Androstenols: Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.Phenylthiohydantoin: Thiohydantoin benzene derivative.Steroid 17-alpha-Hydroxylase: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.Orchiectomy: The surgical removal of one or both testicles.Prostatic Neoplasms, Castration-Resistant: Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Castration: Surgical removal or artificial destruction of gonads.Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Acetates: Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.Neoplasms, Hormone-Dependent: Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Androgen Receptor Antagonists: Compounds that bind to and inhibit the activation of ANDROGEN RECEPTORS.Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.Biosynthetic Pathways: Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.Tissue Extracts: Preparations made from animal tissues or organs (ANIMAL STRUCTURES). They usually contain many components, any one of which may be pharmacologically or physiologically active. Tissue extracts may contain specific, but uncharacterized factors or proteins with specific actions.Clinical Trials, Phase III as Topic: Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.Budgets: Detailed financial plans for carrying out specific activities for a certain period of time. They include proposed income and expenditures.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Acetate Kinase: An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)African Americans: Persons living in the United States having origins in any of the black groups of Africa.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Puma: A genus in the family FELIDAE comprising one species, Puma concolor. It is a large, long-tailed, feline of uniform color. The names puma, cougar, and mountain lion are used interchangeably for this species. There are more than 20 subspecies.Transducers: Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Pan American Health Organization: WHO regional office for the Americas acting as a coordinating agency for the improvement of health conditions in the hemisphere. The four main functions are: control or eradication of communicable diseases, strengthening of national and local health services, education and training, and research.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Galactogogues: Substances that induce LACTATION.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.IndiaCommerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone. *5α-Androstane ... cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ... cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) ... cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate) ... medroxyprogesterone acetate, megestrol acetate, and hydroxyprogesterone caproate, as well as the atypical agent danazol.[75] ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ... cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) ... Shields-Botella, J.; Chetrite, G.; Meschi, S.; Pasqualini, J.R. (2005). "Effect of nomegestrol acetate on estrogen biosynthesis ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ... cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) ... cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate) ... Estradiol esters (e.g., estradiol acetate, estradiol benzoate, estradiol cypionate, estradiol enanthate, estradiol undecylate, ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ... cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) ... norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and noretynodrel, while the gonanes include ... norethindrone acetate, ethynodiol diacetate) are converted to this parent compound. Norethindrone is the second most commonly ...
Steroidal antiandrogens include compounds like cyproterone acetate, spironolactone, estradiol, abiraterone acetate, and ... Abiraterone acetate. Steroidal. Androgen synthesis inhibitor. Zytiga. Oral. 2011. Available. 523,000 Allylestrenol. Steroidal. ... medroxyprogesterone acetate, megestrol acetate, osaterone acetate (veterinary), and oxendolone,[74][75] and estrogens like ... megestrol acetate, chlormadinone acetate, spironolactone, oxendolone, and osaterone acetate (veterinary) and the nonsteroidal ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ... These include Delalutin, Chlormadinone acetate, and PH-218. It would appear that decreased androgen production is a property ... though not as potently as cyproterone acetate.[3] The drug has also been found to suppress androgen production, likely via ... Similarly to the structurally related steroid cyproterone acetate, edogestrone binds directly to the androgen receptor and ...
A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Patients with ... A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Asymptomatic ... Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer; final overall survival analysis of the ... "Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ...
Progesterone derivatives: Medroxyprogesterone acetate. *Megestrol acetate. *Others/unsorted: 3-Keto-5α-abiraterone ...
Abiraterone acetate. Steroidal. Androgen synthesis inhibitor. Zytiga. Oral. 2011. 523,000. Allylestrenol. Steroidal. Progestin ... cyproterone acetate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate, osaterone acetate (veterinary), and ... cyproterone acetate, gestonorone caproate,[120] medroxyprogesterone acetate, megestrol acetate, and oxendolone.[2][121][122] ... megestrol acetate, chlormadinone acetate, spironolactone, oxendolone, and osaterone acetate (veterinary) and the nonsteroidal ...
Abiraterone acetate Aminoglutethimide Levoketoconazole "Ketoconazole". Merriam-Webster Dictionary. "Ketoconazole". Dictionary. ...
Abiraterone acetate inhibits an enzyme known as CYP17, which is used in the body to produce testosterone. The most successful ... Abiraterone acetate was FDA approved in April 2011 for treatment of castration-resistant prostate cancer for patients who have ... Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven". J Clin Oncol. 26 (14 ... As noted above, abiraterone is showing some promise in treating advance-stage prostate cancer. It causes a dramatic reduction ...
