen is a simple roguelike for testing the Go programming languages suitability for game development. Currently only works on Linux. Note from author: As of 2010-11, the project is on permanent hiatus. Google dropped the exp/iterable module from Go, which the Teratogen code uses extensively for its internal logic. Code will need either a rewrite or copying the old exp/iterable code into the internal source tree to be compilable with a current version .of Go. The current Go language, still without generics, is a bit too hostile to abstraction in algorithm code for me to bother. I might get back to it when they get a generics implementation out. ...
A few months losartan and fetal toxicity Apple Watch features include a heart rate monitor, gyro, NFC, GPS, Handoff and the proprietary OS that is supposed to rival Android Wear
The anticoagulant ( blood thinner ) Coumadin is a known teratogen, an agent that can disturb the development of the embryo and fetus and lead to birth defects.. Coumadin taken by a woman during pregnancy can cause bleeding into the baby s brain…
"Severe and Unrecognized Dental Abnormalities After Drug-Induced Epidermal Necrolysis". Arch. Dermatol. 145 (11): 1332-1333. doi ... Common environmental factors include infection, trauma and drugs which predispose to the condition. In hereditary cases, ... A relationship was also postulated between abnormalities of the brainstem and the presence of agenesis.[13] ... "Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study" ...
said there was "... increasing evidence from animal studies showing that cannabinoid drugs ... induce enduring neurobehavioral ... but abnormalities in the endocannabinoid system during the phase of placental development are also linked with problems in ... Drugs in pregnancy Fonseca BM, Correia-da-Silva G, Almada M, Costa MA, Teixeira NA (2013). "The Endocannabinoid System in the ... Hoell I, Havemann-Reinecke U (October 2011). "[Pregnant opioid addicted patients and additional drug intake. Part I. Toxic ...
Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia (inducibility of VT/VF[3 ... The doctor will pace each chamber of the heart one by one, looking for any abnormalities. Then the electrophysiologist tries to ... If the arrhythmia is reproduced by the drugs (inducible), the electrophysiologist will search out the source of the abnormal ...
The incidence of drug-induced parkinsonism increases with age. Drug-induced parkinsonism tends to remain at its presenting ... Chronic manganese (Mn) exposure has been shown to produce a parkinsonism-like illness characterized by movement abnormalities.[ ... Drug-induced[edit]. About 7% of people with parkinsonism developed symptoms as a result of side effects of medications, mainly ... "Information Sheet: Drug-induced Parkinsonism" (PDF). Parkinson's Disease and Society. Archived from the original (PDF) on 2013- ...
Mistoprostol is a drug treatment for peptic ulcers that can also cause abortion or induce labor. The use of this drug (inserted ... Uterine hyperstimulation may result in fetal heart rate abnormalities, uterine rupture, or placental abruption. It is usually ... Briggs GG, Wan SR (June 2006). "Drug therapy during labor and delivery, part 2". Am J Health Syst Pharm. 63 (12): 1131-9. doi: ... Briggs GG, Wan SR (June 2006). "Drug therapy during labor and delivery, part 2". Am J Health Syst Pharm. 63 (12): 1131-9. doi: ...
Drug-induced nail changes are caused by drug usage which may result in various abnormalities. In approximately half of ... or side effects of drugs. Onychomadesis is the separation and falling off of a nail from the nail bed. Common causes include ... Nail Abnormalities: Clues to Systemic Disease Links to pictures of Toenail Diseases (Wiggins MD). ... systemic upsets or adverse reaction to drugs. Onychorrhexis also known as brittle nails, is brittleness with breakage of ...
... can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. Although ... Chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues. ... a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, ...
Coadministration of moxifloxacin with other drugs that also prolong the QT interval or induce bradycardia (e.g., beta-blockers ... including those with conduction abnormalities. The safety of moxifloxacin in children under age 18 has not been established. ... "Center for drug evaluation and research Application number 21-598" (PDF). Food and Drug Administration (FDA). 15 April 2005. ... "Moxifloxacin". Drug Information Portal. U.S. National Library of Medicine. "Moxifloxacin hydrochloride". Drug Information ...
Drug-inducedEdit. Vancomycin can induce a linear IgA bullous dermatosis in some patients. ... Some theories suggest an abnormality of the immune system results in these deposits.[22] ... Polysaccharide antigens tend to induce more IgA2 than protein antigens.[10] ...
Toxic and drugs Alcoholic liver disease Rarely drug induced liver disease from methotrexate, amiodarone, nitrofurantoin and ... myelofibrosis and metabolic abnormalities such as Gaucher's disease and glycogen storage diseases. Portal hypertension Ascites ... alcohol and some drugs) Cerebellar signs (alcohol and Wilson's disease) Liver enlargement (alcohol, NAFLD, haemochromatosis) ... bile acids or other drugs. Supportive therapy for complications of cirrhosis include diuretics, albumin, vitamin K, blood ...
Research on the effect of the psychedelic drug psilocybin shows that the altered state of consciousness induced by this drug ... Therefore, functional abnormalities of the PCC might be an accumulation of remote and widespread damage in the brain.[4] ... Structural and functional abnormalities in the PCC result in a range of neurological and psychiatric disorders. The PCC likely ... Further abnormalities in the PCC, abnormal NMDA, cannabinoid, and GABAergic receptor binding have been found with post-mortem ...
... exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and ... and cellular adaptations that occur in specific brain regions to mediate addiction-associated behavioral abnormalities. These ... DESPITE THE IMPORTANCE OF NUMEROUS PSYCHOSOCIAL FACTORS, AT ITS CORE, DRUG ADDICTION INVOLVES A BIOLOGICAL PROCESS: the ability ... loss of control over drug use, that define a state of addiction. Here, we review the types of molecular ...
The drug most frequently implicated as causing a drug fever is RMP: details are given in the entry on rifampicin. Drug-induced ... Untreated TB in pregnancy is associated with an increased risk of miscarriage and major fetal abnormality, and treatment of ... Drug-induced hepatitis is discussed in a separate section above. Pregnancy itself is not a risk factor for TB. Rifampicin makes ... The same scheme as is used for test dosing for drug-induced hepatitis (described below) may be used. ...
... predicting individual susceptibility to drug-induced adverse effects causing weight gain and related metabolic abnormalities. ... "Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain". ... Drug Discovery. 7 (4): 307-23. doi:10.1038/nrd2331. PMID 18323849. S2CID 22103245. Fosgerau K, Raun K, Nilsson C, Dahl K, Wulff ... Giuliani D, Neri L, Canalini F, Calevro A, Ottani A, Vandini E, Sena P, Zaffe D, Guarini S (July 2015). "NDP-α-MSH induces ...
Traish, Abdulmaged M. (2018). "The Post-finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to ... Foss, GL (January 1956). "Abnormalities of form and function of the human breast". Journal of Endocrinology. 14 (1): R6-R9. ... Thompson DF, Carter JR (1993). "Drug-induced gynecomastia". Pharmacotherapy. 13 (1): 37-45. doi:10.1002/j.1875-9114.1993. ... as the drug has been associated with inducing depression, anxiety and suicidal ideation, symptoms that are particularly common ...
... particular aspirin and nonsteroidal inflammatory drug-induced asthma syndromes) and rhinitis; glaucoma; various diseases of the ... nervous system; fractures, osteoporosis, and other bone abnormalities; pulmonary fibrosis; certain forms of malignant disease ... The following drugs that act on EP2 but also other prostaglandin receptors are in clinical use: Iloprost activates EP2, EP3, ... The following drugs are in development or proposed to be candidates for development as highly selective EP2 agonists for the ...
Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral ... that Palmer became the first to publish research demonstrating that if an overweight person who has liver-related abnormalities ... assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic ... assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic ...
... or drug-induced vasculitis, but is not diagnostic. ... and vascular wall abnormalities. Arteriography are not ... Usually due to a hypersensitivity reaction to a known drug. Drugs most commonly implicated are penicillin, sulphonamides and ... positive vasculitis identified best treatments depending on whether the goal is to induce remission or maintenance and ...
