AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
8-Hydroxy-2-(di-n-propylamino)tetralinTetrahydronaphthalenesSerotonin Receptor AgonistsReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin 5-HT1 Receptor AgonistsSerotonin AntagonistsBuspironeSphingomonasReceptor, Serotonin, 5-HT1ASerotoninKetanserinSerotonin 5-HT1 Receptor AntagonistsMethiothepinSpiperone5,7-DihydroxytryptamineRaphe NucleiDioxanes2,5-Dimethoxy-4-MethylamphetaminePiperazinesBiodegradation, EnvironmentalReceptors, Dopamine D3NaphthalenesAmphetaminesMethoxydimethyltryptaminesPindololSerotonin Uptake InhibitorsSerotonin 5-HT2 Receptor AgonistsCorynebacteriumFluoxetineDopamine AgonistsFenfluramineMethysergideArthrobacterSpiro CompoundsDopamine AntagonistsRats, Sprague-DawleyHydroxyindoleacetic AcidReceptor, Serotonin, 5-HT2AInjections, IntraventricularPyridinesRhodococcusDose-Response Relationship, DrugDefective VirusesBody TemperatureMicrodialysisReceptors, Dopamine D2Anti-Anxiety AgentsDiethylhexyl PhthalateOxygenasesBehavior, AnimalRats, WistarBrain ChemistryCarcinogenicity TestsSolventsDrug InteractionsOperonAutoradiographyRats, Inbred StrainsViral InterferenceNeuronsSpinal CordMotor ActivityMolecular Sequence Data
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Tetrahydronaphthalenes: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Receptors, Serotonin, 5-HT1: A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.Serotonin 5-HT1 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Receptor, Serotonin, 5-HT1A: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.Serotonin 5-HT1 Receptor Antagonists: Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.5,7-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.Raphe Nuclei: Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.Dioxanes: 1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)2,5-Dimethoxy-4-Methylamphetamine: A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.PiperazinesBiodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Receptors, Dopamine D3: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Amphetamines: Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.Methoxydimethyltryptamines: Compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups. Members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains. They are possibly involved in the etiology of schizophrenia.Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Serotonin Uptake Inhibitors: Compounds that specifically inhibit the reuptake of serotonin in the brain.Serotonin 5-HT2 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT2 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT2 receptor subtypes.Corynebacterium: A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.Dopamine Agonists: Drugs that bind to and activate dopamine receptors.Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.Methysergide: An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.Arthrobacter: A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Dopamine Antagonists: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Hydroxyindoleacetic AcidReceptor, Serotonin, 5-HT2A: A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.Injections, Intraventricular: Injections into the cerebral ventricles.Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Rhodococcus: A bacterial genus of the order ACTINOMYCETALES.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Defective Viruses: Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.Body Temperature: The measure of the level of heat of a human or animal.Microdialysis: A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Behavior, Animal: The observable response an animal makes to any situation.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Autoradiography: The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Viral Interference: A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
8-Hydroxy-2-(di-n-propylamino)tetralinTetrahydronaphthalenesSerotonin Receptor AgonistsReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin 5-HT1 Receptor AgonistsSerotonin AntagonistsBuspironeSphingomonasReceptor, Serotonin, 5-HT1ASerotoninKetanserinSerotonin 5-HT1 Receptor AntagonistsMethiothepinSpiperone5,7-DihydroxytryptamineRaphe NucleiDioxanes2,5-Dimethoxy-4-MethylamphetaminePiperazinesBiodegradation, EnvironmentalReceptors, Dopamine D3NaphthalenesAmphetaminesMethoxydimethyltryptaminesPindololSerotonin Uptake InhibitorsSerotonin 5-HT2 Receptor AgonistsCorynebacteriumFluoxetineDopamine AgonistsFenfluramineMethysergideArthrobacterSpiro CompoundsDopamine AntagonistsRats, Sprague-DawleyHydroxyindoleacetic AcidReceptor, Serotonin, 5-HT2AInjections, IntraventricularPyridinesRhodococcusDose-Response Relationship, DrugDefective VirusesBody TemperatureMicrodialysisReceptors, Dopamine D2Anti-Anxiety AgentsDiethylhexyl PhthalateOxygenasesBehavior, AnimalRats, WistarBrain ChemistryCarcinogenicity TestsSolventsDrug InteractionsOperonAutoradiographyRats, Inbred StrainsViral InterferenceNeuronsSpinal CordMotor ActivityMolecular Sequence Data
5-HT1A receptor5-HT1A receptor
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Oshima T, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 3.0.CO;2-D. PMID 9754630. Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer ...
5-HT receptor5-HT receptor
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Winstanley CA, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 36 (2): 233-9. doi:10.1016/S0028-3908(96)00171-2. PMID 9144661. Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL ...
7-OH-DPAT7-OH-DPAT
... di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist". Journal of Medicinal ... hydroxy-N,N-di-n-propyl-2-aminotetralin". Proceedings of the National Academy of Sciences of the United States of America. 89 ( ... "7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for ... N-dipropyl-7-hydroxy-2-aminotetralin". Naunyn-Schmiedeberg's Archives of Pharmacology. 336 (5): 494-501. doi:10.1007/bf00169305 ...
