Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.Colonic Neoplasms: Tumors or cancer of the COLON.Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Rats, Inbred F344Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Dimethylhydrazines: Hydrazines substituted with two methyl groups in any position.Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Hydroxyeicosatetraenoic Acids: Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Adenoma: A benign epithelial tumor with a glandular organization.Color Perception Tests: Type of vision test used to determine COLOR VISION DEFECTS.Endoscopy, Gastrointestinal: Endoscopic examination, therapy or surgery of the gastrointestinal tract.Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Pathology: A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Societies, Scientific: Societies whose membership is limited to scientists.Azo CompoundsToxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.Silymarin: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.Milk Thistle: The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.Chemoprevention: The use of chemical compounds to prevent the development of a specific disease.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Epidemiologic Studies: Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.Cyclooxygenase 2 Inhibitors: A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.Cyclooxygenase Inhibitors: Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Cyclooxygenase 2: An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.Sulfonamides: A group of compounds that contain the structure SO2NH2.Pyrazoles: Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats. (1/38)

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Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice. (2/38)

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Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. (3/38)

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Sodium butyrate does not decrease the evolution of precancerous lesions in rats. (4/38)

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Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum by boiled garlic powder. (5/38)

The scavenging capacity of reactive oxygen species, such as hydroxyl radicals, is reported not to decrease in boiled garlic (an odorless garlic preparation). We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum. Male F344 rats (5 weeks old) were fed a basal diet, or experimental diets containing 5% or 1% BGP for 5 weeks. One week later, all rats were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). At 10 weeks of age, all the rats were sacrificed, and the colorectum was evaluated for MDF and ACF. In rats given DMH and the 5% or 1% BGP diets (Groups 2 and 3), the numbers of MDF decreased significantly in a dose-dependent manner, compared with the DMH and basal diet value (Group 1) (p<0.01). The numbers of ACF in Group 2, but not Group 3, showed a non-significant tendency to decrease. Next, the effects of BGP on the formation of DMH-induced O6-methylguanine (O6-MeG) DNA adducts in rats were studied. Male F344 rats (5 weeks old) were fed the basal diet, or 10% BGP diet for 5 weeks. All rats were injected i.p. once with 40 mg/kg DMH at the end of week 5. The animals were sacrificed 6 hours after DMH injection to analyze the O6-MeG DNA adducts in the colorectal mucosa. Dietary administration of BGP significantly inhibited the O6-MeG DNA adduct levels in the colorectal mucosa, compared with the controls (p<0.01). These results suggested that BGP may exert chemopreventive effects against colon carcinogenesis at least in the initiation stage.  (+info)

Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention. (6/38)

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Histomorphology of aberrant crypt foci in colorectal carcinoma. (7/38)

Colorectal carcinogenesis is a complex multistep process that includes changes in histomorphological appearance of the colonic mucosa and changes at molecular level. Aberrant crypt foci (ACF) was first described by Bird in 1987 on examination of methylene-blue-stained colonic mucosa of azoxymethane-treated mice under light microscopy. Since then ACF was considered as the earliest preneoplastic change that can be seen in the colonic mucosa. The aim of this study was to look at the histomorphology and distribution of ACF in colorectal carcinoma. 50 formalin-fixed archival colectomy specimens for colorectal carcinoma were examined under light microscopy after staining with 0.2% methylene blue. ACF was identified by larger and darker crypts with thickened epithelium, and often elevated from adjacent normal mucosa. ACF was found in 41 of 50 colectomy specimens examined. There were 328 ACF consisting of 36 (11.0%) ACF without hyperplasia or dysplasia, 263 (80.2%) ACF with hyperplasia and 29 (8.8%) ACF with dysplasia. Of these 29 ACF with dysplasia, 25 showed low grade dysplasia and four high grade dysplasia. The density of ACF was higher in the left colon, those older than 65 years of age and among males but these findings were statistically not significant. The crypt multiplicity of hyperplastic ACF (30.149, SD 28.395) was larger than dysplastic ACF (20.613, SD 40.128). The spectrum of histological changes observed probably represent the evolution of ACF in colorectal carcinogenesis.  (+info)

Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps. (8/38)

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*Aberrant crypt foci

... (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...

*KRAS

Pretlow TP, Pretlow TG (November 2005). "Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer?". ...

*Piceid

Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Resveratroloside ... "Resveratrol from Transgenic Alfalfa for Prevention of Aberrant Crypt Foci in Mice". Nutrition and Cancer. 62 (3): 351-361. doi: ...

*Orlistat

"Aberrant crypt foci of the colon as precursors of adenoma and cancer" (PDF). N Engl J Med. 339 (18): 1277-84. doi:10.1056/ ... 2-dimethylhydrazine produced significantly higher numbers of aberrant crypt foci (ACF) colon lesions than did the carcinogen ...

*Cooking

July 1992). "Promotion of aberrant crypt foci and cancer in rat colon by thermolyzed protein". J. Natl. Cancer Inst. 84 (13): ...

*Stem cell marker

June 2005). "Metallothionein crypt-restricted immunopositivity indices (MTCRII) correlate with aberrant crypt foci (ACF) in ... crypt-restricted immunopositivity indices (MTCRII) monosomy 7 Mouse orthologue of ARX MRP4 Msi-1 Musashi Musashi-1 Mutant BCRP ...

*Microcystin

... in drinking water enhance the growth of aberrant crypt foci in the mouse colon". Journal of Toxicology and Environmental Health ...

*SLC5A8

... is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. ... 2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary ...

*DNMT1

Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. DNA methyltransferase ... "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". ... crypt expansion and altered differentiation timing of ISCs, and proliferation and maintenance of MaSCs. GRCh38: Ensembl release ... to form a complex at replication foci". Nature Genetics. 25 (3): 269-77. doi:10.1038/77023. PMID 10888872. Kim GD, Ni J, ...

*Field cancerization

Almost every crypt in all tissue samples from this patient showed high expression of KU86. However, the majority of crypts in ... Field defects associated with gastrointestinal tract cancers also commonly displayed reduced apoptosis competence, aberrant ... These initial molecular changes may subsequently progress to cytologically recognizable premalignant foci of dysplasia, and ... The crypts with reduced or absent expression of ERCC1 or PMS2 usually occurred in large patches of adjacent crypts. Both ERCC1 ...

*Carcinogenesis

Aberrant DNA methylation patterns - hypermethylation and hypomethylation compared to normal tissue - have been associated with ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ... natural selection of a mutant or epigenetically altered cell among the stem cells at the base of one of the intestinal crypts ... Loss of that methylation can induce the aberrant expression of oncogenes, leading to cancer pathogenesis. Known mechanisms of ...

