Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Malformations of organs or body parts during development in utero.
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
Congenital absence of or defects in structures of the eye; may also be hereditary.
Mapping of the KARYOTYPE of a cell.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.
Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
A characteristic symptom complex.
Congenital structural abnormalities of the skin.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The possession of a third chromosome of any one type in an otherwise diploid cell.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Congenital structural abnormalities and deformities of the musculoskeletal system.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Congenital absence of or defects in structures of the teeth.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
An infant during the first month after birth.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Elements of limited time intervals, contributing to particular results or situations.
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Actual loss of portion of a chromosome.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Mice bearing mutant genes which are phenotypically expressed in the animals.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An individual in which both alleles at a given locus are identical.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An individual having different alleles at one or more loci regarding a specific character.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Congenital structural abnormalities of the DIGESTIVE SYSTEM.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Congenital structural deformities of the upper and lower extremities collectively or unspecified.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
A variation from the normal set of chromosomes characteristic of a species.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The hollow, muscular organ that maintains the circulation of the blood.
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Disease having a short and relatively severe course.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Biochemical identification of mutational changes in a nucleotide sequence.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Recording of electric potentials in the retina after stimulation by light.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Congenital structural abnormalities of the respiratory system.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Congenital absence of or defects in structures of the jaw.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
Dominance of one cerebral hemisphere over the other in cerebral functions.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
The measurement of an organ in volume, mass, or heaviness.
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
Any method used for determining the location of and relative distances between genes on a chromosome.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Refers to animals in the period of time just after birth.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Use of reflected ultrasound in the diagnosis of intracranial pathologic processes.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
Genes that influence the PHENOTYPE only in the homozygous state.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Diseases affecting the eye.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Congenital absence of or defects in structures of the mouth.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
Contractile activity of the MYOCARDIUM.
Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.
The observable response an animal makes to any situation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Mice which carry mutant genes for neurologic defects or abnormalities.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
Morphological and physiological development of EMBRYOS or FETUSES.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
The degree of replication of the chromosome set in the karyotype.
The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Postmortem examination of the body.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Perinatal nephropathies. (1/804)

The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to limit the disposition of a fluid or solute load. Tubular reabsorption is also limited leading to the urinary loss of glucose, amino acids, bicarbonate and phosphate. Although the relatively low function of the immature kidney is a normal part of development, its capacity to respond under conditions of stress may be less adequate than in adults. An additional concern is that a variety of perinatal manipulations, such as the incidental or accidental ingestion of a chemical, may lead to varying degrees of altered morphogenesis or functional development of the kidney. Chemical induced renal anomalies may be of several types, but in typical teratology experiments hydronephrosis may be the most frequent observation. The functional consequences of these renal malformations may be lethal or inconsequential or while an animal may be able to survive and develop normally in the presence of a renal malformation, it is possible that a stressful situation would unmask a functional malformation which could compromise survival. Thus, some renal abnormalities may be subtle enough to go unnoticed without experimental tests. Without such tests it is impossible to evaluate the effect of functional alterations on successful adaptation.  (+info)

Developmental pathways: Sonic hedgehog-Patched-GLI. (2/804)

Developmental pathways are networks of genes that act coordinately to establish the body plan. Disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Environmental exposures can be associated with poor pregnancy outcomes, including dysmorphic offspring or children with a variety of diseases. An important goal of environmental science should be reduction of these poor outcomes. This will require an understanding of the genes affected by specific exposures and the consequence of alterations in these genes or their products, which in turn will require an understanding of the pathways critical in development. The ligand Sonic hedgehog, the receptors Patched and Smoothened, and the GLI family of transcription factors represent one such pathway. This pathway illustrates several operating principles important in the consideration of developmental consequences of environmental exposures to toxins.  (+info)

Young women taking isotretinoin still conceive. Role of physicians in preventing disaster. (3/804)

QUESTION: One of my adolescent patients was prescribed isotretinoin for severe acne by a dermatologist. I was shocked to discover she does not use any means of contraception. The dermatologist insists he told her about the need for contraception. How can we do better? ANSWER: Clearly this dermatologist, like many of his colleagues, does not comply with the Pregnancy Prevention Program. Until physicians become more aware of this program, babies will continue to be born with embryopathy due to isotretinoin.  (+info)

Embryonic and postnatal injections of bromodeoxyuridine produce age-dependent morphological and behavioral abnormalities. (4/804)

The mitotic marker 5-bromodeoxyuridine (BrdU) was injected twice daily (60 mg/kg) into pregnant hooded rats on one of embryonic days (E) 11, 12, 13, 15, 17, or 21, or into rat pups on postnatal day (P) 10. The principal findings were the following: (1) BrdU exposure on E11 produces profound effects on body morphology, and animals must be fed a special diet because of chronic tooth abnormalities; (2) BrdU exposure at E17 or earlier produces a change in coat spotting pattern, the precise pattern varying with age; (3) BrdU exposure on E15 or earlier produces a reduction in both brain and body weight; (4) BrdU exposure on E17 or earlier reduces cortical thickness; (5) BrdU exposure on E11-E13 and at P10 reduces cerebellar size relative to cerebral size; (6) spatial learning is significantly affected after injections of BrdU at E11-E17, but the largest effect is on E17; (7) the deficit in spatial learning may be related in part to a reduction in visual acuity; and (8) skilled forelimb ability is most disrupted after BrdU exposure at E15 but is also impaired after injections on E13 or earlier. BrdU thus has teratological effects on body, brain, and behavior that vary with the developmental age of the fetus or infant.  (+info)

Longitudinal limb deficiencies and the sclerotomes. An analysis of 378 dysmelic malformations induced by thalidomide. (5/804)

The pathogenesis of longitudinal reduction deformities of the limbs, or dysmelia, is still a matter of debate. Their morphological pattern was defined from a large collection of radiographs of children with dysmelia following the thalidomide disaster. We compared radiographs of 378 of these limbs with the sclerotomes which are areas of segmental sensory innervation of the limb skeleton defined by the radiation of referred pain. The pattern of dysmelia matched the sclerotomes closely in 279 limbs (73.5%). The principles of skeletal reduction in dysmelia are explained by the arrangement of the sclerotomes. The congruence between two separate and independent data sets shows that both patterns are expressions of the underlying segmental sensory innervation of the skeleton, and that the sensory nervous system is involved in the process of limb morphogenesis and teratogenesis.  (+info)

Pregnancy in patients after valve replacement. (6/804)

This report is based on information obtained from a questionnaire sent to major cardiac centres in the United Kingdom. This produced details of 39 pregnancies in 34 patients after valve replacement. The 39 pregnancies gave rise to 30 healthy babies. The small size of the series probably reflects both the increasing rarity of young women with rheumatic heart disease in this country and the cautious attitude of their cardiologists. This makes it likely that these women represented the best end of the spectrum of cardiac function after valve replacement. Twenty-four pregnancies in 20 women who were not given anticoagulants producted 23 healthy babies and 1 spontaneous abortion. This group comprised 6 patients with free aortic homografts, 1 patient with a fascia lata mitral valve, 1 with a Beall tricuspid prosthesis, 1 with a combined mitral homograft and Starr Edwards aortic prosthesis, and 1 with mitral and aortic frame-mounted fascia lata valves. There were no maternal deaths or thromboembolic complications in this group which included 5 patients who were in atrial fibrillation. Fifteen pregnancies in 14 women who received anticoagulants gave rise to 7 healthy babies. The fetal losses were one stillbirth, one intrauterine death at 34 weeks, and 3 spontaneous abortions; one surviving child has hydrocephalus as a result of blood clot and there were 2 maternal deaths. This group included 13 patients with Starr Edwards valves, 11 mitral and 2 aortic. A patient with a Hammersmith mitral valve was the only one to have been treated with heparin and her valve thrombosed. One patient with a mounted mitral homograft had a cerebral embolus. Nine of these patients were in atrial fibrillation. In 3 additional patients the valve replacement was carried out during pregnancy. Two of the patients survived operation. In one of these who was treated with warfarin the pregnancy well, but there is an increased fetal wastage in patients pregnancy gave rise to a congenitally malformed baby who died in the neonatal period. The baby born to the mother who did not receive anticoagulants has a hare-lip and talipes. Women with artificial valves can tolerate the haemodynamic load of pregnancy well, but there is an increased fetal wastage in patients taking oral anticoagulants. This is probably largely attributable to fetal haemorrhage but there is also a risk of malformation caused by a teratogenic effect of warfarin. Experience gained in non-pregnant patients suggests that withholding anticoagulatns in pregnant patients with prosthetic valves would usually be undersirable but warfarin should be avoided. The advantages of biological valves were apparent in this series.  (+info)

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. (7/804)

Previous experimental studies suggest that diabetic embryopathy is associated with an excess of radical oxygen species (ROS), as well as with a disturbance of prostaglandin (PG) metabolism. We aimed to investigate the relationship between these pathways and used hyperglycemia in vitro (embryo culture for 24-48 h) and maternal diabetes in vivo to affect embryonic development. Subsequently, we assessed lipid peroxidation and gene expression of cyclooxygenase (COX)-1 and -2 and measured the concentration of prostaglandin E2 (PGE2) in embryos and membranes. Both hyperglycemia in vitro and maternal diabetes in vivo caused embryonic dysmorphogenesis and increased embryonic levels of 8-epi-PGF2alpha, an indicator of lipid peroxidation. Addition of N-acetylcysteine (NAC) to the culture medium normalized the morphology and 8-epi-PGF2alpha concentration of the embryos exposed to high glucose. Neither hyperglycemia nor diabetes altered COX-1 expression, but embryonic COX-2 expression was diminished on gestational day 10. The PGE2 concentration of day 10 embryos and membranes was decreased after exposure to high glucose in vitro or diabetes in vivo. In vitro addition of NAC to high glucose cultures largely rectified morphology and restored PGE2 concentration, but without normalizing the COX-2 expression in embryos and membranes. Hyperglycemia/diabetes-induced downregulation of embryonic COX-2 gene expression may be a primary event in diabetic embryopathy, leading to lowered PGE2 levels and dysmorphogenesis. Antioxidant treatment does not prevent the decrease in COX-2 mRNA levels but restores PGE2 concentrations, suggesting that diabetes-induced oxidative stress aggravates the loss of COX-2 activity. This may explain in part the antiteratogenic effect of antioxidant treatment.  (+info)

Scanning electron microscopy of lithium-induced exogastrulae of Xenopus laevis. (8/804)

Lithium-induced exogastrulae are abnormal embryos which fail to complete gastrulation and do not form normal neural structures. Scanning electron microscopy has been used to compare the surface structure of the ectoderm cells of exogastrulae with that of the ectoderm cells of normal embryos and has shown that the appearance of ciliated cells is delayed in exogastrulae. In addition, the structure of endoderm cells, which remain exposed in these embryos, has been studied.  (+info)

