7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
The methyl imidoester of suberic acid used to produce cross links in proteins. Each end of the imidoester will react with an amino group in the protein molecule to form an amidine.
Bifunctional cross-linking agent that links covalently free amino groups of proteins or polypeptides, including those in cell membranes. It is used as reagent or fixative in immunohistochemistry and is a proposed antisickling agent.
Organic esters of sulfuric acid.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
The science of developing, caring for, or cultivating forests.
The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Scattering of a beam of electromagnetic or acoustic RADIATION, or particles, at small angles by particles or cavities whose dimensions are many times as large as the wavelength of the radiation or the de Broglie wavelength of the scattered particles. Also know as low angle scattering. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Small angle scattering (SAS) techniques, small angle neutron (SANS), X-ray (SAXS), and light (SALS, or just LS) scattering, are used to characterize objects on a nanoscale.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Inorganic derivatives of phosphoric acid (H3PO4). Note that organic derivatives of phosphoric acids are listed under ORGANOPHOSPHATES.
A species of bacteria that resemble small tightly coiled spirals. Its organisms are known to cause abortion in sheep and fever and enteritis in man and may be associated with enteric diseases of calves, lambs, and other animals.
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
Polysaccharides found in bacteria and in capsules thereof.
An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
Fields representing the joint interplay of electric and magnetic forces.
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
Polymeric derivatives of GALLIC ACID that are esters of a sugar.
A plant genus of the family FAGACEAE that is a source of TANNINS. Do not confuse with Holly (ILEX).
Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions.
Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.
A process of preserving animal hides by chemical treatment (using vegetable tannins, metallic sulfates, and sulfurized phenol compounds, or syntans) to make them immune to bacterial attack, and subsequent treatments with fats and greases to make them pliable. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Tumors or cancer of the SKIN.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Tumors or cancer of the human BREAST.
A cell line derived from cultured tumor cells.
... vitamin k 1 MeSH D04.615.638.721.374.844 - vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1- ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 - fusidic acid MeSH D04.808.247.808.607 - lanosterol MeSH D04.808.247.808.756 - ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ...
N-dimethyl)benzenamine 4,4'-Methylenediphenyl diisocyanate 2-Methylfluoranthene 3-Methylfluoranthene Methylglyoxal Methyl ... N-Dimethylaniline Dimethylformamide Dimethyl hydrogen phosphite 1,4-Dimethylphenanthrene 3,5-Dinitrotoluene ... 2 HC Red No. 3 HC Yellow No. 4 Hepatitis D virus Hexachlorobutadiene Hexachlorophene Human T-cell lymphotropic virus type II ... 9 Dapsone Decabromodiphenyl oxide Deltamethrin Diacetylaminoazotoluene Diallate 1,2-Diamino-4-nitrobenzene 1,4-Diamino-2- ...
N-dimethyl)benzenamine 4,4'-Methylenediphenyl diisocyanate 2-Methylfluoranthene 3-Methylfluoranthene Methylglyoxal Methyl ... N-Dimethylaniline Dimethylformamide Dimethyl hydrogen phosphite 1,4-Dimethylphenanthrene 3,5-Dinitrotoluene ... 2 HC Red No. 3 HC Yellow No. 4 Hepatitis D virus Hexachlorobutadiene Hexachlorophene Human T-cell lymphotropic virus type II ... 9 Dapsone Decabromodiphenyl oxide Deltamethrin Diacetylaminoazotoluene Diallate 1,2-Diamino-4-nitrobenzene 1,4-Diamino-2- ...
AS hepatic damage was shown to protect the adrenal glands against necrosis it appears that the metabolic conversion of 9;10- ... dimethyl-1;2-benzanthracene to an adrenolytic derivative is a function of the liver. In order to assess degrees of liver damage ... Kernohan, Ian Riddell (1971) The influence of liver function on the adrenolytic and carcinogenic action of 9,10-dimethyl-1,2 ... The influence of liver function on the adrenolytic and carcinogenic action of 9,10-dimethyl-1,2 benzanthracene ...
9,10-Dimethyl-1,2-benzanthracene/pharmacology , Animals , Cell Differentiation/drug effects , Cell Division/drug effects , ... Effect of 9,10-dimethyl-1,2-benzanthracene on the growth of hamster dermal fibroblasts in primary culture. ... 9,10-Dimethyl-1,2-benzanthracene / Fibroblasts / Animals Language: English Journal: Indian J Cancer Year: 1991 Type: Article ... 9,10-Dimethyl-1,2-benzanthracene / Fibroblasts / Animals Language: English Journal: Indian J Cancer Year: 1991 Type: Article ...
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Chickens / 9,10-Dimethyl-1,2-benzanthracene / Intestinal ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Chickens / 9,10-Dimethyl-1,2-benzanthracene / Intestinal ... 9,10-Dimethyl-1,2-benzanthracene , Animals , Chickens , Intestinal Neoplasms/chemically induced , Liver Neoplasms/secondary , ... Experimental induction of mesothelioma using 9:10-dimethyl, 1:2-benzanthracene (DMBA) in c ...
