Aberrant Crypt Foci
Azoxymethane
Precancerous Conditions
1,2-Dimethylhydrazine
Carcinogens
Colon
Anticarcinogenic Agents
Intestinal Mucosa
Colonic Diseases
Elettaria
Colorectal Neoplasms
Genes, APC
Nucleolus Organizer Region
Chenopodiaceae
Amorphophallus
Norisoprenoids
Etodolac
Inulin
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Rutin
Aesculus
Mucins
Genes, ras
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Piroxicam
Plant Extracts
Adenomatous Polyposis Coli
Colonic Polyps
Intestinal Polyps
Intestine, Large
Cecum
Methylene Blue
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
DNA Adducts
Cyclooxygenase 2
Dietary Fiber
Body Weight
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Ornithine Decarboxylase
Aminobiphenyl Compounds
Intestine, Small
Imidazoles
Random Allocation
Dextran Sulfate
Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
Rats, Wistar
Hyperplasia
Cell Transformation, Neoplastic
Drug Screening Assays, Antitumor
Glutathione Transferase
Disease Models, Animal
Cell Division
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Rats, Sprague-Dawley
Prostaglandin-Endoperoxide Synthases
Nitric Oxide Synthase Type II
Immunohistochemistry
Carcinoma
Feces
Dose-Response Relationship, Drug
Mutation
Antioxidants
Isoenzymes
Intestinal Polyposis
Focus Groups
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Liver
Bifidobacterium
Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats. (1/38)
(+info)Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice. (2/38)
(+info)Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. (3/38)
(+info)Sodium butyrate does not decrease the evolution of precancerous lesions in rats. (4/38)
(+info)Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum by boiled garlic powder. (5/38)
The scavenging capacity of reactive oxygen species, such as hydroxyl radicals, is reported not to decrease in boiled garlic (an odorless garlic preparation). We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum. Male F344 rats (5 weeks old) were fed a basal diet, or experimental diets containing 5% or 1% BGP for 5 weeks. One week later, all rats were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). At 10 weeks of age, all the rats were sacrificed, and the colorectum was evaluated for MDF and ACF. In rats given DMH and the 5% or 1% BGP diets (Groups 2 and 3), the numbers of MDF decreased significantly in a dose-dependent manner, compared with the DMH and basal diet value (Group 1) (p<0.01). The numbers of ACF in Group 2, but not Group 3, showed a non-significant tendency to decrease. Next, the effects of BGP on the formation of DMH-induced O6-methylguanine (O6-MeG) DNA adducts in rats were studied. Male F344 rats (5 weeks old) were fed the basal diet, or 10% BGP diet for 5 weeks. All rats were injected i.p. once with 40 mg/kg DMH at the end of week 5. The animals were sacrificed 6 hours after DMH injection to analyze the O6-MeG DNA adducts in the colorectal mucosa. Dietary administration of BGP significantly inhibited the O6-MeG DNA adduct levels in the colorectal mucosa, compared with the controls (p<0.01). These results suggested that BGP may exert chemopreventive effects against colon carcinogenesis at least in the initiation stage. (+info)Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention. (6/38)
(+info)Histomorphology of aberrant crypt foci in colorectal carcinoma. (7/38)
Colorectal carcinogenesis is a complex multistep process that includes changes in histomorphological appearance of the colonic mucosa and changes at molecular level. Aberrant crypt foci (ACF) was first described by Bird in 1987 on examination of methylene-blue-stained colonic mucosa of azoxymethane-treated mice under light microscopy. Since then ACF was considered as the earliest preneoplastic change that can be seen in the colonic mucosa. The aim of this study was to look at the histomorphology and distribution of ACF in colorectal carcinoma. 50 formalin-fixed archival colectomy specimens for colorectal carcinoma were examined under light microscopy after staining with 0.2% methylene blue. ACF was identified by larger and darker crypts with thickened epithelium, and often elevated from adjacent normal mucosa. ACF was found in 41 of 50 colectomy specimens examined. There were 328 ACF consisting of 36 (11.0%) ACF without hyperplasia or dysplasia, 263 (80.2%) ACF with hyperplasia and 29 (8.8%) ACF with dysplasia. Of these 29 ACF with dysplasia, 25 showed low grade dysplasia and four high grade dysplasia. The density of ACF was higher in the left colon, those older than 65 years of age and among males but these findings were statistically not significant. The crypt multiplicity of hyperplastic ACF (30.149, SD 28.395) was larger than dysplastic ACF (20.613, SD 40.128). The spectrum of histological changes observed probably represent the evolution of ACF in colorectal carcinogenesis. (+info)Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps. (8/38)
(+info)
The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded...
Cancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer
Foci of Aberrant Crypts in the Colons of Mice and Rats Exposed to Carcinogens Associated with Foods | Cancer Research
Thais make rice stem cell serum from Thai Rice
Physiological and stem cell compartmentalization in the adult Drosophila midgut
Calcium May Cut Risk for Precancerous Colon Lesions in Some People - Drugs.com MedNews
Non-polypoid (flat) colon lesions associated with colorectal cancer - NetDoc
Colon Lesion - DrugBank
Quick Answer: How To Cook Purple Thai Rice? - Szechuan House-Lutherville
Detailed Course Information
Minimally Invasive Colorectal Resection Is Associated with Significantly Elevated Levels of Plasma Matrix Metalloproteinase 3 ...
