A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of condensed ring hydrocarbons.
An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.
Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.
Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.
A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Compounds consisting of two or more fused ring structures.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Inorganic oxides that contain nitrogen.
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.
Databases devoted to knowledge about specific genes and gene products.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... "C8orf33 chromosome 8 open reading frame 33 [Homo sapiens]". Entrez Gene. Ma C, Chen HI, Flores M, Huang Y, Chen Y (2013). "BRCA ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357. PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ...
... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ... pyrene MeSH D04.615.799.306.400 - dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 - 7,8-dihydro-7,8-dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 - methylcholanthrene MeSH D04.615.149.700 - perylene MeSH D04.615.181.384 ...
... pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence ... Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods Mutat Res. 2003 Jan;543 ... pyrene (BPDE), a major ultimate carcinogen of BaP. BPDE-DNA adducts were detected in 39% of 705 samples analyzed. BPDE-protein ... pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence ...
... pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is ... 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a] ... pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is ... Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene Science. 1980 Jul 11;209( ...
... pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. We used Affymetrix ... Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).. ... Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. ... pyrene 9,10-oxide / toxicity*. Asbestos, Serpentine / toxicity*. Bronchi / cytology, drug effects*, metabolism. Cells, Cultured ...
... pyrene 9,10-oxide *D016604 Aflatoxin B1 more ... click here to view the complete list ... Position: hg38 chr13:97,276,236-97,391,336 Size: 115,101 Coding Exon Count: 8 Page Index. Sequence and Links. UniProtKB ... Position: hg38 chr13:97,222,355-97,394,120 Size: 171,766 Total Exon Count: 9 Strand: +. Coding Region. ...
... pyrene 9,10-oxide *D016604 Aflatoxin B1 more ... click here to view the complete list ... Position: mm10 chr14:120,325,239-120,428,949 Size: 103,711 Coding Exon Count: 9 Page Index. Sequence and Links. CTD. RNA ... Position: mm10 chr14:120,275,721-120,431,695 Size: 155,975 Total Exon Count: 10 Strand: +. Coding Region. ... AK028797 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732457D15 product:ZINC FINGER ...
Analysis of liver DNA from fish exposed to benzo[a]pyrene (BP) (100 mg BP/kg fish) showed that a major DNA adduct is derived ... 0/Carcinogens; 0/DNA Adducts; 0/benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA; 55097-80-8/7,8-Dihydro-7,8-dihydroxybenzo(a) ... pyrene 9,10-oxide / analysis*, metabolism*. Carcinogens / metabolism*. DNA / analysis*, metabolism*. DNA Adducts*. Spectrometry ... pyrene diol-epoxide (BPDE). With the present limit of detection (approximately 1 adducted base per 10(8) normal base pairs for ...
We found that PM greatly inhibits NER for ultraviolet (UV) light and benzo(a)pyrene diol epoxide (BPDE) induced DNA damage in ... pyrene 9,10-oxide/toxicity; Air Pollutants/toxicity*; Cell Line, Tumor; DNA Repair/drug effects*; DNA Replication; Humans; Lung ... A recent epidemiology study has established that each 10 microg/m3 elevation in long-term exposure to average PM2.5 ambient ... concentration was associated with approximately 8% of lung cancer mortality. The underlying mechanisms of how PM contributes to ...
benzo[a]pyrene diol epoxide I increases expression. ISO. RGD:1603982. 6480464. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10- ... oxide results in increased expression of CCDC47 mRNA. CTD. PMID:20018196. bisphenol A increases expression. ISO. RGD:1308813. ... 10. 94,388,425 - 94,406,949 (-). NCBI. Rnor6.0. Rnor_6.0. rn6. Rnor6.0. Rnor_5.0. 10. 94,139,727 - 94,158,251 (-). NCBI. ... alcohol withdrawal 8 (mouse). Not determined. 11. 99363361. 122082543. Mouse. 11553867. Stmm5_m. skin tumor modifier of MSM 5 ( ...