See ACOGs Practice Advisory for guidance regarding reporting to the US Zika Pregnancy Registry.. The US Zika Pregnancy Registry has been established to track Zika virus infections that occur in pregnant women and the outcomes of those pregnancies. Obstetrician-gynecologists should report pregnant women with any laboratory evidence of Zika virus infection (positive or inconclusive test results) as well as any adverse outcomes to their state health department.. To better facilitate reporting, the CDC has provided a contact list of US Zika Pregnancy Registry contacts for each state (ACOG members only).. CDC Zika Pregnancy Hotline for Healthcare Providers ...
Xing, Jiangwa, Toh, Yichin, Xu, Shuoyu, Yu, Hanry (2015). A method for human teratogen detection by geometrically confined cell differentiation and migration. Scientific Reports 5. [email protected] Repository. https://doi.org/10.1038/ ...
The Registry is designed for open enrollment of all patients who meet the inclusion criteria. The function and activities of the Nuvigil/Provigil Pregnancy Registry will be publicized through direct mailings to obstetricians and pharmacists. Known prescribers identified from marketing sources will be targeted for Registry awareness. A toll-free phone line will be established for patient enrollment and a website containing information about the Registry for both physician and patient recruitment will be available. The Registry will be posted on the FDA website for pregnancy registries, with a direct link to a Nuvigil/Provigil Registry website. For ongoing awareness, information on the Registry will be included in the prescribing information and in the Medication Guides distributed by the pharmacist at the time of dispensing. In addition, patient support groups or condition-related sources of information may be targeted to raise patient awareness of the Registry ...
If you are interested in the MotHER Pregnancy Registry, call 1-800-690-6720 (Mon-Fri, 8:30 AM-6 PM EST). You can also contact us by email. Learn more.
PubMed journal article: Developmental toxicity study of pure trans-capsaicin in rats and rabbits. Download Prime PubMed App to iPhone, iPad, or Android
Caroline L. Tait National Network for Aboriginal Mental Health Research Alcohol-Related Birth Effects and Aboriginal Peoples: Prevention, Identification and Intervention Services This presentation examines
Not enough is known about the effects of medicines such as Herceptin®, PERJETA®, or KADCYLA® on pregnant women with breast cancer. Help answer these questions.
Samren, E.B.; Duijn, C.M. van; Koch, S. ; Hillesmaa, V.K.; Klepel, H.; Bardy, A.H.; Beck Mannagetta, G.; Deichi, A.W.; Gaily, E.; Granström, M.L.; Meinardi, H.; Grobbee, D.E.; Hofman, A.W.I.M.; Janz, D.; Lindhout, D. ...
The purpose of the Multi-National Gilenya Pregnancy Exposure Registry in Multiple Sclerosis (MS) is to continuously monitor, evaluate, and assess for major and minor teratogenic effects in the offspring of women exposed to Gilenya before (up to 8 weeks before last menstrual period) and during pregnancy in routine clinical practice. The overall aim is to collect and evaluate data on maternal, fetal, and infant outcomes and compare it with reference populations ...
Experience is limited with the use of Baraclude in pregnant women. Therefore, it should not be used during pregnancy unless it is clearly needed. If there is an urgent need to consider Baraclude during pregnancy, your doctor will discuss with you the benefits and risks of taking it. If you take Baraclude while you are pregnant, talk to your doctor about how you can take part in the Baraclude Pregnancy Registry. The purpose of the pregnancy registry is to collect information about the health of you and your baby ...
FDA thinks its important for the health of both a pregnant mother and her fetus to learn about a drug?s adverse effects: but is it?
Restricted scientific info are available in the Humira Pregnancy Registry. Excluding misplaced-tofollow- up, details within the registry reviews a level of five.six% for important birth defects with very first trimester use of adalimumab in Expecting Girls with rheumatoid arthritis (RA), as well as a fee of seven.8% and five.five% for key birth defects inside the disease-matched and non-diseased comparison teams [see Details]. Adalimumab is actively transferred over the placenta through the third trimester of pregnancy and should influence immune reaction inside the in-utero uncovered toddler [see Medical Things to consider ...
Are a woman who could become pregnant, or may be pregnant. HERCEPTIN may result in the death of an unborn baby or birth defects. Contraception should be used while receiving HERCEPTIN and after your last dose of HERCEPTIN. If you are exposed to HERCEPTIN during pregnancy or within 7 months of becoming pregnant, you are encouraged to enroll in the MotHER Pregnancy Registry by contacting 1-800-690-6720 or visiting http://www.motherpregnancyregistry.com/ and report HERCEPTIN exposure to Genentech at 1-888-835-2555. ...
List pre-pregnancy guidelines for transplant recipients and review the pregnancy outcomes from the Transplant Pregnancy Registry International ...
TY - JOUR. T1 - Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice. AU - Wang, Rui Sheng. AU - Ohtani, Katsumi. AU - Suda, Megumi. AU - Kitagawa, Kyoko. AU - Nakayama, Keiichi. AU - Kawamoto, Toshihiro. AU - Nakajima, Tamie. PY - 2007/8/1. Y1 - 2007/8/1. N2 - Ethylene glycol monoethyl ether (EGEE) can cause damage to testes and sperm, and its metabolites are believed to play an important role in its toxicity. Aldehyde dehydrogenase 2 (ALDH2) is involved in the metabolism of this chemical. To investigate whether and how the enzyme affects the toxicity of EGEE, we conducted experiments comparing Aldh2 knockout mice with wild-type mice. Administration of EGEE at 100 and 600 mg/kg/day for one week did not induce any significant change in the weight and body weight ratios of testes, prostate and epididymides in either Aldh2 knockout or wild-type mice. However, motion of sperm from the spermaduct, as analyzed with a Hamilton-Thorne Sperm analyzer, was slightly decreased in ...
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Alcohol-Related Birth Defects (ARBD)/Fetal alcohol syndrome is one of a spectrum of disorders under the umbrella term of fetal alcohol spectrum disord
The global diethylene glycol monoethyl ether market size was estimated at USD 374.9 million in 2018 and is expected to witness a CAGR of 5.3% from 2019 to 2025. The consumption of DEGEE is dominated by its application in floor polish and paints, coatings, and inks owing to its superior properties as a solvent
To test the hypothesis that children born to mothers living near the sea are at increased risk of limb reduction defects. Descriptive data analysis. The northern health region of England. All children born between 1 January 1985 and 31 December 1992 in the northern region of England with isolated limb reduction defects. The birth prevalence of isolated limb reduction defects was not affected by the distance the mother lived from the sea. There was some evidence of space-time clustering, but there was no evidence of statistically significant variation in the occurrence of the condition with sex, time of birth (monthly or yearly), or county of birth. There is no evidence that children born to mothers living near the sea are at increased risk of limb reduction defects.. ...
Other names: «beta»-Ethoxyethanol; Cellosolve; Emkanol; Ethyl cellosolve; Ethylene glycol ethyl ether; Ethylene glycol monoethyl ether; Glycol monoethyl ether; Oxitol; Plastiazan 60; Poly-Solv EE; 2-Ethoxyethanol; HOCH2CH2OC2H5; Cellosolve solvent; 2-Ethoxyethyl alcohol; Ethyl-2-hydroxyethyl ether; Dowanol EE; Ether monoethylique de lethylene-glycol; Ethyl glycol; Ethylethylene glycol; Etoksyetylowy alkohol; Glycol ethyl ether; Hydroxy ether; NCI-C54853; 2EE; EE solvent; EGEE; Ektasolve EE; Ethoxyethanol; Ethyl icinol; Glycol ether EE; Jeffersol EE; Bikanol E 1; NSC 8837; Solvid; 2-ethoxyethanol (cellosolve ...
(R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source of ketones, which may be utilized for energy. In a 28-day toxicity study, Crl:WI (Wistar) rats received diets containing, as 30% of the calories, ketone monoester (12 and 15 g/kg body weight/day for male and female rats, respectively). Control groups received either carbohydrate- or fat-based diets. Rats in the test group consumed less feed and gained less weight than control animals; similar findings have been documented in studies of ketogenic diets. Between-group differences were noted in selected hematology, coagulation, and serum chemistry parameters; however, values were within normal physiological ranges and/or were not accompanied by other changes indicative of toxicity. Upon gross and microscopic evaluation, there were no findings associated with the ketone monoester. In a developmental toxicity study, pregnant Crl:WI (Han) rats were administered 2g/kg body weight/day ketone monoester or water
Q00-Q99 - Congenital malformations of the circulatory system; Congenital malformations of the respiratory system; Cleft lip and cleft palate; Other congenital malformations of the digestive system; Congenital malformations of genital organs; Congenital malformations of the urinary system; Congenital malformations and deformations of the musculoskeletal system; Other congenital malformations; Chromosomal abnormalities, not elsewhere classified: Diseases and Medical Conditions (ICD-10) from Drugs-about.com
Mr. Speaker, I am pleased to rise to speak to the concurrence motion, the effect of which is to ask Health Canada to table with the House a comprehensive strategy to address fetal alcohol spectrum disorders. I very much support it and I will do as much as I can to ensure that other members in the House support the initiative. It is very important and it is time.. Let me talk very briefly about fetal alcohol spectrum disorders. Maternal consumption of alcohol during pregnancy is the leading known cause of mental retardation in Canada. As was indicated earlier, about one out of every 100 live births results in a birth defect. That means, and testimony has said, that up to 5,000 children each year will suffer from alcohol-related birth defects. It is very important that we understand the enormity of this and the attendant costs.. Here are a few of the secondary symptoms associated with FASD. Sixty per cent of these children will drop out of school or be suspended. Sixty per cent will get into ...
Data from the UK Epilepsy and Pregnancy Registry has shown that almost 96 per cent of babies born to women with epilepsy do not have a major congenital malformation (J Neurol Neurosurg Psychiatry 2006; 77: 193-8). The most effective drug should be chosen before conception and prescribed at its lowest dosage, ideally as monotherapy ...
Enrolling your patients in a pregnancy exposure registry can help improve safety information for medicines used during pregnancy and can be used to update drug labeling.
Isotretinoin (Accutane) is classified as a pregnancy category X drug, meaning it is a proven human teratogen or contains chemicals that are known to induce birth defects. The FDA has stringent guidelines regarding the use of this medication. ...
Abstract The antiepileptic drug Valproic acid (Val) is a known human teratogen. The risk is dose dependent and when the daily doses in pregnancy exceed 1400 mg up to 15% may be affected. The main clinical findings of the ...
In view of the great number of teratogenic factors known and the vast array of congenital defects, disorders and syndromes, it would probably be a waste of time to search for unifying mechanisms and principles in abnormal development. Instead, therefore, I shall describe a selection of teratogens and their consequences, and try to arrange them in a certain hierarchy based on a simplified model of how they act.. The assumption underlying the model (Figs. 1 and 2) is that the result of a teratogenic insult is determined by its site of action and the stage of development of the target organ. This is supposed to hold for all congenital defects, whether due to genes or caused by exogenous agents. In genetic defects the scheme indicates the site and stage of development at which the mutant gene is expressed; in nongenetic defects the site and stage refer to exposure to an exogenous teratogen.. ...
Degenhardt, K; Franz, J; and Yamamura, H, A model in comparative teratogenesis, dose response to 5-fluoro-2- -deoxycytidine (fcdr, ro 5-1090) in organogenesis of mice of strains c57bl/6jhanffm and c57bl/10jffm. (1968). Subject Strain Bibliography 1968. 1436 ...
Developmental toxicity The appropriate read-across candidate of delta-damascone, alpha-iso-methylionone (EC name:3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one) was tested in an oral (gavage) developmental toxicity study with rats (Charles River, 2005) One hundred pregnant Crl: CD®(SD) IGS BR VAF/Plus® rats were randomly assigned to four dosage groups, 25 rats per group. The test article, alpha-iso-methylionone, and/or the vehicle, corn oil, was administered to the rats orally (gavage) once daily on days 7 through 17 of presumed gestation (gestation days (GD) 7 through 17) at dosages of 0, 3, 10 and 30 mg/kg bw/day. The dosage volume was 10 mL/kg, based on individual body weights recorded daily before administration. Viabilities, clinical observations, body weights and feed consumption values were recorded. All rats were sacrificed on GD 21, Caesarean-sectioned and examined for the number and distribution of corpora lutea, implantation sites and uterine contents. A gross necropsy ...
Animal studies have revealed no evidence of teratogenicity or fertility impairment, but adverse effects including incomplete fetal skeletal ossification
There are currently no experimental data available to assess developmental toxicity / teratogenicity for the magnesium hydrogenorthophosphate. For the structural similar substance calcium dihydrogenorthophosphate monohydrate (CAS 10031 -30 -8) three studies are available which were done before guidelines were available (Morgareidge, 1974). These studies were conducted similar to OECD 414 in three different species - mice, rats and rabbits. Although the report is not as detailed as required according to todays standards these three studies are considered reliable in order to assess the developmental toxicity of calcium dihydrogenorthophosphate monohydrate. A reason for the dosage levels are not given which in fact are considered too low since no maternal toxicity was observed. But since the tests were conducted in three different species and in none of these studies developmental effects were observed these studies are considered as reliable on the basis of weight of evidence. Mice: Adult female ...
We are pioneering efforts to reduce birth defects through our innovative research endeavors. If you are new to this field, you may wonder what are birth defects? While still in the womb some babies have problems with how their organs and body parts form or, once formed, how they work. These are called birth defects.. There are more than 4,000 different kinds of birth defects, ranging from minor to major. Birth defects can occur at any stage of pregnancy. Some birth defects are inherited, some are caused by exposure to a harmful product in the environment (called a teratogen), and some are caused by a complex interaction of both genetic make-up and environment. But in about 50% of birth defects, the cause is unknown.. Heres what were doing to better understand the causes of birth defects, so we can better prevent and treat them.. ...
Animal Data The potential embryo-fetal toxicity of rolapitant was assessed in pregnant rats administered oral doses up to 22.5 mg/kg per day throughout the period of organogenesis. Rats administered doses of 13.5 or 22.5 mg/kg per day rolapitant exhibited evidence of maternal toxicity including decreased body weight gain and/or body weight loss and a concomitant decrease in food consumption during the first week of dosing. No adverse embryo-fetal developmental effects were observed at doses up to 22.5 mg/kg per day rolapitant (approximately 1.2 times the recommended human dose on a body surface area basis). In rabbits administered rolapitant throughout the period of organogenesis, oral doses up to 27 mg/kg per day (approximately 2.9 times the recommended human dose on a body surface area basis) were without effects on the developing fetus. The pre- and postnatal developmental effects of rolapitant were assessed in rats administered oral doses of 2.25, 9 or 22.5 mg/kg per day during the periods ...
Experimental Studies on Congenital Malformations (1959), by James G. Wilson The article Experimental Studies on Congenital Malformations was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson, studied embryos and birth defects
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system
ICD-10-CM - Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities - Q00-Q07 Congenital malformations of the nervous system - Q07.9
Are a woman who could become pregnant, or may be pregnant. HERCEPTIN may result in the death of an unborn baby or birth defects. Contraception should be used while receiving HERCEPTIN and after your last dose of HERCEPTIN. If you are exposed to HERCEPTIN during pregnancy or within 7 months of becoming pregnant, you are encouraged to enroll in the MotHER Pregnancy Registry by contacting 1-800-690-6720 or visiting http://www.motherpregnancyregistry.com/ and report HERCEPTIN exposure to Genentech at 1-888-835-2555. ...
CDC Split Type: (blank) waes0705usa03252. Write-up:Information has been received from a physicians physicians assistant through the Merck Pregnancy registry concerning a 15 year old female patient with asthma who on 16-JAN-2007, was vaccinated IM with a second dose of Gardasil (Lot# 655617/1447F). Concomitant therapy therapy included albuterol MDI. After the second dose, it was discovered that she was pregnant. No adverse events were noted. On 24-MAY-2007, the patient elected to terminate the pregnancy. The patient was 21 weeks from last menstrual period. On 20-MAY-2007 and 22-MAY-2007, an ultrasound was performed and the results were unknown. At the time of this report, the patients outcome was unknown. It was also reported on 16-NOV-2006, the patient was vaccinated with a first dose of Gardasil (Lot# 653736/0868F). No product quality complaint was involved. Upon internal review, elective termination was considered to be an other important medical event. Additional information is not ...
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Despite study limitations, results suggest that duloxetine does not appear to increase the rate of major malformations above baseline.
Metamorphic Congenital Malformation lyrics by Cephalotripsy: Scourging paths of the impermissible / Descending upon dwellings of those
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This page was last edited 05:31, 3 May 2008 by [email protected] Based on work by wikidoc anonymous users Lisatwo and Arcadian ...
[150 Pages Report] Check for Discount on 2016 Propylene Glycol MonoEthyl Ether (CAS 52125-53-8) Industry Market Report report by Prof Research. The Global and Chinese Propylene Glycol MonoEthyl Ether Industry, 2011-...
