Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
Tumors or cancer of the COLON.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Hydrazines substituted with two methyl groups in any position.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
A subcategory of mucins that contain SIALIC ACID.
Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
A benign epithelial tumor with a glandular organization.
A plant genus of the family ZINGIBERACEAE, order Zingiberales, subclass Zingiberidae. Elettaria cardamomum (L.) Maton is the source of Cardamom used in SPICES.
The period of history from 1451 through 1600 of the common era.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.
The goosefoot plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. It includes beets and chard (BETA VULGARIS), as well as SPINACH, and salt tolerant plants.
Tumors or cancer of the INTESTINES.
A plant genus of the family ARACEAE. Members contain konjac glucomannan (MANNANS) and SEROTONIN.
Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.
The combination of two or more different factors in the production of cancer.
A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
A plant genus of the family HIPPOCASTANACEAE (or SAPINDACEAE by some) that contains antimicrobial protein 1 and escin. A. hippocastanum is used in folk medicine for treating chronic venous insufficiency.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
The use of chemical compounds to prevent the development of a specific disease.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Regular course of eating and drinking adopted by a person or animal.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.
The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
A malignant epithelial tumor with a glandular organization.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Use of plants or herbs to treat diseases or to alleviate pain.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
The consumption of edible substances.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
The growth of INTESTINAL POLYPS. Growth processes include neoplastic (ADENOMA and CARCINOMA) and non-neoplastic (hyperplastic, mucosal, inflammatory, and other polyps).
A mass of histologically normal tissue present in an abnormal location.
A method of data collection and a QUALITATIVE RESEARCH tool in which a small group of individuals are brought together and allowed to interact in a discussion of their opinions about topics, issues, or questions.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A rod-shaped, gram-positive, non-acid-fast, non-spore-forming, non-motile bacterium that is a genus of the family Bifidobacteriaceae, order Bifidobacteriales, class ACTINOBACTERIA. It inhabits the intestines and feces of humans as well as the human vagina.
Elements of limited time intervals, contributing to particular results or situations.
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.

Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats. (1/38)

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Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice. (2/38)

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Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. (3/38)

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Sodium butyrate does not decrease the evolution of precancerous lesions in rats. (4/38)

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Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum by boiled garlic powder. (5/38)

The scavenging capacity of reactive oxygen species, such as hydroxyl radicals, is reported not to decrease in boiled garlic (an odorless garlic preparation). We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum. Male F344 rats (5 weeks old) were fed a basal diet, or experimental diets containing 5% or 1% BGP for 5 weeks. One week later, all rats were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). At 10 weeks of age, all the rats were sacrificed, and the colorectum was evaluated for MDF and ACF. In rats given DMH and the 5% or 1% BGP diets (Groups 2 and 3), the numbers of MDF decreased significantly in a dose-dependent manner, compared with the DMH and basal diet value (Group 1) (p<0.01). The numbers of ACF in Group 2, but not Group 3, showed a non-significant tendency to decrease. Next, the effects of BGP on the formation of DMH-induced O6-methylguanine (O6-MeG) DNA adducts in rats were studied. Male F344 rats (5 weeks old) were fed the basal diet, or 10% BGP diet for 5 weeks. All rats were injected i.p. once with 40 mg/kg DMH at the end of week 5. The animals were sacrificed 6 hours after DMH injection to analyze the O6-MeG DNA adducts in the colorectal mucosa. Dietary administration of BGP significantly inhibited the O6-MeG DNA adduct levels in the colorectal mucosa, compared with the controls (p<0.01). These results suggested that BGP may exert chemopreventive effects against colon carcinogenesis at least in the initiation stage.  (+info)

Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention. (6/38)

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Histomorphology of aberrant crypt foci in colorectal carcinoma. (7/38)

Colorectal carcinogenesis is a complex multistep process that includes changes in histomorphological appearance of the colonic mucosa and changes at molecular level. Aberrant crypt foci (ACF) was first described by Bird in 1987 on examination of methylene-blue-stained colonic mucosa of azoxymethane-treated mice under light microscopy. Since then ACF was considered as the earliest preneoplastic change that can be seen in the colonic mucosa. The aim of this study was to look at the histomorphology and distribution of ACF in colorectal carcinoma. 50 formalin-fixed archival colectomy specimens for colorectal carcinoma were examined under light microscopy after staining with 0.2% methylene blue. ACF was identified by larger and darker crypts with thickened epithelium, and often elevated from adjacent normal mucosa. ACF was found in 41 of 50 colectomy specimens examined. There were 328 ACF consisting of 36 (11.0%) ACF without hyperplasia or dysplasia, 263 (80.2%) ACF with hyperplasia and 29 (8.8%) ACF with dysplasia. Of these 29 ACF with dysplasia, 25 showed low grade dysplasia and four high grade dysplasia. The density of ACF was higher in the left colon, those older than 65 years of age and among males but these findings were statistically not significant. The crypt multiplicity of hyperplastic ACF (30.149, SD 28.395) was larger than dysplastic ACF (20.613, SD 40.128). The spectrum of histological changes observed probably represent the evolution of ACF in colorectal carcinogenesis.  (+info)

Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps. (8/38)

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The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide. Therefore, new preventive strategies are needed to lower the burden of this disease. Previous studies reported that aspirin could suppress the development of sporadic colorectal adenoma. In addition, metformin is a biguanide derivative that is long widely used for the treatment of diabetes mellitus and has recently been suggested to have a suppressive effect on carcinogenesis and cancer cell growth. Both drugs exhibit a chemopreventive effect, but their efficacy is limited. Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate biomarker of CRC. Thus, we designed a prospective trial as a preliminary study prior to a CRC chemoprevention trial to evaluate the chemopreventive effect of aspirin combined with metformin on
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
Aberrant crypt foci can be identified in the colons of rodents treated 3 wk earlier with azoxymethane, a known colon carcinogen. These crypts can easily be visualized in the unsectioned methylene blue-stained colons under light microscopy, where they are distinguished by their increased size, more prominent epithelial cells, and pericryptal space. They occur as single aberrant crypts or as two, three, or four aberrant crypts in a cluster. We compared the reported ability of carcinogens associated with the human diet to induce colon cancer with the measured rate of induction of aberrant crypts in female CF1 mice and Sprague-Dawley rats. The carcinogens used were 1,2-dimethylhydrazine, methyl nitrosourea, N-nitrosodimethylamine, benzo(a)pyrene, aflatoxin B1, 2-amino-6-methyl-dipyrido[1,2-α:3′,2′-d]imidazole, 2-amino-3-methylimidazo[4,5-P]quinoline, 2-amino-3,4-dimethylimidazo[4,5-P]quinoline, and 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Graded doses of these compounds were given to the ...
Rice stem cell serum made from the best of Thai rice varieties is rich in antioxidants and essential amino acids that stimulate the growth of skin cells and slow the aging process.
The precise and systematic digestion and subsequent absorption of nutrients in food is vitally important for the life of all metazoans. The intestine is the organ primarily responsible for absorbing, processing, transporting, and excreting the vast variety of nutrients found in an organisms diet, and the tissue is maintained throughout its length by multipotent intestinal stem cells. Although previous work identified regions of preferential copper and iron absorption, only recent work is revealing the degree to which regions of the tissue can be specialized. The work presented in this thesis categorizes the extent of physiological, morphological, organizational and molecular heterogeneity along the intestinal anterior-posterior axis. This work is also the first to test stem cells of specific intestinal regions for their tumorigenic capacity and their ability to generate progeny of neighboring regions. I analyzed the properties of intestinal cells along the anterior-posterior axis and found that ...
Consuming higher amounts of calcium may lower the likelihood of precancerous colon and rectal lesions in people who are at increased risk due to variations in t
CHICAGO-Flat, non-polypoid colorectal neoplasms (NP-CRNs), which may be difficult to detect, appear to be relatively common and may have a greater association with cancer compared with the more routinely diagnosed type of colorectal polyps, according to a study in the March 5 issue of JAMA.
