Zymomonas: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that is not known to be pathogenic for man, animals, or plants. Its organisms are spoilers for beers and ciders and in sweet English ciders they are the causative agents of a secondary fermentation known as "cider sickness." The species Z. mobilis is used for experiments in molecular genetic studies.Host Factor 1 Protein: An integration host factor that was originally identified as a bacterial protein required for the integration of bacteriophage Q beta (ALLOLEVIVIRUS). Its cellular function may be to regulate mRNA stability and processing in that it binds tightly to poly(A) RNA and interferes with ribosome binding.Pyruvate Decarboxylase: Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 188.8.131.52.3' Untranslated Regions: The sequence at the 3' end of messenger RNA that does not code for product. This region contains transcription and translation regulating sequences.Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.5' Untranslated Regions: The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.XyloseUntranslated Regions: The parts of the messenger RNA sequence that do not code for product, i.e. the 5' UNTRANSLATED REGIONS and 3' UNTRANSLATED REGIONS.Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)TDP-43 Proteinopathies: Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.Protein Biosynthesis: The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.Frontotemporal Lobar Degeneration: Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Proteostasis Deficiencies: Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.Inclusion Bodies: A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)Motor Neurons: Neurons which activate MUSCLE CELLS.RNA-Binding Protein FUS: A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Sinus Arrest, Cardiac: The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is characterized by a prolonged pause without P wave in an ELECTROCARDIOGRAM. Sinus arrest has been associated with sleep apnea (REM SLEEP-RELATED SINUS ARREST).Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Connexins: A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.Gymnotiformes: An order of neotropical electric fish found chiefly in the waters of South America. They continually emit weak electric discharges, which they use in object location and communication. A most popular species of research interest is the electric eel, ELECTROPHORUS electricus.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Electric Fish: Fishes which generate an electric discharge. The voltage of the discharge varies from weak to strong in various groups of fish. The ELECTRIC ORGAN and electroplax are of prime interest in this group. They occur in more than one family.Animal Communication: Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Cementoma: An odontogenic fibroma in which cells have developed into cementoblasts and which consists largely of cementum.Ameloblastoma: An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.Mandibular Neoplasms: Tumors or cancer of the MANDIBLE.Myxoma: A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. It appears also in the jaws and the skin. (From Stedman, 25th ed)Maxillary Neoplasms: Cancer or tumors of the MAXILLA or upper jaw.Fibroma: A benign tumor of fibrous or fully developed connective tissue.Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.Odontogenic Tumors: Neoplasms produced from tooth-forming tissues.Fibroma, Ossifying: A benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
... untranslated region 252 bp long. 3' untranslated region 1,129 bp long. 10 splice isoforms that encode good proteins, altogether ... In this same region of the promoter, there is also a TATA-binding factor sequence, which helps in the positioning of RNA ... The protein is highly conserved in the DUF776 region amongst vertebrates, and also at the C-terminus in eukaryotes. Using tools ... 294 (5): 1351-62. doi:10.1006/jmbi.1999.3310. PMID 10600390. Human OSER1 genome location and OSER1 gene details page in the ...
Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES)
... untranslated region of human hsp70 mRNA". J Biol Chem. 278 (25): 22350-22356. doi:10.1074/jbc.M303213200. PMID 12682055. Page ... It has been shown that the 216 nucleotide long 5' UTR contains internal ribosome entry site activity. Rubtsova, MP; Sizova DV; ... Dmitriev SE; Ivanov DS; Prassolov VS; Shatsky IN (2003). "Distinctive properties of the 5'- ...
Collagen, type VI, alpha 2
... untranslated region generated by an alternate exon". J. Biol. Chem. 267 (9): 6188-96. PMID 1556127. Dawson SJ, White LA (1992 ... 1992). "The exon organization of the triple-helical coding regions of the human alpha 1(VI) and alpha 2(VI) collagen genes is ... 14 (1): 113-5. doi:10.1038/ng0996-113. PMID 8782832. Tillet E, Ruggiero F, Nishiyama A, Stallcup WB (1997). "The membrane- ...
... untranslated region". J. Biol. Chem. 269 (32): 20668-73. PMID 8051167. Imataka H, Mizuno A, Fujii-Kuriyama Y, Hayami M (1994 ... Regions around 10 kb upstream and 1 kb downstream of Klf9 transcription start site contain conserved antioxidant response ... a GC box sequence in the promoter region of the rat P-4501A1 gene". EMBO J. 11 (10): 3663-71. PMC 556826 . PMID 1356762. " ... 117 (1): 91-5. PMID 7775404. Imataka H, Nakayama K, Yasumoto K, Mizuno A, Fujii-Kuriyama Y, Hayami M (1994). "Cell-specific ...