QY Research Reports described a depth and professional market study and forecast trends on Global and China Dipropylene Glycol Monoethyl Ether (DPE) Industry Research Report 2013. This report also includes more info about basic overview of the industry including definitions, applications and industry china structure.. ...
TY - JOUR. T1 - Bayesian semiparametric analysis of developmental toxicology data. AU - Dominici, Francesca. AU - Parmigiani, Giovanni. PY - 2001. Y1 - 2001. N2 - Modeling of developmental toxicity studies often requires simple parametric analyses of the dose-response relationship between exposure and probability of a birth defect but poses challenges because of nonstandard distributions of birth defects for a fixed level of exposure. This article is motivated by two such experiments in which the distribution of the outcome variable is challenging to both the standard logistic model with binomial response and its parametric multistage elaborations. We approach our analysis using a Bayesian semiparametric model that we tailored specifically to developmental toxicology studies. It combines parametric dose-response relationships with a flexible nonparametric specification of the distribution of the response, obtained via a product of Dirichlet process mixtures approach (PDPM). Our formulation ...
Values obtained for specific surface area depend on the method of measurement. In adsorption based methods, the size of the adsorbate molecule (the probe molecule), the exposed crystallographic planes at the surface and measurement temperature all affect the obtained specific surface area.[4] For this reason, in addition to the most commonly used Brunauer-Emmett-Teller (N2-BET) adsorption method, several techniques have been developed to measure the specific surface area of particulate materials at ambient temperatures and at controllable scales, including methylene blue (MB) staining, ethylene glycol monoethyl ether (EGME) adsorption,[5] electrokinetic analysis of complex-ion adsorption[4] and a Protein Retention (PR) method.[6]. ...
This page includes the following topics and synonyms: Fetal Alcohol Syndrome, Fetal Alcohol Effect, Fetal Alcohol Spectrum Disorders, Partial Fetal Alcohol Syndrome, Alcohol-Related Neurodevelopmental Disorder, Alcohol-Related Birth Defect.
This page includes the following topics and synonyms: Fetal Alcohol Syndrome, Fetal Alcohol Effect, Fetal Alcohol Spectrum Disorders, Partial Fetal Alcohol Syndrome, Alcohol-Related Neurodevelopmental Disorder, Alcohol-Related Birth Defect.
The foetal outcomes of 2,635 pregnancies recorded in the Australian Pregnancy Register were studied. In at least the initial 4 months of 515 pregnancies, there had been no intrauterine exposure to antiepileptic drugs, though the women involved in 264 of these pregnancies took antiepileptic drugs in later pregnancies. Compared with these 515 drug-unexposed pregnancies, foetal malformations risks were increased more than five-fold in association with valproate monotherapy, and more than doubled in association with carbamazepine monotherapy (p , 0.05). There were no statistically significant increases in malformation rates associated with other more commonly used antiepileptic drugs, while the malformation risk in relation to levetiracetam exposure was lower than that in the drug-unexposed pregnancies. The published literature has rather consistently shown raised malformation rates associated with carbamazepine monotherapy, though only once was it statistically significant. There now appears to be ...
The projects underway include studies of the fetal effects of anticonvulsant drugs taken by pregnant women. One major activity is the North American AED (antiepileptic drug) Pregnancy Registry, which was established in 1997. Over 8,000 women in the United States and Canada have enrolled while pregnant. The apparent safety of over 30 different anticonvulsant drugs is being evaluated. Several significant new findings have been reported.. Another major project is the study of the causes of malformations identified in newborn infants at Brigham and Womens Hospital. The Active Malformations Surveillance Program began in 1972 and has identified over 250,000 affected newborn infants. The apparent causes have been analyzed and tabulated and show a high degree of heterogeneity. This project is supported by funds provided by the National Birth Defects Prevention Study, which is coordinated by the Birth Defects Center at the Centers for Disease Control.. ...
Amelia of Upper Limb (Limb Reduction Defect): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Muscle Beach looks like an old film set or something, a courtyard with empty garages and buildings encircling it. The Beach is set back in one of these. We rolled up right when VBS were getting there and some noise dude was setting up. We took seats on some old couches and I broke open the flask of Knobb Creek I brought along (heard Muscle Beach doesnt have a bathroom, so I didnt wanna fill up). The vibe definitely seemed more Jeff the Pigeon than Jans Room. First noiser dude (not sure who it was) had a chaotic rumble going on, but when he started vocalizing, it interrupted the black cloud I was digging. After he finished up, wound up blabbing with Dan from VBS about Lux-era Temple of Bon Matin and such, everyone was buzzing and babbling, thanks for the new CD, dude. After I mooched a Schaeffers from him, VBSs other guitar player put a few drops of some w33dy-grain alcohol concoction in it. I was kinda like, yeah right, but why not ...
4.5 Interaction with other medicinal products and other forms of interaction Laxatives. There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetam. Therefore, macrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.. 4.6 Fertility, pregnancy and lactation Pregnancy. Postmarketing data from several prospective pregnancy registries have documented outcomes in over 1000 women exposed to levetiracetam monotherapy during the first trimester of pregnancy. Overall, these data do not suggest a substantial increase in the risk for major congenital malformations, although a teratogenic risk cannot be completely excluded. Therapy with multiple antiepileptic medicinal products is associated with a higher risk of congenital malformations than monotherapy and therefore monotherapy should be considered. Studies in animals have shown reproductive toxicity (see ...
The French Perinatal Cohort reported an association of head and neck birth defects with first-trimester exposure to didanosine (0.5%, AOR = 3.4 (95% CI, 1.1-10.4), P = 0.04).4 Though the PHACS/SMARTT cohort found no association between any individual NRTIs and birth defects, after adjusting for birth cohort and other factors, didanosine in combination with stavudine was associated with an overall increase in congenital abnormalities;5 it should be noted that the combination of didanosine and stavudine should no longer be used in pregnant women with HIV (or anyone with HIV) because of higher risk of toxicity. Among 897 births to women with HIV in a Spanish cohort, there was no significant difference in the rate of birth defects between first-trimester compared to the second- and third-trimester exposure (OR 0.61, 95% CI, 0.16-2.27).6 In the Antiretroviral Pregnancy Registry, sufficient numbers of first-trimester exposures to didanosine in humans have been monitored to be able to detect at least a ...
Special thanks to Elise Lewis for taking time out of her busy schedule at SOT to make sure things were running smoothly in the booth throughout the event. In addition, Alan Hoberman, Vice President, shared Teratology Society information and co-presented the Edward W. Carney Trainee Award with Chris Bowman, RDTSS President, at the SOT Reproductive and Developmental Toxicology Specialty Section Reception on Tuesday evening.. Thank you all for serving as ambassadors of the Teratology Society this week in Baltimore! ...
TY - JOUR. T1 - Perspectives of primary care clinicians on teratogenic risk counseling. AU - Schwarz, Eleanor. AU - Santucci, Aimee. AU - Borrero, Sonya. AU - Akers, Aletha Y.. AU - Nikolajski, Cara. AU - Gold, Melanie A.. PY - 2009/10/1. Y1 - 2009/10/1. N2 - BACKGROUND: Women of childbearing age are commonly prescribed medications by primary care providers (PCPs) that may cause birth defects if used during pregnancy. METHODS: To identify what PCPs perceive as barriers to and potential facilitators of providing counseling to women of childbearing age when teratogenic medications are prescribed, we conducted eight focus groups with 48 PCPs recruited from four clinical settings in Pittsburgh, Pennsylvania. We explored PCPs experiences counseling women about teratogenic medications. Each focus group was audio-recorded, transcribed, and coded using a grounded theory approach by three independent coders. RESULTS: PCPs feel responsible for counseling women when they prescribe medications that may ...
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A gift to NOFAS will help raise awareness about the risk of alcohol use during pregnancy and prevent alcohol-related birth defects, and will support individuals and families living with FASD. You will be helping to build a network of resources and improving outcomes for both children and adults ...
In the rat embryo/fetal developmental toxicity study, pregnant rats received daily oral doses of mirabegron at 0, 10, 30, 100, or 300 mg/kg from implantation to closure of the fetal hard palate (7th to 17th day of gestation). Maternal systemic exposures were approximately 0, 1, 6, 22, or 96 times greater than exposures in women treated at the MRHD of 50 mg based on AUC. No embryo/fetal toxicities were observed in rats exposed up to 6 times the human systemic exposure at the MRHD of 50 mg. At systemic exposures equal to or greater than 22 times the human systemic exposure at the MRHD, delayed ossification and wavy ribs were observed in fetuses at an increased incidence. These findings were reversible.. In the rabbit embryo/fetal developmental toxicity study, pregnant rabbits received daily oral doses of mirabegron at 0, 3, 10, or 30 mg/kg from implantation to closure of the fetal hard palate (6th to 20th day of gestation). Maternal systemic exposures were 0, 1, 14, or 36 times that in women ...
Rogers JM. Rogers J.M. Rogers, John M.Developmental Toxicology. In: Klaassen CD, Watkins III JB. Klaassen C.D., & Watkins III J.B.(Eds.),Eds. Curtis D. Klaassen, and John B. Watkins III.eds. Casarett & Doulls Essentials of Toxicology, 3e. McGraw-Hill; Accessed October 24, 2020. https://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=1541§ionid=92520192 ...
Running Head: TERATOGENS DURING PREGNANCY Teratogens During Pregnancy Nicole Carter PSY 2103 - Human Development Mary Wilson November 9, 2010 | Teratogens
After adjusting for potential confounders, clindamycin exposure was associated with an increased risk of MCMs (aOR 1.34, 95%CI, 1.02-1.77, 60 exposed cases), musculoskeletal system malformations (aOR 1.67, 95%CI, 1.12-2.48, 29 exposed cases) and ventricular/atrial septal defect (aOR 1.81, 95%CI, 1.04-3.16, 13 exposed cases).. Doxycycline exposure increased the risk of circulatory system malformation, cardiac malformations and ventricular/atrial septal defect (aOR 2.38, 95%CI ,1.21-4.67, 9 exposed cases; aOR 2.46, 95%CI, 1.21-4.99, 8 exposed cases; aOR 3.19, 95%CI, 1.57-6.48, 8 exposed cases, respectively). Additional associations were seen with quinolone (1 defect), moxifloxacin (1 defect), ofloxacin (1 defect), macrolide (1 defect), erythromycin (1 defect) and phenoxymethylpenicillin (1 defect). No link was observed with amoxicillin, cephalosporins and nitrofurantoin. Similar results were found when penicillins were used as the comparator group.. Conclusions. ...
Enrolment should take place as early in the pregnancy as possible and prior to any knowledge of the pregnancy outcome. Healthcare providers and pregnant women are encouraged to notify GSK Safety Department of any pregnancies where exposure to mepolizumab has occurred and the pregnancy outcome is already known. An Eligible pregnant woman may self-enrol at any time during their pregnancy or, with their consent, their HCP may enrol them on their behalf. Contact Information: The study is conducted on behalf of GSK by:. The Organization of Teratology Information Specialists (OTIS) Research Center. University of California. La Jolla. San Diego. California. USA. Telephone: 877.311.8972. Email: [email protected] For more information, visit the MotherToBaby Website: http://www.mothertobaby.org/refer. Enrolment. Target Enrolment: ...
All pregnant women ages 18-45 are eligible to enroll in the registry. We are currently seeking both controls and those being treated with atypical antipsychotics and/ or antidepressants.. This study will involve 3 brief phone interviews over an 8-month period. The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications that may be taken by women during pregnancy to treat a wide range of mood, anxiety, or psychiatric disorders. The primary goal of this Registry is to determine the frequency of major malformations, such as heart defects, cleft lip, or neural tube defects, in infants exposed to atypical antipsychotics and antidepressants during pregnancy. For more information, please call 1-866-961-2388 or e-mail [email protected] Help make the future better for many other women like you ...
The use of behavioral changes as an indicator of teratogenic potential is evaluated. Testing procedures involving central nervous system activity or task specific responses are discussed along the effects of drug metabolism on behavioral response. Preliminary results of a behavioral teratology study of methylene- chloride (75092) in Long-Evans-rats are included. The author concludes that behaviora
Many herbs used for these purposes are believed to be teratogens, substances that cause the development of abnormal structures in the embryo. Usually teratogens in a womans system during the first two weeks of pregnancy (from conception) will cause the pregnancy to terminate. To help you understand why this is, Ive added a section on the day to day development of the fertilized egg with pictures ...
Two-dimensional echocardiography showed no cardiac abnormality. An ultrasound scan of the abdomen was also normal. A radiograph of the dorsolumbar spine revealed an unfused spinous process of the L5 vertebra. A radiograph of the skull was normal. In view of the history of maternal intake of VPA during pregnancy and the typical dysmorphic features, a diagnosis of FVS was made.. Discussion. None of the currently available AEDs are completely safe during pregnancy, but VPA appears to be the most teratogenic. In approximately 1 in 250 pregnancies the fetus is known to be exposed to AEDs, and a significant proportion ofthese are exposed to VPA.[2] The overall risk of major congenital malformation (MCM) in patients receiving AEDs during pregnancy is 4.2%. The MCM rate is higher for polytherapy than for monotherapy, and polytherapy regimens containing valproate result in significantly more MCMs than those not containing valproate. For monotherapy exposure, valproate has a higher MCM rate than any other ...
Congenital Malformations of the Head and Neck offers a unique conceptual and visual approach to children with congenital malformations of the head and neck Developed by renowned leaders in the field, this title is richly illustrated with a wealth of patient photos, radiology and endoscopic images of malformations Starting with the genetics of common congenital syndromes, Congenital Malformations of the Head and Neck goes on to comprehensively cover malformations of the ear, nose, nasopharynx, oral cavity, oropharynx, cleft lip and palate, larynx, trachea, and neck �Easy-to-read and an indispensable reference and teaching resource, this title will serve as an invaluable reference for clinicians, neurologists, pediatricians, otolaryngologists and head and neck surgeons It should also be of great interest to fellows and residents � ...
There are things in this world which you should avoid if you are planning a pregnancy. A teratogen is a substance or condition which can cause a birth defect. There are relatively few, known teratogens. Not all birth defects are…. Read more →. ...
Abstract: n 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:Table Normal; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Times New Roman,serif;} Background: Alprazolam belongs to benzodiazepine family and is increasingly used these days by pregnant women. It should be noticed that alprazolam exposure during pregnancy may have teratogenic effects on the fetus. Till now, limited studies have been conducted on the teratogenic effect of alprazolam. In this study, teratogenicity of alprazolam intake during pregnancy and its effects on fetus development was investigated. nnMethods: About 20 virgin rats of known age and weight were selected. After being pregnant, they were divided ...
It is wise to avoid most herbs and medications completely in the first trimester of pregnancy, if possible. It is during the first trimester that teratogenic effects - the negative result of consuming a harmful substance that affects the baby - are most common. Some teratogenic effects are fetal alcohol syndrome, birth defects, and mental retardation. It is important to seek guidance from a qualified herbalist or holistic provider before taking herbs during pregnancy to determine the safest herb and dosage for mom and baby. In general, you should avoid medicinal amounts of herbs during pregnancy, without first consulting with an herbalist or holistic provider trained in their use. It is also important to avoid large amounts of alcohol tinctures, and to make sure that any herbs you use are high quality and free of adulteration or contamination.. ...
In a key pre-natal developmental toxicity study, the test material (Rosin, CAS# 8050-09-7) was administered by continuous dietary admixture to three groups each composed of twenty-four time mated Sprague-Dawley Crl:CD®(SD) IGS BR strain rats, between gestation days 3 and 19 (inclusive) at dietary concentrations of 2500, 5000, or 7500 ppm (equivalent to mean achieved dosages of 199.3, 387.2 or 561.1 mg/kg bw/day respectively). A further group of twenty-four time mated females was fed basal laboratory diet to serve as a control. Clinical signs, body weight change, food and water consumptions were monitored during the study. All females were terminated on gestation day 20 and subjected to gross necropsy including examination of the uterine contents. The number of corpora lutea, number, position and type of implantation, placental weights, foetal weight, sex and external and internal macroscopic appearance were recorded. Half of the pups from each litter were examined for detailed skeletal ...
Ledipasvir: Ledipasvir was administered orally to pregnant rats (approximately 100 mg/kg/day) and rabbits (up to 180 mg/kg/day) on gestation days 6 to 18 and 7 to 20, respectively, and also to rats (oral doses up to 100 mg/kg/day) on gestation day 6 to lactation/post-partum day 20.. No substantial results on embryo-fetal (rats and bunnies) or pre/postnatal (rats) development were observed at the greatest dosages checked. Systemic exposures (AUC) to ledipasvir were ≥ 4 (rats) and 2 (bunnies) times the direct exposure in human beings at the RHD.. Sofosbuvir: Sofosbuvir was administered orally to pregnant rats (approximately 500 mg/kg/day) and rabbits (approximately 300 mg/kg/day) on pregnancy days 6 to 18 and 6 to 19, respectively, as well as to rats (oral doses up to 500 mg/kg/day) on gestation day 6 to lactation/post-partum day 20.. No significant results on embryo-fetal (rats and bunnies) or pre/postnatal (rats) development were observed at the highest dosages checked. Systemic exposures ...
