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FAQ8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Tetrahydronaphthalenes: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Receptors, Serotonin, 5-HT1: A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.Serotonin 5-HT1 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Receptor, Serotonin, 5-HT1A: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.Serotonin 5-HT1 Receptor Antagonists: Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.5,7-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.Raphe Nuclei: Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.Dioxanes: 1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)2,5-Dimethoxy-4-Methylamphetamine: A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.PiperazinesBiodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Receptors, Dopamine D3: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Amphetamines: Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.Methoxydimethyltryptamines: Compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups. Members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains. They are possibly involved in the etiology of schizophrenia.Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Serotonin Uptake Inhibitors: Compounds that specifically inhibit the reuptake of serotonin in the brain.Serotonin 5-HT2 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT2 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT2 receptor subtypes.Corynebacterium: A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.Dopamine Agonists: Drugs that bind to and activate dopamine receptors.Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.Methysergide: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.Arthrobacter: A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Dopamine Antagonists: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Hydroxyindoleacetic AcidReceptor, Serotonin, 5-HT2A: A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.Injections, Intraventricular: Injections into the cerebral ventricles.Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Rhodococcus: A bacterial genus of the order ACTINOMYCETALES.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Defective Viruses: Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.Body Temperature: The measure of the level of heat of a human or animal.Microdialysis: A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Behavior, Animal: The observable response an animal makes to any situation.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Autoradiography: The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Viral Interference: A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
5-HT receptor
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Winstanley CA, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 36 (2): 233-9. doi:10.1016/S0028-3908(96)00171-2. PMID 9144661. Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL ...
5-HT1A receptor
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Oshima T, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 3.0.CO;2-D. PMID 9754630. Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer ...
8-OH-DPAT
... di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular ... di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin. 15 (4): 377-84. doi:10.1016/0361-9230(85)90005-X. PMID ... di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ...
5-Methoxytryptamine
... di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine". Neurosci. Lett. 86 (1): 72-76. doi:10.1016/0304-3940( ... 318 (2-3): 403-409. doi:10.1016/S0014-2999(96)00777-7. PMID 9016931. Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, ... 323 (2-3): 235-240. doi:10.1016/S0014-2999(97)00029-0. PMID 9128844. Amemiya N, Hatta S, Takemura H, Ohshika H (1996). " ... ISBN 978-1-58829-568-2. S. Nigra / Domenech T, et al., 1997 Cortex / PEROUTKA ET AL., 1989 Cloned / ZGOMBICK JM, ET AL., 1992 ...
7-OH-DPAT
... di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist". Journal of Medicinal ... hydroxy-N,N-di-n-propyl-2-aminotetralin". Proceedings of the National Academy of Sciences of the United States of America. 89 ( ... "7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for ... N-dipropyl-7-hydroxy-2-aminotetralin". Naunyn-Schmiedeberg's Archives of Pharmacology. 336 (5): 494-501. doi:10.1007/bf00169305 ...
List of MeSH codes (D04)
... di-n-propylamino)tetralin MeSH D04.615.638.960.492 --- levobunolol MeSH D04.615.638.960.585 --- mibefradil MeSH D04.615.638.960 ... vitamin k 2 MeSH D04.615.638.721.374.922 --- vitamin k 3 MeSH D04.615.638.845 --- 1-naphthylamine MeSH D04.615.638.845.800 --- ... 8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide MeSH D04.615.885.120 --- buspirone MeSH D04.615.885.345 --- fluorescamine MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 --- fusidic acid MeSH D04.808.247.808.607 --- lanosterol MeSH D04.808.247.808. ...
5-OH-DPAT
... di-n-propylamino)tetralin in rodents and nonhuman primate". Synapse (New York, N.Y.). 37 (1): 64-70. doi:10.1002/(SICI)1098- ... Karlsson A, Björk L, Pettersson C, Andén NE, Hacksell U (1990). "(R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): ... dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation". Journal ... "5-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for ...
Impaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) Receptors
... di-n-propylamino)tetralin (R-8-OH-DPAT; 30 nM) was routinarily tested and neurons in which firing was not abolished (n. =. 2) ... Annu Rev Pathol Mech Dis 4: 517-550 [PMC free article] [PubMed] ... 0.11; 3% CO2, p. =. 0.11) and Htr1aRO (9% CO2, p. =. 0.35; 3% ... Ente Cassa di Risparmio diFirenze(2007-0758), European Commission (FP7-DEVANX, C.T.G.) and EMBL (E.A. and C.T.G.). The funders ... Figure 2. In the absence of α1-adrenoceptor stimulation, 9% CO2 does not change firing rate of spontaneously active ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3441566/?lang=en-ca
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
... di-n-propylamino)tetralin, (-)- View Synonyms. View Structure. Detailed Summary. * Info Biological activities and chemical ...