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
Why was purple rice forbidden? Forbidden rice earned its name because it was once reserved for the Chinese emperor to ensure his health and longevity, and
Principles of Cell and Molecular Biology Study Area IV. Prereq.: BMS 102 or BIO 121; or permission of department chair. Introduction to the major principles of cell biology including cell compartmentalization; flow of genetic information; protein structure, synthesis, and trafficking; signal transduction; and molecular responses resulting in changes in cell activity, cell division, or apoptosis. Three hours of lecture and one, three-hour laboratory per week ...
A total of 73 CRC patients who underwent MICR met the inclusion criteria (34 males /39 female, mean ages 66.3± 12.8 years; 28% rectal and 62% colon lesions). The mean incision length was 7.8 ± 3.6cm and mean length of stay was 6.8± 4.4 days. The final cancer staging breakdown was; Stage I, 27%, Stage II, 33%, stage III, 36% and stage IV, 4%. The mean PreOp MMP3 level was 14.9±7.8 ng/ml (n=73). Significantly elevated mean plasma levels were noted on POD1 (21.4±14.7ng/ml, n= 73, p=, 0.0001), POD3 (37.9±21.5 ng/ml, n= 72, p=, 0.0001), POD7-13 (22.0±13.0 ng/ml, n=56, p=, 0.0001), POD14-20 (21.9±10.3 ng/ml, n=20, p=0.003) and on POD 21-27 (21.9±11.43 ng/ml, n= 20, p=0.002) when compared to PreOp levels. Plasma levels returned to the PreOp baseline at the POD 28-41 time point (n=16, p=0.07).. Conclusion ...
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TY - JOUR. T1 - Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet. AU - Chihara, Takeshi. AU - Shimpo, Kan. AU - Kaneko, Takaaki. AU - Beppu, Hidehiko. AU - Higashiguchi, Takashi. AU - Sonoda, Shigeru. AU - Tanaka, Miyuki. AU - Yamada, Muneo. AU - Abe, Fumiaki. PY - 2015. Y1 - 2015. N2 - Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt ...
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
Ingredient Treasury For Gluten-Free BakingFlaxseed Meal: Known for being high in Omega 3 Fatty Acids and fiber, flaxseed meal is a favorable Can you use just
Colorectal cancer is one of the leading causes of cancer death, both in men and women. This study investigatedthe effects of Amorphophallus campanulatus tuber methanolic extract (ACME) on aberrant crypt foci (ACF)formation, colonic cell proliferation, lipid peroxidative damage and the antioxidant status in a long term preclinicalmodel of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in rats. Male Wistar rats were dividedinto six groups, viz., group I rats served as controls; group II rats treated as drug controls receiving 250 mg/kg body weight of ACME orally; group III rats received DMH (20 mg/kg body weight) subcutaneously once aweek for the first 15 weeks; groups IV, V and VI rats received ACME along with DMH during the initiation,post- initiation stages and the entire period of the study, respectively. All the rats were sacrificed at the end of 30weeks and the intestinal and colonic tissues from different groups were subjected to biochemical and histologicalstudies. Administration of DMH
Processed meat intake is associated with colorectal cancer risk, but no experimental study supports the epidemiologic evidence. To study the effect of meat processing on carcinogenesis promotion, we first did a 14-day study with 16 models of cured meat. Studied factors, in a 2 × 2 × 2 × 2 design, were muscle color (a proxy for heme level), processing temperature, added nitrite, and packaging. Fischer 344 rats were fed these 16 diets, and we evaluated fecal and urinary fat oxidation and cytotoxicity, three biomarkers of heme-induced carcinogenesis promotion. A principal component analysis allowed for selection of four cured meats for inclusion into a promotion study. These selected diets were given for 100 days to rats pretreated with 1,2-dimethylhydrazine. Colons were scored for preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF). Cured meat diets significantly increased the number of ACF/colon compared with a no-meat control diet (P = 0.002). Only the cooked ...
Effects Of Ground Flaxseed In Swine Diets On Pig Performance ...(CO) diet or a 15% flaxseed (FS) diet fed for 7, 14, 21, or 28 d prior to slaughter. Flaxseed
The nutritional value of flaxseed meal (FSM), a by-product of the flax crushing industry, has not been evaluated properly for use within swine rations. A series of experiments were conducted to determine the nutritional profile of this novel feed ingredient for pigs.The analysis of FSM revealed that it contains, on a dry matter (DM) basis, 133 g/kg ether extract (EE), 345 g/kg crude protein (CP), 60 g/kg ash, 164 g/kg ADF, 250 g/kg NDF, 102 g/kg crude fibre, 14 g/kg starch and 9 g/kg phosphorus. The gross energy (GE) content of the meal was 5.2 Mcal/kg DM. The ether extract fraction was characterized by, as a percent of total fat, 46.6% á-linolenic acid, an omega-3 fatty acid. Palmitic, stearic, oleic and linoleic acids accounted for 9.5, 4.8, 20.7 and 18.4% of the total fat content respectively. The crude protein content was well balanced for all amino acids with the exception of lysine (4.1% of CP), the level of which falls below that of the requirements for growing pigs (5.3% of CP for pigs ...
Colorectal cancer (CRC) is a multistep process that involves adenoma-carcinoma sequence. CRC can be prevented by routine screening, which can detect precancerous lesions. The aim of this study is to clarify whether faecal occult blood test (i-FOBT), tumor M2 pyruvate kinase (t-M2-PK), and endocannabinoid system molecules (cannabinoid receptors type 1-CB1, type 2-CB2, and fatty acid amide hydrolase-FAAH) might represent better diagnostic tools, alone or in combination, for an early diagnosis of CRC. An immunochemical FOB test (i-FOBT) and quantitative ELISA stool test for t-M2-PK were performed in 127 consecutive patients during a 12 month period. Endocannabinoid system molecules and t-M2-PK expression were detected by immunostaining in healthy tissues and normal mucosa surrounding adenomatous and cancerous colon lesions. i-FOBT and t-M2-PK combination leads to a better diagnostic accuracy for pre-neoplastic and neoplastic colon lesions. T-M2-PK quantification in stool samples and in biopsy ...
Background and aims: The molecular mechanisms underlying the promotion of colorectal carcinogenesis by a high-fat diet (HFD) remain unclear. We investigated the role of the insulin-signal pathway and the c-Jun N-terminal kinase (JNK) pathway, which reportedly play crucial roles in insulin resistance, during colorectal carcinogenesis in the presence of hyperinsulinemia induced by a HFD.. Methods: Azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colonic epithelium were compared between mice fed a normal diet (ND) and mice fed a HFD. A western blot analysis was performed to elucidate the mechanism affecting colorectal carcinogenesis by a HFD.. Results: The number of aberrant crypt foci and the colonic epithelial cell proliferative activity were significantly higher in the HFD group than in the ND group. While the plasma insulin level was significantly higher in the HFD group than in the ND group, a western blot analysis revealed the inactivation of Akt, which is ...
Im looking for recipes for pumpkin bread/muffins/cookies/[whatever I can make with some canned pumpkin, Bisquick, raisins, cinnamon], and came across
Cell cycle and cancer. Using time-lapse microscopy, we showed that nuclear envelope (NE) formation is mediated by reshaping of the endoplasmic reticulum and not as previously thought by vesicle fusion. Our results answered a long-standing question in the field of nuclear biology and provided a new paradigm for membrane dynamics. In continuation of this work we recently discovered a remarkable phenomenon whereby the NE becomes transiently ruptured and repaired during interphase in various human cancer cells. Strikingly, NE rupturing was associated with loss of cell compartmentalization and a catastrophic chromosome rearrangement event called chromothripsis and thus might be a source of genomic instability.. Cell differentiation and development. Using Drosophila genetics in combination with imaging and DNA sequencing methods in mouse and human stem cells, we discovered that several NE proteins play an essential role in transcriptional activation of developmentally regulated genes. These findings ...
