A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.
A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.
A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.
1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)
A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
Compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups. Members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains. They are possibly involved in the etiology of schizophrenia.
A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
Compounds that specifically inhibit the reuptake of serotonin in the brain.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT2 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT2 receptor subtypes.
A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Drugs that bind to and activate dopamine receptors.
A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.
Injections into the cerebral ventricles.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
A bacterial genus of the order ACTINOMYCETALES.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
The measure of the level of heat of a human or animal.
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
The observable response an animal makes to any situation.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
The physical activity of a human or an animal as a behavioral phenomenon.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods and Findings in ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 2C-B 2C-E 2C-T-2 4C-T-2 5-CT 5-MT 5-MeO-DiPT 5-MeO-DMT 5-MeO-MiPT 5-MeO-TMT 6-F-DMT Adatanserin αET Amphetamine[citation needed ...
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. Winstanley CA, ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 361 (2-3): 299-309. doi:10.1016/S0014-2999(98)00744-4. PMID 9865521. Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY ...
... di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist". Journal of Medicinal ... hydroxy-N,N-di-n-propyl-2-aminotetralin". Proceedings of the National Academy of Sciences of the United States of America. 89 ( ... "7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for ... N-dipropyl-7-hydroxy-2-aminotetralin". Naunyn-Schmiedeberg's Archives of Pharmacology. 336 (5): 494-501. doi:10.1007/bf00169305 ...
... di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine". Neurosci. Lett. 86 (1): 72-76. doi:10.1016/0304-3940( ... 318 (2-3): 403-409. doi:10.1016/S0014-2999(96)00777-7. PMID 9016931. Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, ... 323 (2-3): 235-240. doi:10.1016/S0014-2999(97)00029-0. PMID 9128844. Amemiya N, Hatta S, Takemura H, Ohshika H (1996). " ... ISBN 978-1-58829-568-2. S. Nigra / Domenech T, et al., 1997 Cortex / PEROUTKA ET AL., 1989 Cloned / ZGOMBICK JM, ET AL., 1992 ...
... di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular ... di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin. 15 (4): 377-84. doi:10.1016/0361-9230(85)90005-X. PMID ... di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ...
... di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH D04.615.638.960.675 ... vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1-naphthylamine MeSH D04.615.638.845.800 - ... 8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 - fusidic acid MeSH D04.808.247.808.607 - lanosterol MeSH D04.808.247.808.756 - ...
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... Aminoindani: 5-IAI • AMMI • ETAI • MDAI • MDMAI • MMAI • TAI; Aminotetralini: 6-CAT • 8-OH-DPAT • MDAT • MDMAT; Oksazolini: 4- ...
... di-n-propylamino)tetralin in rodents and nonhuman primate". Synapse (New York, N.Y.). 37 (1): 64-70. doi:10.1002/(SICI)1098- ... Karlsson A, Björk L, Pettersson C, Andén NE, Hacksell U (1990). "(R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): ... dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation". Journal ... propyl)amino-5-hydroxytetralin". Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National ...
... di-n-propylamino)tetralin (англ.) // Eur J Pharmacol. (англ.)русск. : journal. - 1994. - Vol. 253, no. 1-2. - P. 53-60. - doi: ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake (англ.) // Psychopharmacology (англ.)русск. : journal. - ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors (англ.) // Methods Find Exp ... 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Pharmacology Corner , Serotonin (5-HT): receptors, agonists and ...
... di-n-propylamino)tetralin.». Eur J Pharmacol. 253 (1-2): 53-60. PMID 8013549. doi:10.1016/0014-2999(94)90756-0. ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake». Psychopharmacology (Berl). 115 (1-2): 173-9. PMID 7862892. doi ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors». Methods Find Exp Clin ... doi:10.1016/S0091-3057(01)00712-2. *↑ a b Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E (2004). «Effects of a ...
... di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549.. ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology (Berl). 115 (1-2): 173-9. doi:10.1007/ ... Rev. 46 (2): 157-203. PMID 7938165.. *↑ Frazer A, Hensler JG (1999). "Chapter 13: Serotonin Receptors", in Siegel GJ, Agranoff ...
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... doi:10.1186/1758-2946-2-3. edit. *↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, ...
... di-n-propylamino)tetralin hydrobromide; CAS Number: 159795-63-8; Synonym: (±)-2-Dipropylamino-7-hydroxy-1,2,3,4- ... tetrahydronaphthalene hydrobromide, (±)-7-Hydroxy-DPAT hydrobromide, (±)-7-OH-DPAT hydrobromide; Linear Formula: C16H25NO · HBr ... di-n-propylamino)tetralin hydrobromide Synonym: (±)-7-Hydroxy-DPAT hydrobromide, (±)-7-OH-DPAT hydrobromide, (±). -. 2- ... di-n-propylamino)tetralin hydrobromide is a selective D3 dopamine receptor agonist (Kd ,1nM); has much weaker affinity for ...
... di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. ... di-n-propylamino)tetralin: 328*5-hydroxy-2-N,N-dipropylaminotetralin: 2 ... di-n-propylamino)tetralin: 328*5-hydroxy-2-N,N-dipropylaminotetralin: 2 ... di-n-propylamino)tetralin, (S)-Isomer; 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro- ...
... di-n-propylamino) tetralin (8-OH-DPAT) on food intake in non-deprived male rats were investigated. Low doses of 8-OH-DPAT (15- ... Microstructural analysis of the elicited feeding behaviour revealed that the rate of eating after 8-OH-DPAT treatment was very ... The effects of the putative serotonin agonist 8-hydroxy-2-( ... similar to those observed at doses of 15-60 micrograms/kg 8-OH- ... di-n-propylamino) tetralin (8-OH-DPAT) on food intake in non-deprived male rats were investigated. Low doses of 8-OH-DPAT (15- ...