https://druginfo.nlm.nih.gov/drugportal/rn/80300-10-3
Plus it
... di-n-propylamino)tetralin). DA. dopamine. DS. discriminative stimulus. NE. norepinephrine. FR. fixed ratio. FRF. sum of the ... di-n-propylamino)tetralin) did not enhance the DS effects of cocaine. Analysis of the relationship between behavioral andin ... 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine). HDL. high-dose lever. MW. molecular weight. NE. norepinephrine. ... 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine. VTA. ventral tegmental area. ...
http://jpet.aspetjournals.org/content/284/3/1015
The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.
... di-n-propylamino)tetralin. A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. ... After successful resuscitation, animals were randomized to receive ABS 201 (8 mg/kg/h) or placebo. Postresuscitation myocardial ...
https://www.bioportfolio.com/resources/pmarticle/2345873/The-Effects-of-Pharmacological-Hypothermia-Induced-by-Neurotensin-Receptor-Agonist-ABS-201.html Plus it
... di-n-propylamino)tetralin Challenge. Rats (n = 48) in the 5-HT1A experiment received the same regimen of adolescent MDMA or ... di-n-propylamino)tetralin; AUC, area under the curve; WAY-100635, [3H]N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- ... di-n-propylamino)tetralin (8-OH-DPAT; Sigma Chemical, St. Louis, MO) or saline (s.c.). Animals were placed into clear glass ... di-n-propylamino)tetralin (8-OH-DPAT) (0.1 or 0.5 mg/kg). Adolescent MDMA exposure partially attenuated the hyperthermic ...
http://jpet.aspetjournals.org/content/317/2/838 8-OH-DPAT - Википедија, слободна енциклопедија
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... Aminoindani: 5-IAI • AMMI • ETAI • MDAI • MDMAI • MMAI • TAI; Aminotetralini: 6-CAT • 8-OH-DPAT • MDAT • MDMAT; Oksazolini: 4- ...
https://sr.wikipedia.org/wiki/8-OH-DPAT
5-HT1A Receptors in Anxiety | SpringerLink
2 AND 3; Peroutka, 1988), among which the 5-HT1Asubtype has been the focus of intense research during the last... ... di-N-propylamino)tetralin, a selective serotonin1A receptor agonist. Psychopharmacology, 94, 84-91.PubMedCrossRefGoogle Scholar ... di-n-propylamino)tetralin, a selective serotonin1A receptor agonist. Eur. J. Pharmacol., 144, 223-9.PubMedCrossRefGoogle ... di-n-propylamino)tetralin (8-OH-DPAT). Eur. J. Pharmacol., 105, 365-8.PubMedCrossRefGoogle Scholar ...
https://link.springer.com/chapter/10.1007/978-1-349-11847-2_7
Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake.
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an actio.... 11786239 - The effect of naloxone on operant ... 8402149 - Predator-induced opioid and non-opioid mediated analgesia in young meadow voles: sex di.... 21576929 - Hypothalamic ... Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, ... Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob ...
http://www.biomedsearch.com/nih/Regulatory-effects-Y4-receptor-agonist/20600429.html
5-HT1A receptor - wikidoc
... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. PMID 8013549. doi:10.1016/0014-2999(94)90756-0.. ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. PMID 7862892. doi: ... 290 (2): R405-13. PMID 16166206. doi:10.1152/ajpregu.00440.2005.. *↑ 57.0 57.1 Van de Kar LD, Levy AD, Li Q, Brownfield MS ( ...
http://wikidoc.org/index.php/5-HT1A_receptor
KAKEN - Research Projects | 下行性の筋緊張制御における脊髄のセロトニン1Aおよび2受
... di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.'Eur.J.Pharmacol.. 373. 171-179 (1999). *. Related Report. ... di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.'Eur.J.Pharmacol.. 373. 171-179 (1999). *. Description. 「研究 ... di-n-propylaminc)tetrdlin on the monosynaptic spinal reflex in rats'Eur. J. Pharmacol.. 373. 171-179 (1999). *. Description. 「研 ... 2.We showed that cyclobenzaprine, and amitriptyline and cyproheptadine, analogs of cyclobenzaprine blocked the 5-HT2 receptors ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672258/
Tryptophan, serotonin, and aging
... di-n-propylamino) tetralin (8-OH-DPAT; 0.15 mg/kg) impaired rats' rapid visual learning on a computerized maze. This treatment ... Whereas the inverse process occurs during lipolysis; i.e. an increase in the proportion of the acids in the 2 position. In the ... In the presence of ionomycin and either 1,2-dioctanoylglycerol or phorbol 12-myristate 13-acetate, the release of serotonin ... The last of 8 rats surviving the period of tryptophan-deficiency died at 45.50 months (1387 days) while the last of 14 control ...