... is usually drug induced. Drugs associated with sulfhemoglobinemia include sulphonamides such as ... all serious medical abnormalities.[citation needed] This can be caused by taking medications that contain sulfonamides under ... Gopalachar AS, Bowie VL, Bharadwaj P (June 2005). "Phenazopyridine-induced sulfhemoglobinemia". Ann Pharmacother. 39 (6): 1128- ... even though a blood count test may not show any abnormalities in the blood. This discoloration is called cyanosis, and is ...
... drug-induced neutropenia). Additionally, acute neutropenia can be commonly seen from people recovering from a viral infection ... A bone marrow biopsy can identify abnormalities in myelopoesis contributing to neutropenia such as the stage of arrest in the ... The common causes of acquired agranulocytosis including drugs (non-steroidal anti-inflammatory drugs, antiepileptics, ... Neutropenia can be the result of a variety of consequences, including from certain types of drugs, environmental toxins, ...
Identifying whether or not abnormalities in these pathways cause myoclonus may help in efforts to develop drug treatments and ... drugs that induce sleep, and for glycine, an inhibitory neurotransmitter that is important for the control of motor and sensory ... and similar drugs, and is possibly a sign of high and/or rapidly increasing serum levels of these drugs. Myoclonic jerks caused ... chemical or drug poisoning, as a side effect of certain drugs (such as tramadol, quinolones, benzodiazepine, gabapentin, ...
... regulation observed in disease states as seen in cells from patients with polycystic kidney disease or leading to drug-induced ... The Ehrlich team hypothesizes that these abnormalities in function are consequences, at least in part, of altered intracellular ...
These conditions are listed below: Perinatal (during birth) cerebral injury Kernicterus Cerebrovascular diseases Drug induced ... neurological abnormalities other than dystonia, abnormalities on brain imaging, particularly in the basal ganglia. To further ... These drugs have fallen out of fashion due to various serious side effects: sedation, parkinsonism, and tardive dyskinesia. ... How to induce neuroplasticity. A new approach to rehabilitate dystonias. Galene editions 2012. Adam OR, Jankovic J (2007). " ...
To treat drug-induced amenorrhoea, stopping the medication on the advice of a doctor is a usual course of action. Looking at ... might correct abnormalities of Functional Hypothalamic Amenorrhoea (FHA) related to the condition of stress-related amenorrhoea ... Anti-psychotic drugs used to treat schizophrenia have been known to cause amenorrhoea as well. New research suggests that ... A woman in this situation may be unable to become pregnant, even with the help of drugs. Long-term amenorrhoea leads to an ...
... hematologic abnormalities, and systemic illness. Other synonymous names and acronyms include drug-induced hypersensitivity ... Like other SCARs-inducing drugs, DRESS syndrome-inducing drugs or their metabolites stimulate CD8+ T or CD4+ T cells to ... Bocquet H, Bagot M, Roujeau JC (December 1996). "Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with ... SCARs Adverse drug reaction Drug allergy Drug intolerance Drug tolerance List of skin conditions Eosinophilic myocarditis ...
Abnormalities in the skull baseEdit. Impaired venous outflow is often caused by a hypoplastic jugular foramen.[23] This causes ... Hyperthyroid induced craniosynostosis is a hormone mediated premature closure.[34] It is thought that the bone matures faster ... Environmental factors refer for example to maternal smoking and the maternal exposure to amine-containing drugs. Several ... Pfeiffer syndrome: abnormalities of the skull, hands, and feet wide-set, bulging eyes, an underdeveloped upper jaw, beaked nose ...
"Drug-induced diabetes mellitus". Expert Opinion on Drug Safety. 4 (6): 1097-109. doi:10.1517/14740338.4.6.1097. PMID 16255667. ... There are a number of rare cases of diabetes that arise due to an abnormality in a single gene (known as monogenic forms of ... Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus". Drugs. 65 (3): 385- ... due to an autoimmune induced loss of insulin-producing beta cells in the pancreas.[12][13] Diagnosis of diabetes is by blood ...
"Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A (March 2017). "Flutamide-induced hepatotoxicity: ... If retinoids are used there is a high risk of abnormalities occurring in the developing fetus; women of childbearing age are ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs. 20 ...
"Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings". RxList. Archived from ... a hormone that is considered goiter-inducing.[12][13] Levothyroxine is also used as interventional therapy in people with ... Given that no increased risk of congenital abnormalities have been demonstrated in pregnant women taking levothyroxine, therapy ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon Pocket ...
... using various drugs such as SSRI or tricyclic antidepressants,[17][18] Nonsteroidal anti-inflammatory drugs (NSAIDs),[19] ... Opioid-induced hyperalgesia may develop as a result of long-term opioid use in the treatment of chronic pain.[3] Various ... as well as mapping of the area of abnormality. ... and finding a suitable drug or drug combination that is ... February 2003). "Cytokine-induced sickness behavior". Brain Behav. 17 (Suppl 1): S112-8. doi:10.1016/S0889-1591(02)00077-6. ...
Kashin-Beck is a result of combinatorial environmentally induced by factors such as: toxic mould, contaminated grains by ... fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on ... "Inactivation of Pten in Osteo-Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth" ...
Foremost among these abnormalities is the fact that the neurons are usually harvested as neural stem cells from a fetus and are ... It has been used not only in the study of neuronal plasticity and information processing but also in drug and toxin effects on ... This can be done by inducing network bursts or by inputing specific patterns to the neurons, from which the network is expected ... However, confounding this experimental technique is the fact that normal neuronal development induces change in array-wide ...
"Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... The abnormalities seen in the SPECT images are very similar to those seen in people with cerebral vacuities and Creutzfeldt- ... In the brain, B. burgdorferi may induce astrocytes to undergo astrogliosis (proliferation followed by apoptosis), which may ... A hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was granted fast track designation by the U.S. Food and Drug ...
Structural abnormalities of the kidneys are identified with imaging tests. These may include Medical ultrasonography/ultrasound ... Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... Newer, so-called "biologic drugs" or monoclonal antibodies, are also used in these conditions and include rituximab, ... The history typically includes the present illness, family history, general medical history, diet, medication use, drug use and ...
This gene seems to pleiotropically lead to other abnormalities like increased metabolism, higher food consumption, accelerated ... and provide insight into pleiotropically induced adaptive divergence in other eukaryotes.[17] ... For drug pleiotropy, see Pleiotropy (drugs).. Simple genotype-phenotype map that only shows additive pleiotropy effects. G1, G2 ...
Injuries and cataracts affect the eye itself, while abnormalities such as optic nerve hypoplasia affect the nerve bundle that ... corticosteroid-induced; and 4) a heterogonous mechanism associated with structural change and chronic inflammation.[34] In ... become blind from incorrect diagnosis and from ineffectual prescription of drugs, antibiotics or steroids.[45] In addition, ... "Circadian rhythm abnormalities in totally blind people: incidence and clinical significance". J. Clin. Endocrinol. Metab. 75 ...
Drug-induced keratoderma. *psoriasis *Keratoderma blennorrhagicum. *keratosis: Seborrheic keratosis *Clonal seborrheic ... Abnormalities of dermal fibrous and elastic tissue. *Cutaneous condition stubs. Hidden categories: *All stub articles ...
Drug-induced tics and tics of organic origin ۳۳۳٫۳ G25.6 Stereotypic movement disorder F98.5 ... Gait abnormality. *راه رفتن قیچی‌وار. *Cerebellar ataxia. *راه رفتن پارکینسونی. *Marche a petit pas ...
Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ... Rasgon N. The relationship between polycystic ovary syndrome and antiepileptic drugs: a review of the evidence. J Clin ... Clinical features, hormonal profile, and metabolic abnormalities of obese women with obese polycystic ovary syndrome]. Zhonghua ... Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome. New England Journal of ...