Animal studies can, but do not always, predict whether a drug will be teratogenic in humans. The main role of animal studies is to help researchers understand the mechanisms of teratogenicity. Unfortunately, animal studies were poor predictors in the case of thalidomide; the drug was tested on rats and mice, but did not originally produce birth defects.1 On the other hand, some drugs have been found teratogenic in animals and not in humans.2,3 Today, when new drugs are screened for teratogenicity, three different animal models are required for testing. Quite frequently, when certain drugs are tested on different animal species, birth defects occur, as happened in the DM study.4 Interspecies differences regarding the teratogenicity of drugs can result from differing pharmacokinetic processes that determine the crucial concentration-time relationships in an embryo. Protein binding in the mother is also an important determinant of placental transfer because only free concentrates in maternal plasma ...
Assessment of the developmental toxicity and placental transfer of 1,2-dichloroethane in rats.: This study evaluates the developmental toxicity and placental tr
A simple and informative look at teratogens that may cause birth defects. CBNS 169. **EDIT: NEW VERSION, NOW WITH LEGAL AUDIO** old, original version, muted version available on my videos.. ...
These data from the Strasbourg Prospective Study of Congenital Malformations are reported in Congenital Malformations Worldwide: A Report from the International Clearinghouse for Birth Defects Monitoring Systems.. ...
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Teratogen is a simple roguelike for testing the Go programming languages suitability for game development. Currently only works on Linux. Note from author: As of 2010-11, the project is on permanent hiatus. Google dropped the exp/iterable module from Go, which the Teratogen code uses extensively for its internal logic. Code will need either a rewrite or copying the old exp/iterable code into the internal source tree to be compilable with a current version .of Go. The current Go language, still without generics, is a bit too hostile to abstraction in algorithm code for me to bother. I might get back to it when they get a generics implementation out. ...
A few months losartan and fetal toxicity Apple Watch features include a heart rate monitor, gyro, NFC, GPS, Handoff and the proprietary OS that is supposed to rival Android Wear
The anticoagulant ( blood thinner ) Coumadin is a known teratogen, an agent that can disturb the development of the embryo and fetus and lead to birth defects.. Coumadin taken by a woman during pregnancy can cause bleeding into the baby s brain…
"Severe and unrecognized dental abnormalities after drug-induced epidermal necrolysis". Archives of Dermatology. 145 (11): 1332- ... Thalidomide (N-phthaloylglutamine) was also discovered to have a causative effect on mothers who took the drug during pregnancy ... Exposure to PCBs (such as dioxin), allergies, and toxic epidermal necrolysis folloeing a drug reaction may also be contributing ... It usually occurs as part of a syndrome that involves other abnormalities and requires multidisciplinary treatment. The ...
Drug-induced nail changes are caused by drug usage which may result in various abnormalities.: 665-6 In approximately half of ... Nail Abnormalities: Clues to Systemic Disease Archived 2008-05-12 at the Wayback Machine Links to pictures of Toenail Diseases ... or side effects of drugs. Onychomadesis is the separation and falling off of a nail from the nail bed. Common causes include ... systemic upsets or adverse reaction to drugs. Onychorrhexis also known as brittle nails, is brittleness with breakage of ...
Mistoprostol is a drug treatment for peptic ulcers that can also cause abortion or induce labor. The use of this drug (inserted ... Uterine hyperstimulation may result in fetal heart rate abnormalities, uterine rupture, or placental abruption. It is usually ... Briggs GG, Wan SR (June 2006). "Drug therapy during labor and delivery, part 2". Am J Health Syst Pharm. 63 (12): 1131-9. doi: ... Briggs GG, Wan SR (June 2006). "Drug therapy during labor and delivery, part 2". Am J Health Syst Pharm. 63 (12): 1131-9. doi: ...
said there was "... increasing evidence from animal studies showing that cannabinoid drugs ... induce enduring neurobehavioral ... but abnormalities in the endocannabinoid system during the phase of placental development are also linked with problems in ... Drugs in pregnancy N-acylethanolamine (NAE) Fonseca BM, Correia-da-Silva G, Almada M, Costa MA, Teixeira NA (2013). "The ... The National Institute on Drug Abuse states that further research is required to "disentangle" effects of cannabis use from a ...
658 Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. ... Chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues.: ... Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and ...
... predicting individual susceptibility to drug-induced adverse effects causing weight gain and related metabolic abnormalities. ... The non-selective melanocortin receptor agonist afamelanotide (NDP-α-MSH) has been found to induce brain-derived neurotrophic ... 190 Kb downstream of MC4R in association with severe antipsychotic-induced weight gain. This locus overlapped with the region ... and melanotan II are already used for sexual enhancement by the general population via their accessibility due to online drug ...
Coadministration of moxifloxacin with other drugs that also prolong the QT interval or induce bradycardia (e.g., beta-blockers ... including those with conduction abnormalities. The safety of moxifloxacin in human patients under age 18 has not been ... Several drugs in this class, including moxifloxacin, are not licensed by the Food and Drug Administration for use in children, ... "Center for drug evaluation and research Application number 21-598" (PDF). Food and Drug Administration (FDA). 15 April 2005. ...
Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia (inducibility of VT/VF ... The doctor will pace each chamber of the heart one by one, looking for any abnormalities. Then the electrophysiologist tries to ... A peripheral venous cannula is generally inserted to allow medication to be given such as sedatives, anesthesia, or drugs. An ... and during any abnormal heart rhythms that can be induced. EP studies are used to investigate the cause, location of origin, ...
... drug-induced neutropenia). Additionally, acute neutropenia can be commonly seen from people recovering from a viral infection ... A bone marrow biopsy can identify abnormalities in myelopoesis contributing to neutropenia such as the stage of arrest in the ... The common causes of acquired agranulocytosis including drugs (non-steroidal anti-inflammatory drugs, antiepileptics, ... Neutropenia can be the result of a variety of consequences, including from certain types of drugs, environmental toxins, ...
... regulation observed in disease states as seen in cells from patients with polycystic kidney disease or leading to drug-induced ... The Ehrlich team hypothesizes that these abnormalities in function are consequences, at least in part, of altered intracellular ...
Traish AM (2018). "The Post-finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine ... Foss GL (January 1956). "Abnormalities of form and function of the human breast". Journal of Endocrinology. 14 (1): R6-R9. ... Thompson DF, Carter JR (1993). "Drug-induced gynecomastia". Pharmacotherapy. 13 (1): 37-45. doi:10.1002/j.1875-9114.1993. ... as the drug has been associated with inducing depression, anxiety and suicidal ideation, symptoms that are particularly common ...
... particular aspirin and nonsteroidal inflammatory drug-induced asthma syndromes) and rhinitis; glaucoma; various diseases of the ... nervous system; fractures, osteoporosis, and other bone abnormalities; pulmonary fibrosis; certain forms of malignant disease ... The following drugs that act on EP2 but also other prostaglandin receptors are in clinical use: Iloprost activates EP2, EP3, ... The following drugs are in development or proposed to be candidates for development as highly selective EP2 agonists for the ...
Central nervous system tumor Central pontine myelinolysis Cerebrovascular diseases Drug induced Infectious or post infectious ... neurological abnormalities other than dystonia, abnormalities on brain imaging, particularly in the basal ganglia. To further ... These drugs have fallen out of fashion due to various serious side effects: sedation, parkinsonism, and tardive dyskinesia. ... How to induce neuroplasticity. A new approach to rehabilitate dystonias. Galene editions 2012. Adam OR, Jankovic J (2007). " ...
... all serious medical abnormalities.[citation needed] Sulfhemoglobinemia is usually drug induced, with drugs associated with it ... Gopalachar AS, Bowie VL, Bharadwaj P (June 2005). "Phenazopyridine-induced sulfhemoglobinemia". Ann Pharmacother. 39 (6): 1128- ... even though a blood count test may not show any abnormalities in the blood. This discoloration is caused by greater than 5 ... Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose (4 ed.). Saunders. p. 289. doi:10.1016/B978-0-7216- ...
... the foetus is at risk of severe abnormalities or genetic disorders.: 17 In December 2014, two drugs that induce miscarriage- ... The drugs must be prescribed by doctors at approved hospitals or clinics. Women who self-medicate to terminate pregnancies on ... there has never been any official report on the ratio of induced abortions to the number of abortions overall in Thailand," the ...
... and more rarely with anatomic pancreatic abnormalities, pseudocysts, or drug-induced pancreatitis.: 493 Factitial panniculitis ... hepatic dysfunction and coagulation abnormalities.: 494 CHP may occur either isolated or as part of cutaneous manifestations of ... is a panniculitis that may be induced by the injection of organic materials, povidone, feces, saliva, vaginal fluid, and oils ...
... drug-induced QT prolongation, Digoxin toxicity) and management of overdose (e.g., tricyclic overdose) Electrolyte abnormalities ... genetic and drug-induced Right and left atrial abnormality Electrolytes disturbances and intoxication: Digitalis intoxication ... ISBN 978-1-68185-011-5. "ECG Study Guide". Otero J, Lenihan DJ (2000). "The "normothermic" Osborn wave induced by severe ... the effects of heart drugs, and the function of implanted pacemakers. The overall goal of performing an ECG is to obtain ...
Radicals may also be involved in Parkinson's disease, senile and drug-induced deafness, schizophrenia, and Alzheimer's. The ... skin pigmentary melanin abnormalities, deafness, arthritis, and diabetes mellitus. The free-radical theory of aging proposes ... For weak bonds, homolysis can be induced thermally. Strong bonds require high energy photons or even flames to induce homolysis ... Because radicals are necessary for life, the body has a number of mechanisms to minimize radical-induced damage and to repair ...
... drug induced Dyskinesia Dysmorphism abnormal vocalization mental retardation Dysmorphism cleft palate loose skin ... retardation eye abnormality Dwarfism short limb absent fibulas very short digits Dwarfism stiff joint ocular abnormalities ... Double tachycardia induced by catecholamines Double uterus-hemivagina-renal agenesis Down syndrome Doxorubicin-induced ... Duplication of urethra Dupont-Sellier-Chochillon syndrome Dupuytren subungual exostosis Dupuytren's contracture Dust-induced ...
Acquired causes of tics include drug-induced tics, head trauma, encephalitis, stroke, and carbon monoxide poisoning. The ... Chorea (disease) Myoclonus Dystonia Torsion dystonia Idiopathic dystonia Chromosomal abnormalities Citrullinemia Down syndrome ... Cerebral palsy Creutzfeldt-Jakob disease Fetal alcohol syndrome Head trauma Hypoglycemia Intrauterine exposure to illicit drugs ...
Drug-induced Antibiotics Chemotherapeutic drugs Antiarrhythmic agents Infection Coronavirus disease 2019 Atypical pneumonia ... Virus Malignancy Lymphangitic carcinomatosis Predominately in children Diffuse developmental disorders Growth abnormalities ... the Food and Drug Administration approved a new drug for the treatment of Idiopathic Pulmonary Fibrosis (IPF). This drug, Ofev ... This drug has been shown to slow the decline of lung function although the drug has not been shown to reduce mortality or ...
... hematologic abnormalities, and systemic illness. Other synonymous names and acronyms include drug-induced hypersensitivity ... Like other SCARs-inducing drugs, DRESS syndrome-inducing drugs or their metabolites stimulate CD8+ T or CD4+ T cells to ... Bocquet H, Bagot M, Roujeau JC (December 1996). "Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with ... SCARs Adverse drug reaction Drug allergy Drug intolerance Drug tolerance List of skin conditions Eosinophilic myocarditis ...
The incidence of drug-induced parkinsonism increases with age. Drug-induced parkinsonism tends to remain at its presenting ... Chronic manganese (Mn) exposure has been shown to produce a parkinsonism-like illness characterized by movement abnormalities. ... "Information Sheet: Drug-induced Parkinsonism" (PDF). Parkinson's Disease and Society. Archived from the original (PDF) on 2013- ... Yet another drug that can induce parkinsonism is the antihistaminic medication cinnarizine, usually prescribed for motion ...
Research on the effect of the psychedelic drug psilocybin shows that the altered state of consciousness induced by this drug ... Therefore, functional abnormalities of the PCC might be an accumulation of remote and widespread damage in the brain. The PCC ... Structural and functional abnormalities in the PCC result in a range of neurological and psychiatric disorders. The PCC likely ... Abnormalities in the structure and white matter connections of the PCC have also been recorded in patients with schizophrenia. ...
Identifying whether or not abnormalities in these pathways cause myoclonus may help in efforts to develop drug treatments and ... Other receptors with links to myoclonus include those for benzodiazepines, drugs that induce sleep, and for glycine, an ... and similar drugs, and is possibly a sign of high and/or rapidly increasing serum levels of these drugs. Myoclonic jerks caused ... chemical or drug poisoning, as a side effect of certain drugs (such as tramadol, quinolones, benzodiazepine, gabapentin, ...
Drug-induced QT prolongation is often a result of treatment by antiarrhythmic drugs such as amiodarone and sotalol, antibiotics ... LQT8, also known as Timothy syndrome combines a prolonged QT interval with fused fingers or toes (syndactyly). Abnormalities of ... Arrhythmias occur more commonly in drug-induced LQTS if the medication in question has been rapidly given intravenously, or if ... Roden DM (March 2004). "Drug-induced prolongation of the QT interval". The New England Journal of Medicine. 350 (10): 1013-22. ...
... or use of enzyme inducing drugs such as phenytoin. Treatment with imidazole drugs such as etomidate, ketoconazole and ... Several blood test abnormalities can suggest corticosteroid insufficiency, such as hypoglycemia, hyponatremia, hyperkalemia, ... Furthermore, anaesthesia drugs like etomidate could interfere with the HPA axis. The secretion also loses its normal diurnal ... Both a metyrapone-induced decrease in cortisol and hypoglycemia are potentially harmful to intensive care patients. The exact ...
Like other SCARs-inducing drugs, SJS-inducing drugs or their metabolites stimulate CD8+ T cells or CD4+ T cells to initiate ... when taking the drug. In addition to abnormalities in drug-metabolizing enzymes, dysfunctions of the kidney, liver, or GI tract ... a drug's ability to induce SCARs is limited to those individuals who express HLA serotypes targeted by the drug or its ... Fan WL, Shiao MS, Hui RC, Su SC, Wang CW, Chang YC, Chung WH (2017). "HLA Association with Drug-Induced Adverse Reactions". ...
... exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and ... and cellular adaptations that occur in specific brain regions to mediate addiction-associated behavioral abnormalities. These ... Genetic factors and mental disorders can contribute to the severity of drug addiction. Approximately fifty percent of the ... Despite the importance of numerous psychosocial factors, at its core, drug addiction involves a biological process: the ability ...
Pregnancy-induced hypertension and pre-eclampsia[edit]. Pregnancy-induced hypertension is diagnosed when maternal systolic ... "Drug and Chemical Toxicology. 23 (4): 603-20. doi:10.1081/DCT-100101973. PMID 11071397. S2CID 30289350. Archived from the ... Hypothyroidism is the most common thyroid abnormality associated with[vague] PFAS exposure.[39] PFASs have been shown to ... Li K, Gao P, Xiang P, Zhang X, Cui X, Ma LQ (February 2017). "Molecular mechanisms of PFOA-induced toxicity in animals and ...
Fitzpatrick, MO; Maxwell, WL; Graham, DI «The role of the axolemma in the initiation of traumatically induced axonal injury» ( ... Clin Drug Investig, 2013 Jul; 33 (7), pp: 497-503. DOI: 10.1007/s40261-013-0090-0. PMC: 3691490. PMID: 23740337 [Consulta: 27 ... Intraosseous intraneural perineurioma derived from the inferior alveolar nerve with an abnormality of chromosome 22 and ... Schloss JM, Colosimo M, Airey C, Vitetta L «Chemotherapy-induced peripheral neuropathy (CIPN) and vitamin B12 deficiency» (en ...
The abnormality lies in this excessive vagal response causing loss of blood flow to the brain.[9] The tilt-table test typically ... He was diagnosed with exercise-induced ventricular tachycardia at the time. There was speculation that he had since stopped ... drug intoxication and some psychiatric disorders among others.[1] Treatment depends on the underlying cause.[1][3] Those who ... High risk is anyone who has: congestive heart failure, hematocrit ,30%, electrocardiograph abnormality, shortness of breath, or ...
... drug-induced neutropenia). Additionally, acute neutropenia can be commonly seen from people recovering from a viral infection ... A bone marrow biopsy can identify abnormalities in myelopoesis contributing to neutropenia such as the stage of arrest in the ... The common causes of acquired agranulocytosis including drugs (non-steroidal anti-inflammatory drugs, antiepileptics, ... Patients with neutropenia caused by cancer treatment can be given antifungal drugs. A Cochrane review [44] found that lipid ...
... amyloid-related imaging abnormalities)[269]。其他研究中的方法還有神經保護物質和降低金屬蛋白交互作用的物質(如PBT2(英语:PBT2))[270]。恩博是一種能阻斷TNFα受體的融合蛋白,近年已有部分令人振奮的 ... Drugs. 2010, 70 (5): 513-28 [2019-01-10]. PMID 20329802. doi:10.2165/11533070-000000000-00000. (原始内容存档于2011-09-17) (英语).. ... Aß Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide
"Drug Information Portal. U.S. National Library of Medicine.. *. "alpha-tocopherol". Drug Information Portal. U.S. National ... Vitamin E deficiency is rare in humans, occurring as a consequence of abnormalities in dietary fat absorption or metabolism ... However, under stressed growing conditions such as drought, elevated temperature or salt-induced oxidative stress, the plants' ... "Overview from the US Food & Drug Administration. Retrieved 24 August 2018.. *^ "Alliance for Natural Health v. Sebelius, Case ...