1 Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow 226001, India. ... Bcl-2 and survivin by DMBA were downregulated. Further, we showed that tea polyphenols supplementation resulted in release of ...
Nam Deuk Kim 1 , Rajendra Mehta, Weiping Yu, Ishak Neeman, Talia Livney, Akiva Amichay, Donald Poirier, Paul Nicholls, Andrew ... inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor ... inhibited 17-beta-hydroxysteroid dehydrogenase Type 1 from 34 to 79%, at concentrations ranging from 100 to 1,000 microg/ml ...
Other names: DMBA; 7,12-Dimethyl-1,2-benzanthracene; 7,12-Dimethylbenzanthracene; 7,12-Dimethylbenzo[a]anthracene; 7,12- ... C @ 1. min, 4. K/min; Tend: 310. C. Capillary. DB-5MS. 443.82. Chen, Keeran, et al., 2002. 30. m/0.25 mm/0.5 «mu»m, 40. C @ 1. ... Beernaert, H., Gas Chromatographic Analysis of Polyclylic Aromatic Hydrocarbons, J. Chromatogr., 1979, 173, 1, 109-118, https ... m/0.3 mm/0.34 «mu»m, He, 2. K/min; Tstart: 50. C; Tend: 250. C. ...
9,10-Dimethyl-1,2-benzanthracene. Animals. Cheek. Cricetinae. Histocytochemistry. Kinetics. Male. Mesocricetus. Mouth Neoplasms ... During the same 10-week posttreatment period, several dysplastic and occasional neoplastic lesions, some of which displayed ... A comparison of GGT-positive foci at the completion of the DMBA regimen and at 10 weeks thereafter revealed no significant ... 10-Dimethyl-1,2-benzanthracene; EC 2.3.2.2/gamma-Glutamyltransferase From MEDLINE®/PubMed®, a database of the U.S. National ...
9,10-Dimethyl-1,2-benzanthracene. Aminolevulinic Acid / therapeutic use*. Animals. Carcinogens. Carcinoma, Squamous Cell / ... 2505276 - 3-(2-imidazo[4,5-b]pyridine)propionic acid and some of its derivatives with suspected t.... 18962276 - Thiosulphate ... In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2 ... 2913306 - Synthesis and evaluation of antileukemic activity of 5-thienyl- or 5-(2-furyl)-2,3-dihy.... 1724726 - Chemical ...
COFACTOR: Binds 1 Fe(2+) ion per subunit (By similarity).. SUBCELLULAR LOCATION: Mitochondrion.. TISSUE SPECIFICITY: Highly ... DESCRIPTION: RecName: Full=Beta,beta-carotene 9,10-oxygenase; EC=1.14.99.n2; AltName: Full=B-diox-II; AltName: Full=Beta- ... Description: Homo sapiens beta-carotene oxygenase 2 (BCO2), transcript variant 2, mRNA. (from RefSeq NM_001037290). RefSeq ... FUNCTION: Asymmetrically cleaves beta-carotene at the 9,10 double bond resulting in the formation of beta-apo-10-carotenal ...
Diseases sorted by gene-association score: lung cancer (4), attention deficit-hyperactivity disorder (2), colorectal cancer (1 ... Alternate Gene Symbols: A8W476, A8W477, CAD13_HUMAN, CDHH, NM_001220491, P55290, Q6GTW4, Q8TBX3, uc010chh.1, uc010chh.2, ... EU190357 - Homo sapiens cadherin 13 soluble isoform 2 (CDH13) mRNA, complete cds, alternatively spliced.. EU190358 - Homo ... sapiens cadherin 13 soluble isoform 1 (CDH13) mRNA, complete cds, alternatively spliced.. AK307862 - Homo sapiens cDNA, ...
Application: Solvent dimethyl sulfoxide (CAS No. 67-68-5) - Positive and negative control groups and treatment: Negative: Blank ... The starting component 2,3-epoxypropyl neodecanoate, which is mutagenic in vitro, and in vivo, as has been shown in bacterial ... Reference 2. Endpoint:. in vitro gene mutation study in mammalian cells. Remarks:. Type of genotoxicity: gene mutation. Type of ... Reference 1. Endpoint:. in vitro gene mutation study in bacteria. Remarks:. Type of genotoxicity: gene mutation. Type of ...
9,10-Dimetil-1,2-benzantraceno/toxicidade. Animais. Antineopl sicos/uso terap utico. Antineopl sicos/toxicidade. Carbodi-Imidas ... We show UDP-GlcNAc to be a specific substrate for Ab-WbjB, with binding evident by ITC (Ka = 0.23 mol-1). The sequence of Ab- ... The absence of MeOPN-4-Gal resulted in enhanced sensitivity to serum killing, whereas the loss of MeOPN-2-Gal and MeOPN-6-Gal ... strain 81-176 contains two MeOPN transferase genes and has been shown previously to contain MeOPN modifications at the 2 and 6 ...
Ten Brinke A; Dekkers DW; Notten SM; Karsten ML; de Groot ER; Aarden LA. ... 9,10-Dimetil-1,2-benzantraceno/toxicidade. Animais. Carcin genos/toxicidade. Transforma o Celular Neopl sica/induzido ... Analytes were stable in plasma for 24 h at room temperature, 9 days at 4 degrees C, and 45 days at -20 degrees C and -70 ... The resultant 4-butyl-4-hydroxy-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione (4-OH-OPB) killed both replicating and NR ...