Several drugs that have been approved by the FDA for other indications hold promise for treating chemically induced pulmonary ... Most of these abnormalities resolve with time. Functional changes (increased RL and/or bronchial responsiveness to inhaled ... Specific pretreatments, drugs to prevent chemically induced lung injuries due to respiratory airway toxins, are not available. ... Drugs that reduce the inflammatory response, promote healing of tissues, and prevent the onset of pulmonary edema or secondary ...
There is also a theory that long-term snoring might induce local nerve lesions in the pharynx in the same way as long-term ... Mason, M; Welsh, EJ; Smith, I (May 31, 2013). "Drug therapy for obstructive sleep apnoea in adults". The Cochrane Database of ... The operation may be far from trivial, especially in the worst apnea cases, in which growth is retarded and abnormalities of ... Temporary spells of OSA syndrome may also occur in individuals who are under the influence of a drug (such as alcohol) that may ...
Substance intoxication / Drug overdose. *Withdrawal. *Substance-induced psychosis. *SUD *Substance abuse / Substance use ... Congenital malformations, deformations and chromosomal abnormalities XVIII R00-R99 Symptoms, signs and abnormal clinical and ... F19) multiple drug use and use of other psychoactive substances (F20-F29) Schizophrenia, schizotypal and delusional disorders[ ... Benzodiazepine drug misuse Benzodiazepine dependence Benzodiazepine withdrawal syndrome (F14) use of cocaine Cocaine ...
BDNF is a regulator of drug addiction and psychological dependence. Animals chronically exposed to drugs of abuse show ... Research has reported that the interaction between BDNF and TrkB (the receptor to BDNF) is highly important in inducing ... Knockout mice also exhibit cerebellar abnormalities and an increase in the number of sympathetic neurons.[20] ... Yoshii A, Constantine-Paton M (June 2007). "BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA ...
During the same period, numerous experimental drugs have been shown to be neuroprotective in animal models of brain injury. ... CT abnormality. (9) The biomarker should allow for repeated detections in one of the above-mentioned biofluids within a 48 h ... and synapses are also subjected to TBI-induced damage [18,19]. Similarly, not only are neurons at risk for injury, but also ...
... is the only non-psychiatric drug on the FDA's top 10 list of drugs associated with depression[39][43] and is also ... Inhibition of hippocampal neurogenesis may also play a role in the development of isotretinoin-induced depression.[38] A ... and abnormalities in brain function. Isotretinoin is classified as FDA Pregnancy Category X and ADEC Category X, and use is ... Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth ...
"Listing of Drugs Currently Regulated as New Drugs (The New Drugs List)". www.hc-sc.gc.ca. Health Canada. 26 May 2016. Retrieved ... Changes in the activity of 5-HT neurons could explain the sleep-inducing action[41] However, failure of the GABAA receptor ... Clough, Alan R.; Bailie, Ross S.; Currie, Bart (1 January 2003). "Liver Function Test Abnormalities in Users of Aqueous Kava ... Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review" Drugs 2001;61(15):2163-75. ...
Peter Baluk, Hiroya Hashizume, Donald M. McDonald: Cellular abnormalities of blood vessels as targets in cancer. In: Current ... Cancer Drug Information. 5. Mai 2009. *↑ Mustafa Khasraw u. a.: Antiangiogenic therapy for high-grade glioma. . In: The ... Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and ...
... and drug sensitivity, sulfa and valproate toxicities[5] are examples. In some of these conditions, especially the drug-induced ... Singh, Nishith K.; Nagendra, Sanjai (2008). "Reversible Neutrophil Abnormalities Related to Supratherapeutic Valproic Acid ...
Drugs tested and not shown to be effective in clinical trials in humans include antiviral drugs, anti-excitotoxic drugs, growth ... The zebrafish has transparent embryos that can be injected with DNA or RNA and has a lifespan of up to two years.[79] Induced ... Specific abnormalities in the NCV results may suggest, for example, that the person has a form of peripheral neuropathy (damage ... "FDA approves drug to treat ALS". U.S. Food and Drug Administration. 5 May 2017. Archived from the original on 8 May 2017.. ...
"NYC Induced Abortion Summary by Woman's Race/Ethnicity". Retrieved 2016-10-10.. , NYC Dept of Health and Mental Hygiene, Office ... "Termination of Pregnancy for Fetal Abnormality" (PDF). Royal College of Obstetricians and Gynaecologists: 30. May 2010. ... and New Jersey allow qualified non-physicians to prescribe drugs for medical abortions only.[65] In all other states, only ... "Induced Abortion Facts in Brief" (2002) (13,000 out of 1.31 million abortions in 2000 were on account of rape or incest). ...
Cardiovascular late side effects have been termed radiation-induced heart disease (RIHD) and radiation-induced vascular disease ... Examples of radiosensitizing drugs include: Cisplatin, Nimorazole, and Cetuximab. The effect of radiotherapy on control of ... However, double-stranded DNA breaks are much more difficult to repair, and can lead to dramatic chromosomal abnormalities and ... injury to the plexus nerves presents as radiation-induced brachial plexopathy or radiation-induced lumbosacral plexopathy ...
Epigenetic Drugs Function Classification Drug ALS AD HD PD SMA DNA-methylation inhibitor chemical analogue of cytidine ... "Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3". ... sometimes leading to behavioral abnormalities (as with PD), and, ultimately, neuronal death, resulting in dementia. ... If the mice show improvement and the drug does not cause very many side effects or toxicity, the drug may be used in human ...
cellular response to drug. • cell cycle arrest. • learning or memory. • cellular copper ion homeostasis. • cellular response to ... Americo TA, Chiarini LB, Linden R (June 2007). "Signaling induced by hop/STI-1 depends on endocytosis". Biochem. Biophys. Res. ... However, more recent strains have shown significant cognitive abnormalities.[16]. As the null mice age, a marked loss of ... Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G (December 2005). "Recombinant prion protein induces rapid ...
Richardson, P. G. (12 July 2002). "Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients ... Four years after thalidomide was withdrawn from the market for its ability to induce severe birth defects, its anti- ... syndromes associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities in the U.S ... The drug was primarily prescribed as a sedative or hypnotic, but it was also used as an antiemetic and sedative. The drug was ...
Similar abnormalities have been identified in the brainstem and cerebellar dentate nucleus.[2] ... This stress is believed to contribute to the formation of free radicals in the brain tissue of animal models induced with SSADH ... ethosuximide and other anticonvulsant drugs. *GHB receptor antagonist NCS-382. *GABAA receptor modulators ... Elevations of GHB have been shown to induce spike and wave activity similar to that seen in generalized absence epilepsy in ...
Principles for the testing of drugs for teratogenicity : report of a WHO scientific group [‎meeting held in Geneva from 14 to ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎World Health ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Genève : ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Ginebra : ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T ... Principles for the testing of drugs for teratogenicity : report of a WHO scientific group [‎meeting held in Geneva from 14 to ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎World Health ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Genève : ...
2. Drug-Induced DM. Streptozotocin (STZ) and alloxan are often used for the induction of type 1 DM in animal models. These ... The evaluation of immune responses in the drug-induced DM models must be carefully considered. ... STZ doses of 65~70 mg/kg are often used for inducing type 1 DM in rats. In some studies, lower doses of STZ, 30~35 mg/kg, were ... To clarify the abnormality of G-K rats, immunological parameters of peripheral blood from G-K rats were compared to the ...
Drug-and Exercise-Induced Abnormalities Of Renal, Fluid, and Electrolyte Homeostasis. Southern medical journal. 1983 Jun;76(6): ... Drug-and Exercise-Induced Abnormalities Of Renal, Fluid, and Electrolyte Homeostasis. / Oster, James R.; Materson, Barry J. ... Oster, J. R., & Materson, B. J. (1983). Drug-and Exercise-Induced Abnormalities Of Renal, Fluid, and Electrolyte Homeostasis. ... Oster, James R. ; Materson, Barry J. / Drug-and Exercise-Induced Abnormalities Of Renal, Fluid, and Electrolyte Homeostasis. In ...