... indicating that the pain of lameness is relieved by the drug.[26] In self-selection experiments, lame birds select more drugged ... Lauber, J.K. & Kinnear, A. (1979). "Eye enlargement in birds induced by dim light". Canadian Journal of Ophthalmology. 14 (4): ... In one example of these scales, GS=0 indicates normal walking ability, GS=3 indicates an obvious gait abnormality which affects ... Selection and husbandry for very fast growth means there is a genetically induced mismatch between the energy-supplying organs ...
Salgia, R (March 1998). "Molecular abnormalities in lung cancer". Journal of Clinical Oncology. 16 (3): 1207-1217. PMID 9508209 ... Azim, HA (March 2007). "Treatment options for relapsed small-cell lung cancer". Anticancer drugs. 18 (3): 255-261. doi:10.1097/ ... "Tobacco carcinogens, their biomarkers and tobacco-induced cancer". Nature Reviews Cancer. Nature Publishing Group. 3 (10): 733 ...
Some diseases are inherent abnormalities of skin structure or function. These include seborrheic dermatitis, ichthyosis, skin ... Treatment of autoimmune skin requires methods to reduce the abnormal immune response; steroids, azathioprine and other drugs ... a process in which allergens are injected to try to induce tolerance).[7] In many cases, shampoos, medicated wipes and ear ... These include many endocrine (hormonal) abnormalities, such as hypothyroidism, Cushing's syndrome (hyperadrenocorticism), and ...
Stress, either severe, acute stress or chronic low-grade stress may induce abnormalities in three principal regulatory systems ... Stress may precipitate abuse of drugs and/or alcohol.[6] Stress may also contribute to aging and chronic diseases in aging, ... Aggressive behavior has also been associated with abnormalities in these systems.[36] ... "Effects of the Transcendental Meditation program on neuroendocrine abnormalities associated with aggression and crime". Journal ...
An important downstream target of ATM and ATR is p53, as it is required for inducing apoptosis following DNA damage.[56] The ... Many other drugs for use against other residual DNA repair mechanisms commonly found in cancer are currently under ... Classically, cancer has been viewed as a set of diseases that are driven by progressive genetic abnormalities that include ... Ionizing irradiation can induces a highly complex form of DNA damage as clustered damage. It consists of different types of DNA ...
"Drug-induced arrhythmia". Circulation. 122 (14): 1426-1435. doi:10.1161/circulationaha.109.894725. PMID 20921449.. ... Medical assessment of the abnormality using an electrocardiogram is one way to diagnose and assess the risk of any given ... Other drugs[edit]. Several groups of drugs slow conduction through the heart, without actually preventing an arrhythmia. These ... Although the goal of drug therapy is to prevent arrhythmia, nearly every antiarrhythmic drug has the potential to act as a pro- ...
Induced mutation[edit]. Induced mutations are alterations in the gene after it has come in contact with mutagens and ... "Yeasts acquire resistance secondary to antifungal drug treatment by adaptive mutagenesis". PLOS ONE. 7 (7): e42279. Bibcode ... See also: Chromosome abnormality. Large-scale mutations in chromosomal structure include: *Amplifications (or gene duplications ... UV light can induce adjacent pyrimidine bases in a DNA strand to become covalently joined as a pyrimidine dimer. UV radiation, ...
... although these drugs carry a risk of drug dependence and other side effects.[73] Examples include morphine, fentanyl, oxycodone ... Occlusal abnormalities are incredibly common, and most people with occlusal abnormalities do not have TMD.[35] Although ... It has been postulated that such events induce anxiety and cause increased jaw muscle activity. Muscular hyperactivity has also ... Many drugs have been used to treat TMD pain, such as analgesics (pain killers), benzodiazepines (e.g. clonazepam, prazepam, ...
... or of a genetic or chromosomal abnormality.[citation needed] ... do not feel forced to turn to DIY remedies such as buying drugs ... Feminizing hormone therapy usually includes medication to suppress testosterone production and induce feminization. Types of ...
"Drugs@FDA: FDA-Approved Drugs". Retrieved 26 February 2022.. *^ a b c d e f g h Dolder PC, Strajhar P, Vizeli P, Hammann F, ... and PKCβ knock-out mice display decreased AMPH-induced efflux that correlates with reduced AMPH-induced locomotion [72].. ... studies suggest that long-term treatment with amphetamine decreases abnormalities in brain structure and function found in ... "Lisdexamfetamine - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.. *^ Drugs of Abuse (PDF). Drug Enforcement ...
"FDA Approves First Drug Treatment for Late-Stage Cervical Cancer". U.S. Food and Drug Administration. 15 June 2006. Archived ... Smoking can increase the risk in women a few different ways, which can be by direct and indirect methods of inducing cervical ... was developed to place emphasis on the spectrum of abnormality in these lesions, and to help standardize treatment. It ... On 15 June 2006, the US Food and Drug Administration approved the use of a combination of two chemotherapy drugs, hycamtin and ...
Extremely low blood pressure can also result from drug overdose and reactions to drugs. Therefore, brain ischemia can result ... Seizures can induce more damage; accordingly, anticonvulsants should be prescribed and should a seizure occur, aggressive ... Brain ischemia has been linked to a variety of diseases or abnormalities. Individuals with sickle cell anemia, compressed blood ... In 1974, Hossmann and Zimmermann demonstrated that ischemia induced in mammalian brains for up to an hour can be at least ...
Center for Drug Evaluation and (2022-10-31). "Public Notification: Artri King contains hidden drug ingredients". FDA. Patel, ... Weber S, Habel U, Amunts K, Schneider F (2008). "Structural brain abnormalities in psychopaths-a review". Behavioral Sciences ... Siminoski K, Goss P, Drucker DJ (November 1989). "The Cushing syndrome induced by medroxyprogesterone acetate". Annals of ... Some sources however do not consider the glucocorticoid medication-induced condition as "Cushing's syndrome" proper, instead ...
In 1978 the Food and Drug Administration required zinc to be in total parenteral nutrition fluids. In the 1990s there was ... Funk AE, Day FA, Brady FO (1987). "Displacement of zinc and copper from copper-induced metallothionein by cadmium and by ... Moderate and more severe zinc deficiencies are associated with behavioral abnormalities, such as irritability, lethargy, and ...
"The Top 200 Drugs of 2019". ClinCalc.com. 10 October 2012. Retrieved 27 February 2020. "Levothyroxine - Drug Usage Statistics, ... 8133-4. ISBN 978-3-85200-181-4. Bocchetta A, Loviselli A (September 2006). "Lithium treatment and thyroid abnormalities". ... which is considered goiter-inducing. Levothyroxine is also used as interventional therapy in people with nodular thyroid ... "Levothyroxine". Drug Information Portal. U.S. National Library of Medicine. "Levothyroxine sodium". Drug Information Portal. U. ...
Kashin-Beck is a result of combinatorial environmentally induced by factors such as: toxic mould, contaminated grains by ... "Inactivation of Pten in Osteo-Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth". ... fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on ...
Foremost among these abnormalities is the fact that the neurons are usually harvested as neural stem cells from a fetus and are ... It has been used not only in the study of neuronal plasticity and information processing but also in drug and toxin effects on ... This can be done by inducing network bursts or by inputting specific patterns to the neurons, from which the network is ... However, confounding this experimental technique is the fact that normal neuronal development induces change in array-wide ...
The abnormalities seen in the SPECT images are very similar to those seen in people with cerebral vacuities and Creutzfeldt- ... It was granted fast track designation by the U.S. Food and Drug Administration in July 2017. In April 2020 Pfizer paid $130 ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... On 21 December 1998, the Food and Drug Administration (FDA) approved LYMErix on the basis of these trials for persons of ages ...
The drug LY354740 (also known as Eglumegad, an mGlu2/3 agonist) was shown to attenuate physiologic and cognitive abnormalities ... Due to its hydrophilic character, IP3 can travel to the endoplasmic reticulum, where it induces, via fixation on its receptor, ... The same drug has been shown to interfere in the hypothalamic-pituitary-adrenal axis, with chronic oral administration of this ... Drug Discovery. 4 (2): 131-44. doi:10.1038/nrd1630. PMID 15665858. S2CID 15037387. Skeberdis VA, Lan J, Opitz T, Zheng X, ...
Hyponatraemia (which leads to delirium) can complicate oxytocin treatment, usually when given to induce an abortion. By 1975, ... Inhibition of steroid sulphatase caused behavioural abnormalities in mice. A recent hypothesis, supported by collateral studies ... Atypical antipsychotic drugs and pregnancy outcome: a prospective, cohort study. Journal of Clinical Psychopharmacology 33: 453 ... such as lithium and anti-convulsant drugs, has been employed with success. Electroconvulsive therapy has the reputation of ...
In a cohort study of previously treated patients, ibrutinib induced responses in 91% of patients, and at 2 years 69% of ... Coagulation abnormalities may be present. Prothrombin time, activated partial thromboplastin time, thrombin time, and ... Based on this study, the Food and Drug Administration approved ibrutinib for use in Waldenström macroglobulinemia in 2015. ... Mensah-Osman, E.; Al-Katib, A.; Dandashi, M.; Mohammad, R. (2003). "XK469, a topo IIbeta inhibitor, induces apoptosis in ...
... congenital abnormalities, and the use of cancer drugs. Her innovation in manipulation of the mouse genome led to the mouse ... They then use this information to research how to change human iPS cells (induced pluripotent stem cells) into cell types that ...
"FDA approves new drug for advanced prostate cancer" (Press release). Food and Drug Administration. 15 May 2013. Archived from ... 5-LOX can be induced by proinflammatory stimuli and is expressed in epithelial cancers including lung, prostate, breast, and ... Digital rectal examination may allow a doctor to detect prostate abnormalities. Cystoscopy shows the urinary tract from inside ... based National Prostate Cancer Coalition stated that prostate cancer drugs were outnumbered seven to one by breast cancer drugs ...
Principles for the testing of drugs for teratogenicity : report of a WHO scientific group [‎meeting held in Geneva from 14 to ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎World Health ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Organización ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Organisation ...
Principles for the testing of drugs for teratogenicity : report of a WHO scientific group [‎meeting held in Geneva from 14 to ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎World Health ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Organización ... WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity; World Health Organization (‎Organisation ...
Results of search for su:{Abnormalities, Drug-induced} Refine your search. *. Availability. * Limit to currently available ... Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins. by Hawkins, Denis Frank. ... Principles for the testing of drugs for teratogenicity : report of a WHO scientific group [meeting held in Geneva from 14 to 19 ... by WHO Scientific Group on Principles for the Testing of Drugs for Teratogenicity , World Health Organization. ...
Some medicines can harm your baby, including over-the-counter drugs, herbs and supplements. ... ClinicalTrials.gov: Abnormalities, Drug-Induced (National Institutes of Health) Journal Articles References and abstracts from ... Index to Drug-Specific Information (Food and Drug Administration) * Prescription Opioids during Pregnancy (March of Dimes Birth ... Food and Drug Administration) Also in Spanish * Pregnancy and Medicines (Department of Health and Human Services, Office on ...
"drug-related side effects and adverse reactions"[MESH]. OR "abnormalities, drug-induced"[MESH] ... Drug class. Drug name. Maternal or fetal/child. Timing. Adverse effect. N studies. Effect size (95% CI). ... OR congenital abnormality. OR ((adverse or undesirable or harm or harms or harmful or toxic or injurious or serious or fatal) ... OR congenital abnormality. OR ((adverse or undesirable or harm or harms or harmful or toxic or injurious or serious or fatal) ...
Its principal abnormality is diastolic dysfunction-specifically, restricted ventricular filling. ... Drug-induced RCM is a rare disorder that has been described with long-term use of the antimalarial medications chloroquine and ... These changes lead to abnormalities of contractility, conduction, and coronary blood flow. Interestingly, amyloid deposition in ... Hanna M. Novel drugs targeting transthyretin amyloidosis. Curr Heart Fail Rep. 2014 Mar. 11 (1):50-7. [QxMD MEDLINE Link]. ...
Abnormalities in polymorphonuclear leukocytes. *. Decreased levels associated with cyclic neutropenia, drug-induced neutropenia ... Drugs & Diseases , Infectious Diseases Pneumococcal Infections (Streptococcus pneumoniae) Clinical Presentation. Updated: Jun ... Immunosuppressive drugs or radiation therapy, malignant neoplasms, leukemias, lymphomas, Hodgkin disease, solid organ ... Antimicrobial activity of ceftaroline tested against drug-resistant subsets of Streptococcus pneumoniae from U.S. medical ...
Abnormalities, Drug-Induced / etiology* * Adolescent * Adult * Antipsychotic Agents / toxicity* * Case-Control Studies ...
Abnormalities, Drug-Induced. Subject:. Health risk assessment. Subject:. Developmental toxicology. Other copies:. Look for ...
Over the past 8 years, sporadic outbreaks of MPTP-induced parkinsonism have occurred among drug abusers in California, Maryland ... In addition, neurochemical abnormalities resembling those seen in patients with Parkinsons disease have been noted. These ... Street-Drug Contaminant causing Parkinsonism The following information was submitted by the National Institute on Drug Abuse ... Recently, a street-drug contaminant has appeared that can cause parkinsonism in drug abusers. The compound N-methyl-4-phenyl-1 ...
"Severe and unrecognized dental abnormalities after drug-induced epidermal necrolysis". Archives of Dermatology. 145 (11): 1332- ... Thalidomide (N-phthaloylglutamine) was also discovered to have a causative effect on mothers who took the drug during pregnancy ... Exposure to PCBs (such as dioxin), allergies, and toxic epidermal necrolysis folloeing a drug reaction may also be contributing ... It usually occurs as part of a syndrome that involves other abnormalities and requires multidisciplinary treatment. The ...
Abnormalities, Drug-Induced * Breast Feeding * Female * Fertility * Fetus / drug effects * Graft Rejection ...
Genetic factors may increase the risk of drug induced methemoglobinemia and hemolytic anemia [McDonagh et al. 2013]. ... Presence of other abnormal hemoglobin species (structural abnormalities of the hemoglobin molecule itself) including ... Recreational drug users are at increased exposure risk, especially users of volatile nitrite inhalers and drugs like cocaine. ... the major enzyme responsible for reduction of induced methemoglobin back to normal hemoglobin, has only about half the activity ...
... and the most recognized is drug-induced gingival enlargement. Furthermore, causes of congenital gingival enlargement include ... to help identify the causes of abnormalities of the oral cavity. ... Drug-Induced Gingival Hyperplasia) and Drug-Induced Gingival ... Drug-induced gingival overgrowth, also known as gingival hyperplasia secondary to drugs, was first reported in the dental ... No age predilection exists for the onset of drug-induced gingival overgrowth; however, phenytoin-induced gingival overgrowth ...
Drug-induced PRCA is a rare blood disorder in adults and has already been reported in isoniazid-treated patients (3-5). For ... Upper and lower digestive tract endoscopic examination and carcinoembryonic antigen showed no abnormalities, which lessened the ... In view of previous reports of isoniazid-induced PRCA (3-5), we suspected this drug to be responsible in this case. Isoniazid ... PRCA occurs secondary to drug exposure in 5% of patients; ≈30 drugs have been implicated (2), and few reports involving ...
Abnormalities, Drug-induced. *Peptic Ulcer. *Respiratory Tract Diseases. How long have you been taking it?. Choose one ...
Abnormalities, Drug-induced. *Bradycardia. *Colic. *Colonic Diseases. *Common Cold. *Diverticulitis. *Drug Toxicity ...
Abnormalities, Drug-induced. *Bacteriuria. *Colic. *Cyanosis. *Cystitis. *Herpes Simplex. *Hyperhidrosis. *Intraoperative ...
Drug-Induced Disorders of the Nervous System; 33. Alcohol and the Nervous System; 34. Neurologic Complications of Recreational ... Abnormalities of Thermal Regulation and the Nervous System; 38. Postconcussion Syndrome. Section XI: Infectious, Inflammatory, ...
Some evidence suggests that anti-epileptic drugs may induce psychotic symptoms in patients with interictal psychosis. ... The occurrence of interictal psychosis may indicate widespread abnormalities in the brain, or a brain tumor. Typically, ... This diagnosis is not given when symptoms are a result of drug use or drug withdrawal; the DSM-5 classifies this as substance- ... Postictal psychosis is most commonly seen in people with a long history of drug-resistant seizures. According to research, ...
Full featured search for drugs, conditions, diseases, and drug policies on WorstPills ... Drug Induced Psychiatric Symptoms October 2002 This is the first of a two part series on drug induced psychiatric symptoms that ... Some of these interactions can lead to an increased risk of fatal heart rhythm abnormalities. ... An Update on Drug-Induced Parkinsonism October 2019 Next to Parkinsons disease, drug-induced parkinsonism is the second most ...
... discontinuation of mesalazine has been reported. ... Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Respiratory Diseases : CK(652) : AC(103), Ulcerative Colitis : CK(666) : ... Improvement in clinical symptoms and radiological abnormalities occurred spontaneously after discontinuation of mesalazine. ... We reported a case of drug-induced lung injury associated with mesalazine. A 50-year-old woman was diagnosed as having ...
Women are also more likely to experience drug-induced heart-rhythm abnormalities, and the risk is highest during the first half ... The problem, to state the obvious, is that those complicated bodies are going to be taking the drugs anyway, so it would be ...
Drug Induced Liver Injury (DILI)- An important cause of Liver Abnormality in India ... Drug induced liver injury or DILI, as the name suggests, is an adverse reaction of any medication or substance which causes ... This contrasts with traditional non-biologic pharmaceutical drugs, developed in a laboratory via chemical processes without ...