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models. Lin, J. M., Amin, S., Trushin, N. & Hecht ... A Drosophila simulans mutant strain sensitive to benzo[a]pyrene and 2-acetylaminofluorene. Fuchs, S. Y., Safaev, R. D., ... Opposite Stereoselective Resistance to Digestion by Phosphodiesterases I and II of Benzo[a]pyrene Diol Epoxide-Modified ... Amin, S., Desai, D. & Hecht, S. S., Oct 1 1993, In : Carcinogenesis. 14, 10, p. 2033-2037 5 p.. Research output: Contribution ...
... pyrene 9,10-oxide, benzo(a)pyrene, methotrexate, and vitamin E. The expression of the UPF0488 gene increases after treatment ... "C8orf33 chromosome 8 open reading frame 33 [Homo sapiens]". Entrez Gene. Ma C, Chen HI, Flores M, Huang Y, Chen Y (2013). "BRCA ... Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. The UPF0488 protein ... 7 Suppl 5: S5. doi:10.1186/1752-0509-7-S5-S5. PMC 4029357. PMID 24564956. "UPF0488 protein C8orf33 [Homo sapiens]". Entrez ...
... pyrene 9,10-oxide MeSH D04.615.885.120 - buspirone MeSH D04.615.885.345 - fluorescamine MeSH D04.615.885.347 - fluoresceins ... pyrene MeSH D04.615.799.306.400 - dihydroxydihydrobenzopyrenes MeSH D04.615.799.306.400.350 - 7,8-dihydro-7,8-dihydroxybenzo(a) ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... 9,10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 - methylcholanthrene MeSH D04.615.149.700 - perylene MeSH D04.615.181.384 ...
... pyrene (BPDE) is strongly implicated as a cause of human lung cancer. Here, we show that FOXO3a is functionally activated and ... pyrene (BPDE) is strongly implicated as a cause of human lung cancer. Here, we show that FOXO3a is functionally activated and ... pyrene (BPDE) is strongly implicated as a cause of human lung cancer. Here, we show that FOXO3a is functionally activated and ... pyrene (BPDE) is strongly implicated as a cause of human lung cancer. Here, we show that FOXO3a is functionally activated and ...
Fingerprint Dive into the research topics where Robert (Stephen) Lloyd is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Bergan, R., Casele, H., Ambre, J. J., Hendely, D., McCarthy, W., Mujais, S., Kazer, R. R., Buchanan, T. A., Piergies, A. A., Freinkel, N., Mercer, L., Pearce, W., Freinkel, R., Patterson, P., Phelps, R., Reid, G., Atkison, A., Juan, D., Craig, R. M., Rebar, R. W., Molitch, M. E., Grammer, L., Levin, M., Bakouche, O., Nanninga, J. B., Gowans, S., Atkinson, A., Tommaso, C., Robar, R. W., Gordon, K., Hantel, A., Kahrilas, P., Greenberger, P., Duda, R., Disterhoft, J., [No Value], S. J., Battle, D., Phair, J., Atkinson, A., Lindquist, J., Kaplan, B., Garcia, P., Wessel, H., Patterson, R. O. Y., Gelber, S., Beaty, H., Zull, D., Mittal, B., Kaufman, D., Pope, R., Gann, P. H., Kwaan, H., Purdy, L. P., Thomas, R., Weinberg, D., Metzger, B., Yogev, R. A. M., Goldberger, J., Smith, L., Von Roenn, J., Henthorn, T., Kuzel, T., Mendley, S., Boas, S., Grujic, Z., Blei, A., Liang, G., Gradishar, W., Fragen, R., Langman, C., Benloucif, S., Quigg, R., Charrow, J., McVary, K. T., McColley, S., Baumann, G., ...
... pyrene 9;10-oxide/chemistry/metabolism/toxicity, Alkylating Agents/chemistry/metabolism/toxicity, Animals, Biological Assay, ...