... di-n-propylamino)tetralin Challenge. Rats (n = 48) in the 5-HT1A experiment received the same regimen of adolescent MDMA or ... di-n-propylamino)tetralin; AUC, area under the curve; WAY-100635, [3H]N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- ... di-n-propylamino)tetralin (8-OH-DPAT; Sigma Chemical, St. Louis, MO) or saline (s.c.). Animals were placed into clear glass ... di-n-propylamino)tetralin (8-OH-DPAT) (0.1 or 0.5 mg/kg). Adolescent MDMA exposure partially attenuated the hyperthermic ...
... di-n-propylamino] tetralin [8-OH-DPAT] following long-term consumption of sugar as part of meal in rats. Experimental study. ... After five weeks of treatment, control and sugar diet treated animals were injected with 8-OH-DPAT, at a dose of 0.5 mg/ml/kg, ... Administration of 8-OH-DPAT elicited hyperphagia and decreased 5-HT metabolism in normal diet treated rats. The neurochemical ... Attenuation of somatodendritic responses to 8-hydroxy-2-di-n-propylamino tetralin following long-term dietary sugar consumption ...
... di-n-propylamino) tetralin (8-OH-DPAT), a specific 5-HT1A receptor agonist, reduced electroencephalographic (EEG) seizures ... We studied whether the stimulation of 5-HT1A receptors by 8-hydroxy-2-( ... di-n-propylamino) tetralin (8-OH-DPAT), a specific 5-HT1A receptor agonist, reduced electroencephalographic (EEG) seizures ... 2. Pretreatment with 8-OH-DPAT 15 min earlier at the same site as kainic acid injection, caused a dose-dependent decrease of ...
... di-n-propylamino)tetralin (8-OH-DPAT) (0.25 mg/kg), and naloxone (3 … ... di-n-propylamino)tetralin (8-OH-DPAT) (0.25 mg/kg), and naloxone (3 mg/kg). All drugs, at the doses tested, were able to ... In N-(2-chloroethyl)-N-ethyl-2-2-bromobenzylamine (DSP4)-lesioned, sexually exhausted animals, naloxone and 8-OH-DPAT lost ... and 8-OH-DPAT Brain Res Bull. 1995;38(4):399-404. doi: 10.1016/0361-9230(95)02007-e. ...
... di-n-propylamino)tetralin, (-)- View Synonyms. View Structure. Detailed Summary. * Info Biological activities and chemical ...
... di-n-propylamino)tetralin). DA. dopamine. DS. discriminative stimulus. NE. norepinephrine. FR. fixed ratio. FRF. sum of the ... di-n-propylamino)tetralin) did not enhance the DS effects of cocaine. Analysis of the relationship between behavioral andin ... 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine). HDL. high-dose lever. MW. molecular weight. NE. norepinephrine. ... 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine. VTA. ventral tegmental area. ...
... di-n-propylamino)tetralin. A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. ... After successful resuscitation, animals were randomized to receive ABS 201 (8 mg/kg/h) or placebo. Postresuscitation myocardial ...
... di-n-propylamino)tetralin showed mild sensitization and marked desensitization of 5-HT1A receptors in Tph2-/- mice and Sert-/- ... When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both ... di-n-propylamino)tetralin showed mild sensitization and marked desensitization of 5-HT1A receptors in Tph2 -/- mice and Sert ... When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both ...
... di-N-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin; ... Agonisti: Lisergamidi: LSD; Triptamini: 5-CT • 5-MT • Bufotenin; Drugi: 8-OH-DPAT • AS-19 • Bifeprunoks • LP-12 • LP-44 • RU- ... Aminoindani: 5-IAI • AMMI • ETAI • MDAI • MDMAI • MMAI • TAI; Aminotetralini: 6-CAT • 8-OH-DPAT • MDAT • MDMAT; Oksazolini: 4- ...
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods and Findings in ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 2C-B 2C-E 2C-T-2 4C-T-2 5-CT 5-MT 5-MeO-DiPT 5-MeO-DMT 5-MeO-MiPT 5-MeO-TMT 6-F-DMT Adatanserin αET Amphetamine[citation needed ...
... di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis". Journal of Cardiovascular ... di-n-propylamino) tetralin (8-OH-DPAT)". Brain Research Bulletin. 15 (4): 377-84. doi:10.1016/0361-9230(85)90005-X. PMID ... di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology ... di-n-propylamino)tetralin". European Journal of Pharmacology. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549 ...
2 AND 3; Peroutka, 1988), among which the 5-HT1Asubtype has been the focus of intense research during the last... ... di-N-propylamino)tetralin, a selective serotonin1A receptor agonist. Psychopharmacology, 94, 84-91.PubMedCrossRefGoogle Scholar ... di-n-propylamino)tetralin, a selective serotonin1A receptor agonist. Eur. J. Pharmacol., 144, 223-9.PubMedCrossRefGoogle ... di-n-propylamino)tetralin (8-OH-DPAT). Eur. J. Pharmacol., 105, 365-8.PubMedCrossRefGoogle Scholar ...
... di-n-propylamino)tetralin (8-OH-DPAT). In conscious, unrestrained rabbits, instrumented for recordings of heart rate, arterial ... Systemically administered 8-OH-DPAT (0.004-0.1 mg/kg) substantially attenuated these responses in a dose-dependent manner. Drug ... microinjection of 8-OH-DPAT (500 nl of 10 mM solution) into the medullary raphe-parapyramidal region caused antitachycardic ... 2 and +15 +/- 3 mmHg, respectively). Lipopolysaccharide injection caused sustained increases in heart rate (from 210 +/- 3 to ...
