AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth Care
Aberrant Crypt FociAzoxymethanePrecancerous Conditions1,2-DimethylhydrazineColonic NeoplasmsCarcinogensColonRats, Inbred F344DimethylhydrazinesAnticarcinogenic AgentsIntestinal MucosaSialomucinsColonic DiseasesAdenomaElettariaHistory, Early Modern 1451-1600Colorectal NeoplasmsGenes, APCNucleolus Organizer RegionChenopodiaceaeIntestinal NeoplasmsAmorphophallusNorisoprenoidsCocarcinogenesisEtodolacInulinSulindacRutinAesculusMucinsGenes, rasbeta CateninPiroxicamChemopreventionPlant ExtractsDietAdenomatous Polyposis ColiColonic PolypsIntestinal PolypsIntestine, LargeCecumMethylene BlueDNA AdductsCyclooxygenase 2Dietary FiberRectumBody WeightProliferating Cell Nuclear AntigenOrnithine DecarboxylaseAminobiphenyl CompoundsIntestine, SmallImidazolesColonoscopyRandom AllocationDextran SulfateRats, WistarTerpenesAdenocarcinomaHyperplasiaCell Transformation, NeoplasticDrug Screening Assays, AntitumorGlutathione TransferaseDisease Models, AnimalPhytotherapyCell DivisionAnti-Inflammatory Agents, Non-SteroidalApoptosisRats, Sprague-DawleyMice, Inbred C57BLCell ProliferationProstaglandin-Endoperoxide SynthasesEatingNitric Oxide Synthase Type IIImmunohistochemistryCarcinomaFecesDose-Response Relationship, DrugMutationAntioxidantsIsoenzymesIntestinal PolyposisChoristomaFocus GroupsMice, KnockoutLiverBifidobacteriumTime FactorsAntimutagenic Agents
Aberrant Crypt Foci
Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
Azoxymethane
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
Precancerous Conditions
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
1,2-Dimethylhydrazine
A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
Colonic Neoplasms
Tumors or cancer of the COLON.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Colon
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Rats, Inbred F344
Dimethylhydrazines
Hydrazines substituted with two methyl groups in any position.
Anticarcinogenic Agents
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Intestinal Mucosa
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Sialomucins
A subcategory of mucins that contain SIALIC ACID.
Colonic Diseases
Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
Adenoma
A benign epithelial tumor with a glandular organization.
Elettaria
A plant genus of the family ZINGIBERACEAE, order Zingiberales, subclass Zingiberidae. Elettaria cardamomum (L.) Maton is the source of Cardamom used in SPICES.
History, Early Modern 1451-1600
The period of history from 1451 through 1600 of the common era.
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Genes, APC
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
Nucleolus Organizer Region
The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.
Chenopodiaceae
The goosefoot plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. It includes beets and chard (BETA VULGARIS), as well as SPINACH, and salt tolerant plants.
Intestinal Neoplasms
Tumors or cancer of the INTESTINES.
Amorphophallus
A plant genus of the family ARACEAE. Members contain konjac glucomannan (MANNANS) and SEROTONIN.
Norisoprenoids
Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.
Cocarcinogenesis
The combination of two or more different factors in the production of cancer.
Etodolac
A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
Inulin
A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Rutin
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
Aesculus
A plant genus of the family HIPPOCASTANACEAE (or SAPINDACEAE by some) that contains antimicrobial protein 1 and escin. A. hippocastanum is used in folk medicine for treating chronic venous insufficiency.
Mucins
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Genes, ras
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Piroxicam
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Chemoprevention
The use of chemical compounds to prevent the development of a specific disease.
Plant Extracts
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Diet
Regular course of eating and drinking adopted by a person or animal.
Adenomatous Polyposis Coli
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
Colonic Polyps
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
Intestinal Polyps
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
Intestine, Large
A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.
Cecum
The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.
Methylene Blue
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
DNA Adducts
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Cyclooxygenase 2
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Dietary Fiber
The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.
Rectum
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Ornithine Decarboxylase
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
Aminobiphenyl Compounds
Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
Intestine, Small
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Imidazoles
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Colonoscopy
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Random Allocation
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Dextran Sulfate
Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Terpenes
A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Drug Screening Assays, Antitumor
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Glutathione Transferase
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Phytotherapy
Use of plants or herbs to treat diseases or to alleviate pain.
Cell Division
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Mice, Inbred C57BL
Cell Proliferation
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Prostaglandin-Endoperoxide Synthases
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
Eating
The consumption of edible substances.
Nitric Oxide Synthase Type II
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Feces
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Antioxidants
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Isoenzymes
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Intestinal Polyposis
The growth of INTESTINAL POLYPS. Growth processes include neoplastic (ADENOMA and CARCINOMA) and non-neoplastic (hyperplastic, mucosal, inflammatory, and other polyps).
Choristoma
A mass of histologically normal tissue present in an abnormal location.
Focus Groups
A method of data collection and a QUALITATIVE RESEARCH tool in which a small group of individuals are brought together and allowed to interact in a discussion of their opinions about topics, issues, or questions.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Bifidobacterium
A rod-shaped, gram-positive, non-acid-fast, non-spore-forming, non-motile bacterium that is a genus of the family Bifidobacteriaceae, order Bifidobacteriales, class ACTINOBACTERIA. It inhabits the intestines and feces of humans as well as the human vagina.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Antimutagenic Agents
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.

Optimization of visibility and quantification of aberrant crypt foci in colonic mucosa in Wistar rats. (1/38)

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Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice. (2/38)

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Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. (3/38)

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Sodium butyrate does not decrease the evolution of precancerous lesions in rats. (4/38)

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Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum by boiled garlic powder. (5/38)

The scavenging capacity of reactive oxygen species, such as hydroxyl radicals, is reported not to decrease in boiled garlic (an odorless garlic preparation). We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum. Male F344 rats (5 weeks old) were fed a basal diet, or experimental diets containing 5% or 1% BGP for 5 weeks. One week later, all rats were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). At 10 weeks of age, all the rats were sacrificed, and the colorectum was evaluated for MDF and ACF. In rats given DMH and the 5% or 1% BGP diets (Groups 2 and 3), the numbers of MDF decreased significantly in a dose-dependent manner, compared with the DMH and basal diet value (Group 1) (p<0.01). The numbers of ACF in Group 2, but not Group 3, showed a non-significant tendency to decrease. Next, the effects of BGP on the formation of DMH-induced O6-methylguanine (O6-MeG) DNA adducts in rats were studied. Male F344 rats (5 weeks old) were fed the basal diet, or 10% BGP diet for 5 weeks. All rats were injected i.p. once with 40 mg/kg DMH at the end of week 5. The animals were sacrificed 6 hours after DMH injection to analyze the O6-MeG DNA adducts in the colorectal mucosa. Dietary administration of BGP significantly inhibited the O6-MeG DNA adduct levels in the colorectal mucosa, compared with the controls (p<0.01). These results suggested that BGP may exert chemopreventive effects against colon carcinogenesis at least in the initiation stage.  (+info)

Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention. (6/38)

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Histomorphology of aberrant crypt foci in colorectal carcinoma. (7/38)

Colorectal carcinogenesis is a complex multistep process that includes changes in histomorphological appearance of the colonic mucosa and changes at molecular level. Aberrant crypt foci (ACF) was first described by Bird in 1987 on examination of methylene-blue-stained colonic mucosa of azoxymethane-treated mice under light microscopy. Since then ACF was considered as the earliest preneoplastic change that can be seen in the colonic mucosa. The aim of this study was to look at the histomorphology and distribution of ACF in colorectal carcinoma. 50 formalin-fixed archival colectomy specimens for colorectal carcinoma were examined under light microscopy after staining with 0.2% methylene blue. ACF was identified by larger and darker crypts with thickened epithelium, and often elevated from adjacent normal mucosa. ACF was found in 41 of 50 colectomy specimens examined. There were 328 ACF consisting of 36 (11.0%) ACF without hyperplasia or dysplasia, 263 (80.2%) ACF with hyperplasia and 29 (8.8%) ACF with dysplasia. Of these 29 ACF with dysplasia, 25 showed low grade dysplasia and four high grade dysplasia. The density of ACF was higher in the left colon, those older than 65 years of age and among males but these findings were statistically not significant. The crypt multiplicity of hyperplastic ACF (30.149, SD 28.395) was larger than dysplastic ACF (20.613, SD 40.128). The spectrum of histological changes observed probably represent the evolution of ACF in colorectal carcinogenesis.  (+info)

Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps. (8/38)

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The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded...The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded...
The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide. Therefore, new preventive strategies are needed to lower the burden of this disease. Previous studies reported that aspirin could suppress the development of sporadic colorectal adenoma. In addition, metformin is a biguanide derivative that is long widely used for the treatment of diabetes mellitus and has recently been suggested to have a suppressive effect on carcinogenesis and cancer cell growth. Both drugs exhibit a chemopreventive effect, but their efficacy is limited. Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate biomarker of CRC. Thus, we designed a prospective trial as a preliminary study prior to a CRC chemoprevention trial to evaluate the chemopreventive effect of aspirin combined with metformin on
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07564-z
Cancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon CancerCancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
http://www.mdpi.com/2072-6694/2/3/1705/xml
Foci of Aberrant Crypts in the Colons of Mice and Rats Exposed to Carcinogens Associated with Foods | Cancer ResearchFoci of Aberrant Crypts in the Colons of Mice and Rats Exposed to Carcinogens Associated with Foods | Cancer Research
Aberrant crypt foci can be identified in the colons of rodents treated 3 wk earlier with azoxymethane, a known colon carcinogen. These crypts can easily be visualized in the unsectioned methylene blue-stained colons under light microscopy, where they are distinguished by their increased size, more prominent epithelial cells, and pericryptal space. They occur as single aberrant crypts or as two, three, or four aberrant crypts in a cluster. We compared the reported ability of carcinogens associated with the human diet to induce colon cancer with the measured rate of induction of aberrant crypts in female CF1 mice and Sprague-Dawley rats. The carcinogens used were 1,2-dimethylhydrazine, methyl nitrosourea, N-nitrosodimethylamine, benzo(a)pyrene, aflatoxin B1, 2-amino-6-methyl-dipyrido[1,2-α:3′,2′-d]imidazole, 2-amino-3-methylimidazo[4,5-P]quinoline, 2-amino-3,4-dimethylimidazo[4,5-P]quinoline, and 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Graded doses of these compounds were given to the ...
https://cancerres.aacrjournals.org/content/49/5/1236?ijkey=a7503aeab6246e38fdf095fd6880e9f92e1a8e8c&keytype2=tf_ipsecsha
Thais make rice stem cell serum from Thai RiceThais make rice stem cell serum from Thai Rice
Rice stem cell serum made from the best of Thai rice varieties is rich in antioxidants and essential amino acids that stimulate the growth of skin cells and slow the aging process.