32P-Postlabeling Analysis of the DNA Adducts of 6-Fluorobenzo[a]pyrene and 6-Methylbenzo[a]pyrene Formed in Vitro. Todorovic, R ... 32P-Postlabeling Analysis of Benzo[a ]pyrene-DNA Adducts Formed in Vitro and in Vivo. Bodell, W. J., Devanesan, P. D., Rogan, E ... Hu, J., Jones, A. Y. M., Zhou, X., Zhai, H., Ngai, S. P. C., Siu, K. C. & Dalton, M., Apr 9 2020, In: BMC Medical Education. 20 ... Meyler, D., Stimpson, J. P. & Peek, M. K., Mar 2006, In: Aging and Mental Health. 10, 2, p. 182-186 5 p.. Research output: ...
... pyrene to DNA",. abstract = "When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a) ... When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) is mixed into a ... N2 - When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) is mixed ... AB - When the benzo(a)pyrene diol epoxide (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE)
2008 Aug;17(8):2062-9. doi: 10.1158/1055-9965.EPI-08-0308. Research Support, N.I.H., Extramural; Research Support, Non-U.S. ... Mutagen sensitivity in in vitro cultured lymphocytes challenged by benzo[a]pyrene diolepoxide (BPDE) has been validated as an ... Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2062-9. doi: 10.1158/1055-9965.EPI-08-0308. ...
Tomlinson, G., Garner, H., Coombes, K. R., Xifeng, W., Roth, J., Yang, X., Shay, J. W., Wistuba, I. I., Scaglioni, P., Cinciripini, P. M., Kavanaugh, D., Gazdar, A., Atkinson, E. N., Kurie, J. & Minna, J.. National Institutes of Health. 9/30/96 → 8/31/19. Project: Research project ...
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: Studies of enzyme inhibition, ... Austin, J., Smith, C., Natarajan, K., Som, M., Wayant, C. & Vassar, M., 1 Apr 2019, In : Clinical obesity. 9, 2, p. e12292. ... Edwards, E., Wayant, C., Besas, J., Chronister, J. & Vassar, M., Sep 2018, In : Chest. 154, 3, p. 512-520 9 p.. Research output ... Stevens, V. M., Neel, J. L. & Baker, D. L., 13 Nov 2000, In : AIDS Reader. 10, 10, p. 596-601 6 p.. Research output: ...
keywords = "Benzo(a)pyrene, GNMT, Phosphorylation",. author = "Yang, {Ming Hui} and Liao, {Chen Chung} and Hung, {Jung Hsien} ... Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in ... Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in ... Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in ...
benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA * DNA Adducts ... CCN6-mediated MMP-9 activation enhances metastatic potential of ... Huan, S. K. H., Lee, H. H., Liu, D. Z., Wu, C. C. & Wang, C. C., 六月 1 2006, 於: Toxicology. 223, 1-2, p. 136-143 8 p.. 研究成果: 雜誌貢 ... Chang, C-C., Tsai, Y. H., Liu, Y., Lin, S-Y. & Liang, Y-C., 十月 1 2015, 於: Rheumatology. 54, 10, p. 1913-1922 10 p.. 研究成果: 雜誌貢獻 ... Wu, S. Y., Yan, M. D., Wu, A. T. H., Yuan, K. S. P. & Liu, S. H., 2016, 於: Journal of Cancer. 7, 15, p. 2408-2419 12 p.. 研究
... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ... pyrene-7,8-dihydrodiol-9,10-epoxide. lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following ...
Fingerprint Dive into the research topics of Equol: A comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and DNA integrity of breast and prostate cells in vitro. Together they form a unique fingerprint. ...
Fingerprint The Fingerprint is created by mining the titles and abstracts of the persons research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri. ...