Results of search for su:{Abnormalities.} and su-to:Abnormalities, Drug-induced. ... Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins.. by Hawkins, Denis Frank ... Principles for the testing of drugs for teratogenicity : report of a WHO scientific group [meeting held in Geneva from 14 to 19 ... by WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity , World Health Organization ...
Some medicines can harm your baby, including over-the-counter drugs, herbs and supplements. ... ClinicalTrials.gov: Abnormalities, Drug-Induced (National Institutes of Health) Journal Articles References and abstracts from ... Index to Drug-Specific Information (Food and Drug Administration) * Prescription Opioids during Pregnancy (March of Dimes Birth ... Food and Drug Administration) Also in Spanish * Pregnancy and Medicines (Department of Health and Human Services, Office on ...
... drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ... Drug-Induced Lupus Erythematosus. Advise patients that drug-induced lupus erythematosus has been reported during the use of ... Table 2: Adverse Reactions and Laboratory Abnormalities in Patients with MS in Pooled Studies 1, 2, 3, and 4 ... Drug-Induced Lupus Erythematosus. Cases of drug-induced lupus erythematosus have been reported with some interferon beta ...
Abnormalities, Drug-Induced [‎10]‎. Abnormalities, Multiple [‎5]‎. ABO Blood-Group System [‎2]‎. ...
Current drug-induced psoriasis.. *Previous use of secukinumab or any drug that targets IL-17 or IL-17 receptor. ... Hematological abnormalities.. *History of an ongoing, chronic or recurrent infectious disease, or evidence of untreated ... Drug: Secukinumab 150mg Secukinumab 150mg: 1 injection of 150 mg secukinumab and 1 injection of placebo to secukinumab 150mg ... Drug: Secukinumab 300mg Secukinumab 300mg (2 injections of 150mg secukinumab per dose) ...
Current drug-induced psoriasis.. *Previous use of secukinumab or any drug that targets IL-17 or IL-17 receptor. ... Hematological abnormalities.. *History of an ongoing, chronic or recurrent infectious disease, or evidence of untreated ... Drug: secukinumab 150 mg secukinumab (AIN457) 150mg or 300mg subcutaneous. Drug: placebo to secukinumab 150 mg Placebo to Match ... Drug: secukinumab 150 mg secukinumab (AIN457) 150mg or 300mg subcutaneous. Drug: placebo to secukinumab 150 mg Placebo to Match ...
Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver ... Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver ... Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver ... Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver ...
Drug-Induced Hypothyroidism; Interpretation of Symptoms in Subclinical Hypothyroidism; Subclinical Hypothyroidism Skeletal ... Subclinical Hypothyroidism Metabolic Abnormalities; etc..." A CLINICAL EVALUATION OF THE THYROID IN HEALTH AND DISEASE: THE ... FOR DRUGS & MEDICATION SEE THE PHARMACY CENTER FOR ER/SURGERY SEE THE SURGERY CENTER Emergency Medicine Journals ACADEMIC ...
electrolyte abnormalities, drug induced arrhythmia). *Are known to be ineligible to take amiodarone (eg. active hepatitis, ... Ventricular Tachycardia (VT) Ablation or Escalated Drug Therapy (VANISH). The safety and scientific validity of this study is ... Ventricular Tachycardia (VT) Ablation or Escalated Drug Therapy. Official Title ICMJE Ventricular Tachycardia Ablation or ... Failed first-line antiarrhythmic drug therapy as defined by one of:. *Appropriate ICD therapy or sustained VT occurred while ...
78 patients received oral hypoglycaemic drugs during the 1st trimester and 93 did not. The outcome of pregnancy in these two ... Abnormalities, Drug-Induced * Administration, Oral * Birth Weight / drug effects * Diabetes Mellitus, Type 2 / drug therapy* ... Among the last 50 of the total of 75 viable infants whose mothers received oral drugs early in pregnancy, the PNM rate was 40/1 ... We conclude that modern oral hypoglycaemic drugs are safe and useful, not only during later pregnancy but also during the 1st ...
Abnormalities, Drug-Induced * Animals * Carcinogens / toxicity * DNA Damage * Environmental Exposure / adverse effects* ...
"Severe and Unrecognized Dental Abnormalities After Drug-Induced Epidermal Necrolysis". Arch. Dermatol. 145 (11): 1332-1333. doi ... Common environmental factors include infection, trauma and drugs which predispose to the condition. In hereditary cases, ... A relationship was also postulated between abnormalities of the brainstem and the presence of agenesis.[13] ... "Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study" ...
9.2.4 Other clinical manifestations of liver abnormalities 240. 9.3 Drug-induced liver injury 240 ... 1.6 Adverse events vs adverse drug reactions, and an overall view of safety evaluation 5 ... 8.3.2 Single-versus multiple-dose studies; co-administration of interacting drugs 199 ...
Drug induced: penicillins, cephalosporins, diuretics, nonsteroidal anti-inflammatory drugs, cyclophosphamide (Cytoxan), ... Identifying an abnormality in the upper urinary tract does not preclude evaluation of the lower urinary tract because a ... Drug induced: penicillins, cephalosporins, diuretics, nonsteroidal anti-inflammatory drugs, cyclophosphamide (Cytoxan), ... Routine use of warfarin (Coumadin) should not cause hematuria unless there is an underlying urologic abnormality.3 A brief ...
Abnormalities, Drug-Induced*. Abortion, Induced / statistics & numerical data*. Adult. Female. Follow-Up Studies. Humans. ...
... visceral and skeletal abnormalities induced by cyclophosphamide were investigated in rats. Pregnant rats were daily ... Abnormalities, Drug-Induced*. Animals. Aryl Hydrocarbon Hydroxylases / biosynthesis*, genetics. Camellia sinensis / chemistry* ... Drug Synergism. Female. Fetal Development / drug effects, physiology. Gene Expression Regulation, Developmental / drug effects ... abnormalities. When pre-treated with GTE, cyclophosphamide-induced body weight loss and abnormalities of fetuses were ...
This topic contains 1 study abstract on Drug-Induced Toxicity: Valproic Acid (Depakote) indicating that the following substance ... Hydrogen-rich water ameliorates autistic-like behavioural abnormalities in valproic acid-treated adolescent mice offspring.Dec ... Diseases : Chemically-Induced Liver Damage, Drug-Induced Toxicity: Valproic Acid (Depakote). Pharmacological Actions : ... 3 Abstracts with Drug-Induced Toxicity: Valproic Acid (Depakote) Research. Filter by Study Type. Animal Study. ...
History of drug-induced hematologic or hepatic abnormalities. *Anticipated requirement for long-term (,7 day) non-study ... Qualifying ischemic event induced by angiography or surgery.. *Severe non-cardiovascular comorbidity with life expectancy ,3 ... Drug: Clopidogrel Loading dose of 600mg followed by 75 milligrams, oral, one tablet daily for 89 days ... Drug: placebo Loading dose of 8 tablets followed by one tablet daily for 89 days ...
Its principal abnormality is diastolic dysfunction-specifically, restricted ventricular filling. ... Drug-induced RCM is a rare disorder that has been described with long-term use of the antimalarial medications chloroquine and ... These changes lead to abnormalities of contractility, conduction, and coronary blood flow. Interestingly, amyloid deposition in ... Hanna M. Novel drugs targeting transthyretin amyloidosis. Curr Heart Fail Rep. 2014 Mar. 11 (1):50-7. [Medline]. ...
5.10 Drug-Induced Hepatitis. Sorafenib-induced hepatitis is characterized by a hepatocellular pattern of liver damage with ... The following additional drug-related adverse reactions and laboratory abnormalities were reported from clinical trials of ... Severe drug-induced liver injury [see Warnings and Precautions (5.10)] Dose modifications for Hepatocellular Carcinoma and ... Drug-Induced Hepatitis [see Warnings and Precautions (5.10)] • Impairment of TSH suppression in DTC [see Warnings and ...