https://biospectrumasia.com/news/56/13825/thais-make-rice-stem-cell-serum-from-thai-rice.html
Physiological and stem cell compartmentalization in the adult Drosophila midgutPhysiological and stem cell compartmentalization in the adult Drosophila midgut
The precise and systematic digestion and subsequent absorption of nutrients in food is vitally important for the life of all metazoans. The intestine is the organ primarily responsible for absorbing, processing, transporting, and excreting the vast variety of nutrients found in an organisms diet, and the tissue is maintained throughout its length by multipotent intestinal stem cells. Although previous work identified regions of preferential copper and iron absorption, only recent work is revealing the degree to which regions of the tissue can be specialized. The work presented in this thesis categorizes the extent of physiological, morphological, organizational and molecular heterogeneity along the intestinal anterior-posterior axis. This work is also the first to test stem cells of specific intestinal regions for their tumorigenic capacity and their ability to generate progeny of neighboring regions. I analyzed the properties of intestinal cells along the anterior-posterior axis and found that ...
https://jscholarship.library.jhu.edu/handle/1774.2/37074
Calcium May Cut Risk for Precancerous Colon Lesions in Some People - Drugs.com MedNewsCalcium May Cut Risk for Precancerous Colon Lesions in Some People - Drugs.com MedNews
Consuming higher amounts of calcium may lower the likelihood of precancerous colon and rectal lesions in people who are at increased risk due to variations in t
https://www.drugs.com/news/calcium-may-cut-risk-precancerous-colon-lesions-some-44062.html
Non-polypoid (flat) colon lesions associated with colorectal cancer - NetDocNon-polypoid (flat) colon lesions associated with colorectal cancer - NetDoc
CHICAGO-Flat, non-polypoid colorectal neoplasms (NP-CRNs), which may be difficult to detect, appear to be relatively common and may have a greater association with cancer compared with the more routinely diagnosed type of colorectal polyps, according to a study in the March 5 issue of JAMA.
https://netdoc.com/non-polypoid-flat-colon-lesions-associated-with-colorectal-cancer/
Colon Lesion - DrugBankColon Lesion - DrugBank
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
https://www.drugbank.ca/indications/DBCOND0113510
Quick Answer: How To Cook Purple Thai Rice? - Szechuan House-LuthervilleQuick Answer: How To Cook Purple Thai Rice? - Szechuan House-Lutherville
Why was purple rice forbidden? Forbidden rice earned its name because it was once reserved for the Chinese emperor to ensure his health and longevity, and
https://www.goszechuanhouse.com/thai-rice/quick-answer-how-to-cook-purple-thai-rice.html
Detailed Course Information
Principles of Cell and Molecular Biology Study Area IV. Prereq.: BMS 102 or BIO 121; or permission of department chair. Introduction to the major principles of cell biology including cell compartmentalization; flow of genetic information; protein structure, synthesis, and trafficking; signal transduction; and molecular responses resulting in changes in cell activity, cell division, or apoptosis. Three hours of lecture and one, three-hour laboratory per week ...
https://ssb.ccsu.edu/pls/ssb_cPROD/bwckctlg.p_disp_course_detail?cat_term_in=200740&subj_code_in=BMS&crse_numb_in=201
Minimally Invasive Colorectal Resection Is Associated with Significantly Elevated Levels of Plasma Matrix Metalloproteinase 3 ...Minimally Invasive Colorectal Resection Is Associated with Significantly Elevated Levels of Plasma Matrix Metalloproteinase 3 ...
A total of 73 CRC patients who underwent MICR met the inclusion criteria (34 males /39 female, mean ages 66.3± 12.8 years; 28% rectal and 62% colon lesions). The mean incision length was 7.8 ± 3.6cm and mean length of stay was 6.8± 4.4 days. The final cancer staging breakdown was; Stage I, 27%, Stage II, 33%, stage III, 36% and stage IV, 4%. The mean PreOp MMP3 level was 14.9±7.8 ng/ml (n=73). Significantly elevated mean plasma levels were noted on POD1 (21.4±14.7ng/ml, n= 73, p=, 0.0001), POD3 (37.9±21.5 ng/ml, n= 72, p=, 0.0001), POD7-13 (22.0±13.0 ng/ml, n=56, p=, 0.0001), POD14-20 (21.9±10.3 ng/ml, n=20, p=0.003) and on POD 21-27 (21.9±11.43 ng/ml, n= 20, p=0.002) when compared to PreOp levels. Plasma levels returned to the PreOp baseline at the POD 28-41 time point (n=16, p=0.07).. Conclusion ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/minimally-invasive-colorectal-resection-is-associated-with-significantly-elevated-levels-of-plasma-matrix-metalloproteinase-3-mmp3-during-the-first-month-after-surgery-which-may-promote-the-growth-o/
Aberrant Epithelial GREM1 Expression Promotes Stem-Cell Plasticity and Ectopic Crypt Formation in the Pathogenesis of Familial...
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https://www.expmedndm.ox.ac.uk/publications/881770
Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet<...Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet<...
TY - JOUR. T1 - Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet. AU - Chihara, Takeshi. AU - Shimpo, Kan. AU - Kaneko, Takaaki. AU - Beppu, Hidehiko. AU - Higashiguchi, Takashi. AU - Sonoda, Shigeru. AU - Tanaka, Miyuki. AU - Yamada, Muneo. AU - Abe, Fumiaki. PY - 2015. Y1 - 2015. N2 - Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt ...
https://pure.fujita-hu.ac.jp/en/publications/dietary-aloe-vera-gel-powder-and-extract-inhibit-azoxymethaneindu
Allyl sulfur compounds from garlic modulate aberrant crypt formation.
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
https://ecnis.openrepository.com/handle/10146/67741
Flaxseed Meal As Replacement For Flour | Flaxseed MealFlaxseed Meal As Replacement For Flour | Flaxseed Meal
Ingredient Treasury For Gluten-Free BakingFlaxseed Meal: Known for being high in Omega 3 Fatty Acids and fiber, flaxseed meal is a favorable Can you use just
http://www.flaxseedmeal.net/flaxseed-meal-as-replacement-for-flour/
Chemopreventive Effect of Amorphophallus campanulatus (Roxb.) Blume Tuber Against Aberrant Crypt Foci and Cell Proliferation in...Chemopreventive Effect of Amorphophallus campanulatus (Roxb.) Blume Tuber Against Aberrant Crypt Foci and Cell Proliferation in...
Colorectal cancer is one of the leading causes of cancer death, both in men and women. This study investigatedthe effects of Amorphophallus campanulatus tuber methanolic extract (ACME) on aberrant crypt foci (ACF)formation, colonic cell proliferation, lipid peroxidative damage and the antioxidant status in a long term preclinicalmodel of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in rats. Male Wistar rats were dividedinto six groups, viz., group I rats served as controls; group II rats treated as drug controls receiving 250 mg/kg body weight of ACME orally; group III rats received DMH (20 mg/kg body weight) subcutaneously once aweek for the first 15 weeks; groups IV, V and VI rats received ACME along with DMH during the initiation,post- initiation stages and the entire period of the study, respectively. All the rats were sacrificed at the end of 30weeks and the intestinal and colonic tissues from different groups were subjected to biochemical and histologicalstudies. Administration of DMH
http://journal.waocp.org/article_28119.html
Meat Processing and Colon Carcinogenesis: Cooked, Nitrite-Treated, and Oxidized High-Heme Cured Meat Promotes Mucin-Depleted...Meat Processing and Colon Carcinogenesis: Cooked, Nitrite-Treated, and Oxidized High-Heme Cured Meat Promotes Mucin-Depleted...
Processed meat intake is associated with colorectal cancer risk, but no experimental study supports the epidemiologic evidence. To study the effect of meat processing on carcinogenesis promotion, we first did a 14-day study with 16 models of cured meat. Studied factors, in a 2 × 2 × 2 × 2 design, were muscle color (a proxy for heme level), processing temperature, added nitrite, and packaging. Fischer 344 rats were fed these 16 diets, and we evaluated fecal and urinary fat oxidation and cytotoxicity, three biomarkers of heme-induced carcinogenesis promotion. A principal component analysis allowed for selection of four cured meats for inclusion into a promotion study. These selected diets were given for 100 days to rats pretreated with 1,2-dimethylhydrazine. Colons were scored for preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF). Cured meat diets significantly increased the number of ACF/colon compared with a no-meat control diet (P = 0.002). Only the cooked ...
https://cancerpreventionresearch.aacrjournals.org/content/3/7/852.short
Flaxseed Same Flaxseed Meal | Flaxseed MealFlaxseed Same Flaxseed Meal | Flaxseed Meal
Effects Of Ground Flaxseed In Swine Diets On Pig Performance ...(CO) diet or a 15% flaxseed (FS) diet fed for 7, 14, 21, or 28 d prior to slaughter. Flaxseed
http://www.flaxseedmeal.net/flaxseed-same-flaxseed-meal/
The nutritional value of flaxseed meal for swine
The nutritional value of flaxseed meal (FSM), a by-product of the flax crushing industry, has not been evaluated properly for use within swine rations. A series of experiments were conducted to determine the nutritional profile of this novel feed ingredient for pigs.The analysis of FSM revealed that it contains, on a dry matter (DM) basis, 133 g/kg ether extract (EE), 345 g/kg crude protein (CP), 60 g/kg ash, 164 g/kg ADF, 250 g/kg NDF, 102 g/kg crude fibre, 14 g/kg starch and 9 g/kg phosphorus. The gross energy (GE) content of the meal was 5.2 Mcal/kg DM. The ether extract fraction was characterized by, as a percent of total fat, 46.6% á-linolenic acid, an omega-3 fatty acid. Palmitic, stearic, oleic and linoleic acids accounted for 9.5, 4.8, 20.7 and 18.4% of the total fat content respectively. The crude protein content was well balanced for all amino acids with the exception of lysine (4.1% of CP), the level of which falls below that of the requirements for growing pigs (5.3% of CP for pigs ...
https://ecommons.usask.ca/handle/10388/etd-07032008-114639
Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT | Read by QxMDPower of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT | Read by QxMD
Colorectal cancer (CRC) is a multistep process that involves adenoma-carcinoma sequence. CRC can be prevented by routine screening, which can detect precancerous lesions. The aim of this study is to clarify whether faecal occult blood test (i-FOBT), tumor M2 pyruvate kinase (t-M2-PK), and endocannabinoid system molecules (cannabinoid receptors type 1-CB1, type 2-CB2, and fatty acid amide hydrolase-FAAH) might represent better diagnostic tools, alone or in combination, for an early diagnosis of CRC. An immunochemical FOB test (i-FOBT) and quantitative ELISA stool test for t-M2-PK were performed in 127 consecutive patients during a 12 month period. Endocannabinoid system molecules and t-M2-PK expression were detected by immunostaining in healthy tissues and normal mucosa surrounding adenomatous and cancerous colon lesions. i-FOBT and t-M2-PK combination leads to a better diagnostic accuracy for pre-neoplastic and neoplastic colon lesions. T-M2-PK quantification in stool samples and in biopsy ...
https://read.qxmd.com/read/28155016/power-of-screening-tests-for-colorectal-cancer-enhanced-by-high-levels-of-m2-pk-in-addition-to-fobt
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition |...Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition |...