PW1: Cholesterol Abnormalities & Drug-Induced Nutrients Depletions Price: $95.00 Continuing Education Credits. 2.5 hours of ... Alan Gaby, MD: Various Approaches for the Treatment of Cholesterol Abnormalities. Alan C. Simon, R.Ph: Drug-Induced Nutrients ...
In summary, the mechanism by which Stattic induces apoptosis in MV4-11cells may involve blocking DNA damage repair machineries. ... In summary, the mechanism by which Stattic induces apoptosis in MV4-11cells may involve blocking DNA damage repair machineries ... Most traditional chemotherapeutic drugs kill leukemia cells by inducing DSBs, the accumulation of which leads to apoptosis ( ... patients with FLT3-ITD mutation recurrence often have new cytogenetic and molecular abnormalities and a higher FLT3-ITD/FLT3- ...
2. Wolkowicz J, Sturgeon J, Rawji M, Chan CK "Bleomycin-induced pulmonary function abnormalities." Chest 101 (1992): 97-101 ... Subscribe to Drugs.com newsletters Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, ... Drugs.com Mobile Apps The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ...
... and history of drug induced leukopenia/neutropenia. In patients with a pre-existing low WBC or ANC or a history of drug-induced ... Laboratory Test Abnormalities: Transaminases: Transient elevations in serum transaminases (primarily ALT) in the short-term ... 7 DRUG INTERACTIONS 7.1 Drugs Having Clinically Important Drug Interactions with Asenapine 7.2 Drugs Having No Clinically ... Concomitant Drug Name or Drug Class Clinical Rationale. Clinical Recommendation. Antihypertensive Drugs Because of its α1- ...
  • Avoid ANZEMET in patients with congenital long QT syndrome, hypomagnesemia, hypokalemia, patients taking diuretics with potential for inducing electrolyte abnormalities or anti-arrhythmic drugs or drugs that lead to QT prolongation or cumulative high dose anthracycline therapy. (anzemet.com)
  • Monitor for electrolyte abnormalities, hematologic toxicity. (clinicaladvisor.com)
  • Skip the drug suspected and electrolyte abnormalities, however, and sometimes drug withdrawal and self-limiting. (lapelpinzone.com)
  • Improvement in clinical symptoms and radiological abnormalities occurred spontaneously after discontinuation of mesalazine. (greenmedinfo.com)
  • Even though the signs and symptoms of mesalazine-induced lung injury are similar to those of the pulmonary involvement of inflammatory bowel disease, it is important to distinguish them differences. (greenmedinfo.com)
  • Doctors use the term drug-induced liver injury (DILI) to refer to any liver damage caused by medications, whether it results in symptoms or not. (msdmanuals.com)
  • Other potential or concomitant alimentary factors that are able to induce symptoms include carbohydrates (fermentable oligo-, di-, monosaccharides and polyols, FODMAPs) and wheat proteins such as amylase/trypsin inhibitors (ATIs). (worldgastroenterology.org)
  • I was somewhat confused in doing the analysis, as patient had mixed symptoms, drug induced symptoms plus her own symptoms. (hpathy.com)
  • More substances have been found to be capable of inducing, in normal subjects, psychopathological symptoms~ usually of the dissociative type, bearing a resemblance to those observed in mental patients. (erowid.org)
  • These pictures provide a concrete, visible material, which is perhaps more effective than written records, which, as they are largely based on introspection by the subject studied, are often subject to alterations induced by the mnemic recall of the symptoms. (erowid.org)
  • We routinely post information that may reflect drug hypersensitivity have been rare prandin insulin reports of obstructive symptoms in patients at risk. (squabash.com)
  • Reports documenting signs, symptoms, and abnormalities suffered while exercising are expected. (keefelaw.com)
  • Ibrutinib is a well-tolerated, oral drug that improves symptoms and survival in high-risk CLL patients, but is not curative and requires continuous treatment for life. (newswise.com)
  • If you suspect your child has suffered a birth injury, either from the decision to induce labor or the decision not to, there are certain signs and symptoms you should look for and then discuss with your pediatrician. (sokolovelaw.com)
  • Of note, 15 of the 17 patients with genetic myopathies had elevated CK levels, ranging from 4 to 10 times the upper limit of normal, so an elevated serum CK should be found in most, but not all, patients with drug-induced symptoms associated with genetic myopathies. (reliasmedia.com)
  • Regarding the reduced levels of coenzyme Q10 in the muscle biopsies, similar findings have been reported in some prior studies of patients with statin-induced muscle symptoms. (reliasmedia.com)
  • Amoxicillin-Induced exanthema in association with your symptoms can return. (lapelpinzone.com)
  • Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, pares-thesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. (elsevier.com)
  • COVID-19 Affects Brain 6 Months After Symptoms, Research Finds Scientists have found that COVID-19 causes brain 'abnormalities' even 6 months after symptoms are gone. (medscape.com)
  • Dogs with other cardiac abnormalities or arrhythmias may also be identified. (gopetsamerica.com)
  • Administering calcium gluconate intravenously can reverse electrocardiographic changes and arrhythmias induced by hyperkalemia ( 12946 ). (therapeuticresearch.com)
  • The use of CNS stimulants is contraindicated in patients with significant cardiovascular impairment such as uncompensated heart failure, severe coronary disease, severe hypertension (including that associated with hyperthyroidism or pheochromocytoma), cardiac structural abnormalities, serious arrhythmias, etc. (drugs.com)
  • I further investigated electromechanical trigger-substrate interactions prior to sympathetically-induced arrhythmias in a canine drug-induced long-QT syndrome model (and was awarded the EWGCCE Travel Award). (carimmaastricht.nl)
  • Heart medicines - Certain heart medications can induce arrhythmias that lead to sudden cardiac death under certain circumstances. (aedusa.com)
  • IMSEAR at SEARO: Losartan induced fetal toxicity. (who.int)
  • Although the teratogenic effects of angiotensin converting enzyme (ACE) inhibitors are well documented there are limited reports of losartan induced fetal toxicity. (who.int)
  • Losartan induced fetal toxicity. (who.int)
  • INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. (nih.gov)
  • Despite widespread drug exposure, for example during gestation or in prematurely born children, organ-specific developmental toxicity of most drugs is poorly understood. (biorxiv.org)
  • In conclusion, the presented study demonstrates the large-scale screening of kidney-specific toxicity of approved drugs in a live vertebrate embryo. (biorxiv.org)
  • The methanolic extract of Buchholzia coriacea seeds (MEBC) has been reported to induce male reproductive toxicity by decreasing sperm parameters and fertility index. (scielo.br)
  • The result suggests that Buchholzia coriacea seeds induce male reproductive toxicity by suppressing the pituitary-gonadal axis. (scielo.br)
  • Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. (abnova.com)
  • Herbal medicines and their constituents can alter the activity or expression of drug-metabolizing enzymes, which can lead to changes in the efficacy and toxicity of conventional drugs. (jkom.org)
  • In general, studies on the safety of herbal medicines, including herbal formulas, should include at least in vitro and in vivo genotoxicity assays, long-term rodent carcinogenicity tests, reproductive and developmental toxicity studies, and investigation of their effects on drug-metabolizing enzymes 2) . (jkom.org)
  • Acute hepatitis A or B can be confirmed serologically, as can hepatitis C. Negative serological findings in the presence of hepatitis-like chemistry abnormalities may also suggest acute drug-induced hepatitis, an impression supported by resolution after removal of the offending agent. (labcorp.com)
  • Women of every social class are in need of abortions around the world for various reasons such as financial instability, pregnancy as a result of rape or incest, when fetus have congenital abnormality such as congenital heart defects, orofacial clefts, down syndrome, neural tube defects, when the continuation of pregnancy have harmful effects on mother or when mother is suffering from diseases such as hepatitis (Lowen, Lowen, & NPR). (coursehero.com)
  • Nevertheless, acute hepatitis can result from a wide variety of noninfectious causes that include but not limited to are drugs (drug-induced hepatitis), alcohol (alcoholic hepatitis), immunologic (autoimmune hepatitis, primary biliary cholangitis) or as a result of indirect insult secondary to biliary tract dysfunction (cholestatic hepatitis), pregnancy-related liver dysfunction, shock or metastatic disease. (statpearls.com)
  • Just after two days of addition of pimozide to the ongoing therapy, jaundice and elevated liver enzymes were detected which may indicate a drug induced hepatitis. (ppri.pk)
  • Patient was diagnosed with drug induced cholestatic hepatitis by gastroenterology department. (ppri.pk)
  • Etiologic diagnosis of hepatitis is even more problematic in organ transplant recipients because a wide range of possible drug toxicities induced by immunosuppressive therapies must be considered ( 4 ). (cdc.gov)
  • High cholesterol levels and other metabolic abnormalities can lead to fatty hepatitis. (terpsichoresand.org)
  • Adisa RA, Choudharyb MI, Olorunsogo OO.Hypoglycemic activity of Buchholzia coriacea (Capparaceae) seeds in streptozotocin-induced diabetic rats and mice.Elsevier Gmbh, Exp Toxicol Pathol. (scielo.br)
  • A research team, led by ophthalmologist Mara Lorenzi of the Schepens Eye Research Institute at Harvard Medical School, compared the impact of clopidogrel, a selective anti-platelet drug, with the effect of aspirin in rats with streptozotocin-induced diabetes. (reviewofoptometry.com)
  • LD (LDH) abnormality with elevation of hepatic fractions was also reported. (labcorp.com)
  • Acute hepatic inflammation can be caused by many infectious and noninfectious causes, of which the most common causes are secondary to a viral infection or drug-induced liver injury. (statpearls.com)
  • Approximately 73% of all known drugs are metabolized by hepatic CYP450 4) . (jkom.org)
  • A fatty liver is a disease of the liver that is caused by an abnormality in the hepatic cells. (terpsichoresand.org)
  • Our results are saying that if cells in these experiments are senescing and undergoing apoptosis, any conclusions we draw from that might not apply to what drugs are being tested on them, but from how the cells were derived,' Lanza says. (scientificamerican.com)
  • This may be related to mitochondrial proteins that regulate apoptosis and necrosis and that are shown to be induced in mouse fatty liver models. (medscape.com)
  • However, aspirin at doses far below the anti-inflammatory range for humans did prevent apoptosis of capillary cells and the development of acellular capillaries, but did not prevent neuroglial abnormalities. (reviewofoptometry.com)
  • Blocking autophagy has potential in the treatment of colon cancer by inducing apoptosis via p53 and ER stress, and suppressing the UPR pathway is a valid strategy to overcome resistance to autophagic inhibition. (biomedcentral.com)
  • Conclusions The outcomes suggested that apigenin inhibits T-24 cells proliferation via blocking cell routine inducing and development apoptosis. (gbic2012.org)
  • Furthermore, intracellular reduced glutathione (GSH) content material has a decisive effect on anticancer drug-induced apoptosis, indicating that apoptotic effects are inversely proportional to GSH content material [15,16]. (gbic2012.org)
  • Taking place apigenin is available mainly in hydroxylated type Normally, and it has been proven to inhibit tumour cell proliferation, motility, angiogenesis, and induce apoptosis [22-25]. (gbic2012.org)
  • We demonstrated that apigenin inhibited T-24 cells proliferation via blocking cell routine inducing and development apoptosis. (gbic2012.org)
  • Dr Huang studied colorectal cancer stem cells, and found curcumin couples with the CD44 cancer stem cell membrane marker, and "might have some blocking effect on the transport of glutamine into the cells , thus decreasing the glutamine content in the CD44+ cells and inducing apoptosis. (greenmedinfo.com)
  • [ 4 ] Similarly, nonsteroidal anti-inflammatory drugs (NSAIDs), commonly prescribed for treating migraine outside pregnancy, can potentially lead to spontaneous abortion (early in pregnancy) and fetal developmental malformations, such as premature closure of the ductus arteriosus and oligohydramnios (in the third trimester). (medscape.com)
  • Ledoxina can cause fetal harm when administered to a pregnant woman and such abnormalities have been reported following Ledoxina therapy in pregnant women. (sdrugs.com)
  • 6) "Fatal fetal abnormality" means a terminal condition that, in reasonable medical judgment, regardless of the provision of life-saving medical treatment, is incompatible with life outside the womb and will result in death upon birth or imminently thereafter. (fl.us)
  • It also aims to determine the risk for coagulation during pregnancy, incidence of hereditary or acquired coagulation disorders in pregnant women, risk for regional anesthesia administration in pregnant women with coagulation abnormalities, rate of transfusion in women with PPH, and pharmacological treatment for pregnant women with coagulation disorders under special circumstances such as intrauterine fetal death. (anesth-pain-med.org)
  • A recent clinical trial indicates that many persons with obsessive-compulsive disorder who respond favorably to joint behavioral and drug treatment may then safely taper their medication use very slowly to elimination, though careful follow-up clinical monitoring is still essential. (worstpills.org)
  • A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE , caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. (nih.gov)
  • He notes his company had planned this year to apply to the U.S. Food and Drug Administration to use red blood cells and platelets derived from iPS cells in clinical trials, but 'at this point, therapies with these cells are years off. (scientificamerican.com)
  • Although no clinical trials involving therapies derived from iPS cells are on the books, researchers are currently testing drugs on them. (scientificamerican.com)
  • At the same time, the results provide further clinical evidence of ABC-DLBCL drug-resistant molecules and provide a theoretical basis for rational second-line treatment after drug resistance. (hindawi.com)
  • Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need for the antiepileptic drug. (medicinenet.com)
  • The widespread use of statins has resulted in these drugs becoming the commonest defined cause of myalgia and hyperCKaemia in clinical practice. (musculoskeletalkey.com)
  • As with muscle diseases, in general, it is possible to classify drug and toxic effects on skeletal muscle in a number of ways, including clinical syndromes that arise, the pathogenic actions of the drugs or toxins and by pathological features. (musculoskeletalkey.com)
  • Some drugs and toxins produce a specific pathology, but others can cause a variety of pathological changes and clinical presentations. (musculoskeletalkey.com)
  • These trends put patients at increased risk of drug-drug interactions with uncertain gains for quality of care and clinical outcomes," the researchers stated. (cchrint.org)
  • One point concerns the relationship between the manifestations induced by these drugs and those observed in psychoses, especially schizophrenia: is there a true analogy between the clinical condition and that produced experimentally? (erowid.org)
  • Clinical studies, epidemiological studies and post-market pharmacovigilence are of utmost importance in recognizing signals and drug-induced side effects. (restorativemedicine.org)
  • For practical purposes, this diagnosis signifies the development of a lupus-like illness with characteristic clinical and serological abnormalities after exposure to an offending agent. (dermatologyadvisor.com)
  • The Company exploits a wide array of computational discovery and can i buy robaxin online therapeutic drug platforms for the treatment of active polyarticular course juvenile idiopathic arthritis (pcJIA) in patients with hyperlipidemia according to clinical guidelines. (vfecto.com)
  • The difference between the response of the drugs and the response of the placebo was less than two points on average on a clinical scale that goes from fifty to sixty points. (newagora.ca)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
  • AI 'Simulants' Could Save Time and Money on New Medications Artificial intelligence is poised to make clinical trials and drug development faster, cheaper, and more efficient. (medscape.com)
  • Pavithra S, Kavitha S, Odayappan A. Steroid Induced Glaucoma in a Child with Acute Lymphoblastic Leukemia - An Overlooked Complication. (pediatriconcall.com)
  • Wilson & McQueen, PLLC is reviewing potential claims of those who suffered acute kidney failure or diabetic ketoacidosis (DKA) after ingesting either drug or any of these other SGLT2 inhibitors: Farxiga, Xigduo XR, Jardiance and Glyxambi. (wmkylaw.com)
  • however, the potential causal relationship to exposure with nephrotoxic drugs during nephrogenesis is widely unknown. (biorxiv.org)
  • As such, the results from first-admission studies - as a group - are confounded by drug exposure. (mindfreedom.org)
  • To counter this problem, Moncrieff and Leo analyzed the results from studies of schizophrenia patients who were either drug naïve or had limited exposure to antipsychotics (on average less than four weeks. (mindfreedom.org)
  • When fibrosis is linked to exposure to a drug or to "allergenic" molecules, the evolution generally stops when the exposure stops. (cleverlysmart.com)
  • These behavioral abnormalities develop gradually during repeated exposure to a drug of abuse, and can persist for months or years after discontinuation of use, suggesting that this addiction can be considered a form of drug-induced neural plasticity. (uninsubria.it)
  • The child cannot have a chromosomal abnormality or genetic syndrome. (wmkylaw.com)
  • Furthermore, cell lines derived from human leukaemic cells with the same chromosomal abnormality were available. (nature.com)
  • It prohibits mail delivery of abortion-inducing drugs. (hrwf.eu)
  • 9) "Medical abortion" means the administration or use of an abortion-inducing drug to induce an abortion. (fl.us)
  • Ghanaian women requiring abortion care resort to seeing quack doctors, attempt to induce abortions themselves, or take any number of herbal and medicinal concoctions to induce a miscarriage. (opendemocracy.net)
  • LSD and psilocybin mushrooms continue to be secondary drug problems in Maine while MDMA is just beginning to emerge. (justice.gov)
  • Whereas primary/organic TR (caused by a structural abnormality) is relatively infrequent, secondary or functional TR (caused by dilatation of the tricuspid annulus and remodelling of the right ventricle and right atrium) is the predominant cause, and isolated TR, associated with atrial fibrillation, is an emerging entity. (escardio.org)
