Benzopyrenes: A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Pyrenes: A group of condensed ring hydrocarbons.Sphingosine N-Acyltransferase: An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.BenzothiepinsPteridines: Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.BenzoxepinsOxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Dihydroxydihydrobenzopyrenes: Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Benzopyrene Hydroxylase: A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Sulfur Isotopes: Stable sulfur atoms that have the same atomic number as the element sulfur, but differ in atomic weight. S-33, 34, and 36 are stable sulfur isotopes.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Spindle Apparatus: A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Nitric Oxide Synthase Type I: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Spontaneous Combustion: A circumstance where a substance or organism takes fire and burns without an exogenous source. Spontaneous human combustion differs from preternatural human combustibility in that in the latter, some spark or trivial flame sets the fire and the body tissues, which have a greatly enhanced inflammability, continue to undergo incineration without any external heat source or combustible materials. (Bergman NA. Spontaneous human combustion: its role in literature and science. Pharos 1988;Fall;51(4):18-21)Rosa: A plant genus in the family ROSACEAE and order Rosales. This should not be confused with the genus RHODIOLA which is sometimes called roseroot.Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.Smith-Magenis Syndrome: Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Clofibrate: A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.Nanotubes, Carbon: Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Ethyl Methanesulfonate: An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Environmental Pollutants: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.Alkylating Agents: Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Internal Medicine: A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
UPF0488... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357 . PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ... 9 (6): 358-61. doi:10.1038/tpj.2009.47. PMC 2945913 . PMID 19841640. "C8orf33 tissue". The Human Protein Atlas. Goldstein RS, ...
... pyrene 9,10-oxide MeSH D04.615.885.120 --- buspirone MeSH D04.615.885.345 --- fluorescamine MeSH D04.615.885.347 --- ... pyrene MeSH D04.615.799.306.400 --- dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 --- 7,8-dihydro-7,8- ... dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ...
To name compounds containing phenyl groups, the phenyl group can be taken to be the parent hydrocarbon and being represented by the suffix "-benzene". Alternatively, the phenyl group could be treated as the substituent, being described within the name as "phenyl". This is usually done when the group attached to the phenyl group consists of six or more carbon atoms.[3]. As an example, consider a hydroxyl group connected to a phenyl group. In this case, if the phenyl group was taken as the parent hydrocarbon, the compound would be named hydroxybenzene. Alternatively, and more commonly, the hydroxyl group could be taken as the parent group (and the phenyl group treated as the substituent), resulting in the more familiar name phenol. ...
95%) bound to plasma proteins. Terminal half-life is 16 hours; 65% of the substance are found in the urine and 20% in the faeces, mainly in form of an acetic acid derivative (which is not detectable in the plasma), but also other water-soluble metabolites, which are urea derivatives. Less than 1% is excreted in form of the original compound. Brivudine 5'-triphosphate, the active metabolite Bromovinyluracil (BVU), the main inactive metabolite The acetic acid derivative predominantly found in urine The molecule has three chiral carbon atoms in the deoxyribose (sugar) part all of which have defined orientation; i.e. the drug is stereochemically pure. The substance is a white powder. Main supplier is Berlin-Chemie, now part of Italy's Menarini Group. In Central America is provided by Menarini Centro America and Wyeth.[citation needed] The substance was first synthesized by scientists at the University of Birmingham in the UK in 1976. It was shown to be a potent inhibitor of HSV-1 and VZV by Erik De ...
BaP's metabolites are mutagenic and highly carcinogenic, and it is listed as a Group 1 carcinogen by the IARC. Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [15] In June 2016, BaP was added as benzo[def]chrysene to the REACH Candidate List of Substances of very high concern for Authorisation.[16] Numerous studies since the 1970s have documented links between BaP and cancers.[17] It has been more difficult to link cancers to specific BaP sources, especially in humans, and difficult to quantify risks posed by various methods of exposure (inhalation or ingestion).[18] A link between vitamin A deficiency and emphysema in smokers was described in 2005 to be due to BaP, which induces vitamin A deficiency in rats.[19] A 1996 study provided molecular evidence linking components in tobacco smoke to lung cancer. BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant ...