Drug-induced lung disease. * Eosinophilic pneumonias. * Follicular bronchiolitis. * Growth abnormalities. * Hypersensitivity ... Radiation-induced lung disease. * Surfactant gene mutation-associated lung disease (SP-B, SP-C, ABCA3, TTF-1, GM-CSF receptor) ...
congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99). *endocrine, nutritional and metabolic diseases ... Drug-induced myopathy. 2016 2017 2018 2019 2020 Billable/Specific Code *G72.0 is a billable/specific ICD-10-CM code that can be ... Steroid-induced myopathy. ICD-10-CM G72.0 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0): *091 Other disorders of ... The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth ...
congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99). *endocrine, nutritional and metabolic diseases ... Drug-induced chronic gout, unspecified hip, with tophus (tophi). 2016 2017 2018 2019 2020 Billable/Specific Code *M1A.2591 is a ... Drug-induced chronic gout. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Use Additional*code for adverse effect, if ... Short description: Drug-induced chronic gout, unspecified hip, with tophus. *The 2020 edition of ICD-10-CM M1A.2591 became ...
Drug-induced thrombocytopenia requires a high suspicion for diagnosis and a broad investigation to exclude other etiologies of ... Flow cytometry of bone marrow revealed no significant immunophenotypic abnormalities.. Azithromycin was discontinued. ... W. Lerner, R. Caruso, D. Faig, and S. Karpatkin, "Drug-dependent and non-drug-dependent antiplatelet antibody in drug-induced ... drug-induced thrombocytopenia is considered probable. Meeting criteria 1 suggests possible diagnosis of drug-induced ...
Mantel-Teeuwisse, A.K., Klungel, O.H. & de Boer, A. (2001). Lipid abnormalities induced by novel antipsychotic drugs. Drug ... Drug-Induced lipid changes - a review of the unintended effects of some commonly used drugs on serum lipid levels. Drug Safety ... Drug-Induces Lipid Changes. Drug Safety, 24 (6), (pp. 443-456) (14 p.). ... Drug Metabolism and Drug Interactions, 27 (3), (pp. 11) (1 p.). Saxena, Richa, Elbers, Clara C., Guo, Yiran, Peter, Inga, Gaunt ...
22q11 Deletion Syndrome; Abnormalities, Drug-Induced; Abortion, Threatened; Agenesis of Corpus Callosum; Amniotic Fluid; Aortic ... Congenital Abnormalities; Fetal Diseases; Heart Defects, Congenital; Pregnancy Complications Clinical Interests. ...
  • Curcumin and NAC protect against valproate-induced liver toxicity. (greenmedinfo.com)
  • Boelsterli UA (2003) Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. (springer.com)
  • Bort R, Ponsoda X, Jover R, Gómez-Lechón MJ, Castell JV (1999) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. (springer.com)
  • More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
  • A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
  • Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
  • Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
  • The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
  • Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
  • If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
  • In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
  • Then, the comparison research between ethyl acetate extract (EAE) and n-butanol extract (BUE) suggested that liver toxicity was mainly induced by BUE. (mdpi.com)
  • The mechanical study suggested that BUE-induced liver toxicity was closely associated with necrosis detected by MTT and propidium iodide (PI) staining, via releasing lactate dehydrogenase (LDH), reducing the fluidity, and increasing the permeability of the cell membrane. (mdpi.com)
  • This finding indicated that the liver toxicity induced by BUE from P. hookeri was mainly caused by necrosis, which provides an important theoretical support for further evaluation of the safety of this folk medicine. (mdpi.com)
  • 1) Pterocephalus hookeri could induce liver toxicity in vivo and in vitro. (mdpi.com)
  • Some of the most commonly prescribed drugs are involved in the pathogenesis of kidney and liver toxicity, including antibiotics, acetaminophen (Tylenol), NSAIDs (e.g., ibuprofen), and ACE inhibitors. (nurse.com)
  • Therefore, it is imperative that nurses, physicians, physician's assistants, nurse practitioners, and pharmacists are aware of which agents commonly cause kidney or liver injury, symptoms that may indicate toxicity, abnormalities in lab values that indicate kidney or liver injury, and potential preventive measures. (nurse.com)
  • The goal of this continuing education program is to provide physicians, pharmacists, nurses, nurse practitioners, and physician's assistants with an in-depth understanding of common drugs and other agents that are nephrotoxic or hepatotoxic, while providing them with the tools needed to perform their roles as members of the healthcare team working collaboratively to prevent and manage cases of kidney and liver toxicity. (nurse.com)
  • Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary CNS pathology. (mentalhealth.com)
  • Rheumatoid arthritis is two goals: Evaluate for toxicity drug holidays or structured treatment interruptions have depends on malabsorption due to long infusion times (hours), chronic disease is sometimes transmission. (goodbelly.com)
  • In some cases of benign AN, associated skin abnormalities may be present at birth (congenital). (rarediseases.org)
  • Thalidomide and congenital abnormalities. (springer.com)
  • Morphologically, DIHVD can be defined echocardiographically as abnormal thickening of valve leaflets, or cusps, resulting in a restrictive motion in the absence of carcinoid syndrome, left ventricular remodelling (ie, ischaemic valve involvement), rheumatic VHD, Libman-Sacks endocarditis and congenital abnormalities. (bmj.com)
  • Electrolyte abnormalities are common in both outpatient and inpatient settings. (arupconsult.com)
  • Uncorrected electrolyte abnormalities may have life-threatening consequences. (arupconsult.com)
  • Acid-base and electrolyte abnormalities observed in patients receiving cardiovascular drugs. (nih.gov)
  • Cardiovascular drugs can cause a variety of acid-base and electrolyte abnormalities that need to be considered when clinicians manage the large number of patients who receive these agents. (nih.gov)
  • Electrolyte abnormalities should be corrected. (scribd.com)
  • Many recreational and prescription drugs can induce psychotic symptoms that can mimic serious psychiatric disorders. (mentalhelp.net)
  • Drug-induced tendon disorders are an often underestimated risk factor. (springer.com)
  • Miller LG, Jankovic J (1990) Neurologic approach to drug-induced movement disorders: a study of 125 patients .South Med J 1990 May;83(5):525-32. (ahrp.org)
  • Of 125 patients with neuroleptic (dopamine blocking) drug-induced movement disorders who had been referred to a specialized clinic to differentiate the predominant movement disorder, 63% had tardive dyskinesia, 30% had parkinsonism, 24% had dystonia, 7% had akathisia, and 2% had isolated tremor. (ahrp.org)
  • A differential diagnosis with hyperpigmentation caused by endocrine and metabolic disorders, the most closely-related disorders to drug-induced hyperpigmentation, and with hyperpigmentation of idiopathic origin, should be conducted. (jabfm.org)
  • Abnormalities include hereditary and acquired cell membrane disorders (eg, spherocytosis), disorders of RBC metabolism (eg, G6PD deficiency ), and hemoglobinopathies (eg, sickle cell diseases , thalassemias ). (merckmanuals.com)
  • A number of drugs are known to cause QT prolongation (e.g., terfenadine), as are hypokalemia, hypomagnesemia, myocarditis, and endocrine and nutritional disorders. (aafp.org)
  • Abnormalities include hereditary cell membrane disorders (eg, hereditary spherocytosis ), acquired cell membrane disorders (eg, paroxysmal nocturnal hemoglobinuria ), disorders of RBC metabolism (eg, glucose-6-phosphate dehydrogenase (G6PD) deficiency ), and hemoglobinopathies (eg, sickle cell disease , thalassemias ). (merckmanuals.com)
  • To review the salivary secretory disorders, inducing drugs and their clinical management. (medsci.org)
  • Drug-induced hepatic injury, including fatalities, have been reported. (drugs.com)
  • Drug-induced thrombocytopenia requires a high suspicion for diagnosis and a broad investigation to exclude other etiologies of low platelets. (hindawi.com)
  • Drug-induced thrombocytopenia can result in severe, progressive reductions in platelet counts with resultant sequelae of bleeding [ 1 - 3 ]. (hindawi.com)
  • Identification of drug-induced thrombocytopenia is important as the condition is reversible upon discontinuing the medicine [ 4 , 5 ]. (hindawi.com)