Original entry: Nefeli Georgoulia, APPHY 226, Spring 2009 ==Overview== Authors: L. Mahadevan & T.J. Mitchinson Source: Nature, Vol. 435, 895-896, (2005) Soft Matter key words: polymerization, strain, mechanical bending ==Abstract== This paper is a collaboration between microtubule guru T. Mitchison and biotheorist giant L. Mahadevan. The two join forces to explore past work and to offer novel interpretation to the ever-tantalizing question: How is the chemical energy from GTP hydrolysis harnessed to power growth and shrinkage of microtubules in dynamic instability? Microtubules are part of the cellular cytoskeleton and their structure is that of a hollow tube, formed by the the stacking of thirteen protofilaments. They form a dynamic network through the continuous polymerization and depolymerization of tubulin monomer. This dynamic behavior regulates cell compartmentalization, cellular cargo transportation and perhaps most notably the tearing apart of chromosomes during cell ...
The study shows that one of the ECM proteolytic enzymes, the matrix metalloproteinase MMP9, protects mice that are also deficient for the protease plasmin from developing lethal inflammatory mass lesions in the colon. The lethal lesions develop from microscopic colon lesions caused by the inability of mice lacking functional plasmin to break down fibrin. MMP9 is not expressed in healthy colon mucosa but is delivered to the microscopic lesions in the colons of plasmin-deficient mice by invading inflammatory cells. However, in contrast to the combined lethal effects of MMP9 and plasmin deficiency during colon tissue homeostasis, male mice deficient for both MMP9 and plasmin do not differ from plasmin single-deficient mice in terms of incisional skin wound healing, implying that, under certain circumstances, other proteases are able to substitute for MMP9. ...
Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv, Price of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv, Cost of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv accessory. See the Price, Image and Description of Maruti 800 car Mdf Car Frame Oval - Mdf 1D Shv.
MDF(Plain MDF) SNSWOOD Specification Dimension: 1220x2440, 1830x2750mmx2.5/3/5/6/8/9/12/15/16/18/22/25mm, 1830x3660mmx16, 18mm Surface: 180#Grid well sanded Formal...
The dose-response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF) and to reduce prostaglandin E2 (PGE2) levels. Starting at either 7 or 22 weeks of age, the rats received aspirin. All rats received two doses of AOM (15 mg/kg each on days 7 and 14) and were killed on day 36. The lowest concentrations of aspirin to prevent ACF or reduce PGE2 levels were 600 and 400 mg/kg, respectively. To evaluate the prevention of tumors, rats received either 0 or 400 mg/kg aspirin for a total of 39 weeks with AOM (30 mg/kg) administered 7 days after the start of treatment. Aspirin had no effect on the yield of colon tumors. In a second experiment, rats started to receive 0, 200, 600 or 1800 mg/kg aspirin or 1000 mg/kg α-difluoromethylornithine (DFMO) +/- aspirin. Eight and 15 days later, all the rats received 15 mg/kg AOM. Eleven weeks later, animals that were receiving the control ...
The benefits of flaxseed are great in number. For a start of there are lots of good nutrients in each little seed. These include a wide spectrum of vitamins and minerals and lots of really good Omega 3 fats. In fact they have so much Omega 3 that they rival fish as a source of these valuable fats. This is good news if you are a vegan! More good news for vegans is that you can make a very good egg substitute using the gel found in flaxseeds. This gel is also found in the ground meal. It is very easy to use flaxseed meal as an egg substitute. You should also use it if you have an egg allergy.. Another neat thing about flaxseeds is that they contain practically zero amounts of carbohydrate. This is because the stored energy of the seed is in the form of oil. As a result they are great when it comes to producing food to fit in with a low carb diet.. You can use flaxseed meal in the same way that you use flour. This means that it is great for baking. Exchanging part of the flour for flaxseed meal ...
The influence of bovine lactoferrin (bLf) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). In experiment I, 2% and 0.2% bLf, and Bifidobacterium longum (B. longum) as a positive control at 3% were given in the diet for 4 weeks, along with two s.c. 15 mg/kg …
PRIMARY OBJECTIVES:. I. To determine mean percentage change from baseline in prostaglandin E2 (PGE2) within ACF pre and post 30 days of curcumin administration at a specified dose.. SECONDARY OBJECTIVS:. I. To determine mean percentage change from baseline in 5-hydroxy-eicosatetraenoic acid (5-HETE) within ACF pre and post 30 days of curcumin administration at a specified dose.. II. To determine mean percentage change from baseline in PGE2 and 5-HETE within comparison normal mucosa pre and post 30 days of curcumin administration at a specified dose.. III. To quantify corresponding enzyme changes in the cyclooxygenases (COX-1, COX-2,) and lipoxygenase (5-LOX) protein abundance. Semi-quantitative changes in these proteins will be measured by western blotting and correlated with changes in prostaglandins and leukotrienes respectively.. IV. Document changes in total ACF number. V. Determine proliferation by Ki-67 IHC in rectal mucosa pre and post therapy and correlate with changes in ACF number and ...
Follow This cooking class at Lets Get Cookin in Westlake Village was great fun - presented by prolific cookbook author, Hugh Carpenter, we foodies were immersed in Thai recipes, always good eats. Hughs dry sense of humor kept us in
Background Tertiary lymphoid structures (TLS) are leukocytes aggregates forming in non-lymphoid tissues in response to chronic inflammation. Salivary glands (SG) of patients with Sjögrens syndrome (SS) develop TLS characterised by B/T cell compartmentalization, specialised vasculature (HEV), functional B cell activation and local differentiation of autoreactive plasma cells. Although TLS presence in SS SG associates with an aggressive disease progression, the mechanisms triggering their formation in SS are largely unknown. We recently developed a model of inducible TLS formation, breach of self-tolerance and salivary hypofunction upon delivery of a replication-deficient adenovirus-5 (AdV5) into C57BL/6 mice SG. In this model, 3 weeks after infection, we observed fully formed and functional TLS, breach of self-tolerance and loss of salivary function.. Here we characterised the presence, function and relevance in TLS formation of the myeloid compartment in the first month post-infection. ...
Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, individually and in combination, were tested on azoxymethane induced colon carcinogenesis in Sprague-Dawley rats. The effect was observed on aberrant crypt foci (ACF), the preneoplastic lesion. To investigate the mechanism of action of the agents used, cell proliferation and the level of apoptosis were determined and the expression of cyclooxygenase-2 (COX-2) protein was analyzed in the colon. Following treatment, significant inhibition of the level of cell proliferation (P|0.01 in garlic; P|0.001 in tomato and P|0.001 in combination treatment group with respect to the carcinogen control group), significant induction of apoptosis (P|0.01 in garlic treated; P|0.01 in tomato treated and P|0
Introduction: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We performed high-magnification chromoscopic colonoscopy to identify ACF in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACF in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACF were also assessed.. Results: The prevalence of ACF was 64%, 88% and 95%, and the mean number of ACF was 3.6, 6.2 and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. Older age and men had increased prevalence and number of ACF. When ...
The Indonesian government expects the next delivery of imported rice to arrive by the end of March and help address concerns of a shortage in the food supply, a minister said. Citing traders in multiple countries, it was reported on Wednesday that the State Logistics Agency (Bulog) placed an order of 820,000 tons of imported Thai rice, more than four times higher than the initial order of 170,000 to 200,000 tons. Sutarto Alimoeso, president director of Bulog, declined to confirm the amount. State Enterprises Minister Mustafa Abubakar said Bulog needed to import more rice to plug a hole in domestic supplies. The rice order is a carryover from last year. The next shipment must come before March, because in March we will a big harvest here and that could disturb supply, Sutarto said. Rice is the main staple food for Indonesia. Local farmers have supplied 130 tons of rice this month, Sutarto said, in addition to the supply in Bulogs warehouses. He declined to disclose the current level of stocks, ...
in Thailand represents a significant portion of the Thai economy and labor force.[1] In 2017, the value of all Thai rice traded was 174.5 billion baht, about 12.9% of all farm production.[2] Of the 40% of Thais who work in agriculture, 16 Get Price ...
This recipe was given to me by my friend Yulia she grew up in Tajikistan a small land locked mountainous country in Central Asia, it was governed by Russia at that time. She learnt this dish while there it would be made as a big communal dish and shared as a family. Heres a nice little article on the country from a group of travel bloggers who drove across Asia and their views A rallying cry. Its a tasty dish that can be made with vegetables, I did one loaded with veggies and a mixture of red and white Thai rice, beef or chicken, a great one pot meal ...