  • Myotoxicity from drugs and toxins can result from a number of mechanisms, including direct injury to muscle cell membranes, organelles or proteins, through immunopathic processes, and as a result of secondary systemic effects, such as ischaemia and electrolyte disturbances. (musculoskeletalkey.com)
  • The efficacy of Ankaferd Blood Stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model. (egli-online.com)
  • Consequent to this, the child had developed raised IOP and steroid-induced secondary open-angle glaucoma with irreversible damage of the optic nerve in both eyes. (pediatriconcall.com)
  • Steroid-induced glaucoma is secondary glaucoma which can occur in any age group following corticosteroid administration by any route (topical, peri-ocular or systemic). (pediatriconcall.com)
  • Intravenous calcium gluconate is approved by the US Food and Drug Administration (FDA) for preventing hyperkalemia-induced cardiac abnormalities. (therapeuticresearch.com)
  • Intravenous calcium gluconate is FDA-approved for preventing hyperkalemia-induced cardiac abnormalities. (therapeuticresearch.com)
  • Hyperkalemia-induced Brugada ECG pattern is rare. (j-pcs.org)
  • 3] In this report, we have discussed a patient with rare ECG manifestation - hyperkalemia-induced Brugada phenocopy (BrP). (j-pcs.org)
  • In fact, blood tests commonly find liver function abnormalities after starting statins. (drmicozzi.com)
  • Abnormalities were found in two infants and a six-month old fetus born to women treated with Ledoxina. (sdrugs.com)
  • If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. (sdrugs.com)
  • The new law bans abortions sought because of a genetic abnormality of the fetus, except in medical emergencies. (hrwf.eu)
  • In light of cocaine's widespread use among pregnant women, the effect of the drug on the fetus is an issue of major public health importance. (medlink.com)
  • The enzyme deficiency in Gaucher patients results in hepatosplenomegaly, hematologic abnormalities, bone disease, and there is a 50-fold increased propensity for development of B cell lymphomas and multiple myeloma. (umaryland.edu)
  • There have been rare reports of oxcarbazepine resulting in the development of hematologic abnormalities, including agranulocytosis and aplastic anemia. (drugbank.com)
  • Elevated serum GGT was associated with the ventricular repolarization abnormalities in the early stage of T2DM [ 8 ]. (aging-us.com)
  • Repolarization abnormalities such as action potential (AP) prolongation and early afterdeploarizations (EAD) are often observed in vitro upon pharmacological interventions. (physiomeproject.org)
  • Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers , Corrias A, Giles W, Rodriguez B, 2011, American Journal of Physiology Heart and Circulatory Physiology , 2011 May;300(5):H1806-13. (physiomeproject.org)
  • Drug-induced PRCA is a rare blood disorder in adults and has already been reported in isoniazid-treated patients ( 3 - 5 ). (cdc.gov)
  • Patients taking any of the widely used nonsteroidal anti-inflammatory drugs (NSAIDs) should be aware that they all have clinically important interactions with many other medications. (worstpills.org)
  • Patients taking the oral antifungal drug itraconazole (SPORANOX, TOLSURA) should be aware that it has clinically important interactions with many other prescription medications that can affect the safety or effectiveness of itraconazole or the interacting drugs. (worstpills.org)
  • Patients taking the commonly prescribed abnormal heart rhythm drug amiodarone should be aware that it has clinically important interactions with many other prescription medications. (worstpills.org)
  • Patients taking the commonly used stomach-acid-suppressing drug omeprazole should be aware that it has clinically important interactions with many other prescription medications. (worstpills.org)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval. (nih.gov)
  • RÉSUMÉ La présente étude prospective de suivi visait à déterminer l'incidence et les facteurs de risque des maladies iatrogènes ainsi que leur évolution chez des patients admis en unité de soins intensifs pédiatriques d'un hôpital universitaire en Libye. (who.int)
  • With increasing global numbers of patients with pacemaker and defibrillator devices, the prevalence of lead-induced TR may increase considerably in the near future. (escardio.org)
  • ANZEMET Tablets are contraindicated in patients known to have hypersensitivity to the drug. (anzemet.com)
  • ANZEMET should be used with caution and with ECG monitoring in patients with underlying structural heart disease and pre-existing conduction system abnormalities, elderly patients, patients with sick sinus syndrome, patients with atrial fibrillation with slow ventricular response, patients with myocardial ischemia or those receiving drugs known to prolong the PR and QRS interval. (anzemet.com)
  • Patients should be informed of the increased risk of serotonin syndrome, especially if ANZEMET is used concomitantly with other serotonergic drugs such as medications to treat depression and migraines. (anzemet.com)
  • The fact that ICB-induced diabetes could be cured using infliximab "is of relevance because many patients undergoing ICB treatment for melanoma will have a long-lasting remission, and quality of life is therefore strongly influenced by side effects," Trinh and coauthors say. (medscape.com)
  • About 60% of patients with psychiatrist office visits leading to a drug prescription received at least two medications in 2005-2006, according to government survey data. (cchrint.org)
  • Here, we have generated induced pluripotent stem cells (iPSCs) from WD patients carrying compound heterozygous mutations on ATP7B . (biorxiv.org)
  • Skeletal muscle abnormalities impair the activities of daily living and the quality of life, which are major causes of the impairment of exercise tolerance and the poor prognosis of patients with HF ( 1 ). (frontiersin.org)
  • Second malignancies have developed in some patients treated with Ledoxina used alone or in association with other antineoplastic drugs and/or modalities. (sdrugs.com)
  • Cyclophosphamide-induced sterility may be irreversible in some patients. (sdrugs.com)
  • Spine Phila Pa Jun;18 8: ABS may be prophylactically administered to the gastric mucosa following biopsy in patients having gastric remnants, comorbid conditions associated with hemostatic deficiency ankagerd, chronic renal and liver failure and antihemostatic drug use eg, ASA, warfarin and clopidogrel. (egli-online.com)
  • 2 Studies describing systemic steroid-induced glaucoma have mostly focused on adults with only a few reports in pediatric patients 3,4,5 , although it constitutes one-fourth of all acquired glaucoma in children. (pediatriconcall.com)
  • Patients prone to this type of cataract can develop them as a result of the prolonged intake of these drugs. (hospitalochoa.com)
  • This form of EPS is caused by the pharmacologic effect of penicillamine (in only about 1% of the patients who were administered the drug). (sunsaferx.com)
  • Patients were randomized in a large, ongoing, postmarketing safety study had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs). (vfecto.com)
  • Be assured that we are working hard to make available soon some drug that can be given safely to patients to limit the damaging effects of high blood glucose and help prevent retinopathy, she says. (reviewofoptometry.com)
  • Although some molecularly targeted drugs for colorectal cancer are used clinically and contribute to a better prognosis, the current median survival of advanced colorectal cancer patients is not sufficient. (biomedcentral.com)
  • Although some molecularly targeted drugs, such as anti-vascular endothelial cell growth factor (VEGF) and anti-epidermal growth factor receptor (EGFR) antibodies, are used clinically and contribute to a better prognosis, the current median survival of stage IV colorectal cancer patients receiving chemotherapy is shorter than 3 years [ 2 ]. (biomedcentral.com)
  • This newer, coupled approach gives us hope that personalized cell therapies could be an important option for high-risk CLL patients on these types of drugs. (newswise.com)
  • All had abnormalities of TP53 or ATM - two mutations associated with high-risk disease - and two patients had increasing BTK C481S clones, also a high-risk marker. (newswise.com)
  • That first year on the drug may provide an optimal window to collect T cells from patients and subsequently administer a potentially curative T cell therapy, the authors said. (newswise.com)
  • WHIPPANY, N.J.--(BUSINESS WIRE)-- Bayer announced today the U.S. Food and Drug Administration (FDA) has approved a supplemental New Drug Application (sNDA) for the oral androgen receptor inhibitor (ARi) NUBEQA ® (darolutamide) with docetaxel for the treatment of adult patients with metastatic hormone-sensitive prostate cancer (mHSPC). (q4web.com)
  • The use of most CNS stimulants is contraindicated in patients with glaucoma, as these agents exhibit sympathomimetic activity and may induce mydriasis provoking an increase in intraocular pressure. (drugs.com)
  • A number of studies have found brain abnormalities in first-episode schizophrenia patients, and these findings have been seen as proof that the abnormalities must be due to the disease and not the treatment. (mindfreedom.org)
  • But as Moncrieff and Leo noted in their paper, many of the patients in the first-episode studies had been on antipsychotics for months, and there is evidence that antipsychotics may induce changes in brain structures in a short period of time. (mindfreedom.org)
  • Patients with myopathies induced by lipid-lowering drugs, including statins and fibrates, have an increased rate of genetic muscle disorders. (reliasmedia.com)
  • The recently published SPARCL study (reviewed in the previous article) will likely lead to a further increase in the number of patients treated with statins, and neurologists are increasingly likely to encounter patients suffering from statin-induced side effects, especially myopathy. (reliasmedia.com)
  • In this background, the paper by Vladutiu and colleagues is important because it found that 17 of 136 patients with muscle pain associated with use of lipid-lowering drugs, such as statins and fibrates, had one of 3 metabolic muscle disorders. (reliasmedia.com)
  • The work of Vladutiu et al suggests that susceptibility to the side effects of lipid-lowering drugs may have a genetic basis in some patients. (reliasmedia.com)
  • There is evidence, however, that some patients who have the genetic disorders associated with myopathies induced by lipid-lowering drugs respond to specific treatments, so some patients may actually benefit from identification of their defect. (reliasmedia.com)
  • Moreover, an awareness of the underlying genetic abnormalities may be important in counseling some patients and their families and, in the future, in developing and applying effective alternative treatments for the underlying muscle disorders and for hyperlipidemia. (reliasmedia.com)
  • Patients with a first recurrence of venous thromboembolism or with an initial episode with continuing risk factors either could be closely monitored for any early signs of thromboembolism or should be given anticoagulant drugs prophylactically after the period of initial therapeutic anticoagulation for the episode. (binary-options-guide.com)
  • I demonstrated that the combined assessment of electrical and mechanical abnormalities (alias the electromechanical window) in patients with the long-QT syndrome provide superior sudden cardiac death risk stratification than the traditionally used QTc. (carimmaastricht.nl)
  • both in drug-induced animal models and in patients with the long-QT syndrome. (carimmaastricht.nl)
  • Maintain careful prescription records, educate patients about abuse, monitor for signs of abuse and overdose, and periodically re-evaluate the need for XELSTRYM use [see WARNINGS AND PRECAUTIONS and Drug Abuse And Dependence ]. (rxlist.com)
  • Dangerous drugs have the capacity to cause users to suffer a remarkably wide range of different types of harm, and far too many of these products make it into patients' hands every year. (wmkylaw.com)
  • The U.S. Food and Drug Administration announced a decade later, however, that the drug appears to be linked to severe complications in patients, including an increased risk of heart failure or even death. (wmkylaw.com)
  • In doing so, T-cell checkpoint inhibitors can induce long-term responses in some patients with difficult-to-treat cancers, including melanoma, bladder cancer and nonsmall cell lung cancer. (ddw-online.com)
  • We also mention the potential therapeutic use of herbal drugs targeting AHR and ROS in patients with Yusho. (elsevier.com)
  • The blood vessels in the retina of the eye are abnormal in individuals with schizophrenia, according to the study "Microvascular Abnormality in Schizophrenia as Shown by Retinal Imaging" in the American Journal of Psychiatry . (psychnews.org)
  • On examination, the doctor hears auscultatory abnormalities: crackles which correspond to abnormal noises during inspiration. (cleverlysmart.com)
  • The abnormal slowing of the heart's rhythm (bradycardia) can also induce cardiac arrest. (aedusa.com)
  • Cardiovascular impairments - Aside from the more familiar abnormalities such as a bent valve, these uncommon situations are characterized by abnormal blood vessel structures. (aedusa.com)
  • Multiple genetic changes happening during carcinogenesis cause cell abnormalities. (gbic2012.org)
  • Genetic Risk Factors Associated with Lipid-Lowering Drug-Induced Myopathies. (reliasmedia.com)
  • As a practical matter, identification of a genetic basis for myopathy may not alter treatment at the moment because the main options, using alternative drugs, lowering doses of offending agents, and emphasizing strict diet control to lower lipids, would be tried even without the knowledge of an underlying genetic problem. (reliasmedia.com)
  • However, a fatty liver can also be caused by a genetic mutation or adverse reactions to drugs. (terpsichoresand.org)
  • Genetic factors for a sulfa drugs fda. (lapelpinzone.com)
  • Oct 19, · A review of the genetic and biochemical abnormalities associated with autism reveals a possible link between the widely diagnosed neurological disorder and Type 2 diabetes, another medical. (farkastanya.hu)
  • For this patient, other causes for anemia (e.g., drug-induced hemolytic anemia, digestive malignancies, viral causes known to date, hematologic malignancies, and autoimmune disorders) were excluded ( 2 ). (cdc.gov)
  • In addition to focal lesions such as strokes and tumors (1), causes include several degenerative movement disorders, such as progressive supranuclear palsy (PSP ) (94), SCA3 (Machado-Joseph disease) (95) (Figure "lid retraction" ), and lithium-induced parkinsonism (96). (neuroophthalmology.ca)
  • In addition to the many inherited disorders already described in this book, nerves and muscles can be affected by a wide range of drugs and toxins. (musculoskeletalkey.com)
  • That is of particular concern because some of the drugs may predispose to psychiatric disorders later in life," says lead author Patrick Forcelli. (cchrint.org)
  • Multiple electrode aggregometry (MEA) has been shown to detect von Willebrand disease (VWD), platelet function disorders, and drug-induced bleeding disorders. (gentaur.se)
  • In South Australia, reporting of all births, induced termination of pregnancy (ITOP) procedures and congenital abnormalities to the Pregnancy Outcome Unit (POU) of the South Australian Department for Health and Ageing is mandated, 28 and form the Birth Defects Register surveillance system. (who.int)
  • A Single Pediatric CT Scan Raises Brain Cancer Risk For every 10,000 children who received one head CT examination, about one radiation-induced brain cancer is expected during the 5-15 years following the CT examination, researchers warn. (medscape.com)
  • Knowing which drugs prescribed or recommended by your doctor can cause sexual dysfunction will allow you to take steps to prevent or minimize this common, often troubling adverse drug effect. (worstpills.org)
  • Three of the four children with laboratory evidence of drug-induced platelet dysfunction had abnormalities on MEA. (gentaur.se)
  • Skeletal muscle abnormalities (mitochondrial dysfunction and muscular atrophy/muscular weakness) in heart failure and sarcopenia are associated with fat accumulation and abnormalities of adipokines caused by an unhealthy lifestyle, leading to reduced exercise tolerance, and a poor prognosis. (frontiersin.org)
  • Erectile dysfunction (ED) is a common side effect of a number of prescription drugs. (clevelandclinic.org)
  • What prescription drugs may cause erectile dysfunction? (clevelandclinic.org)
  • Drug Induced Erectile Dysfunction Icd 10 waved his hand to enzyte at cvs for the screenwriter Kim Looking at Jin Xianjun, Moon Jeongyou paused for a Test Booster Elite his smile You cant talk nonsense I didnt grab someones role. (carrozzeriasgarbossafabris.com)
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  • Researchers found that when given to infant rats, the drugs caused behavioral abnormalities later in life. (cchrint.org)
  • Type 2 diabetes was induced in Wistar rats by single i.p. administration of streptozotocin (50 mg/kg). (japtr.org)
  • 1989. Hexachlorobenzene-induced hyperthyroidism and osteosclerosis in rats. (cdc.gov)
  • PATAS can correct the metabolic abnormalities leading to type 2 diabetes and its associated comorbidities which include insulin resistance [1] . (inserm.fr)
  • Now that we're about halfway through 2019, it's a good time to check your cabinets and throw out any expired drugs or supplements. (drmicozzi.com)
  • The U.S. Food and Drug Administration approved Vumerity in October 2019, and the drug has since has become the top prescribed oral MS therapy in the U.S. Vumerity also is approved in the U.K. and Switzerland. (chemrobotics.in)
  • VUMERITY was first approved by the U.S. Food and Drug Administration in October 2019 and is also approved in Great Britain and Switzerland. (chemrobotics.in)
  • On Oct. 18, 2019, manufacturer Sanofi announced a voluntary recall of its over-the-counter brand-name heartburn drug Zantac due to it containing N-Nitrosodimethylamine (NDMA) which may cause cancer in humans. (wmkylaw.com)
  • To avoid the controversy surrounding these cells, scientists around the world have explored reprogramming mature cells to make them just as potent, with the hope being that such induced pluripotent stem (iPS) cells might one day help replace diseased or damaged tissue. (scientificamerican.com)
  • Our laboratory is using human induced pluripotent stem cells (iPSC) for disease modeling and drug discovery. (umaryland.edu)
  • This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
  • Zika infection during pregnancy or around the time of birth can cause severe congenital microcephaly, a condition in which a baby's head is smal er than expected, as well as other serious brain abnormalities. (cdc.gov)
  • Occasional reports of drug-induced delayed and myocardial infarction. (lapelpinzone.com)
  • We reported a case of drug-induced lung injury associated with mesalazine. (greenmedinfo.com)
  • And while you're at it, you should also take the time to throw out any drugs or supplements that can cause liver injury. (drmicozzi.com)
  • Which explains why drugs are the No. 1 cause of liver injury and death. (drmicozzi.com)
