7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
The methyl imidoester of suberic acid used to produce cross links in proteins. Each end of the imidoester will react with an amino group in the protein molecule to form an amidine.
Bifunctional cross-linking agent that links covalently free amino groups of proteins or polypeptides, including those in cell membranes. It is used as reagent or fixative in immunohistochemistry and is a proposed antisickling agent.
Organic esters of sulfuric acid.

9,10-Dimethyl-1,2-benzanthracene (DMBA) is a synthetic, aromatic hydrocarbon that is commonly used in research as a carcinogenic compound. It is a potent tumor initiator and has been widely used to study chemical carcinogenesis in laboratory animals.

DMBA is a polycyclic aromatic hydrocarbon (PAH) with two benzene rings fused together, and two methyl groups attached at the 9 and 10 positions. This structure allows DMBA to intercalate into DNA, causing mutations that can lead to cancer.

Exposure to DMBA has been shown to cause a variety of tumors in different organs, depending on the route of administration and dose. In animal models, DMBA is often applied to the skin or administered orally to induce tumors in the mammary glands, lungs, or digestive tract.

It's important to note that DMBA is not a natural compound found in the environment and is used primarily for research purposes only. It should be handled with care and appropriate safety precautions due to its carcinogenic properties.

Carcinogens are agents (substances or mixtures of substances) that can cause cancer. They may be naturally occurring or man-made. Carcinogens can increase the risk of cancer by altering cellular DNA, disrupting cellular function, or promoting cell growth. Examples of carcinogens include certain chemicals found in tobacco smoke, asbestos, UV radiation from the sun, and some viruses.

It's important to note that not all exposures to carcinogens will result in cancer, and the risk typically depends on factors such as the level and duration of exposure, individual genetic susceptibility, and lifestyle choices. The International Agency for Research on Cancer (IARC) classifies carcinogens into different groups based on the strength of evidence linking them to cancer:

Group 1: Carcinogenic to humans
Group 2A: Probably carcinogenic to humans
Group 2B: Possibly carcinogenic to humans
Group 3: Not classifiable as to its carcinogenicity to humans
Group 4: Probably not carcinogenic to humans

This information is based on medical research and may be subject to change as new studies become available. Always consult a healthcare professional for medical advice.

Dimethyl Sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO. It is a polar aprotic solvent, which means it can dissolve both polar and nonpolar compounds. DMSO has a wide range of uses in industry and in laboratory research, including as a cryoprotectant, a solvent for pharmaceuticals, and a penetration enhancer in topical formulations.

In medicine, DMSO is used as a topical analgesic and anti-inflammatory agent. It works by increasing the flow of blood and other fluids to the site of application, which can help to reduce pain and inflammation. DMSO is also believed to have antioxidant properties, which may contribute to its therapeutic effects.

It's important to note that while DMSO has been studied for various medical uses, its effectiveness for many conditions is not well established, and it can have side effects, including skin irritation and a garlic-like taste or odor in the mouth after application. It should be used under the supervision of a healthcare provider.

Dimethyl suberimidate is a homobifunctional cross-linking agent that is used in molecular biology for protein-protein or protein-nucleic acid cross-linking. It is an imidoester with the chemical formula (CH3)2N-CO-[CH2]8-CO-N(CH3)2.

This reagent works by reacting with primary amines (-NH2) on proteins or nucleic acids, forming stable amide bonds between them. The length of the spacer arm (comprising eight methylene groups) provides sufficient distance and flexibility for the cross-linked molecules to maintain their native structures and functions.

Dimethyl suberimidate is used in various applications, such as studying protein-protein interactions, mapping protein domains, and analyzing protein complexes' structures. It is crucial to perform cross-linking reactions under controlled conditions to ensure specificity and minimize non-specific binding.

Dimethyl adipimidate is a chemical compound that is used as a cross-linking agent in various biochemical and medical applications. It is an imidate ester of adipic acid, which contains two reactive dimethylamino groups. These groups can react with amino groups on proteins or other molecules to form covalent bonds, creating a cross-linked network.

In the context of medical research and diagnostics, dimethyl adipimidate is sometimes used to modify proteins in order to study their structure and function. For example, it can be used to create stable, cross-linked complexes between different proteins or protein domains, which can then be analyzed using various biochemical techniques.