... tetralin (8-OH-DPAT), a selective 5-HT1A agonist; and caffeine, a nonselective antagonist of adenosine receptors. RESULTS: ... Fluoxetine and 8-OH-DPAT partially substituted for tianeptine by producing >50% of tianeptine-appropriate lever responding. In ...
... di-n-propylamino)tetralin. Pharmacol Biochem Behav 66:483-488CrossRefPubMedGoogle Scholar ... Di Benedetto M, Bastias Candia Sdel C, DAddario C, Porticella EE, Cavina C, Candeletti S et al (2011) Regulation of opioid ... 2.. Sami M, Piggott K, Coysh C, Fialho A (2015) Psychosis, psychedelic substance misuse and head injury: a case report and 23 ... 8.. Fiorella D, Rabin RA, Winter JC (1995) Role of 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs ...
... di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model.. Cinar O, Durmus N, Aslan G, Demir O, ... Effects of the dopamine D3 receptor agonist 7-hydroxy-2-( ... 2015 Aug;170(2):409-18. doi: 10.1016/j.ahj.2015.04.025. Epub ... 2.. Comparison of ultrasound-guided transversus abdominis plane block, quadratus lumborum block, and caudal epidural block for ... 2015 Oct;53(8):779. doi: 10.1016/j.bjoms.2015.05.005. Epub 2015 Jun 3. No abstract available. ...
... di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function. Neuropharmacology 24:1187-1194. ... At day 8 (arrow), only an amount of food equivalent to 8% of the sum of the mouse body weight per cage was provided. B, Food ... Figure 2. Social interaction against an intruder is significantly decreased in X11L-KO mice. A-C, The resident-intruder test ( ... 2A-C, available at www.jneurosci.org as supplemental material). In the hippocampus, no differences were detected between X11L- ...
... di-n-propylamino)tetralin (8-OH-DPAT). Flesinoxan was inactive as an agonist. Ketanserin (1 μmol/l) hardly affected sumatriptan ... It is also to be noted that 2-methyl-5-HT, considered selective for the 5-HT3 receptor, contracts the saphenous vein mainly via ... RU 24969 and 8-OH-DPAT) and their reported binding affinities for the 5-HT1D receptor in human or calf brain membranes. Such a ... the contractions elicited by 2-methyl-5-HT were not attenuated by ICS 205-930, but were antagonized by methiothepin (0.1 μmol/l ...
... di-n-propylamino)tetralin (8-OH-DPAT)IBA 01/2013. ... 2/2009. Enhancement of the breathing frequency response to ... 8/2011. Alteration of carotid body chemoreflexes after neonatal intermittent hypoxia and caffeine treatment in rat pups.. ... 8/2010. Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic ...
... di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- ... di-n-propylamino)-tetralin; N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane-carboxamide] and an ... Todd AJ, Hughes DI, Polgar E, Nagy GG, Mackie M, Ottersen OP, Maxwell DJ (2003) The expression of vesicular glutamate ... Effects of 2-Me 5-HT. A, B, Time course and mean depression evoked by 2-Me 5-HT as in Figure 3, A and B. The plots are based on ...
... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an actio.... 11786239 - The effect of naloxone on operant ... 8402149 - Predator-induced opioid and non-opioid mediated analgesia in young meadow voles: sex di.... 21576929 - Hypothalamic ... Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, ... Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob ...
... di-n-propylamino)-tetralin (8-OH-DPAT) on food intake were investigated in food-deprived rats. 8-OH-DPAT (25-100 microg/kg) ... 5-hydroxy-indole-acetic acid ... ... di-n-propylamino)-tetralin (8-OH-DPAT) on food intake in non- ... di-n-propylamino)-tetralin (8-OH-DPAT) were investigated on food intake in non-deprived mice. 8-OH-DPAT (50-200 mg/kg) ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A ... ...
... di-n-propylamino) tetralin (8-OH-DPAT; 0.15 mg/kg) impaired rats rapid visual learning on a computerized maze. This treatment ... Whereas the inverse process occurs during lipolysis; i.e. an increase in the proportion of the acids in the 2 position. In the ... In the presence of ionomycin and either 1,2-dioctanoylglycerol or phorbol 12-myristate 13-acetate, the release of serotonin ... The last of 8 rats surviving the period of tryptophan-deficiency died at 45.50 months (1387 days) while the last of 14 control ...
... di-n-propylamino)tetralin". Eur. J. Pharmacol. 253 (1-2): 53-60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549.. ... di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin ... di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology. 115 (1-2): 173-9. doi:10.1007/BF02244769. ... 290 (2): R405-13. doi:10.1152/ajpregu.00440.2005. PMID 16166206.. *↑ 57.0 57.1 Van de Kar LD, Levy AD, Li Q, Brownfield MS ( ...
... propylamino) tetralin (8-OH-DPAT: 5-HT1A receptor agonist) on two strains of chicks (Cobb and Ross Chunky) was examined. ... Food intake in Ross Chunky enhanced by the highest dose of 8-OH-DPAT, but not in Cobb. The difference of sensitivity for 5-HT ... In experiment 2, four mature ruminally cannulated steers were used to determine kinetics of in situ ruminal digestion of DM, ... Kid live weight gain was similar among treatments in Phases 1 (108, 133, 118, and 113 g/d) and 2 (82, 40, 43, and 78 g/d) and ...
... di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.Eur.J.Pharmacol.. 373. 171-179 (1999). *. Related Report. ... di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.Eur.J.Pharmacol.. 373. 171-179 (1999). *. Description. 「研究 ... di-n-propylaminc)tetrdlin on the monosynaptic spinal reflex in ratsEur. J. Pharmacol.. 373. 171-179 (1999). *. Description. 「研 ... 2.We showed that cyclobenzaprine, and amitriptyline and cyproheptadine, analogs of cyclobenzaprine blocked the 5-HT2 receptors ...