5-Methoxytryptamine5-Methoxytryptamine
... di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine". Neurosci. Lett. 86 (1): 72-76. doi:10.1016/0304-3940( ... 318 (2-3): 403-409. doi:10.1016/S0014-2999(96)00777-7. PMID 9016931. Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, ... 323 (2-3): 235-240. doi:10.1016/S0014-2999(97)00029-0. PMID 9128844. Amemiya N, Hatta S, Takemura H, Ohshika H (1996). " ... ISBN 978-1-58829-568-2. S. Nigra / Domenech T, et al., 1997 Cortex / PEROUTKA ET AL., 1989 Cloned / ZGOMBICK JM, ET AL., 1992 ...
8-OH-DPAT8-OH-DPAT
... di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular ... di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin. 15 (4): 377-84. doi:10.1016/0361-9230(85)90005-X. PMID ... di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ...
List of MeSH codes (D04)List of MeSH codes (D04)
... di-n-propylamino)tetralin MeSH D04.615.638.960.492 --- levobunolol MeSH D04.615.638.960.585 --- mibefradil MeSH D04.615.638.960 ... vitamin k 2 MeSH D04.615.638.721.374.922 --- vitamin k 3 MeSH D04.615.638.845 --- 1-naphthylamine MeSH D04.615.638.845.800 --- ... 8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide MeSH D04.615.885.120 --- buspirone MeSH D04.615.885.345 --- fluorescamine MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 --- fusidic acid MeSH D04.808.247.808.607 --- lanosterol MeSH D04.808.247.808. ...
8-OH-DPAT - Википедија, слободна енциклопедија8-OH-DPAT - Википедија, слободна енциклопедија
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... Aminoindani: 5-IAI • AMMI • ETAI • MDAI • MDMAI • MMAI • TAI; Aminotetralini: 6-CAT • 8-OH-DPAT • MDAT • MDMAT; Oksazolini: 4- ...
5-OH-DPAT5-OH-DPAT
... di-n-propylamino)tetralin in rodents and nonhuman primate". Synapse (New York, N.Y.). 37 (1): 64-70. doi:10.1002/(SICI)1098- ... Karlsson A, Björk L, Pettersson C, Andén NE, Hacksell U (1990). "(R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): ... dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation". Journal ... "5-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for ...
Receptor de serotonina, la enciclopedia libreReceptor de serotonina, la enciclopedia libre
... di-n-propylamino)tetralin.». Eur J Pharmacol. 253 (1-2): 53-60. PMID 8013549. doi:10.1016/0014-2999(94)90756-0. ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake». Psychopharmacology (Berl). 115 (1-2): 173-9. PMID 7862892. doi ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors». Methods Find Exp Clin ... doi:10.1016/S0091-3057(01)00712-2. *↑ a b Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E (2004). «Effects of a ...
SerotoniinireseptoriSerotoniinireseptori
... di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549.. ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology (Berl). 115 (1-2): 173-9. doi:10.1007/ ... Rev. 46 (2): 157-203. PMID 7938165.. *↑ Frazer A, Hensler JG (1999). "Chapter 13: Serotonin Receptors", in Siegel GJ, Agranoff ...
8-OH-DPAT8-OH-DPAT
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... doi:10.1186/1758-2946-2-3. edit. *↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, ...
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
8-Hydroxy-2-(di-n-propylamino)tetralinTetrahydronaphthalenesSerotonin Receptor AgonistsReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin 5-HT1 Receptor AgonistsSerotonin AntagonistsBuspironeSphingomonasReceptor, Serotonin, 5-HT1ASerotoninKetanserinSerotonin 5-HT1 Receptor AntagonistsMethiothepinSpiperone5,7-DihydroxytryptamineRaphe NucleiDioxanes2,5-Dimethoxy-4-MethylamphetaminePiperazinesBiodegradation, EnvironmentalReceptors, Dopamine D3NaphthalenesAmphetaminesMethoxydimethyltryptaminesPindololSerotonin Uptake InhibitorsSerotonin 5-HT2 Receptor AgonistsCorynebacteriumFluoxetineDopamine AgonistsFenfluramineMethysergideArthrobacterSpiro CompoundsDopamine AntagonistsRats, Sprague-DawleyHydroxyindoleacetic AcidReceptor, Serotonin, 5-HT2AInjections, IntraventricularPyridinesRhodococcusDose-Response Relationship, DrugDefective VirusesBody TemperatureMicrodialysisReceptors, Dopamine D2Anti-Anxiety AgentsDiethylhexyl PhthalateOxygenasesBehavior, AnimalRats, WistarBrain ChemistryCarcinogenicity TestsSolventsDrug InteractionsOperonAutoradiographyRats, Inbred StrainsViral InterferenceNeuronsSpinal CordMotor ActivityMolecular Sequence Data
Impaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) ReceptorsImpaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) Receptors
... di-n-propylamino)tetralin (R-8-OH-DPAT; 30 nM) was routinarily tested and neurons in which firing was not abolished (n. =. 2) ... Annu Rev Pathol Mech Dis 4: 517-550 [PMC free article] [PubMed] ... 0.11; 3% CO2, p. =. 0.11) and Htr1aRO (9% CO2, p. =. 0.35; 3% ... Ente Cassa di Risparmio diFirenze(2007-0758), European Commission (FP7-DEVANX, C.T.G.) and EMBL (E.A. and C.T.G.). The funders ... Figure 2. In the absence of α1-adrenoceptor stimulation, 9% CO2 does not change firing rate of spontaneously active ...