NIOSHTIC-2 Publications Search. Search Results. Search for NIOSH Publications:. *Advanced Search ... 9, 10 Dimethyl 1,2 benzanthracene (DMBA) also induced ODC activity of MCF-7 cells in similar manner. In contrast, ODC activity ... Melatonin induced ODC activity significantly in MCF-7 cells with 1 nM concentration at 12h. Studies are underway to determine ... Proceedings of the Eighty-Ninth Annual Meeting of the American Association for Cancer Research, March 28 - April 1, 1998, New ...
Table 1. Results of genotoxicity assays with diminazene Test system Test object Concentration Results Reference Ames test1 S. ... 4 9,10-dimethyl-1,2-benzanthracene was used as the positive control. 3. COMMENTS Diminazene was negative in the micronucleus ... 2. BIOLOGICAL DATA 2.1 Biochemical aspects The excretion of diminazene into milk was examined in four lactating cows, each ... 2 Reviewed at the thirty-fourth Meeting of the Committee. 3 Ethylmethansulfonate was used as the positive control. ...
Outbred CD-1 and outbred Sencar mice received a single topical application of the hydrocarbons followed by twice weekly ...
1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and ... 10/01/1988 - "Diagnosis of oak poisoning was made based on the renal lesions and the finding of a high content of tannins in ... 10/05/2015 - "The bradykinin-induced rat pain model was used to assess the analgesic effect of tannic acid. ". 10/05/2015 - " ... 1. Neoplasms (Cancer) 11/01/1989 - "Tumor induction studies in forestomach and lung revealed significant protection against BP- ...
At least 10 fields were recorded for each observation. Two representative images demonstrating effects of different fibroblasts ... At least 10 fields were recorded for each observation. Two representative images demonstrating effects of different fibroblasts ... Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal ... Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal ...
Figure 10: Spalax fibroblasts suppress colony formation of human breast cancer cells MDA-MB-231 and MCF7 in soft agar. (A) MDA- ... Figure 10: Spalax fibroblasts suppress colony formation of human breast cancer cells MDA-MB-231 and MCF7 in soft agar. (A) MDA- ... Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal ... Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal ...
MMHCdb has been designed to aid researchers in such areas as choosing experimental models, reviewing patterns of mutations in specific cancers, and identifying genes that are commonly mutated across a spectrum of cancers.
N-dimethyl-4-aminoazobenzene in the rat. Cancer Res. 39: 112-115.PubMedGoogle Scholar ... 1.. Deelman, H.T. 1927. The part played by injury and repair in the development of cancer. Brit. Med. J. 1: 872.Google Scholar ... In: Carcinogenesis, Volume 2. T.J. Slaga, A. Sivak, and R.K. Boutwell, eds. Raven Press: New York. pp. 421-432.Google Scholar ... Tumors in CF-1 mice exposed for six consecutive generations to DDT. J. Natl. Cancer Inst. 51: 983-997.Google Scholar ...
The oral LD50 of a major plant metabolite, DMST (N,N-dimethyl-N-p-tolylsulphamide), exceeds 2500 mg/kg in rats and 1000 mg/kg ... F1b animals (20 females-10 males/dose) were then mated and F1a and F1b generations were obtained. The study was ended when F1b ... After 70 days of treatment F0 animals were mated on a 2-female-to-1-male basis. After delivery (F1a) and a 4-week lactation and ... Rat M inhalation* - 265 2/ Kimmerle & Lorke, 1967 (4-hr exp.) Rat M i.p. 20.2 1/ - Kimmerle, 1968 Rat F i.p. 25.6 1/ - Kimmerle ...
1 C shows a Southern blot analysis of AAA-flox-neo and AAA alleles, and Fig. 1 D shows PCR genotyping of a litter derived from ... 2 B). By 24 h, most of the mutant cells had reached an 8-N DNA content. At this point, some of the wild-type cells also adapted ... 2 A), although the level in Cdc20+/AAA-flox-neo cells showed a slight decrease, most likely because the AAA-flox-neo allele is ... Figure 2. Cdc20AAA disrupts SAC. (A) Western blot analysis of Cdc20 expression. (B) FACS profiles of the cells treated with 80 ...
In the human body, around 60% of zinc is present in muscles, 30% in bones, and the remaining 10% in skin, hair, pancreas, ... Oral Health Care 2018, 2. [Google Scholar] [CrossRef]. *Yang, Y.F.; Zhu, W.Q.; Cheng, K.; Chen, Q.X.; Xu, Y.; Pang, Y.; Liu, G. ... J. Cancer Manag. 2017, 10, e9252. [Google Scholar] [CrossRef]. *Shuai, T.; Tian, X.; Shi, B.; Chen, H.; Liu, X.L.; Yi, L.J.; ... 1. Introduction. The optimal level of zinc is important for the growth and development of human health [1]. In the human body, ...