*Somatic evolution in cancer

Studies of this issue have focused mainly at the gene mutation level, as copy number variation, LOH and specific chromosomal ... leading to the accumulation of aberrant cells. Most mammalian cells can replicate a limited number of times due to progressive ... predispose to clonal expansions that encompass large numbers of crypts in some conditions such as Barrett's esophagus. He also ... Many of the somatic evolutionary studies have traditionally been focused on clonal expansion, as recurrent types of changes can ...

*Stem-cell niche

Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between ... In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the ... Gout, Stéphanie; Huot, Jacques (2008). "Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer". Cancer ... "Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging". Nature. 507 (7492): 362-5. doi: ...

*Induced stem cells

However, some genetically normal iPSCs failed to produce all-iPSC mice because of aberrant epigenetic silencing of the ... Shifting the focus from internal reprogramming to external forcing". Ageing Research Reviews. 12: 29-38. doi:10.1016/j.arr. ... from Intestinal Crypts". Cell Reports. 6: 1046-1058. doi:10.1016/j.celrep.2014.02.013. PMC 4245054 . PMID 24613355. Hendry, C. ...
Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats Denis E. Corpet * , Claire Jacquinet , Ginette Peiffer , Sylviane Taché Xénobiotiques INRA : UR1089 , Ecole Nationale Vétérinaire de Toulouse , FR * Correspondence should be adressed to: Denis Corpet ,[email protected] , Abstract The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were randomized a week later to two groups. Control rats were given 5 days a week a s.c. saline injection, and experimental rats were given ultralente bovine insulin, 20 U/kg. The promoting effect of insulin injections was assessed by the multiplicity (number of crypts) of aberrant crypt foci after 100 d of treatment (72 injections). The rats given insulin ate more and were heavier than controls (215 ± 11 vs. 182 ± 7 g, p,0.001). Insulin ...
Previous studies using conditional Apc knockout mice demonstrated that acute loss of the Apc gene rapidly expands progenitor cells in the intestinal crypts (Sansom et al., 2004; Andreu et al., 2005) but does not lead to crypt fission/branching, suggesting that Wnt activation through loss of Apc is not sufficient to induce de novo crypt formation. In the present study, we showed that high levels of β-catenin activation are sufficient for de novo crypt formation of adult mice (Fig. 2). Our observation suggests that β-catenin activation amplifies ISCs, which is consistent with recent work carried out in Drosophila hindgut (Takashima et al., 2008). The discrepancy between previous reports and our study seems to arise from differences in the levels of Wnt activation. In fact, by titrating down the levels of activated β-catenin, we also failed to induce de novo crypt formation but instead expanded the proliferating progenitor compartment of the crypts (Fig. 5A). These combined findings strongly ...
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
Rice stem cell serum made from the best of Thai rice varieties is rich in antioxidants and essential amino acids that stimulate the growth of skin cells and slow the aging process.
Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, LutterbaughJ, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced bymethylation in human colon aberrant crypt foci and cancers.Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8412-7. Epub 2003 Jun 26. PMID: 12829793 [PubMed - indexed for MEDLINE]. We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has been implicated as a component of an epigenetic mechanism that silences genes in human cancers. Using restriction landmark genome scanning, we performed a global search to identify genes that would be aberrantly methylated at high frequency in human colon cancer. From among 1,231 genomic NotI sites assayed, site 3D41 was identified as methylated in 11 of 12 colon cancers profiled. Site 3D41 mapped to exon 1 of ...
Consuming higher amounts of calcium may lower the likelihood of precancerous colon and rectal lesions in people who are at increased risk due to variations in t
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
OUTLINE: This is a randomized, double-blind, placebo-controlled, chemoprevention study. Patients are stratified according to age (18 to 49 vs 50 and over) and number of rectal aberrant crypt foci (5-9 vs 10 or more).. All patients undergo a baseline biomarker assessment and full colonoscopy to resect all neoplasms, quantitate rectal aberrant crypt foci, and biopsy rectal mucosa.. Depending on the results of the biomarker assessments, patients are randomized to 1 of 2 treatment arms. Patients with no adenomas of 5 mm or greater receive no further treatment.. ...
Principles of Cell and Molecular Biology Study Area IV. Prereq.: BMS 102 or BIO 121; or permission of department chair. Introduction to the major principles of cell biology including cell compartmentalization; flow of genetic information; protein structure, synthesis, and trafficking; signal transduction; and molecular responses resulting in changes in cell activity, cell division, or apoptosis. Three hours of lecture and one, three-hour laboratory per week ...
A total of 73 CRC patients who underwent MICR met the inclusion criteria (34 males /39 female, mean ages 66.3± 12.8 years; 28% rectal and 62% colon lesions). The mean incision length was 7.8 ± 3.6cm and mean length of stay was 6.8± 4.4 days. The final cancer staging breakdown was; Stage I, 27%, Stage II, 33%, stage III, 36% and stage IV, 4%. The mean PreOp MMP3 level was 14.9±7.8 ng/ml (n=73). Significantly elevated mean plasma levels were noted on POD1 (21.4±14.7ng/ml, n= 73, p=, 0.0001), POD3 (37.9±21.5 ng/ml, n= 72, p=, 0.0001), POD7-13 (22.0±13.0 ng/ml, n=56, p=, 0.0001), POD14-20 (21.9±10.3 ng/ml, n=20, p=0.003) and on POD 21-27 (21.9±11.43 ng/ml, n= 20, p=0.002) when compared to PreOp levels. Plasma levels returned to the PreOp baseline at the POD 28-41 time point (n=16, p=0.07).. Conclusion ...
Ingredient Treasury For Gluten-Free BakingFlaxseed Meal: Known for being high in Omega 3 Fatty Acids and fiber, flaxseed meal is a favorable Can you use just
Processed meat intake is associated with colorectal cancer risk, but no experimental study supports the epidemiologic evidence. To study the effect of meat processing on carcinogenesis promotion, we first did a 14-day study with 16 models of cured meat. Studied factors, in a 2 × 2 × 2 × 2 design, were muscle color (a proxy for heme level), processing temperature, added nitrite, and packaging. Fischer 344 rats were fed these 16 diets, and we evaluated fecal and urinary fat oxidation and cytotoxicity, three biomarkers of heme-induced carcinogenesis promotion. A principal component analysis allowed for selection of four cured meats for inclusion into a promotion study. These selected diets were given for 100 days to rats pretreated with 1,2-dimethylhydrazine. Colons were scored for preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF). Cured meat diets significantly increased the number of ACF/colon compared with a no-meat control diet (P = 0.002). Only the cooked ...
Effects Of Ground Flaxseed In Swine Diets On Pig Performance ...(CO) diet or a 15% flaxseed (FS) diet fed for 7, 14, 21, or 28 d prior to slaughter. Flaxseed