pubmedcentralcanada.ca
7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide | Sigma-Aldrich7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide | Sigma-Aldrich
... di-n-propylamino)tetralin hydrobromide; CAS Number: 159795-63-8; Synonym: (±)-2-Dipropylamino-7-hydroxy-1,2,3,4- ... tetrahydronaphthalene hydrobromide, (±)-7-Hydroxy-DPAT hydrobromide, (±)-7-OH-DPAT hydrobromide; Linear Formula: C16H25NO · HBr ... di-n-propylamino)tetralin hydrobromide Synonym: (±)-7-Hydroxy-DPAT hydrobromide, (±)-7-OH-DPAT hydrobromide, (±). -. 2- ... di-n-propylamino)tetralin hydrobromide is a selective D3 dopamine receptor agonist (Kd ,1nM); has much weaker affinity for ...
sigmaaldrich.com
Plus itPlus it
... di-n-propylamino)tetralin Challenge. Rats (n = 48) in the 5-HT1A experiment received the same regimen of adolescent MDMA or ... di-n-propylamino)tetralin; AUC, area under the curve; WAY-100635, [3H]N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- ... di-n-propylamino)tetralin (8-OH-DPAT; Sigma Chemical, St. Louis, MO) or saline (s.c.). Animals were placed into clear glass ... di-n-propylamino)tetralin (8-OH-DPAT) (0.1 or 0.5 mg/kg). Adolescent MDMA exposure partially attenuated the hyperthermic ...
jpet.aspetjournals.org
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug InformationDrug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
... di-n-propylamino)tetralin, (-)- View Synonyms. View Structure. Detailed Summary. * Info Biological activities and chemical ...
druginfo.nlm.nih.gov
Plus itPlus it
... di-n-propylamino)tetralin). DA. dopamine. DS. discriminative stimulus. NE. norepinephrine. FR. fixed ratio. FRF. sum of the ... di-n-propylamino)tetralin) did not enhance the DS effects of cocaine. Analysis of the relationship between behavioral andin ... 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine). HDL. high-dose lever. MW. molecular weight. NE. norepinephrine. ... 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine. VTA. ventral tegmental area. ...
jpet.aspetjournals.org
Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial...Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial...
... di-n-propylamino)tetralin / pharmacology* * Animals * Attention / drug effects* ... The effects of 8-OH-DPAT were blocked by the 5-HT(1A) antagonist WAY 100635, at a dose that itself had no significant effects ... Results: Both 8-OH-DPAT and M100907 selectively enhanced accuracy of target detection. When the stimulus duration was shortened ... Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial ...
pubmed.ncbi.nlm.nih.gov
The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.
... di-n-propylamino)tetralin. A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. ... After successful resuscitation, animals were randomized to receive ABS 201 (8 mg/kg/h) or placebo. Postresuscitation myocardial ...
bioportfolio.com
5-HT1A receptor - Wikipedia5-HT1A receptor - Wikipedia
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Oshima T, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 3.0.CO;2-D. PMID 9754630. Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer ...
en.wikipedia.org
8-OH-DPAT - Wikipedia8-OH-DPAT - Wikipedia
... di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular ... di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin. 15 (4): 377-84. doi:10.1016/0361-9230(85)90005-X. PMID ... di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ...
en.wikipedia.org
Frontiers | Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT...Frontiers | Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT...
... di-n-propylamino)tetralin showed mild sensitization and marked desensitization of 5-HT1A receptors in Tph2-/- mice and Sert-/- ... When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both ... di-n-propylamino)tetralin showed mild sensitization and marked desensitization of 5-HT1A receptors in Tph2 -/- mice and Sert ... When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both ...
frontiersin.org
8-OH-DPAT - Википедија, слободна енциклопедија8-OH-DPAT - Википедија, слободна енциклопедија
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... Aminoindani: 5-IAI • AMMI • ETAI • MDAI • MDMAI • MMAI • TAI; Aminotetralini: 6-CAT • 8-OH-DPAT • MDAT • MDMAT; Oksazolini: 4- ...
sr.wikipedia.org
5-HT1A Receptors in Anxiety | SpringerLink5-HT1A Receptors in Anxiety | SpringerLink
2 AND 3; Peroutka, 1988), among which the 5-HT1Asubtype has been the focus of intense research during the last... ... di-N-propylamino)tetralin, a selective serotonin1A receptor agonist. Psychopharmacology, 94, 84-91.PubMedCrossRefGoogle Scholar ... di-n-propylamino)tetralin, a selective serotonin1A receptor agonist. Eur. J. Pharmacol., 144, 223-9.PubMedCrossRefGoogle ... di-n-propylamino)tetralin (8-OH-DPAT). Eur. J. Pharmacol., 105, 365-8.PubMedCrossRefGoogle Scholar ...
link.springer.com
PDF] Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and...PDF] Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and...