BaP's metabolites are mutagenic and highly carcinogenic, and it is listed as a Group 1 carcinogen by the IARC. Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [13] In June 2016, BaP was added as benzo[def]chrysene to the REACH Candidate List of Substances of very high concern for Authorisation.[14] Numerous studies since the 1970s have documented links between BaP and cancers.[15] It has been more difficult to link cancers to specific BaP sources, especially in humans, and difficult to quantify risks posed by various methods of exposure (inhalation or ingestion).[citation needed] A link between vitamin A deficiency and emphysema in smokers was described in 2005 to be due to BaP, which induces vitamin A deficiency in rats.[16] A 1996 study provided molecular evidence linking components in tobacco smoke to lung cancer. BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most ...
அசிட்டோனைடு என்பது கரிம வேதியியலில், அசிட்டோன் மற்றும் டையால் -ன் வளைய கீட்டைல் அமைப்பு சேர்ந்து உருவான ஒரு வினைசெயல் தொகுதி. இந்த அமைப்பிற்கான திட்டமிடப்பட்ட பெயர் ஐசோபுரபைலிடீன் கீடைல் ஆகும். இது 1,2- மற்றும் 1,3-diols[1] க்கு மிகவும் பொதுவான பாதுகாக்கும் தொகுதி.கீட்டைல் தொகுதியை நீர்த்த அமிலங்களைக் கொண்டு நீராற்பகுக்கும் போது பாதுகாப்பு தொகுதியை[2] நீக்க முடியும்.. ...
அசிட்டோனைடு என்பது கரிம வேதியியலில், அசிட்டோன் மற்றும் டையால் -ன் வளைய கீட்டைல் அமைப்பு சேர்ந்து உருவான ஒரு வினைசெயல் தொகுதி. இந்த அமைப்பிற்கான திட்டமிடப்பட்ட பெயர் ஐசோபுரபைலிடீன் கீடைல் ஆகும். இது 1,2- மற்றும் 1,3-diols[1] க்கு மிகவும் பொதுவான பாதுகாக்கும் தொகுதி.கீட்டைல் தொகுதியை நீர்த்த அமிலங்களைக் கொண்டு நீராற்பகுக்கும் போது பாதுகாப்பு தொகுதியை[2] நீக்க முடியும்.. ...
BaP's metabolites are mutagenic and highly carcinogenic, and it is listed as a Group 1 carcinogen by the IARC. Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [15] In June 2016, BaP was added as benzo[def]chrysene to the REACH Candidate List of Substances of very high concern for Authorisation.[16] Numerous studies since the 1970s have documented links between BaP and cancers.[17] It has been more difficult to link cancers to specific BaP sources, especially in humans, and difficult to quantify risks posed by various methods of exposure (inhalation or ingestion).[18] A link between vitamin A deficiency and emphysema in smokers was described in 2005 to be due to BaP, which induces vitamin A deficiency in rats.[19] A 1996 study provided molecular evidence linking components in tobacco smoke to lung cancer. BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant ...
BaP's metabolites are mutagenic and highly carcinogenic, and it is listed as a Group 1 carcinogen by the IARC. Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [13] In June 2016, BaP was added as benzo[def]chrysene to the REACH Candidate List of Substances of very high concern for Authorisation.[14] Numerous studies since the 1970s have documented links between BaP and cancers.[15] It has been more difficult to link cancers to specific BaP sources, especially in humans, and difficult to quantify risks posed by various methods of exposure (inhalation or ingestion).[citation needed] A link between vitamin A deficiency and emphysema in smokers was described in 2005 to be due to BaP, which induces vitamin A deficiency in rats.[16] A 1996 study provided molecular evidence linking components in tobacco smoke to lung cancer. BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most ...
... (Persian: عبدل ابادپايين, also Romanized as 'Abdolābād-e Pā'īn; also known as 'Abdollāhābād and 'Abbdollāhābād)[1] is a village in Jafarabad Rural District, Jafarabad District, Qom County, Qom Province, Iran. At the 2006 census, its population was 19, in 4 families.[2] ...