Background and aims: The molecular mechanisms underlying the promotion of colorectal carcinogenesis by a high-fat diet (HFD) remain unclear. We investigated the role of the insulin-signal pathway and the c-Jun N-terminal kinase (JNK) pathway, which reportedly play crucial roles in insulin resistance, during colorectal carcinogenesis in the presence of hyperinsulinemia induced by a HFD.. Methods: Azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colonic epithelium were compared between mice fed a normal diet (ND) and mice fed a HFD. A western blot analysis was performed to elucidate the mechanism affecting colorectal carcinogenesis by a HFD.. Results: The number of aberrant crypt foci and the colonic epithelial cell proliferative activity were significantly higher in the HFD group than in the ND group. While the plasma insulin level was significantly higher in the HFD group than in the ND group, a western blot analysis revealed the inactivation of Akt, which is ...
http://gut.bmj.com/content/early/2009/06/30/gut.2009.183624
Flaxseed meal? - VeggieBoardsFlaxseed meal? - VeggieBoards
Im looking for recipes for pumpkin bread/muffins/cookies/[whatever I can make with some canned pumpkin, Bisquick, raisins, cinnamon], and came across
https://www.veggieboards.com/forum/21-general-food-discussions/194897-flaxseed-meal.html
Research | Azim Lab - Salk Institute for Biological StudiesResearch | Azim Lab - Salk Institute for Biological Studies
Cell cycle and cancer. Using time-lapse microscopy, we showed that nuclear envelope (NE) formation is mediated by reshaping of the endoplasmic reticulum and not as previously thought by vesicle fusion. Our results answered a long-standing question in the field of nuclear biology and provided a new paradigm for membrane dynamics. In continuation of this work we recently discovered a remarkable phenomenon whereby the NE becomes transiently ruptured and repaired during interphase in various human cancer cells. Strikingly, NE rupturing was associated with loss of cell compartmentalization and a catastrophic chromosome rearrangement event called chromothripsis and thus might be a source of genomic instability.. Cell differentiation and development. Using Drosophila genetics in combination with imaging and DNA sequencing methods in mouse and human stem cells, we discovered that several NE proteins play an essential role in transcriptional activation of developmentally regulated genes. These findings ...
https://azim.salk.edu/research/
View source for Powerful curves - Soft-Matter
Original entry: Nefeli Georgoulia, APPHY 226, Spring 2009 ==Overview== Authors: L. Mahadevan & T.J. Mitchinson Source: Nature, Vol. 435, 895-896, (2005) Soft Matter key words: polymerization, strain, mechanical bending ==Abstract== This paper is a collaboration between microtubule guru T. Mitchison and biotheorist giant L. Mahadevan. The two join forces to explore past work and to offer novel interpretation to the ever-tantalizing question: How is the chemical energy from GTP hydrolysis harnessed to power growth and shrinkage of microtubules in dynamic instability? Microtubules are part of the cellular cytoskeleton and their structure is that of a hollow tube, formed by the the stacking of thirteen protofilaments. They form a dynamic network through the continuous polymerization and depolymerization of tubulin monomer. This dynamic behavior regulates cell compartmentalization, cellular cargo transportation and perhaps most notably the tearing apart of chromosomes during cell ...
http://soft-matter.seas.harvard.edu/index.php?title=Powerful_curves&action=edit
TRANSLATIONAL IMPACT | Disease Models & MechanismsTRANSLATIONAL IMPACT | Disease Models & Mechanisms
The study shows that one of the ECM proteolytic enzymes, the matrix metalloproteinase MMP9, protects mice that are also deficient for the protease plasmin from developing lethal inflammatory mass lesions in the colon. The lethal lesions develop from microscopic colon lesions caused by the inability of mice lacking functional plasmin to break down fibrin. MMP9 is not expressed in healthy colon mucosa but is delivered to the microscopic lesions in the colons of plasmin-deficient mice by invading inflammatory cells. However, in contrast to the combined lethal effects of MMP9 and plasmin deficiency during colon tissue homeostasis, male mice deficient for both MMP9 and plasmin do not differ from plasmin single-deficient mice in terms of incisional skin wound healing, implying that, under certain circumstances, other proteases are able to substitute for MMP9. ...
http://dmm.biologists.org/content/4/2/226
Maruti 800 Accessories in India | Price of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv Accessory | Vicky.inMaruti 800 Accessories in India | Price of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv Accessory | Vicky.in
Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv, Price of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv, Cost of Maruti 800 Mdf Car Frame Oval - Mdf 1D Shv accessory. See the Price, Image and Description of Maruti 800 car Mdf Car Frame Oval - Mdf 1D Shv.
http://www.vicky.in/accessories/maruti-800-car-mdfcarframeovalmdf1dshv/
MDF (Raw MDF, Supawood) By Shanghai SNSWOOD International Trading Co, LTD., ChinaMDF (Raw MDF, Supawood) By Shanghai SNSWOOD International Trading Co, LTD., China
MDF(Plain MDF) SNSWOOD Specification Dimension: 1220x2440, 1830x2750mmx2.5/3/5/6/8/9/12/15/16/18/22/25mm, 1830x3660mmx16, 18mm Surface: 180#Grid well sanded Formal...
https://www.tradekey.com/product-free/Mdf-raw-Mdf-Supawood--3654790.html
Prevention by aspirin and its combination with α-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci...
The dose-response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF) and to reduce prostaglandin E2 (PGE2) levels. Starting at either 7 or 22 weeks of age, the rats received aspirin. All rats received two doses of AOM (15 mg/kg each on days 7 and 14) and were killed on day 36. The lowest concentrations of aspirin to prevent ACF or reduce PGE2 levels were 600 and 400 mg/kg, respectively. To evaluate the prevention of tumors, rats received either 0 or 400 mg/kg aspirin for a total of 39 weeks with AOM (30 mg/kg) administered 7 days after the start of treatment. Aspirin had no effect on the yield of colon tumors. In a second experiment, rats started to receive 0, 200, 600 or 1800 mg/kg aspirin or 1000 mg/kg α-difluoromethylornithine (DFMO) +/- aspirin. Eight and 15 days later, all the rats received 15 mg/kg AOM. Eleven weeks later, animals that were receiving the control ...
http://oxfordindex.oup.com/view/10.1093/carcin/20.3.425
flaxseed oil Archives - Medicinal Plants Information
The benefits of flaxseed are great in number. For a start of there are lots of good nutrients in each little seed. These include a wide spectrum of vitamins and minerals and lots of really good Omega 3 fats. In fact they have so much Omega 3 that they rival fish as a source of these valuable fats. This is good news if you are a vegan! More good news for vegans is that you can make a very good egg substitute using the gel found in flaxseeds. This gel is also found in the ground meal. It is very easy to use flaxseed meal as an egg substitute. You should also use it if you have an egg allergy.. Another neat thing about flaxseeds is that they contain practically zero amounts of carbohydrate. This is because the stored energy of the seed is in the form of oil. As a result they are great when it comes to producing food to fit in with a low carb diet.. You can use flaxseed meal in the same way that you use flour. This means that it is great for baking. Exchanging part of the flour for flaxseed meal ...
http://medicinalplantsinformation.com/rooibosteaandhealth/flaxseed-oil/
Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in...Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in...
The influence of bovine lactoferrin (bLf) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). In experiment I, 2% and 0.2% bLf, and Bifidobacterium longum (B. longum) as a positive control at 3% were given in the diet for 4 weeks, along with two s.c. 15 mg/kg …
https://pubmed.ncbi.nlm.nih.gov/9781370/?dopt=Abstract
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) - Full Text...Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) - Full Text...
PRIMARY OBJECTIVES:. I. To determine mean percentage change from baseline in prostaglandin E2 (PGE2) within ACF pre and post 30 days of curcumin administration at a specified dose.. SECONDARY OBJECTIVS:. I. To determine mean percentage change from baseline in 5-hydroxy-eicosatetraenoic acid (5-HETE) within ACF pre and post 30 days of curcumin administration at a specified dose.. II. To determine mean percentage change from baseline in PGE2 and 5-HETE within comparison normal mucosa pre and post 30 days of curcumin administration at a specified dose.. III. To quantify corresponding enzyme changes in the cyclooxygenases (COX-1, COX-2,) and lipoxygenase (5-LOX) protein abundance. Semi-quantitative changes in these proteins will be measured by western blotting and correlated with changes in prostaglandins and leukotrienes respectively.. IV. Document changes in total ACF number. V. Determine proliferation by Ki-67 IHC in rectal mucosa pre and post therapy and correlate with changes in ACF number and ...
https://clinicaltrials.gov/ct2/show/NCT00365209
How to Cook Thai Rice Sticks - Worth The WhiskHow to Cook Thai Rice Sticks - Worth The Whisk
Follow This cooking class at Lets Get Cookin in Westlake Village was great fun - presented by prolific cookbook author, Hugh Carpenter, we foodies were immersed in Thai recipes, always good eats. Hughs dry sense of humor kept us in
http://worththewhisk.com/2009/11/17/how-to-cook-thai-rice-sticks/
01.09 Myeloid cells drive early inflammation and orchestrate salivary glands tertiary lymphoid structures formation in a model...01.09 Myeloid cells drive early inflammation and orchestrate salivary glands tertiary lymphoid structures formation in a model...
Background Tertiary lymphoid structures (TLS) are leukocytes aggregates forming in non-lymphoid tissues in response to chronic inflammation. Salivary glands (SG) of patients with Sjögrens syndrome (SS) develop TLS characterised by B/T cell compartmentalization, specialised vasculature (HEV), functional B cell activation and local differentiation of autoreactive plasma cells. Although TLS presence in SS SG associates with an aggressive disease progression, the mechanisms triggering their formation in SS are largely unknown. We recently developed a model of inducible TLS formation, breach of self-tolerance and salivary hypofunction upon delivery of a replication-deficient adenovirus-5 (AdV5) into C57BL/6 mice SG. In this model, 3 weeks after infection, we observed fully formed and functional TLS, breach of self-tolerance and loss of salivary function.. Here we characterised the presence, function and relevance in TLS formation of the myeloid compartment in the first month post-infection. ...
http://ard.bmj.com/content/76/Suppl_1/A4.2
Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane...Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane...
Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, individually and in combination, were tested on azoxymethane induced colon carcinogenesis in Sprague-Dawley rats. The effect was observed on aberrant crypt foci (ACF), the preneoplastic lesion. To investigate the mechanism of action of the agents used, cell proliferation and the level of apoptosis were determined and the expression of cyclooxygenase-2 (COX-2) protein was analyzed in the colon. Following treatment, significant inhibition of the level of cell proliferation (P|0.01 in garlic; P|0.001 in tomato and P|0.001 in combination treatment group with respect to the carcinogen control group), significant induction of apoptosis (P|0.01 in garlic treated; P|0.01 in tomato treated and P|0
https://www.semanticscholar.org/paper/Modulatory-influence-of-garlic-and-tomato-on-cyclo-Sengupta-Ghosh/b708749d3be9285f2b83ae2951232a23e6f83e78
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Introduction: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We performed high-magnification chromoscopic colonoscopy to identify ACF in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACF in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACF were also assessed.. Results: The prevalence of ACF was 64%, 88% and 95%, and the mean number of ACF was 3.6, 6.2 and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. Older age and men had increased prevalence and number of ACF. When ...
http://cancerpreventionresearch.aacrjournals.org/content/4/10_Supplement/A12
Thai imported rice to feed Indonesia
The Indonesian government expects the next delivery of imported rice to arrive by the end of March and help address concerns of a shortage in the food supply, a minister said. Citing traders in multiple countries, it was reported on Wednesday that the State Logistics Agency (Bulog) placed an order of 820,000 tons of imported Thai rice, more than four times higher than the initial order of 170,000 to 200,000 tons. Sutarto Alimoeso, president director of Bulog, declined to confirm the amount. State Enterprises Minister Mustafa Abubakar said Bulog needed to import more rice to plug a hole in domestic supplies. The rice order is a carryover from last year. The next shipment must come before March, because in March we will a big harvest here and that could disturb supply, Sutarto said. Rice is the main staple food for Indonesia. Local farmers have supplied 130 tons of rice this month, Sutarto said, in addition to the supply in Bulogs warehouses. He declined to disclose the current level of stocks, ...
http://www.aseanaffairs.com/indonesia_news/agriculture/thai_imported_rice_to_feed_indonesia
agriculture crops sap reservoir for iran polymer in iran | manufacturer of polyacrylamide for water treatment industrialagriculture crops sap reservoir for iran polymer in iran | manufacturer of polyacrylamide for water treatment industrial
in Thailand represents a significant portion of the Thai economy and labor force.[1] In 2017, the value of all Thai rice traded was 174.5 billion baht, about 12.9% of all farm production.[2] Of the 40% of Thais who work in agriculture, 16 Get Price ...
https://shorelinechurch.co.za/ippd/agriculture-crops-sap-reservoir-for-iran-polymer-in-iran-35/
Central Asian Beef PilafCentral Asian Beef Pilaf
This recipe was given to me by my friend Yulia she grew up in Tajikistan a small land locked mountainous country in Central Asia, it was governed by Russia at that time. She learnt this dish while there it would be made as a big communal dish and shared as a family. Heres a nice little article on the country from a group of travel bloggers who drove across Asia and their views A rallying cry. Its a tasty dish that can be made with vegetables, I did one loaded with veggies and a mixture of red and white Thai rice, beef or chicken, a great one pot meal ...
http://www.chowandchatter.com/2013/09/central-asian-beef-pilaf.html
Calories in Flaxseed Pizza Crust - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipesCalories in Flaxseed Pizza Crust - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Full nutritional breakdown of the calories in Flaxseed Pizza Crust based on the calories and nutrition in each ingredient, including Natures Path Organic FlaxPlus Flaxseed meal, Olive Oil, Egg, fresh, whole, raw, Parmesan Cheese, grated, Baking Powder and the other ingredients in this recipe.
https://recipes.sparkpeople.com/recipe-calories.asp?recipe=1338946
Calories in flax bread - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipesCalories in flax bread - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Full nutritional breakdown of the calories in flax bread based on the calories and nutrition in each ingredient, including Olive Oil, Egg, fresh, whole, raw, Bobs Red Mill Whole Ground Flaxseed Meal, 2 Tbsp., low carb baking mix, Baking Powder and the other ingredients in this recipe.
https://recipes.sparkpeople.com/recipe-calories.asp?recipe=2280481
Crypt::OpenPGP - finding and using preferred SK algorithm
usr/bin/perl -w use Crypt::OpenPGP; use Crypt::OpenPGP::KeyRing; my($keyfile, $email) = @ARGV; my $ring = Crypt::OpenPGP::KeyRing-,new(Filename =, $keyfile); my $pgp = Crypt::OpenPGP-,new(PubRing =, $ring); my $kb = $ring-,find_keyblock_by_uid($email); my $alg = $kb-,preferred_sk_alg; my $crypt = $pgp-,encrypt( Data =, squeamish ossifrage, Recipients =, [ $email ], Armour =, 1, ($alg ? (Cipher =, $alg) : ()), # use default if no preference loc +ated ); print $crypt; exit 0; { package Crypt::OpenPGP::KeyBlock; sub preferred_sk_alg { my $self = shift; use Crypt::OpenPGP::Cipher; my $supported = Crypt::OpenPGP::Cipher-,supported; my @prefs; for my $sig (@{ $self-,get(Crypt::OpenPGP::Signature) }) { if ($sig-,is_primary) { unshift @prefs, @{ $sig-,preferred_sk_alg }; } else { push @prefs, @{ $sig-,preferred_sk_alg }; } } for (@prefs) { return $_ if $supported-,{$_}; } return; } } { package Crypt::OpenPGP::Signature; sub is_primary { my $self = shift; my $packet = $self-,find_subpacket(25); # ...
http://www.perlmonks.org/?node_id=326235
Choosing Between Plywood, Hardboard, MDF and Particleboard for Your Projects / Rockler How-toChoosing Between Plywood, Hardboard, MDF and Particleboard for Your Projects / Rockler How-to
All sheet goods are not created equal, if your next project calls for these versatile materials, Bill Hylton has some suggestions on what to buy.
http://www.rockler.com/how-to/choosing-plywood-hardboard-mdf-particleboard-projects/
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.* - Propolis Science
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.. Shimizu K, Das SK, Baba M, Matsuura Y, Kanazawa K.. Source. Department of Life Science, Graduate School of Science and Technology, Kobe University, Rokkodai, Nada-ku, Kobe 657-8501, Japan.. Abstract. Artepillin C, a prenylated phenylpropanoid found specifically in Brazilian propolis, has been shown to be a bioavailable antioxidant. In this study, artepillin C was tested for colon cancer-preventing activity using azoxymethane-challenged ddY mice. Oral doses of 80 and 160 mg/kg body weight of propolis or 10mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively. In liver of the mice, glutathione S-transferase and NADPH:quinone reductase activity increased with the doses of propolis or artepillin C, and an antioxidant-responsive element (ARE) was found to be activated for binding ...
http://www.propolisscience.org/propolis-compounds/artepillin-c-research/dietary-artepillin-c-suppresses-the-formation-of-aberrant-crypt-foci-induced-by-azoxymethane-in-mouse-colon/
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise | GutA novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise | Gut
Results A single bout of exercise increased the expression and secretion of SPARC in skeletal muscle in both mice and humans. In addition, in an azoxymethane-induced colon cancer mouse model, regular low-intensity exercise significantly reduced the formation of aberrant crypt foci in wild-type mice but not in SPARC-null mice. Furthermore, regular exercise enhanced apoptosis in colon mucosal cells and increased the cleaved forms of caspase-3 and caspase-8 in wild-type mice but not in SPARC-null mice. Culture experiments showed that SPARC secretion from myocytes was induced by cyclic stretch and inhibited proliferation with apoptotic effect of colon cancer cells.. ...
http://gut.bmj.com/content/early/2012/11/15/gutjnl-2011-300776
Banana Chocolate Chip Oat Flaxseed Almond Muffins RecipeBanana Chocolate Chip Oat Flaxseed Almond Muffins Recipe
I love cooking for other people, especially folks who are going through a rough patch and need a little help with meals. One of my friends that Ive been cooking for over the past year is so sweet. Whenever she returns the empty containers from the food Ive made, she thoughtfully tucks in a thank you note, a favorite recipe, some spices from my favorite spice store, or ingredients that she thinks I will get better use out of than she can. One of the ingredients shes given me a few packs of is flaxseed meal (ground up flaxseed). Flaxseeds are a wonderful source of fiber and heart healthy omega-3 essential fatty acids.. Ive sprinkled whole flaxseeds on yogurt and used flaxseed meal as a substitute for eggs in recipes, but did you know it can also be used to substitute for oil in baked recipes?. ...
https://jeanetteshealthyliving.com/banana-chocolate-chip-oat-flaxseed-almond-muffins/?replytocom=1032932
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4975 Colon cancer is one of the major causes of cancer mortality in the United States of America. Early detection and prevention are the important alternative approaches to control colon cancer. Recently, substantial attention has been focused on identifying naturally occurring chemopreventive compounds capable of inhibiting early events involved in malignant transformation. Of late, laboratory studies have demonstrated that silibinin exhibits various biological activities and significantly inhibits tumorigenesis at various organ sites in several rodent models. The present study is an attempt to investigate the dose-dependent effect of dietary silibinin on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation in Fisher 344 male rats. In addition, we analyzed the effect of silibinin on cell proliferation and the induction of apoptosis by immunohistochemical staining during AOM-induced ACF formation. Five-week-old male F344 rats were randomly divided into 12 groups and fed AIN-76A control ...
http://cancerres.aacrjournals.org/content/67/9_Supplement/4975
Plus itPlus it
Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We carried out high-magnification chromoscopic colonoscopy to identify ACFs in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACFs in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACFs were also assessed.. Results: The prevalence of ACF was 64%, 88%, and 95%, and the mean number of ACF was 3.6, 6.2, and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. When differences in the prevalence and number of ACFs among age- ...
http://cebp.aacrjournals.org/content/early/2011/08/05/1055-9965.EPI-11-0104
What world price?What world price?