10.↵ Collins, C. M., and P. G. Medveczky. 2001. Oncogenic transformation of T cells by Herpesvirus saimiri, p. 140-158. In L. J ... 9.↵ Christensen, J. P., R. D. Cardin, K. C. Branum, and P. C. Doherty. 1999. CD4(+) T cell-mediated control of a gamma- ... 2.↵ Bais, C., B. Santomasso, O. Coso, L. Arvanitakis, E. G. Raaka, J. S. Gutkind, A. S. Asch, E. Cesarman, M. C. Gershengorn, E ... 1.↵ Ambinder, R. F. 2000. Gammaherpesviruses and "Hit-and-Run" oncogenesis. Am. J. Pathol. 156:1-3. ...
The growth of the DMBA-induced rat mammary carcinoma was inhibited by doses ranging from 1 to 12 mg/kg. The maximum decrease of ... The growth of the DMBA-induced rat mammary carcinoma was inhibited by doses ranging from 1 to 12 mg/kg. The maximum decrease of ... The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) on estrogen-dependent mammary tumors ... The growth of estrogen receptor-positive MCF-7 breast cancer cells was inhibited by the hydroxy derivative D 15414 (10(-8)-10(- ...
Y1 - 2020/2/1. N2 - Breast cancers evolve in a multistage process that can span decades after a carcinogenic exposure. It ... 2, 01.02.2020, p. 173-184.. Research output: Contribution to journal › Article ... Cancer prevention research (Philadelphia, Pa.), 13(2), 173-184. https://doi.org/10.1158/1940-6207.CAPR-19-0322 ...
Tested on the 9,10-dimethyl-1,2-benzanthracene-induced hormone-dependent mammary adenocarcinoma of the Sprague-Dawley rat all ...
Lin, J. M., Amin, S., Trushin, N. & Hecht, S. S., Nov 1 1993, In : Cancer Letters. 74, 3, p. 151-159 9 p.. Research output: ... El-bayoumy, K., Upadhyaya, P., Desai, D. H., Amin, S. & Hecht, S. S., Jun 1 1993, In : Carcinogenesis. 14, 6, p. 1111-1113 3 p. ... Amin, S., Desai, D. & Hecht, S. S., Oct 1 1993, In : Carcinogenesis. 14, 10, p. 2033-2037 5 p.. Research output: Contribution ... Wagner, A. J., Meyers, C., Laimins, L. A. & Hay, N., Nov 1 1993, In : Cell Growth and Differentiation. 4, 11, p. 879-884 6 p.. ...
  • One of the first models of experimental carcinogenesis in animals was carried out by Salley in 1954 [ 1 ]. (intechopen.com)
  • Subsequently, several authors have standardized this model and repeated it in order to achieve new knowledge about DMBA and the process of experimentally induced carcinogenesis [ 2 , 3 ]. (intechopen.com)
  • The synergistic effect of 9.10-dimethyl-1.2-benzanthracene and colchicine in skin carcinogenesis in mice. (nih.gov)
  • Carcinogenesis, in many of the major organs, is a long process spanning 10 to 30 years starting from initiated cells and advancing to invasive cancer, theoretically providing a long "intervention window. (aacrjournals.org)
  • While all mice and rats developed the expected tumors following treatment with both carcinogens, among Spalax no tumors were observed after DMBA/TPA treatment, while 3MCA induced benign fibroblastic proliferation in 2 Spalax individuals out of12, and only a single animal from the advanced age group developed malignancy 18 months post-treatment. (nih.gov)
  • After applying various carcinogens, including 9,10-dimethyl-1,2 benzanthracene on the oral epithelium of Syrian hamsters for 3 months, Salley was able to verify the existence of squamous cell carcinomas (SCC) and lymphatic metastases. (intechopen.com)
  • Experimental induction of mesothelioma using 9:10-dimethyl, 1:2-benzanthracene (DMBA) in chicken. (bvsalud.org)
  • Tea polyphenols treatment along with DMBA exposure resulted in upregulation of p53, and proapoptotic protein Bax, whereas enhanced expression of antiapoptotic proteins, Bcl-2 and survivin by DMBA were downregulated. (nih.gov)
  • A comparison of GGT-positive foci at the completion of the DMBA regimen and at 10 weeks thereafter revealed no significant decrease in either the number or the size of the foci. (biomedsearch.com)
  • During the same 10-week posttreatment period, several dysplastic and occasional neoplastic lesions, some of which displayed patchy GGT activity, developed in the pouch epithelium of DMBA-treated animals. (biomedsearch.com)
  • In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA). (biomedsearch.com)
  • 9, 10 Dimethyl 1,2 benzanthracene (DMBA) also induced ODC activity of MCF-7 cells in similar manner. (cdc.gov)
  • The growth of the DMBA-induced rat mammary carcinoma was inhibited by doses ranging from 1 to 12 mg/kg. (uni-regensburg.de)
  • We investigated a sex differences and the effects of ovariectomy on the histology of 9,10-dimethyl-1-,2-benzanthracene (DMBA)-induced adenocarcinomas in the submandibular gland of rats. (nii.ac.jp)
  • Wistar rats, (7 weeks-age, 58 females and 5 males) were divided four groups : (1) non ovariectomy, (2) ovariectomy, (3) Tamoxifen application, anti-estrogen Tamoxifen application after development of DMBA-induced adenocarcinoma (4) male rats. (nii.ac.jp)
  • In thirty-two females non-ovariectomized rats a 0.1 ml of 1% DMBA dissolved in acetone was injected directly into the submandibular glands biweekly. (nii.ac.jp)