... di-n-propylamino) tetralin(8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats WADA Y ... 2. Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system : single cell studies in the rat ... 脳波と筋電図 : Japanese journal of electroencephalography and electromyography 23(2), 258-264, 1995-04-30 ...
  • The effects of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on food intake in non-deprived male rats were investigated. (ox.ac.uk)
  • To determine changes in response to a selective serotonin -1 A receptor agonist 8-hydroxy-2-[di-n-propylamino] tetralin [ 8-OH-DPAT ] following long-term consumption of sugar as part of meal in rats . (bvsalud.org)
  • Administration of 8-OH-DPAT elicited hyperphagia and decreased 5-HT metabolism in normal diet treated rats . (bvsalud.org)
  • 1. We studied whether the stimulation of 5-HT1A receptors by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a specific 5-HT1A receptor agonist, reduced electroencephalographic (EEG) seizures induced by intrahippocampal injection of 0.04 microgram in 0.5 microliter of the glutamate analogue kainic acid in freely-moving rats. (nih.gov)
  • 8-hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin 1A receptor agonist, reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis. (springer.com)
  • Publications] M.Honda and H.Ono: 'Differential effects of (R)-and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats. (nii.ac.jp)
  • The ACTH responses to d-fenfluramine and 8-OH-DPAT were inhibited in cocaine pretreated rats. (elsevier.com)
  • Because FSL rats were more sensitive to 5-HT1A receptor agonists, high (HDS) and low (LDS) 8-OH-DPATsensitive lines were selectively bred for differential hypothermic responses to the 5-HT1A receptor agonist, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT). (scirp.org)
  • Because FSL rats have increased sensitivity to the hypothermic response to 8-hydroxy-2-(diN-propylamino)tetralin (8-OH-DPAT) [5] [6] , interest in the potential involvement of the 5-HT1A receptor in their depressive phenotype was sparked. (scirp.org)
  • 8-OH-DPAT treatment reduced the blood pressure increase in FH rats and WKY rats, but had no effect in SHR and enhanced the pressor response in SD rats. (edu.au)
  • Increasing doses of the 5-HT(1A) receptor agonist 8-OH-DPAT caused disruption of PPI, with the effect being significantly greater in FH rats compared to WKY rats. (edu.au)
  • The PE model was established by injection of 8-OH-DPAT in 10 ml normal saline at 0.8 mg per kg of the body weight per day into the subarachnoid space of the lumbosacral spinal cord segments and the control rats were injected with the same volume of normal saline only, both for 4 weeks. (bvsalud.org)
  • At 2 and 4 weeks, the male rats were mated with the female ones for 30 minutes each time and meanwhile observed for their mating behavior indicators, such as mount latency, intromission latency, ejaculation latency, mount frequency, intromission frequency, and ejaculation frequency. (bvsalud.org)
  • 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. (bvsalud.org)
  • IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. (bvsalud.org)
  • Seven days later rats entered a protocol of 8-OH-DPAT, a 5-HT1A agonist, in which locomotor activity, ASR and PPI and their tissue levels of 5-HT were measured. (bvsalud.org)
  • 8-OH-DPAT strengthened the ASR in IR but not SOC rats and the drug-reduced PPI could be adjusted by 5,7-DHT pretreatment. (bvsalud.org)
  • 8-OH-DPAT at 100 μg/kg enhanced PPI in 5-HT-depleted SOC rats. (bvsalud.org)
  • However for IR rats, 8-OH-DPAT strengthened PPI in sham rats but downgraded it in depletion condition. (bvsalud.org)
  • and D,L-5-hydroxytryptophan, an immediate precursor) or which can mimic 5-HT (e.g., 5-HT 1 and 5-HT 2 agonists) all significantly decreased the volitional alcohol intake of the high alcohol-seeking rats. (elsevier.com)
  • Similarly, the IP administration of a DA uptake inhibitor, DA releaser or D 2 agonist also reduced the volitional oral intake of alcohol by the P line of rats. (elsevier.com)
  • Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. (ox.ac.uk)
  • One week later on PD 67, animals were challenged with either multiple doses of MDMA (four 5 or 10 mg/kg doses) or a single dose of the 5-HT 1A agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT) (0.1 or 0.5 mg/kg). (aspetjournals.org)
  • 4. The anticonvulsant action of 8-OH-DPAT given intrahippocampally or systemically was significantly blocked by 5 micrograms, but not 1 microgram WAY 100635, a selective 5-HT1A receptor antagonist, administered in the hippocampus before the agonist. (nih.gov)
  • First, application of the 5-HT 1A -selective agonist R(+)-8-hydroxy-2-(di-n-propylamino)tetralin showed mild sensitization and marked desensitization of 5-HT 1A receptors in Tph2 -/- mice and Sert -/- mice, respectively. (frontiersin.org)
  • Kasnije je utvrđeno da 8-OH-DPAT takođe deluje kao agonist 5-HT 7 receptora i kao inhibitor serotoninskog preuzimanja / agens serotoninskog otpuštanja . (wikipedia.org)
  • Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well. (wikipedia.org)
  • Potential anxiolytic properties of 8-hydroxy-2-(di-N-propylamino)tetralin, a selective serotonin 1A receptor agonist. (springer.com)
  • In the present study, we attempted to suppress cardiac sympathetic nerve activity by affecting the relevant cardiomotoneurons in the brain using the selective serotonin-1A (5-HT(1A)) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). (semanticscholar.org)