There is no consensus on what defines a reference for the world rice price. A review on rice as a differentiated commodity shed two important insights. First, it confirms that few studies have considered segmentation of rice in their price analysis. Second, Thai 5% brokens has often been considered the world reference price for rice but no empirical exercise has been carried out to validate this. This study analyzes the extent of market integration in the international rice market by generating empirical evidence on the cointegration of different export prices. We start our analysis with the assumption that rice is not a homogeneous good. In this context, we establish clusters by rice quality and determine which export markets best represent the world rice price within and across clusters. The study uses 19 monthly average export rice price quotations from January 2000 to July 2012 extracted from the FAO Global Information and Early Warning System food price database and from the Thai Rice Exporters
https://ageconsearch.umn.edu/record/142241
Rice FlourRice Flour
Double Bear brands rice flour is produced from high quality and selected species of Thai rice. It is sorted fromthe best rice growing regions and carefully stored and managed in accordance with international standards. Modern production process together with the knowhow that we have accumulated for over 35 years result in the best quality rice flour which meets a wide range of customers needs.. ...
http://www.burapaprosper.com/product/1/1
LACTATION COOKIES recipe | Epicurious.comLACTATION COOKIES recipe | Epicurious.com
Preheat oven at 375. Mix 2 T of flaxseed meal and water, set aside 3-5 minutes. Cream butter and sugar. Add eggs. Stir flaxseed mix into butter mix and add vanilla. Beat until well blended. Sift: dry ingredients, except oats and choc chips. Add butter mix to dry ing. Stir in the oats and then the choc chips. Drop on parchmant paper on baking sheet. Bake 8-12 minutes ...
https://www.epicurious.com/recipes/member/views/LACTATION-COOKIES-1252680
Flax Seeds for Weight Loss: Benefits and How to Use ThemFlax Seeds for Weight Loss: Benefits and How to Use Them
Flax seed is helpful for weight loss. Flax is grown for getting its seeds, which can be included in flaxseed meal that are pressed into the oil or produced into linen.
https://www.dailyfitnesstips4u.com/flax-seeds-for-weight-loss.html
Hot Cereal Time of YearHot Cereal Time of Year
Now I have traded oats for flaxseed meal and chia. Have you tried chia cereal? I reviewed chia seeds last fall (that post is HERE) and I really have enjoyed having them in my diet BUT recently found what I like even better -- Milled Chia -- the texture is much more *cereal*-like and not so seedy to me. ...
http://faithfulnessfarm.blogspot.com/2013/09/hot-cereal-time-of-year.html
LOW CARB BROCCOLI AND CHEESE FRITTERS - The Nature Miracle
2. Mix together the cheese, almond flour, flaxseed meal and baking powder with the broccoli. If you want to add any extra seasonings (salt and pepper), do it at this point ...
https://thenaturemiracle.com/low-carb-broccoli-and-cheese-fritters/
File php7-crypt-tests.patch of Package php72 - Open Build ServiceFile php7-crypt-tests.patch of Package php72 - Open Build Service
Index: php-7.2.12/ext/standard/config.m4 =================================================================== --- php-7.2.12.orig/ext/standard/config.m4 2018-11-06 11:48:33.000000000 +0100 +++ php-7.2.12/ext/standard/config.m4 2018-11-09 16:35:10.505160977 +0100 @@ -242,7 +242,7 @@ int main() { dnl dnl If one of them is missing, use our own implementation, portable code is then possible dnl -if test $ac_cv_crypt_blowfish = no ,, test $ac_cv_crypt_des = no ,, test $ac_cv_crypt_ext_des = no ,, test $ac_cv_crypt_md5 = no ,, test $ac_cv_crypt_sha512 = no ,, test $ac_cv_crypt_sha256 = no ,, test x$php_crypt_r = x0; then +if test $ac_cv_crypt_blowfish = no ,, test $ac_cv_crypt_des = no ,, test $ac_cv_crypt_md5 = no ,, test $ac_cv_crypt_sha512 = no ,, test $ac_cv_crypt_sha256 = no ,, test x$ac_cv_lib_crypt_crypt_r = x0; then dnl dnl Check for __alignof__ support in the ...
http://obs.intercom.it/package/view_file/home:rottame:vhosts-ng/php72/php7-crypt-tests.patch?expand=0
Pembroke MDFPembroke MDF
Pembroke MDF has hired BM Metals Mechanical group to come to site and perform maintenance to different pieces of equipment. When Pembroke calls, they inform me of the job and how many millwrights their looking for. Jobs in Pembroke usually go for 3 t
https://www.milman.ca/companies/bm-metals/projects/listing/3/Pembroke-MDF/
Muntinlupa Development Foundation (MDF)Muntinlupa Development Foundation (MDF)
Muntinlupa Development Foundation (MDF) is a non-stock, non-profit organization founded by Muntinlupa residents to uplift the conditions of its communities.
https://www.muntinlupafoundation.org.ph/news-single.php?id=25
ORPHAN BLACK - SEASON 2 - CULTURE CRYPTORPHAN BLACK - SEASON 2 - CULTURE CRYPT
Culture Crypt presents the complete and definitive episode guide for Orphan Black, including a summary, synopsis, recap, and review of every episode from Season Two. Orphan Black premiered on BBC America in March of 2013, and stars Tatiana Maslany.
http://culturecrypt.com/orphan-black/season-2
Aberrant crypt fociAberrant crypt foci
... (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci ... When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent. The resulting figure is ... Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice. Takayama T, ... Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: ...
https://en.wikipedia.org/wiki/Aberrant_crypt_foci
PiceidPiceid
Resveratrol glucoside from transgenic alfalfa prevents aberrant crypt foci in mice. Resveratroloside (3,5,4'-trihydroxystilbene ... "Resveratrol from Transgenic Alfalfa for Prevention of Aberrant Crypt Foci in Mice". Nutrition and Cancer. 62 (3): 351-361. doi: ...
https://en.wikipedia.org/wiki/Piceid
KRASKRAS
Pretlow TP, Pretlow TG (November 2005). "Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer?". ...
https://en.wikipedia.org/wiki/KRAS
OrlistatOrlistat
"Aberrant crypt foci of the colon as precursors of adenoma and cancer". N Engl J Med. 339 (18): 1277-84. doi:10.1056/ ... 2-dimethylhydrazine produced significantly higher numbers of aberrant crypt foci (ACF) colon lesions than did the carcinogen ...
https://en.wikipedia.org/wiki/Orlistat
CookingCooking
July 1992). "Promotion of aberrant crypt foci and cancer in rat colon by thermolyzed protein". J. Natl. Cancer Inst. 84 (13): ...
https://en.wikipedia.org/wiki/Cooking
Stem cell markerStem cell marker
June 2005). "Metallothionein crypt-restricted immunopositivity indices (MTCRII) correlate with aberrant crypt foci (ACF) in ... crypt-restricted immunopositivity indices (MTCRII) monosomy 7 Mouse orthologue of ARX MRP4 Msi-1 Musashi Musashi-1 Mutant BCRP ...
https://en.wikipedia.org/wiki/Stem_cell_marker
HPG80HPG80
"Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM". American Journal ... "Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts ...
https://en.wikipedia.org/wiki/HPG80
MicrocystinMicrocystin
... in drinking water enhance the growth of aberrant crypt foci in the mouse colon". Journal of Toxicology and Environmental Health ...
https://en.wikipedia.org/wiki/Microcystin
Sodium-coupled monocarboxylate transporter 1Sodium-coupled monocarboxylate transporter 1
... is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A. ... 2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary ...
https://en.wikipedia.org/wiki/Sodium-coupled_monocarboxylate_transporter_1
ACFACF
... human gene Aberrant crypt foci, a preneoplastic lesion on the mucosa of colon or rectum Antecubital fossa, part of the ...
https://en.wikipedia.org/wiki/ACF
TACSTD2TACSTD2
Aberrant overexpression of Trop-2 has been described in several solid cancers, such as colorectal, renal, lung, and breast ... and tonsillar crypts. Trop-2 plays a role in tumor progression by actively interacting with several key molecular signaling ... A focused review on Trop-2-based antibody-drug conjugates and their predictive biomarkers". Bosnian Journal of Basic Medical ...
https://en.wikipedia.org/wiki/TACSTD2
Field cancerizationField cancerization
Almost every crypt in all tissue samples from this patient showed high expression of KU86. However, the majority of crypts in ... Field defects associated with gastrointestinal tract cancers also commonly displayed reduced apoptosis competence, aberrant ... These initial molecular changes may subsequently progress to cytologically recognizable premalignant foci of dysplasia, and ... The crypts with reduced or absent expression of ERCC1 or PMS2 usually occurred in large patches of adjacent crypts. Both ERCC1 ...
https://en.wikipedia.org/wiki/Field_cancerization
DNMT1DNMT1
Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. DNA methyltransferase ... "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". ... crypt expansion and altered differentiation timing of ISCs, and proliferation and maintenance of MaSCs. GRCh38: Ensembl release ... to form a complex at replication foci". Nature Genetics. 25 (3): 269-77. doi:10.1038/77023. PMID 10888872. S2CID 26149386. Kim ...
https://en.wikipedia.org/wiki/DNMT1
Colorectal cancerColorectal cancer
Abnormal (aberrant) methylation occurs as a normal consequence of normal aging and the risk of colorectal cancer increases as a ... The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell. The most commonly ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ...
https://en.wikipedia.org/wiki/Colorectal_cancer
The MonkThe Monk
John Moore's Zeluco focuses on the nefarious plots of a single man who cannot control his passions. Like Ambrosio, Zeluco's ... In the confusion, Lorenzo finds a group of nuns and a young woman named Virginia hiding in the crypt. Lorenzo discovers a ... In England, the sexual demonization the aberrant Catholic "Other" was part and parcel of the ideological formation of the ... He takes Antonia to the crypt beneath the convent, where, she awakens from her drugged sleep and Ambrosio rapes her. Afterward ...
https://en.wikipedia.org/wiki/The_Monk
Albinism in popular cultureAlbinism in popular culture
In 2009, two African American albinistic fashion models, Shaun Ross and Diandra Forrest, were the focus of an episode of the ... ISBN 978-0-7607-3979-2. "Tales From the Urban Crypt". New York Daily News Online. Archived from the original on 15 May 2008. ... aberrant even before his experimentation, he subsequently became completely deranged. Albino bias is also alleged in modern ... and his albinism is not the central focus of his character. (While his name, or lack thereof, seems to indicate otherwise, all ...
https://en.wikipedia.org/wiki/Albinism_in_popular_culture
Somatic evolution in cancerSomatic evolution in cancer
Studies of this issue have focused mainly at the gene mutation level, as copy number variation, LOH and specific chromosomal ... leading to the accumulation of aberrant cells. Most mammalian cells can replicate a limited number of times due to progressive ... predispose to clonal expansions that encompass large numbers of crypts in some conditions such as Barrett's esophagus. He also ... Many of the somatic evolutionary studies have traditionally been focused on clonal expansion, as recurrent types of changes can ...