  • In contrast, identical treatment with N-OH-3-ABA resulted in adduct levels in the same range as with DMBA (136+/-25 adducts/10(8) nucleotides), indicating that initial DNA adduct levels do not parallel tumour initiating activity. (openrepository.com)
  • Interventions: A control group of 20 hamsters received application of the carcinogen 9,10- dimethyl-1,2-benzanthracene (DMBA) to their cheek pouch mucosa. (elsevier.com)
  • The effect of zinc on 9, 10 dimethyl- 1, 2 benzanthracene(DMBA) induced salivary gland tumours in the albino rat. (wits.ac.za)
  • Of six tumors from DMBA/TPA-treated FVB/N mice, three had trisomy 10 or 15 (or both), and two appeared normal. (elsevier.com)
  • Since estrogenic exposures early in life modify susceptibility to develop breast cancer, we wondered whether maternal dietary intake of 5% or 10% flaxseed during pregnancy or lactation (between postpartum days 5 and 25) might affect 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis in the rat offspring. (nih.gov)
  • Female Sprague-Dawley rats were fed a purified diet containing olive oil (m-monoene fat), partially hydro-genated corn oil (trans-monoene fat), or a blend of these two oils at the 10% level and received a single oral dose of 7,12-dimethylbenz(a)anthra-cene (DMBA). (elsevier.com)
  • The animals were orally administered with PE (0.2-5.0 g/kg), starting 2 wk before and 16 wk following DMBA treatment. (omeka.net)
  • strain 81-176 contains two MeOPN transferase genes and has been shown previously to contain MeOPN modifications at the 2 and 6 positions of the galactose (Gal) moiety in the CPS. (bireme.br)
  • We tested the role of aryl hydrocarbon receptor (Ahr) gene polymorphism in the inflammatory response and in skin and lung tumori genes is in 2 lines of mice phenotypically selected for maximum or minimum acute inflammatory reaction (AIRmax and AIRmin, respectively). (elsevier.com)
  • In skin tissue, transcript levels of ILlβ, Tnf, 06, Tgfβ 1 and Cyplbl genes were unregulated in AIRmin but not AIRmax mice, consistent with the inflammatory responses to the carcinogen. (elsevier.com)
  • Activated Ha-ras genes with 61st codon A → T mutations were found in the epidermis of mice 1 week after topical initiation with 7,12-dimethylbenz[a]anthracene or urethane by using this assay. (elsevier.com)
  • Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast cancer cells at 50 microg/ml. (nih.gov)
  • Here, we show that multidomain proapoptotic Bcl-2 family members Bax and Bak play a critical role in apoptosis induction by sulforaphane. (aacrjournals.org)
  • Tissues from Chk2 -/- mice, including those from the thymus, central nervous system, fibroblasts, epidermis, and hair follicles, show significant defects in IR-induced apoptosis or impaired G 1 /S arrest. (elsevier.com)
  • Quantitative comparison of the G 1 /S checkpoint, apoptosis, and expression of p53 proteins in Chk2 -/- versus ATM -/- thymocytes suggested that Chk2 can regulate p53-dependent apoptosis in an ATM-independent manner. (elsevier.com)
  • Of seven bioflavonoids screened, galangin (3,5,7-trihydroxyflavone) blocked PAH-induced but not C(2)-ceramide- or H(2)O(2)-induced pre-B cell apoptosis. (mblwhoilibrary.org)
  • It has been shown that a number of proteins of herpes simplex virus type 1 (HSV- 1) are phosphorylated and HSV-1 encodes viral PKs, but the role of phosphorylation of viral proteins in HSV-1 infection has not been clarified. (nii.ac.jp)
  • In the present study, the effects of PK inhibitors including protein tyrosine kinase (PTK) inhibitors, genistein and tyrphostin, and protein kinase C (PKC) inhibitor, 1-(5-isoquinoline- sulfonyl)-2-methylpiperazine (H-7), on the replication of HSV-1 and phosphorylation of viral proteins were examined. (nii.ac.jp)
  • The HSV-1 proteins which have phosphorylated tyrosine residues and suppressed by tyrphostin 9 most significantly were the products of the UL47 gene, the tegument proteins VP13/14. (nii.ac.jp)
  • The difference in the fatty acid composition of dietary fats was confined to the geometry of octadecenoate with an appropriate supply of linoleic acid (2% of total energy). (elsevier.com)
  • Outbred CD-1 and outbred Sencar mice received a single topical application of the hydrocarbons followed by twice weekly applications of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate for 16-26 weeks. (curehunter.com)
  • On the other hand, PKC activator 12-o-teradecanoyl phorbol-13-acetate enhanced the HSV-1-induced syncytium formation in A431 epidermoid carcinoma cells, suggesting that PKC activation promotes the development of multinucleated giant cells in herpetic muco-cutaneous lesions. (nii.ac.jp)
  • Here, PAD2OE mice were treated with the carcinogen, 9,10-dimethyl-1,2-benzanthracene and with O -tetradecanoylphorbol-13-acetate and then scored for papilloma formation. (springer.com)
  • One week after initiation is 1-2 months before the appearance of benign papillomas that harbor activated Ha-ras oncogenes when the initiated mice are promoted with the tumor promoter phorbol 12-myristate 13-acetate. (elsevier.com)