Full nutritional breakdown of the calories in Flaxseed Pizza Crust based on the calories and nutrition in each ingredient, including Natures Path Organic FlaxPlus Flaxseed meal, Olive Oil, Egg, fresh, whole, raw, Parmesan Cheese, grated, Baking Powder and the other ingredients in this recipe.
Full nutritional breakdown of the calories in flax bread based on the calories and nutrition in each ingredient, including Olive Oil, Egg, fresh, whole, raw, Bobs Red Mill Whole Ground Flaxseed Meal, 2 Tbsp., low carb baking mix, Baking Powder and the other ingredients in this recipe.
usr/bin/perl -w use Crypt::OpenPGP; use Crypt::OpenPGP::KeyRing; my($keyfile, $email) = @ARGV; my $ring = Crypt::OpenPGP::KeyRing-,new(Filename =, $keyfile); my $pgp = Crypt::OpenPGP-,new(PubRing =, $ring); my $kb = $ring-,find_keyblock_by_uid($email); my $alg = $kb-,preferred_sk_alg; my $crypt = $pgp-,encrypt( Data =, squeamish ossifrage, Recipients =, [ $email ], Armour =, 1, ($alg ? (Cipher =, $alg) : ()), # use default if no preference loc +ated ); print $crypt; exit 0; { package Crypt::OpenPGP::KeyBlock; sub preferred_sk_alg { my $self = shift; use Crypt::OpenPGP::Cipher; my $supported = Crypt::OpenPGP::Cipher-,supported; my @prefs; for my $sig (@{ $self-,get(Crypt::OpenPGP::Signature) }) { if ($sig-,is_primary) { unshift @prefs, @{ $sig-,preferred_sk_alg }; } else { push @prefs, @{ $sig-,preferred_sk_alg }; } } for (@prefs) { return $_ if $supported-,{$_}; } return; } } { package Crypt::OpenPGP::Signature; sub is_primary { my $self = shift; my $packet = $self-,find_subpacket(25); # ...
All sheet goods are not created equal, if your next project calls for these versatile materials, Bill Hylton has some suggestions on what to buy.
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.. Shimizu K, Das SK, Baba M, Matsuura Y, Kanazawa K.. Source. Department of Life Science, Graduate School of Science and Technology, Kobe University, Rokkodai, Nada-ku, Kobe 657-8501, Japan.. Abstract. Artepillin C, a prenylated phenylpropanoid found specifically in Brazilian propolis, has been shown to be a bioavailable antioxidant. In this study, artepillin C was tested for colon cancer-preventing activity using azoxymethane-challenged ddY mice. Oral doses of 80 and 160 mg/kg body weight of propolis or 10mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively. In liver of the mice, glutathione S-transferase and NADPH:quinone reductase activity increased with the doses of propolis or artepillin C, and an antioxidant-responsive element (ARE) was found to be activated for binding ...
Results A single bout of exercise increased the expression and secretion of SPARC in skeletal muscle in both mice and humans. In addition, in an azoxymethane-induced colon cancer mouse model, regular low-intensity exercise significantly reduced the formation of aberrant crypt foci in wild-type mice but not in SPARC-null mice. Furthermore, regular exercise enhanced apoptosis in colon mucosal cells and increased the cleaved forms of caspase-3 and caspase-8 in wild-type mice but not in SPARC-null mice. Culture experiments showed that SPARC secretion from myocytes was induced by cyclic stretch and inhibited proliferation with apoptotic effect of colon cancer cells.. ...
I love cooking for other people, especially folks who are going through a rough patch and need a little help with meals. One of my friends that Ive been cooking for over the past year is so sweet. Whenever she returns the empty containers from the food Ive made, she thoughtfully tucks in a thank you note, a favorite recipe, some spices from my favorite spice store, or ingredients that she thinks I will get better use out of than she can. One of the ingredients shes given me a few packs of is flaxseed meal (ground up flaxseed). Flaxseeds are a wonderful source of fiber and heart healthy omega-3 essential fatty acids.. Ive sprinkled whole flaxseeds on yogurt and used flaxseed meal as a substitute for eggs in recipes, but did you know it can also be used to substitute for oil in baked recipes?. ...
4975 Colon cancer is one of the major causes of cancer mortality in the United States of America. Early detection and prevention are the important alternative approaches to control colon cancer. Recently, substantial attention has been focused on identifying naturally occurring chemopreventive compounds capable of inhibiting early events involved in malignant transformation. Of late, laboratory studies have demonstrated that silibinin exhibits various biological activities and significantly inhibits tumorigenesis at various organ sites in several rodent models. The present study is an attempt to investigate the dose-dependent effect of dietary silibinin on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation in Fisher 344 male rats. In addition, we analyzed the effect of silibinin on cell proliferation and the induction of apoptosis by immunohistochemical staining during AOM-induced ACF formation. Five-week-old male F344 rats were randomly divided into 12 groups and fed AIN-76A control ...
Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We carried out high-magnification chromoscopic colonoscopy to identify ACFs in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACFs in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACFs were also assessed.. Results: The prevalence of ACF was 64%, 88%, and 95%, and the mean number of ACF was 3.6, 6.2, and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. When differences in the prevalence and number of ACFs among age- ...
There is no consensus on what defines a reference for the world rice price. A review on rice as a differentiated commodity shed two important insights. First, it confirms that few studies have considered segmentation of rice in their price analysis. Second, Thai 5% brokens has often been considered the world reference price for rice but no empirical exercise has been carried out to validate this. This study analyzes the extent of market integration in the international rice market by generating empirical evidence on the cointegration of different export prices. We start our analysis with the assumption that rice is not a homogeneous good. In this context, we establish clusters by rice quality and determine which export markets best represent the world rice price within and across clusters. The study uses 19 monthly average export rice price quotations from January 2000 to July 2012 extracted from the FAO Global Information and Early Warning System food price database and from the Thai Rice Exporters
Double Bear brands rice flour is produced from high quality and selected species of Thai rice. It is sorted fromthe best rice growing regions and carefully stored and managed in accordance with international standards. Modern production process together with the knowhow that we have accumulated for over 35 years result in the best quality rice flour which meets a wide range of customers needs.. ...
Preheat oven at 375. Mix 2 T of flaxseed meal and water, set aside 3-5 minutes. Cream butter and sugar. Add eggs. Stir flaxseed mix into butter mix and add vanilla. Beat until well blended. Sift: dry ingredients, except oats and choc chips. Add butter mix to dry ing. Stir in the oats and then the choc chips. Drop on parchmant paper on baking sheet. Bake 8-12 minutes ...
Flax seed is helpful for weight loss. Flax is grown for getting its seeds, which can be included in flaxseed meal that are pressed into the oil or produced into linen.
Now I have traded oats for flaxseed meal and chia. Have you tried chia cereal? I reviewed chia seeds last fall (that post is HERE) and I really have enjoyed having them in my diet BUT recently found what I like even better -- Milled Chia -- the texture is much more *cereal*-like and not so seedy to me. ...
Index: php-7.2.12/ext/standard/config.m4 =================================================================== --- php-7.2.12.orig/ext/standard/config.m4 2018-11-06 11:48:33.000000000 +0100 +++ php-7.2.12/ext/standard/config.m4 2018-11-09 16:35:10.505160977 +0100 @@ -242,7 +242,7 @@ int main() { dnl dnl If one of them is missing, use our own implementation, portable code is then possible dnl -if test $ac_cv_crypt_blowfish = no ,, test $ac_cv_crypt_des = no ,, test $ac_cv_crypt_ext_des = no ,, test $ac_cv_crypt_md5 = no ,, test $ac_cv_crypt_sha512 = no ,, test $ac_cv_crypt_sha256 = no ,, test x$php_crypt_r = x0; then +if test $ac_cv_crypt_blowfish = no ,, test $ac_cv_crypt_des = no ,, test $ac_cv_crypt_md5 = no ,, test $ac_cv_crypt_sha512 = no ,, test $ac_cv_crypt_sha256 = no ,, test x$ac_cv_lib_crypt_crypt_r = x0; then dnl dnl Check for __alignof__ support in the ...