It's important to note that dimethyl adipimidate is not a drug or therapeutic agent itself, but rather a tool used in laboratory research and diagnostics. As with any chemical compound, it should be handled with care and used only by trained professionals in a controlled environment.

Sulfuric acid esters, also known as sulfate esters, are chemical compounds formed when sulfuric acid reacts with alcohols or phenols. These esters consist of a organic group linked to a sulfate group (SO4). They are widely used in industry, for example, as detergents, emulsifiers, and solvents. In the body, they can be found as part of various biomolecules, such as glycosaminoglycans and steroid sulfates. However, excessive exposure to sulfuric acid esters can cause irritation and damage to tissues.

... vitamin k 1 MeSH D04.615.638.721.374.844 - vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1- ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 - fusidic acid MeSH D04.808.247.808.607 - lanosterol MeSH D04.808.247.808.756 - ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ...
N-dimethyl)benzenamine 4,4'-Methylenediphenyl diisocyanate 2-Methylfluoranthene 3-Methylfluoranthene Methylglyoxal Methyl ... 2 HC Red No. 3 HC Yellow No. 4 Hepatitis D virus Hexachlorobutadiene Hexachlorophene Human T-cell lymphotropic virus type II ... 9 Dapsone Decabromodiphenyl oxide Deltamethrin Diacetylaminoazotoluene Diallate 1,2-Diamino-4-nitrobenzene 1,4-Diamino-2- ... nitrobenzene 2,5-Diaminotoluene Diazepam Diazomethane Dibenz[a,c]anthracene Dibenz[a,j]anthracene Dibenzo-p-dioxin Dibenzo[a,e] ...
... vitamin k 1 MeSH D04.615.638.721.374.844 - vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1- ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 - fusidic acid MeSH D04.808.247.808.607 - lanosterol MeSH D04.808.247.808.756 - ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ...
Dimethyl sulfoxide (DMSO) was used as the vehicle. ... Reference 2. Endpoint:. in vitro gene mutation study in ... Only 2 members of this category have in vivo mutagenicity micronucleus data. However, all 11 of these substances have in vivo ... dose volume of 10 ml/kg body weight and euthanized at 24, 48, or 72 hours post dosing.. Frequency of treatment:. Once. Post ... EGG: 0, 0.3, 1, 3.3, 10, 20, 33, 100, 333 and 666 µg/plate.. SRI: 0, 3.3, 10, 33.3, 100 and 333 µg/plate.. Vehicle / solvent:. ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(1), 207-212. ... MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics ... MeSH headings : 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine / ... Cyclin-Dependent Kinase 2; Enzyme Inhibitors / metabolism; Genes, ras; Mice; Mitogen-Activated Protein Kinases / genetics; ...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ All content on this site: Copyright © 2024 Elsevier B.V. or its licensors and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
Dimethyl sulfoxide (DMSO) was used as the vehicle. ... Reference 2. Endpoint:. in vitro gene mutation study in ... Only 2 members of this category have in vivo mutagenicity micronucleus data. However, all 11 of these substances have in vivo ... dose volume of 10 ml/kg body weight and euthanized at 24, 48, or 72 hours post dosing.. Frequency of treatment:. Once. Post ... EGG: 0, 0.3, 1, 3.3, 10, 20, 33, 100, 333 and 666 µg/plate.. SRI: 0, 3.3, 10, 33.3, 100 and 333 µg/plate.. Vehicle / solvent:. ...
6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate" EXACT [] is_a: XCO:0000140 ! vasodilator is_a: XCO:0000269 ... STZ can be used to treat pancreatic islet cell cancers and to model type 1 diabetes mellitus in animals via destruction of the ... Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon ... Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon ...