  • The number of proliferating cells, identified using PCNA stain, per 1,000 epithelial cells counted, in the mammary glands of 8-week-old rats fed 0%, 5% or 10% flaxseed diet in utero or during postnatal period (n=4-5 rats per group). (nih.gov)
  • Characterization of ornithine decarboxylase activies of human breast cancer cells (MCF-7) and spontaneously immortalized human mammary cells (MCF-10). (cdc.gov)
  • Preliminary to our studies of EMF on ODC in human breast cancer cells (MCF-7) and spontaneously immortalized human mammary cells (MCF-10), we attempted to characterize the enzyme's response to a number of common ODC inducers. (cdc.gov)
  • The antineoplastic activity of the antiestrogen 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) was determined in several estrogen-dependent mammary tumor models. (uni-regensburg.de)
  • Tested on the 9,10-dimethyl-1,2-benzanthracene-induced hormone-dependent mammary adenocarcinoma of the Sprague-Dawley rat all compounds showed marked inhibition of tumor growth. (uni-regensburg.de)
  • For example, sulforaphane was shown to offer statistically significant protection against 9,10-dimethyl-1,2-benzanthracene-induced mammary tumorigenesis in rats (15) . (aacrjournals.org)
  • L-SFN or synthetic SFN offered protection against 9,10-dimethyl-1,2-benzanthracene-induced mammary cancer in rats, azoxymethane-induced colonic aberrant crypt foci in rats, and benzo( a )pyrene-induced forestomach cancer in mice ( 9 - 11 ). (aacrjournals.org)
  • In addition, BALB/c and C57BL/6 females were treated with progesterone or MPA for 1 or 2 months, and mammary glands were excised for histologic studies and for immunohistochemical and Western blot evaluation of ER and PR. (biomedcentral.com)
  • Cherrington BD, Morency E, Struble AM, Coonrod SA, Wakshlag JJ (2010) Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones. (springer.com)
  • Our data indicated that both in utero and postnatal 5% and 10% flaxseed exposures shortened mammary tumor latency, and 10% flaxseed exposure increased tumor multiplicity, compared to the controls. (nih.gov)
  • ER-α protein expression, determined by immunohistochemistry, in the mammary glands of 8-week-old rats exposed to a 0%, 5% or 10% flaxseed diet in utero or during postnatal period (n=4-5 rats per group). (nih.gov)
  • In addition, our gene expression study showed PE-mediated upregulation of Bad, caspase-3, caspase-7, caspase-9, poly (ADP ribose) polymerase and cytochrome c in mammary tumors. (omeka.net)
  • 2.2 Toxicological studies 2.2.1 Special studies on embryotoxicity 2.2.1.1 Rats The embryotoxicity of diminazene dissolved in distilled water was studied in mated female Wistar rats. (inchem.org)
  • 1977). In another study, doses of 2 or 20 mg/kg bw of 14 C-ring- labelled tolylfluanid were orally administered to male and female Wistar rats. (inchem.org)
  • A group of rats of both sexes were also pretreated for 14 days with daily doses of 2 mg/kg bw of non-radioactive tolylfluanid before receiving the radioactive compound. (inchem.org)
  • Biotransformation A single dose of fluorodichloromethyl- 14 C-labelled tolylfluanid was administered orally or intravenously to rats (5 or 10 mg/kg bw). (inchem.org)
  • The main radioactive metabolite in the urine of treated rats was found to be thiazolidine-2-thione-4-carbonic acid (TTC). (inchem.org)
  • 1. The effects of frozen irradiated homogenous bone grafts on the healing of circumscribed defects in the mandibles and femora of forty albino rats have been studied. (wits.ac.za)
  • Further, when assessed in 8-week-old rats, in utero 10% flaxseed exposure increased lobular ER-alpha protein levels, and both in utero and postnatal flaxseed exposures dose-dependently reduced ER-beta protein levels in the terminal end buds (TEBs) lobules and ducts. (nih.gov)
  • Rats exposed to 10% flaxseed in utero exhibited elevated, and rats exposed to 5% flaxseed during postnatal period reduced expression of this receptor. (nih.gov)
  • Rats received either TMX or estradiol benzoate (E 2 B) for 3 or 7 days. (elsevier.com)
  • 3 H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)- butyl)benzamide: A selective radioligand for dopamine D 3 receptors. (unthsc.edu)
  • To identify possible genetic changes associated with the development of malignant tumors, explanted cells were cultured En vitro and assessed for karyotypic changes between the second and third passages by analyzing G-banded metaphase chromosomes. (elsevier.com)
  • Multiple skin tumors in mice following a single painting with 9:10 dimethyl-1:2 benzanthracene. (docphin.com)
  • An inhalation slope factor of 6.1 (mg/kg/day) -1 (U.S. EPA, 1992b) was calculated for benzo[ a ]pyrene based on the incidence of respiratory tumors in golden hamsters treated with benzo[ a ]pyrene (Thyssen et al. (ornl.gov)
