Benzopyrenes: A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Pyrenes: A group of condensed ring hydrocarbons.Sphingosine N-Acyltransferase: An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.BenzothiepinsPteridines: Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.BenzoxepinsOxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Dihydroxydihydrobenzopyrenes: Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Benzopyrene Hydroxylase: A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Nitric Oxide Synthase Type I: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
*  UPF0488
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357 . PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ... 9 (6): 358-61. doi:10.1038/tpj.2009.47. PMC 2945913 . PMID 19841640. "C8orf33 tissue". The Human Protein Atlas. Goldstein RS, ...
*  List of MeSH codes (D04)
... pyrene 9,10-oxide MeSH D04.615.885.120 --- buspirone MeSH D04.615.885.345 --- fluorescamine MeSH D04.615.885.347 --- ... pyrene MeSH D04.615.799.306.400 --- dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 --- 7,8-dihydro-7,8- ... dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ...
Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).  Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).
... pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. We used Affymetrix ... Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).. ... Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. ... pyrene 9,10-oxide / toxicity*. Asbestos, Serpentine / toxicity*. Bronchi / cytology, drug effects*, metabolism. Cells, Cultured ...
more infohttp://www.biomedsearch.com/nih/Gene-profiling-normal-human-bronchial/18197826.html
Fluorescence line-narrowing spectrometry: a versatile tool for the study of chemically initiated carcinogenesis.  Fluorescence line-narrowing spectrometry: a versatile tool for the study of chemically initiated carcinogenesis.
Analysis of liver DNA from fish exposed to benzo[a]pyrene (BP) (100 mg BP/kg fish) showed that a major DNA adduct is derived ... 0/Carcinogens; 0/DNA Adducts; 0/benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA; 55097-80-8/7,8-Dihydro-7,8-dihydroxybenzo(a) ... pyrene 9,10-oxide / analysis*, metabolism*. Carcinogens / metabolism*. DNA / analysis*, metabolism*. DNA Adducts*. Spectrometry ... pyrene diol-epoxide (BPDE). With the present limit of detection (approximately 1 adducted base per 10(8) normal base pairs for ...
more infohttp://www.biomedsearch.com/nih/Fluorescence-line-narrowing-spectrometry-versatile/2128812.html
Ccdc47 (coiled-coil domain containing 47) - Rat Genome Database  Ccdc47 (coiled-coil domain containing 47) - Rat Genome Database
benzo[a]pyrene diol epoxide I increases expression. ISO. RGD:1603982. 6480464. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10- ... oxide results in increased expression of CCDC47 mRNA. CTD. PMID:20018196. bisphenol A increases expression. ISO. RGD:1308813. ... 10. 94,388,425 - 94,406,949 (-). NCBI. Rnor6.0. Rnor_6.0. rn6. Rnor6.0. Rnor_5.0. 10. 94,139,727 - 94,158,251 (-). NCBI. ... alcohol withdrawal 8 (mouse). Not determined. 11. 99363361. 122082543. Mouse. 11553867. Stmm5_m. skin tumor modifier of MSM 5 ( ...
more infohttp://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1331876
Pediatrics<...  Pediatrics<...
Tomlinson, G., Garner, H., Coombes, K. R., Xifeng, W., Roth, J., Yang, X., Shay, J. W., Wistuba, I. I., Scaglioni, P., Cinciripini, P. M., Kavanaugh, D., Gazdar, A., Atkinson, E. N., Kurie, J. & Minna, J.. National Institutes of Health. 9/30/96 → 8/31/19. Project: Research project ...
more infohttps://scholars.uthscsa.edu/en/organisations/pediatrics
Equol: A comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and...  Equol: A comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and...
... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ...
more infohttps://pure.ulster.ac.uk/en/publications/equol-a-comparison-of-the-effects-of-the-racemic-compound-with-th-3
Stephen S Hecht - Fingerprint
     - Experts@Minnesota  Stephen S Hecht - Fingerprint - [email protected]
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri. ...
more infohttps://experts.umn.edu/en/persons/stephen-s-hecht/fingerprints/
Human Gene HLA-C (uc011gws.2) Description and Page Index	  Human Gene HLA-C (uc011gws.2) Description and Page Index
... pyrene 9,10-oxide *D001564 Benzo(a)pyrene *C099555 CD 437 ... 8. CDS single in 3' UTR: no RNA size: 1574. ORF size: 1119. CDS ... M24096 - Human MHC class I HLA-C-alpha-2 chain mRNA, partial cds, clone 9.. M24097 - Human MHC class I HLA-C-alpha-2 chain and ... M84171 - Human MHC class I (HLA-Cw1.2) mRNA exons 1-7, complete cds.. M84173 - Human MHC class I (HLA-Cw8.2) mRNA exons 1-7, ... M84174 - Human MHC class I (HLA-Cw8.1) mRNA exons 1-7, complete cds.. M84386 - Human MHC class I lymphocyte antigen (HLA-Cw* ...