Aberrant Epithelial GREM1 Expression Promotes Stem-Cell Plasticity and Ectopic Crypt Formation in the Pathogenesis of Familial...
Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet<...
Allyl sulfur compounds from garlic modulate aberrant crypt formation.
Flaxseed Meal As Replacement For Flour | Flaxseed Meal
Chemopreventive Effect of Amorphophallus campanulatus (Roxb.) Blume Tuber Against Aberrant Crypt Foci and Cell Proliferation in...
Meat Processing and Colon Carcinogenesis: Cooked, Nitrite-Treated, and Oxidized High-Heme Cured Meat Promotes Mucin-Depleted...
Flaxseed Same Flaxseed Meal | Flaxseed Meal
The nutritional value of flaxseed meal for swine
Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT | Read by QxMD
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition |...
Flaxseed meal? - VeggieBoards
Research | Azim Lab - Salk Institute for Biological Studies
View source for Powerful curves - Soft-Matter
TRANSLATIONAL IMPACT | Disease Models & Mechanisms
Maruti 800 Accessories in India | Price of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv Accessory | Vicky.in
MDF (Raw MDF, Supawood) By Shanghai SNSWOOD International Trading Co, LTD., China
Prevention by aspirin and its combination with α-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci...
flaxseed oil Archives - Medicinal Plants Information
Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in...
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) - Full Text...
How to Cook Thai Rice Sticks - Worth The Whisk
01.09 Myeloid cells drive early inflammation and orchestrate salivary glands tertiary lymphoid structures formation in a model...
Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane...
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Thai imported rice to feed Indonesia
agriculture crops sap reservoir for iran polymer in iran | manufacturer of polyacrylamide for water treatment industrial
Central Asian Beef Pilaf
Calories in Flaxseed Pizza Crust - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Calories in flax bread - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Crypt::OpenPGP - finding and using preferred SK algorithm
Choosing Between Plywood, Hardboard, MDF and Particleboard for Your Projects / Rockler How-to
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.* - Propolis Science
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise | Gut
Banana Chocolate Chip Oat Flaxseed Almond Muffins Recipe
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Plus it
What world price?
Rice Flour
LACTATION COOKIES recipe | Epicurious.com
Flax Seeds for Weight Loss: Benefits and How to Use Them
Hot Cereal Time of Year
File php7-crypt-tests.patch of Package php72 -
Open Build Service
ORPHAN BLACK - SEASON 2 - CULTURE CRYPT
Piceid
Resveratrol glucoside from transgenic alfalfa prevents aberrant crypt foci in mice. Resveratroloside (3,5,4'-trihydroxystilbene ... "Resveratrol from Transgenic Alfalfa for Prevention of Aberrant Crypt Foci in Mice". Nutrition and Cancer. 62 (3): 351-361. doi: ...
KRAS
Pretlow TP, Pretlow TG (November 2005). "Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer?". ...
Orlistat
"Aberrant crypt foci of the colon as precursors of adenoma and cancer". N Engl J Med. 339 (18): 1277-84. doi:10.1056/ ... 2-dimethylhydrazine produced significantly higher numbers of aberrant crypt foci (ACF) colon lesions than did the carcinogen ...
Cooking
July 1992). "Promotion of aberrant crypt foci and cancer in rat colon by thermolyzed protein". J. Natl. Cancer Inst. 84 (13): ...
Stem cell marker
June 2005). "Metallothionein crypt-restricted immunopositivity indices (MTCRII) correlate with aberrant crypt foci (ACF) in ... crypt-restricted immunopositivity indices (MTCRII) monosomy 7 Mouse orthologue of ARX MRP4 Msi-1 Musashi Musashi-1 Mutant BCRP ...
HPG80
"Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM". American Journal ... "Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts ...
Microcystin
... in drinking water enhance the growth of aberrant crypt foci in the mouse colon". Journal of Toxicology and Environmental Health ...
Sodium-coupled monocarboxylate transporter 1
... is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. ... 2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary ...
ACF
... human gene Aberrant crypt foci, a preneoplastic lesion on the mucosa of colon or rectum Antecubital fossa, part of the ...
Licopeno, a enciclopedia libre
... on colonic aberrant crypt foci formation in rats". Cancer Lett 107 (1): 137-142. PMID 8913278. doi:10.1016/0304-3835(96)04354-6 ...
Likopen - Википедија, слободна енциклопедија
... on colonic aberrant crypt foci formation in rats.". Cancer Lett. 107 (1): 137-142. PMID 8913278. doi:10.1016/0304-3835(96)04354 ...
லிகோபீன் - தமிழ் விக்கிப்பீடியா
... on colonic aberrant crypt foci formation in rats.". Cancer Lett 107 (1): 137-142. ...
Aberrant crypt foci
... (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...
奧利司他 - 维基百科,自由的百科全书
Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y. Aberrant crypt foci of ... Aberrant crypt foci,ACF)的數量顯著增加[26]。異常腺窩病灶為大腸癌的
Lükopeen - Vikipeedia, vaba entsüklopeedia
... on colonic aberrant crypt foci formation in rats. - Cancer Lett, 1996, kd 107, nr 1, lk 137-142. Resümee. Resümee. ...
Category:Pathology
Aberrant crypt foci. *Aphasiology. *Apoplexy. *Atypia. *Atypical small acinar proliferation. B. *Banff Classification ...