Culture Crypt presents the complete and definitive episode guide for Orphan Black, including a summary, synopsis, recap, and review of every episode from Season Two. Orphan Black premiered on BBC America in March of 2013, and stars Tatiana Maslany.
Resveratrol glucoside from transgenic alfalfa prevents aberrant crypt foci in mice. Resveratroloside (3,5,4'-trihydroxystilbene ... "Resveratrol from Transgenic Alfalfa for Prevention of Aberrant Crypt Foci in Mice". Nutrition and Cancer. 62 (3): 351-361. doi: ...
Pretlow TP, Pretlow TG (November 2005). "Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer?". ...
"Aberrant crypt foci of the colon as precursors of adenoma and cancer". N Engl J Med. 339 (18): 1277-84. doi:10.1056/ ... 2-dimethylhydrazine produced significantly higher numbers of aberrant crypt foci (ACF) colon lesions than did the carcinogen ...
July 1992). "Promotion of aberrant crypt foci and cancer in rat colon by thermolyzed protein". J. Natl. Cancer Inst. 84 (13): ...
June 2005). "Metallothionein crypt-restricted immunopositivity indices (MTCRII) correlate with aberrant crypt foci (ACF) in ... crypt-restricted immunopositivity indices (MTCRII) monosomy 7 Mouse orthologue of ARX MRP4 Msi-1 Musashi Musashi-1 Mutant BCRP ...
"Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM". American Journal ... "Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts ...
... in drinking water enhance the growth of aberrant crypt foci in the mouse colon". Journal of Toxicology and Environmental Health ...
... is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. ... 2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary ...
... human gene Aberrant crypt foci, a preneoplastic lesion on the mucosa of colon or rectum Antecubital fossa, part of the ...
... on colonic aberrant crypt foci formation in rats". Cancer Lett 107 (1): 137-142. PMID 8913278. doi:10.1016/0304-3835(96)04354-6 ...
... on colonic aberrant crypt foci formation in rats.". Cancer Lett. 107 (1): 137-142. PMID 8913278. doi:10.1016/0304-3835(96)04354 ...
... on colonic aberrant crypt foci formation in rats.". Cancer Lett 107 (1): 137-142. ...
... (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...
Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y. Aberrant crypt foci of ... Aberrant crypt foci,ACF)的數量顯著增加[26]。異常腺窩病灶為大腸癌的
... on colonic aberrant crypt foci formation in rats. - Cancer Lett, 1996, kd 107, nr 1, lk 137-142. Resümee. Resümee. ...
Aberrant crypt foci. *Aphasiology. *Apoplexy. *Atypia. *Atypical small acinar proliferation. B. *Banff Classification ...
"Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis". Cancer Lett. 165 (1): 27 ...
... in drinking water enhance the growth of aberrant crypt foci in the mouse colon". 《Journal of Toxicology and Environmental ...
Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. DNA methyltransferase ... "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". ... crypt expansion and altered differentiation timing of ISCs, and proliferation and maintenance of MaSCs. GRCh38: Ensembl release ... to form a complex at replication foci". Nature Genetics. 25 (3): 269-77. doi:10.1038/77023. PMID 10888872. S2CID 26149386. Kim ...
Almost every crypt in all tissue samples from this patient showed high expression of KU86. However, the majority of crypts in ... Field defects associated with gastrointestinal tract cancers also commonly displayed reduced apoptosis competence, aberrant ... These initial molecular changes may subsequently progress to cytologically recognizable premalignant foci of dysplasia, and ... The crypts with reduced or absent expression of ERCC1 or PMS2 usually occurred in large patches of adjacent crypts. Both ERCC1 ...
Abnormal (aberrant) methylation occurs as a normal consequence of normal aging and the risk of colorectal cancer increases as a ... The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell. The most commonly ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ...
Aberrant DNA methylation patterns - hypermethylation and hypomethylation compared to normal tissue - have been associated with ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ... natural selection of a mutant or epigenetically altered cell among the stem cells at the base of one of the intestinal crypts ... Loss of that methylation can induce the aberrant expression of oncogenes, leading to cancer pathogenesis. Known mechanisms of ...
In 2009, two African American albinistic fashion models, Shaun Ross and Diandra Forrest, were the focus of an episode of the ... ISBN 978-0-7607-3979-2. "Tales From the Urban Crypt". New York Daily News Online. Archived from the original on 15 May 2008. ... aberrant even before his experimentation, he subsequently became completely deranged. Albino bias is also alleged in modern ... and his albinism is not the central focus of his character. (While his name, or lack thereof, seems to indicate otherwise, all ...
Studies of this issue have focused mainly at the gene mutation level, as copy number variation, LOH and specific chromosomal ... leading to the accumulation of aberrant cells. Most mammalian cells can replicate a limited number of times due to progressive ... predispose to clonal expansions that encompass large numbers of crypts in some conditions such as Barrett's esophagus. He also ... Many of the somatic evolutionary studies have traditionally been focused on clonal expansion, as recurrent types of changes can ...
ISBN 0-262-54057-6. Dufresne, Todd (2000). Tales From the Freudian Crypt: The Death Drive in Text and Context. Stanford, ... ISBN 0-333-48638-2. Genosko, Gary (2002). Félix Guattari: An Aberrant Introduction. London: Continuum. ISBN 0-8264-6034-8. ... who nevertheless found its approach to interpretation limited by its focus on the ideas of symbol and double meaning, Richard ...
The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell.[37][38][39] The most ... aberrant) methylation occurs as a normal consequence of normal aging and the risk of colorectal cancer increases as a person ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ...
Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between ... In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the ... Gout, Stéphanie; Huot, Jacques (2008). "Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer". Cancer ... "Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging". Nature. 507 (7492): 362-5. Bibcode: ...
However, some genetically normal iPSCs failed to produce all-iPSC mice because of aberrant epigenetic silencing of the ... Shifting the focus from internal reprogramming to external forcing". Ageing Research Reviews. 12 (1): 29-38. doi:10.1016/j.arr. ... from Intestinal Crypts". Cell Reports. 6 (6): 1046-1058. doi:10.1016/j.celrep.2014.02.013. PMC 4245054. PMID 24613355. Hendry, ...
Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...
CpG island methylation in aberrant crypt foci of the colorectum.. Chan AO1, Broaddus RR, Houlihan PS, Issa JP, Hamilton SR, ... Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island ...
Aberrant crypt foci (ACF) have been identified in the methylene-blue stained mucosa of the human colon. Some lines of evidence ... Histology of aberrant crypt foci in the human colon Histopathology. 1997 Apr;30(4):328-34. doi: 10.1046/j.1365-2559.1997.d01- ... Aberrant crypt foci (ACF) have been identified in the methylene-blue stained mucosa of the human colon. Some lines of evidence ... Finally, hyperplastic foci were significantly larger than foci of group A and C. Group B ACF were also more frequent in the ...
All 20 subjects had aberrant crypt foci at base line.. RESULTS: We identified 3155 aberrant crypt foci, 161 of which were ... correlations between the number of aberrant crypt foci, the presence of dysplastic foci, the size of the foci, and the number ... Aberrant crypt foci of the colon as precursors of adenoma and cancer.. Takayama T1, Katsuki S, Takahashi Y, Ohi M, Nojiri S, ... Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied mainly in ...
The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons ... Twenty-six aberrant crypt foci displayed dysplasia as evident by histologic analysis. In these instances we feel the term ... Identification and quantification of aberrant crypt foci and microadenomas in the human colon Hum Pathol. 1991 Mar;22(3):287-94 ... The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons ...
... the chemopreventive effect of annatto (Bixa orellana L.) ... dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat ... on the formation of aberrant crypt foci (ACF) induced by dimethylhydrazine (DMH) in rat colon. Further, we investigate, the ... Conversely, annatto was successful in inhibiting the number of crypts/colon (animal), but not in the incidence of DMH-induced ...
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we ... Keywords: aberrant crypt foci; biomarker; colon cancer; chemoprevention aberrant crypt foci; biomarker; colon cancer; ... Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer. Michael J. Wargovich * , Vondina R. Brown. ... Wargovich, M.J.; Brown, V.R.; Morris, J. Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer. Cancers ...