... di-n-propylamino)tetralin (8-OH-DPAT). In conscious, unrestrained rabbits, instrumented for recordings of heart rate, arterial ... Systemically administered 8-OH-DPAT (0.004-0.1 mg/kg) substantially attenuated these responses in a dose-dependent manner. Drug ... microinjection of 8-OH-DPAT (500 nl of 10 mM solution) into the medullary raphe-parapyramidal region caused antitachycardic ... 2 and +15 +/- 3 mmHg, respectively). Lipopolysaccharide injection caused sustained increases in heart rate (from 210 +/- 3 to ...
semanticscholar.org
The Discriminative Stimulus Properties of Hallucinogenic and Dissociative Anesthetic Drugs | SpringerLinkThe Discriminative Stimulus Properties of Hallucinogenic and Dissociative Anesthetic Drugs | SpringerLink
... di-n-propylamino)tetralin. Pharmacol Biochem Behav 66:483-488CrossRefPubMedGoogle Scholar ... Di Benedetto M, Bastias Candia Sdel C, DAddario C, Porticella EE, Cavina C, Candeletti S et al (2011) Regulation of opioid ... 2.. Sami M, Piggott K, Coysh C, Fialho A (2015) Psychosis, psychedelic substance misuse and head injury: a case report and 23 ... 8.. Fiorella D, Rabin RA, Winter JC (1995) Role of 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs ...
link.springer.com
Esen A[au] - PubMed - NCBIEsen A[au] - PubMed - NCBI
... di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model.. Cinar O, Durmus N, Aslan G, Demir O, ... Effects of the dopamine D3 receptor agonist 7-hydroxy-2-( ... 2015 Aug;170(2):409-18. doi: 10.1016/j.ahj.2015.04.025. Epub ... 2.. Comparison of ultrasound-guided transversus abdominis plane block, quadratus lumborum block, and caudal epidural block for ... 2015 Oct;53(8):779. doi: 10.1016/j.bjoms.2015.05.005. Epub 2015 Jun 3. No abstract available. ...
ncbi.nlm.nih.gov
Aida Bairams Research on Caffeine (No Doz) | CureHunterAida Bairam's Research on Caffeine (No Doz) | CureHunter
... di-n-propylamino)tetralin (8-OH-DPAT)IBA 01/2013. ... 2/2009. Enhancement of the breathing frequency response to ... 8/2011. Alteration of carotid body chemoreflexes after neonatal intermittent hypoxia and caffeine treatment in rat pups.. ... 8/2010. Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic ...
curehunter.com
Plus itPlus it
... di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- ... di-n-propylamino)-tetralin; N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane-carboxamide] and an ... Todd AJ, Hughes DI, Polgar E, Nagy GG, Mackie M, Ottersen OP, Maxwell DJ (2003) The expression of vesicular glutamate ... Effects of 2-Me 5-HT. A, B, Time course and mean depression evoked by 2-Me 5-HT as in Figure 3, A and B. The plots are based on ...
jneurosci.org
Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake.Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake.
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an actio.... 11786239 - The effect of naloxone on operant ... 8402149 - Predator-induced opioid and non-opioid mediated analgesia in young meadow voles: sex di.... 21576929 - Hypothalamic ... Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, ... Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob ...
biomedsearch.com
Hypertension sub-cluster 20Hypertension sub-cluster 20
... di-n-propylamino) tetralin (8-OH-DPAT) and flesinoxan, agents which show high affinity and selectivity for 5-HT1A receptors, ... The alcoholic group had significantly elevated basal levels of blood pressure and plasma 3-methoxy-4-hydroxy-phenyl glycol. The ... di-n-propylamino) tetralin (8-OH-DPAT) and clonidine in ... ... 2. After clonidine, there was a fall in blood pressure, heart ... 7 8 9 10 11 12 13 14 15 16 17 , 551. Importance of central nervous system serotonin-1A receptors for mediating the hypotensive ...
biomedsearch.com
Plus itPlus it
... di-n-propylamino)tetralin. These results indicate that Adcyap1−/− mice act as a model of hyperlocomotion and PPI deficits and ... di-n-propylamino)tetralin (8-OH-DPAT) or buspirone significantly decreased rectal temperature in wild-type mice, whereas the ... A-D, Locomotor activity in wild-type (A, C) and Adcyap1−/− (B, D) mice that received 0.05 mg/kg 8-OH-DPAT (triangles), 0.3 mg/ ... Figure 2. A-C, Number of jumps in Adcyap1−/− mice after pretreatment with haloperidol (A), amphetamine (B), and methylphenidate ...
jneurosci.org
Tryptophan, serotonin, and agingTryptophan, serotonin, and aging
... di-n-propylamino) tetralin (8-OH-DPAT; 0.15 mg/kg) impaired rats rapid visual learning on a computerized maze. This treatment ... Whereas the inverse process occurs during lipolysis; i.e. an increase in the proportion of the acids in the 2 position. In the ... In the presence of ionomycin and either 1,2-dioctanoylglycerol or phorbol 12-myristate 13-acetate, the release of serotonin ... The last of 8 rats surviving the period of tryptophan-deficiency died at 45.50 months (1387 days) while the last of 14 control ...
raypeat.com
5-HT1A receptor - wikidoc5-HT1A receptor - wikidoc
... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549.. ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 290 (2): R405-13. doi:10.1152/ajpregu.00440.2005. PMID 16166206.. *↑ 57.0 57.1 Van de Kar LD, Levy AD, Li Q, Brownfield MS ( ...