https://en.wikipedia.org/wiki/Somatic_evolution_in_cancer
Ramsey CampbellRamsey Campbell
His later work continued the focus on Liverpool; in particular, his 2005 novel Secret Stories (published in the U.S. in an ... This collection of juvenilia was published thirty years later, as a special issue of Crypt of Cthulhu magazine titled Ghostly ... as is common in Campbell's work involving aberrant mental states, it is not entirely apparent that these events have a ... Another issue of this magazine Crypt of Cthulhu No 43 (Hallowmas 1983), titled The Tomb-Herd and Others collects various early ...
https://en.wikipedia.org/wiki/Ramsey_Campbell
Freud and PhilosophyFreud and Philosophy
ISBN 0-262-54057-6. Dufresne, Todd (2000). Tales From the Freudian Crypt: The Death Drive in Text and Context. Stanford, ... ISBN 0-333-48638-2. Genosko, Gary (2002). Félix Guattari: An Aberrant Introduction. London: Continuum. ISBN 0-8264-6034-8. ... who nevertheless found its approach to interpretation limited by its focus on the ideas of symbol and double meaning, Richard ...
https://en.wikipedia.org/wiki/Freud_and_Philosophy
CarcinogenesisCarcinogenesis
Loss of that methylation can induce the aberrant expression of oncogenes, leading to cancer pathogenesis. Known mechanisms of ... or on discrete neoplastic foci in vitro. Yet there is evidence that more than 80% of the somatic mutations found in mutator ... natural selection of a mutant or epigenetically altered cell among the stem cells at the base of one of the intestinal crypts ... "Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment". Cytokine & Growth Factor Reviews. ...
https://en.wikipedia.org/wiki/Carcinogenesis
Stem-cell nicheStem-cell niche
March 2014). "Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging". Nature. 507 (7492): 362 ... Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between ... Gout S, Huot J (December 2008). "Role of cancer microenvironment in metastasis: focus on colon cancer". Cancer Microenvironment ... In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the ...
https://en.wikipedia.org/wiki/Stem-cell_niche
Induced stem cellsInduced stem cells
However, some genetically normal iPSCs failed to produce all-iPSC mice because of aberrant epigenetic silencing of the ... March 2014). "De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts". Cell Reports. 6 (6): 1046- ... January 2013). "Microenvironment-evoked cell lineage conversion: Shifting the focus from internal reprogramming to external ...
https://en.wikipedia.org/wiki/Induced_stem_cells
Abstract 3240: Proximal human aberrant crypt foci as surrogate markers of colorectal cancer risk | Citedby Results | Cancer...Abstract 3240: Proximal human aberrant crypt foci as surrogate markers of colorectal cancer risk | Citedby Results | Cancer...
Abstract 3240: Proximal human aberrant crypt foci as surrogate markers of colorectal cancer risk. Cancer Res (2014) 74 (19_ ...
https://aacrjournals.org/cancerres/crossref-citedby/595225
The efficacy of a leukotriene receptor antagonist in the treatment of human rectal aberrant crypt foci: a nonrandomized, open...The efficacy of a leukotriene receptor antagonist in the treatment of human rectal aberrant crypt foci: a nonrandomized, open...
Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and darker in methylene blue ... staining than normal crypts, are regarded to be a fine surrogate biomarker of CRC. Therefore, this prospective study was ... Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and darker in methylene blue ... Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and darker in methylene blue ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07266-6
A Multicenter Study of Prevalence and Risk Factors for Aberrant Crypt Foci<...A Multicenter Study of Prevalence and Risk Factors for Aberrant Crypt Foci<...
A Multicenter Study of Prevalence and Risk Factors for Aberrant Crypt Foci. / Mutch, Matthew G.; Schoen, Robert E.; Fleshman, ... Background & Aims: Aberrant crypt foci (ACF) are the putative precursor of colorectal adenomas. However, there are limited data ... N2 - Background & Aims: Aberrant crypt foci (ACF) are the putative precursor of colorectal adenomas. However, there are limited ... AB - Background & Aims: Aberrant crypt foci (ACF) are the putative precursor of colorectal adenomas. However, there are limited ...
https://profiles.wustl.edu/en/publications/a-multicenter-study-of-prevalence-and-risk-factors-for-aberrant-c
IMSEAR at SEARO: Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2...
Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS ... Sengupta A, Ghosh S, Bhattacharjee S. Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in ... Following treatment, significant reduction in the incidences of aberrant crypt foci (p,0.05) was observed. This reduction in ... induced colonic aberrant crypt foci (ACF) in Swiss Albino mice. The secondary aim, was to explore the ability of cardamom to ...
https://imsear.searo.who.int/handle/123456789/37400
Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the...Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the...
Aberrant foci; apoptosis; colon cancer; crypt; dimethylhydrazine; flavanone; karanjin; p53/Bcl2/BAX pathway; rats ... Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the ... Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci a ... histopathological assessment including number of aberrant crypt foci (ACF); immunohistochemical staining for Bcl-2-associated X ...
https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-32580584
Nutrients | Free Full-Text | Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract PolyphenolsNutrients | Free Full-Text | Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
DMH induced aberrant crypt foci, number of polyps, reversed the markers of oxidative stress, antioxidant status, CYP450 content ... DMH induced aberrant crypt foci ↓ DMH induced increase in bacterial enzymes. [110]. ... showed a decrease in development of DMH-induced aberrant crypt foci by decreasing DMH-induced elevation of bacterial enzymes [ ... GST positive foci. [44]. Swiss mice exposed to γ-IR (liver). 6Gy γ-IR (once) followed by 1000 mg/kg/day RE orally (5 days). ...
https://www.mdpi.com/2072-6643/8/11/731/htm
Colonic Polyps Clinical Presentation: History, Physical ExaminationColonic Polyps Clinical Presentation: History, Physical Examination
BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am J Pathol. 2005 Apr. 166(4):1069-75. [QxMD MEDLINE Link]. ...
https://emedicine.medscape.com/article/172674-clinical
Centro Internacional de Matemática - CIMCentro Internacional de Matemática - CIM
Aberrant Crypt Foci and Human Colorectal Polyps: mathematical modelling and endoscopic image processing. Extracted from the FCT ...
https://www.cim.pt/magazines/search?mag_term1=Peter%20Gothen&options_1=author
Hypothalamic beta-endorphin neurons suppress preneoplastic and neoplastic lesions development in 1,2-dimethylhydrazine induced...Hypothalamic beta-endorphin neurons suppress preneoplastic and neoplastic lesions development in 1,2-dimethylhydrazine induced...
Preparation for aberrant crypt foci counting. The colon was processed as follows for the determination of aberrant crypt foci ( ... One to three crypts), medium (four to six crypts) or large (more than six crypts) by the number of crypts per foci. The total ... Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 1995;93:55-71 ... Aberrant crypt foci as microscopic precursors of colorectal cancer. World J Gastroenterol. 2003;9:2642-9 ...
https://jcancer.org/v08p3105.htm
Registration Dossier - ECHARegistration Dossier - ECHA
Aberrant crypt foci To examine the impact of E171 on initiation of ACF´s rats were exposed to E171 for 100 days. When the ... Aberrant crypt foci after 100 days. After induction with DMH E171 treatment at 10 mg/kg of bw/day significantly increased the ... Aberrant crypt foci (ACF) were first discovered in mice in 1987 (Bird, 1987) and in colonic mucosa of humans suffering from ... The E171-treatment (with DMH pre-treatment) at 10 mg/kg bw/day led to an increase in aberrant crypt foci in the colon of ...
https://echa.europa.eu/bg/registration-dossier/-/registered-dossier/15560/7/7/3
Prebiotics and ProbioticsPrebiotics and Probiotics
Reduction of aberrant crypt foci by ingestion of polydextrose in the rat colorectum. Nutrition Research 23, 117-122. Jackson K ...
https://caloriecontrol.org/prebiotics-and-probiotics/
Introducing inulin-type fructans | British Journal of Nutrition | Cambridge CoreIntroducing inulin-type fructans | British Journal of Nutrition | Cambridge Core
Reddy, BS, Hamid, R & Rao, CV (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci ... and long-chained fructans on large intestinal physiology and carcinogen-induced aberrant crypt foci in rats. Nutr Cancer 42, ... They also induce changes in colonic epithelium stimulating proliferation in the crypts, increasing the concentration ...
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/introducing-inulintype-fructans/72F536DAEAC3BCBE7D0AF40A2AC97242
Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated ratsCruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats
Groups fed lyophilized vegetables did not differ in aberrant crypt foci (ACF), sialomucin-producing foci, or mucin-depleted ... These results do not support changes in hepatic carcinogen metabolism or colonic crypt cytokinetics as a mechanism. ... foci (MDF) numbers. However, all fresh vegetable diets significantly decreased ACF (approximately 40%) and MDF numbers. ...
https://pubmed.ncbi.nlm.nih.gov/18287361/
WikiGenes - artepillin - (E)-3-[4-hydroxy-3,5-bis(3-methylbut-2...WikiGenes - artepillin - (E)-3-[4-hydroxy-3,5-bis(3-methylbut-2...
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon. Shimizu, K., Das, ... reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively [4]. ...
https://www.wikigenes.org/e/chem/e/5472440.html
De novo assembly and comparative transcriptome analysis of Euglena gracilis in response to anaerobic conditions | BMC Genomics ...De novo assembly and comparative transcriptome analysis of Euglena gracilis in response to anaerobic conditions | BMC Genomics ...
Antitumor activity of the β-glucan paramylon from Euglena against preneoplastic colonic aberrant crypt foci in mice. Food Funct ... Markou G, Nerantzis E. Microalgae for high-value compounds and biofuels production: a review with focus on cultivation under ... Consequently, our literature search focused heavily on genes that may participate in paramylon and wax ester metabolism. ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2540-6
21st International Conference on Emerging Infectious Diseases in the Pacific Rim - Volume 25, Number 11-November 2019 -...
... fiber fermentation by lactic acid bacteria accelerates colonic epithelial cell turnover and development of aberrant crypt foci ... The 21st conference, hosted by the Ministry of Health of Vietnam and held in Hanoi during February 26-March 1, 2019, focused on ... The session on AMR focused on drug resistance in different community settings, microbial mechanisms to mediate AMR, and ...
https://wwwnc.cdc.gov/eid/article/25/11/19-1184
Report a CitationReport a Citation
... of Antioxidant Contents in Red Sorrel and its nticarcinogenic Potential in Azoxymethane-Induced Colonic Aberrant Crypt Foci ...
https://scialert.net/fulltext/reportcitation.php?doi=rjphyto.2008.69.76
Bifidobacteria: Uses, Side Effects, Dose, Health Benefits, Precautions & WarningsBifidobacteria: Uses, Side Effects, Dose, Health Benefits, Precautions & Warnings
Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal ... Bifidobacterium longum and lactulose suppress azoxymethane-induced colonic aberrant crypt foci in rats. Carcinogenesis 1997;18( ...
https://www.emedicinehealth.com/bifidobacteria/vitamins-supplements.htm
Identification of aspirin analogues that repress NF-κB signalling and demonstrate anti-proliferative activity towards...Identification of aspirin analogues that repress NF-κB signalling and demonstrate anti-proliferative activity towards...