17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione use Promegestone ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...
17,21-Dimethyl-19-nor-4,9-Pregnadiene-3,20-dione use Promegestone ... 2-Fluoro-2-deoxyglucose use Fluorodeoxyglucose F18 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10- ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 2-PAM Compounds use ...
17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione use Promegestone ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...
METHODS: Animal models of buccal carcinoma in golden hamster were established by painting 0.5% dimethyl-benzanthracene. The ... 1. Bioinformatic analysis and verification of a lipid metabolism-related long noncoding RNA prognostic signature for head and ... 2. Influence of preoperative simulation on the reduction quality and clinical outcomes of open reduction and internal fixation ... 10. Efficacy and safety of percutaneous microwave coagulation therapy followed by 125I seed brachytherapy for VX2 hepatic ...
dimethyl benzanthracene. UV radiation. ethylene oxide. methylcholanthrene. oryzalin. PAHs. pesticides. We are aware of a number ... 04/10/2017. Categories Dáil ÉireannTags Aengus Ó Snodaigh, air corps, Ardrox 666, chemicals, cresylic acid, defence forces, ... 04/10/2017. Categories Dáil ÉireannTags Aengus Ó Snodaigh, air corps, Carbon Monoxide, cresylic acid, defence forces, Delay ... 1). *People in residential areas where homes are heated with coal, oil, or wood may be exposed to mixed cresols in the air. (1) ...
MeSH Terms: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Checkpoint Kinase 2; Female; Fibroblasts/metabolism; ...
Kelly E Leon 1 2 , Raquel Buj 1 , Elizabeth Lesko 3 , Erika S Dahl 2 , Chi-Wei Chen 1 , Naveen Kumar Tangudu 1 , Yuka Imamura- ... Kelly E Leon 1 2 , Raquel Buj 1 , Elizabeth Lesko 3 , Erika S Dahl 2 , Chi-Wei Chen 1 , Naveen Kumar Tangudu 1 , Yuka Imamura- ... 1. (A) Timeline of experiments. (B-I, K, and N) BJ-hTERT cells were infected with retrovirus-expressing BRAFV600E (BRAF) or ... Figure 2. DOT1L is necessary for H3K79me2/3 at the IL1A locus and SASP expression but dispensable for other senescence ...
Deepti Bajpai 1 , Spencer Mehdizadeh 1 , Akihiko Uchiyama 2 , Yuta Inoue 2 , Andrew Sawaya 1 , Andrew Overmiller 1 , Stephen R ... Deepti Bajpai 1 , Spencer Mehdizadeh 1 , Akihiko Uchiyama 2 , Yuta Inoue 2 , Andrew Sawaya 1 , Andrew Overmiller 1 , Stephen R ... 1 , Elisabetta Palazzo 1 , Sei-Ichiro Motegi 2 , Stuart H Yuspa 4 , Christophe Cataisson 4 , Maria I Morasso 5 ... 1 , Elisabetta Palazzo 1 , Sei-Ichiro Motegi 2 , Stuart H Yuspa 4 , Christophe Cataisson 4 , Maria I Morasso 5 ...
2. Regulation of cyclic AMP and cyclic GMP in Morris hepatomas and liver.. Hickie RA. Adv Exp Med Biol; 1977 May 22-24; 92(): ... 9. Cyclic GMP system in the epidermis.. Adachi K; Aoyagi T; Iizuka H; Halprin KM; Levin V. Curr Probl Dermatol; 1980; 10():39- ... 10. The formation, degradation, and function of cyclic nucleotides in the nervous system.. Daly JW. Int Rev Neurobiol; 1977; 20 ... 1. Cyclic nucleotides in stroke and related cerebrovascular disorders.. Palmer GC. Life Sci; 1985 May; 36(21):1995-2006. PubMed ...
1-Oct-2005.. Perera F, Tang D, Rauh V, Lester K, Tsai W, Tu Y, Weiss L, Hoepner L, King J, Del Priore G and Lederman S (2005) ... 1-Oct-2005.. Weis B, Balshaw D, Barr J, Brown D, Ellisman M, Lioy P, Omenn G, Potter J, Smith M, Sohn L, Suk W, Sumner S, ... 1-Feb-2018.. Wheelock K, Zhang J, McConnell R, Tang D, Volk H, Wang Y, Herbstman J, Wang S, Phillips D, Camann D, Gong J and ... 1-Jan-2014.. Tang D, Li T, Chow J, Kulkarni S, Watson J, Ho S, Quan Z, Qu L and Perera F (2014) Air pollution effects on fetal ...