Solution conformation of the major adduct between the carcinogen (+)-anti- benzo[a]pyrene diol epoxide and DNA. Cosman, M., De ... Influence of Benzo[a]pyrene Diol Epoxide Chirality on Solution Conformations of DNA Covalent Adducts: The (-)-trans-anti-[BP]G. ... pyrene Adducts to Guanine-/V2 in a Duplex Dodecamer. Singh, S. B., Hingerty, B. E., Singh, U. C., Greenberg, J. P., Geacintov, ... Brody, M., Broyde, S. B., Yeh, C. C. & Brody, S. S., Aug 1 1968, In: Biochemistry. 7, 8, p. 3007-3015 9 p.. Research output: ...
D001564 Benzo(a)pyrene *C075773 4-phenylbutyric acid *D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide ... The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 ... X64879 - H.sapiens mRNA for HLA-E heavy chain (exons 4 - 7).. ... 7. CDS single in 3 UTR: no RNA size: 994. ORF size: 0. CDS ... and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a ...
... pyrene 9,10-oxide *D001564 Benzo(a)pyrene *C099555 CD 437 ... 8. CDS single in 3 UTR: no RNA size: 1574. ORF size: 1119. CDS ... M24096 - Human MHC class I HLA-C-alpha-2 chain mRNA, partial cds, clone 9.. M24097 - Human MHC class I HLA-C-alpha-2 chain and ... M84171 - Human MHC class I (HLA-Cw1.2) mRNA exons 1-7, complete cds.. M84173 - Human MHC class I (HLA-Cw8.2) mRNA exons 1-7, ... M84174 - Human MHC class I (HLA-Cw8.1) mRNA exons 1-7, complete cds.. M84386 - Human MHC class I lymphocyte antigen (HLA-Cw* ...
  • We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. (nih.gov)
  • When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. (nih.gov)
  • Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE). (biomedsearch.com)
  • Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. (biomedsearch.com)
  • FLNS possesses sufficient resolution to distinguish between the major DNA adducts derived from different enantiomers of benzo[a]pyrene diol-epoxide (BPDE). (biomedsearch.com)
  • Analysis of liver DNA from fish exposed to benzo[a]pyrene (BP) (100 mg BP/kg fish) showed that a major DNA adduct is derived from syn-BPDE. (biomedsearch.com)
  • We found that PM greatly inhibits NER for ultraviolet (UV) light and benzo(a)pyrene diol epoxide (BPDE) induced DNA damage in human lung cells. (nih.gov)
  • Mutagen sensitivity in in vitro cultured lymphocytes challenged by benzo[a]pyrene diolepoxide (BPDE) has been validated as an intrinsic susceptibility factor for several cancers. (cdc.gov)
  • Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in coal tar, tobacco smoke, barbecued food and incomplete combustion of auto fuel. (elsevier.com)
  • BaP recruits cytochrome P450 to transform itself into benzo(a)pyrene-7,8-diol-9,10-epoxide (B(a)PDE), which covalently interacts with DNA causing tumorigenesis. (elsevier.com)
  • S-equol (1, 10, 30 mu M) was unable to prevent DNA damage in MCF-7 or MCF-10A breast cells following exposure to 2-hydroxy-4-nonenal, menadione, or benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide. (ulster.ac.uk)
  • These substrates contain adducts of (6-4) photoproducts, N-acetyl-2-aminofluorene-, 1-amino-pyrene-, BPDE (benzo[a]pyrene diol epoxide)- and fluorescein that are different in many aspects such as molecular structure and size, DNA disruption mode (e.g. base stacking or non-stacking), as well as chemical properties. (elsevier.com)
  • Kinetics of hydrolysis to tetraols and binding of benzo(a)pyrene-7,8-dihydrodiol-9,10-oxide and its tetraol derivatives to DNA. (nyu.edu)
  • When the major reactive metabolite of benzo(a)pyrene, trans -7,8-dihydroxy - anti-9,10-epoxy -7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is incubated with DNA in aqueous solution at 25°C, both covalent binding and hydrolysis of anti-BPDE to its tetraols occur. (nyu.edu)
  • Preincubation of MCF-10A cells with genistein decreased the extent of DNA damage by 4-hydroxy-2-nonenal (150 mu M) and benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (50 mu M), compounds readily detoxified by hGSTA4-4 and hGSTP1-1. (elsevier.com)
