Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Benzopyrenes7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideBenzo(a)pyrenePyrenesSphingosine N-AcyltransferaseBenzothiepinsPteridinesNitric Oxide SynthaseBenzoxepinsOxidoreductasesLeukotriene B4CeramidesDihydroxydihydrobenzopyrenesMolecular StructureStereoisomerismNitric Oxide Synthase Type IIOxidesBenzopyrene HydroxylaseOxidation-ReductionChromatography, High Pressure LiquidChemistrySpectrophotometry, UltravioletNitric Oxide Synthase Type IIIPolycyclic Hydrocarbons, AromaticDNA AdductsPolycyclic CompoundsCarcinogensMass SpectrometryNitric Oxide Synthase Type IBiotransformationMutagensSubstrate SpecificityNitrogen OxidesEpoxy CompoundsZinc Oxide
Benzopyrenes
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
Benzo(a)pyrene
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
Pyrenes
A group of condensed ring hydrocarbons.
Sphingosine N-Acyltransferase
An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.
Benzothiepins
Pteridines
Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.
Nitric Oxide Synthase
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Benzoxepins
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Leukotriene B4
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
Ceramides
Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.
Dihydroxydihydrobenzopyrenes
Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Nitric Oxide Synthase Type II
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Oxides
Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.
Benzopyrene Hydroxylase
A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Chemistry
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Spectrophotometry, Ultraviolet
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Nitric Oxide Synthase Type III
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
DNA Adducts
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Polycyclic Compounds
Compounds consisting of two or more fused ring structures.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Mass Spectrometry
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Nitric Oxide Synthase Type I
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Nitrogen Oxides
Inorganic oxides that contain nitrogen.
Epoxy Compounds
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
Zinc Oxide
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
UPF0488UPF0488
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... "C8orf33 chromosome 8 open reading frame 33 [Homo sapiens]". Entrez Gene. Ma C, Chen HI, Flores M, Huang Y, Chen Y (2013). "BRCA ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357. PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ...
https://en.wikipedia.org/wiki/UPF0488
List of MeSH codes (D04)List of MeSH codes (D04)
... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ... pyrene MeSH D04.615.799.306.400 - dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 - 7,8-dihydro-7,8-dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 - methylcholanthrene MeSH D04.615.149.700 - perylene MeSH D04.615.181.384 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)
UPF0488 - WikipediaUPF0488 - Wikipedia
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... "C8orf33 chromosome 8 open reading frame 33 [Homo sapiens]". Entrez Gene. Ma C, Chen HI, Flores M, Huang Y, Chen Y (2013). "BRCA ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357. PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ...
https://en.wikipedia.org/wiki/UPF0488
CYP1A1 gene polymorphisms as a risk factor for pterygium<...
... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ... pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Our previous report indicated ...
https://tmu.pure.elsevier.com/en/publications/cyp1a1-gene-polymorphisms-as-a-risk-factor-for-pterygium
PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts : Sussex Research OnlinePrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts : Sussex Research Online
4-Nitroquinoline-1-oxide, 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide, Benz(a)Anthracenes, Cell Line, DNA Adducts, DNA ... Official URL: https://doi.org/10.1038/s41467-020-19570-7 Abstract. Stalled replication forks can be restarted and repaired by ...
http://sro.sussex.ac.uk/id/eprint/101285/
Online Medical Dictionary: 7Online Medical Dictionary: 7
3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one ... pyrene 9,10-oxide. *7,8-Dihydroneopterintriphosphate Synthetase ... 4 benzodiazepin 2 amine 4 oxide ... Online Medical Dictionary: 7. This is the entry page of medical ... 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide ... terms started with 7. Please click to navigate more by the ... 7 Chloro 7 deoxylincomycin. *7 Chloro N methyl 5 phenyl 3H 1, ... Further Alphabetical Sectioning for Medical Terms: 7. *7*. *7a ...
http://meddict.charmhtml.com/initial/7
Embryotoxicity of benzo(a)pyrene and some of its synthetic derivatives in Swiss mice<...