બદામ - વિકિપીડિયા
"Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis". Cancer Lett. 165 (1): 27 ...
마이크로시스틴 - 위키백과, 우리 모두의 백과사전
... in drinking water enhance the growth of aberrant crypt foci in the mouse colon". 《Journal of Toxicology and Environmental ...
DNMT1
Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. DNA methyltransferase ... "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". ... crypt expansion and altered differentiation timing of ISCs, and proliferation and maintenance of MaSCs. GRCh38: Ensembl release ... to form a complex at replication foci". Nature Genetics. 25 (3): 269-77. doi:10.1038/77023. PMID 10888872. S2CID 26149386. Kim ...
Field cancerization
Almost every crypt in all tissue samples from this patient showed high expression of KU86. However, the majority of crypts in ... Field defects associated with gastrointestinal tract cancers also commonly displayed reduced apoptosis competence, aberrant ... These initial molecular changes may subsequently progress to cytologically recognizable premalignant foci of dysplasia, and ... The crypts with reduced or absent expression of ERCC1 or PMS2 usually occurred in large patches of adjacent crypts. Both ERCC1 ...
Colorectal cancer
Abnormal (aberrant) methylation occurs as a normal consequence of normal aging and the risk of colorectal cancer increases as a ... The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell. The most commonly ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ...
Carcinogenesis
Aberrant DNA methylation patterns - hypermethylation and hypomethylation compared to normal tissue - have been associated with ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ... natural selection of a mutant or epigenetically altered cell among the stem cells at the base of one of the intestinal crypts ... Loss of that methylation can induce the aberrant expression of oncogenes, leading to cancer pathogenesis. Known mechanisms of ...
Albinism in popular culture
In 2009, two African American albinistic fashion models, Shaun Ross and Diandra Forrest, were the focus of an episode of the ... ISBN 978-0-7607-3979-2. "Tales From the Urban Crypt". New York Daily News Online. Archived from the original on 15 May 2008. ... aberrant even before his experimentation, he subsequently became completely deranged. Albino bias is also alleged in modern ... and his albinism is not the central focus of his character. (While his name, or lack thereof, seems to indicate otherwise, all ...
Somatic evolution in cancer
Studies of this issue have focused mainly at the gene mutation level, as copy number variation, LOH and specific chromosomal ... leading to the accumulation of aberrant cells. Most mammalian cells can replicate a limited number of times due to progressive ... predispose to clonal expansions that encompass large numbers of crypts in some conditions such as Barrett's esophagus. He also ... Many of the somatic evolutionary studies have traditionally been focused on clonal expansion, as recurrent types of changes can ...
Freud and Philosophy
ISBN 0-262-54057-6. Dufresne, Todd (2000). Tales From the Freudian Crypt: The Death Drive in Text and Context. Stanford, ... ISBN 0-333-48638-2. Genosko, Gary (2002). Félix Guattari: An Aberrant Introduction. London: Continuum. ISBN 0-8264-6034-8. ... who nevertheless found its approach to interpretation limited by its focus on the ideas of symbol and double meaning, Richard ...
Colorectal cancer
The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell.[37][38][39] The most ... aberrant) methylation occurs as a normal consequence of normal aging and the risk of colorectal cancer increases as a person ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ...
Stem-cell niche
Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between ... In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the ... Gout, Stéphanie; Huot, Jacques (2008). "Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer". Cancer ... "Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging". Nature. 507 (7492): 362-5. Bibcode: ...
Induced stem cells
However, some genetically normal iPSCs failed to produce all-iPSC mice because of aberrant epigenetic silencing of the ... Shifting the focus from internal reprogramming to external forcing". Ageing Research Reviews. 12 (1): 29-38. doi:10.1016/j.arr. ... from Intestinal Crypts". Cell Reports. 6 (6): 1046-1058. doi:10.1016/j.celrep.2014.02.013. PMC 4245054. PMID 24613355. Hendry, ...
Aberrant crypt foci - Wikipedia
Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...
CpG island methylation in aberrant crypt foci of the colorectum. - PubMed - NCBI
Histology of aberrant crypt foci in the human colon
Aberrant crypt foci (ACF) have been identified in the methylene-blue stained mucosa of the human colon. Some lines of evidence ... Histology of aberrant crypt foci in the human colon Histopathology. 1997 Apr;30(4):328-34. doi: 10.1046/j.1365-2559.1997.d01- ... Aberrant crypt foci (ACF) have been identified in the methylene-blue stained mucosa of the human colon. Some lines of evidence ... Finally, hyperplastic foci were significantly larger than foci of group A and C. Group B ACF were also more frequent in the ...
Aberrant crypt foci of the colon as precursors of adenoma and cancer. - PubMed - NCBI
All 20 subjects had aberrant crypt foci at base line.. RESULTS: We identified 3155 aberrant crypt foci, 161 of which were ... correlations between the number of aberrant crypt foci, the presence of dysplastic foci, the size of the foci, and the number ... Aberrant crypt foci of the colon as precursors of adenoma and cancer.. Takayama T1, Katsuki S, Takahashi Y, Ohi M, Nojiri S, ... Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied mainly in ...
Identification and quantification of aberrant crypt foci and microadenomas in the human colon
The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons ... Twenty-six aberrant crypt foci displayed dysplasia as evident by histologic analysis. In these instances we feel the term ... Identification and quantification of aberrant crypt foci and microadenomas in the human colon Hum Pathol. 1991 Mar;22(3):287-94 ... The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons ...