  • Drug-induced immune thrombocytopenia is attributed to decreased platelet production secondary to myelosuppression or accelerated platelet destruction secondary to an immune response [ 1 ]. (hindawi.com)
  • Drug-induced thrombocytopenia can present with asymptomatic thrombocytopenia, hemolytic-uremic syndrome (HUS), or thrombotic thrombocytopenia purpura (TTP) in extreme cases [ 2 ]. (hindawi.com)
  • Drug-induced thrombocytopenia results in severely decreased platelet counts, often less than 20,000/ μ L [ 3 ]. (hindawi.com)
  • In most circumstances, a week's duration is often needed for the offending drug to induce thrombocytopenia. (hindawi.com)
  • How is drug-induced thrombocytopenia platelet disorder diagnosed? (medscape.com)
  • The diagnosis of drug-induced thrombocytopenia is often empirical. (medscape.com)
  • A temporal relationship must be present between the initiation of the drug and the development of thrombocytopenia, with no other explanations for the thrombocytopenia. (medscape.com)
  • Recurrent thrombocytopenia following reexposure to the drug confirms the drug as the cause of thrombocytopenia. (medscape.com)
  • Identifying the drug that is causing severe thrombocytopenia in an acutely ill patient who is taking multiple drugs is often challenging. (medscape.com)
  • A complete list of all available reports of drug-induced thrombocytopenia is available at Platelets on the Web . (medscape.com)
  • Heparin-induced thrombocytopenia. (medscape.com)
  • Drug-induced thrombocytopenia is common in hospitalized patients. (psychiatryadvisor.com)
  • OBJECTIVES: The long-term outcomes of patients with drug induced liver injury (DILI) are not well described. (elsevier.com)
  • DILIN Investigators 2015, ' Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury ', The American Journal of Gastroenterology , vol. 110, no. 10, pp. 1450-1459. (elsevier.com)
  • de Abajo FJ, Montero D, Madurga M, GarcÃa RodrÃguez LA (2004) Acute and clinically relevant drug-induced liver injury: a population based case-control study. (springer.com)
  • Drug-induced kidney and liver injury is a major problem throughout the world. (nurse.com)
  • This meets criteria for mild drug-induced liver injury. (cochrane.org)
  • On one instance this was linked to raised bilirubin, indicating moderate drug-induced liver injury. (cochrane.org)
  • No episodes of severe drug-induced liver injury were reported. (cochrane.org)
  • Characteristics of Brazilian case reports of drug-induced liver injury. (elsevier.es)
  • Comparison between Brazilian and international studies on drug-induced liver injury. (elsevier.es)
  • This study aimed to summarize case reports of herb- and drug-induced liver injury in Brazil. (elsevier.es)
  • Drugs ( n = 29) were a more frequent cause of liver injury than herbs ( n = 3). (elsevier.es)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
  • 4 Diagnostic tools, including imaging, do not always identify structural abnormalities. (cmaj.ca)
  • To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
  • Drugs used for the treatment of Parkinson's disease and endocrine diseases, like hyperprolactinemia, may also induce VHD. (bmj.com)
  • This condition may follow certain diseases such as syphilis, or can result from fever, trauma, systemic upsets or adverse reaction to drugs. (wikipedia.org)
  • 1 Subsequently, drugs used for the treatment of Parkinson's disease and endocrine disease like hyperprolactinemia were also shown to induce VHD 2 More recently, the use of 3,4-methylendioxymetamphetamine (MDMA, 'Ecstasy') and benfluorex (as adjuvant therapy for dyslipidemia in diabetic patients) have also been found to be associated with DIVHD. (bmj.com)
  • Efavirenz-induced hypersensitivity reaction with hepatitis and rash. (nih.gov)
  • Efavirenz-induced hypersensitivity reaction manifesting in rash and hepatitis in a Latino male. (nih.gov)
  • Heparin causes a unique situation among drug-induced thrombocytopenias in that the antibodies also activate platelets and induce a hypercoagulable state. (medscape.com)
  • The effects of green tea extract (GTE) on the fetal development and external, visceral and skeletal abnormalities induced by cyclophosphamide were investigated in rats. (biomedsearch.com)
  • On the 20th day of gestation, maternal and fetal abnormalities were determined by Cesarian section. (biomedsearch.com)
  • Considering drug therapy for pregnant women, it is certain that almost all chemical compounds in use as therapeutic agents pass from the maternal to the fetal circulation through the placenta. (springer.com)
  • Pardeshi R., Mane A. (2016) Drug-Induced Serious Maternal and Fetal Complications in Pregnancy. (springer.com)
  • The usual treatment for postterm pregnancy is to periodically check the fetal heartbeat until labor starts on its own or is induced (started artificially). (howstuffworks.com)
  • A fetal monitor is generally used to detect any abnormalities of the fetal heartbeat. (howstuffworks.com)
  • The incidence of drug-induced hyperpigmentation was 1.31% in patients attending a first dermatology consultation in the study period. (jabfm.org)
  • This condition can be suspected if the patient has been exposed to a likely causative drug, develops new signs and symptoms, and has a remittence of these symptoms once the drug is withheld. (medscape.com)
  • Because treatment modalities can vary, it is important to distinguish whether psychotic symptoms are substance-induced or caused by other factors [1]. (mentalhelp.net)
  • After long periods of use, some drugs can cause psychotic symptoms which mimic those experienced by individuals with schizophrenia , bipolar disorder , or other mental illnesses involving psychosis [1,2,3]. (mentalhelp.net)
  • However, certain drugs are more likely to cause psychotic symptoms than others. (mentalhelp.net)
  • However, these symptoms typically cease when the drug wears off. (mentalhelp.net)
  • Clinical symptoms of LTG-induced CADR range from maculopapular exanthema (MPE) to severe cutaneous adverse reactions (SCAR). (frontiersin.org)
  • and 1 drug reaction with eosinophilia and systemic symptoms] and 50 LTG-tolerant controls were included in the study. (frontiersin.org)
  • Unfortunately, not all persons with long QT syndrome have premonitory symptoms or identifiable electrocardiographic abnormalities, and they may first present with sudden death. (aafp.org)
  • If signs and symptoms of tardive dyskinesia appear in a patient on neuroleptics, drug discontinuation should be considered. (mentalhealth.com)
  • Clinical symptoms of targeted therapy-induced ILD are nonspecific, including cough, shortness of breath, low-grade fever, and hypoxemia [ 3 ]. (omicsonline.org)
  • What are the clinical symptoms of drug-induced nail disease? (dermnetnz.org)
  • And which drugs cause which symptoms? (dermnetnz.org)
  • The signs and symptoms of drug-induced nail disease depend on the specific drug. (dermnetnz.org)
  • Although patients, families and the public were not informed - some would argue they were deceived - clinical psychiatrists and researchers have long known about severe adverse drug reactions (ADR) and disabling changes in the central nervous system in a high percentage of patients taking standard neuroleptic drugs. (ahrp.org)
  • CE findings of NSAID-induced enteropathy range from erosions or ulcers to severe lesions such as diaphragms. (springer.com)
  • DIVHD is not infrequent, may be severe, and has been described in association with several drugs. (bmj.com)
  • Treatment interruption and/or dose reduction may be needed to manage suspected adverse drug reactions. (nih.gov)
  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5. (icd10data.com)
  • Before starting patients on any medication, educate them about the potential adverse effects of the drug. (medscape.com)
  • These, and a host of other adverse side effects, cause most schizophrenia patients to stop taking these drugs. (ahrp.org)
  • It is one of the common cause of cutaneous adverse drug reactions (CADR). (frontiersin.org)
  • Although hepatotoxicity accounts for 10% of adverse drug reactions, it remains poorly understood and underreported. (elsevier.es)
  • The pulmonary toxicities , especially drug induced-interstitial lung disease (ILD), have emerged as critical adverse drug reactions which are potentially fatal.The main managment of targeted therapy-induced ILD includes drug discontinuation and corticosteroid therapy , but no standard guideline for the treatment of targeted therapy-induced ILD was established. (omicsonline.org)
  • The pulmonary toxicities, especially drug induced- interstitial lung disease (ILD), have emerged as critical adverse drug reactions. (omicsonline.org)
  • Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. (elsevier.com)