We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α-dihydroxy-9 ... N2 - We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α- ... AB - We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α- ... abstract = "We have studied the teratogenicity of benzo(a)pyrene (BP), benzo(a)pyrene-4,5-oxide, and a racemic mixture of 7β,8α ...
https://moh-it.pure.elsevier.com/en/publications/embryotoxicity-of-benzoapyrene-and-some-of-its-synthetic-derivati
One-electron oxidation of a pyrenyl photosensitizer covalently attached to dna and competition between its further oxidation...
Publication Detail
... pyrene (BP). Addition of (bi)sulfite to incubations containing BP-7,8-diol and an active peroxidase resulted in significantly ... pyrene (BP-7,8-diol) was examined. Both horseradish peroxidase and prostaglandin peroxidase catalyze the one-electron oxidation ... pyrene 9,10-oxide; Animals; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes*; Free Radicals; Horseradish ... This (bi)sulfite-derived peroxyl radical then reacts with BP-7,8-diol to form BP-7,8-diol-9,10-epoxides, the ultimate ...
https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=1017026
Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10...Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10...
Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10- ... Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10- ... High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1 ... Detection of Benzo[a]pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem ...
https://pubmed.ncbi.nlm.nih.gov/27188524
MeSH BrowserMeSH Browser
... pyrene Anti-BaPDE BPDE Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Benzo(a)pyrene-7,8-diol 9,10-Epoxide Pharm Action. ... Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Term UI T044195. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Benzo(a)pyrene-7,8-diol 9,10-Epoxide Term UI T044196. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Pyrenes [D04.615.799] * Benzopyrenes [D04.615.799.306] * Dihydroxydihydrobenzopyrenes [D04.615.799.306.400] * 7,8-Dihydro-7,8- ...
https://meshb.nlm.nih.gov/record/ui?ui=D015123
MeSH BrowserMeSH Browser
... pyrene Anti-BaPDE BPDE Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Benzo(a)pyrene-7,8-diol 9,10-Epoxide Pharm Action. ... Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Term UI T044195. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Benzo(a)pyrene-7,8-diol 9,10-Epoxide Term UI T044196. Date04/09/1986. LexicalTag NON. ThesaurusID UNK (19XX). ... Pyrenes [D04.615.799] * Benzopyrenes [D04.615.799.306] * Dihydroxydihydrobenzopyrenes [D04.615.799.306.400] * 7,8-Dihydro-7,8- ...
https://meshb-prev.nlm.nih.gov/record/ui?ui=D015123
NDF-RT Code NDF-RT NameNDF-RT Code NDF-RT Name
Oxide Synthase N0000167838 Nitric Oxide Synthase Type I N0000167839 Nitric Oxide Synthase Type II N0000167837 Nitric Oxide ... pyrene 9,10-oxide N0000167869 7-Alkoxycoumarin O-Dealkylase N0000168572 8,11,14-Eicosatrienoic Acid N0000170820 8-Bromo Cyclic ... 4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester N0000166552 4,4-Diisothiocyanostilbene-2,2- ... Cation Channels N0000170595 Cyclic Nucleotide-Regulated Protein Kinases N0000167036 Cyclic P-Oxides N0000167037 Cyclic S-Oxides ...
https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202012-06-04.txt
Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-β<sub>2</sub>...Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-β<sub>2</sub>...
Song, S., Lippman, S. M., Zou, Y., Ye, X., Ajani, J. A., & Xu, X. C. (2005). Induction of cyclooxygenase-2 by benzo[a]pyrene ... Song, S, Lippman, SM, Zou, Y, Ye, X, Ajani, JA & Xu, XC 2005, Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide ... N2 - Benzo[a]pyrene diol epoxide (BPDE, a carcinogen present in tobacco smoke and environmental pollution) has been shown to ... AB - Benzo[a]pyrene diol epoxide (BPDE, a carcinogen present in tobacco smoke and environmental pollution) has been shown to ...
https://einstein.pure.elsevier.com/en/publications/induction-of-cyclooxygenase-2-by-benzoapyrene-diol-epoxide-throug-2
Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol...
Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol ... Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol ... Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene Diol ... T1 - Laser Pulse-Induced Photochemical Strand Cleavage of Site-Specifically and Covalently Modified (+)-anti-Benzo[a]pyrene ...
https://nyuscholars.nyu.edu/en/publications/laser-pulse-induced-photochemical-strand-cleavage-of-site-specifi
Androstanols. Medical searchAndrostanols. Medical search
Ten patients received a single dose of 0.6 mg/kg rocuronium (Group I). The others received either 0.015 mg/kg pancuronium ( ... Anesthesia was induced with thiopental and fentanyl and maintained with nitrous oxide (65%) in oxygen and end-tidal isoflurane ... pyrene 9,10-oxide. 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic ... One hundred and ten minutes after the bolus of cisatracurium, four responses to the TOF were recorded. At this time, the ...
https://lookformedical.com/en/search/androstanols
MESH TREE NUMBER CHANGES - 2007 MeSH. September 14, 2006
... pyrene 9,10-oxide D2.455.426.559.847.799.306.400.350 8,11,14-Eicosatrienoic Acid D10.251.355.255.74 D10.251.355.255.207 8-Bromo ... D3.383.742.680.705.950 Zinc Oxide-Eugenol Cement J1.637.51.339.291.925 Zinc Phosphate Cement J1.637.51.339.291.950 Zinostatin ... J1.637.51.720.830 Pyrenes D2.455.426.559.847.799 Pyrimidine Dimers D3.383.742.686.600 Pyrimidine Nucleosides D3.383.742.680 ... pyrene D2.455.426.559.847.799.306.300 Benzocycloheptenes D2.455.426.559.847.181 Benzomorphans D3.132.610.422.106 D3.132.577.249 ...
https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/mnchg2007.txt
Design and Rationale of the Biomarker Center of the Household Air Pollution Intervention Network (HAPIN) Trial | Environmental...Design and Rationale of the Biomarker Center of the Household Air Pollution Intervention Network (HAPIN) Trial | Environmental...
Persistence of benzo[a]pyrene and 7,8-dihydro-7,8-dihydroxybenzo[a] pyrene in Fischer 344 rats: time distribution of total ... Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific ... Environ Health 10(suppl 1):S3, PMID: 21489213, 10.1186/1476-069X-10-S1-S3. Crossref, Medline, Google Scholar ... PLoS One 9(10):e108854, PMID: 25329995, 10.1371/journal.pone.0108854. Crossref, Medline, Google Scholar ...
https://ehp.niehs.nih.gov/doi/references/10.1289/EHP5751
MetaboliteBenzoEpoxideBPDEMedicine
Metabolite1
  • BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. (elsevier.com)
Benzo2
  • This (bi)sulfite-derived peroxyl radical then reacts with BP-7,8-diol to form BP-7,8-diol-9,10-epoxides, the ultimate carcinogenic form of benzo[a]pyrene (BP). (nih.gov)
  • Benzo[a]pyrene diol epoxide (BPDE, a carcinogen present in tobacco smoke and environmental pollution) has been shown to suppress retinoic acid receptor-beta2 (RAR-β 2 ) and induce cyclooxygenase-2 (COX-2) expression. (elsevier.com)
Epoxide1
  • Addition of (bi)sulfite to incubations containing BP-7,8-diol and an active peroxidase resulted in significantly increased levels of BP diol-epoxide formation. (nih.gov)
BPDE1
  • d(GAGAGTGTACATGTGA), where [G*] is the adducted guanine residue (+)-trans-anti-BPDE-N 2 -dG (anti-BPDE = 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). (nyu.edu)
Medicine1
  • 7 Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 50038 Hradec Kralove, Czech Republic. (nih.gov)