... may be effective in a subset of prostate cancer patients with acquired resistance to abiraterone acetate. ... Pinto Á (February 2014). "Beyond abiraterone: new hormonal therapies for metastatic castration-resistant prostate cancer". ... "Abiraterone and other novel androgen-directed strategies for the treatment of prostate cancer: a new era of hormonal therapies ...
Abiraterone acetate Amphenone B Rogletimide Glutethimide Ketoconazole Gross BA, Mindea SA, Pick AJ, Chandler JP, Batjer HH ( ...
Abiraterone Acetate and Enzalutamide". Clin Pharmacokinet. 55 (11): 1369-1380. doi:10.1007/s40262-016-0403-6. PMC 5069300 . ...
Johnson in 2009 based solely on abiraterone acetate. This drug was not yet in phase III clinical trials for its application in ...
The CYP17A1 inhibitors that have been marketed, like abiraterone acetate, are used mainly in the treatment of prostate cancer. ... Examples of CYP17A1 inhibitors include the older drug ketoconazole and the newer drugs abiraterone acetate, orteronel, ...
Similarly to abiraterone acetate, seviteronel has also been found to act to some extent as an antagonist of the androgen ... Seviteronel is 58-fold more selective for inhibition of 17,20-lyase than abiraterone, which has IC50 values for inhibition of ... In addition, in in vitro models, seviteronel appears to possess greater efficacy as an antiandrogen relative to abiraterone. ... results in less interference with corticosteroid production relative to the approved CYP17A1 inhibitor abiraterone acetate ( ...
Tan PS, Haaland B, Montero AJ, Kyriakopoulos CE, Lopes G (2014). "Hormonal Therapeutics Enzalutamide and Abiraterone Acetate in ... "AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer". New England Journal of Medicine. 371: 1028-38. doi: ...
In April 2011, the United States Food and Drug Administration approved Abiraterone Acetate (Zytiga), Cougar's lead product, for ...
Abiraterone acetate binds in the active site of the enzyme and coordinates the heme iron through its pyridine nitrogen, ... The drug abiraterone acetate, which is used to treat castration-resistant prostate cancer, blocks the biosynthesis of androgens ... Abiraterone is structurally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and ... Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to ...
Abiraterone acetate Ketoconazole Seviteronel Aminoglutethimide Alfatradiol Dutasteride Epristeride Finasteride Saw palmetto ... 17α-Hydroxyprogesterone derivatives Chlormadinone acetate Cyproterone acetate Megestrol acetate Osaterone acetate 19- ... chlormadinone acetate, cyproterone acetate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate) List of ... Norprogesterone derivatives Nomegestrol acetate 19-Nortestosterone derivatives Dienogest Oxendolone 17α-Spirolactone ...
Abiraterone acetate. *Alestramustine. *Almestrone. *Anabolic steroids (e.g., testosterone and esters, methyltestosterone, ...
Abiraterone acetate is the C3β acetate ester of abiraterone. In the early 1990s, Mike Jarman, Elaine Barrie, and Gerry Potter ... Abiraterone acetate, also known as 17-(3-pyridinyl)androsta-5,16-dien-3β-ol acetate, is a synthetic androstane steroid and a ... Abiraterone acetate was approved by the United States Food and Drug Administration on April 28, 2011. The FDA press release ... Abiraterone acetate is licensed by the European Medicines Agency. Until May 2012 the National Institute for Health and Clinical ...
This page contains brief information about abiraterone acetate and a collection of links to more information about the use of ... Abiraterone acetate is approved to be used with prednisone to treat:. *Prostate cancer that has metastasized (spread to other ... More About Abiraterone Acetate. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for ... This page contains brief information about abiraterone acetate and a collection of links to more information about the use of ...
Definition of abiraterone acetate. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... abiraterone acetate. Definition: An inhibitor of 17 alpha-hydroxylase/C17,20 lyase, an enzyme involved in androgen synthesis; ...
Business, life sciences, and technology news - covering Boston, Seattle, San Diego, Detroit/Ann Arbor, San Francisco, New York, Raleigh-Durham, Boulder/Denver, Texas, Wisconsin, Indiana, and beyond.. © 2007-2019, Xconomy, Inc. Xconomy is a registered service mark of Xconomy, Inc. All rights reserved.. Website development support from Andrew Koyfman with design support from Rob Hunter. ...