DNA damage and aberrant crypt foci as putative biomarkers to evaluate
... the chemopreventive effect of annatto (Bixa orellana L.) ... dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat ... on the formation of aberrant crypt foci (ACF) induced by dimethylhydrazine (DMH) in rat colon. Further, we investigate, the ... Conversely, annatto was successful in inhibiting the number of crypts/colon (animal), but not in the incidence of DMH-induced ...
Cancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we ... Keywords: aberrant crypt foci; biomarker; colon cancer; chemoprevention aberrant crypt foci; biomarker; colon cancer; ... Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer. Michael J. Wargovich * , Vondina R. Brown. ... Wargovich, M.J.; Brown, V.R.; Morris, J. Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer. Cancers ...
The Role, Significance and Applicability of Aberrant Crypt Foci in Clinical Practice | IntechOpen
Significance and Applicability of Aberrant Crypt Foci in Clinical Practice , IntechOpen, Published on: 2014-03-12. Authors: ... Aberrant crypts can be observed as single altered crypt or as a cluster of altered crypts that form a focus termed ACF [8; 14; ... Dysplastic aberrant crypts of human colorectal mucosa accompanying FAP (left). The focus is composed of 4 crypts. The level of ... Figure 3. Dysplastic aberrant crypts of human colorectal mucosa accompanying FAP (left). The focus is composed of 4 crypts. The ...
Pathology Outlines - Aberrant crypt foci (ACF) in colon
Crypts are 2 - 3x larger and more dilated than normal crypts, may have a foci of dysplasia * ACF can be subclassified as ... Cite this page: Jain S. Aberrant crypt foci (ACF) in colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/ ... Endoscopy: aberrent cryptic foci are stained darker than normal crypts with Methylene blue using high magnification ...
Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats
... observed for foci with up to 4 crypts, but not for foci with 5 or more crypts. This may be explained by the fact that foci with ... Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats1 ... The emergence of aberrant crypt foci (ACF) is one of the most important outcome parameters in such models2. ... 5. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa, K, Miyake H, Niitsu Y. Aberrant crypt foci ...
Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in...
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) - Full Text...
Changes in Total Aberrant Crypt Foci (ACF) Number [ Time Frame: Baseline to 30 days ]. Changes in total aberrant crypt foci ( ... values found in rectal aberrant crypt foci (ACF) tissue. *Post-treatment in Prostaglandin E2 (PGE2) Within Aberrant Crypt Foci ... Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci). This study has ... Aberrant Crypt Foci. Substance-Related Disorders. Chemically-Induced Disorders. Mental Disorders. Precancerous Conditions. ...
CiNii 論文 -
Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced...
Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid MAGNUSON B. A. ... Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon * * MORISHITA ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer BIRD R. P. ... Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats PEREIRA M. A. ...
Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm | Cancer...
Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm. Eiji Sakai, ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm ...
Somatic APC and K-ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons | Cancer Research
Somatic APC and K-ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark ... Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, ... ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark Penner, Kazy Hay, ... ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark Penner, Kazy Hay, ...
The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics...
The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics ... The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics ... we found that HQT inhibits azoxymethane-induced aberrant crypt foci (ACF) formation in a preneoplastic colonic ACF rat model. ...
Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon...
Aberrant crypt foci AgNORs Pronyl-lysine Cell proliferation Chemoprevention This is a preview of subscription content, log in ... Bird RP (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93:55-71PubMed ... Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon ... Agner AR, Bazo AP, Ribeiro LR, Salvadori DM (2005) DNA damage and aberrant crypt foci as putative biomarkers to evaluate the ...
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats | Cancer Research
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats Velmurugan ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ...
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)
Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon of mice increasing the gene expression of p53
GOMIDES, Antônio Frederico de Freitas et al. Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon ... Palavras-chave : Defatted flaxseed; Aberrant crypt foci; P53 protein; Bifidobacterium spp. · resumo em Espanhol · texto em ... goal of this study was to investigate the preventive effects of defatted flaxseed meal on the appearance of aberrant crypt foci ... When we analyzed ACF with more than three crypts the group LIN and LINCA did not present ACF in the middle and distal segments ...
Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa...
Then, the CEE was used to determine the effects on the progression of aberrant crypt foci (ACF), a preneoplastic lesion seen in ... Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa ... Rats fed with only the high dose of CEE had significantly decreased numbers of ACF per rat (45.56%) and crypt multiplicity (AC/ ... This finding could be concluded that purple rice extracts inhibited aberrant colonic epithelial cell progression via apoptosis ...
β-Ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-α in...
... of one crypt foci, 41% of two crypt foci, 18% of three crypt foci, and 21% of four or more crypt foci (Fig. 4A ). Rats fed β- ... Aberrant crypt multiplicity was determined as the number of crypts in each focus and categorized as containing up to four or ... A, normal crypt (10×), one crypt to four or more crypts (4×), and five crypts ACF (20×). B, effect of β-ionone on azoxymethane- ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71. ...
Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial | Cancer Prevention Research
1 to 9 crypts; medium, 10 to 19 crypts; and large, 20 crypts or more per focus; ref. 22; Fig. 1). All ACF were recorded ... Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial. Kunihiro Hosono, Hiroki Endo, Hirokazu ... Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998;339:1277-84. ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71. ...