The nutritional value of flaxseed meal (FSM), a by-product of the flax crushing industry, has not been evaluated properly for use within swine rations. A series of experiments were conducted to determine the nutritional profile of this novel feed ingredient for pigs.The analysis of FSM revealed that it contains, on a dry matter (DM) basis, 133 g/kg ether extract (EE), 345 g/kg crude protein (CP), 60 g/kg ash, 164 g/kg ADF, 250 g/kg NDF, 102 g/kg crude fibre, 14 g/kg starch and 9 g/kg phosphorus. The gross energy (GE) content of the meal was 5.2 Mcal/kg DM. The ether extract fraction was characterized by, as a percent of total fat, 46.6% á-linolenic acid, an omega-3 fatty acid. Palmitic, stearic, oleic and linoleic acids accounted for 9.5, 4.8, 20.7 and 18.4% of the total fat content respectively. The crude protein content was well balanced for all amino acids with the exception of lysine (4.1% of CP), the level of which falls below that of the requirements for growing pigs (5.3% of CP for pigs ...
Background and aims: The molecular mechanisms underlying the promotion of colorectal carcinogenesis by a high-fat diet (HFD) remain unclear. We investigated the role of the insulin-signal pathway and the c-Jun N-terminal kinase (JNK) pathway, which reportedly play crucial roles in insulin resistance, during colorectal carcinogenesis in the presence of hyperinsulinemia induced by a HFD.. Methods: Azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colonic epithelium were compared between mice fed a normal diet (ND) and mice fed a HFD. A western blot analysis was performed to elucidate the mechanism affecting colorectal carcinogenesis by a HFD.. Results: The number of aberrant crypt foci and the colonic epithelial cell proliferative activity were significantly higher in the HFD group than in the ND group. While the plasma insulin level was significantly higher in the HFD group than in the ND group, a western blot analysis revealed the inactivation of Akt, which is ...
The study shows that one of the ECM proteolytic enzymes, the matrix metalloproteinase MMP9, protects mice that are also deficient for the protease plasmin from developing lethal inflammatory mass lesions in the colon. The lethal lesions develop from microscopic colon lesions caused by the inability of mice lacking functional plasmin to break down fibrin. MMP9 is not expressed in healthy colon mucosa but is delivered to the microscopic lesions in the colons of plasmin-deficient mice by invading inflammatory cells. However, in contrast to the combined lethal effects of MMP9 and plasmin deficiency during colon tissue homeostasis, male mice deficient for both MMP9 and plasmin do not differ from plasmin single-deficient mice in terms of incisional skin wound healing, implying that, under certain circumstances, other proteases are able to substitute for MMP9. ...
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The dose-response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF) and to reduce prostaglandin E2 (PGE2) levels. Starting at either 7 or 22 weeks of age, the rats received aspirin. All rats received two doses of AOM (15 mg/kg each on days 7 and 14) and were killed on day 36. The lowest concentrations of aspirin to prevent ACF or reduce PGE2 levels were 600 and 400 mg/kg, respectively. To evaluate the prevention of tumors, rats received either 0 or 400 mg/kg aspirin for a total of 39 weeks with AOM (30 mg/kg) administered 7 days after the start of treatment. Aspirin had no effect on the yield of colon tumors. In a second experiment, rats started to receive 0, 200, 600 or 1800 mg/kg aspirin or 1000 mg/kg α-difluoromethylornithine (DFMO) +/- aspirin. Eight and 15 days later, all the rats received 15 mg/kg AOM. Eleven weeks later, animals that were receiving the control ...
The protection against colorectal cancer (CRC) by non-steroidal anti-inflammatory drugs (NSAIDs) is in part dependent on inhibition of cyclooxygenase (COX). We compared the efficacy of the non-COX-inhibiting R flurbiprofen (R-FB) with COX-inhibiting sulindac and racemic flurbiprofen (Rac-FB), and determined their effects on apoptosis, in an azoxymethane (AOM)-induced rat CRC model. In experiment 1, groups of rats were given daily drug gavage (R-FB 30 mg/kg, Rac-FB 10 mg/kg and Sulindac 20 mg/kg) for one week, followed by AOM treatment and were killed eight hours later, colons were examined for apoptosis and cell proliferation. In experiment 2, groups of rats were given two AOM treatments, followed by daily drug gavage until they were killed ten weeks later, colons were examined for aberrant crypt foci (ACF) and prostaglandin E 2 production. All drugs significantly enhanced apoptosis and inhibited ACF, irrespective of their COX-inhibiting potency (p,0.01), but sulindac was more potent in ...
Amazon.com : Bobs Red Mill Organic Golden Flaxseed Meal, 16-ounce (Pack of 4) (Package May Vary) : Flaxseeds Spices And Herbs : Grocery & Gourmet Food
The benefits of flaxseed are great in number. For a start of there are lots of good nutrients in each little seed. These include a wide spectrum of vitamins and minerals and lots of really good Omega 3 fats. In fact they have so much Omega 3 that they rival fish as a source of these valuable fats. This is good news if you are a vegan! More good news for vegans is that you can make a very good egg substitute using the gel found in flaxseeds. This gel is also found in the ground meal. It is very easy to use flaxseed meal as an egg substitute. You should also use it if you have an egg allergy.. Another neat thing about flaxseeds is that they contain practically zero amounts of carbohydrate. This is because the stored energy of the seed is in the form of oil. As a result they are great when it comes to producing food to fit in with a low carb diet.. You can use flaxseed meal in the same way that you use flour. This means that it is great for baking. Exchanging part of the flour for flaxseed meal ...
PRIMARY OBJECTIVES:. I. To determine mean percentage change from baseline in prostaglandin E2 (PGE2) within ACF pre and post 30 days of curcumin administration at a specified dose.. SECONDARY OBJECTIVS:. I. To determine mean percentage change from baseline in 5-hydroxy-eicosatetraenoic acid (5-HETE) within ACF pre and post 30 days of curcumin administration at a specified dose.. II. To determine mean percentage change from baseline in PGE2 and 5-HETE within comparison normal mucosa pre and post 30 days of curcumin administration at a specified dose.. III. To quantify corresponding enzyme changes in the cyclooxygenases (COX-1, COX-2,) and lipoxygenase (5-LOX) protein abundance. Semi-quantitative changes in these proteins will be measured by western blotting and correlated with changes in prostaglandins and leukotrienes respectively.. IV. Document changes in total ACF number. V. Determine proliferation by Ki-67 IHC in rectal mucosa pre and post therapy and correlate with changes in ACF number and ...
Follow This cooking class at Lets Get Cookin in Westlake Village was great fun - presented by prolific cookbook author, Hugh Carpenter, we foodies were immersed in Thai recipes, always good eats. Hughs dry sense of humor kept us in