Significance and Applicability of Aberrant Crypt Foci in Clinical Practice , IntechOpen, Published on: 2014-03-12. Authors: ... Aberrant crypts can be observed as single altered crypt or as a cluster of altered crypts that form a focus termed ACF [8; 14; ... Dysplastic aberrant crypts of human colorectal mucosa accompanying FAP (left). The focus is composed of 4 crypts. The level of ... Figure 3. Dysplastic aberrant crypts of human colorectal mucosa accompanying FAP (left). The focus is composed of 4 crypts. The ...
Crypts are 2 - 3x larger and more dilated than normal crypts, may have a foci of dysplasia * ACF can be subclassified as ... Cite this page: Jain S. Aberrant crypt foci (ACF) in colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/ ... Endoscopy: aberrent cryptic foci are stained darker than normal crypts with Methylene blue using high magnification ...
... observed for foci with up to 4 crypts, but not for foci with 5 or more crypts. This may be explained by the fact that foci with ... Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats1 ... The emergence of aberrant crypt foci (ACF) is one of the most important outcome parameters in such models2. ... 5. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa, K, Miyake H, Niitsu Y. Aberrant crypt foci ...
Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in ... β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats," BioMed Research ...
Changes in Total Aberrant Crypt Foci (ACF) Number [ Time Frame: Baseline to 30 days ]. Changes in total aberrant crypt foci ( ... values found in rectal aberrant crypt foci (ACF) tissue. *Post-treatment in Prostaglandin E2 (PGE2) Within Aberrant Crypt Foci ... Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci). This study has ... Aberrant Crypt Foci. Substance-Related Disorders. Chemically-Induced Disorders. Mental Disorders. Precancerous Conditions. ...
Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid MAGNUSON B. A. ... Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon * * MORISHITA ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer BIRD R. P. ... Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats PEREIRA M. A. ...
Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm. Eiji Sakai, ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm ...
Somatic APC and K-ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark ... Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, ... ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark Penner, Kazy Hay, ... ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark Penner, Kazy Hay, ...
The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics ... The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics ... we found that HQT inhibits azoxymethane-induced aberrant crypt foci (ACF) formation in a preneoplastic colonic ACF rat model. ...
Aberrant crypt foci AgNORs Pronyl-lysine Cell proliferation Chemoprevention This is a preview of subscription content, log in ... Bird RP (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93:55-71PubMed ... Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon ... Agner AR, Bazo AP, Ribeiro LR, Salvadori DM (2005) DNA damage and aberrant crypt foci as putative biomarkers to evaluate the ...
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats Velmurugan ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ...
Phase IIA Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci). Trial Phase:. ... Phase IIA Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) ...
GOMIDES, Antônio Frederico de Freitas et al. Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon ... Palavras-chave : Defatted flaxseed; Aberrant crypt foci; P53 protein; Bifidobacterium spp. · resumo em Espanhol · texto em ... goal of this study was to investigate the preventive effects of defatted flaxseed meal on the appearance of aberrant crypt foci ... When we analyzed ACF with more than three crypts the group LIN and LINCA did not present ACF in the middle and distal segments ...
Then, the CEE was used to determine the effects on the progression of aberrant crypt foci (ACF), a preneoplastic lesion seen in ... Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa ... Rats fed with only the high dose of CEE had significantly decreased numbers of ACF per rat (45.56%) and crypt multiplicity (AC/ ... This finding could be concluded that purple rice extracts inhibited aberrant colonic epithelial cell progression via apoptosis ...
... of one crypt foci, 41% of two crypt foci, 18% of three crypt foci, and 21% of four or more crypt foci (Fig. 4A ). Rats fed β- ... Aberrant crypt multiplicity was determined as the number of crypts in each focus and categorized as containing up to four or ... A, normal crypt (10×), one crypt to four or more crypts (4×), and five crypts ACF (20×). B, effect of β-ionone on azoxymethane- ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71. ...
1 to 9 crypts; medium, 10 to 19 crypts; and large, 20 crypts or more per focus; ref. 22; Fig. 1). All ACF were recorded ... Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial. Kunihiro Hosono, Hiroki Endo, Hirokazu ... Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998;339:1277-84. ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71. ...
The combination of 1α, 25(OH)2 - Vitamin D3, calcium and acetylsalicyclic acid affects azoxymethane-induced aberrant crypt foci ... The combination of 1α, 25(OH)2 - Vitamin D3, calcium and acetylsalicyclic acid affects azoxymethane-induced aberrant crypt foci ... The combination of 1α, 25(OH)2 - Vitamin D3, calcium and acetylsalicyclic acid affects azoxymethane-induced aberrant crypt foci ... on development of aberrant crypt foci (ACF) and tumours in colon were examined in groups of 16 male F344 rats initiated with ...
"Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention" and "Aberrant crypt foci in the ... Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention. Cancer Prev Res 2008;1:4-8. ... Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control 2012;23:355-61. ... Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis 2007;28:769-76 ...
Herein, we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using ... Herein, we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using ...
Keywords: ACF, aberrant crypt foci; AOM, azoxymethane; DMH, 1,2-dimethylhydrazine; FAA, focal areas of atypism; H&E, ... Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen ... Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen ...
Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC ... Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients. *Marek Kowalczyk1. , ... Aberrant crypt foci (ACF) were first described by Bird in mice exposed to a mutagenic agent - azoxymethane in 1987 [1]. ... Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasm. Am J ...
Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with ... methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate ... Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with ... Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila). 2010;3(9):1077-83. ...
Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell ... Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell ... Aberrant Crypt Foci. Aberrant crypt foci (ACF) were induced using AOM and DSS. Six-week-old female Wt and Prom1-/- mice (N = 5 ... Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate ...
  • Aberrant crypt foci (ACF) have been identified in the methylene-blue stained mucosa of the human colon. (nih.gov)
  • Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied mainly in surgical specimens from patients who already had colon cancer. (nih.gov)
  • Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. (aacrjournals.org)
  • ACF are tiny lesions that develop in the earliest stage of colorectal carcinogenesis and consist of large, thick crypts identified by dense methylene blue staining ( 18 - 21 ). (aacrjournals.org)
  • Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM). (oup.com)
  • Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). (biomedcentral.com)
  • Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate biomarker of CRC. (biomedcentral.com)
  • Aberrant crypt foci (ACF) are microscopic lesions of the colonic mucosa suspected of being preneoplastic, and their investigation has been advocated to evaluate the cause-effect relationship between putative risk factors and CRC. (aacrjournals.org)
  • Aberrant crypt foci (ACF) are grossly unidentifiable lesions of the colon and visible only with low- power microscopic examinations after methylene blue stain . (bvsalud.org)
  • natalensis Berger (designated as 'ALOE') on azoxymethane (AOM)-induced aberrant crypt foci (ACF), putative preneoplastic lesions, in the rat colorectum. (fujita-hu.ac.jp)
  • Aims of the study: To investigate whether tomatoes and onions,with low or high quercetin-glycoside content, could reduce azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF), preneoplastic lesions in the colon of rats. (wur.nl)
  • aberrant crypt foci (ACF) are colon preneoplastic lesions that can be used as a tool to study preventive processes for colorectal cancer (CRC). (isciii.es)