Benz(a)anthracene, 7,12-dimethyl-. Previous Indexing. Benzanthracenes (1966-1974). Public MeSH Note. 85; was see under ... 9,10-Dimethyl-1,2-benzanthracene Preferred Term Term UI T044224. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... 9,10-Dimethyl-1,2-benzanthracene Preferred Concept UI. M0023271. Registry Number. 57-97-6. Scope Note. Polycyclic aromatic ... 9,10-Dimethyl-1,2-benzanthracene. Tree Number(s). D02.455.426.559.847.149.301. D04.615.149.301. Unique ID. D015127. RDF Unique ...
Benz(a)anthracene, 7,12-dimethyl-. Previous Indexing. Benzanthracenes (1966-1974). Public MeSH Note. 85; was see under ... 9,10-Dimethyl-1,2-benzanthracene Preferred Term Term UI T044224. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... 9,10-Dimethyl-1,2-benzanthracene Preferred Concept UI. M0023271. Registry Number. 57-97-6. Scope Note. Polycyclic aromatic ... 9,10-Dimethyl-1,2-benzanthracene. Tree Number(s). D02.455.426.559.847.149.301. D04.615.149.301. Unique ID. D015127. RDF Unique ...
The ingestion of 14C-labeled 9,10-dimethyl-1,2-benzanthracene particles, the extracellular release of acid phosphatase, ... The ingestion of 14C-labeled 9,10-dimethyl-1,2-benzanthracene particles, the extracellular release of acid phosphatase, ... Desmethylimipramine acted within 1 h to increase acid hydrolase release, but the effect of dichloroisoproterenol developed more ... The ingestion of 14C-labeled 9,10-dimethyl-1,2-benzanthracene particles, the extracellular release of acid phosphatase, ...
N-dimethyl-N-2-propenyl-), Dibromide N0000168635 Phosphatidylinositol 4,5-Diphosphate N0000167926 3-Oxo-5-alpha-Steroid 4- ... 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester N0000166441 Phenylphosphonothioic Acid, 2-Ethyl 2-(4- ... Sodium Salt N0000006711 Dimethyl Sulfoxide N0000180241 Methionine Sulfoxide Reductases N0000170267 Methionine Sulfoximine ... Neuronal N0000170584 Focal Adhesion Protein-Tyrosine Kinases N0000011363 Tissue Adhesives N0000166723 Dimethyl Adipimidate ...
Hence the present study was designed to investigate the combined efficacy of TAM along with CoQ10 in 7, 12 dimethyl benz(a) ... Mammary carcinoma was induced with 7,12-dimethyl benz(a)anthracene (DMBA: 25 mg), and the treatment was started by the oral ... 12-dimethyl benz(a)anthracene (DMBA)-induced oral carcinogenesis by evaluating the status of lipid peroxidation, antioxidants ... 2. Increase of antitumor activity of cisplatin using agonist of gonadotropin-realising hormone and inhibitor of aromatase on ...
It has been found that the purified enzyme splits N-dimethyl amines into the corresponding aldehyde and dimethyl- amine and ... in the ten- NATIONAL HEART INSTITUTE 109 sion developed during systole, and in the rate of development of tension takes place. ... 4-dimethyl-a-pyrone-6-carboxylic acid and oxamide are 6,7-dimethyl-2,3,5-quinoxa1ine- triol and 3,4-dimethyl-a-pyrone-6- ... This com- pound is subsequently converted to 6,7-dimethyl- 2,3-quinoxalinediol by an oxygen dependent cleavage of the N-ribityl ...
17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione use Promegestone ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...
MH DELETED MN ADDED MN --------------------------------------- ---------- -------- 1-Deoxynojirimycin D3.383.621.180 D2.491. ... pyrene 9,10-oxide D2.455.426.559.847.799.306.400.350 8,11,14-Eicosatrienoic Acid D10.251.355.255.74 D10.251.355.255.207 8-Bromo ... Type 1 D8.811.913.696.620.682.725.400.24 D8.811.913.696.620.682.725.400.177 D12.776.543.750.60.61 D12.776.543.750.60.440 ... F3.80.931.550 Stromelysin 1 D8.811.277.656.300.480.525.810 D8.811.277.656.300.480.525.700.200 D8.811.277.656.675.374.525.810 ...
Descritores em Ciências da Saúde
Go to MDM-2 protein is expressed in different layers of normal human skin.. MDM-2 is one of the target genes of the p53 tumor ... T-2 toxin induced skin inflammation and cutaneous injury in mice.. T-2 toxin induced skin inflammation and cutaneous injury in ... PY - 2019/1/1. Y1 - 2019/1/1. N2 - Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to ... JCI - IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. The results of this study suggest that IL- ...