Background Tertiary lymphoid structures (TLS) are leukocytes aggregates forming in non-lymphoid tissues in response to chronic inflammation. Salivary glands (SG) of patients with Sjögrens syndrome (SS) develop TLS characterised by B/T cell compartmentalization, specialised vasculature (HEV), functional B cell activation and local differentiation of autoreactive plasma cells. Although TLS presence in SS SG associates with an aggressive disease progression, the mechanisms triggering their formation in SS are largely unknown. We recently developed a model of inducible TLS formation, breach of self-tolerance and salivary hypofunction upon delivery of a replication-deficient adenovirus-5 (AdV5) into C57BL/6 mice SG. In this model, 3 weeks after infection, we observed fully formed and functional TLS, breach of self-tolerance and loss of salivary function.. Here we characterised the presence, function and relevance in TLS formation of the myeloid compartment in the first month post-infection. ...
Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, individually and in combination, were tested on azoxymethane induced colon carcinogenesis in Sprague-Dawley rats. The effect was observed on aberrant crypt foci (ACF), the preneoplastic lesion. To investigate the mechanism of action of the agents used, cell proliferation and the level of apoptosis were determined and the expression of cyclooxygenase-2 (COX-2) protein was analyzed in the colon. Following treatment, significant inhibition of the level of cell proliferation (P|0.01 in garlic; P|0.001 in tomato and P|0.001 in combination treatment group with respect to the carcinogen control group), significant induction of apoptosis (P|0.01 in garlic treated; P|0.01 in tomato treated and P|0
Introduction: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We performed high-magnification chromoscopic colonoscopy to identify ACF in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACF in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACF were also assessed.. Results: The prevalence of ACF was 64%, 88% and 95%, and the mean number of ACF was 3.6, 6.2 and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. Older age and men had increased prevalence and number of ACF. When ...
Full nutritional breakdown of the calories in Flaxseed Pizza Crust based on the calories and nutrition in each ingredient, including Natures Path Organic FlaxPlus Flaxseed meal, Olive Oil, Egg, fresh, whole, raw, Parmesan Cheese, grated, Baking Powder and the other ingredients in this recipe.
Full nutritional breakdown of the calories in gallett using flax based on the calories and nutrition in each ingredient, including Bobs Red Mill Whole Ground Flaxseed Meal, 2 Tbsp., Egg white, fresh, Fage - 0%, plain, Splenda Packet (1 serving = 1 packet) and the other ingredients in this recipe.
usr/bin/perl -w use Crypt::OpenPGP; use Crypt::OpenPGP::KeyRing; my($keyfile, $email) = @ARGV; my $ring = Crypt::OpenPGP::KeyRing-,new(Filename =, $keyfile); my $pgp = Crypt::OpenPGP-,new(PubRing =, $ring); my $kb = $ring-,find_keyblock_by_uid($email); my $alg = $kb-,preferred_sk_alg; my $crypt = $pgp-,encrypt( Data =, squeamish ossifrage, Recipients =, [ $email ], Armour =, 1, ($alg ? (Cipher =, $alg) : ()), # use default if no preference loc +ated ); print $crypt; exit 0; { package Crypt::OpenPGP::KeyBlock; sub preferred_sk_alg { my $self = shift; use Crypt::OpenPGP::Cipher; my $supported = Crypt::OpenPGP::Cipher-,supported; my @prefs; for my $sig (@{ $self-,get(Crypt::OpenPGP::Signature) }) { if ($sig-,is_primary) { unshift @prefs, @{ $sig-,preferred_sk_alg }; } else { push @prefs, @{ $sig-,preferred_sk_alg }; } } for (@prefs) { return $_ if $supported-,{$_}; } return; } } { package Crypt::OpenPGP::Signature; sub is_primary { my $self = shift; my $packet = $self-,find_subpacket(25); # ...
All sheet goods are not created equal, if your next project calls for these versatile materials, Bill Hylton has some suggestions on what to buy.
Results A single bout of exercise increased the expression and secretion of SPARC in skeletal muscle in both mice and humans. In addition, in an azoxymethane-induced colon cancer mouse model, regular low-intensity exercise significantly reduced the formation of aberrant crypt foci in wild-type mice but not in SPARC-null mice. Furthermore, regular exercise enhanced apoptosis in colon mucosal cells and increased the cleaved forms of caspase-3 and caspase-8 in wild-type mice but not in SPARC-null mice. Culture experiments showed that SPARC secretion from myocytes was induced by cyclic stretch and inhibited proliferation with apoptotic effect of colon cancer cells.. ...
4975 Colon cancer is one of the major causes of cancer mortality in the United States of America. Early detection and prevention are the important alternative approaches to control colon cancer. Recently, substantial attention has been focused on identifying naturally occurring chemopreventive compounds capable of inhibiting early events involved in malignant transformation. Of late, laboratory studies have demonstrated that silibinin exhibits various biological activities and significantly inhibits tumorigenesis at various organ sites in several rodent models. The present study is an attempt to investigate the dose-dependent effect of dietary silibinin on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation in Fisher 344 male rats. In addition, we analyzed the effect of silibinin on cell proliferation and the induction of apoptosis by immunohistochemical staining during AOM-induced ACF formation. Five-week-old male F344 rats were randomly divided into 12 groups and fed AIN-76A control ...
753 Sustained expression of COX-2 in the stromal compartment has been shown to play a crucial role in inflammation-associated gastrointestinal tumorigenesis. We recently reported that both zerumbone (ZER), a sesquiterpene occurring in a zingiberaceous plant found in subtropical countries (1), and (±)-13-hydroxy-10-oxo-trans-11-octadecenoic acid (HOA), a linoleate metabolite produced by corn lipoxygenase, exhibited pronounced efficacy for suppressing LPS-induced COX-2 expression in RAW264.7 mouse macrophages. We showed that a topical application of ZER suppressed DMBA/TPA-induced papilloma development and COX-2 protein expression in mouse skin (1), while oral administration attenuated azoxymethane-induced aberrant crypt foci formation and COX-2 induction in rat colons (2). Both ZER and HOA carry an α,β-unsaturated carbonyl moiety that is potentially susceptible to conjugation with biological nucleophiles, implying that each suppresses COX-2 induction through the regulation of redox-sensitive ...
Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We carried out high-magnification chromoscopic colonoscopy to identify ACFs in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACFs in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACFs were also assessed.. Results: The prevalence of ACF was 64%, 88%, and 95%, and the mean number of ACF was 3.6, 6.2, and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. When differences in the prevalence and number of ACFs among age- ...
Double Bear brands rice flour is produced from high quality and selected species of Thai rice. It is sorted fromthe best rice growing regions and carefully stored and managed in accordance with international standards. Modern production process together with the knowhow that we have accumulated for over 35 years result in the best quality rice flour which meets a wide range of customers needs.. ...