Liu Y, Ju J, Xiao H, et al: Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation ... or aberrant crypt foci) (7-11). Recent meta-analysis of a large number of patient studies indicates that treatment with daily ... we focused our attention on the anti-proliferative activity of DiA and F-DiA in more detail in vitro and in vivo. ... a significant focus of research has understandably been into the development of agents that can reduce specific COX activity ( ...
https://www.spandidos-publications.com/10.3892/or.2014.3373
Annatto: Health Benefits, Side Effects, Uses, Dose & PrecautionsAnnatto: Health Benefits, Side Effects, Uses, Dose & Precautions
Agner, A. R., Bazo, A. P., Ribeiro, L. R., and Salvadori, D. M. DNA damage and aberrant crypt foci as putative biomarkers to ...
https://www.rxlist.com/annatto/supplements.htm
Distinct Effects of Carrageenan and High-Fat Consumption on the Mechanisms of Insulin Resistance in Nonobese and Obese Models...Distinct Effects of Carrageenan and High-Fat Consumption on the Mechanisms of Insulin Resistance in Nonobese and Obese Models...
S. Taché, G. Peiffer, A.-S. Millet, and D. E. Corpet, "Carrageenan gel and aberrant crypt foci in the colon of conventional and ...
https://www.hindawi.com/journals/jdr/2019/9582714/
Diabetes drug may protect against cancer | Pharma Strategy Blog
Rectal aberrant crypt foci (ACF) are an endoscopic surrogate marker of colorectal cancer, essentially an early precursor to ... Hosono et al., published an article, Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial after ...
https://pharmastrategyblog.com/2010/09/diabetes-drug-may-protect-against-cancer.html/
Search Results - NaturalNews.comSearch Results - NaturalNews.com
those that contribute to it - More news on aberrant crypt foci Polyphenols in plum exhibit anticancer ... ...
https://naturalnews.com/search.asp?query=anticancer+foods
Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L. casei LBC80R...Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L. casei LBC80R...
Aberrant crypt foci (ACF) in the colon were determined using a microscope. Detoxifying enzymes like quinone reductase (QR) and ... probiotic bacteria; anticancer; colorectal cancer; fermented milk; aberrant crypt foci. Centre:. Centre INRS-Institut Armand ... The rats fed with the three highest doses significantly lowered aberrant crypt (AC) count, while those supplemented with 1.5 ...
https://espace.inrs.ca/id/eprint/3176/
The Lemongrass Health Benefits Most of Us Are Missing Out OnThe Lemongrass Health Benefits Most of Us Are Missing Out On
... on formation of azoxymethane-induced DNA adducts and aberrant crypt foci in the rat colon. Carcinogenesis 18:9449-955, 1997. ...
https://bodyecology.com/articles/lemongrass-php/
Rian Hasson Charles | CTSNetRian Hasson Charles | CTSNet
I was involved in translational projects and investigated the role of aberrant crypt foci (ACF) as a surrogate endpoint ...
https://www.ctsnet.org/home/hasson5
Medicine ExpertGlossary
Cite Definition for aberrant crypt foci. American Psychological Association (APA). aberrant crypt foci. (n.d.). Dictionary of ... www.expertglossary.com/definition/aberrant-crypt-foci.. Chicago Manual of Style (CMS). aberrant crypt foci. www.cancer.gov. ... Browse Related Terms: aberrant crypt foci, ACF, Appendix, cecum, colitis, colon, colon crypt, colon polyp, diverticulosis, ... Aberrant crypt foci form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may ...
https://www.expertglossary.com/medicine/definitions/3
QualityCounts.com Newsletter of 6/20/12QualityCounts.com Newsletter of 6/20/12
Resveratrol also tended to reduce aberrant crypt foci development and decrease circulating interleukin 6 and insulin ...
https://qualitycounts.com/newsletter12/120620.htm
Lükopeen - VikipeediaLükopeen - Vikipeedia
... on colonic aberrant crypt foci formation in rats. - Cancer Lett, 1996, kd 107, nr 1, lk 137-142. Resümee. Resümee. ...
https://et.wikipedia.org/wiki/L%C3%BCkopeen
Colorectal cancerAzoxymethane-induced aberrant crypt fociColonic aberrant cryptSurrogateProliferationMethylene bluePutativeLesionsClustersRatsHyperplasiaEpitheliumChemopreventiveCancerEffectsLargeCellsNumbersArticleProfileAdenomasColorectalColonsPreneoplastic lesionsPutative preneoplasticEpithelial cellsColonic cryptsCarcinogenesisAzoxymethaneDouble-blindedMiceMucosaOccurrenceDysplasiaSignificantlyInflammatoryTumorFormationNutritionRelevanceCancersTissuesAimsCancerGene ExpressionMutantLiverTreatmentArticleStudyOccursCellAnalysisReview
Colorectal cancer2
  • Rectal aberrant crypt foci (ACF) are an endoscopic surrogate marker of colorectal cancer, essentially an early precursor to malignant disease. (pharmastrategyblog.com)
  • In addition to building upon my repertoire of basic science techniques, I was involved in translational projects and investigated the role of aberrant crypt foci (ACF) as a surrogate endpoint biomarker in colorectal cancer chemoprevention. (ctsnet.org)
Azoxymethane-induced aberrant crypt foci1
  • IMSEAR at SEARO: Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. (who.int)
Colonic aberrant crypt1
  • cardamom against azoxymethane (AOM) induced colonic aberrant crypt foci (ACF) in Swiss Albino mice. (who.int)
Surrogate1
  • Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and darker in methylene blue staining than normal crypts, are regarded to be a fine surrogate biomarker of CRC. (biomedcentral.com)
Proliferation1
  • They also induce changes in colonic epithelium stimulating proliferation in the crypts, increasing the concentration ofpolyamines, changing the profile of mucins, and modulating endocrine as well as immune functions. (cambridge.org)
Methylene blue1
  • Colorectal aberrant crypt foci (ACF) were analyzed by methylene blue staining. (breakawaymatcha.com)
Putative2
  • Background & Aims: Aberrant crypt foci (ACF) are the putative precursor of colorectal adenomas. (wustl.edu)
  • Agner, A. R., Bazo, A. P., Ribeiro, L. R., and Salvadori, D. M. DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. (rxlist.com)
Lesions1
  • Histopathologies of colon tissues revealed that BEP neurons transplanted animals had lesser tissue lesions such as aberrant crypt foci (ACF) and adenocarcinoma development in the colon than those in control groups. (jcancer.org)
Clusters1
  • Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. (bvsalud.org)
Rats2
  • The rats fed with the three highest doses significantly lowered aberrant crypt (AC) count, while those supplemented with 1.5 and 2 ml FM lowered significantly ACF count compared to group 2 (p ≤ 0.05). (inrs.ca)
  • In one study, pomegranate juice helped reduce aberrant cryptic foci in rats. (goldendayshealth.com)
Hyperplasia1
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
Epithelium1
  • In addition, adhesion molecules mediate migration of the extravasated immune cells through the stroma to the source of maximal chemokine production, as well as through the epithelium to the lumen, where they produce crypt abscesses. (medscape.com)
Chemopreventive1
  • Recently, considerable attention has been focused on identifying naturally occurring chemopreventive compounds capable of inhibiting, retarding, or reversing the multi-step carcinogenesis. (who.int)
Cancer2
  • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. (crossref.org)
  • Smiraglia, D.J. & Plass, C. The study of aberrant methylation in cancer via restriction landmark genomic scanning. (crossref.org)
Effects1
  • Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. (bvsalud.org)
Large1
Cells3
  • Aberrant crypt foci occur during the early stage of dysplasia (abnormal cells in tissues or organs). (fullformslist.com)
  • Adhesion molecules such as intercellular cell adhesion molecule 1 (ICAM1) are necessary for circulating cells to be able to stick to the activated endothelium, which is the first step in the extravasation of mononuclear cells and polymorphonuclear cells into the inflammatory focus. (medscape.com)
  • Proinflammatory molecules are preferentially produced by monocytes and polymorphonuclear cells that have migrated to the inflammatory focus, rather than by resident macrophages. (medscape.com)
Numbers1
  • Groups fed lyophilized vegetables did not differ in aberrant crypt foci (ACF), sialomucin-producing foci, or mucin-depleted foci (MDF) numbers. (nih.gov)
Article1
  • published an article, 'Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial' after their earlier work in rodents. (pharmastrategyblog.com)
Profile1
  • Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. (crossref.org)
Adenomas5
  • ACF, which appear as isolated, grouped or raised crypts of increased size with slit-like or dilated openings, are hypothesized to be structural lesions that can serve as biomarkers for, or possibly as precursor lesions to, colorectal adenomas and cancers. (medscape.com)
  • Aberrant crypt foci (ACF) are putative precursors of colorectal adenomas and have been postulated as a potential biomarker for colorectal cancer. (nih.gov)
  • 1. Efficacy of Difluoromethylornithine and Aspirin for Treatment of Adenomas and Aberrant Crypt Foci in Patients with Prior Advanced Colorectal Neoplasms. (nih.gov)
  • For example, both types of malignancy progress through a sequence of aberrant crypt foci, polyps, adenomas, and carcinomas. (rawveronica.com)
  • Numerous studies have demonstrated that the majority of early neoplastic lesions in the colon (namely, aberrant crypt foci, adenomas, and serrated polyps) lose genomic and/or epigenomic stability, which is likely a critical molecular and pathophysiological event in the initiation and formation of colorectal cancer. (bosterbio.com)
Colorectal12
  • 6. Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps. (nih.gov)
  • 7. Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial. (nih.gov)
  • 10. Number of aberrant crypt foci in the rectum is a useful surrogate marker of colorectal adenoma recurrence. (nih.gov)
  • 13. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. (nih.gov)
  • 14. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. (nih.gov)
  • Because oral curcumin seems preferentially distributed into colorectal mucosa (normal and malignant) compared with its distribution in other organs such as the liver ( 17 ), much clinical testing of curcumin has naturally focused on colorectal diseases, most notably colorectal cancer. (aacrjournals.org)
  • It's very most likely that crypt stem cells signify the cells-of-origin for cancers development, in both spontaneous colorectal and colitis-associated cancers [20]. (rawveronica.com)
  • A limited number of human studies have shown that consumption of berries can prevent colorectal cancer, especially in patients at high risk (familial adenopolyposis or aberrant crypt foci, and inflammatory bowel diseases). (uneatlantico.es)
  • Hence, aberrant DNA methylation occurs in AOM tumors, however the regularity of aberrantly methylated genes is apparently much less common than in individual colorectal cancers. (cylch.org)