  • We therefore investigated whether a 1-year administration of different l -carnitine concentrations (0, 1, 2 and 5 g/l) via drinking water leads to an increased incidence of preneoplastic lesions (so-called aberrant crypt foci ) in the colon of Fischer 344 rats as well as to the appearance of atherosclerotic lesions in the aorta of these animals. (springer.com)
  • In this paper, we investigated the involvement of endocannabinoids on the formation of aberrant crypt foci (ACF, earliest preneoplastic lesions) in the colon mouse in vivo. (420magazine.com)
  • Development of colon cancer is a multistep process involving a series of pathological alterations ranging from discrete microscopic mucosal lesions, like aberrant crypt foci (ACF), to malignant tumors [2]. (420magazine.com)
  • ACF are early focal lesions of the colonic mucosa composed of one to several enlarged crypts, which are specifically induced by colon carcinogens [3]. (420magazine.com)
  • Our aim was to study the chemopreventive efficacy of pronyl-lysine, a key antioxidant present in bread crust by evaluating, the total number of aberrant crypt foci (ACF), their distributions, dysplastic ACF, colonic tumor incidence and the expression of cell proliferation biomarker such as the argyrophilic nucleolar organizing region-associated proteins (AgNORs) in 1,2-dimethylhydrazine (DMH) induced colon cancer in rats. (springer.com)
  • Deeptha K, Kamaleeswari M, Sengottuvelan M, Nalini N (2006) Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats. (springer.com)
  • The present study is an attempt to investigate the dose-dependent effect of dietary silibinin on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation in Fisher 344 male rats. (aacrjournals.org)
  • Then, the CEE was used to determine the effects on the progression of aberrant crypt foci (ACF), a preneoplastic lesion seen in colon carcinogenesis in rats. (biomedsearch.com)
  • Rats fed with only the high dose of CEE had significantly decreased numbers of ACF per rat (45.56%) and crypt multiplicity (AC/focus) (16.67%) compared to rats that received DMH alone. (biomedsearch.com)
  • Effects of 1alpha,25(OH)(2)-vitamin D(3) and acetylsalicylic acid at various dietary levels of calcium (CaCO(3)) on development of aberrant crypt foci (ACF) and tumours in colon were examined in groups of 16 male F344 rats initiated with azoxymethane and observed for 16 weeks. (dtu.dk)
  • Colons of 10 rats from each dietary group were analyzed for aberrant crypt foci (ACF), which are preneoplastic markers. (uoi.gr)
  • Colonic mucosal proliferation, aberrant crypt foci (ACF) induction, and fecal bile acids, parameters connected to the risk of colon cancer development, were studied in female F344 rats treated with starch or sucrose boluses or with a sucrose diet. (naver.com)
  • In additional experiments, colon cell proliferation (MF/crypt) was higher in rats given boluses of sucrose three times per week for 40 days after AOM (20 mg/kg) [5.9 ± 0.7 (SE)] than in rats given starch boluses (2.96 ± 0.4) or fed sucrose continuously (3.6 ± 0.5). (naver.com)
  • This study investigatedthe effects of Amorphophallus campanulatus tuber methanolic extract (ACME) on aberrant crypt foci (ACF)formation, colonic cell proliferation, lipid peroxidative damage and the antioxidant status in a long term preclinicalmodel of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in rats. (waocp.org)
  • In this study, the chemopreventive potential of Cranberry was analyzed in reducing the Aberrant Crypt Foci (ACF) induced by Azoxymethane (AOM) in Fisher 344 male rats. (cranberryinstitute.org)
  • Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation has been described as an important molecular pathway. (nih.gov)
  • DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. (greenmedinfo.com)
  • Sengottuvelan M, Viswanathan P, Nalini N (2006) Chemopreventive effect of trans-resveratrol-a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis. (springer.com)
  • We tested the in vivo chemopreventive efficacy in rat colon carcinogenesis model using aberrant crypt foci (ACF) as endpoint marker. (aacrjournals.org)
  • We also examine the chemopreventive efficacy of β-ionone on azoxymethane-induced rat colon carcinogenesis model using colonic aberrant crypt foci (ACF) as endpoint biomarker. (aacrjournals.org)
  • Objective To study the effect of macrophage migration inhibitory factor(MIF) antibody on the rat colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine ( DMH ), carcinoma number and expression of MIF in rat colonic carcinogenesis . (bvsalud.org)
  • Blume Tuber Against Aberrant Crypt Foci and Cell Proliferation in 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis', Asian Pacific Journal of Cancer Prevention , 14(9), pp. 5331-5339. (waocp.org)
  • The aim of this study was to investigate the effects of the commercial disperse dye product containing the CI Disperse Blue 291 on rat colon carcinogenesis, evaluated by the single cell gel assay (comet assay) and by aberrant crypt foci development. (usp.br)
  • Inoculation with La reduced the severity of colonic carcinogenesis caused by CT-26 cells, such as level of colonic involvement and structural abnormality of epithelial/crypt damage. (cambridge.org)
  • Moreover, analysis of preneoplastic aberrant crypt foci from high-risk patients suggests that acquisition of the high-COX-2/low-cPLA 2 phenotype may arise at an early stage of colon carcinogenesis. (aacrjournals.org)
  • Cell proliferation was higher in animals treated with a single sucrose bolus than in those given a starch bolus (15 g/kg body wt), with 4.3 ± 0.64 and 2.17 ± 0.57 (SE) mitotic figures (MF) per crypt in the sucrose and starch bolus groups, respectively (p (naver.com)
  • The excised colons were evaluated for aberrant crypt foci (ACF) formation, cell proliferation (PCNA assay), apoptosis (TUNEL assay), and iNOS and COX-2 expression. (tamu.edu)
  • Generalized disruption of Wnt signaling in the intestine resulted in widespread loss of crypts with the absence of cell proliferation in the small intestine, indicating an essential role for this pathway in the maintenance of intestinal stem cells and their dividing descendents. (pnas.org)
  • This reduction in aberrant crypt foci (ACF) was accompanied by suppression of cell proliferation (mean Brdu LI in carcinogen control=13.91+/-3.31, and 0.5% cardamom=2.723+/-0.830) and induction of apoptosis (mean AI in carcinogen control=1.547+/-0.42 and 0.5% cardamom=6.61+/-0.55). (sigmaaldrich.com)
  • 0.001) correlations between the number of aberrant crypt foci, the presence of dysplastic foci, the size of the foci, and the number of adenomas. (nih.gov)
  • Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell compartment and in early intestinal adenomas. (frontiersin.org)
  • Aberrant crypt foci (ACF) are putative precursors of colorectal adenomas and have been postulated as a potential biomarker for colorectal cancer. (wustl.edu)
  • To determine the effect of the study drugs (aspirin [acetylsalicylic acid] + DFMO) and placebo with respect to proliferation (Ki67 labeling index), apoptosis (caspase-3 expression assay), and drug effect markers (COX-1, -2, polyamines, PGE2) from adenomas, aberrant crypt focus (ACF) and normal-appearing mucosa using pre- and 12-month post-intervention tissue biopsy samples. (clinicaltrials.gov)
  • I. To explore the effects of the study agents on a focused panel of tissue biomarkers in pre- and post-intervention biopsy samples from recurrent adenomas, rectal ACF, and adjacent normal-appearing mucosa among subjects enrolled in the phase II clinical trial. (clinicaltrials.gov)
  • 15 However, while microsatellite instability (MSI) may be established at an early stage in adenoma formation, including microscopic aberrant crypt foci, 2 16 17 mutated genes have not been detected at high frequency in adenomas showing MSI. (bmj.com)
  • The adenoma to carcinoma sequence is characterized by recognizable histologic changes that start with dysplastic aberrant crypt foci and benign tubular adenomas. (aacrjournals.org)
  • The aberrant methylation of certain tumor suppressor genes, such as CDKN2A , has been reported in colonic adenomas and aberrant crypt foci (7-9) . (aacrjournals.org)
  • The Aspirin/Folate Polyp Prevention Study reported that folic acid supplementation at 1 mg/day for 6-10 years significantly increased the risk of recurrence of advanced and multiple colorectal adenomas [15] and of prostate cancer [16] in predisposed subjects with prior colorectal adenomas who likely harboured preneoplastic foci. (plos.org)
  • Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. (mdpi.com)
  • This phase II trial is studying how well curcumin works in preventing colon cancer in smokers with aberrant crypt foci. (clinicaltrials.gov)
  • Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa L. var. (biomedsearch.com)
  • The density of aberrant crypt foci (ACF), the earliest identifiable mucosal abnormality, may serve as a surrogate marker for colon cancer risk, but has rarely been studied in the proximal colon. (aacrjournals.org)
  • Herein, we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using azoxymethane (AOM)-induced colon cancer mice model. (oup.com)