U eukaryotov mnohobunkovosť vznikla niekoľkokrát nezávisle od seba, zvlášť u živočíchov, rastlín, húb a mnohých ďalších eukaryotických taxónov.[37] Vznik (respektíve vzniky) mnohobunkovosti bol značným evolučným úspechom eukaryotov. Vyriešená bola napríklad otázka vzájomného dorozumievania buniek a vzájomnej deľby práce.[38] U mnohobunkových živočíchov sú unikátne nielen gény zaisťujúce správny embryonálny vývoj (napr. hox gény), ale aj gény zaisťujúce komunikáciu medzi bunkami. U mnohobunkovcov sa vyskytujú aj nové bunkové štruktúry nepozorované u jednobunkovcov (dezmozómy a iné bunkové spoje).[39]. Najstaršie mnohobunkové živočíchy, ktoré sú dnes známe, žili v období ediakara niekedy pred 570 - 550 miliónmi rokov,[39] ako napovedajú aj niektoré údaje z molekulárnej biológie. Zreteľnejší fosílny záznam sa však objavuje až v kambriu. Z tohto obdobia, označovaného aj ako kambrická explózia druhov, pochádza ...
U eukaryotov mnohobunkovosť vznikla niekoľkokrát nezávisle od seba, zvlášť u živočíchov, rastlín, húb a mnohých ďalších eukaryotických taxónov.[36] Vznik (respektíve vzniky) mnohobunkovosti bol značným evolučným úspechom eukaryotov. Vyriešená bola napríklad otázka vzájomného dorozumievania buniek a vzájomnej deľby práce.[37] U mnohobunkových živočíchov sú unikátne nielen gény zaisťujúce správny embryonálny vývoj (napr. hox gény), ale aj gény zaisťujúce komunikáciu medzi bunkami. U mnohobunkovcov sa vyskytujú aj nové bunkové štruktúry nepozorované u jednobunkovcov (dezmozómy a iné bunkové spoje).[38] Najstaršie mnohobunkové živočíchy, ktoré sú dnes známe, žili v období ediakara niekedy pred 570 - 550 miliónmi rokov,[38] ako napovedajú aj niektoré údaje z molekulárnej biológie. Zreteľnejší fosílny záznam sa však objavuje až v kambriu. Z tohto obdobia, označovaného aj ako kambrická explózia druhov, pochádza ...
U eukaryotov mnohobunkovosť vznikla niekoľkokrát nezávisle od seba, zvlášť u živočíchov, rastlín, húb a mnohých ďalších eukaryotických taxónov.[36] Vznik (respektíve vzniky) mnohobunkovosti bol značným evolučným úspechom eukaryotov. Vyriešená bola napríklad otázka vzájomného dorozumievania buniek a vzájomnej deľby práce.[37] U mnohobunkových živočíchov sú unikátne nielen gény zaisťujúce správny embryonálny vývoj (napr. hox gény), ale aj gény zaisťujúce komunikáciu medzi bunkami. U mnohobunkovcov sa vyskytujú aj nové bunkové štruktúry nepozorované u jednobunkovcov (dezmozómy a iné bunkové spoje).[38] Najstaršie mnohobunkové živočíchy, ktoré sú dnes známe, žili v období ediakara niekedy pred 570 - 550 miliónmi rokov,[38] ako napovedajú aj niektoré údaje z molekulárnej biológie. Zreteľnejší fosílny záznam sa však objavuje až v kambriu. Z tohto obdobia, označovaného aj ako kambrická explózia druhov, pochádza ...
U eukaryotov mnohobunkovosť vznikla niekoľkokrát nezávisle od seba, zvlášť u živočíchov, rastlín, húb a mnohých ďalších eukaryotických taxónov.[36] Vznik (respektíve vzniky) mnohobunkovosti bol značným evolučným úspechom eukaryotov. Vyriešená bola napríklad otázka vzájomného dorozumievania buniek a vzájomnej deľby práce.[37] U mnohobunkových živočíchov sú unikátne nielen gény zaisťujúce správny embryonálny vývoj (napr. hox gény), ale aj gény zaisťujúce komunikáciu medzi bunkami. U mnohobunkovcov sa vyskytujú aj nové bunkové štruktúry nepozorované u jednobunkovcov (dezmozómy a iné bunkové spoje).[38] Najstaršie mnohobunkové živočíchy, ktoré sú dnes známe, žili v období ediakara niekedy pred 570 - 550 miliónmi rokov,[38] ako napovedajú aj niektoré údaje z molekulárnej biológie. Zreteľnejší fosílny záznam sa však objavuje až v kambriu. Z tohto obdobia, označovaného aj ako kambrická explózia druhov, pochádza ...
![Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAMAAAAoLQ9TAAAAA3NCSVQICAjb4U/gAAAAS1BMVEVHcExXUUVeX2MAOoUAQI0AUZRcX2MATZEAUZQAUJRdX2RgYmYAT5JfYmVfYWUATI8AUJJaXF5cXV8AKnkAT5FjZWlgYmYAVJcAVpubwa3HAAAAFXRSTlMAScNEV/iuouvgyPzG6OWNzI2WKrqT756kAAAAYUlEQVQYlWWPSxKAIAxDq4CA4l8a739SUTYZzPLN9DURaTPkLyr+dvYFWpNHCQgENHcW8AR0lgQwyIcAiYBO4gFDoHgjIoO+PIrtyUnSvUgvki6ywbXFVqpejc0485te8gCiIg4ygrdr0gAAAABJRU5ErkJggg==)
Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods... pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence ... Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods Mutat Res. 2003 Jan;543 ... pyrene (BPDE), a major ultimate carcinogen of BaP. BPDE-DNA adducts were detected in 39% of 705 samples analyzed. BPDE-protein ... pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence ...
... pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is ... 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a] ... pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is ... Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene Science. 1980 Jul 11;209( ...
Human Gene MBNL2 (ENST00000345429.10) Description and Page Index ... pyrene 9,10-oxide *D016604 Aflatoxin B1 more ... click here to view the complete list ... Position: hg38 chr13:97,276,236-97,391,336 Size: 115,101 Coding Exon Count: 8 Page Index. Sequence and Links. UniProtKB ... Position: hg38 chr13:97,222,355-97,394,120 Size: 171,766 Total Exon Count: 9 Strand: +. Coding Region. ...
... pyrene 9,10-oxide *D016604 Aflatoxin B1 more ... click here to view the complete list ... Position: mm10 chr14:120,325,239-120,428,949 Size: 103,711 Coding Exon Count: 9 Page Index. Sequence and Links. CTD. RNA ... Position: mm10 chr14:120,275,721-120,431,695 Size: 155,975 Total Exon Count: 10 Strand: +. Coding Region. ... AK028797 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732457D15 product:ZINC FINGER ...
Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).... pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. We used Affymetrix ... Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).. ... Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. ... pyrene 9,10-oxide / toxicity*. Asbestos, Serpentine / toxicity*. Bronchi / cytology, drug effects*, metabolism. Cells, Cultured ...
Analysis of liver DNA from fish exposed to benzo[a]pyrene (BP) (100 mg BP/kg fish) showed that a major DNA adduct is derived ... 0/Carcinogens; 0/DNA Adducts; 0/benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA; 55097-80-8/7,8-Dihydro-7,8-dihydroxybenzo(a) ... pyrene 9,10-oxide / analysis*, metabolism*. Carcinogens / metabolism*. DNA / analysis*, metabolism*. DNA Adducts*. Spectrometry ... pyrene diol-epoxide (BPDE). With the present limit of detection (approximately 1 adducted base per 10(8) normal base pairs for ...
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357 . PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ... 9 (6): 358-61. doi:10.1038/tpj.2009.47. PMC 2945913 . PMID 19841640. "C8orf33 tissue". The Human Protein Atlas. Goldstein RS, ...
... pyrene 9,10-oxide MeSH D04.615.885.120 --- buspirone MeSH D04.615.885.345 --- fluorescamine MeSH D04.615.885.347 --- ... pyrene MeSH D04.615.799.306.400 --- dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 --- 7,8-dihydro-7,8- ... dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ...
Ccdc47 (coiled-coil domain containing 47) - Rat Genome Databasebenzo[a]pyrene diol epoxide I increases expression. ISO. RGD:1603982. 6480464. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10- ... oxide results in increased expression of CCDC47 mRNA. CTD. PMID:20018196. bisphenol A increases expression. ISO. RGD:1308813. ... 10. 94,388,425 - 94,406,949 (-). NCBI. Rnor6.0. Rnor_6.0. rn6. Rnor6.0. Rnor_5.0. 10. 94,139,727 - 94,158,251 (-). NCBI. ... alcohol withdrawal 8 (mouse). Not determined. 11. 99363361. 122082543. Mouse. 11553867. Stmm5_m. skin tumor modifier of MSM 5 ( ...