http://raypeat.com/articles/aging/tryptophan-serotonin-aging.shtml The Discriminative Stimulus Properties of Hallucinogenic and Dissociative Anesthetic Drugs | SpringerLink
... di-n-propylamino)tetralin. Pharmacol Biochem Behav 66:483-488CrossRefPubMedGoogle Scholar ... Di Benedetto M, Bastias Candia Sdel C, D'Addario C, Porticella EE, Cavina C, Candeletti S et al (2011) Regulation of opioid ... 2.. Sami M, Piggott K, Coysh C, Fialho A (2015) Psychosis, psychedelic substance misuse and head injury: a case report and 23 ... 8.. Fiorella D, Rabin RA, Winter JC (1995) Role of 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs ...
https://link.springer.com/chapter/10.1007%2F7854_2016_29
Plus it
... di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- ... di-n-propylamino)-tetralin; N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane-carboxamide] and an ... Todd AJ, Hughes DI, Polgar E, Nagy GG, Mackie M, Ottersen OP, Maxwell DJ (2003) The expression of vesicular glutamate ... Effects of 2-Me 5-HT. A, B, Time course and mean depression evoked by 2-Me 5-HT as in Figure 3, A and B. The plots are based on ...
http://www.jneurosci.org/content/25/3/584 Food, Food Allergies, and Nutrition sub-cluster 68
... di-n-propylamino)-tetralin (8-OH-DPAT) on food intake were investigated in food-deprived rats. 8-OH-DPAT (25-100 microg/kg) ... 5-hydroxy-indole-acetic acid ... ... di-n-propylamino)-tetralin (8-OH-DPAT) on food intake in non- ... di-n-propylamino)-tetralin (8-OH-DPAT) were investigated on food intake in non-deprived mice. 8-OH-DPAT (50-200 mg/kg) ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A ... ...
http://www.biomedsearch.com/cluster/49/Food-Food-Allergies-and-Nutrition/sub-68-p9.html 5-HT1A receptor - Wikipedia
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Oshima T, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 3.0.CO;2-D. PMID 9754630. Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer ...
https://en.wikipedia.org/wiki/5-HT1A_receptor 8-OH-DPAT - Wikipedia
... di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular ... di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin. 15 (4): 377-84. doi:10.1016/0361-9230(85)90005-X. PMID ... di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ...
https://en.wikipedia.org/wiki/8-OH-DPAT
CiNii 論文 -
セロトニン再取り込み阻害薬 (fluoxetine) 慢性投与後の
... di-n-propylamino) tetralin(8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats WADA Y ... 2. Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system : single cell studies in the rat ... 脳波と筋電図 : Japanese journal of electroencephalography and electromyography 23(2), 258-264, 1995-04-30 ...
http://ci.nii.ac.jp/naid/10008473118 Plus it
... di-n-propylamino)tetralin. These results indicate that Adcyap1−/− mice act as a model of hyperlocomotion and PPI deficits and ... di-n-propylamino)tetralin (8-OH-DPAT) or buspirone significantly decreased rectal temperature in wild-type mice, whereas the ... A-D, Locomotor activity in wild-type (A, C) and Adcyap1−/− (B, D) mice that received 0.05 mg/kg 8-OH-DPAT (triangles), 0.3 mg/ ... Figure 2. A-C, Number of jumps in Adcyap1−/− mice after pretreatment with haloperidol (A), amphetamine (B), and methylphenidate ...
http://www.jneurosci.org/content/26/19/5091
Atividade serotoninérgica perinatal: um fator decisivo para o controle da ingestão alimentar
... di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons. Eur J ... Am J Dis Child. 1970;120(5):411. [ Links ] 9 Morgane P, Miller M, Kemper T, Stern W, Forbes W, Hall R, et al. The effects of ... 1992;68(2):175-81. [ Links ] 25 Wallace JA, Lauder JM. Development of the serotonergic system in the rat embryo: An ... 2 Manjarrez G, Chagoya G, Hernández R J. Early nutritional changes modify the kinetics and phosphorylation capacity of ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732017000400535&lng=pt&nrm=iso&tlng=en
Involvement of serotonin1A receptors in cardiovascular responses to stress: a radio-telemetry study in four rat strains
... di-n-propylamino)tetralin (MeSH) * Animals (MeSH) * Behavioral Science & Comparative Psychology (Science Metrix) ... 8-OH-DPAT treatment reduced the blood pressure increase in FH rats and WKY rats, but had no effect in SHR and enhanced the ... We studied the effect of treatment with the serotonin-1A (5-HT1A) receptor ligands buspirone, 8-hydroxy-di-propyl-aminotetralin ... 8-azaspiro[4,5]decane-7,9-dione methyl sulphonate (MDL73,005EF) on blood pressure and heart rate increases to open field stress ...