  • The present report presents the case of a 45‑year‑old female patient who was previously diagnosed in January 2010 with terbinafine‑induced subacute cutaneous lupus erythematosus and was admitted for a skin eruption consisting of erythematous‑papular erythema multiforme‑like lesions, primarily on the trunk and limbs. (spandidos-publications.com)
  • Let us talk about what causes drug-induced diarrhea, by category. (medscape.com)
  • Drug-dependent anti-platelet antibody testing was not done during admission as the patient's platelet count began to slowly improve after stopping the azithromycin. (hindawi.com)
  • 7 day) non-study antiplatelet drugs (e.g., dipyridamole, clopidogrel, ticlopidine), or NSAIDs affecting platelet function (such as prior vascular stent or arthritis). (bmc.org)
  • Molecular abnormalities in Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand's disease. (medscape.com)
  • Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
  • The aim of this study was to determine the frequency and severity of persistent liver biochemistry abnormalities in DILI patients followed over 2 years. (elsevier.com)
  • The purpose of this study is to evaluate the optimal management of patients presenting with recurrent VT and receiving ICD therapy in spite of first-line antiarrhythmic drug therapy. (clinicaltrials.gov)
  • This is a multicentre, parallel group, two arm, unblinded, randomized clinical trial to compare two management strategies for patients with ischemic heart disease and recurrent ICD therapy despite at least one antiarrhythmic drug. (clinicaltrials.gov)
  • 78 patients received oral hypoglycaemic drugs during the 1st trimester and 93 did not. (nih.gov)
  • One-third of epileptic patients are drug refractory due to the limited efficacy of antiepileptic therapy. (eurekaselect.com)
  • And, they noted, "psychiatrists who are critical of the profession's lax treatment of the problem argue that if doctors were really concerned, they would reduce their use of neuroleptics and reduce dosages when drugs are employed…" and they would fully disclose the risks of TD to their patients. (ahrp.org)
  • This review focuses on the pathogenetic mechanisms as well as on the treatment of these metabolic derangements that are commonly encountered in patients who receive cardiovascular drugs. (nih.gov)
  • Mucosal abnormalities of the small bowel in patients with cirrhosis and portal hypertension: a capsule endoscopy study. (springer.com)
  • 3.2% (194/5995) of Asian patients and 1.8% (100/5641) of Caucasian patients experienced liver function test abnormalities. (drugs.com)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • We studied drug-induced hyperpigmentation in patients attending an outpatient dermatology clinic in the Western Area of Valladolid (Spain) from August 1, 2017 to April 20, 2018. (jabfm.org)
  • Of the 16 patients, 8 were taking more than 1 drug. (jabfm.org)
  • Drug-induced hyperpigmentation is a relatively frequent reason for consultation, especially in polypharmacy patients. (jabfm.org)
  • The sample may have been biased as many patients receiving treatments frequently associated with drug-induced hyperpigmentation, such as antineoplastic drugs, are diagnosed and treated by other specialties, such as oncologists. (jabfm.org)
  • Drug-induced hyperpigmentation is estimated to account for 10% to 20% of cases of acquired hyperpigmentation, 4 although these figures are probably highly speculative, as most cases are idiopathic, especially in elderly patients. (jabfm.org)
  • Although some of these drugs were withdrawn from the market, several cases of patients requiring valve surgery even years after the cessation of therapy have been reported. (bmj.com)
  • This study aimed to determine the association of the LTG-induced CADR with human leukocyte antigen ( HLA ) alleles in Thai patients. (frontiersin.org)
  • HLA-A ∗ 02:07 and HLA-B ∗ 15:02 were associated with LTG-induced CADR in Thai patients. (frontiersin.org)
  • It is also contraindicated in patients with suspected or established subcortical brain damage, with or without hypothalamic damage, since a hyperthermic reaction with temperatures in excess of 40°C may occur in such patients, sometimes not until 14 to 16 hours after drug administration. (mentalhealth.com)
  • Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary dyskinetic movements, may develop in patients treated with neuroleptic (antipsychotic) drugs. (mentalhealth.com)
  • Chronic neuroleptic treatment should generally be reserved for patients who suffer from a chronic illness that, 1) is known to respond to neuroleptic drugs, and 2) for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. (mentalhealth.com)
  • 85 patients presenting to the unit underwent three EEGs with differing protocols: routine EEG (r-EEG), sleep-deprived EEG (SD-EEG), EEG carried out during drug-induced sleep (DI-EEG). (bmj.com)
  • Of the 85 patients who completed the study, 33 (39%) showed no discernible abnormality on any of their EEG recordings. (bmj.com)
  • New findings published in the New England Journal of Medicine reveal that the three drugs, levetiracetam, fosphenytoin, and valproate, are equally safe and effective in treating patients with refractory status epilepticus. (cureepilepsy.org)
  • XELJANZ ® (tofacitinib) is approved in the U.S. for adult patients in three indications: moderately to severely active rheumatoid arthritis (RA) after methotrexate failure, active psoriatic arthritis (PsA) after disease modifying antirheumatic drug (DMARD) failure and moderately to severely active ulcerative colitis (UC) after tumor necrosis factor inhibitor (TNFi) failure. (businesswire.com)
  • XELJANZ/XELJANZ XR (tofacitinib) is indicated for the treatment of adult patients with active psoriatic arthritis who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs). (businesswire.com)
  • Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)
  • D/C culprit drugs immediately Control the Arrhythmia by increasing the heart rate. (scribd.com)
  • In 1 to 5 percent of deaths, however, no anatomic abnormality can be found, and this group constitutes the newly described "sudden arrhythmia death syndrome" (SADS). (aafp.org)
  • Diuretic-induced metabolic alkalosis is the most common acid-base disorder observed and is associated with hypokalemia. (nih.gov)
  • Qualifying ischemic event induced by angiography or surgery. (bmc.org)
  • Various benign (non-cancerous) forms of AN have been identified in which the disorder may be inherited as a primary condition or associated with various underlying syndromes, an excess accumulation of body fat (obesity), or the use of certain medications (i.e., drug-induced AN). (rarediseases.org)
  • At present, there are numerous frequently prescribed drugs whose unwanted effects include some kind of salivary disorder. (medsci.org)
  • Hemostasis Testing Abnormalities without Clinical Bleeding: Abnormalities may be present on screening laboratory testing that suggest a bleeding disorder in individuals. (psychiatryadvisor.com)
  • It is frequently associated with an internal disorder, trauma, infection, nail fungi, allergy to nail enhancement products, or side effects of drugs. (wikipedia.org)
  • Portal hypertensive enteropathy can be classified into mucosal inflammatory-like abnormalities and vascular lesions. (springer.com)
  • We also show that DC101 induces a hydrostatic pressure gradient across the vascular wall, which leads to a deeper penetration of molecules into tumors. (aacrjournals.org)
  • METHODS: The dose and time course of the effects of fenfluramine (i.p.) on audiogenic seizures (Sz) induced by an electric bell in DBA/1 mice were determined. (cureepilepsy.org)
  • Notably, in this case there was a co‑occurrence of subacute lupus erythematosus and Rowell syndrome lesions, which was drug-induced. (spandidos-publications.com)
  • In an article written in 1986, Tardive Dyskinesia: Barriers to the Professional Recognition of Iatrogenic Disease , [Journal of Health and Social Behavior,1986, 27: 116-132], Brown and Funk stated: "tardive dyskinesia (TD), once regarded by psychiatrists as a rare syndrome, is currently recognized as the second most pervasive side effect following sedation of antipsychotic drugs. (ahrp.org)
  • In addition to a prolonged QT interval, which occurs in some but not all persons with long QT syndrome, another characteristic electrocardiographic abnormality is the so-called Brugada sign (an upward deflection of the terminal portion of the QRS complex). (aafp.org)
  • Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of neuroleptic drugs administered to the patient increase. (mentalhealth.com)
  • Neuroleptic malignant syndrome, a potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. (mentalhealth.com)