  • Thermolyzed casein in particular has shown to cause the growth of aberrant crypt foci (ACF tumors) and colon cancer. (mercola.com)
  • Aberrant crypt foci of the colon as precursors of adenoma and cancer. (nih.gov)
  • Using magnifying endoscopy, we studied the prevalence, number, size, and dysplastic features of aberrant crypt foci and their distribution according to age in 171 normal subjects, 131 patients with adenoma, and 48 patients with colorectal cancer. (nih.gov)
  • We also prospectively examined the prevalence of aberrant crypt foci in 11 subjects (4 normal subjects, 6 with adenoma, and 1 with cancer) before and after the administration of 100 mg of sulindac three times a day for 8 to 12 months and compared the results with those in 9 untreated subjects (4 normal subjects and 5 with adenoma). (nih.gov)
  • Aberrant crypt foci, particularly those that are large and have dysplastic features, may be precursors of adenoma and cancer. (nih.gov)
  • Hyperplastic aberrant crypts of human (left) colorectal mucosa accompanying resected sporadic colorectal adenoma. (intechopen.com)
  • Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis (2001) Takayama Tetsuji et al. (naver.com)
  • An aberrant crypt focus obtains a KRAS mutation and progresses to an early adenoma. (brainscape.com)
  • Determine the aberrant crypt foci (ACF) and adenoma burden in the entire colorectum of these patients. (clinicaltrials.gov)
  • Aberrant crypt foci (ACF) are morphologically identifiable mucosal abnormalities, a subset of which may be precancerous and contribute to a "field defect" within the mucosa ( 5 ). (aacrjournals.org)
  • The intestinal tract is lined by mucosa, which is primarily composed of villi or the intercrypt table and epithelial-lined crypts at the mucosal base ( 1 - 4 ). (frontiersin.org)
  • The mucosal epithelial cells arise from intestinal stem cells located in the crypt ( 5 ). (frontiersin.org)
  • The histopathological images of the IMF-8 treated colon showed no signs of mucosal crypt abscess. (elsevier.com)
  • Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. (aacrjournals.org)
  • Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. (wikipedia.org)
  • The goal of this study was to investigate the preventive effects of defatted flaxseed meal on the appearance of aberrant crypt foci (ACF) in mice treated with 1,2-dimethylhydrazine (DMH). (isciii.es)
  • Aberrant crypt foci (ACF) were first described by Bird in mice exposed to a mutagenic agent - azoxymethane in 1987 [ 1 ]. (biomedcentral.com)
  • In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. (fujita-hu.ac.jp)
  • Journal Article] Lack of enhancing effects of degraded λ-carrageenan on the development of β-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane. (nii.ac.jp)
  • The epithelial cells of the hyperplastic crypts are higher and composed of one layer. (intechopen.com)
  • The epithelial cells covering the aberrant crypts are classified as mild dysplasia. (intechopen.com)
  • Results indicate that feeding of lactulose and B. longum singly and in combination reduces the number of ACF (P = 0.0001) and the total number of aberrant crypts significantly (P = 0.0005). (uoi.gr)
  • When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. (wikipedia.org)
  • There was a close correlation between the number of crypts per ACF in each specimen as scored by methylene-blue and histologic examination. (nih.gov)
  • Fingerprint Dive into the research topics of 'Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. (fujita-hu.ac.jp)
  • Carcinoembryonic antigen in human colonic aberrant crypt foci (1994) Pretlow Theresa P et al. (naver.com)
  • In the present study, we evaluate the activity of annatto (Bixa orellana L.), a natural food colorant rich in carotenoid, on the formation of aberrant crypt foci (ACF) induced by dimethylhydrazine (DMH) in rat colon. (greenmedinfo.com)
  • Here, we found that HQT inhibits azoxymethane-induced aberrant crypt foci (ACF) formation in a preneoplastic colonic ACF rat model. (rsc.org)
  • 0.001) reduces the total number and crypt multiplicity of AOM-induced ACF formation in a dose-dependent manner. (aacrjournals.org)
  • Furthermore, we showed that metformin suppressed the azoxymethane-induced formation of colorectal aberrant crypt foci (ACF) by activating AMPK ( 17 ). (aacrjournals.org)
  • Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon. (propolisscience.org)
  • Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. (fujita-hu.ac.jp)
  • 7 crypts) decreased with increasing dose of FaOH and FaDOH and that this inhibitory effect on early neoplastic formation of ACF was dose-dependent, which was also the case for the total number of macroscopic neoplasms. (aau.dk)
  • Notably, N-arachidonoylserotonin completely prevented the formation of ACF with four or more crypts, which have been show to be best correlated with final tumor incidence. (420magazine.com)
  • Twenty-six aberrant crypt foci displayed dysplasia as evident by histologic analysis. (nih.gov)
  • Aberrant crypt foci form before colorectal polyps and are one of the earliest changes seen in the colon that may lead to cancer. (wikipedia.org)
  • Results showed that DMH induced 100% aberrant crypt foci (ACF) and polyps which were significantly reduced in the IMF-8 treated group. (elsevier.com)
  • These results show that aberrant methylated genes can be detected frequently in sporadic colon polyps and that they can be detected in fecal DNA. (aacrjournals.org)
  • The focus is composed of 3 hyperplastic crypts that are much wider then surrounding normal crypts. (intechopen.com)
  • Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. (wikipedia.org)
  • ACF in colonic mucosa stained with toluidine blue is usually darker and larger than normal crypt foci and tend to occur in isolation, in pairs or in small clusters. (scielo.br)
  • Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. (bioportfolio.com)
  • Under such conditions, dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat distal colon. (greenmedinfo.com)
  • Research on diet in breast cancer survival has been focused on single nutrients or foods, particularly dietary fat, fruits, vegetables, fiber, and alcohol. (google.com)
  • and group C (seven ACF, 8.3%) including foci with enlarged, crowded and stratified nuclei, mucin depletion, frequent mitoses, and evident dysplasia, diffuse or focal (mild in five cases, moderate in two) representing microadenomas. (nih.gov)
  • The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons of experimental animals exposed to colon carcinogens could be identified and quantified in the human colon. (nih.gov)
  • Finally, hyperplastic foci were significantly larger than foci of group A and C. Group B ACF were also more frequent in the rectum than in the colon. (nih.gov)
  • Oral doses of 80 and 160 mg/kg body weight of propolis or 10mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively. (propolisscience.org)
  • CpG island methylation in aberrant crypt foci of the colorectum. (nih.gov)
  • Frequent and characteristic K- ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon (1994) Yamashita Naoyuki et al. (naver.com)
  • This finding could be concluded that purple rice extracts inhibited aberrant colonic epithelial cell progression via apoptosis induction. (biomedsearch.com)
  • compared with control (C-). In relation to the weight of the organs, the groups LIN and LINCA showed higher values for the liver and kidney compared with control (C-). Regarding ACF, the group LINCA presented fewer ACF in the middle and distal colon compared with control (C-). When we analyzed ACF with more than three crypts the group LIN and LINCA did not present ACF in the middle and distal segments. (isciii.es)
  • Aberrant crypts are characterized by irregularly shaped glands (crypts), with enlarged luminal opening and cell hyperplasia. (scielo.br)
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
  • CpG island DNA methylation is an epigenetic mechanism that represses gene transcription in a variety of normal cellular processes including imprinting and X-chromosome inactivation, but it becomes excessive and aberrant in many neoplasms. (aacrjournals.org)
  • The aberrant DNA methylation affects CpG-rich regions, called "CpG islands," in the 5′ region of genes and results in transcriptional silencing through complex effects on transcription factor binding and associated changes in chromatin structure. (aacrjournals.org)
  • On the right there are hyperplastic aberrant crypts of rat colorectal mucosa, induced by carcinogen. (intechopen.com)
  • A lacto probiotic product reduced up to 79.82% the induction of aberrant crypt foci by 1,2-dimethylhydrazine. (greenmedinfo.com)
  • The focus is composed of 3 crypts with slight mucin depletion. (intechopen.com)
  • The focus is composed of 3 crypts that show severe mucin depletion. (intechopen.com)
  • 50], crypt morphology characteristics, and histology) of ACF and to correlate such characteristics with the intervention (vs placebo). (clinicaltrials.gov)
  • These findings suggest that the semi-synthetic iminoflavones, IMF-8, effectively inhibit DMH-induced ACFs and colonic crypts by alleviating the oxidative stress and suppressing the inflammation. (elsevier.com)