  • Although aberrant DNA methylation provides been proven that occurs typically in colorectal cancers lately, the causal function of the epigenetic changes along the way of cancers initiation and advertising is normally poorly understood at the moment. (cylch.org)
  • A well-established mouse style of colorectal cancers that has the to provide understanding into the function of aberrant DNA methylation in the molecular pathogenesis from the polypcancer development sequence may be the azoxymethane (AOM) rodent cancer of the colon model. (cylch.org)
  • The focus of this review is to summarize the functions of APC and MMR gene products in the development of colorectal cancers. (biomedcentral.com)
Colons3
  • Thirty-two weeks later, rats were sacrificed and tumor histology determined, and colons were examined for aberrant crypt foci (ACF). (aacrjournals.org)
  • F. Pierre, A. Freeman, S. Tache, R. Van der Meer and D. E. Corpet, "Beef Meat and Blood Sausage Promote the Formation of Azoxymethane-Induced Mucin-Depleted Foci and Aberrant Crypt Foci in Rat Colons," Journal of Nutrition, Vol. 134, No. 10, 2004, pp. 2711-2716. (scirp.org)
  • The present study was carried out to examine the chemopreventive effects of carotenoids such as fucoxanthin, lycopene and lutein as well as curcumin and its derivative, tetrahydrocurcumin (THC), on development of putative preneoplastic aberrant crypt foci (ACF) in colons of mice initiated with 1,2-dimethylhydrazine dihydrochloride (DMH). (greenmedinfo.com)
Preneoplastic lesions1
  • Here we demonstrate that nullizygous PKCβ (PKCβKO) mice are highly resistant to azoxymethane (AOM)-induced preneoplastic lesions, aberrant crypt foci. (elsevier.com)
Putative preneoplastic1
  • In a single in vivo pet cancers model, crude -mangostin (made up of 78% 956274-94-5 -mangostin and 16% -mangostin) implemented in the dietary plan significantly suppressed development of aberrant crypt foci, regarded as a putative preneoplastic lesion, in rat colon carcinogenesis [13]. (opt-inviral.com)
Epithelial cells2
  • Influence on proliferation of colonic crypt epithelial cells was also assessed in terms of 5-bromo-2'-deoxyuridine (BrdU) incorporation. (greenmedinfo.com)
  • Both sequences involve the progression of normal colon epithelial cells to aberrant crypt foci, followed by early and advanced polyps, and finally advanced cancer. (bosterbio.com)
Colonic crypts3
  • An upwards shift of the proliferative compartment in colonic crypts is reported to be one of the earliest changes in premalignant mucosa. (bmj.com)
  • Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. (nih.gov)
  • HN - 2011 MH - Aberrant Crypt Foci UI - D058739 MN - C4.834.20 MS - Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. (nih.gov)
Carcinogenesis3
  • The efficacy of dietary apigenin, a dietary flavonoid, in colon cancer prevention was investigated by evaluating the inhibition of the ornithine decarboxylase (ODC) activity and the formation of aberrant crypt foci (ACF) and by studying the ability of apigenin to block colon carcinogenesis in two mouse models. (nih.gov)
  • Squalene can significantly suppress colonic aberrant crypt foci (ACF) formation and crypt multiplicity strengthens the hypothesis that squalene possesses chemopreventive activity against colon carcinogenesis. (chemfaces.com)
  • In A/JOlaHsd mice, 5-ASA suppressed digestive tract carcinogenesis by reducing the amount of aberrant crypt foci (75%) and aberrant crypts (22%) induced by AOM treatment with an lack of 5-ASA response after GW9662 administration. (aksumuniversity.org)
Azoxymethane2
  • Chemopreventive effect of raw and cooked lentils (Lens culinaris L) and soybeans (Glycine max) against azoxymethane-induced aberrant crypt foci. (greenmedinfo.com)
  • Almagrami, A. A., M. A. Alshawsh, R. Saif-Ali, A. Shwter, S. D. Salem and M. A. Abdulla (2014) Evaluation of Chemopreventive Effects of Acanthus ilicifolius against Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon. (sussex.ac.uk)
Double-blinded1
  • 2. The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded randomized controlled trial. (nih.gov)
Mice4
  • [ 1 ] in carcinogen-treated mice, and subsequently identified in humans, have been the focus of increasing study in recent years. (medscape.com)
  • Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele. (harvard.edu)
  • Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. (nih.gov)
  • DSS treatment significantly increased numbers of aberrant crypt foci in N0 mice, but not WT mice. (nih.gov)
Mucosa4
  • In normal colonic mucosa the proliferative compartment is confined to the lower half to two thirds of the crypt. (bmj.com)
  • and showed cancer-specific aberrant DNA methylation, whereas, had been methylated in both AOM tumors and regular digestive tract mucosa. (cylch.org)
  • No aberrant methylation of or was discovered in the neoplasms, but regular colon mucosa examples displayed methylation of the genes. (cylch.org)
  • The colonic mucosa is made up of tubular crypts aligned perpendicular to the muscularis mucosae. (allenpress.com)
Occurrence1
  • 4. The Effect of Low Doses of Acetylsalicylic Acid on the Occurrence of Rectal Aberrant Crypt Foci. (nih.gov)
Dysplasia2
  • Cite this: Aberrant Crypt Foci as Biomarkers for Colonic Dysplasia - Medscape - Sep 01, 2005. (medscape.com)
  • [ 27 ] Resection of a large, flat or sessile lesion, particularly when it is removed in pieces, or a polyp with a focus of high-grade dysplasia or cancer is often followed by repeat endoscopy in 3 months to confirm complete excision. (medscape.com)
Significantly1
  • The Selleckchem BI2536 results showed that consumption of medium-level of rice bran significantly reduced the number of aberrant crypt foci (ACF) and altered their distribution. (micrornainhibitors.com)
Inflammatory1
  • One can see crypt branching and irregularity of size and shape, with an increase in chronic inflammatory cells in the lamina propria. (medscape.com)
Tumor1
  • It's been established which the aberrant hypermethylation of tumor suppressor genes can lead to their transcriptional silencing, which may be the mechanism by which DNA methylation is normally thought to promote cancers development. (cylch.org)
Formation2
  • More recently, we have shown that UDCA inhibits AOM-induced hyperproliferation, and aberrant crypt formation and growth. (aacrjournals.org)
  • Angioprevention is a chemoprevention approach that interrupts the formation of new blood vessels when tumour cell foci are in an indolent state. (wordpress.com)
Nutrition2
  • Nutrition research funding trends and focus areas at the US National Cancer Institute. (nih.gov)
  • Trujillo EB, Hays C, Regan K , Ross S, Seifried H. Nutrition research funding trends and focus areas at the US National Cancer Institute. (nih.gov)
Relevance1
  • 1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
Cancers1
  • Furthermore, in relation to mouse types of intestinal cancers and epigenetic modifications, lately, Hahn et al looked into the glutathione peroxidase Gpx1 and Gpx2 dual knockout mouse using the genome wide Bafetinib methylation analytical technique MIRA (Methylated CpG isle recovery assay) and discovered several genes hypermethylated in chronically swollen, aged, or neoplastic tissues, recommending that mouse types of intestinal cancers likely screen aberrant DNA hypermethylation [20]. (cylch.org)
Tissues1
  • For spatio-temporal simulations of crypt-structured tissues we have developed a random event-driven queuing approach. (nih.gov)
Aims1
  • Background and study aims Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. (thieme-connect.de)
Cancer8
  • Aberrant crypt foci and microadenoma as markers for colon cancer. (nih.gov)
  • Thermolyzed protein (casein) promotes aberrant crypt foci and cancer in the rat colon. (greenmedinfo.com)
  • We will focus on adenocarcinoma of the colon and esophagus, as there is substantial evidence for field defects in these two types of cancer. (ejbiotechnology.info)
  • We use the term field defect to indicate our focus on tissue fields for which evidence suggests there are functional defects on the pathway to the development of cancer. (ejbiotechnology.info)
  • In addition, the majority of these scholarly studies focused on fermented GBR items are research, as well as the anti-cancer impact isn't clear thus. (mingsheng88.org)
  • Preliminary research shows that eating almond flour may stop the growth of aberrant crypt foci in the colon, which is a leading cause of colon cancer. (iherb.com)
  • Focus on the interactions of H. pylori with gastric stem/progenitor cells and their microenvironment will be instrumental to decipher the initiation and origin of gastric cancer. (biomedcentral.com)
  • One theory that has gained traction since a hallmark paper was published in 2001 is the cancer stem cell (CSC) hypothesis The investigation and development of the cancer stem cell (CSC) model has received much focus during these years. (leszeljob.com)
Gene Expression1
  • Northern blotting focuses on RNA sequences and is helpful in assessing gene expression. (lecturio.com)
Mutant2
  • Specific to our project: we lack appropriate (epi)genetic data to answer a number of questions related to the spreading of mutant cells and crypts in the tissue of primary interest: Barrett's esophagus. (nih.gov)
  • We have only begun to identify potential collaborations in this field, related to modeling the behavior of aberrant/mutant cells under various conditions, including noxious challenges. (nih.gov)
Liver1
  • Medium term assays based on aberrant crypt foci in colon and liver foci tests have been used to prove that certain compounds that prevented DNA damage by HAAs also reduced their carcinogenic effects. (umn.edu)
Treatment1
  • Aberrant crypt foci were counted 3 weeks after the cessation of DSS treatment. (nih.gov)
Article1
Study1
  • This open-label study enrolled smokers who had aberrant crypt foci (ACF) on screening colonoscopies. (aacrjournals.org)
Occurs1
  • One theory proposes that ulcerative colitis occurs as a direct result of an aberrant immune response to "gut luminal antigen" in a genetically susceptible host. (medscape.com)
Cell1
  • At the lower end of the modeling spectrum, the cell and crypt level, we are still in discovery and learning mode. (nih.gov)
Analysis1
  • Analysis of Aberrant Crypt Foci (ACF) Colonic ACF were analyzed using the method established by Parrot (1987) [23]. (mingsheng88.org)
Review1
  • This review focuses on key diagnostic features that will hopefully allow the surgical pathologist to differentiate normal from abnormal and acute from chronic colitis as well as to identify new forms of colitis and unusual presentations of classic diseases such as ulcerative colitis (UC) and Crohn disease (CD). (allenpress.com)
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