Benzopyrenes
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Benzo(a)pyrene
Sphingosine N-Acyltransferase
Pteridines
Nitric Oxide Synthase
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Leukotriene B4
Ceramides
Dihydroxydihydrobenzopyrenes
Molecular Structure
Stereoisomerism
Nitric Oxide Synthase Type II
Oxides
Benzopyrene Hydroxylase
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Chromatography, High Pressure Liquid
Chemistry
Spectrophotometry, Ultraviolet
Nitric Oxide Synthase Type III
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
DNA Adducts
Carcinogens
Mass Spectrometry
Nitric Oxide Synthase Type I
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Mutagens
Substrate Specificity
Epoxy Compounds
UPF0488
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... "C8orf33 chromosome 8 open reading frame 33 [Homo sapiens]". Entrez Gene. Ma C, Chen HI, Flores M, Huang Y, Chen Y (2013). "BRCA ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357. PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ...
List of MeSH codes (D04)
... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ... pyrene MeSH D04.615.799.306.400 - dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 - 7,8-dihydro-7,8-dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 - methylcholanthrene MeSH D04.615.149.700 - perylene MeSH D04.615.181.384 ...
UPF0488 - Wikipedia
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... "C8orf33 chromosome 8 open reading frame 33 [Homo sapiens]". Entrez Gene. Ma C, Chen HI, Flores M, Huang Y, Chen Y (2013). "BRCA ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357. PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ...
CYP1A1 gene polymorphisms as a risk factor for pterygium<...
... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ...
PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts : Sussex Research Online
Online Medical Dictionary: 7
3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one ... pyrene 9,10-oxide. *7,8-Dihydroneopterintriphosphate Synthetase ... 4 benzodiazepin 2 amine 4 oxide ... Online Medical Dictionary: 7. This is the entry page of medical ... 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide ... terms started with 7. Please click to navigate more by the ... 7 Chloro 7 deoxylincomycin. *7 Chloro N methyl 5 phenyl 3H 1, ... Further Alphabetical Sectioning for Medical Terms: 7. *7*. *7a ...
Embryotoxicity of benzo(a)pyrene and some of its synthetic derivatives in Swiss mice<...
We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α-dihydroxy-9 ... N2 - We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α- ... AB - We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α- ... abstract = "We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α ...
One-electron oxidation of a pyrenyl photosensitizer covalently attached to dna and competition between its further oxidation...
Publication Detail
... pyrene (BP). Addition of (bi)sulfite to incubations containing BP-7,8-diol and an active peroxidase resulted in significantly ... pyrene (BP-7,8-diol) was examined. Both horseradish peroxidase and prostaglandin peroxidase catalyze the one-electron oxidation ... pyrene 9,10-oxide; Animals; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes*; Free Radicals; Horseradish ... This (bi)sulfite-derived peroxyl radical then reacts with BP-7,8-diol to form BP-7,8-diol-9,10-epoxides, the ultimate ...
Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10...
Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10- ... Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10- ... High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1 ... Detection of Benzo[a]pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem ...
MeSH Browser
... pyrene Anti-BaPDE BPDE Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Benzo(a)pyrene-7,8-diol 9,10-Epoxide Pharm Action. ... Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Term UI T044195. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Benzo(a)pyrene-7,8-diol 9,10-Epoxide Term UI T044196. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Pyrenes [D04.615.799] * Benzopyrenes [D04.615.799.306] * Dihydroxydihydrobenzopyrenes [D04.615.799.306.400] * 7,8-Dihydro-7,8- ...
MeSH Browser
... pyrene Anti-BaPDE BPDE Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Benzo(a)pyrene-7,8-diol 9,10-Epoxide Pharm Action. ... Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Term UI T044195. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Benzo(a)pyrene-7,8-diol 9,10-Epoxide Term UI T044196. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Pyrenes [D04.615.799] * Benzopyrenes [D04.615.799.306] * Dihydroxydihydrobenzopyrenes [D04.615.799.306.400] * 7,8-Dihydro-7,8- ...