  • Plus, drug-induced liver injury (DILI) is the leading reason why a medication is taken off the market after it's been approved. (drmicozzi.com)
  • Why doesn't the U.S. Food and Drug Administration study liver injury more closely during the initial approval process of these drugs? (drmicozzi.com)
  • But, compared to prescription drugs, dietary supplements are still a minor source of injury-occurring in just three out of every 100,000 people. (drmicozzi.com)
  • The role of the early growth response-1 (EGr-1) transcription factor is thought to be essential for ethanol-induced fatty liver injury in mice. (medscape.com)
  • Drug-induced liver injury (DILI) is a term that describes abnormalities in liver function tests related to medication intake. (univr.it)
  • However, the full extent of the risk of nimesulide-induced liver injury is still a much debated issue within the EMEA. (univr.it)
  • If drug-induced liver injury is suspected, the administration of Pfizer-BioNTech COVID-19 Vaccine The Pfizer-BioNTech COVID-19. (squabash.com)
  • Injury to a woman's physical or mental health is broad enough to include circumstances such as pregnancy induced depression, and being unable to bear the financial responsibility of caring for a child. (opendemocracy.net)
  • In mice with OIR and laser injury-induced CNV, eyes treated with a single intravitreal injection of dasatinib exhibited significant decreases in pathological neovascularization compared with that of controls injected with vehicle. (molvis.org)
  • changes were also prevented by administering cyclophosphamide, a drug which in low dose might inhibit proliferation of suppressor lymphocyte populations. (deepdyve.com)
  • Therefore, information on the potential of herbal medicines to inhibit or induce the activity or expression of drug-metabolizing enzymes when co-administered with conventional drugs is important. (jkom.org)
  • Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities. (freepatentsonline.com)
  • Upper and lower digestive tract endoscopic examination and carcinoembryonic antigen showed no abnormalities, which lessened the likelihood of a tumor relapse. (cdc.gov)
  • The tumors developed in mice model injected with glioblastoma stem cells (GSCs) display high extensive migratory and infiltrative capacity, indicating that isolated brain tumor stem cells in vivo may induce tumor to the brain similar to those observed in glioblastoma multiforme [ 7 , 14 , 15 ]. (hindawi.com)
  • Pfizer Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for XELJANZ® / XELJANZ® XR (tofacitinib) for the treatment of adults with active ankylosing spondylitis (AS) who have had an inadequate response or intolerance to one or more tumor necrosis factor (TNF) blockers. (pharmafocusasia.com)
  • The use of a specific type of natural killer cells instead of pluripotent cells is much less likely to induce the formation of a tumor. (medindia.net)
  • And according to the DILI reporting network, research links 3.4 percent of all drug-induced liver injuries to statins. (drmicozzi.com)
  • [ 5 ] Other therapies used outside of pregnancy, such as complementary and alternative therapies and biologic drugs ( e.g. , monoclonal antibodies), have unclear and/or mixed safety profiles during pregnancy and lactation. (medscape.com)
  • Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins. (who.int)
  • Maternal cocaine abuse during pregnancy is common and is associated with a host of neurologic and developmental abnormalities in the offspring. (medlink.com)
  • Anesthesiologists should understand both physiological changes in the coagulation system and diseaseand medication-induced pathophysiological changes during pregnancy and increase the safety of regional anesthesia for painless delivery and cesarean section. (anesth-pain-med.org)
  • or where there is substantial risk that if the pregnancy were carried to term the child would suffer from or later develop a serious physical abnormality or disease. (opendemocracy.net)
  • Chronic diseases, including heart failure (HF), are often accompanied with skeletal muscle abnormalities in both quality and quantity, which are the major cause of impairment of the activities of daily living and quality of life. (frontiersin.org)
  • Chronic diseases, particularly heart failure (HF), cause qualitative and quantitative abnormalities, not only in the target organ but also in distant organs, such as the skeletal muscle ( 1 , 2 ). (frontiersin.org)
  • Some of the examples of how the mechanistic understanding of epigenetics can potentially aid drug discovery in eye diseases can be: 1) Latent infection of HSV1 (Herpes Simplex Virus 1) in corneal cells can lead to persistent recurrence of keratitis ( 3 ). (frontiersin.org)
  • Clopidogrel is a widely prescribed drug in cardiac and extracardiac vascular diseases. (ijp-online.com)
  • Herbal medicines have been used for the treatment of a multitude of diseases, and are often used in conjunction with conventional drugs. (jkom.org)
  • This can be done by giving immunosuppressive drugs such as corticosteroids in forms associated with particular autoimmune diseases. (cleverlysmart.com)
  • Importantly, recombinant GCase, which is used in enzyme replacement therapy (ERT), and drugs used in substrate reduction therapy (SRT) reverse these phenotypes, showing the utility of this patient-derived iPSC system to evaluate the therapeutic efficacy of new agents in the treatment of sphingolipidoses. (umaryland.edu)
  • Genita Petralli, president of nonprofit Green Body and Mind, director of Patient Services at Alternative to Meds Clinic, and an author of several books, says it's her mission to "educate all those interested in what is causing the epidemic mental health crisis of today, how to avoid it, how to get off psychiatric drugs if you are on them now, and why toxic drugs should not ever be called medicine. (cchrint.org)
  • Among protocol-specified adverse events occurred in one patient each in the U. Food and Drug Administration (FDA), but has been excluded. (squabash.com)
  • Does this patient have drug-induced lupus? (dermatologyadvisor.com)
  • Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. (freepatentsonline.com)
  • Case report of patient with carisoprodol overdose who developed coma, but had no liver abnormalities). (nih.gov)
  • Pharmacotherapeutic group of adverse drug called a patient and may be instituted for, shigellosis, eosinophilia. (lapelpinzone.com)
  • Drugs such as charas and ganja, along with opium and alcohol, 'are of so noxious a quality, and produce a species of intoxication so extremely violent,' he warned, 'that they cannot be used without imminent danger to the individual as well as to the public. (druglibrary.org)
  • Some drug-related myopathies, such as those caused by statins, steroids and alcohol, are common, while others are very rare. (musculoskeletalkey.com)
  • 84 ). A pregnant woman who abuses cocaine may also drink alcohol, smoke cigarettes, and abuse other illicit drugs. (medlink.com)
  • It can be induced by excessive alcohol consumption and exacerbated by obesity. (terpsichoresand.org)
  • The syndrome also can be caused by certain other drugs used to treat nausea and depression, as well as by the sudden discontinuation of a dopamine agonist (drugs that are used most commonly to treat Parkinson's disease). (worstpills.org)
  • Certainly, the primary action of antipsychotic drugs is to diminish dopamine D2 receptor-mediated neurotransmission. (researchgate.net)
  • Such regionally specific neuronal abnormalities probably underlie negative features and cognitive deficits, as well as contributing to a disinhibition of subcortical dopamine. (researchgate.net)
  • Many neurotransmitters, including gamma-aminobutyrric acid (GABA), glutamate, acetylcholine, dopamine, serotonin and endogenous opioid peptides, have been implicated in the effects of the various drugs of abuse. (uninsubria.it)
  • There is, in addition, a growing body of evidence that the endogenous cannabinoid system might participate in the motivational and dopamine-releasing effects of several drugs of abuse. (uninsubria.it)
  • It usually occurs as part of a syndrome that involves other abnormalities and requires multidisciplinary treatment. (wikipedia.org)
  • Serotonin syndrome has been reported with 5-HT 3 , receptor antagonists alone (with overdose) but particularly with concomitant use of serotonergic drugs. (anzemet.com)
  • Serotonin syndrome has been described following the concomitant use of 5-HT 3 receptor antagonists and other serotonergic drugs, including SSRIs and SNRIs. (anzemet.com)
  • Hormones & Endocrine abnormality - Cushing syndrome, acromegaly etc. (medihelp365.com)
  • Consider drugs in blood supply of serotonin syndrome, and subsequently, with the great and multiply within the diagnosis will try to prepare one's practice to adverse events. (refrigeratordealers.com)
  • The scientists had shown that adipose tissue abnormalities caused by a dysfunctional protein called ALMS1 led to extremely severe insulin resistance associated with early-onset type 2 diabetes in people with Alström syndrome. (inserm.fr)
  • SABCS 2022 T-DXd: 'Remarkable' Survival Gains in Advanced Breast Cancer The antibody-drug conjugate trastuzumab deruxtecan continues to show impressive progression-free and overall survival gains in previously treated unresectable and/or metastatic HER2+ breast cancer. (medscape.com)
  • If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included. (worstpills.org)
  • 1 Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism. (drugbank.com)
  • Besides, llc, cellulitis, drug interactions may also been shown to sulfa antibiotics are coadministered with certain diuretics. (ctsvaz.cz)
  • As I've explained before, pharmaceutical companies add this poison to hundreds of prescription drugs and over-the-counter medications. (drmicozzi.com)
  • There are several hypotheses about the mechanisms by which calcium antagonists induce gingival hyperplasia, but further investigation is still needed. (medscape.com)
  • Decreased production of neutrophils is associated with deficiencies of vitamin B12 and folic acid , aplastic anemia , tumors , drugs, metabolic disease, nutritional deficiency and immune mechanisms. (wikipedia.org)
  • Drugs and toxins have also provided useful paradigms of muscle disease and have helped to elucidate cellular mechanisms. (musculoskeletalkey.com)
  • Many mechanisms of ethanol-induced fatty liver have been proposed. (medscape.com)
  • However, because drugs do not act on only one defined target, it is often difficult to fully explain the mechanisms of action and their potential arrhythmogenicity. (physiomeproject.org)
  • Computational models, when appropriately detailed and validated, can be used to gain mechanistic insights into the mechanisms of action of certain drugs. (physiomeproject.org)
  • This review will discuss the latest advances on the mechanisms of cannabinoid dependence and the possible role of the endocannabinoid system in the treatment of addiction, not only to marijuana but also to the other common illicit drugs. (uninsubria.it)
  • GCase deficiency results in the accumulation of glucosylsphingolipids, leading to phenotypic abnormalities in a number of cell types, including macrophages, neuronal cells, osteoblasts, and hematopoietic cells. (umaryland.edu)
  • What's more, the abnormalities were not limited to the drugs known to cause neuronal cell death. (cchrint.org)
  • a primary hemostatic disorder was detected in 35 children (VWD (n = 16), platelet disorder (n = 15), and valproic acid therapy-induced bleeding disorder (n = 3), acetylsalicylic acid-related bleeding (n = 1). (gentaur.se)
  • A potentially life-threatening disorder which is commonly drug-induced. (drstevenleibowitz.com)
  • Drug dependence is a chronically relapsing disorder, manifested as an intense desire for the drug, with impaired ability to control the urges to take the drug, even at the expense of serious adverse consequences. (uninsubria.it)
  • The activation of insulin in the adipocytes induces the separation of these two proteins ALMS1 and PKC alpha, resulting in glucose entry into cells. (inserm.fr)
  • The large increase in the number of Maine treatment admissions for opiate addiction during 1999 and 2000--excluding those resulting from heroin abuse--is an indicator of the extent of the prescription drug problem. (justice.gov)
  • The total number of clients admitted to drug treatment programs for opiate abuse--excluding heroin--has risen rapidly, outpacing the percentage increases in all other types of drug addiction admissions in Maine. (justice.gov)
  • Prior to the development of anti-TB drugs in the middle of the 20th century, good food, open air, a dry climate and rest constituted the main treatment for TB, and those who could afford it would retreat to sanatoriums. (indianewengland.com)
  • The anti-inflammatory agent infliximab ( Remicade , Janssen) could be a novel treatment for immune checkpoint inhibitor-induced diabetes, a single case study suggests. (medscape.com)
  • We report the first successful treatment, to our knowledge, of an ICB-induced [diabetes] with infliximab. (medscape.com)
  • The Food and Drug Administration has given methotrexate indications for the treatment of psoriasis, rheumatoid arthritis, and juvenile rheumatoid arthritis. (escholarship.org)
  • This is providing new targets for antipsychotic drug treatment. (researchgate.net)
  • ing new targets for antipsychotic drug treatment. (researchgate.net)
  • It may be necessary for you to stop treatment for awhile, or to change to a different nonsteroidal antiinflammatory drug before your procedure. (cfm.org.br)
  • Osteoporosis: Evaluate serial BMD at baseline and every 1-3 years during treatment then every 2-4 years during a drug holiday. (mims.com)
  • Therefore, dasatinib may be indicated for the treatment of ischemia-induced proliferative retinopathy and neovascular age-related macular degeneration. (molvis.org)
  • The ear nose throat (ENT) examination ruled out abnormality (dryness, atrophy, or infection) of buccal mucosa and cranial nerve lesion. (ijp-online.com)
  • Respiratory System Abnormalities" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Congenital structural abnormalities of the respiratory system. (harvard.edu)
  • This graph shows the total number of publications written about "Respiratory System Abnormalities" by people in Harvard Catalyst Profiles by year, and whether "Respiratory System Abnormalities" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Respiratory System Abnormalities" by people in Profiles. (harvard.edu)
  • Early respiratory abnormalities in emergency services police officers at the World Trade Center site. (cdc.gov)
  • Cocaine is one of the most addictive and frequently abused illicit drugs. (medlink.com)
  • Cocaine can interact with the monoaminergic synapses in the developing brain to induce short-term and long-term changes in neurophysiology and anatomy. (medlink.com)
  • Limitation of Use: Use of OLUMIANT in combination with other JAK inhibitors, biologic disease-modifying antirheumatic drugs (DMARDs), or with potent immunosuppressants such as azathioprine and cyclosporine is not recommended. (lilly.com)
  • To identify developmental nephrotoxic drugs in a large scale, we established and performed an automated high-content screen to score for phenotypic renal alterations in the Tg(wt1b:EGFP) zebrafish line. (biorxiv.org)
  • 10 , 11 , 12 It is a structural derivative of carbamazepine 8 and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name eslicarbazepine . (drugbank.com)
  • Given the ongoing worldwide HIV pandemic and the increase in tuberculosis it induces, such adverse effects are more likely to be reported in the next few years. (cdc.gov)
  • One case each of drug-induced fever and transient diarrhea were observed in Regimen B. These adverse effects disappeared after the cessation of therapy. (elsevier.com)
  • In, Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. (nih.gov)
  • The secretion of the growth factors is induced by the HLA-G molecules on the natural killer cells. (medindia.net)
  • As Src, a non-receptor tyrosine kinase, has been implicated as one of the major signaling molecules in VEGF-mediated neovascularization, the present study aimed to investigate whether dasatinib, a potent Src kinase inhibitor, could suppress pathological ocular neovascularization in murine models of oxygen-induced retinopathy (OIR) and choroidal neovascularization (CNV). (molvis.org)
  • Among the various VEGF-induced signal transduction molecules, Src, a non-receptor tyrosine kinase, is a key component in angiogenic signaling cascades. (molvis.org)
  • Spirometric abnormalities associated with chronic bronchitis, asthma, and airway hyperresponsiveness among boilermaker construction workers. (cdc.gov)
  • When mydriasis is induced by an anticholinergic drug such as atropine, instillation of full-strength pilocarpine (1% or more) will not reverse the mydriasis. (aao.org)
  • About 10% of tested drugs induced pronephric phenotypes including glomerular and tubular malformations, or overall changes in kidney morphology. (biorxiv.org)
  • During the 1990s, the role of amniotic membrane transplantation in treating a variety of ocular surface defects and abnormalities has been revived. (drstevenleibowitz.com)
  • Abnormalities or defects in Bruch's membrane induce hypoxia, oxidative stress, and inflammation, which disturb the balance of pro- and antiangiogenic factors in the direction of angiogenesis. (molvis.org)
  • We have shown that skeletal muscle abnormalities are a hallmark of HF, in which metabolic pathways involving phosphocreatine and fatty acids are largely affected. (frontiersin.org)
  • Summary of the association between skeletal muscle abnormalities and heart failure. (frontiersin.org)
  • NSAIDs represent one of the most widely used classes of drugs. (univr.it)
  • At baseline, age, diuretic use and presence of other rest electrocardiographic abnormalities were significantly associated with the prevalence of VPCs. (umn.edu)
  • This was due to an increasing risk among the SI group, and the risk was independent of the presence or absence of rest electrocardiographic abnormalities at baseline. (umn.edu)
  • a Critical Images slideshow, to help identify the causes of abnormalities of the oral cavity. (medscape.com)
  • Disopyramide Phosphate is an antiarrhythmic drug available for oral administration in capsules containing 100 mg or 150 mg of disopyramide base, present as the phosphate. (nih.gov)
  • Oral calcium carbonate is approved by the US Food and Drug Administration (FDA) as an antacid. (therapeuticresearch.com)
  • In children whose disease fails to respond adequately to appropriate adrenocorticosteroid therapy or in whom the adrenocorticosteroid therapy produces or threatens to produce intolerable side effects, Ledoxina may induce a remission. (sdrugs.com)
  • The first lesson is that hematologic malignancies, and all other cancers for that matter, tend to come back (relapse) even after complete remission induced by cytotoxic chemotherapy . (greenmedinfo.com)
  • Tube formation, scratch wounding migration, and cell proliferation assays were performed to measure the inhibitory effect of dasatinib on VEGF-induced angiogenesis in human retinal microvascular endothelial cells. (molvis.org)