wikidoc.org
KAKEN - Research Projects | 下行性の筋緊張制御における脊髄のセロトニン1Aおよび2受KAKEN - Research Projects | 下行性の筋緊張制御における脊髄のセロトニン1Aおよび2受
... di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.Eur.J.Pharmacol.. 373. 171-179 (1999). *. Related Report. ... di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.Eur.J.Pharmacol.. 373. 171-179 (1999). *. Description. 「研究 ... di-n-propylaminc)tetrdlin on the monosynaptic spinal reflex in ratsEur. J. Pharmacol.. 373. 171-179 (1999). *. Description. 「研 ... 2.We showed that cyclobenzaprine, and amitriptyline and cyproheptadine, analogs of cyclobenzaprine blocked the 5-HT2 receptors ...
kaken.nii.ac.jp
CiNii 論文 - セロトニン再取り込み阻害薬 (fluoxetine) 慢性投与後のCiNii 論文 - セロトニン再取り込み阻害薬 (fluoxetine) 慢性投与後の
... di-n-propylamino) tetralin(8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats WADA Y ... 2. Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system : single cell studies in the rat ... 脳波と筋電図 : Japanese journal of electroencephalography and electromyography 23(2), 258-264, 1995-04-30 ...
ci.nii.ac.jp
Repeated cocaine exposure inhibits the adrenocorticotropic hormone response to the serotonin releaser d-fenfluramine and the 5...Repeated cocaine exposure inhibits the adrenocorticotropic hormone response to the serotonin releaser d-fenfluramine and the 5...
... di-n-propylamino)tetralin * hydroxide ion * Cocaine * Adrenocorticotropic Hormone ... Forty-two hr after the final cocaine injection, the 5-HT releaser d-fenfluramine (0, 0.2, 0.6, 2, or 5 mg/kg, i.p.) or the 5-HT ... Forty-two hr after the final cocaine injection, the 5-HT releaser d-fenfluramine (0, 0.2, 0.6, 2, or 5 mg/kg, i.p.) or the 5- ... Forty-two hr after the final cocaine injection, the 5-HT releaser d-fenfluramine (0, 0.2, 0.6, 2, or 5 mg/kg, i.p.) or the 5- ...
jhu.pure.elsevier.com
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
8-Hydroxy-2-(di-n-propylamino)tetralinTetrahydronaphthalenesSerotonin Receptor AgonistsReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin 5-HT1 Receptor AgonistsSerotonin AntagonistsBuspironeSphingomonasReceptor, Serotonin, 5-HT1ASerotoninKetanserinSerotonin 5-HT1 Receptor AntagonistsMethiothepinSpiperone5,7-DihydroxytryptamineRaphe NucleiDioxanes2,5-Dimethoxy-4-MethylamphetaminePiperazinesBiodegradation, EnvironmentalReceptors, Dopamine D3NaphthalenesAmphetaminesMethoxydimethyltryptaminesPindololSerotonin Uptake InhibitorsSerotonin 5-HT2 Receptor AgonistsCorynebacteriumFluoxetineDopamine AgonistsFenfluramineMethysergideArthrobacterSpiro CompoundsDopamine AntagonistsRats, Sprague-DawleyHydroxyindoleacetic AcidReceptor, Serotonin, 5-HT2AInjections, IntraventricularPyridinesRhodococcusDose-Response Relationship, DrugDefective VirusesBody TemperatureMicrodialysisReceptors, Dopamine D2Anti-Anxiety AgentsDiethylhexyl PhthalateOxygenasesBehavior, AnimalRats, WistarBrain ChemistryCarcinogenicity TestsSolventsDrug InteractionsOperonAutoradiographyRats, Inbred StrainsViral InterferenceNeuronsSpinal CordMotor ActivityMolecular Sequence Data
AgonistRatsHypothermic responseBuspironeAntagonistReceptorsReceptor agonistsBehaviorPharmacologyEthylAgonistsAnxiolyticHydrochlorideMiceSelectivelyNeuropharmacologySelectiveInhibitoryIpsapironeNeuronsInduceDoseEffectsIncreasesABSTRACTResponsesMembranesGene ExpressionJournalEpubSignificantly reducedInjectionDecrease2019ResultsRespiratoryResponseResearchSpinalTph2Contrast
Agonist30
Rats13
  • Rats received intra-mPFC infusions of either 8-OH-DPAT (10, 30 and 100 ng) or M100907 (30, 100 and 300 ng) according to a Latin square design. (nih.gov)
  • Publications] M.Honda and H.Ono: 'Differential effects of (R)-and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats. (nii.ac.jp)
  • The ACTH responses to d-fenfluramine and 8-OH-DPAT were inhibited in cocaine pretreated rats. (elsevier.com)
  • In contrast the PRL responses to 8-OH-DPAT in animals on the low TRP diet for 1 week and 6 weeks were similar to control rats. (ox.ac.uk)
  • Because FSL rats have increased sensitivity to the hypothermic response to 8-hydroxy-2-(diN-propylamino)tetralin (8-OH-DPAT) , interest in the potential involvement of the 5-HT1A receptor in their depressive phenotype was sparked. (scirp.org)
  • 8-OH-DPAT treatment reduced the blood pressure increase in FH rats and WKY rats, but had no effect in SHR and enhanced the pressor response in SD rats. (edu.au)
  • The PE model was established by injection of 8-OH-DPAT in 10 ml normal saline at 0.8 mg per kg of the body weight per day into the subarachnoid space of the lumbosacral spinal cord segments and the control rats were injected with the same volume of normal saline only, both for 4 weeks. (bvsalud.org)
  • At 2 and 4 weeks, the male rats were mated with the female ones for 30 minutes each time and meanwhile observed for their mating behavior indicators, such as mount latency, intromission latency, ejaculation latency, mount frequency, intromission frequency, and ejaculation frequency. (bvsalud.org)
  • IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. (bvsalud.org)
  • 8-OH-DPAT strengthened the ASR in IR but not SOC rats and the drug-reduced PPI could be adjusted by 5,7-DHT pretreatment. (bvsalud.org)
  • 8-OH-DPAT at 100 μg/kg enhanced PPI in 5-HT-depleted SOC rats. (bvsalud.org)
  • However for IR rats, 8-OH-DPAT strengthened PPI in sham rats but downgraded it in depletion condition. (bvsalud.org)
  • and D,L-5-hydroxytryptophan, an immediate precursor) or which can mimic 5-HT (e.g., 5-HT 1 and 5-HT 2 agonists) all significantly decreased the volitional alcohol intake of the high alcohol-seeking rats. (elsevier.com)
Hypothermic response1
Buspirone2
  • These results suggested that berberine at 100 mg/kg had a significant anxiolytic-like effect, which was similar to that observed with 1 mg/kg diazepam and 2 mg/kg buspirone. (longecity.org)
  • We studied the effect of treatment with the serotonin-1A (5-HT1A) receptor ligands buspirone, 8-hydroxy-di-propyl-aminotetralin (8-OH-DPAT), and (8-[2-(2,3-dihydro-1,4-benzodioxin-2-yl-methylamino)ethyl]-8-azaspiro[4,ecane-7,9-dione methyl sulphonate (MDL73,005EF) on blood pressure and heart rate increases to open field stress. (edu.au)
Antagonist7
  • The effects of 8-OH-DPAT were blocked by the 5-HT(1A) antagonist WAY 100635, at a dose that itself had no significant effects on behaviour. (nih.gov)
  • A novel 5-HT 1A receptor antagonist, 4-cyano-N-{2R-[4-(2,3-dihydrobenzo[1,dioxin-5-yl)-piperazin-1- yl]-propyl}-N-pyridin-2-yl-benzamide HCl (lecozotan), which has been characterized in multiple in vitro and in vivo pharmacological assays as a drug to treat cognitive dysfunction, is reported. (elsevier.com)
  • Learning deficits induced by the glutamatergic antagonist MK-801 [(-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate] (assessed by perceptually complex and visual spatial discrimination) and by specific cholinergic lesions of the hippocampus (assessed by visual spatial discrimination) were reversed by lecozotan (2 mg/kg i.m.) in marmosets. (elsevier.com)
  • 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT 1 antagonist, (±)-pindolol, whereas a selective 5-HT 2 antagonist, ritanserin was inactive. (fujita-hu.ac.jp)
  • 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. (fujita-hu.ac.jp)
  • 2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors. (docphin.com)
  • Austin Health Research Online: Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. (austin.org.au)
Receptors12
  • In previous studies, axons possessing 5-HT 3 receptors were found to be excitatory, and as 2-Me 5-HT depressed transmission to dorsal horn interneurons, the results indicate that 5-HT operates at 5-HT 3 receptors presynaptic to these neurons to depress excitatory transmission. (jneurosci.org)
  • 2.We showed that cyclobenzaprine, and amitriptyline and cyproheptadine, analogs of cyclobenzaprine blocked the 5-HT2 receptors in the spinal cord, and consequently depressed the monosynaptic reflexes. (nii.ac.jp)
  • In vitro studies investigated the effect of THCV on targeting by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) of 5-HT₁A receptors in membranes obtained from rat brainstem or human 5-HT₁A CHO cells, using [(35)S]-GTPγS and 8-[(3)H]-OH-DPAT binding assays. (nih.gov)
  • and (iv) at 100 nM, significantly enhanced 8-OH-DPAT-induced activation of these human 5-HT₁A receptors. (nih.gov)
  • Cannabis elicits in humans a complex subjective experience, a combination of mood elevation, heightened sensitivity to external stimuli, and relaxation ( 1 ), which results from the interaction of its main psychoactive constituent, Δ 9 -tetrahydrocannabinol (Δ 9 -THC), with CB 1 cannabinoid receptors in the brain ( 2 ). (pnas.org)
  • There are 14 different serotonin receptors ( 2 ), some of which have multiple splice variants that enable binding of distinct sets of intracellular proteins ( 5 ). (sciencemag.org)
  • Pharmacologic and genetic studies have suggested a role for 5-HT 1B receptors in the pathophysiology of obsessive compulsive disorder, drug addiction, depression, anxiety, aggression, and sleep ( 1 , 7 , 8 ). (sciencemag.org)
  • p11 interacted with 5-HT 1B receptors, but not with 5-HT 1A , 5-HT 2A , 5-HT 5A , 5-HT 6 , dopamine D 1 or D 2 receptors, two irrelevant baits (CΔ115 and pRP21), or the empty plasmid, which showed the specificity of this interaction ( Fig. 1A ). (sciencemag.org)
  • 7,8 These findings confirm that μ-opioid receptors are the key targets for opioid-induced respiratory depression. (asahq.org)
  • Effects on the serotonin system, especially serotonin-2 receptors, may contribute to clozapine's atypicality. (ox.ac.uk)
  • 5-Hydroxytryptamine (5-HT)2 receptors can be partially characterized by their sensitivity to ketanserin blockade and increase in phosphoinositide turnover upon stimulation. (mysciencework.com)