NuoG RNA motif
... untranslated regions of nuoG genes. This gene and the downstream genes probably comprise an operon that encodes various ...
Hsp90 cis-regulatory element
... untranslated region elements essential for preferential heat shock translation". J Biol Chem. 279 (48): 49919-49930. doi: ... The Hsp90 cis regulatory element is an RNA element (RNA thermometer) found in the 5' UTR of the Drosophila hsp90 mRNA. It is ...
... untranslated region". Life Sciences. 69 (20): 2361-70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623. Liou JY, Dutschman GE ... "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1-2): 149-56. doi: ... "Characterization of human UMP-CMP kinase enzymatic activity and 5′ ...
Complement receptor 1
The transmembrane region is encoded by 2 exons and the cytoplasmic domain and the 3'-untranslated regions are coded for by two ... untranslated region are contained in one exon. The large extracellular domain of CR1, which has 25 potential N-glycosylation ... This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of ... The promoter region lacks a distinct TATA box sequence. The gene is expressed principally on erythrocytes, monocytes, ...
... untranslated region is shown. Isoform 1, diagramed below, contains a DUF3338 domain, two low complexity regions and a proline ... The factors that are predicted to bind to the promoter region of isoform 2 differ, and twelve of the top twenty predicted ... A total of 556 single nucleotide polymorphisms (SNPs) have been identified in the gene region of INAVA, 96 of which are ... A diagram of the predicted promoter region, with highlighted transcription factor binding sites, is shown to the right. ...
... untranslated region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however ... 267 (5): 3179-84. PMID 1371113. Policastro PF, Daniels-McQueen S, Carle G, Boime I (1986). "A map of the hCG beta-LH beta gene ... The CGB genes are primarily distinguished by differences in the 5' ...
... untranslated region". Life Sci. 69 (20): 2361-70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623. Liou JY, Dutschman GE, Lam ... 12 (5): 751-64. doi:10.1016/j.str.2004.02.038. PMID 15130468. Murata D, Endo Y, Obata T, et al. (2005). "A crucial role of ... 12 (5): 751-764. doi:10.1016/j.str.2004.02.038. Appleby, Todd C.; Larson, Gary; Cheney, I. Wayne; Walker, Heli; Wu, Jim Z.; ... 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801. Pasti C, Gallois-Montbrun S, Munier-Lehmann H, et al. (2003). "Reaction of ...
MraW RNA motif
... untranslated regions of mraW genes. These mraW genes likely form operons with immediately downstream ftsI genes, and multiple ... mraW RNAs are consistently in the presumed 5' ...
... untranslated region". J. Biol. Chem. 283 (5): 2543-2553. doi:10.1074/jbc.M707781200. PMID 18055463. ATF5 protein, human at the ... Al Sarraj J, Vinson C, Thiel G (2005). "Regulation of asparagine synthetase gene transcription by the basic region leucine ... Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene. First ... 20 (5): 942-948. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110. Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ...
GlmS glucosamine-6-phosphate activated ribozyme
... untranslated regions of glmS genes. The GlmS enzyme catalyzes the production of glucosamine-6-phosphate (GlcN6P), and the glmS ... It was originally identified using bioinformatics in the 5' ...
... untranslated regions of its mRNA". J. Biol. Chem. 280 (9): 8581-8. doi:10.1074/jbc.M410806200. PMID 15611123. Hughes TA, Brady ... The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, ... 74 (5): 1043-50. doi:10.1086/386293. PMC 1181967 . PMID 15042511. Mostowska A, Biedziak B, Jagodzinski PP (2006). "Axis ... Hughes TA, Brady HJ (2005). "Expression of axin2 is regulated by the alternative 5'- ...
... untranslated region of the mnt gene". Oncogene. 20 (7): 893-897. doi:10.1038/sj.onc.1204157. PMID 11314024. Page for Mnt IRES ... N-myc IRES Tobamovirus IRES TrkB IRES Stoneley, M; Spencer JP; Wright SC (2001). "An internal ribosome entry segment in the 5' ...