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models. Lin, J. M., Amin, S., Trushin, N. & Hecht ... A Drosophila simulans mutant strain sensitive to benzo[a]pyrene and 2-acetylaminofluorene. Fuchs, S. Y., Safaev, R. D., ... Opposite Stereoselective Resistance to Digestion by Phosphodiesterases I and II of Benzo[a]pyrene Diol Epoxide-Modified ... Amin, S., Desai, D. & Hecht, S. S., Oct 1 1993, In : Carcinogenesis. 14, 10, p. 2033-2037 5 p.. Research output: Contribution ...
Robert (Stephen) Lloyd - Fingerprint
- Oregon Health & Science UniversityFingerprint Dive into the research topics where Robert (Stephen) Lloyd is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Screening for genotoxicity using the DRAG assay : investigation of halogenated environmental contaminants.... pyrene 9;10-oxide/chemistry/metabolism/toxicity, Alkylating Agents/chemistry/metabolism/toxicity, Animals, Biological Assay, ...
Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among...2008 Aug;17(8):2062-9. doi: 10.1158/1055-9965.EPI-08-0308. Research Support, N.I.H., Extramural; Research Support, Non-U.S. ... Mutagen sensitivity in in vitro cultured lymphocytes challenged by benzo[a]pyrene diolepoxide (BPDE) has been validated as an ... Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2062-9. doi: 10.1158/1055-9965.EPI-08-0308. ...
Pediatrics<...Tomlinson, G., Garner, H., Coombes, K. R., Xifeng, W., Roth, J., Yang, X., Shay, J. W., Wistuba, I. I., Scaglioni, P., Cinciripini, P. M., Kavanaugh, D., Gazdar, A., Atkinson, E. N., Kurie, J. & Minna, J.. National Institutes of Health. 9/30/96 → 8/31/19. Project: Research project ...
Internal Medicine - Research Output
- OSU Center for Health Sciences Research ProfilesMechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: Studies of enzyme inhibition, ... Austin, J., Smith, C., Natarajan, K., Som, M., Wayant, C. & Vassar, M., 1 Apr 2019, In : Clinical obesity. 9, 2, p. e12292. ... Edwards, E., Wayant, C., Besas, J., Chronister, J. & Vassar, M., Sep 2018, In : Chest. 154, 3, p. 512-520 9 p.. Research output ... Stevens, V. M., Neel, J. L. & Baker, D. L., 13 Nov 2000, In : AIDS Reader. 10, 10, p. 596-601 6 p.. Research output: ...
keywords = "Benzo(a)pyrene, GNMT, Phosphorylation",. author = "Yang, {Ming Hui} and Liao, {Chen Chung} and Hung, {Jung Hsien} ... Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in ... Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in ... Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in ...
Equol: A comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and...... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ...
Stephen S Hecht - Fingerprint
- Fingerprint The Fingerprint is created by mining the titles and abstracts of the persons research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri. ...
N6-(2-deoxypentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine ...
... pyrene 9,10-oxide Molecular Conformation Nucleic Acid Conformation ...
Purpose: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form ... N2 - Purpose: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to ... AB - Purpose: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to ... abstract = "Purpose: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks ...
These substrates contain adducts of (6-4) photoproducts, N-acetyl-2-aminofluorene-, 1-amino-pyrene-, BPDE (benzo[a]pyrene diol ... These substrates contain adducts of (6-4) photoproducts, N-acetyl-2-aminofluorene-, 1-amino-pyrene-, BPDE (benzo[a]pyrene diol ... These substrates contain adducts of (6-4) photoproducts, N-acetyl-2-aminofluorene-, 1-amino-pyrene-, BPDE (benzo[a]pyrene diol ... These substrates contain adducts of (6-4) photoproducts, N-acetyl-2-aminofluorene-, 1-amino-pyrene-, BPDE (benzo[a]pyrene diol ...