  • Effects of the dopamine D 3 receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model. (nih.gov)
  • Atropine (muscarinic cholinergic blocking agent), pyrilamine maleate (PM, histamine H 1 blocker), cimetidine (histamine H 2 blocker), 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OHDPAT, specific 5-HT 1A receptor agonist) and SCH-23390 (selective dopamine D 1 receptor antagonist) were examined on the cough response to inhaled capsaicin in conscious guinea-pigs. (elsevier.com)
  • However, the 5-HT 1A receptor agonist, 8-hydroxy-di-n-propylamino tetralin (8-OH DPAT, 1 μM), failed to alter excitability (n = 4). (physoc.org)
  • The administration of 5-HT1A agonist, 8-OH-DPAT (0.05 to 5.0 mg/Kg) dose-dependently inhibited the food intake in normally fed quails. (scielo.br)
  • Fluoxetine, a selective serotonin reuptake inhibitor, shows moderate efficacy and potency in the rat forced swimming depression test and the shock-induced ultrasonic vocalization anxiety test, whereas the 5-HT(1A) receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is highly efficient and potent in both models. (unboundmedicine.com)
  • In a dose finding study, 4 subjects received each of 0.05, 0.1, 0.5 mg/kg 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, a serotonin 1A receptor agonist) or saline vehicle subcutaneously. (asp.org)
  • Eight male subjects were administered 0.1mg/kg 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, a selective serotonin 1A receptor agonist) or saline vehicle daily for 15 consecutive days. (asp.org)
  • Fluoxetine attenuated the 5-HT 1A receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT)-induced hypothermia, decrease in DR 5-HT neuronal activity and 5-HT release in both vehicle- and corticosterone-pre-treated mice. (aspetjournals.org)
  • Harikumar, KG & Chattopadhyay, A 1998, ' Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols ', FEBS Letters , vol. 438, no. 1-2, pp. 96-100. (elsevier.com)
  • In drug discrimination studies, lecozotan (0.01-1 mg/kg i.m.) did not substitute for 8-OH-DPAT and produced a dose-related blockade of the 5-HT 1A agonist discriminative stimulus cue. (elsevier.com)
  • Treatment with the selective 5-HT(1A) serotonin receptor agonist 8-OH-DPAT (0.1, 0.25, 0.5 and 2.0 mg/kg) induced a dose-dependent decrease in the amount of time spent by the males near the partition , or "partition time", which is considered the main pattern of sexual motivation . (longecity.org)
  • The 5-HT(1A) antagonist p-MPPI (0.1, 0.2 and 0.4 mg/kg) itself did not affect behavior or alter plasma testosterone, but attenuated the inhibiting effect of 8-OH-DPAT on behavior and totally antagonised the effect of the 5-HT(1A) agonist on testosterone response. (longecity.org)
  • Further to the OB study, we simultaneously studied adaptive changes in 5-HT1A receptor function, utilizing alterations in the hypothermic response to the 5-HT1A receptor agonist 8-OH-DPAT. (austin.org.au)
  • In the DRN and MRN, the stimulation of [ 35 S]GTPγS binding by the 5-HT 1A receptor agonist 8-OH-DPAT, or the number of 5-HT 1A receptor sites labeled with [ 3 H]MPPF, was not different in old versus young animals. (uthscsa.edu)
  • In the DRN and MRN, the stimulation of [35S]GTPγS binding by the 5-HT1A receptor agonist 8-OH-DPAT, or the number of 5-HT1A receptor sites labeled with [3H]MPPF, was not different in old versus young animals. (uthscsa.edu)
  • Prior work in these laboratories identified (±)-5-hydroxy-6-methyl-2-(di-n-propylamino)tetralin as a dopaminergic agonist prodrug. (elsevier.com)
  • The ortho methyl hydroxy aromatic substitution pattern in this molecule has now been incorporated into the aporphine ring system to give a congener of the dopaminergic agonist apomorphine in which the position 10 OH group has been replaced by methyl. (elsevier.com)
  • Surprisingly, the target compound elicited no responses in any assays for effects at dopamine receptors, but rather it displayed pharmacological properties consistent with its being a serotonergic agonist with a high degree of selectivity for 5-HT 1A receptors similar to the serotonergic agonist 8-hydroxy-2-(di-n-propylamino)tetralin. (elsevier.com)
  • The effects of 8-OH-DPAT, an agonist of 5-HT1AR, on the proliferation (cell number), viability, apoptosis, spontaneous release of histamine, as well as a possible 5-HT metabolism, in the human HMC-1 mast cell line, were investigated. (nyu.edu)
  • Effects of the dopamine D3 receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hypertroidism. (deu.edu.tr)
  • Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin. (naver.com)
  • British Journal of Pharmacology , 109 (2), 437-442. (hw.ac.uk)
  • Naunyn-Schmiedeberg's Archives of Pharmacology 345 (2): 129-36. (worldlibrary.net)
  • European Journal of Pharmacology 253 (1-2): 53-60. (worldlibrary.net)
  • 5. These results indicate that postsynaptic 5-HT1A receptors in the hippocampus mediate the anticonvulsant action of 8-OH-DPAT and that their stimulation has an inhibitory role in the generation of limbic seizures. (nih.gov)
  • It is also to be noted that 2-methyl-5-HT, considered selective for the 5-HT3 receptor, contracts the saphenous vein mainly via 5-HT2 receptors. (eur.nl)
  • In previous studies, axons possessing 5-HT 3 receptors were found to be excitatory, and as 2-Me 5-HT depressed transmission to dorsal horn interneurons, the results indicate that 5-HT operates at 5-HT 3 receptors presynaptic to these neurons to depress excitatory transmission. (jneurosci.org)