The combination of 1α, 25(OH)<sub>2</sub> - Vitamin D<sub>3</sub>, calcium and acetylsalicyclic acid affects azoxymethane...
The combination of 1α, 25(OH)2 - Vitamin D3, calcium and acetylsalicyclic acid affects azoxymethane-induced aberrant crypt foci ... The combination of 1α, 25(OH)2 - Vitamin D3, calcium and acetylsalicyclic acid affects azoxymethane-induced aberrant crypt foci ... The combination of 1α, 25(OH)2 - Vitamin D3, calcium and acetylsalicyclic acid affects azoxymethane-induced aberrant crypt foci ... on development of aberrant crypt foci (ACF) and tumours in colon were examined in groups of 16 male F344 rats initiated with ...
HD Chromoendoscopy Coupled with DNA Mass Spectrometry Profiling Identifies Somatic Mutations in Microdissected Human Proximal...
"Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention" and "Aberrant crypt foci in the ... Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention. Cancer Prev Res 2008;1:4-8. ... Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control 2012;23:355-61. ... Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis 2007;28:769-76 ...
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation :...
Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane...
Keywords: ACF, aberrant crypt foci; AOM, azoxymethane; DMH, 1,2-dimethylhydrazine; FAA, focal areas of atypism; H&E, ... Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen ... Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen ...
Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients | BMC Cancer | Full Text
Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC ... Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients. *Marek Kowalczyk1. , ... Aberrant crypt foci (ACF) were first described by Bird in mice exposed to a mutagenic agent - azoxymethane in 1987 [1]. ... Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasm. Am J ...
The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded...
Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with ... methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate ... Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with ... Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila). 2010;3(9):1077-83. ...
Frontiers | Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis | Oncology
Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell ... Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell ... Aberrant Crypt Foci. Aberrant crypt foci (ACF) were induced using AOM and DSS. Six-week-old female Wt and Prom1-/- mice (N = 5 ... Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate ...
Stained mucosaLesionsRatsCarcinogenesisCell proliferationAdenomasColon cancerAdenomaMucosalBiomarkerMiceEpithelial cellsTotal number of aberrantMethyleneFingerprintHuman colonicFormationHistologicPolypsNormal cryptsClustersDietaryDysplasiaColonsSignificantlyColorectum1994ApoptosisDistalHyperplasiaMethylationHyperplasticInductionMucin depletionHistologyInflammation0.0001
Stained mucosa1
- Aberrant crypt foci (ACF) have been identified in the methylene-blue stained mucosa of the human colon. (nih.gov)
Lesions15
- Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied mainly in surgical specimens from patients who already had colon cancer. (nih.gov)
- Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. (aacrjournals.org)
- ACF are tiny lesions that develop in the earliest stage of colorectal carcinogenesis and consist of large, thick crypts identified by dense methylene blue staining ( 18 - 21 ). (aacrjournals.org)
- Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM). (oup.com)
- Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). (biomedcentral.com)
- Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate biomarker of CRC. (biomedcentral.com)
- Aberrant crypt foci (ACF) are microscopic lesions of the colonic mucosa suspected of being preneoplastic, and their investigation has been advocated to evaluate the cause-effect relationship between putative risk factors and CRC. (aacrjournals.org)
- Aberrant crypt foci (ACF) are grossly unidentifiable lesions of the colon and visible only with low- power microscopic examinations after methylene blue stain . (bvsalud.org)
- natalensis Berger (designated as 'ALOE') on azoxymethane (AOM)-induced aberrant crypt foci (ACF), putative preneoplastic lesions, in the rat colorectum. (fujita-hu.ac.jp)
- Aims of the study: To investigate whether tomatoes and onions,with low or high quercetin-glycoside content, could reduce azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF), preneoplastic lesions in the colon of rats. (wur.nl)
- aberrant crypt foci (ACF) are colon preneoplastic lesions that can be used as a tool to study preventive processes for colorectal cancer (CRC). (isciii.es)
- We therefore investigated whether a 1-year administration of different l -carnitine concentrations (0, 1, 2 and 5 g/l) via drinking water leads to an increased incidence of preneoplastic lesions (so-called aberrant crypt foci ) in the colon of Fischer 344 rats as well as to the appearance of atherosclerotic lesions in the aorta of these animals. (springer.com)
- In this paper, we investigated the involvement of endocannabinoids on the formation of aberrant crypt foci (ACF, earliest preneoplastic lesions) in the colon mouse in vivo. (420magazine.com)
- Development of colon cancer is a multistep process involving a series of pathological alterations ranging from discrete microscopic mucosal lesions, like aberrant crypt foci (ACF), to malignant tumors [2]. (420magazine.com)
- ACF are early focal lesions of the colonic mucosa composed of one to several enlarged crypts, which are specifically induced by colon carcinogens [3]. (420magazine.com)
Rats11