NDF-RT Code NDF-RT Name
Oxide Synthase N0000167838 Nitric Oxide Synthase Type I N0000167839 Nitric Oxide Synthase Type II N0000167837 Nitric Oxide ... pyrene 9,10-oxide N0000167869 7-Alkoxycoumarin O-Dealkylase N0000168572 8,11,14-Eicosatrienoic Acid N0000170820 8-Bromo Cyclic ... 4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester N0000166552 4,4-Diisothiocyanostilbene-2,2- ... Cation Channels N0000170595 Cyclic Nucleotide-Regulated Protein Kinases N0000167036 Cyclic P-Oxides N0000167037 Cyclic S-Oxides ...
Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-β<sub>2</sub>...
Song, S., Lippman, S. M., Zou, Y., Ye, X., Ajani, J. A., & Xu, X. C. (2005). Induction of cyclooxygenase-2 by benzo[a]pyrene ... Song, S, Lippman, SM, Zou, Y, Ye, X, Ajani, JA & Xu, XC 2005, Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide ... N2 - Benzo[a]pyrene diol epoxide (BPDE, a carcinogen present in tobacco smoke and environmental pollution) has been shown to ... AB - Benzo[a]pyrene diol epoxide (BPDE, a carcinogen present in tobacco smoke and environmental pollution) has been shown to ...
Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol...
Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol ... Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol ... Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol ... T1 - Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene ...
Androstanols. Medical search
Ten patients received a single dose of 0.6 mg/kg rocuronium (Group I). The others received either 0.015 mg/kg pancuronium ( ... Anesthesia was induced with thiopental and fentanyl and maintained with nitrous oxide (65%) in oxygen and end-tidal isoflurane ... pyrene 9,10-oxide. 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic ... One hundred and ten minutes after the bolus of cisatracurium, four responses to the TOF were recorded. At this time, the ...
MESH TREE NUMBER CHANGES - 2007 MeSH. September 14, 2006
... pyrene 9,10-oxide D2.455.426.559.847.799.306.400.350 8,11,14-Eicosatrienoic Acid D10.251.355.255.74 D10.251.355.255.207 8-Bromo ... D3.383.742.680.705.950 Zinc Oxide-Eugenol Cement J1.637.51.339.291.925 Zinc Phosphate Cement J1.637.51.339.291.950 Zinostatin ... J1.637.51.720.830 Pyrenes D2.455.426.559.847.799 Pyrimidine Dimers D3.383.742.686.600 Pyrimidine Nucleosides D3.383.742.680 ... pyrene D2.455.426.559.847.799.306.300 Benzocycloheptenes D2.455.426.559.847.181 Benzomorphans D3.132.610.422.106 D3.132.577.249 ...
Design and Rationale of the Biomarker Center of the Household Air Pollution Intervention Network (HAPIN) Trial | Environmental...
Persistence of benzo[a]pyrene and 7,8-dihydro-7,8-dihydroxybenzo[a] pyrene in Fischer 344 rats: time distribution of total ... Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific ... Environ Health 10(suppl 1):S3, PMID: 21489213, 10.1186/1476-069X-10-S1-S3. Crossref, Medline, Google Scholar ... PLoS One 9(10):e108854, PMID: 25329995, 10.1371/journal.pone.0108854. Crossref, Medline, Google Scholar ...
Metabolite1
- BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. (elsevier.com)
Benzo2
- This (bi)sulfite-derived peroxyl radical then reacts with BP-7,8-diol to form BP-7,8-diol-9,10-epoxides, the ultimate carcinogenic form of benzo[a]pyrene (BP). (nih.gov)
- Benzo[a]pyrene diol epoxide (BPDE, a carcinogen present in tobacco smoke and environmental pollution) has been shown to suppress retinoic acid receptor-beta2 (RAR-β 2 ) and induce cyclooxygenase-2 (COX-2) expression. (elsevier.com)
Epoxide1
- Addition of (bi)sulfite to incubations containing BP-7,8-diol and an active peroxidase resulted in significantly increased levels of BP diol-epoxide formation. (nih.gov)
BPDE1
- d(GAGAGTGTACATGTGA), where [G*] is the adducted guanine residue (+)-trans-anti-BPDE-N 2 -dG (anti-BPDE = 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). (nyu.edu)
Medicine1
- 7 Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 50038 Hradec Kralove, Czech Republic. (nih.gov)