  • It usually occurs as part of a syndrome that involves other abnormalities and requires multidisciplinary treatment. (wikipedia.org)
  • Drug-using mothers often give birth to "drug babies," who go on to have a whole host of developmental problems. (springer.com)
  • Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cells or over time) of these parameters. (frontiersin.org)
  • Human ATRX mutations are associated with cognitive deficits, developmental abnormalities, and cancer. (jci.org)
  • 94.6%, 41.5% and 100% of the external (skull and limb defects), visceral (cleft palate and ureteric dilatation) and skeletal (acrania, vertebral/costal malformations and delayed ossification) abnormalities. (biomedsearch.com)
  • This refers to the ability of perinatally consumed drugs and food additives and nonprescription alternative agents to produce subtle biochemical defects that are undetectable or unrecognized in the neonate but that are expressed years, even decades, after birth. (springer.com)
  • Birth defects are abnormalities that occur in babies which affect how the body looks, works or both. (medindia.net)
  • Birth defects are abnormalities, which occur before the birth of the baby and can be caused due to genetic, environmental and other unknown reasons. (medindia.net)
  • Birth defects are abnormalities of function, structure or metabolism that are present since birth. (medindia.net)
  • Taking certain drugs during pregnancy can cause birth defects. (medindia.net)
  • Defects intrinsic to the RBC that can cause hemolysis involve abnormalities of the RBC membrane, cell metabolism, or hemoglobin structure. (merckmanuals.com)
  • Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. (springer.com)
  • Brain disease, metabolic failure, or drugs can dull the normal signals that give rise to the urge to defecate. (britannica.com)
  • The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure-induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation. (cureepilepsy.org)
  • The serotonin hypothesis of SUDEP is based on findings that treatments which modify serotonergic function significantly alter susceptibility to seizure-induced sudden death in several epilepsy models, including DBA/1 mice. (cureepilepsy.org)
  • SIGNIFICANCE: This study presents the first evidence for the effectiveness of fenfluramine in reducing seizure incidence, severity, and seizure-induced respiratory arrest susceptibility in a mammalian SUDEP model. (cureepilepsy.org)
  • clearly demonstrated that STZ both directly and indirectly induces suppressive effect on lymphocytes in mice [ 3 ]. (hindawi.com)
  • Hydrogen-rich water ameliorates autistic-like behavioural abnormalities in valproic acid-treated adolescent mice offspring. (greenmedinfo.com)
  • Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. (springer.com)
  • Subcutaneous injection of the 1,4-DPCA/hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased stable expression of HIF-1α protein over 5 days, providing a functional measure of drug release in vivo. (sciencemag.org)
  • Therefore, we investigated the effects of fenfluramine on seizures and seizure-induced respiratory arrest (S-IRA) in DBA/1 mice. (cureepilepsy.org)
  • Any structural abnormality involving the coronary arteries, valves or ventricles that is suspected to be the main cause of sudden cardiac death. (cmaj.ca)
  • Simultaneous voltage and calcium imaging with genetically encoded reporters provides a new approach for monitoring cardiac development, and the effects of drugs on cardiac function. (frontiersin.org)
  • In approximately 5 percent of sudden cardiac deaths, no demonstrable anatomic abnormality is found. (aafp.org)
  • A blood smear was performed and ruled out drug-induced thrombotic microangiopathy. (hindawi.com)
  • Inflammatory lesions of the small bowel, other than those found in inflammatory bowel disease (IBD), are diverse and can result from a variety of insults including nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy, infectious disease such as tuberculous or cytomegalovirus enteritis, ischemia, and others. (springer.com)
  • Furthermore, nucleosides and their derivatives may be safe and effective potential drugs in the treatment of epilepsy. (eurekaselect.com)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
  • Family physicians and specialists should consider drugs as a cause of hyperpigmentation to facilitate the correct diagnosis and treatment. (jabfm.org)
  • The present treatment of solid tumors is plagued by two problems: physiological barriers impair the delivery of therapeutic agents in optimal quantities, and genetic and epigenetic mechanisms contribute to drug resistance. (aacrjournals.org)
  • To unravel the mechanism of IFP reduction induced by blocking VEGF signaling, we examined the effect of DC101 on the determinants of interstitial hypertension, including changes in the morphology, wall structure, and function of tumor vasculature during the course of treatment. (aacrjournals.org)
  • If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. (mentalhealth.com)
  • Usually during antibiotic treatment, primary cicatricial alopecia: Lymphocytic pri- mary position with meticulous and gentle stomal stenosis can also be well tolerated and offers a second-line drug. (goodbelly.com)
  • Hemostasis Testing Abnormalities without Clinical Bleeding: In a patient who is not bleeding but who has coagulation testing abnormalities, further evaluation to determine the cause of the coagulation test abnormality should be performed prior to any treatment. (psychiatryadvisor.com)
  • Xanthurenic aciduria, cystathioninuria, and homocystinuria resulting from genetic abnormalities may respond to high doses of pyridoxine. (drugs.com)
  • The detection of Alzheimer's disease-specific differences in PP2A function and related events in peripheral tissues provides the basis for highly practical and efficient tests and diagnostic test kits for the early diagnosis of Alzheimer's disease, as well as providing a biochemical basis for identifying therapeutic targets for drug development. (google.com)
  • Drug-induced valvular heart disease (DIVHD) was first described in the 1960s. (bmj.com)
  • Among the last 50 of the total of 75 viable infants whose mothers received oral drugs early in pregnancy, the PNM rate was 40/1 000. (nih.gov)
  • We conclude that modern oral hypoglycaemic drugs are safe and useful, not only during later pregnancy but also during the 1st trimester, provided excellent control of blood glucose levels is achieved. (nih.gov)
  • In general, dosage recommendations for other oral forms of the drug may be applied to Spansule® brand sustained release capsules on the basis of total daily dosage in milligrams. (rxlist.com)
  • Dietary supplementation with creatine monohydrate prevents corticosteroid-induced attenuation of growth in young rats. (greenmedinfo.com)
  • Representative image of the skin lesions observed, en cocarde covered by scales that were only adherent in the center of the lesions and exhibited a pale center on the posterior trunk. (spandidos-publications.com)
  • 153 154 155 Used to correct marked neurologic effects (e.g., seizures, coma) induced by methylhydrazine (produced by hydrolysis of the toxins in these mushrooms). (drugs.com)
  • Common environmental factors include infection, trauma and drugs which predispose to the condition. (wikipedia.org)
  • Drug-induced nail disease is more common overall in older persons and those exposed to multiple medicines. (dermnetnz.org)
  • This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. (mdpi.com)
  • Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins. (who.int)
  • Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA. (biomedsearch.com)
  • The ability of fenfluramine to block seizure-induced respiratory arrest selectively suggests the potential usefulness of fenfluramine in prophylaxis of SUDEP. (cureepilepsy.org)
  • Boelsterli UA, Lim PL (2007) Mitochondrial abnormalities-a link to idiosyncratic drug hepatotoxicity? (springer.com)
  • The present-day definitions of Osteoporosis and Osteopenia were arbitrarily conceived by the WHO in the early 90's and then projected upon millions of women's bodies seemingly in order to convince them they had a drug-treatable, though symptomless, disease. (greenmedinfo.com)
  • It may be used as monotherapy or in combination with methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs). (businesswire.com)
  • Drug-induced nail disease is diagnosed when a medication affects nail growth or structure. (dermnetnz.org)
  • In general, the higher the dose of the drug, the more likely it is to cause nail disease. (dermnetnz.org)
  • Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth. (biomedsearch.com)