more infohttp://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011gws.2&hgg_prot=B0S7Z5&hgg_chrom=chr6_mann_hap4&hgg_start=2583420&hgg_end=2586798&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
Human Gene HLA-G (uc011gqm.3) Description and Page Index	  Human Gene HLA-G (uc011gqm.3) Description and Page Index
... pyrene 9,10-oxide *D001241 Aspirin *D002945 Cisplatin *D016572 Cyclosporine ... The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 ...
more infohttp://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011gqm.3&hgg_prot=P17693&hgg_chrom=chr6_mann_hap4&hgg_start=1096152&hgg_end=1276307&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
UPF0488 - Wikipedia  UPF0488 - Wikipedia
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357 . PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ... 9 (6): 358-61. doi:10.1038/tpj.2009.47. PMC 2945913 . PMID 19841640. "C8orf33 tissue". The Human Protein Atlas. Goldstein RS, ...
more infohttps://en.wikipedia.org/wiki/UPF0488
List of MeSH codes (D04) - Wikipedia  List of MeSH codes (D04) - Wikipedia
... pyrene 9,10-oxide MeSH D04.615.885.120 --- buspirone MeSH D04.615.885.345 --- fluorescamine MeSH D04.615.885.347 --- ... pyrene MeSH D04.615.799.306.400 --- dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 --- 7,8-dihydro-7,8- ... dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)
Screening for genotoxicity using the DRAG assay : investigation of halogenated environmental contaminants.  Screening for genotoxicity using the DRAG assay : investigation of halogenated environmental contaminants.
... pyrene 9;10-oxide/chemistry/metabolism/toxicity, Alkylating Agents/chemistry/metabolism/toxicity, Animals, Biological Assay, ...
more infohttp://su.diva-portal.org/smash/record.jsf?pid=diva2:186810
Non-covalent intercalative binding of 7,8-dihydroxy-9,10-epoxybenzo(a)pyrene to DNA<...  Non-covalent intercalative binding of 7,8-dihydroxy-9,10-epoxybenzo(a)pyrene to DNA<...
... pyrene to DNA",. abstract = "When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a) ... When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) is mixed into a ... N2 - When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) is mixed ... AB - When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE)
more infohttps://nyu-staging.pure.elsevier.com/en/publications/non-covalent-intercalative-binding-of-78-dihydroxy-910-epoxybenzo
Correlation between base-excision repair gene polymorphisms and levels of in-vitro
         BPDE-induced DNA adducts in...  Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in...
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a ... pyrene 9,10-oxide. DNA Adducts. DNA Repair. Genotype. Polymorphism, Genetic. Polymorphism, Single Nucleotide. Adult. Aged. ... PloS one, 7(7). pp. e40131. 10.1371/journal.pone.0040131. Retrieved from https://hdl.handle.net/10161/18019.. This is ...
more infohttps://dukespace.lib.duke.edu/dspace/handle/10161/18019
Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1:...  Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1:...
In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 ... In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 ... In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 ... In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 ...
more infohttps://arizona.pure.elsevier.com/en/publications/activation-of-the-aromatic-hydrocarbon-receptor-pathway-is-not-su
Quantitative study of stereospecific binding of monoclonal antibody to anti-benzo(a)pyrene diol epoxide-N(2)-dG adducts by...  Quantitative study of stereospecific binding of monoclonal antibody to anti-benzo(a)pyrene diol epoxide-N(2)-dG adducts by...