  • Eradication of transplanted leukemia in mice and attempts at inhibition of other manifest malignant tumors in mice by treatment with 9 : 10-dimethyl- 1 : 2-benzanthracene. (le-jasmin-briancon.com)
  • Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal fibroblasts isolated from Spalax possess tumor-suppressive activity. (nih.gov)
  • Evidence that tumorigenesis is a multistage process first emerged from experiments showing that wounding of skin previously treated with coal tar resulted in tumor formation at the wound site (1). (springer.com)
  • 1949. The persistence of latent tumor cells induced in the mouse's skin by a single application of 9,10-dimethyl-1-2-benzanthracene. (springer.com)
  • In future, we will test the inhibitory effect of above described PK inhibitors on both HSV-1 and tumor formation in vivo. (nii.ac.jp)
  • Interestingly, most of the genetically modified mice available for the study of breast cancer do not express ER and PR [ 2 ], leaving few models available in which to address hormone-dependent tumor progression specifically. (biomedcentral.com)
  • Multiple in vitro and in vivo studies have shown that curcumin exerts anticancer activities in many cancer cell lines and tumor models targeting multiple signaling pathways including Notch1 ( 6 ), COX-2 ( 7 ), chk1 ( 8 ), NF-κB ( 9, 10 ), SP1 ( 9 ), and Stat3 ( 11 ). (aacrjournals.org)
  • To assess the effects of single polycyclic aromatic hydrocarbons (PAHs) on solid tumor initiation, and investigate their roles in immune response () were randomly divided into 5 groups (n=20) to be intraperitoneally injected with 10 Cited by: Histopathological analysis of mice. (le-jasmin-briancon.com)
  • Mice are challenged with herpes simplex virus-2 (HSV-2) to determine the correlation of tissue damage as quantified by OCT to increased susceptibility. (spiedigitallibrary.org)
  • A separate group of mice are treated similarly then challenged with HSV-2. (spiedigitallibrary.org)
  • Female SENCAR mice were fed 1 of 3 15% fat diets containing LA at levels of 0.8,4.5, and 8.4% before, during, and after intragastric administration of 6 mg (1 mg/week) 7,12-dimethylbenz(a)anthnicene. (uthscsa.edu)
  • 2. The composition according to claim 1, wherein the disease or condition which is treatable, preventable, or ameliorable by the activation of transcription factor Nrf2 is oxidative stress, detoxification of xenobiotic substances, chronic inflammation, or a disease or condition related thereto. (freepatentsonline.com)
  • Melatonin induced ODC activity significantly in MCF-7 cells with 1 nM concentration at 12h. (cdc.gov)
  • According to the "hit-and-run" model, the presence of the virus is only required to initiate events leading to the transformation of infected cells ( 1 ). (asm.org)
  • The growth of estrogen receptor-positive MCF-7 breast cancer cells was inhibited by the hydroxy derivative D 15414 (10(-8)-10(-5) M). Because of the high binding affinity of D 15414 for the estrogen receptor (RBA 6.7-10.0) and the lack of activity against hormone-independent MDA-MB 231 breast cancer cells, a specific mode of action involving the estrogen receptor is likely. (uni-regensburg.de)
  • Depletion of CENP-E from cultured human cells using antisense oligonucleotides or RNAi causes prolonged cell-cycle delay in mitosis that is characterized by an intact bipolar mitotic spindle with several chromosomes clustered close to either spindle pole ( 10 , 11 ). (pnas.org)
  • 4. The composition according to claim 1, for use in the prevention or suppression of metastasis or infiltration of cancer cells. (freepatentsonline.com)
  • We now show that SFN treatment causes transcriptional repression of androgen receptor (AR) in LNCaP and C4-2 human prostate cancer cells at pharmacologic concentrations. (aacrjournals.org)
  • Exposure of LNCaP and C4-2 cells to SFN resulted in a concentration-dependent and time-dependent decrease in protein levels of total AR as well as Ser 210/213 -phosphorylated AR. (aacrjournals.org)
  • L-SFN was shown to cause transcriptional induction of phase 2 enzymes in prostate cancer cells ( 8 ). (aacrjournals.org)
  • For example, we have reported a novel mechanism for SFN-induced G 2 -M phase cell cycle arrest in cultured prostate cancer cells involving checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C, leading to its sequestration in the cytosol ( 15 ). (aacrjournals.org)
  • MCP-1/CCL2 (monocyte chemoattractant protein-1/CC chemokine ligand 2) is a β or CC chemokine that is expressed by a variety of cell types, including fibroblasts, endothelial, smooth muscle, and glial cells. (elsevier.com)
  • Effect of 9,10-dimethyl-1,2-benzanthracene on the growth of hamster dermal fibroblasts in primary culture. (bvsalud.org)
  • PKC inhibitor H-7 also inhibited the replication of HSV-1. (nii.ac.jp)
  • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. (springer.com)
  • Food and Chemical Toxicology , 45 (10), 1868-1872. (elsevier.com)