Now I have traded oats for flaxseed meal and chia. Have you tried chia cereal? I reviewed chia seeds last fall (that post is HERE) and I really have enjoyed having them in my diet BUT recently found what I like even better -- Milled Chia -- the texture is much more *cereal*-like and not so seedy to me. ...
Culture Crypt presents the complete and definitive episode guide for Orphan Black, including a summary, synopsis, recap, and review of every episode from Season Two. Orphan Black premiered on BBC America in March of 2013, and stars Tatiana Maslany.
A60 The scientific potential of numerous unique animal models of carcinogenesis has not been fully realized due to our limited ability to monitor tumor growth in vivo. Establishment of a method for the accurate measurement of colon lesion size is needed to both characterize the dynamics of tumor growth and monitor responsiveness to therapeutic interventions. The goal of the present study was to develop an endoscopy-based protocol for the accurate estimation of tumor size in vivo from images obtained during colonoscopic examinations. This technology was established using a unique strain of Multiple Intestinal Neoplasia (Min) mice established at Fox Chase Cancer Center (Apc+/Min-FCCC), which spontaneously develop multiple colorectal tumors. Anesthetized Apc+/Min-FCCC mice received colonoscopic examinations, using a rigid endoscope. The endoscope (1.5 mm diameter) was inserted anally, and high-resolution images of 10 colon adenomas (from 8 animals) were captured using a CCD camera. Lesion size was ...
An object of this class encapsulates a passphrase hashed using the Blowfish-based Unix crypt() hash function, known as bcrypt. This is a subclass of Authen::Passphrase, and this document assumes that the reader is familiar with the documentation for that class.. The crypt() function in a modern Unix actually supports several different passphrase schemes. This class is concerned only with one particular scheme, a Blowfish-based algorithm designed by Niels Provos and David Mazieres for OpenBSD. To handle the whole range of passphrase schemes supported by the modern crypt(), see the from_crypt constructor and the as_crypt method in Authen::Passphrase.. The Blowfish-based crypt() scheme uses a variant of Blowfish called Eksblowfish, for expensive key schedule Blowfish. It has the cryptographic strength of Blowfish, and a very slow key setup phase to resist brute-force attacks. There is a cost parameter to the scheme: the length of key setup is proportional to 2^cost. There is a 128-bit salt. ...
The modulating effect of the combined dietary feeding of β-carotene and perilla oil, which is rich in α- olinolenic acid, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in male F344 rats. Rats received oral administration of β-carotene (0, 50 or 200 mg/kg body weight/day) and fed a basal diet containing either 12% olive oil, 3% perilla oil plus 9% olive oil, or 12% perilla oil. A dose-dependent suppressive effect of perilla oil was found. The numbers of ACF were 42.0 and 18.4% of those of the 12% olive oil-fed controls in the rats fed 3% perilla oil plus 9% olive oil and 12% perilla oil, respectively. The development of ACF was also reduced significantly by the addition of dietary β-carotene in each of the oil-fed groups (P , 0.05, respectively). The suppression by the combination of β-carotene and perilla oil was synergistic, as the numbers of ACF were 12.9 and 8.9% of those of the 12% olive oil-fed controls in β-carotene-treated rats ...
Learn how to make these easy organic lactation cookies to help boost your milk supply. These breastmilk cookies are packed with flaxseed meal, oats, brewers yeast, molasses, and wheat germ
Mustard seeds (MS), which are consumed in considerable amounts by the Japanese people that, interestingly, have the longest life expectancy in the world, are known to contain a number of yet not fully defined but quite powerful anti-oxidants. A suspension of extracted MS was found to suppress oxidized-LDL-induced macrophage respiratory burst in vitro, to prevent growth, and to induce apoptotic death of SW480 cells (a human colon cancer cell line), while no such effects were found for normal 3T3 cells. A diet enriched with MS decreased plasma levels of the lipid peroxidation product malonaldehyde in mice exposed to the colon cancer-inducer azoxymethane (AOM). Such a diet also dose-dependently enhanced the activity of several anti-oxidant enzymes, such as superoxide dismutase (SOD), catalase, and GSH-peroxidase and, moreover, reduced AOM-mediated formation of colon adenomas by about 50%. Further studies are required to detail and explore the beneficial effects of MS and their rich content of ...
Cell cycle variations and DNA aneuploidy, were investigated in different phases of azoxymethane (AOM)-induced colon carcinogenesis in rats by flow cytometry. K-ras gene mutations (transitions Gright curved arrow A) were frequently detected in aberrant crypt foci (ACF) initial pre-neoplastic lesions. The fraction of cells in the G2M-phase of the cell cycle was higher in ACF compared to the normal mucosa of control rats. A similar modification of the cell cycle was found in adenomas and adenocarcinomas but, unexpectedly, also in morphologically normal mucosa from AOM-treated animals indicating that AOM treatment permanently modifies cell cycle control in rat colon mucosa. These alterations, however, were not associated with DNA aneuploidy as reported in human sporadic colorectal cancer, suggesting that tumour development in AOM-treated rats is less dependent on aneuploidy.. ...
So I made these with some minor variations. First of all I doubled their size (made ten) and put them in a muffin tin to bake so I could use them as a sort of breakfast cookie. I ground almonds instead of using almond meal because I couldnt find any locally. I put in about 3 tbsp of ground flaxseed, I used raw sunflower seeds and chopped almonds as my nuts, organic ground coconut instead of flakes and I used baking raisins for the dried fruit. That being said I love the flavor and the texture but they are soft and falling apart just a little. Does everyone else find that they stay soft? Have you tried freezing them and then popping them in the microwave to defrost? I made so many and theyre really just for me to eat one every other day or so and I dont want them to go bad. The flaxseed meal will go bad I think if I dont freeze or at least refrigerate them. Im thinking I need a better binder so maybe soaking the ground flaxseed in a bit of juice before combining it with the ingredients might ...
So I made these with some minor variations. First of all I doubled their size (made ten) and put them in a muffin tin to bake so I could use them as a sort of breakfast cookie. I ground almonds instead of using almond meal because I couldnt find any locally. I put in about 3 tbsp of ground flaxseed, I used raw sunflower seeds and chopped almonds as my nuts, organic ground coconut instead of flakes and I used baking raisins for the dried fruit. That being said I love the flavor and the texture but they are soft and falling apart just a little. Does everyone else find that they stay soft? Have you tried freezing them and then popping them in the microwave to defrost? I made so many and theyre really just for me to eat one every other day or so and I dont want them to go bad. The flaxseed meal will go bad I think if I dont freeze or at least refrigerate them. Im thinking I need a better binder so maybe soaking the ground flaxseed in a bit of juice before combining it with the ingredients might ...