2010 Apr 9;1217(15):2254-61. doi: 10.1016/j.chroma.2010.02.024. Epub 2010 Feb 20. Research Support, Non-U.S. Gov't ... The stereospecific binding of monoclonal antibody (mAb) 8E11 to anti-benzo(a)pyrene diol epoxide (BPDE)-dG adducts in single ... Quantitative study of stereospecific binding of monoclonal antibody to anti-benzo(a)pyrene diol epoxide-N(2)-dG adducts by ... The binding of mAb 8E11 to trans-(+)-anti-BPDE-dG displays strongest affinity (K(b): 3.57 x 10(8) M(-1)) among all four ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/20223464
Search Articles | University of Toronto Libraries  Search Articles | University of Toronto Libraries
BCRP , RESVERATROL , ACTIVATION , benzo[a]pyrene , Caco-2 cells , TRANSCRIPTION , PREVENTION , phytochemicals , FLAVONOIDS , ... NITRIC-OXIDE , PERIPHERAL VASCULAR DISEASE , DYSFUNCTION , BINDING , catalase , Free Radical Scavengers - pharmacology , Cyclic ... 3. Full Text Phytochemicals Induce Breast Cancer Resistance Protein in Caco-2 Cells and Enhance the Transport of Benzo[a]pyrene ... Nitric Oxide - metabolism , Prostaglandins - metabolism , Studies , Blood vessels , Signal transduction , Enzymes , Nitric ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Hydroquinones%20-%20pharmacology
Search Articles | University of Toronto Libraries  Search Articles | University of Toronto Libraries
... pyrene 9,10-oxide - metabolism , Occupational Exposure - adverse effects , Coke , Humans , Middle Aged , Male , Biomarkers - ... Pyrenes - urine , Environmental Monitoring , Biomarkers - urine , Deoxyguanosine - urine , Oxidative Stress , 7,8-Dihydro-7,8- ... dihydroxybenzo(a) ... 8. Full Text Long-term exposure to silica dust and risk of ... 9. Full Text Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Wu,%20Tangchun
Caspase-9  Caspase-9
Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP9 protein] 1 ... 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with ... Genistein inhibits the reaction [benzo(e)pyrene results in increased activity of CASP9 protein] 1 ... pyrene 9,10-oxide results in increased cleavage of CASP9 protein] 1 ...
more infohttps://pharos.nih.gov/idg/targets/P55211
Skin Diseases - Diseases | CTD  Skin Diseases - Diseases | CTD
dihydroxybenzo(a)pyrene 9,10-oxide , 8-bromocyclic GMP , Acetylcysteine , Acitretin , Apigenin , Arsenic , arsenite , ... Dihydro-. 7,8-. dihydroxybenzo(a)pyrene 9,10-oxide , 9,10-. Dimethyl-. 1,2-. benzanthracene , Acetylcysteine , Apigenin , ... methylbutanamide , Nelfinavir , Nickel , Niclosamide , Nicotine , nimesulide , Nitric Oxide , Nitrofurazone , ochratoxin A , ... yl)amine , allyl sulfide , Arsenic Trioxide , Ascorbic Acid , Atrazine , Benzo(a)pyrene , Bexarotene , Biological Products , ...
more infohttp://ctdbase.org/detail.go?type=disease&acc=MESH%3AD012871&view=phenotype
  • Real Time PCR for IL-8, ATF-3, GADD45B, CXC Ligand 1, and CTGF compared to GAPDH validated microarray findings at 24 h. (biomedsearch.com)
  • The aromatic hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is not metabolized, did not affect BRCA-1 promoter activity or the cellular levels of BRCA-1 and p53 protein, but it did induce a CYP1A1-like promoter. (elsevier.com)
  • Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. (usc.edu)
  • The heavy chain is approximately 45 kDa and its gene contains 8 exons. (usc.edu)
  • UPF0488 is a protein that in humans is encoded by the C8orf33 (Chromosome 8 Open Reading Frame 33) gene. (wikipedia.org)
  • Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. (wikipedia.org)
  • Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. (nih.gov)
  • lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following exposure to 2-hydroxy-4-nonenal or menadione. (ulster.ac.uk)
  • Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells. (nih.gov)
  • interaction of rmEMMPRINex with U937 cells leads to inhibition of MCT1 membrane expression, intracellular activation of procaspase-9, followed by DNA fragmentation and apoptosis. (nih.gov)
  • Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. (nih.gov)
  • Levels of caspase-9, caspase-10, MAVS, and pIRF7 in mononuclear cells and the disease activity index (SLEDAI) in the systemic lupus erythematosus patients were determined. (nih.gov)
  • caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. (nih.gov)
  • Chemokines, growth-regulated oncogene-alpha (Gro-alpha, CXCL-1), and IL-8, were significantly increased, and these had previously been observed in bronchoalveolar lavage from asbestos workers or in animal models. (biomedsearch.com)
  • With the present limit of detection (approximately 1 adducted base per 10(8) normal base pairs for 100 micrograms of DNA), the technique is applicable to in vivo samples. (biomedsearch.com)
  • Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate Transporter 1 and Activation of Procaspase-9. (nih.gov)