... untranslated region of the mnt gene". Oncogene. 20 (7): 893-7. doi:10.1038/sj.onc.1204157. PMID 11314024. Dintilhac A, Bernués ... "Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region". Genome ... Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617 ... Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617 ...
Fragile mental retardation 2
... untranslated region which leads to a silencing of the gene. Mutations within the gene may also cause this phenotype. This gene ... untranslated region has 10-35 CCG repeats and more frequently 15-20. Pathogenic expansions have typically over 200 repeats and ... Alternative splicing may occur and involve exons 2, 3, 5, 7 and 21. The normal encoded protein is 1311 codons in length. It is ... The most common mutation giving rise to this syndrome is a triplet expansion of CCG in the 5' ...
Transforming growth factor, beta 3
... untranslated region". Molecular and Cellular Biology. 11 (9): 4306-13. doi:10.1128/mcb.11.9.4306. PMC 361291 . PMID 1875922. ... 328 (5): 1173-83. doi:10.1016/S0022-2836(03)00360-7. PMID 12729750. Hart PJ, Deep S, Taylor AB, Shu Z, Hinck CS, Hinck AP (Mar ... 28 (5): 461-85. doi:10.1016/j.dci.2003.09.007. PMID 15062644. Taya Y, O'Kane S, Ferguson MW (Sep 1999). "Pathogenesis of cleft ... 15 (4): 320-5. doi:10.1097/00004347-199610000-00004. PMID 8886879. Djonov V, Ball RK, Graf S, Mottaz AE, Arnold AM, Flanders K ...
... untranslated region of an mRNA in translation regulation during development". Int. J. Biochem. Cell Biol. 31 (1): 87-106. doi: ... and/or untranslated regions (UTRs), potentially altering gene function. Cis-regulatory elements in the promoter contain ... van der Velden AW, Thomas AA (January 1999). "The role of the 5' ...
... untranslated sequences of eukaryotic mRNAs Five prime untranslated region Three prime untranslated region UTRome Grillo, ... a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs". Nucleic Acids Res. 38 (Suppl_ ...
Frontiers | Identification and Characterization of 5′ Untranslated Regions (5′UTRs) in Zymomonas mobilis as Regulatory...
... untranslated region (5′UTR), have been shown in a variety of organisms to control the expression levels of these mRNAs in ... untranslated region (5'UTR), have been shown in a variety of organisms to control the expression levels of these mRNAs in ... we searched natural cis-regulatory regions in this microorganism using transcriptomic data and bioinformatics analysis. ... we searched natural cis-regulatory regions in this microorganism using transcriptomic data and bioinformatics analysis. ...https://www.frontiersin.org/articles/10.3389/fmicb.2017.02432/full
Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional...
... untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation.. Song KY1, Choi HS, ... untranslated region (UTR) of the mouse MOR was found to be important for post-transcriptional regulation of the MOR gene in ... untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation ... untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation ...https://www.ncbi.nlm.nih.gov/pubmed/23353576
Mutation Analysis of the 5′ Untranslated Region of the Cold Shock cspA mRNA of Escherichia coli | Journal of Bacteriology
Untranslated Region of the Cold Shock cspA mRNA of Escherichia coli Kunitoshi Yamanaka, Masanori Mitta, Masayori Inouye ... Untranslated Region of the Cold Shock cspA mRNA of Escherichia coli Message Subject (Your Name) has forwarded a page to you ... end untranslated region of the mRNA for CspA, the major cold-shock protein of Escherichia coli, in cold-shock adaptation. J. ... untranslated region (5′-UTR), and its stability has been shown to play a major role in cold shock induction of CspA. The 5′-UTR ...https://jb.asm.org/content/181/20/6284
The 5′ untranslated region of the soybean cytosolic glutamine synthetase β1 gene contains prokaryotic translation initiation...
Ortega JL, Moguel-Esponda S, Potenza C, Conklin CF, Quintana A, Sengupta-Gopalan C (2006) The 3′ untranslated region of a ... Simon B, Sengupta-Gopalan C (2010) The 3′ untranslated region of the two cytosolic glutamine synthetase (GS1) genes in alfalfa ... untranslated region in Cap-independent translation of Turnip Crinkle Virus. J Virol 85:4638-4653PubMedCrossRefGoogle Scholar ... untranslated region of the HSP18.2 gene contributes to efficient translation in plant cells. J Biosci Bioeng 95:52-58PubMed ...https://link.springer.com/article/10.1007%2Fs00438-012-0724-6
The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5′Untranslated-Region-Directed Translation Blockers of the...