Melrose Omega Fibre is based on Australian Organic Flaxseed Meal, Licorice Root, Slippery Elm Bark Powder and Aloe Vera Juice Powder. Melrose Omega Fibre supports a gentle cleansing of the intestinal tract and may be taken on a daily basis without the wor
1. Preheat oven to 375ºF. Line or grease 12 muffin cups.. 2. In medium bowl, combine 3/4 cup all-purpose flour, whole-wheat flour, ½ cup brown sugar, flaxseed meal, baking powder, baking soda and salt; set aside.. 3. In large bowl, whisk buttermilk, ½ cup soybean oil, egg and vanilla. Pour into flour mixture; stir until just blended. Stir in blueberries until just blended. Spoon batter into prepared muffin cups, 3/4 full.. 4. In small bowl, mix remaining 2 T. all-purpose flour, 2 T. brown sugar and 1 T. soybean oil. Sprinkle over muffins.. 5. Bake 18-22 minutes until muffin edges and tops are golden.. ...
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Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats http://www.ncbi.nlm.nih.gov/pubmed/23368917
Purpose: Colon cancer is a major cause of cancer deaths. Dietary factors contribute substantially to the risk of this malignancy. Western-style diets promote development of azoxymethane-induced colon cancer. Although we showed that epidermal growth factor receptors (EGFR) controlled azoxymethane tumorigenesis in standard fat conditions, the role of EGFR in tumor promotion by high dietary fat has not been examined.. Experimental Design: A/J × C57BL6/J mice with wild-type Egfr (Egfrwt) or loss-of-function waved-2 Egfr (Egfrwa2) received azoxymethane followed by standard (5% fat) or western-style (20% fat) diet. As F1 mice were resistant to azoxymethane, we treated mice with azoxymethane followed by one cycle of inflammation-inducing dextran sulfate sodium to induce tumorigenesis. Mice were sacrificed 12 weeks after dextran sulfate sodium. Tumors were graded for histology and assessed for EGFR ligands and proto-oncogenes by immunostaining, Western blotting, and real-time PCR.. Results: Egfrwt mice ...
What foods support lactation? Oats, alfalfa, barley, flaxseed meal, brewers yeast, almonds, papaya, ginger, and chickpeas just to name a few. What about herbal supplements? Fenugreek, milk thistle, fennel, chaste berry, goats rue, torbangun and shatavari are herbs with proven galactogogues. Even the Journal of the American Pharmacists Association (1) recognizes that these products, while not FDA regulated with pharmacodynamics, pharmacokinetics, and dosing, are widely used within the breast-feeding community, often with success. The Journal of Applied Biosciences recognizes that botanical galactogogues have both chemical and antimicrobial properties, not only having benefits for lactation, but also helping new mothers with required nutrients, relief from constipation, and prevention of infection (2). ...
Precancerous lesions are areas of tissue with abnormally rapid cell growth. Though many precancerous lesions can be treated, if...
Looking for bony crypt? Find out information about bony crypt. vault or chamber beneath the main level of a church, used as a meeting place or burial place. It undoubtedly developed from the catacombs used by early... Explanation of bony crypt
Flaxseed may be small, but its health benefits are big. It contains numerous salubrious components, with highlighted nutrients being omega-3 fatty acid ALA (alpha-linolenic acid), fiber and lignans.. Omega-3 fatty acids are good fats that may help lower total cholesterol and low-density lipoprotein (LDL or bad) cholesterol levels, reduce inflammation and reduce the risk of certain cancers. Fiber can help relieve constipation, control cholesterol levels and keep you feeling full longer. Flaxseed also contains lignans, which provide antioxidant protection. To ensure you are getting the most benefit out of flaxseed, it must be ground or crushed. This is because the body cannot break down the whole flaxseed to access the omega-3-containing oil. You can purchase flaxseed whole or ground as flaxseed meal. Whole seeds, oftentimes less expensive, can be ground using a coffee grinder or food processor. Once ground, flaxseed should be stored in the refrigerator in an airtight, non-transparent container, ...
1,1-dimethylhydrazine chemical properties, What are the chemical properties of 1,1-dimethylhydrazine 57-14-7, What are the physical properties of 1,1-dimethylhydrazine ect.
In September last year, the European Food safety Authority (EFSA) said in a scientific opinion​​ that current levels of dietary exposure of titanium dioxide posed no health concerns, even though it was unable to set an acceptable daily limit (ADI) due to data limitations.. However, it called for research to fill these data gaps, particularly on the potential effects on the reproductive system which had been flagged as a risk by "a small number"​ of studies.. A spokesperson for EFSA told FoodNavigator it was aware of the study and would consider its relevance "in due course​".. Source: Scientific Reports​. "Food-grade TiO2​ impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon"​. First published online 20 January 2017, DOI: ​10.1038/srep40373​​. Authors: Sarah Bettini, Elisa Boutet-Robinet, Christel Cartier, Christine Coméra et. al.. ...
If you have ever built a cabinet, counter, bench, or table out of medium density fibreboard and then tried to paint it, you probably noticed very quickly that the edges can suck up a lot of paint. This leads to the repeated application of coats of paint or primer to the MDF, until it stops soaking all of your paint. To avoid having the MDF suck up the paint and to keep your primer and paint applications to a minimum, you can quickly and easily seal its raw edges.. ...
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Omega-3s belong to a group of fatty acids known as long-chain polyunsaturated fatty acids. There are three important Omega-3 fatty acids: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA are found in fish, while ALA is found only in plant foods such as flaxseed meal. EPA and DHA omega-3 fatty acids can only be made in a limited capacity in dogs and are even more poorly synthesized in cats. Therefore, supplementing your pets diet with these nutrients can significantly change their levels of health-promoting Omega-3s ...
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MDF Recovery is a technology developer, which is focused on developing a novel and proprietary process to recover fibre from waste Medium Density Fibreboard (MDF). Over 200,000 tons of MDF waste is generated in the UK alone, with it being incinerated or sent to landfill after a single user life. MDF Recovery aims to solve this problem through establishing the UKs first commercial scale MDF recycling facility alongside the licensing of its technology worldwide. The fibres recovered from their novel process can then be re-integrated back into MDF production, or used as feedstock for a variety of high value industrial applications. MDF Recovery offer a better ecological solution for the disposal of MDF which generates a new source of raw materials for the wood and natural fibre industry, in turn reducing the demand on virgin fibre produced from standing forests.. ...
Flaxseed is an ancient food, prized for its healing properties as far back as 650 B.C. Today, most people eat flaxseed because it is a source of healthy...