  • Pool-Zobel, Beatrice L. / Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system . (elsevier.com)
  • NQO1-null mice deficient in NQO1 protein showed increased sensitivity to 7,12-dimethylbenz(a)anthracene- and benzo(a)pyrene-induced skin carcinogenesis. (houstonmethodist.org)
  • In the present studies, we show that benzo(a)pyrene metabolite benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide and not benzo(a)pyrene quinones contributed to increased benzo(a) pyrene-induced skin tumors in NQO1-null mice. (houstonmethodist.org)
  • Treatment with benzo(a)pyrene failed to significantly increase p53 and apoptosis in the skin of NQO1-null mice when compared with wild-type mice. (houstonmethodist.org)
  • These results led to the conclusion thai altered intracellular redox state along with lack of induction of p53 and decreased apoptosis plays a significant role in increased sensitivity of NQO1-null mice to benzo(a) pyrene-induced skin cancer. (houstonmethodist.org)
  • In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair phenotype that is associated with cancer risk. (duke.edu)
  • Soft agar experiment and nude mice subcutaneous injection were performed using pre-transformed 16HBE cells induced by known carcinogens , nickel sulfate (NiSO4) and 7, 8, -dihydrodiol-9, 10- epoxide benzo[a] pyrene ( BPDE ). (bvsalud.org)
  • Quantitative study of stereospecific binding of monoclonal antibody to anti-benzo(a)pyrene diol epoxide-N(2)-dG adducts by capillary electrophoresi. (nih.gov)
  • The stereospecific binding of monoclonal antibody (mAb) 8E11 to anti-benzo(a)pyrene diol epoxide (BPDE)-dG adducts in single nucleoside, long oligonucleotide, and genomic DNA were quantitatively evaluated using noncompetitive and competitive capillary electrophoresis (CE) immunoassays. (nih.gov)
  • In this study, we correlated genotype data of genes involved in the nucleotide excision repair pathway with mutagen sensitivity phenotype, quantified by benzo(a)pyrene diol epoxide (BPDE)-induced chromatid breaks in peripheral blood lymphocytes in 422 healthy subjects recruited into a twin study that included 138 pairs of monozygotic twins, 51 pairs of dizygotic twins, and 44 siblings. (cdc.gov)
  • In this study, we investigated the mechanisms through which the environmental carcinogen benzo[a]pyrene (B[a]P) lowered BRCA-1 mRNA levels in breast cancer MCF-7 cells. (elsevier.com)
  • Most studies reviewed here measured tetraols released from DNA or protein by hydrolysis of adducts derived from (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a major ultimate carcinogen of BaP. (nih.gov)
  • The carcinogen (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) is strongly implicated as a cause of human lung cancer. (elsevier.com)
  • the fluorescence of BPDE-ssDNA was significantly enhanced by up to 8-9-fold. (elsevier.com)
  • 7% of the total anti-BPDE initially present) and hydrolysis of anti-BPDE reach their maximum levels within less than five minutes after mixing. (nyu.edu)
  • 16HBETR, 16HBETM cells obtained transformed phenotype at 5 wks, 11 wks, respectively after treatment with BPDE , which are 15 wks and 9 wks earlier than control cells 16HBETV (20 wks). (bvsalud.org)
  • The mAb 8E11 also displays high affinity with BPDE-dG adducts in genomic DNA (K(b): 3.74 x 10(8) M(-1)), indicating its promising applications for sensitive immuno-detection of BPDE-DNA adducts in genomic DNA. (nih.gov)
  • Conversely, treatment with the B[a]P metabolite 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) repressed BRCA-1 promoter activity and protein, while increasing p53 and p21 protein levels. (elsevier.com)