... untranslated region (5′UTR) in a manner similar to its action to limit the expression of the AD-specific amyloid precursor ... Untranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Sohan Mikkilineni,1 Ippolita ... The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5′ ... blocked neural SNCA mRNA translation and tested for targeting via its 5′ ...https://www.hindawi.com/journals/pd/2012/142372/abs/
A 5'-proximal stem-loop structure of 5' untranslated region of porcine reproductive and respiratory syndrome virus genome is...
... untranslated region of porcine reproductive and respiratory syndrome virus genome is key for virus replication.. Lu J1, Gao F, ... untranslated region (5' UTR) of many positive-stranded RNA viruses contain key cis-acting regulatory sequences, as well as high ... Untranslated Region of Porcine Reproductive and Respiratory Syndrome Virus Genome Is Key for Virus Replication ... Untranslated Region of Porcine Reproductive and Respiratory Syndrome Virus Genome Is Key for Virus Replication ...https://www.ncbi.nlm.nih.gov/pubmed/21496223?dopt=Abstract
A novel nucleotide substitution in the 5′ untranslated region of ANKRD26 gene is associated with inherited thrombocytopenia: a...
... untranslated region (UTR).. Case 1. A 32-year-old woman was evaluated for chronic thrombocytopenia, platelet counts ranging ... untranslated region of ANKRD26 gene is associated with inherited thrombocytopenia: a report of two new families. ... Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation. J Clin Invest 124(2):580- ... 5.. Pippucci T, Savoia A, Perrotta S, Pujol-Moix N, Noris P, Castegnaro G, Pecci A, Gnan C, Punzo F, Marconi C, Gherardi S, ...https://link.springer.com/article/10.1007%2Fs00277-019-03632-y
The 5'-Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element;...
We report the presence of a homology in the 5'untranslated region (UTR) of the messenger RNA encoding C9orf72 with the iron ... Untranslated Region. We propose novel small molecule therapies for ALS and FTD based on the strategy of screening and ... Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel ... Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel ...https://www.scirp.org/Journal/PaperInformation.aspx?PaperID=64785
Inhibition of Corticotropin Releasing Hormone Type-1 Receptor Translation by an Upstream AUG Triplet in the 5′ Untranslated...
untranslated region. ORF. open reading frame. GFP. green fluorescent protein. uORF. upstream open reading frame. CRHR. ... Untranslated Region. Guoheng Xu, Cristina Rabadan-Diehl, Maria Nikodemova, Peter Wynn, Joachim Spiess and Greti Aguilera ... Untranslated Region. Guoheng Xu, Cristina Rabadan-Diehl, Maria Nikodemova, Peter Wynn, Joachim Spiess and Greti Aguilera ... Untranslated Region. Guoheng Xu, Cristina Rabadan-Diehl, Maria Nikodemova, Peter Wynn, Joachim Spiess and Greti Aguilera ...http://molpharm.aspetjournals.org/content/59/3/485
The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5′ untranslated region in a polyamine...
... untranslated region in a polyamine-independent way. H Van Steeg, C T M Van Oostrom, H M Hodemaekers, L Peters, A A M Thomas ... untranslated region in a polyamine-independent way Message Subject (Your Name) has forwarded a page to you from Biochemical ... untranslated region (5′ UTR) of the ODC mRNA of different species is rather unusual in length and GC content, and may therefore ... untranslated region in a polyamine-independent way ... untranslated region in a polyamine-independent way. H Van Steeg ...http://www.biochemj.org/content/274/2/521
Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5′...
... untranslated region of mRNA. William J. TUXWORTH Jr, Atif N. SAGHIR, Laura S. SPRUILL, Donald R. MENICK, Paul J. McDERMOTT ... untranslated region). The activity of eIF4E was modified in primary cultures of adult cardiocytes using adenoviral gene ... The insertion of G+C-rich repeats into the 5´-UTR doubled the predicted amount of secondary structure and was sufficient to ... Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5 ...http://www.biochemj.org/content/378/1/73
Genome-wide functional analysis of human 5' untranslated region introns | Genome Biology | Full Text
... untranslated region (UTR). Introns in 5'UTRs differ from those in coding regions and 3'UTRs with respect to nucleotide ... Hong X, Scofield DG, Lynch M: Intron size, abundance, and distribution within untranslated regions of genes. Mol Biol Evol. ... untranslated regions in carcinogenesis. Biochem Soc Trans. 2008, 36: 708-711. 10.1042/BST0360708.PubMedView ArticleGoogle ... Structural and functional features of eukaryotic mRNA untranslated regions. Gene. 2001, 276: 73-81. 10.1016/S0378-1119(01)00674 ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-3-r29
Effect of single-nucleotide polymorphisms of the 5′ untranslated region of the human α-galactosidase gene on enzyme activity,...