https://scholars.latrobe.edu.au/display/publication24469
- Publications] M.Honda and H.Ono: 'Differential effects of (R)-and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats. (nii.ac.jp)
- 8-OH-DPAT treatment reduced the blood pressure increase in FH rats and WKY rats, but had no effect in SHR and enhanced the pressor response in SD rats. (edu.au)
- Increasing doses of the 5-HT(1A) receptor agonist 8-OH-DPAT caused disruption of PPI, with the effect being significantly greater in FH rats compared to WKY rats. (edu.au)
- Dorsal raphe lesions abolish effects of 8-OH-DPAT and ipsapirone in the X-maze. (springer.com)
- Paroxetine, in combination with WAY 100635, attenuated the hypothermic effects of 8-OH-DPAT as early as 3 days, with a full reversal evident following 7 days, whereas paroxetine, although attenuating the hypothermic effects in OB group by day 7, only reversed it fully after 14 days. (austin.org.au)
- The ability of the combination group to attenuate the hypothermic effects of 8-OH-DPAT faster than paroxetine alone, further emphasizes the role of the 5-HT1A receptor in the mechanism of action of antidepressants, and as a target for the development of faster acting antidepressants. (austin.org.au)
- All the monoamine reuptake blockers produced high-dose-appropriate responding in a dose-related manner when combined with a low dose of cocaine, but compounds from other pharmacological classes (benztropine, caffeine, diazepam, or 8-hydroxy-2-(di-n-propylamino)tetralin) did not enhance the DS effects of cocaine. (aspetjournals.org)
- In the mice fed with a normal diet, the cumulative food intake significantly decreased at 20 min and 1 h after the administration of 1 mg/kg of BVD-74D and at 1, 2, 4, 8, and 24 h after the administration of 10 mg/kg of BVD-74D. (biomedsearch.com)
- Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, and 4 h after BVD-74D (10 mg/kg) administration. (biomedsearch.com)
- Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob/ob mice. (biomedsearch.com)
- In all strains, treatment with 0.5 mg/kg of 8-OH-DPAT significantly reduced PPI. (edu.au)
- A single dose of 8-OH-DPAT reduces raphe binding of [ 3 H]8-OH-DPAT and increases the effect of raphe stimulation on 5-HT metabolism. (springer.com)
- A) Effect of 8-OH-DPAT on [ 35 S]-GTPγS binding to Sprague-Dawley rat brainstem membranes in the presence of DMSO or 100 nM THCV ( n = 11). (nih.gov)
- D) Effect of 8-OH-DPAT on [ 35 S]GTPγS binding to human 5-HT 1 A CHO cell membranes in the presence of DMSO (vehicle) or 100 nM THCV ( n = 8). (nih.gov)
- For the construction of log concentration-response curves, β,γ-methylene ATP was first added 30 min (A) after DMSO or 100 nM cannabigerol ( n = 6 or 8) or (B) after DMSO or 1 µM cannabigerol ( n = 8). (nih.gov)
- Austin Health Research Online: Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. (austin.org.au)
- [8] Vasodilation of the blood vessels in the skin via central 5-HT 1A activation increases heat dissipation from the organism out into the environment, causing a decrease in body temperature . (wikidoc.org)
- N -(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride] were investigated on dorsal horn interneurons mediating reflex actions of group II muscle afferents. (jneurosci.org)
- In vitro bactericidal activity of human beta-defensin 2 against nosocomial strains. (biomedsearch.com)
- B) Effect of 8-OH-DPAT ( n = 4) and THCV ( n = 6) on [ 35 S]-GTPγS binding to Sprague-Dawley rat brainstem membranes. (nih.gov)
- E) Effect of 8-OH-DPAT ( n = 9) and THCV ( n = 10) on [ 35 S]GTPγS binding to human 5-HT 1 A CHO cell membranes. (nih.gov)
- 8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. (wikipedia.org)
- We found wide homogeneous distribution of firing rates, well fitted by a single Gaussian function ( r 2 = 0.93) and independent of anatomical location ( P = 0.45), suggesting that in terms of intrinsic firing properties, serotonergic neurons in the DRN represent a single cellular population. (frontiersin.org)