  • 2.We showed that cyclobenzaprine, and amitriptyline and cyproheptadine, analogs of cyclobenzaprine blocked the 5-HT2 receptors in the spinal cord, and consequently depressed the monosynaptic reflexes. (nii.ac.jp)
  • In vitro studies investigated the effect of THCV on targeting by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) of 5-HT₁A receptors in membranes obtained from rat brainstem or human 5-HT₁A CHO cells, using [(35)S]-GTPγS and 8-[(3)H]-OH-DPAT binding assays. (nih.gov)
  • and (iv) at 100 nM, significantly enhanced 8-OH-DPAT-induced activation of these human 5-HT₁A receptors. (nih.gov)
  • The data support the hypothesis that the antidepressant- and anxiolytic-like effect of 8-OH-DPAT is predominantly mediated by post- and presynaptic 5-HT(1A) receptors, respectively, and that 5-HT(1A) receptors are only partially involved in the antidepressant-like effect of fluoxetine. (unboundmedicine.com)
  • Cannabis elicits in humans a complex subjective experience, a combination of mood elevation, heightened sensitivity to external stimuli, and relaxation ( 1 ), which results from the interaction of its main psychoactive constituent, Δ 9 -tetrahydrocannabinol (Δ 9 -THC), with CB 1 cannabinoid receptors in the brain ( 2 ). (pnas.org)
  • There are 14 different serotonin receptors ( 2 ), some of which have multiple splice variants that enable binding of distinct sets of intracellular proteins ( 5 ). (sciencemag.org)
  • Pharmacologic and genetic studies have suggested a role for 5-HT 1B receptors in the pathophysiology of obsessive compulsive disorder, drug addiction, depression, anxiety, aggression, and sleep ( 1 , 7 , 8 ). (sciencemag.org)
  • p11 interacted with 5-HT 1B receptors, but not with 5-HT 1A , 5-HT 2A , 5-HT 5A , 5-HT 6 , dopamine D 1 or D 2 receptors, two irrelevant baits (CΔ115 and pRP21), or the empty plasmid, which showed the specificity of this interaction ( Fig. 1A ). (sciencemag.org)
  • 7,8 These findings confirm that μ-opioid receptors are the key targets for opioid-induced respiratory depression. (asahq.org)
  • 2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors. (docphin.com)
  • Effects on the serotonin system, especially serotonin-2 receptors, may contribute to clozapine's atypicality. (ox.ac.uk)
  • 5-Hydroxytryptamine (5-HT)2 receptors can be partially characterized by their sensitivity to ketanserin blockade and increase in phosphoinositide turnover upon stimulation. (mysciencework.com)
  • Adolescent MDMA-treated animals also showed a partial attenuation of the serotonin syndrome but not the hypothermic response to the high dose of 8-OH-DPAT. (aspetjournals.org)
  • These results suggested that berberine at 100 mg/kg had a significant anxiolytic-like effect, which was similar to that observed with 1 mg/kg diazepam and 2 mg/kg buspirone. (longecity.org)
  • We studied the effect of treatment with the serotonin-1A (5-HT1A) receptor ligands buspirone, 8-hydroxy-di-propyl-aminotetralin (8-OH-DPAT), and (8-[2-(2,3-dihydro-1,4-benzodioxin-2-yl-methylamino)ethyl]-8-azaspiro[4,5]decane-7,9-dione methyl sulphonate (MDL73,005EF) on blood pressure and heart rate increases to open field stress. (edu.au)
  • N -(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride] were investigated on dorsal horn interneurons mediating reflex actions of group II muscle afferents. (jneurosci.org)
  • 5. The effects of serotonin on intrinsic properties and EPSPs were partially mimicked by 5-HT1A receptor agonists (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT) and 5-carboxamido-tryptamine maleate (5-CT), and reduced by 5-HT1A receptor antagonists S-(-)-5-fluoro-8-hydroxy-DPAT hydrochloride (S-UH-301), 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide (NAN-190) and spiperone. (mdc-berlin.de)
  • Whereas the 5-HT(1A) receptor antagonist WAY 100,635 abolishes the effect of 8-OH-DPAT in both models, it only attenuates the antidepressant-like effect of fluoxetine. (unboundmedicine.com)
  • A novel 5-HT 1A receptor antagonist, 4-cyano-N-{2R-[4-(2,3-dihydrobenzo[1,4]-dioxin-5-yl)-piperazin-1- yl]-propyl}-N-pyridin-2-yl-benzamide HCl (lecozotan), which has been characterized in multiple in vitro and in vivo pharmacological assays as a drug to treat cognitive dysfunction, is reported. (elsevier.com)
  • Learning deficits induced by the glutamatergic antagonist MK-801 [(-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate] (assessed by perceptually complex and visual spatial discrimination) and by specific cholinergic lesions of the hippocampus (assessed by visual spatial discrimination) were reversed by lecozotan (2 mg/kg i.m.) in marmosets. (elsevier.com)
  • 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT 1 antagonist, (±)-pindolol, whereas a selective 5-HT 2 antagonist, ritanserin was inactive. (fujita-hu.ac.jp)
  • 8-OH- DPAT-induced memory impairment was inhibited by a nonselective 5-HT antagonist, methysergide and a 5-HT1 antagonist, (±)-pindolol, whereas a selective 5-HT2 antagonist, ritanserin was inactive. (fujita-hu.ac.jp)
  • Austin Health Research Online: Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. (austin.org.au)
  • Remarkably, the contractions elicited by 2-methyl-5-HT were not attenuated by ICS 205-930, but were antagonized by methiothepin (0.1 μmol/l) and, more markedly, by ketanserin (1 μmol/l). (eur.nl)
  • 3. Serotonin depressed mixed as well as isolated {alpha}-amino-3-hydroxy-5-methyl-4-isoxazole- propionic acid receptor (AMPAR)- and N-methyl-D-aspartic acid receptor (NMDAR)-mediated excitatory postsynaptic potentials/currents (EPSPs/EPSCsapproximately 40 % reduction with 1 microM serotonin). (mdc-berlin.de)