Professional guide for Abiraterone Acetate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse ... Abiraterone acetate is hydrolyzed to the active metabolite abiraterone; further metabolized to inactive metabolites abiraterone ... Note: Abiraterone acetate is available in different tablet formulations; use caution when selecting dosage form as dosing and ... Spironolactone: May diminish the therapeutic effect of Abiraterone Acetate. Monitor therapy. St Johns Wort: May decrease the ...
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for ... Androgen deprivation therapy, such as leuprolide acetate, prednisone, and abiraterone acetate may lessen the amount of androgen ... abiraterone acetate (abiraterone), prednisone, and apalutamide to see how well this combination works compared with ... Abiraterone acetate is a drug that blocks the remaining or residual male sex hormones in the body that may be helping prostate ...
Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal CYP17A1 inhibitor ... Retrieved from "https://www.SNPedia.com/index.php?title=Abiraterone_acetate&oldid=1320951" ...
Abiraterone Acetate. Participants were given Abiraterone Acetate 1000 milligram (mg) (4*250 mg) tablets and Prednisone 5 mg (2* ... Abiraterone Acetate. Participants were given Abiraterone Acetate 1000 milligram (mg) (4*250 mg) tablets and Prednisone 5 mg (2* ... IMAAGEN: Impact of Abiraterone Acetate in Prostate-Specific Antigen. The safety and scientific validity of this study is the ...
Abiraterone Acetate is used along with prednisolone (corticosteroid) for treating a type of prostate cancer called metastatic ... General Information on Abiraterone Acetate. Generic Name : Abiraterone Acetate Pronunciation : A-bir-A-ter-one AS-e-tate. ... Why is Abiraterone Acetate Prescribed? (Indications) Abiraterone acetate is used along with prednisolone (corticosteroid) for ... What are the side effects of Abiraterone Acetate? ♦ Most Common: Joint swelling, fracture, liver impairment, decrease in blood ...
... abiraterone acetate 250 mg as a generic of Janssens prostate cancer drug Zytiga (abiraterone). Janssen earned approximately $ ... abiraterone acetate 250 mg as a generic of Janssens prostate cancer drug Zytiga (abiraterone). ...
Drug: Abiraterone Acetate Abiraterone acetate 1000 mg orally daily (supplied as four 250 mg tablets) and prednisone 5 mg orally ... Experimental: Abiraterone Acetate Abiraterone acetate 1000mg orally daily until the time of disease progression, in the absence ... Willing to take abiraterone acetate on an empty stomach; no food should be consumed at least two hours before and for at least ... Abiraterone Acetate Trial in African American Prostate Cancer Patients. This study has been terminated. ...
Survival for Patients with Metastatic Advanced Prostate Cancer Results observed in patients treated with abiraterone acetate ... About Abiraterone Acetate. Abiraterone acetate is a novel, targeted, investigational, oral androgen biosynthesis inhibitor ... Treatment with abiraterone acetate resulted in a 35 percent reduction in the risk of death (HR=0.65; 95 percent CI: 0.54, 0.77 ... "Abiraterone acetate has the potential to meet a significant unmet need, so this news will be incredibly important to prostate ...
Get latest & updated abiraterone acetate prices in Chennai for your buying requirement. ... Find the top abiraterone acetate dealers, traders, distributors, wholesalers, manufacturers & suppliers in Chennai, Tamil Nadu ... Abiraterone Acetate Tablets (Zytiga)- Multum, Abiraterone Acetate Tablets (Zytiga)- Fda Business Type:. Distributor and ... Abirapro Abiraterone Acetate Tablet. Our organization is vastly engaged in exporting, distributing and supplying a supreme ...
Find all the information about Abiraterone Acetate (CB7630) for cell signaling research. ... Abiraterone Acetate (CB 7630) is a highly active and selective 17α-hydroxylase/17,20 lyase (CYP17A1) inhibitor with an IC50 of ... buy Abiraterone Acetate , Abiraterone Acetate supplier , purchase Abiraterone Acetate , Abiraterone Acetate cost , Abiraterone ... Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM ...
Abiraterone Acetate for Nonmetastatic Castration-Resistant Prostate Cancer, The Forgotten Dance Partner?, rising prostate- ... Abiraterone Acetate for nmCRPC, The Forgotten Dance Partner? - Zach Klaassen and Chris Wallis. ... "Abiraterone Acetate for Nonmetastatic Castration-Resistant Prostate Cancer, The Forgotten Dance Partner?" They reference recent ...