- Our aim was to study the chemopreventive efficacy of pronyl-lysine, a key antioxidant present in bread crust by evaluating, the total number of aberrant crypt foci (ACF), their distributions, dysplastic ACF, colonic tumor incidence and the expression of cell proliferation biomarker such as the argyrophilic nucleolar organizing region-associated proteins (AgNORs) in 1,2-dimethylhydrazine (DMH) induced colon cancer in rats. (springer.com)
- Deeptha K, Kamaleeswari M, Sengottuvelan M, Nalini N (2006) Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats. (springer.com)
- The present study is an attempt to investigate the dose-dependent effect of dietary silibinin on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation in Fisher 344 male rats. (aacrjournals.org)
- Then, the CEE was used to determine the effects on the progression of aberrant crypt foci (ACF), a preneoplastic lesion seen in colon carcinogenesis in rats. (biomedsearch.com)
- Rats fed with only the high dose of CEE had significantly decreased numbers of ACF per rat (45.56%) and crypt multiplicity (AC/focus) (16.67%) compared to rats that received DMH alone. (biomedsearch.com)
- Effects of 1alpha,25(OH)(2)-vitamin D(3) and acetylsalicylic acid at various dietary levels of calcium (CaCO(3)) on development of aberrant crypt foci (ACF) and tumours in colon were examined in groups of 16 male F344 rats initiated with azoxymethane and observed for 16 weeks. (dtu.dk)
- Colons of 10 rats from each dietary group were analyzed for aberrant crypt foci (ACF), which are preneoplastic markers. (uoi.gr)
- Colonic mucosal proliferation, aberrant crypt foci (ACF) induction, and fecal bile acids, parameters connected to the risk of colon cancer development, were studied in female F344 rats treated with starch or sucrose boluses or with a sucrose diet. (naver.com)
- In additional experiments, colon cell proliferation (MF/crypt) was higher in rats given boluses of sucrose three times per week for 40 days after AOM (20 mg/kg) [5.9 ± 0.7 (SE)] than in rats given starch boluses (2.96 ± 0.4) or fed sucrose continuously (3.6 ± 0.5). (naver.com)
- This study investigatedthe effects of Amorphophallus campanulatus tuber methanolic extract (ACME) on aberrant crypt foci (ACF)formation, colonic cell proliferation, lipid peroxidative damage and the antioxidant status in a long term preclinicalmodel of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in rats. (waocp.org)
- In this study, the chemopreventive potential of Cranberry was analyzed in reducing the Aberrant Crypt Foci (ACF) induced by Azoxymethane (AOM) in Fisher 344 male rats. (cranberryinstitute.org)
Carcinogenesis10
- Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation has been described as an important molecular pathway. (nih.gov)
- DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. (greenmedinfo.com)
- Sengottuvelan M, Viswanathan P, Nalini N (2006) Chemopreventive effect of trans-resveratrol-a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis. (springer.com)
- We tested the in vivo chemopreventive efficacy in rat colon carcinogenesis model using aberrant crypt foci (ACF) as endpoint marker. (aacrjournals.org)
- We also examine the chemopreventive efficacy of β-ionone on azoxymethane-induced rat colon carcinogenesis model using colonic aberrant crypt foci (ACF) as endpoint biomarker. (aacrjournals.org)
- Objective To study the effect of macrophage migration inhibitory factor(MIF) antibody on the rat colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine ( DMH ), carcinoma number and expression of MIF in rat colonic carcinogenesis . (bvsalud.org)
- Blume Tuber Against Aberrant Crypt Foci and Cell Proliferation in 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis', Asian Pacific Journal of Cancer Prevention , 14(9), pp. 5331-5339. (waocp.org)
- The aim of this study was to investigate the effects of the commercial disperse dye product containing the CI Disperse Blue 291 on rat colon carcinogenesis, evaluated by the single cell gel assay (comet assay) and by aberrant crypt foci development. (usp.br)
- Inoculation with La reduced the severity of colonic carcinogenesis caused by CT-26 cells, such as level of colonic involvement and structural abnormality of epithelial/crypt damage. (cambridge.org)
- Moreover, analysis of preneoplastic aberrant crypt foci from high-risk patients suggests that acquisition of the high-COX-2/low-cPLA 2 phenotype may arise at an early stage of colon carcinogenesis. (aacrjournals.org)
Cell proliferation4
- Cell proliferation was higher in animals treated with a single sucrose bolus than in those given a starch bolus (15 g/kg body wt), with 4.3 ± 0.64 and 2.17 ± 0.57 (SE) mitotic figures (MF) per crypt in the sucrose and starch bolus groups, respectively (p (naver.com)
- The excised colons were evaluated for aberrant crypt foci (ACF) formation, cell proliferation (PCNA assay), apoptosis (TUNEL assay), and iNOS and COX-2 expression. (tamu.edu)
- Generalized disruption of Wnt signaling in the intestine resulted in widespread loss of crypts with the absence of cell proliferation in the small intestine, indicating an essential role for this pathway in the maintenance of intestinal stem cells and their dividing descendents. (pnas.org)
- This reduction in aberrant crypt foci (ACF) was accompanied by suppression of cell proliferation (mean Brdu LI in carcinogen control=13.91+/-3.31, and 0.5% cardamom=2.723+/-0.830) and induction of apoptosis (mean AI in carcinogen control=1.547+/-0.42 and 0.5% cardamom=6.61+/-0.55). (sigmaaldrich.com)
Adenomas9
- 0.001) correlations between the number of aberrant crypt foci, the presence of dysplastic foci, the size of the foci, and the number of adenomas. (nih.gov)
- Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell compartment and in early intestinal adenomas. (frontiersin.org)
- Aberrant crypt foci (ACF) are putative precursors of colorectal adenomas and have been postulated as a potential biomarker for colorectal cancer. (wustl.edu)