Ten animals received 100 microg rcSCF/kg/day b.i.d. by subcutaneous injection on days 1 through 10 after 920 cGy total body ... Ten-minute samples were collected for pulse analysis after progesterone removal and hourly for comparisons during the estradiol ... In Austria, ten clinically diagnosed cases of nephropathia epidemica, presumably caused by Puumala virus infection, have been ... Ten patients presented with acute onset of upper extremity swelling and axillosubclavian vein thrombosis. One patient presented ...
  • Following ECHA decision (CCH-D-2114379324-45-01/F) on Benzyl Salicylate it was requested to conduct additional toxicological studies: among others - In vitro cytogenicity study in mammalian cells (Annex VIII, Section 8.4.2. (europa.eu)
  • 2021 Aug 2;220(8):e202008101. (nih.gov)
  • 13. Cyclic nucleotides and their associated enzymes in 9,10-dimethyl-1,2-benzanthracene-induced mammary tumors of rats. (nih.gov)
  • MATERIALS AND METHODS: 72 female Wistar rats, which underwent intraperitoneal transplantation of ascitic TOT, by 5·10(6) cells per animal, have been involved in the study. (bvsalud.org)
  • Rats were divided into 8 groups, 9 rats in each group. (bvsalud.org)
  • PMID- 9298188 OWN - NLM STAT- MEDLINE DA - 19971117 DCOM- 19971117 LR - 20061115 PUBM- Print IS - 0003-6072 (Print) VI - 72 IP - 2 DP - 1997 Aug TI - Formation of formate and hydrogen, and flux of reducing equivalents and carbon in Ruminococcus flavefaciens FD-1. (nih.gov)
  • 4. Cyclic AMP and cyclic GMP phosphodiesterase inhibition by an antiplatelet agent, 6-[(3-methylene-2-oxo-5-phenyl-5-tetrahydrofuranyl)methoxy)quinol inone (CCT-62). (nih.gov)
  • The ingestion of 14 C-labeled 9,10-dimethyl-1,2-benzanthracene particles, the extracellular release of acid phosphatase, ribonuclease, and α-glucosidase, and the egestion of preingested dimethylbenzanthracene particles by Tetrahymena taken from logarithmically growing cultures and resuspended in a dilute salt solution were followed in the presence of several pharmacologic agents. (rupress.org)
  • Desmethylimipramine acted within 1 h to increase acid hydrolase release, but the effect of dichloroisoproterenol developed more slowly and was secondary to a change in cellular content of the hydrolases. (rupress.org)
  • 10. The formation, degradation, and function of cyclic nucleotides in the nervous system. (nih.gov)
  • Interestingly, the inhibition of DMBA-induced DNA adduct formation was associated with proportional decrease in CYP1A1 and in NAD(P)H: quinone oxidoreductase 1 (NQO1) gene expression. (bvsalud.org)
  • National Cancer Institute 1 Introduction 1 Clinical investigations 3 Origins of the cancerous state 4 Development of clinical cancer 5 Autonomy 5 Spread of cancer 6 Wound washings 6 Cancer cells in circulating blood 7 Spread of tumor in animal models. (nih.gov)
  • Mechanistically, the involvements of AhR and nuclear factor erythroid 2-related factor-2 (Nrf2) in the MET-mediated inhibition of DMBA-induced CYP1A1 and NQO1 gene expression were evidenced by the ability of MET to inhibit DMBA-induced xenobiotic responsive element and antioxidant responsive element luciferase reporter gene expression which suggests an AhR- and Nrf2-dependent transcriptional control. (bvsalud.org)
  • RESULTS: Bupivacaine, in a concentration-dependent manner (10-300 microM), tonically inhibited the peak amplitude of ICa,L. The inhibition was characterized by an increase in the time of recovery from inactivation and a negative-voltage shift of the steady-state inactivation curve. (nih.gov)
  • 1 Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA. (nih.gov)