Is abiraterone acetate well tolerated and effective in the treatment of castration-resistant prostate cancer? [Nat Clin Pract ... CYP17 blockade by abiraterone acetate is safe and has significant antitumor activity in CRPC. These data confirm that CRPC ... To evaluate this, a trial of abiraterone acetate-a potent, selective, small-molecule inhibitor of cytochrome P (CYP) 17, a key ... Abiraterone acetate was well tolerated. The anticipated toxicities attributable to a syndrome of secondary mineralocorticoid ...
... abiraterone acetate) approved by the FDA to treat metastatic castration-resistant prostate cancer; will be commercialized by ... YONSA® was shown in clinical studies to be an effective form of abiraterone acetate, and can be taken with or without food, in ... Sun Pharma Announces USFDA Approval of YONSA® (abiraterone acetate) To Treat Metastatic Castration-Resistant Prostate Cancer In ... About YONSA® (abiraterone acetate) tablets YONSA® is a CYP17 inhibitor which uses proprietary SoluMatrix Fine Particle ...
BTG plc: ZYTIGA™ (abiraterone acetate) Approved in the US. BTG plc: ZYTIGA™ (abiraterone acetate) Approved in the US. 03 May ... About ZYTIGA (abiraterone acetate). ZYTIGA (abiraterone acetate) was developed by Ortho Biotech Oncology Research & Development ... Exposure of abiraterone increases up to 10-fold when abiraterone acetate is taken with meals. No food should be eaten for at ... ZYTIGA™ (abiraterone acetate) Receives FDA Approval for Treatment of Metastatic Prostate Cancer After Priority Review; First ...
... clinicaltrials.gov The purpose of this research study is to determine the effects of abiraterone acetate plus leuprolide ... abiraterone acetate plus leuprolide acetate and prednisone versus leuprolide acetate alone on hormone levels in the blood and ... abiraterone acetate plus leuprolide acetate plus prednisone, leuprolide acetate. Location. Dana-Farber Cancer Institute. Boston ... Neoadjuvant Abiraterone Acetate Plus Leuprolide Acetate in Men With Localized High Risk Prostate Cancer. 2014-08-27 03:21:19 , ...
The addition of abiraterone acetate plus prednisone to androgen deprivation therapy improved health-related quality of life ... Abiraterone acetate plus prednisone improves health-related quality of life in metastatic prostate cancer. ... Patients assigned abiraterone acetate and prednisone reported significant delays in time to pain and fatigue intensity and ... Efficacy results presented at this years ASCO Annual Meeting showed the addition of abiraterone acetate and prednisone to ...
... see colourful images of Abiraterone Acetate and explore interactive 3D molecules of Abiraterone Acetate ... Find out about the science and chemistry of Abiraterone Acetate (Zytiga, Abiratas, Abretone, Abirapro), ... click on the picture of Abiraterone Acetate above to interact with the 3D model of the. Abiraterone Acetate structure (this ... Abiraterone, the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase ( ...
Abiraterone acetate is the oral prodrug of abiraterone, a specific CYP17 inhibitor that blocks androgen biosynthesis within the ... Abiraterone acetate 1000 mg/day, combined with prednisone 5 mg PO twice daily, is indicated for the treatment of metastatic ... Abiraterone acetate is the oral prodrug of abiraterone, a specific CYP17 inhibitor that blocks androgen biosynthesis within the ... Abiraterone acetate and prednisone in chemotherapy-naïve prostate cancer patients: rationale, evidence and clinical utility. ...
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for ... A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for ... The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate and prednisone ... AA is a pro-drug of abiraterone and selectively inhibits the enzyme 17-hydroxylase/C17,20-lyase (CYP17), which is found in the ...
Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer (PROfound Study) ... The purpose of this study is to evaluate the efficacy and safety of olaparib versus enzalutamide or abiraterone acetate in ... Study of Olaparib (Lynparza ) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate ... Approximately 340 subjects will be randomized 2:1 (olaparib : investigator choice of enzalutamide or abiraterone acetate) into ...
I. To assess the impact of abiraterone acetate (abiraterone) and docetaxel on total quality of life between screening and month ... abiraterone acetate, prednisone) Participants receive androgen deprivation therapy (ADT) per standard of care, abiraterone ... Docetaxel or Abiraterone Acetate With ADT in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer (ACADEMIC). ... Drug: Abiraterone Acetate Drug: Antiandrogen Therapy Drug: Docetaxel Drug: Prednisone Other: Quality-of-Life Assessment Other: ...