... pyrene 9,10-oxide *D001564 Benzo(a)pyrene *C099555 CD 437 ... 8. CDS single in 3 UTR: no RNA size: 1574. ORF size: 1119. CDS ... M24096 - Human MHC class I HLA-C-alpha-2 chain mRNA, partial cds, clone 9.. M24097 - Human MHC class I HLA-C-alpha-2 chain and ... M84171 - Human MHC class I (HLA-Cw1.2) mRNA exons 1-7, complete cds.. M84173 - Human MHC class I (HLA-Cw8.2) mRNA exons 1-7, ... M84174 - Human MHC class I (HLA-Cw8.1) mRNA exons 1-7, complete cds.. M84386 - Human MHC class I lymphocyte antigen (HLA-Cw* ...
... pyrene 9,10-oxide *D001241 Aspirin *D002945 Cisplatin *D016572 Cyclosporine ... The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 ...
D001564 Benzo(a)pyrene *D016572 Cyclosporine *C016403 2,4-dinitrotoluene *D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10- ... Position: hg19 chr12:19,592,634-19,671,654 Size: 79,021 Coding Exon Count: 9 Page Index. Sequence and Links. UniProtKB Comments ... Position: hg19 chr12:19,592,608-19,675,173 Size: 82,566 Total Exon Count: 9 Strand: +. Coding Region. ... May interact with and stimulate the activity of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3. ...
- We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. (nih.gov)
- When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. (nih.gov)
- Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE). (biomedsearch.com)
- Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. (biomedsearch.com)
- FLNS possesses sufficient resolution to distinguish between the major DNA adducts derived from different enantiomers of benzo[a]pyrene diol-epoxide (BPDE). (biomedsearch.com)
- Analysis of liver DNA from fish exposed to benzo[a]pyrene (BP) (100 mg BP/kg fish) showed that a major DNA adduct is derived from syn-BPDE. (biomedsearch.com)
- Mutagen sensitivity in in vitro cultured lymphocytes challenged by benzo[a]pyrene diolepoxide (BPDE) has been validated as an intrinsic susceptibility factor for several cancers. (cdc.gov)
- Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in coal tar, tobacco smoke, barbecued food and incomplete combustion of auto fuel. (elsevier.com)
- BaP recruits cytochrome P450 to transform itself into benzo(a)pyrene-7,8-diol-9,10-epoxide (B(a)PDE), which covalently interacts with DNA causing tumorigenesis. (elsevier.com)
- S-equol (1, 10, 30 mu M) was unable to prevent DNA damage in MCF-7 or MCF-10A breast cells following exposure to 2-hydroxy-4-nonenal, menadione, or benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide. (ulster.ac.uk)
- Purpose: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations. (elsevier.com)
- These substrates contain adducts of (6-4) photoproducts, N-acetyl-2-aminofluorene-, 1-amino-pyrene-, BPDE (benzo[a]pyrene diol epoxide)- and fluorescein that are different in many aspects such as molecular structure and size, DNA disruption mode (e.g. base stacking or non-stacking), as well as chemical properties. (elsevier.com)
- Kinetics of hydrolysis to tetraols and binding of benzo(a)pyrene-7,8-dihydrodiol-9,10-oxide and its tetraol derivatives to DNA. (nyu.edu)
- When the major reactive metabolite of benzo(a)pyrene, trans -7,8-dihydroxy - anti-9,10-epoxy -7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is incubated with DNA in aqueous solution at 25°C, both covalent binding and hydrolysis of anti-BPDE to its tetraols occur. (nyu.edu)
- The bulky lesion was derived from the binding of a benzo[a]pyrene diol epoxide isomer [(+)-anti-BPDE] to N 2 -guanine (G*). Four different 43-base long oligonucleotide templates were constructed with G* at a site 19 bases from the 5′-end. (nyu.edu)
- In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair phenotype that is associated with cancer risk. (duke.edu)
- Quantitative study of stereospecific binding of monoclonal antibody to anti-benzo(a)pyrene diol epoxide-N(2)-dG adducts by capillary electrophoresi. (nih.gov)
- The stereospecific binding of monoclonal antibody (mAb) 8E11 to anti-benzo(a)pyrene diol epoxide (BPDE)-dG adducts in single nucleoside, long oligonucleotide, and genomic DNA were quantitatively evaluated using noncompetitive and competitive capillary electrophoresis (CE) immunoassays. (nih.gov)