  • 5. The composition according to claim 1, for use in the treatment, prevention, or amelioration of inflammation of the arterial wall which leads to arteriosclerosis. (freepatentsonline.com)
  • The starting component 2,3-epoxypropyl neodecanoate, which is mutagenic in vitro , and in vivo , as has been shown in bacterial mutagenicity tests and in an in vivo somatic cell test, is classified as mutagenic Cat. (europa.eu)
  • The mutagenic effect in the in vitro bacterial mutagenicity test is induced by not reacted 2,3-epoxypropyl neodecanoate, which is mutagenic in vitro. (europa.eu)
  • Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). (curehunter.com)
  • All of the compounds, except the 9,10-dim ethyl derivative, exhibit dim er emission at higher concentrations. (royalsocietypublishing.org)
  • Cancer risk reduction using pharmacologic agents, although proven to work, are not generally accepted ( 1 ), and consideration of natural bioactive compounds from dietary sources has emerged as an attractive chemopreventive strategy as these sources have played an important role in the discovery and development of novel chemopreventive agents ( 2, 3 ). (aacrjournals.org)
  • 1. A composition for use in the treatment, prevention or amelioration of a disease or condition which is treatable, preventable, or ameliorable by activation of transcription factor Nrf2 (NF-E2 related factor 2), comprising isohumulones or isomerized hop extract as an active ingredient. (freepatentsonline.com)
  • The induction of phase 2 carcinogen-inactivating enzymes is an important mechanism in the prevention of chemically induced cancers by SFN ( 5 , 6 ). (aacrjournals.org)
  • International Journal of Molecular Medicine , 20 (1), 129-136. (elsevier.com)
  • Journal of Clinical Biochemistry and Nutrition , 2 (1), 41-53. (elsevier.com)
  • Figure 2 shows the results relative to the histopathological analysis of the lung, kidney and urinary bladder in terms of incidence, and provides examples of histopathological appearance of the lesions are shown next to each graph. (le-jasmin-briancon.com)
  • Observations have been made of the concentration dependence of the fluorescence spectra of solutions of 1:2-benzanthracene and fifteen of its hydrocarbon derivatives. (royalsocietypublishing.org)
  • 12. The composition according to claim 9, wherein the food is a health food, functional food, food for specified health use, nutrition supplement food, food claiming to reduce disease risk, and food for patients. (freepatentsonline.com)
  • This Skin Notation Profile provides the SK assignment and supportive data for phe- nol (CAS No. 108-95-2). (cdc.gov)
  • AS hepatic damage was shown to protect the adrenal glands against necrosis it appears that the metabolic conversion of 9;10-dimethyl-1;2-benzanthracene to an adrenolytic derivative is a function of the liver. (gla.ac.uk)
  • Proceedings of the Eighty-Ninth Annual Meeting of the American Association for Cancer Research, March 28 - April 1, 1998, New Orleans, Louisiana. (cdc.gov)
  • Cancer Research , 52 (9), 2489-2496. (edu.au)
  • Microinjection of antibody directed against CENP-E ( 13 , 14 ) and expression of N-terminal deletion mutants of CENP-E lacking 800 or more N-terminal residues, including the motor domain ( 9 , 13 ), produced a similar failure of the minority of chromosomes to achieve metaphase alignment. (pnas.org)
  • Lesser concentrations were found in perirenal fat, brain, gonads and thyroid (3 to 9 times less than the mean body concentration). (inchem.org)
  • PgR concentration increased after 3 days of either E 2 B or TMX administration, but decreased when treatment was prolonged to 7 days. (elsevier.com)
  • In the human body, around 60% of zinc is present in muscles, 30% in bones, and the remaining 10% in skin, hair, pancreas, kidneys and plasma. (mdpi.com)
  • 3. The composition according to claim 2, wherein the disease or condition is cerebral nerve degenerative disease, eye disease, skin disease, asthma, or a disease or condition related thereto. (freepatentsonline.com)
  • Interestingly, sulforaphane treatment also caused a dose- and time-dependent increase in the protein level of Apaf-1 in wild-type, Bax −/− , and Bak −/− MEFs but not in double knockout, suggesting that Bax and Bak might regulate sulforaphane-mediated induction of Apaf-1 protein. (aacrjournals.org)
  • Observational studies suggest that dietary intake of cruciferous vegetables may be inversely associated with the risk of different malignancies, including cancer of the prostate ( 1 - 4 ). (aacrjournals.org)
  • HVS-induced T-cell lymphomas uniformly retain viral genome ( 10 ). (asm.org)
  • The primary ginsenosides and their metabolic cousins have a steroid-like structure (2-3) and are generated by acid hydrolysis of saponins (4) and human intestinal bacteria. (kanker-actueel.nl)
  • Methods in molecular biology (Clifton, N.J.). 627 , p. 91-100 10 p. (unthsc.edu)
  • 1% of the mutagenic substance 2,3-epoxypropyl neodecanoate. (europa.eu)