- To determine the effect of the study drugs (aspirin [acetylsalicylic acid] + DFMO) and placebo with respect to proliferation (Ki67 labeling index), apoptosis (caspase-3 expression assay), and drug effect markers (COX-1, -2, polyamines, PGE2) from adenomas, aberrant crypt focus (ACF) and normal-appearing mucosa using pre- and 12-month post-intervention tissue biopsy samples. (clinicaltrials.gov)
- I. To explore the effects of the study agents on a focused panel of tissue biomarkers in pre- and post-intervention biopsy samples from recurrent adenomas, rectal ACF, and adjacent normal-appearing mucosa among subjects enrolled in the phase II clinical trial. (clinicaltrials.gov)
- 15 However, while microsatellite instability (MSI) may be established at an early stage in adenoma formation, including microscopic aberrant crypt foci, 2 16 17 mutated genes have not been detected at high frequency in adenomas showing MSI. (bmj.com)
- The adenoma to carcinoma sequence is characterized by recognizable histologic changes that start with dysplastic aberrant crypt foci and benign tubular adenomas. (aacrjournals.org)
- The aberrant methylation of certain tumor suppressor genes, such as CDKN2A , has been reported in colonic adenomas and aberrant crypt foci (7-9) . (aacrjournals.org)
- The Aspirin/Folate Polyp Prevention Study reported that folic acid supplementation at 1 mg/day for 6-10 years significantly increased the risk of recurrence of advanced and multiple colorectal adenomas [15] and of prostate cancer [16] in predisposed subjects with prior colorectal adenomas who likely harboured preneoplastic foci. (plos.org)
Colon cancer6
- Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. (mdpi.com)
- This phase II trial is studying how well curcumin works in preventing colon cancer in smokers with aberrant crypt foci. (clinicaltrials.gov)
- Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa L. var. (biomedsearch.com)
- The density of aberrant crypt foci (ACF), the earliest identifiable mucosal abnormality, may serve as a surrogate marker for colon cancer risk, but has rarely been studied in the proximal colon. (aacrjournals.org)
- Herein, we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using azoxymethane (AOM)-induced colon cancer mice model. (oup.com)
- Thermolyzed casein in particular has shown to cause the growth of aberrant crypt foci (ACF tumors) and colon cancer. (mercola.com)
Adenoma8
- Aberrant crypt foci of the colon as precursors of adenoma and cancer. (nih.gov)
- Using magnifying endoscopy, we studied the prevalence, number, size, and dysplastic features of aberrant crypt foci and their distribution according to age in 171 normal subjects, 131 patients with adenoma, and 48 patients with colorectal cancer. (nih.gov)
- We also prospectively examined the prevalence of aberrant crypt foci in 11 subjects (4 normal subjects, 6 with adenoma, and 1 with cancer) before and after the administration of 100 mg of sulindac three times a day for 8 to 12 months and compared the results with those in 9 untreated subjects (4 normal subjects and 5 with adenoma). (nih.gov)
- Aberrant crypt foci, particularly those that are large and have dysplastic features, may be precursors of adenoma and cancer. (nih.gov)
- Hyperplastic aberrant crypts of human (left) colorectal mucosa accompanying resected sporadic colorectal adenoma. (intechopen.com)
- Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis (2001) Takayama Tetsuji et al. (naver.com)
- An aberrant crypt focus obtains a KRAS mutation and progresses to an early adenoma. (brainscape.com)
- Determine the aberrant crypt foci (ACF) and adenoma burden in the entire colorectum of these patients. (clinicaltrials.gov)
Mucosal4
- Aberrant crypt foci (ACF) are morphologically identifiable mucosal abnormalities, a subset of which may be precancerous and contribute to a "field defect" within the mucosa ( 5 ). (aacrjournals.org)
- The intestinal tract is lined by mucosa, which is primarily composed of villi or the intercrypt table and epithelial-lined crypts at the mucosal base ( 1 - 4 ). (frontiersin.org)
- The mucosal epithelial cells arise from intestinal stem cells located in the crypt ( 5 ). (frontiersin.org)
- The histopathological images of the IMF-8 treated colon showed no signs of mucosal crypt abscess. (elsevier.com)
Biomarker1
- Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. (aacrjournals.org)
Mice5
- Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. (wikipedia.org)
- The goal of this study was to investigate the preventive effects of defatted flaxseed meal on the appearance of aberrant crypt foci (ACF) in mice treated with 1,2-dimethylhydrazine (DMH). (isciii.es)
- Aberrant crypt foci (ACF) were first described by Bird in mice exposed to a mutagenic agent - azoxymethane in 1987 [ 1 ]. (biomedcentral.com)
- In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. (fujita-hu.ac.jp)
- Journal Article] Lack of enhancing effects of degraded λ-carrageenan on the development of β-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane. (nii.ac.jp)
Epithelial cells2
- The epithelial cells of the hyperplastic crypts are higher and composed of one layer. (intechopen.com)
- The epithelial cells covering the aberrant crypts are classified as mild dysplasia. (intechopen.com)
Total number of aberrant1
- Results indicate that feeding of lactulose and B. longum singly and in combination reduces the number of ACF (P = 0.0001) and the total number of aberrant crypts significantly (P = 0.0005). (uoi.gr)
Methylene2
- When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. (wikipedia.org)
- There was a close correlation between the number of crypts per ACF in each specimen as scored by methylene-blue and histologic examination. (nih.gov)
Fingerprint1
- Fingerprint Dive into the research topics of 'Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. (fujita-hu.ac.jp)