  • I. To compare the pharmacodynamic effect of reduced dose (250mg daily) abiraterone acetate in the prandial state (250mg-Fed) to the full, standard 1000mg daily dose in the fasting state (1000mg-Fasting) as assessed by change in serum prostate-specific antigen (PSA). (knowcancer.com)
  • Although one patient with recurrent ovarian cancer achieved complete response, the first trial of abiraterone conducted in ovarian cancer was halted early due to low response, according to results from the CORAL phase 2 trial presented at the European Society of Medical Oncology Congress. (targetedonc.com)
  • This is the first trial of abiraterone in ovarian cancer," Banerjee said. (targetedonc.com)
  • The safety profiles for YONSA and OAA were similar and consistent with previously reported adverse events for abiraterone acetate. (medicalresearch.com)
  • Pharmaceutical compositions, including unit dosage forms, comprising fine particle abiraterone acetate with or without an antioxidant and or a sequestering agent as well as methods for producing and using such compositions are described. (patentsencyclopedia.com)
  • 7,10 The FDA approval of the fine-particle abiraterone acetate formu-lation was based on the STAAR clinical trial, which demonstrated the drug's therapeutic equivalence to the original abiraterone acetate formulation in patients with metastatic CRPC. (oncpracticemanagement.com)
  • Abiraterone acetate works by inhibiting specific "enzymes" in your adrenal glands that are responsible for making androgens. (medinglobal.com)
  • Abiraterone acetate is used on top of ADT to try to block the production of androgens in places other than the testicles, such as the adrenal glands or the tumor tissue, in order to inhibit tumor growth . (informedhealth.org)
  • If you miss a dose of abiraterone acetate, take your next dose at the normal scheduled time. (upmc.com)
  • The present disclosure relates to methods for producing particles of abiraterone acetate using dry milling processes as well as compositions comprising abiraterone acetate, medicaments produced using abiraterone acetate and to methods of treatment using a therapeutically effective amount of abiraterone acetate administered by way of said medicaments. (patentsencyclopedia.com)
  • The amount of abiraterone acetate you receive depends on many factors. (medinglobal.com)
  • • Xbira (Abiraterone Acetate ) is currently not indicated for use in women. (applepharma.us)
  • However, if Xbira (Abiraterone Acetate ) is given to a woman, getting pregnant should be avoided and the woman should not breast feed. (applepharma.us)
  • Store: Store Xbira (Abiraterone Acetate ) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. (applepharma.us)
  • Keep Xbira (Abiraterone Acetate ) out of the reach of children and away from pets. (applepharma.us)
  • This page contains brief information about abiraterone acetate and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials. (cancer.gov)
  • Find Clinical Trials for Abiraterone Acetate - Check for trials from NCI's list of cancer clinical trials now accepting patients. (cancer.gov)
  • The clinical trials on this list are studying Abiraterone Acetate. (cancer.gov)
  • In this article Carmel J. Pezaro, Deborah Mukherji and Johann S. De Bono review the preclinical discovery and clinical development of abiraterone acetate and outline the strategy of parallel translational research. (drugdiscoverytoday.com)
  • We demonstrate that the combination of these agents did not appear to alter immune parameters known to correlate with the clinical benefit observed with sipuleucel-T. Prednisone, which is coadministered with abiraterone, did not appear to impair the manufacture of sipuleucel-T or blunt the peripheral immune responses generated from treatment. (aacrjournals.org)
  • The concern was that "abiraterone acetate is given with prednisone, which may be immunosuppressive," noted lead author Eric J. Small, MD, Chief of the Department of Medicine in the Division of Hematology/Oncology and Associate Director of Clinical Sciences at the UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, and colleagues. (cancertherapyadvisor.com)
  • As a clinician, I believe the efficacy and safety profile of abiraterone acetate, as well as its oral, once-daily formulation, will help address the important need for additional therapeutic choices for men living with this serious disease. (btgplc.com)
  • Efficacy results presented at this year's ASCO Annual Meeting showed the addition of abiraterone acetate and prednisone to androgen deprivation therapy led to a 38% reduced risk for death. (healio.com)
  • Instrucción 14/2017 de la Secretaría Autonómica de Salud Pública y del Sistema Sanitario Público de declaración como MAISE de abiraterona, enzalutamica, cabazitaxel y Dicloruro de Radio 223 en cáncer de ulticen metástasico resistente a castración. (springer.com)