  • Importantly, most commercially available anthelmintics have become increasingly ineffective because of growing resistance (benzimidazoles, levamisole and, most recently, ivermectin) and most nematicides (DCBP (1,2-dibromo-3-chloropropane), methyl bromide), to control plant nematodes, have been banned by the EPA because of human toxicity [ 8 - 13 ]. (prolekare.cz)
  • With regard to agonists, the 5-HT2 receptor agonists DOI and alpha-methyl-5-HT contracted guinea pig trachea with greater potency than quipazine, 5-methoxytryptamine, 5-carboxamidotryptamine, 8-hydroxy-2-(di-N-propylamino)tetralin and 2-methyl-5-HT. (mysciencework.com)
  • We hypothesized that acute 8-OH-DPAT would selectively increase, while chronic 8-OH-DPAT would decrease, affiliative behavior. (asp.org)
  • 05). Behaviorally, there appeared to be two sub-populations with regard to sensitivity to 8-OH-DPAT, which predicted affiliative behavior post-injection. (asp.org)
  • There was a high correlation between the functional pD2 values of 5-HT1-like receptor agonists (5-CT, 5-HT, methysergide, sumatriptan, RU 24969 and 8-OH-DPAT) and their reported binding affinities for the 5-HT1D receptor in human or calf brain membranes. (eur.nl)
  • Here, we investigated how persistent alterations in brain 5-HT availability affect autoinhibition in two genetically modified mouse models lacking critical mediators of serotonergic transmission: 5-HT transporter knockout ( Sert -/-) and tryptophan hydroxylase-2 knockout ( Tph2 -/-) mice. (frontiersin.org)
  • When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy- L -tryptophan (5-HTP), neurons from both Tph2 -/- and Sert -/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls. (frontiersin.org)
  • In the mice fed with a normal diet, the cumulative food intake significantly decreased at 20 min and 1 h after the administration of 1 mg/kg of BVD-74D and at 1, 2, 4, 8, and 24 h after the administration of 10 mg/kg of BVD-74D. (biomedsearch.com)
  • Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, and 4 h after BVD-74D (10 mg/kg) administration. (biomedsearch.com)
  • Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob/ob mice. (biomedsearch.com)
  • 2002). Recently we have identified a novel arcuate neuronal population in mice, which regulate energy homeostasis, by the expression of green fluorescent protein (GFP) induced by the rat insulin 2 promoter (RipCre) transgene (Choudhury et al. (physoc.org)
  • 2005). Mice (8-16 weeks) were humanely killed. (physoc.org)
  • The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. (docphin.com)
  • 2. Pretreatment with 8-OH-DPAT 15 min earlier at the same site as kainic acid injection, caused a dose-dependent decrease of kainic acid-induced seizure activity. (nih.gov)
  • Additionally, the renin response to d-fenfluramine was unaltered by repeated cocaine administration, while 8-OH-DPAT did not alter renin secretion in either pretreatment group. (elsevier.com)
  • Pretreatment with the 5-HT-depleting agent parachlorophenylalanine attenuates the antidepressant-like effect of fluoxetine, but not that of 8-OH-DPAT. (unboundmedicine.com)
  • BER also attenuated the anxiogenic effect of WAY-100635, 8-OH DPAT and DOI and enhanced the anxiolytic effect of BUS, p-MPPI and RIT in the elevated plus-maze. (longecity.org)
  • After five weeks of treatment , control and sugar diet treated animals were injected with 8-OH-DPAT , at a dose of 0.5 mg/ml/kg, to monitor the effects of drug on food intake and brain serotonin [ 5-hydroxytryptamine , 5-HT ] metabolism . (bvsalud.org)
  • All the monoamine reuptake blockers produced high-dose-appropriate responding in a dose-related manner when combined with a low dose of cocaine, but compounds from other pharmacological classes (benztropine, caffeine, diazepam, or 8-hydroxy-2-(di-n-propylamino)tetralin) did not enhance the DS effects of cocaine. (aspetjournals.org)
  • A single dose of 8-OH-DPAT reduces raphe binding of [ 3 H]8-OH-DPAT and increases the effect of raphe stimulation on 5-HT metabolism. (springer.com)
  • A administração do agonista 5-HT1A, 8-OH-DPAT (0,05 a 5,0 mg/kg), inibiu de modo dose-dependente a ingestão de alimento em codornas normoalimentadas. (scielo.br)
  • Using in vivo microdialysis, lecozotan (0.3 mg/kg s.c.) antagonized the decrease in hippocampal extracellular 5-HT induced by a challenge dose (0.3 mg/kg s.c.) of 8-hydroxy-2- dipropylaminotetralin (8-OH-DPAT) and had no effects alone at doses 10-fold higher. (elsevier.com)
  • 3. Systemic administration of 25, 100 and 1000 micrograms kg-1 8-OH-DPAT significantly reduced the total number of seizures and the total time in seizures induced by intrahippocampal kainic acid by 52% and 74% on average. (nih.gov)
  • Low doses of 8-OH-DPAT (15-60 micrograms/kg) significantly increased food intake, without affecting drinking, grooming, rearing or locomotion. (ox.ac.uk)
  • As drug-induced stereotypy declined with time, this fragmented pattern of eating was succeeded by long bouts of eating which were similar to those observed at doses of 15-60 micrograms/kg 8-OH-DPAT. (ox.ac.uk)
  • In all strains, treatment with 0.5 mg/kg of 8-OH-DPAT significantly reduced PPI. (edu.au)
  • Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. (docphin.com)
  • 2. RO 5-4864, also a peripheral type benzodiazepine compound, displayed low affinity for the [ 3 H]-PK 11195 site in the gerbil (pK(i) 6.57 ± 0.02 and 6.70 ± 0.12 in hippocampus and cortex respectively) compared to rat (pK(i) 8.16 ± 0.07 and 8.48 ± 0.02). (hw.ac.uk)