CpG island methylation in aberrant crypt foci of the colorectum.  - PubMed - NCBICpG island methylation in aberrant crypt foci of the colorectum. - PubMed - NCBI

CpG island methylation in aberrant crypt foci of the colorectum.. Chan AO1, Broaddus RR, Houlihan PS, Issa JP, Hamilton SR, ... Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12000733?dopt=Abstract

Aberrant crypt foci of the colon as precursors of adenoma and cancer.  - PubMed - NCBIAberrant crypt foci of the colon as precursors of adenoma and cancer. - PubMed - NCBI

All 20 subjects had aberrant crypt foci at base line.. RESULTS: We identified 3155 aberrant crypt foci, 161 of which were ... correlations between the number of aberrant crypt foci, the presence of dysplastic foci, the size of the foci, and the number ... Aberrant crypt foci of the colon as precursors of adenoma and cancer.. Takayama T1, Katsuki S, Takahashi Y, Ohi M, Nojiri S, ... Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied mainly in ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9791143?dopt=Abstract

Pathology Outlines - Aberrant crypt foci (ACF) in colonPathology Outlines - Aberrant crypt foci (ACF) in colon

Crypts are 2 - 3x larger and more dilated than normal crypts, may have a foci of dysplasia * ACF can be subclassified as ... Cite this page: Jain S. Aberrant crypt foci (ACF) in colon. PathologyOutlines.com website. http://www.pathologyoutlines.com/ ... Endoscopy: aberrent cryptic foci are stained darker than normal crypts with Methylene blue using high magnification ...
more infohttp://www.pathologyoutlines.com/topic/colontumoraberrantcrypts.html

DNA damage and aberrant crypt foci as putative biomarkers to evaluateDNA damage and aberrant crypt foci as putative biomarkers to evaluate

... the chemopreventive effect of annatto (Bixa orellana L.) ... dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat ... on the formation of aberrant crypt foci (ACF) induced by dimethylhydrazine (DMH) in rat colon. Further, we investigate, the ... Conversely, annatto was successful in inhibiting the number of crypts/colon (animal), but not in the incidence of DMH-induced ...
more infohttp://www.greenmedinfo.com/article/annatto-has-possible-chemopreventive-effects-through-modulation-cryptal-cell-p

Aberrant crypt foci - WikipediaAberrant crypt foci - Wikipedia

Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...
more infohttps://en.wikipedia.org/wiki/Aberrant_crypt_foci

The Role, Significance and Applicability of Aberrant Crypt Foci in Clinical Practice | IntechOpenThe Role, Significance and Applicability of Aberrant Crypt Foci in Clinical Practice | IntechOpen

Significance and Applicability of Aberrant Crypt Foci in Clinical Practice , IntechOpen, Published on: 2014-03-12. Authors: ... Aberrant crypts can be observed as single altered crypt or as a cluster of altered crypts that form a focus termed ACF [8; 14; ... Dysplastic aberrant crypts of human colorectal mucosa accompanying FAP (left). The focus is composed of 4 crypts. The level of ... Figure 3. Dysplastic aberrant crypts of human colorectal mucosa accompanying FAP (left). The focus is composed of 4 crypts. The ...
more infohttps://www.intechopen.com/books/colorectal-cancer-surgery-diagnostics-and-treatment/the-role-significance-and-applicability-of-aberrant-crypt-foci-in-clinical-practice/

Cancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon CancerCancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer

Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we ... Keywords: aberrant crypt foci; biomarker; colon cancer; chemoprevention aberrant crypt foci; biomarker; colon cancer; ... Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer. Michael J. Wargovich * , Vondina R. Brown. ... Wargovich, M.J.; Brown, V.R.; Morris, J. Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer. Cancers ...
more infohttp://www.mdpi.com/2072-6694/2/3/1705/xml

Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar ratsOptimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats

... observed for foci with up to 4 crypts, but not for foci with 5 or more crypts. This may be explained by the fact that foci with ... Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats1 ... The emergence of aberrant crypt foci (ACF) is one of the most important outcome parameters in such models2. ... 5. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa, K, Miyake H, Niitsu Y. Aberrant crypt foci ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000200005

Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)

Phase IIA Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci). Trial Phase:. ... Phase IIA Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00365209/

Somatic APC and K-ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons | Cancer ResearchSomatic APC and K-ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons | Cancer Research

Somatic APC and K-ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark ... Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, ... ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark Penner, Kazy Hay, ... ras Codon 12 Mutations in Aberrant Crypt Foci from Human Colons. Andrew J. Smith, Hartley S. Stern, Mark Penner, Kazy Hay, ...
more infohttps://cancerres.aacrjournals.org/content/54/21/5527?ijkey=867e29ceaf610e60c5959da9c88bcf1160c55bff&keytype2=tf_ipsecsha

Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) - Full Text...Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) - Full Text...

Changes in Total Aberrant Crypt Foci (ACF) Number [ Time Frame: Baseline to 30 days ]. Changes in total aberrant crypt foci ( ... values found in rectal aberrant crypt foci (ACF) tissue. *Post-treatment in Prostaglandin E2 (PGE2) Within Aberrant Crypt Foci ... Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci). This study has ... Aberrant Crypt Foci. Substance-Related Disorders. Chemically-Induced Disorders. Mental Disorders. Precancerous Conditions. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00365209

CiNii 論文 - 
 		
 		
 			
 		 	
 		 		
 		 			Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced...CiNii 論文 - Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced...

Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid MAGNUSON B. A. ... Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon * * MORISHITA ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer BIRD R. P. ... Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats PEREIRA M. A. ...
more infohttp://ci.nii.ac.jp/naid/10008080567

Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in...Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in...

Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in ... β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats," BioMed Research ...
more infohttps://www.hindawi.com/journals/bmri/2017/3634915/cta/

Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm | Cancer...Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm | Cancer...

Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm. Eiji Sakai, ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm ... Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm ...
more infohttp://cebp.aacrjournals.org/content/early/2011/08/05/1055-9965.EPI-11-0104

Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats | Cancer ResearchInhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats | Cancer Research

Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats Velmurugan ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ... Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats ...
more infohttp://cancerres.aacrjournals.org/content/67/9_Supplement/4975

Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon...Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon...

Aberrant crypt foci AgNORs Pronyl-lysine Cell proliferation Chemoprevention This is a preview of subscription content, log in ... Bird RP (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93:55-71PubMed ... Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon ... Agner AR, Bazo AP, Ribeiro LR, Salvadori DM (2005) DNA damage and aberrant crypt foci as putative biomarkers to evaluate the ...
more infohttps://link.springer.com/article/10.1007/s10637-008-9122-7

Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa...Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa...

Then, the CEE was used to determine the effects on the progression of aberrant crypt foci (ACF), a preneoplastic lesion seen in ... Apoptosis Induction in Colon Cancer Cell Lines and Alteration of Aberrant Crypt Foci in Rat Colon by Purple Rice (Oryza sativa ... Rats fed with only the high dose of CEE had significantly decreased numbers of ACF per rat (45.56%) and crypt multiplicity (AC/ ... This finding could be concluded that purple rice extracts inhibited aberrant colonic epithelial cell progression via apoptosis ...
more infohttp://www.biomedsearch.com/nih/Apoptosis-Induction-in-Colon-Cancer/24742104.html

β-Ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-α in...β-Ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-α in...

... of one crypt foci, 41% of two crypt foci, 18% of three crypt foci, and 21% of four or more crypt foci (Fig. 4A ). Rats fed β- ... Aberrant crypt multiplicity was determined as the number of crypts in each focus and categorized as containing up to four or ... A, normal crypt (10×), one crypt to four or more crypts (4×), and five crypts ACF (20×). B, effect of β-ionone on azoxymethane- ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71. ...
more infohttp://mct.aacrjournals.org/content/7/1/181

Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial | Cancer Prevention ResearchMetformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial | Cancer Prevention Research

1 to 9 crypts; medium, 10 to 19 crypts; and large, 20 crypts or more per focus; ref. 22; Fig. 1). All ACF were recorded ... Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial. Kunihiro Hosono, Hiroki Endo, Hirokazu ... Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998;339:1277-84. ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995;93:55-71. ...
more infohttp://cancerpreventionresearch.aacrjournals.org/content/3/9/1077

Abstract A12: Validity of aberrant crypt foci using as a surrogate biomarker for colorectal cancer | Cancer Prevention ResearchAbstract A12: Validity of aberrant crypt foci using as a surrogate biomarker for colorectal cancer | Cancer Prevention Research

Abstract A12: Validity of aberrant crypt foci using as a surrogate biomarker for colorectal cancer. Eiji Sakai, Hirokazu ... Introduction: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the ... Abstract A12: Validity of aberrant crypt foci using as a surrogate biomarker for colorectal cancer ... Abstract A12: Validity of aberrant crypt foci using as a surrogate biomarker for colorectal cancer ...
more infohttp://cancerpreventionresearch.aacrjournals.org/content/4/10_Supplement/A12

HD Chromoendoscopy Coupled with DNA Mass Spectrometry Profiling Identifies Somatic Mutations in Microdissected Human Proximal...HD Chromoendoscopy Coupled with DNA Mass Spectrometry Profiling Identifies Somatic Mutations in Microdissected Human Proximal...

"Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention" and "Aberrant crypt foci in the ... Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention. Cancer Prev Res 2008;1:4-8. ... Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control 2012;23:355-61. ... Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis 2007;28:769-76 ...
more infohttp://mcr.aacrjournals.org/content/12/6/823.full?ijkey=nMuq199a4b22g&keytype=ref&siteid=aacrjnls

HD Chromoendoscopy Coupled with DNA Mass Spectrometry Profiling Identifies Somatic Mutations in Microdissected Human Proximal...HD Chromoendoscopy Coupled with DNA Mass Spectrometry Profiling Identifies Somatic Mutations in Microdissected Human Proximal...

"Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention" and "Aberrant crypt foci in the ... Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention. Cancer Prev Res 2008;1:4-8. ... Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control 2012;23:355-61. ... Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis 2007;28:769-76 ...
more infohttps://mcr.aacrjournals.org/content/12/6/823

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation :...Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation :...

Herein, we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using ... Herein, we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using ...
more infohttp://oxfordindex.oup.com/view/10.1093/carcin/bgn246

Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane...Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane...

Keywords: ACF, aberrant crypt foci; AOM, azoxymethane; DMH, 1,2-dimethylhydrazine; FAA, focal areas of atypism; H&E, ... Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen ... Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen ...
more infohttp://oxfordindex.oup.com/view/10.1093/carcin/21.8.1567

Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients | BMC Cancer | Full TextOccurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients | BMC Cancer | Full Text

Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC ... Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients. *Marek Kowalczyk1. , ... Aberrant crypt foci (ACF) were first described by Bird in mice exposed to a mutagenic agent - azoxymethane in 1987 [1]. ... Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasm. Am J ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4100-8?optIn=true
  • When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. (wikipedia.org)
  • Under such conditions, dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat distal colon. (greenmedinfo.com)
  • Recently, substantial attention has been focused on identifying naturally occurring chemopreventive compounds capable of inhibiting early events involved in malignant transformation. (aacrjournals.org)
  • Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. (wikipedia.org)
  • Aberrant crypt foci (ACF) were first described by Bird in mice exposed to a mutagenic agent - azoxymethane in 1987 [ 1 ]. (biomedcentral.com)
  • Aberrant crypt foci form before colorectal polyps and are one of the earliest changes seen in the colon that may lead to cancer. (wikipedia.org)
  • 0.001) reduces the total number and crypt multiplicity of AOM-induced ACF formation in a dose-dependent manner. (aacrjournals.org)
  • Conversely, annatto was successful in inhibiting the number of crypts/colon (animal), but not in the incidence of DMH-induced ACF, mainly when administered after DMH. (greenmedinfo.com)
  • Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. (wikipedia.org)
  • Cell proliferation was higher in animals treated with a single sucrose bolus than in those given a starch bolus (15 g/kg body wt), with 4.3 ± 0.64 and 2.17 ± 0.57 (SE) mitotic figures (MF) per crypt in the sucrose and starch bolus groups, respectively (p (naver.com)
  • The emergence of aberrant crypt foci (ACF) is one of the most important outcome parameters in such models 2 . (scielo.br)
  • However, the percentage of "large ACF" (ACF with ≥4 crypts) secreting sialomucins or predominantly sialomucins was higher (p (naver.com)