  • Titeler, M. Binding of indolylalkylamines at 5-HT 2 serotonin receptors: Examination of a hydrophobic binding region . (isomerdesign.com)
Receptor agonists2
Behavior2
Pharmacology3
Ethyl2
Agonists2
  • Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists, 8-OH-DPAT and mCPP in the male rat. (ox.ac.uk)
  • The study was undertaken to assess the long term effects of tryptophan (TRP) depletion through diet on the prolactin (PRL) responses to the serotonin (5-hydroxytryptophan, 5-HT) agonists m-chlorophenyl-piperazine (mCPP) and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the male rat. (ox.ac.uk)
Anxiolytic1
  • BER also attenuated the anxiogenic effect of WAY-100635, 8-OH DPAT and DOI and enhanced the anxiolytic effect of BUS, p-MPPI and RIT in the elevated plus-maze. (longecity.org)
Hydrochloride1
  • N -(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride] were investigated on dorsal horn interneurons mediating reflex actions of group II muscle afferents. (jneurosci.org)
Mice10
  • Here, we investigated how persistent alterations in brain 5-HT availability affect autoinhibition in two genetically modified mouse models lacking critical mediators of serotonergic transmission: 5-HT transporter knockout ( Sert -/-) and tryptophan hydroxylase-2 knockout ( Tph2 -/-) mice. (frontiersin.org)
  • When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy- L -tryptophan (5-HTP), neurons from both Tph2 -/- and Sert -/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. (frontiersin.org)
  • In the mice fed with a normal diet, the cumulative food intake significantly decreased at 20 min and 1 h after the administration of 1 mg/kg of BVD-74D and at 1, 2, 4, 8, and 24 h after the administration of 10 mg/kg of BVD-74D. (biomedsearch.com)
  • Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, and 4 h after BVD-74D (10 mg/kg) administration. (biomedsearch.com)
  • Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob/ob mice. (biomedsearch.com)
  • 2002). Recently we have identified a novel arcuate neuronal population in mice, which regulate energy homeostasis, by the expression of green fluorescent protein (GFP) induced by the rat insulin 2 promoter (RipCre) transgene (Choudhury et al. (physoc.org)
  • 2005). Mice (8-16 weeks) were humanely killed. (physoc.org)
  • The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. (docphin.com)
  • Subcutaneous injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in mice caused hypothermia which was antagonized by pindolol. (naver.com)
  • When injected intraperitoneally into mice, endothelins ET-1, ET-2, ET-3 and big-endothelin-1 [1-(big-ET-1[1- produced a dose-related, robust and easily quantified. (naver.com)
Selectively1
Neuropharmacology1
Selective2
  • Environmental factors, such as malnutrition, selective serotonin reuptake inhibition, and changes in the expression of the serotonin transporter gene during the early stages of development may increase central serotonin availability, delay in satiety the trigger associated with hyperphagia, and reduce its anorexigenic effects in adult organisms [ 2 - 4 ]. (scielo.br)
  • Treatment of cord blood-derived mast cells with SDF-1 did not induce degranulation or the production of several cytokines but did induce a highly selective IL-8 response. (storysteel.cf)
Inhibitory1
Ipsapirone1
Neurons2
  • We found wide homogeneous distribution of firing rates, well fitted by a single Gaussian function ( r 2 = 0.93) and independent of anatomical location ( P = 0.45), suggesting that in terms of intrinsic firing properties, serotonergic neurons in the DRN represent a single cellular population. (frontiersin.org)
  • Thalamic OX7-saporin injections destroyed almost all layer VI neurons, which resulted in a 45% decrease in layer VI 8-OH-DPAT binding. (muscimol.xyz)
Induce1
  • Alternatively 5-HT either failed to induce a response (34 %), or depolarized neurones from -48 ± 2 mV to -43 ± 2 mV (n = 7/32). (physoc.org)
Dose5
  • All the monoamine reuptake blockers produced high-dose-appropriate responding in a dose-related manner when combined with a low dose of cocaine, but compounds from other pharmacological classes (benztropine, caffeine, diazepam, or 8-hydroxy-2-(di-n-propylamino)tetralin) did not enhance the DS effects of cocaine. (aspetjournals.org)
  • A single dose of 8-OH-DPAT reduces raphe binding of [ 3 H]8-OH-DPAT and increases the effect of raphe stimulation on 5-HT metabolism. (springer.com)
  • A administração do agonista 5-HT1A, 8-OH-DPAT (0,05 a 5,0 mg/kg), inibiu de modo dose-dependente a ingestão de alimento em codornas normoalimentadas. (scielo.br)
  • Using in vivo microdialysis, lecozotan (0.3 mg/kg s.c.) antagonized the decrease in hippocampal extracellular 5-HT induced by a challenge dose (0.3 mg/kg s.c.) of 8-hydroxy-2- dipropylaminotetralin (8-OH-DPAT) and had no effects alone at doses 10-fold higher. (elsevier.com)