  • Environmental factors, such as malnutrition, selective serotonin reuptake inhibition, and changes in the expression of the serotonin transporter gene during the early stages of development may increase central serotonin availability, delay in satiety the trigger associated with hyperphagia, and reduce its anorexigenic effects in adult organisms [ 2 - 4 ]. (scielo.br)
  • This study analyzes the impact of a neurotoxic lesion of the central noradrenergic system on the pharmacological reversal of the sexual inhibition present at sexual exhaustion, by IP treatment with yohimbine (2 mg/kg), 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (0.25 mg/kg), and naloxone (3 mg/kg). (nih.gov)
  • Fluoxetine and 8-OH-DPAT partially substituted for tianeptine by producing >50% of tianeptine-appropriate lever responding. (biopsychiatry.com)
  • A) Effect of 8-OH-DPAT on [ 35 S]-GTPγS binding to Sprague-Dawley rat brainstem membranes in the presence of DMSO or 100 nM THCV ( n = 11). (nih.gov)
  • B) Effect of 8-OH-DPAT ( n = 4) and THCV ( n = 6) on [ 35 S]-GTPγS binding to Sprague-Dawley rat brainstem membranes. (nih.gov)
  • C) Displacement of 8-[3H]-OH-DPAT from specific binding sites in Sprague-Dawley rat brainstem membranes by 8-OH-DPAT ( n = 4-9) or THCV ( n = 4-9). (nih.gov)
  • D) Effect of 8-OH-DPAT on [ 35 S]GTPγS binding to human 5-HT 1 A CHO cell membranes in the presence of DMSO (vehicle) or 100 nM THCV ( n = 8). (nih.gov)
  • E) Effect of 8-OH-DPAT ( n = 9) and THCV ( n = 10) on [ 35 S]GTPγS binding to human 5-HT 1 A CHO cell membranes. (nih.gov)
  • F) Displacement of 8-[ 3 H]-OH-DPAT from specific binding sites in human 5-HT 1 A CHO cell membranes by 8-OH-DPAT ( n = 6) and THCV ( n = 10). (nih.gov)
  • Epub 2019 Jul 2. (nih.gov)
  • EPMA J . 2019 May 25;10(2):115-123. (nih.gov)
  • Thalamic OX7-saporin injections destroyed almost all layer VI neurons, which resulted in a 45% decrease in layer VI 8-OH-DPAT binding. (muscimol.xyz)
  • Blood samples were taken 15 and 45 minutes post injection on days 1, 3, 8, 10 and 15. (asp.org)
  • [email protected]#To explore the feasibility and practicability of establishing a rat model of premature ejaculation (PE) by injection of 8-OH-DPAT into the subarachnoid space of the lumbosacral spinal cord segments. (bvsalud.org)
  • [email protected]#A rat model of premature ejaculation was successfully established by injection of 8-OH-DPAT into the subarachnoid space of the lumbosacral spinal cord segments, which is of great significance for further study of the mechanism of premature ejaculation. (bvsalud.org)
  • [7] [8] Vasodilation of the blood vessels in the skin via central 5-HT 1A activation increases heat dissipation from the organism out into the environment, causing a decrease in body temperature . (wikidoc.org)
  • Dorsal raphe lesions abolish effects of 8-OH-DPAT and ipsapirone in the X-maze. (springer.com)
  • Paroxetine, in combination with WAY 100635, attenuated the hypothermic effects of 8-OH-DPAT as early as 3 days, with a full reversal evident following 7 days, whereas paroxetine, although attenuating the hypothermic effects in OB group by day 7, only reversed it fully after 14 days. (austin.org.au)
  • The ability of the combination group to attenuate the hypothermic effects of 8-OH-DPAT faster than paroxetine alone, further emphasizes the role of the 5-HT1A receptor in the mechanism of action of antidepressants, and as a target for the development of faster acting antidepressants. (austin.org.au)
  • Objective Here, we investigated the effect of constitutively impaired 5-HT synthesis on behavioral and neuroendocrine responses to unpredictable chronic mild stress (CMS) using a mouse model of brain 5-HT deficiency resulting from targeted inactivation of the tryptophan hydroxylase-2 (Tph2) gene. (uni-wuerzburg.de)
  • To further analyze the importance of brain 5-HT in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-HT deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (Tph2). (uni-wuerzburg.de)
  • 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) and 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (PAPP) given immediately after training caused impairment of memory. (fujita-hu.ac.jp)
  • Microstructural analysis of the elicited feeding behaviour revealed that the rate of eating after 8-OH-DPAT treatment was very similar to that previously reported following 16 h food deprivation. (ox.ac.uk)
  • The neurochemical and hyperphagic responses to 8-OH-DPAT were smaller in sugar than normal diet treated animals suggesting a downregulation of somatodendritic responses in sugar diet treated animals . (bvsalud.org)
  • However, the prolactin responses to d-fenfluramine and 8-OH-DPAT were not significantly modified by cocaine exposure. (elsevier.com)
  • Application of 5-HT to the perfusion solution (1 μM) or ejection (2 μM) directly above the recording neurone had a mixed affect on neuronal excitability. (physoc.org)
  • There was a decrease in (+/-)8-OH-DPAT-stimulated [ 35 S]GTPγS binding in the dorsal raphe, which did not reach statistical significance. (uthscsa.edu)
  • Indeed, although clinical trials of cannabis in affective disorders have yielded mixed results ( 7 , 8 ), many patients continue to report benefits from its use in primary or secondary depressive syndromes ( 9 - 13 ). (pnas.org)
  • 1,2 However, it is perhaps respiratory depression that remains the main hazard of opioid use, uppermost in the minds of nurses and physicians, because of the obvious risk of fatal outcome. (asahq.org)