- In this study, we correlated genotype data of genes involved in the nucleotide excision repair pathway with mutagen sensitivity phenotype, quantified by benzo(a)pyrene diol epoxide (BPDE)-induced chromatid breaks in peripheral blood lymphocytes in 422 healthy subjects recruited into a twin study that included 138 pairs of monozygotic twins, 51 pairs of dizygotic twins, and 44 siblings. (cdc.gov)
- In order to determine the organ specific carcinogenicity of benzo(a)pyrene (B(a)P), its metabolites, formed in vitro by incubation with the homogenates from liver, lungs, kidneys, intestine and brain of rats, were isolated by TLC and spectroscopy. (bvsalud.org)
- In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 mRNA levels in breast cancer MCF-7 cells. (elsevier.com)
- The results showed that the proximate carcinogenic metabolite, 7,8-dihydro-7,8-dihydroxy B(a)P was formed only when rat lung and kidney homogenates were incubated with B(a)P in vitro. (bvsalud.org)
- Conversely, treatment with the B[a]P metabolite 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) repressed BRCA-1 promoter activity and protein, while increasing p53 and p21 protein levels. (elsevier.com)
- AK028797 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732457D15 product:ZINC FINGER PROTEIN homolog [Homo sapiens], full insert sequence. (ucsc.edu)
- AK085709 - Mus musculus 10 days lactation, adult female mammary gland cDNA, RIKEN full-length enriched library, clone:D730020H24 product:ZINC FINGER PROTEIN homolog [Homo sapiens], full insert sequence. (ucsc.edu)
- Real Time PCR for IL-8, ATF-3, GADD45B, CXC Ligand 1, and CTGF compared to GAPDH validated microarray findings at 24 h. (biomedsearch.com)
- The aromatic hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is not metabolized, did not affect BRCA-1 promoter activity or the cellular levels of BRCA-1 and p53 protein, but it did induce a CYP1A1-like promoter. (elsevier.com)
- The heavy chain is approximately 45 kDa and its gene contains 8 exons. (usc.edu)
- Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. (usc.edu)
- Promoter methylation of RARbeta and P53 mutations of exons 5 through 9 in 198 resected primary NSCLC tissues were determined by methylation-specific PCR and direct sequencing. (bvsalud.org)
- The mAb 8E11 also displays high affinity with BPDE-dG adducts in genomic DNA (K(b): 3.74 x 10(8) M(-1)), indicating its promising applications for sensitive immuno-detection of BPDE-DNA adducts in genomic DNA. (nih.gov)
- GSTM1 null genotype individuals with BPDE-DNA level higher than 5 adducts/10(8) nucleotide have increased risk of lung cancer (OR= 1.988, 95%CI: 1.011-3.912). (bvsalud.org)
- UPF0488 is a protein that in humans is encoded by the C8orf33 (Chromosome 8 Open Reading Frame 33) gene. (wikipedia.org)
- Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. (wikipedia.org)
- Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 inactivation. (nih.gov)
- lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following exposure to 2-hydroxy-4-nonenal or menadione. (ulster.ac.uk)
- Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells. (nih.gov)
- interaction of rmEMMPRINex with U937 cells leads to inhibition of MCT1 membrane expression, intracellular activation of procaspase-9, followed by DNA fragmentation and apoptosis. (nih.gov)
- Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. (nih.gov)
- Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. (nih.gov)
- Levels of caspase-9, caspase-10, MAVS, and pIRF7 in mononuclear cells and the disease activity index (SLEDAI) in the systemic lupus erythematosus patients were determined. (nih.gov)
- caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. (nih.gov)
- HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation. (nih.gov)
- Using liquid chromatography coupled with tandem mass spectrometry, this study identified serine 9 of GNMT as the phosphorylation site upon BaP treatment. (elsevier.com)
- With the present limit of detection (approximately 1 adducted base per 10(8) normal base pairs for 100 micrograms of DNA), the technique is applicable to in vivo samples. (biomedsearch.com)