  • En rotahaler price muzzily fonction de l'efficacité et de la tolérance, la dose peut être portée à 100 mg ou réduite à 25 mg. (lifftindia.com)
Effects5
  • When the stimulus duration was shortened, infusions of 8-OH-DPAT continued to improve accuracy, whereas M100907 decreased premature responding and omissions, thus partly dissociating the effects of these two compounds. (nih.gov)
  • Similar effects were obtained following systemic administration of M100907 and 8-OH-DPAT. (nih.gov)
  • Paroxetine, in combination with WAY 100635, attenuated the hypothermic effects of 8-OH-DPAT as early as 3 days, with a full reversal evident following 7 days, whereas paroxetine, although attenuating the hypothermic effects in OB group by day 7, only reversed it fully after 14 days. (austin.org.au)
  • The ability of the combination group to attenuate the hypothermic effects of 8-OH-DPAT faster than paroxetine alone, further emphasizes the role of the 5-HT1A receptor in the mechanism of action of antidepressants, and as a target for the development of faster acting antidepressants. (austin.org.au)
  • These effects were achieved after applying the cream 2 times in the first week and then 3 times per week thereafter, for a total of 3 months! (henderson-legal.com)
Increases1
  • [8] Vasodilation of the blood vessels in the skin via central 5-HT 1A activation increases heat dissipation from the organism out into the environment, causing a decrease in body temperature . (wikidoc.org)
ABSTRACT1
  • 1.1 Prostate Cancer Therapy A Historical View 156 2 Transgenic Mouse Models of Prostate Cancer 157 3 Prostate Cancer A Disease of Epithelial Differentiation 157 5 Definition of the Stem Cell Phenotype in Prostate 159 6 The Origins of Prostate Cancer 161 7 Isolation of Prostate Cancer Stem Cells 163 8 Gene Expression in Prostate Cancer Stem Cells 167 9 Implications for Prostate Cancer Therapy 170 Abstract. (clicktocurecancer.info)
Responses2
  • However, the prolactin responses to d-fenfluramine and 8-OH-DPAT were not significantly modified by cocaine exposure. (elsevier.com)
  • Aim 2 will determine whether the acidemia associated with hypovolemia or respiratory and metabolic acidosis per se contribute to activation of caudal hindbrain serotonin neural activation and subsequent respiratory and autonomic responses. (grantome.com)
Membranes6
  • A) Effect of 8-OH-DPAT on [ 35 S]-GTPγS binding to Sprague-Dawley rat brainstem membranes in the presence of DMSO or 100 nM THCV ( n = 11). (nih.gov)
  • B) Effect of 8-OH-DPAT ( n = 4) and THCV ( n = 6) on [ 35 S]-GTPγS binding to Sprague-Dawley rat brainstem membranes. (nih.gov)
  • C) Displacement of 8-[3H]-OH-DPAT from specific binding sites in Sprague-Dawley rat brainstem membranes by 8-OH-DPAT ( n = 4-9) or THCV ( n = 4-9). (nih.gov)
  • D) Effect of 8-OH-DPAT on [ 35 S]GTPγS binding to human 5-HT 1 A CHO cell membranes in the presence of DMSO (vehicle) or 100 nM THCV ( n = 8). (nih.gov)
  • E) Effect of 8-OH-DPAT ( n = 9) and THCV ( n = 10) on [ 35 S]GTPγS binding to human 5-HT 1 A CHO cell membranes. (nih.gov)
  • F) Displacement of 8-[ 3 H]-OH-DPAT from specific binding sites in human 5-HT 1 A CHO cell membranes by 8-OH-DPAT ( n = 6) and THCV ( n = 10). (nih.gov)
Gene Expression1
Journal1
Epub2
Significantly reduced1
Injection3
Decrease1
  • This decrease in bioavailability was about 5% when gabapentin was administered 2 hours after the antacid! (lifftindia.com)
20191
Results1
  • Indeed, although clinical trials of cannabis in affective disorders have yielded mixed results ( 7 , 8 ), many patients continue to report benefits from its use in primary or secondary depressive syndromes ( 9 - 13 ). (pnas.org)
Respiratory1
  • 1,2 However, it is perhaps respiratory depression that remains the main hazard of opioid use, uppermost in the minds of nurses and physicians, because of the obvious risk of fatal outcome. (asahq.org)
Response1
  • Additionally, the renin response to d-fenfluramine was unaltered by repeated cocaine administration, while 8-OH-DPAT did not alter renin secretion in either pretreatment group. (elsevier.com)
Research2
  • 8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. (wikipedia.org)
  • I have spent over 30 years involved in pharmacological and toxicological research, 8 of which have been in industry. (nuigalway.ie)
Spinal2
Tph21
  • To further analyze the importance of brain 5-HT in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-HT deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (Tph2). (uni-wuerzburg.de)
Contrast2
  • In contrast, 5-carboxamidotryptamine (5-CT, 1 μM) hyperpolarized RipCre neurones from -49 ± 1 to -68 ± 8 mV (n = 3/4). (physoc.org)
  • In contrast, 0.1 mg/kg of 8-OH-DPAT caused disruption only in the FH strain. (edu.au)