Human colonic1
- Carcinoembryonic antigen in human colonic aberrant crypt foci (1994) Pretlow Theresa P et al. (naver.com)
Formation8
- In the present study, we evaluate the activity of annatto (Bixa orellana L.), a natural food colorant rich in carotenoid, on the formation of aberrant crypt foci (ACF) induced by dimethylhydrazine (DMH) in rat colon. (greenmedinfo.com)
- Here, we found that HQT inhibits azoxymethane-induced aberrant crypt foci (ACF) formation in a preneoplastic colonic ACF rat model. (rsc.org)
- 0.001) reduces the total number and crypt multiplicity of AOM-induced ACF formation in a dose-dependent manner. (aacrjournals.org)
- Furthermore, we showed that metformin suppressed the azoxymethane-induced formation of colorectal aberrant crypt foci (ACF) by activating AMPK ( 17 ). (aacrjournals.org)
- Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon. (propolisscience.org)
- Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. (fujita-hu.ac.jp)
- 7 crypts) decreased with increasing dose of FaOH and FaDOH and that this inhibitory effect on early neoplastic formation of ACF was dose-dependent, which was also the case for the total number of macroscopic neoplasms. (aau.dk)
- Notably, N-arachidonoylserotonin completely prevented the formation of ACF with four or more crypts, which have been show to be best correlated with final tumor incidence. (420magazine.com)
Histologic1
- Twenty-six aberrant crypt foci displayed dysplasia as evident by histologic analysis. (nih.gov)
Polyps3
- Aberrant crypt foci form before colorectal polyps and are one of the earliest changes seen in the colon that may lead to cancer. (wikipedia.org)
- Results showed that DMH induced 100% aberrant crypt foci (ACF) and polyps which were significantly reduced in the IMF-8 treated group. (elsevier.com)
- These results show that aberrant methylated genes can be detected frequently in sporadic colon polyps and that they can be detected in fecal DNA. (aacrjournals.org)
Normal crypts1
- The focus is composed of 3 hyperplastic crypts that are much wider then surrounding normal crypts. (intechopen.com)
Clusters3
- Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. (wikipedia.org)
- ACF in colonic mucosa stained with toluidine blue is usually darker and larger than normal crypt foci and tend to occur in isolation, in pairs or in small clusters. (scielo.br)
- Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. (bioportfolio.com)
Dietary2
- Under such conditions, dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat distal colon. (greenmedinfo.com)
- Research on diet in breast cancer survival has been focused on single nutrients or foods, particularly dietary fat, fruits, vegetables, fiber, and alcohol. (google.com)
Dysplasia1
- and group C (seven ACF, 8.3%) including foci with enlarged, crowded and stratified nuclei, mucin depletion, frequent mitoses, and evident dysplasia, diffuse or focal (mild in five cases, moderate in two) representing microadenomas. (nih.gov)
Colons1
- The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons of experimental animals exposed to colon carcinogens could be identified and quantified in the human colon. (nih.gov)
Significantly2
- Finally, hyperplastic foci were significantly larger than foci of group A and C. Group B ACF were also more frequent in the rectum than in the colon. (nih.gov)
- Oral doses of 80 and 160 mg/kg body weight of propolis or 10mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively. (propolisscience.org)
Colorectum1
- CpG island methylation in aberrant crypt foci of the colorectum. (nih.gov)
19941
- Frequent and characteristic K- ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon (1994) Yamashita Naoyuki et al. (naver.com)
Apoptosis1
- This finding could be concluded that purple rice extracts inhibited aberrant colonic epithelial cell progression via apoptosis induction. (biomedsearch.com)
Distal1
- compared with control (C-). In relation to the weight of the organs, the groups LIN and LINCA showed higher values for the liver and kidney compared with control (C-). Regarding ACF, the group LINCA presented fewer ACF in the middle and distal colon compared with control (C-). When we analyzed ACF with more than three crypts the group LIN and LINCA did not present ACF in the middle and distal segments. (isciii.es)
Hyperplasia2
Methylation2
- CpG island DNA methylation is an epigenetic mechanism that represses gene transcription in a variety of normal cellular processes including imprinting and X-chromosome inactivation, but it becomes excessive and aberrant in many neoplasms. (aacrjournals.org)
- The aberrant DNA methylation affects CpG-rich regions, called "CpG islands," in the 5′ region of genes and results in transcriptional silencing through complex effects on transcription factor binding and associated changes in chromatin structure. (aacrjournals.org)
Hyperplastic1
- On the right there are hyperplastic aberrant crypts of rat colorectal mucosa, induced by carcinogen. (intechopen.com)
Induction1
- A lacto probiotic product reduced up to 79.82% the induction of aberrant crypt foci by 1,2-dimethylhydrazine. (greenmedinfo.com)
Mucin depletion2
- The focus is composed of 3 crypts with slight mucin depletion. (intechopen.com)
- The focus is composed of 3 crypts that show severe mucin depletion. (intechopen.com)
Histology1
- 50], crypt morphology characteristics, and histology) of ACF and to correlate such characteristics with the intervention (vs placebo). (clinicaltrials.gov)
Inflammation1
- These findings suggest that the semi-synthetic iminoflavones, IMF-8, effectively inhibit DMH-induced ACFs and colonic crypts by alleviating the oxidative stress and suppressing the inflammation. (elsevier.com)
0.00011
- 0.0001) of foci containing four or more aberrant crypts. (aacrjournals.org)