... untranslated region of the human α-galactosidase gene on enzyme activity, and their frequencies in Portuguese caucasians. ... untranslated region of exon 1, respectively g.1150G>A, g.1168G>A, g.1170C>T. The g.1150A allele is associated with increased ... The α-galactosidase gene (GLA) has three single-nucleotide polymorphisms in the 5′ ... Effect of single-nucleotide polymorphisms of the 5′ ...https://insights.ovid.com/jimed/200812002/00005513-200812002-00011
The relationship between the variants in the 5'-untranslated regions of equine chorionic gonadotropin genes and serum equine...
... untranslated regions (5′-UTR) of eCGβ was identified in previous study . The objective of the present study was to ... untranslated regions (5′-UTR) of equine chorionic gonadotropin (eCG) genes and the serum eCG levels. ... untranslated regions of equine chorionic gonadotropin genes and serum equine chorionic gonadotropin levels ... untranslated regions of equine chorionic gonadotropin genes and serum equine chorionic gonadotropin levels. ...https://www.ajas.info/journal/view.php?number=23742
Molecular Analysis of Enterovirus C Species Using the 5' Untranslated Region and VP1 Region | MedCrave
Untranslated Region and VP1 Region Fei Zhou*, Matthew VN O'Sullivan, Jonathan R Iredell, Vitali Sintchenko, Gwendolyn L Gilbert ... untranslated region and VP1 region to examine the molecular diversity in enterovirus B species. J Med Microbiol 63(10): 1339- ... untranslated region (UTR) is fundamentally important for efficient viral replication and for virulence; the VP1 region ... Untranslated Region and VP1 Region. J Hum Virol Retrovirol 2(2): 00038. DOI: 10.15406/jhvrv.2015.02.00038 ...http://googlescholar.medcraveonline.com/scholars/article_fulltext/1026
GSE8888 - A novel tumor-promoting function resided in the 5' untranslated region of vegf mRNA - OmicsDI
... mutated vegf mRNAs lacking untranslated regions (UTRs), and 5'UTR mutated between nt 591 and nt 746, we found that vegf 5'UTR ... In addition to 5-fluorouracil treatment, the vegf 5'UTR-expressing tumors did not respond to IFN alpha therapy at all. This ... The reference RNA of vegf 5' mut-D5-derived tumor was arranged in the same manner. The quality of both RNA samples was ... Microarray analysis was then performed: briefly, 1 µg of sample RNA (vegf 5'-G5) and reference RNA (vegf 5' mut-D5) were ...https://www.omicsdi.org/dataset/geo/GSE8888
The deletion of an extra six nucleotides in the 5′ -untranslated region of the nucleoprotein gene of Newcastle disease virus NA...
... untranslated region (UTR) of the nucleoprotein (NP) gene. This extra sequence, TCCCAC, is highly conserved and has been found ... Following deletion of six nucleotides in the 5′-UTR of the NP gene of NDV strain NA-1, the virulence of the rNA-1(−) ... untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence ... From: The deletion of an extra six nucleotides in the 5′ - ... have an extra six nucleotides in the 5′- ...https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-014-0305-5/figures/3
Arabidopsis thaliana cold-regulated 47 gene 5′-untranslated region enables stable high-level expression of transgenes - PubAg
... untranslated region enables stable high-level expression of transgenes. Author:. Yamasaki, Shotaro, Sanada, Yuji, Imase, Ryoji ... untranslated region (5′UTR) sequences in certain genes which act as translational enhancers. On the other hand, translation in ... untranslated regions, Arabidopsis thaliana, data collection, enhancer elements, environmental factors, gene expression, ... We found the 5′UTR of cold-regulated 47 gene to be an effective translational enhancer, contributing to stable high-level ...https://pubag.nal.usda.gov/catalog/5818855
Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1...