  • AK028797 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732457D15 product:ZINC FINGER PROTEIN homolog [Homo sapiens], full insert sequence. (ucsc.edu)
  • AK085709 - Mus musculus 10 days lactation, adult female mammary gland cDNA, RIKEN full-length enriched library, clone:D730020H24 product:ZINC FINGER PROTEIN homolog [Homo sapiens], full insert sequence. (ucsc.edu)
  • Real Time PCR for IL-8, ATF-3, GADD45B, CXC Ligand 1, and CTGF compared to GAPDH validated microarray findings at 24 h. (biomedsearch.com)
  • The aromatic hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is not metabolized, did not affect BRCA-1 promoter activity or the cellular levels of BRCA-1 and p53 protein, but it did induce a CYP1A1-like promoter. (elsevier.com)
  • Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 inactivation. (nih.gov)
  • interaction of rmEMMPRINex with U937 cells leads to inhibition of MCT1 membrane expression, intracellular activation of procaspase-9, followed by DNA fragmentation and apoptosis. (nih.gov)
  • Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. (nih.gov)
  • HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation. (nih.gov)
  • Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate Transporter 1 and Activation of Procaspase-9. (nih.gov)
  • Chemokines, growth-regulated oncogene-alpha (Gro-alpha, CXCL-1), and IL-8, were significantly increased, and these had previously been observed in bronchoalveolar lavage from asbestos workers or in animal models. (biomedsearch.com)
  • Exposure to genistein significantly increased hGSTP1 mRNA (2.3-fold), hGSTP1-1 protein levels (3.1-fold), GST catalytic activity (4.7-fold) and intracellular glutathione concentrations (1.4-fold) in MCF-10A cells, whereas no effects were observed on GST expression or glutathione concentrations in MCF-7 cells. (elsevier.com)
  • lit contrast, racemic equol (10, 30 mu M) prevented DNA damage in MCF-10A cells following exposure to 2-hydroxy-4-nonenal or menadione. (ulster.ac.uk)
  • Our approach was to use human mammary cell lines MCF-10A and MCF-7 as models for non-neoplastic and neoplastic epithelial breast cells, respectively. (elsevier.com)
  • In contrast, MCF-7 cells only marginally expressed hGSTA1/2, hGSTA4-4 and hGSTM1-1. (elsevier.com)
  • Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells. (nih.gov)
  • Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. (nih.gov)
  • Levels of caspase-9, caspase-10, MAVS, and pIRF7 in mononuclear cells and the disease activity index (SLEDAI) in the systemic lupus erythematosus patients were determined. (nih.gov)
  • caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. (nih.gov)
  • Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. (usc.edu)
  • UPF0488 is a protein that in humans is encoded by the C8orf33 (Chromosome 8 Open Reading Frame 33) gene. (wikipedia.org)
  • A recent epidemiology study has established that each 10 microg/m3 elevation in long-term exposure to average PM2.5 ambient concentration was associated with approximately 8% of lung cancer mortality. (nih.gov)
  • Biallelic or homozygous deletion (HD) of FOXO3 was detected in 8 of 33 (24.2%) mostly early-stage LAC of smokers. (elsevier.com)
  • Chromosome 8 open reading frame 33 (C8orf33) is a human protein-coding gene of currently unknown function. (wikipedia.org)
  • With the present limit of detection (approximately 1 adducted base per 10(8) normal base pairs for 100 micrograms of DNA), the technique is applicable to in vivo samples. (biomedsearch.com)
  • The heavy chain is approximately 45 kDa and its gene contains 8 exons. (usc.edu)
  • Using liquid chromatography coupled with tandem mass spectrometry, this study identified serine 9 of GNMT as the phosphorylation site upon BaP treatment. (elsevier.com)
  • May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. (ucsc.edu)
  • Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. (nih.gov)