... untranslated regions (UTRs) of mRNAs, the understanding of the significance and the regulation of these variations is rather ... We investigated 5' UTR mRNA variants of the mouse Gli1 oncogene, which is the terminal transcriptional effector of the Hedgehog ... Moreover, the alternative Gli1 5' UTRs had an impact on translational capacity, with the shorter and the exon 1B-skipped mRNA ... The GT allele, which contains the consensus intronic dinucleotides at the 5' splice site of intron 1B, favors exon 1B inclusion ...https://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-2199-11-32
The 5'-Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element;...
Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel ... Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel ... Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel ... Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel ...http://libros.duhnnae.com/2017/jun8/149829012028-The-5-Untranslated-Region-of-the-C9orf72-mRNA-Exhibits-a-Phylogenetic-Alignment-to-the-Cis-Aconitase-Iron-Responsive-Element-Novel-Therapies-for-A.php
- The 5′UTR-mediated translational enhancement is probably another step in the regulation of GS in plants. (springer.com)
- The 5′ untranslated region (5′ UTR) of the ODC mRNA of different species is rather unusual in length and GC content, and may therefore be involved in translational control of ODC protein synthesis. (biochemj.org)
- We tested the hypothesis that increases in eIF4E activity selectively improve the translational efficiency of mRNAs that have an excessive amount of secondary structure in the 5´-UTR (5´-untranslated region). (biochemj.org)
- Subsequently, the effects of eIF4E on translational efficiency were assayed following adenoviral-mediated expression of luciferase reporter mRNAs that were either 'stronger' (less structure in the 5´-UTR) or 'weaker' (more structure in the 5´-UTR) with respect to translational efficiency. (biochemj.org)
- The expression level of transgenes can be increased by 5′-untranslated region (5′UTR) sequences in certain genes which act as translational enhancers. (usda.gov)
- We found the 5′UTR of cold-regulated 47 gene to be an effective translational enhancer, contributing to stable high-level expression under various conditions. (usda.gov)
- They can also influence translation of coding regions by reducing the access of translational machinery to the coding regions. (news-medical.net)
- The α-galactosidase gene (GLA) has three single-nucleotide polymorphisms in the 5′ untranslated region of exon 1, respectively g.1150G>A, g.1168G>A, g.1170C>T. The g.1150A allele is associated with increased plasma α-galactosidase (α-Gal) activity in hemizygotes, while the others are regarded as biologically neutral. (ovid.com)
- An experiment was conducted to study the association between the single nucleotide polymorphisms (SNPs) in 5′-untranslated regions (5′-UTR) of equine chorionic gonadotropin ( eCG ) genes and the serum eCG levels. (ajas.info)
- The GT allele, which contains the consensus intronic dinucleotides at the 5' splice site of intron 1B, favors exon 1B inclusion, while the GC allele, having a weaker 5' splice site sequence, promotes exon 1B skipping. (biomedcentral.com)
- Exon 5 is lacking from osteopontin-b, whereas osteopontin-c lacks exon 4. (wikipedia.org)
- Approximately 35% of human genes contain introns within the 5' untranslated region (UTR). (biomedcentral.com)
- In summary, these differences suggest that introns in different regions of genes constitute distinct functional classes with unique evolutionary histories. (biomedcentral.com)
- SNPs in 5′-UTR of eCG genes were screened across 10 horse breeds, including 7 Chinese indigenous breeds and 3 imported breeds using iPLEX chemistry, and the association between the serum eCG levels of 174 pregnant Da'an mares and their serum eCG levels (determined with ELISA) was analyzed. (ajas.info)
- Although regulatory regions do not code for proteins, they contain promoters and enhancers which can influence the expression of coding genes. (news-medical.net)
- Also, any structural alterations in these regions, such as translocations, deletions, insertions, or duplications can lead to changes in the interaction between the regulatory elements and coding genes. (news-medical.net)
- ii) Predicted RNA secondary structure of the consensus 5'-proximal 246 nt generated by comparison of nine type II PRRSV genomes. (nih.gov)
- iii) Predicted secondary structure of the 5'-proximal 246 nt of mutant EX generated by substituting N-SL2 with E-SL2. (nih.gov)
- From this we conclude that the well-documented negative feedback control of intracellular polyamines on ODC expression is not regulated by effects of polyamines on the secondary structure of the 5′ UTR of ODC mRNA. (biochemj.org)
- 30 predicted Serine phosphorylation sites 5 predicted Threonine phosphorylation sites 3 predicted Tyrosine phosphorylation sites PELE (Protein Secondary Structure Prediction) was used to predict the secondary structure of C20orf111. (wikipedia.org)
- In addition to identifying novel transcription start sites, we demonstrated that the expression ratio of the Gli1 splice variants in the 5' UTR is regulated by the genotype of the mouse strain analyzed. (biomedcentral.com)
- The rest of the genome consists of non-coding RNA, untranslated regions, splice sites and transposable elements. (news-medical.net)
- Introns are also non-coding regions, and often mutations and alterations in introns and intronic splice sites do not receive much attention. (news-medical.net)
- We describe two IT cases presenting during pregnancy, one of whom harbored a novel, pathogenic nucleotide substitution in ANKRD26 gene 5′ untranslated region (UTR). (springer.com)
- Introns in 5'UTRs differ from those in coding regions and 3'UTRs with respect to nucleotide composition, length distribution and density. (biomedcentral.com)
- The 5' UTR is relatively conserved at the nucleotide level, and is often used for nucleic acid testing to diagnose EV infections [5, (medcraveonline.com)
- While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered that in vivo expression of dsRNA of the α-tubulin mRNA 5′ untranslated region (5′ UTR) led to multinucleated cells with striking morphological alterations and a specific block of cytokinesis. (pnas.org)
- Transfection of synthetic α-tubulin 5′ UTR dsRNA, but not of either strand individually, caused the same phenotype. (pnas.org)
- For each transfection, 10 8 procyclic T. brucei rhodesiense cells, strain Ytat1.1, were washed four times in Cytomix (120 mM KCl/0.15 mM CaCl 2 /10 mM K 2 HPO 4 /25 mM Hepes (pH 7.6)/2 mM EDTA/5 mM MgCl 2 ) and resuspended in 0.5 ml of Cytomix. (pnas.org)
- It was found that none of the deletion mutations had significant effects on the stability of mRNA at both 37 and 15°C. However, two mutations (Δ56-86 and Δ86-117) caused a substantial increase of β-galactosidase activity at 37°C, indicating that the deleted regions contain a negative cis element(s) for translation. (asm.org)
- Mutations in this region can also lead to creation of initiation codons. (news-medical.net)
- For example, generation of premature start codons by mutations in 5'-UTR have been shown to create melanoma. (news-medical.net)
- The influence of an upstream open reading frame (ORF) in the 5′-untranslated region (UTR) of the mRNA on corticotropin-releasing hormone receptor type 1 (CRHR1) translation was studied in constructs containing the 5′-UTR of CRHR1, with or without an ATG-to-ATA mutation in the upstream ORF, and the main ORF of luciferase or CRHR1. (aspetjournals.org)
- Upstream mutation in luciferase constructs increased luciferase activity when transfected into COS-7 or AtT20 cells compared with the native 5′-UTR. (aspetjournals.org)
- Pertinent to this, we identified that the well-tolerated anticholinesterase, phenserine, blocked neural SNCA mRNA translation and tested for targeting via its 5 ′ untranslated region (5 ′ UTR) in a manner similar to its action to limit the expression of the AD-specific amyloid precursor protein (APP). (hindawi.com)
- The study shows that the upstream AUG in 5′-UTR of CRHR1 mRNA inhibits receptor expression by inhibiting mRNA translation and suggests the short open reading frame in the 5′-UTR plays a role in regulating translation of the CRH receptor. (aspetjournals.org)
- A 5'-proximal stem-loop structure of 5' untranslated region of porcine reproductive and respiratory syndrome virus genome is key for virus replicat. (nih.gov)
- Stem-loop structures are designated as E-SL1-5 for type I PRRSV and N-SL1-5 for type II, respectively. (nih.gov)
- In the 5' UTR, the cloverleaf structure of domain (stem-loop) I is important for viral replication [2,while domains II to VI encompass the internal ribosome entry site (IRES) which directs translation of the mRNA by internal ribosome binding . (medcraveonline.com)
- Gallie DR (2002) The 5′-leader of tobacco mosaic virus promotes translation through enhanced recruitment of eIF4F. (springer.com)
- It stimulates the growth of the dominant follicle [ 5 , 6 ] and promotes the increase of circulating progesterone concentrations in the subsequently estrus cycle [ 6 , 7 ]. (ajas.info)
- Translation of the mouse MOR gene is controlled by 5′UTR-deletion analysis. (nih.gov)
- Considering the unique tolerance of Zymomonas mobilis to ethanol and the growing interest in engineering microbial strains with enhanced tolerance to industrial inhibitors, we searched natural cis -regulatory regions in this microorganism using transcriptomic data and bioinformatics analysis. (frontiersin.org)
- After removing contaminated DNA by DNaseI treatment, 10 micro grams each of RNA of vegf 5'-G5-derived tumor from 3 individual mice was mixed and prepared for microarray analysis as sample RNA. (omicsdi.org)
- Microarray analysis was then performed: briefly, 1 µg of sample RNA (vegf 5'-G5) and reference RNA (vegf 5' mut-D5) were converted to cDNA with oligo dT conjugated T7 promoter primer and reverse transcriptase. (omicsdi.org)
- Northern blot analysis indicated that the enhanced expression of 5′,3′-UTR-deleted gEpo might be related with the transcription efficiency. (kribb.re.kr)
- The short open reading frame (ORF) present in the 5′ UTR of rat ODC mRNA does not contribute to the observed inhibitory effect on translation efficiency in vitro . (biochemj.org)
- At low polyamine concentration the efficiency of translation in vitro of intact ODC mRNA is not relatively increased compared with that of an ODC mRNA having a truncated 5′ UTR or with that of control globin mRNA. (biochemj.org)
- Agalarov SC, Sogorin EA, Shirokikh NE, Spirin AS (2011) Insight into the structural organization of the omega leader of TMV RNA: the role of various regions of the sequence in the formation of a compact structure of the omega RNA. (springer.com)
- and 4) when extensive base-pairs in the stem region was deleted, an alternative N-SL2-like structure with different sequence was utilized for virus replication. (nih.gov)
- In this same region of the promoter, there is also a TATA-binding factor sequence, which helps in the positioning of RNA polymerase II for transcription. (wikipedia.org)
- Previously, the 5'-untranslated region (UTR) of the mouse MOR was found to be important for post-transcriptional regulation of the MOR gene in neuronal cells. (nih.gov)
- To identify potential regulators of the mouse MOR gene, we performed affinity column chromatography using 5'-UTR-specific RNA oligonucleotides using neuroblastoma NS20Y cells. (nih.gov)
- Dansako T, Kato K, Satoh J, Sekine M, Yoshida K, Shinmyo A (2003) 5′untranslated region of the HSP18.2 gene contributes to efficient translation in plant cells. (springer.com)
- The effect of the 5′-and 3′-untranslated regions (UTR) of human erythropoietin gene (gEpo) on its expression in mammalian cells was investigated. (kribb.re.kr)
- 5′-UTR-deleted, 3′-UTR-deleted, and 5′,3′-UTR-deleted gEpos were transfected into COS-7 cells, and the amount of transiently expressed Epo was measured. (kribb.re.kr)
- Cells transfected with the 5′,3′-UTR-deleted gEpo showed the highest expression, 2.6 times that with wild-type gEpo. (kribb.re.kr)
- Ligands on the surface of parasitized red cells can bind to a number of endothelial cell receptors, including CD36 ( 1 ), intercellular adhesion molecule-1 ( 2 ), thrombospondin ( 3 ), chondroitin-4-sulfate ( 4 ), vascular cell adhesion molecule-1 ( 5 ), E selectin ( 5 ), and platelet/endothelial cell adhesion molecule-1 ( 6 ). (pnas.org)
- Furthermore, it was shown that the 14-base downstream box located 12 bases downstream of the translation initiation codon of the cspA mRNA, which is partially complementary to a region, called anti-downstream box, of 16S rRNA ( 30 ), plays an important role in efficient translation at low temperature ( 6 , 21 ). (asm.org)
- The presence of the GS 1 5′UTR in front of the GS 1 coding region allowed for its translation in E. coli suggesting the commonality of the translation initiation mechanism for this gene between plants and bacteria. (springer.com)
- Our data suggest that vimentin functions as a repressor of MOR translation, dependent on 175-150 of the MOR 5'-UTR. (nih.gov)
- Our results show that the intact 5′ UTR of rat ODC mRNA, which is 303 nt in length, is a potent inhibitor of translation. (biochemj.org)
- They can bind to complimentary regions on mRNA and prevent their translation and reduce the stability. (news-medical.net)