Alpha-fetoprotein

ABCC3

DNA polymerase beta

Placental alkaline phosphatase

PLA2G4A

IRF2

PTK6

ADAMTS4

Factor XII

Beta-glucuronidase

PAX7

Anne M. Andrews

Endothelin A receptor

RGS3

Estrogen receptor alpha

Polymeric immunoglobulin receptor

Glycoside hydrolase family 59

RRM1

Phosducin

ACTR1A

Corticotropin-releasing hormone

Galactosylceramidase

Follicle-stimulating hormone receptor

TOP3A

CYP3A5

Gastric inhibitory polypeptide receptor

TGF alpha

Pyruvate dehydrogenase (lipoamide) beta

Transcortin

PPP1R12A

Battle of Poitiers

Tikal

Sumer

Protein-protein interaction

Retreat of glaciers since 1850

Berbers

Scleractinia

Paul von Hindenburg

Safavid Iran

Lübeck

Hagfish

Fault (geology)

Hindu temple

Makara

Cheonan

Transcription factor

Camel

Mount Pinatubo

Self-anointing in animals

Tysons, Virginia

Pontius Pilate

Clark Atlanta University

Victor Emmanuel II Monument

Italian War of 1521-1526

Tynemouth

Çatalhöyük

Undulated tinamou

Desert

Newport, Rhode Island

Mountain tapir

Nucleotide7

• Abbreviations used: nt = nucleotide, nts = nucleotides, UTR = untranslated region of the mRNA. (hgvs.org)
• Analysis of the aroB nucleotide sequence and its 5' and 3' flanking regions has identified the aroB promoter and possible 3' terminator sequences. (bl.uk)
• n = 15) rice populations, no segregating site was observed in six miRNA binding sites whereas 0.12-0.20 SNPs per 21-nt or 1.53-1.80 × 10 -3 of the average pairwise nucleotide diversity (π) were found in their flanking regions. (biomedcentral.com)
• 1%. This study confirmed that nucleotide substitutions of this region are transition mutations in outbreak cases, that insertion was observed only in non-severe cases, and that these nucleotide substitutions were different from those of the sporadic case. (medsci.org)
• The sensitivity of Sanger sequencing is over 99% for the detection of nucleotide base changes, small deletions and insertions in the regions analyzed. (cincinnatichildrens.org)
• The GTP is placed "backward" on the 5′ end of the mRNA, so that the 5′ carbons of the GTP and the terminal nucleotide are linked through three phosphates. (lumenlearning.com)
• Recent studies showed that a polymorphism (T to C nucleotide substitution) in the 3′ flanking region of the human CLOCK gene is associated with diurnal preferences of human healthy subjects, with higher " eveningness" in subjects carrying at least one copy of the C allele. (elsevier.com)

Exons7

• Here we show that the rat BDNF gene consists of four short 5′ exons and one 3′ exon encoding the mature BDNF protein. (cell.com)
• Several transcription initiation sites were mapped upstream of the four 5′ exons, and transfection of promoter-reporter gene constructs confirmed that these sequences act as promoters. (cell.com)
• The regions of RNA that code for protein are called exons (Figure 1). (lumenlearning.com)
• Exons 3 through 14 are contained in a genomic region of only 4.2 kbp with introns ranging in size from 80 to 554 bp. (ubc.ca)
• The multiple regions found in the coding sequence of FXII that are homologous to putative domains in fibronectin and tissue-type plasminogen activator are contained on separate exons in the factor XII gene. (ubc.ca)
• The NKX2-5 gene on chromosome 5q34 consists of two exons which encode a 324 amino acid protein. (cdc.gov)
• The coding region contained five exons encoding 376 aminoacids and four introns ranging in size from 109 - 190bp. (who.int)

Sequences11

• The 5′ and 3′ end primers were designed to contain 16-17 nucleotides homologous to the template sequence, with restriction enzyme sites and flanking nucleotides upstream of the homologous sequences. (elsevier.com)
• The 5′ end oligonucleotide contained 18 nucleotides corresponding to sequences upstream of the putative suppressor element and another 18 nucleotides corresponding to sequences downstream of the putative suppressor element. (elsevier.com)
• The 5' flanking region of the ornithine transcarbamylase gene contains DNA sequences regulating tissue-specific expression. (wikidata.org)
• Several consensus sequences, including four Sp1 binding sites, were found in the 5' flanking region of this gene. (elsevier.com)
• In contrast to mutations in coding regions affecting peptide sequences and possibly modifying protein structure and function, the consequences of intronic sequences are not predictable. (biomedcentral.com)
• The amino acid sequence contains a region with some homology to sequences found in other kinases and ATP-requiring enzymes. (bl.uk)
• Analysis of the 3' flanking sequences has identified possible terminator elements. (bl.uk)
• The immediate 5'-flanking region is dominated by a dense cluster of Alu repeats in which are embedded several promoter consensus sequences. (elsevier.com)
• Analysis of the 5' flanking region of the gene shows that it does not contain the typical TATA and CAAT sequences found in other genes. (ubc.ca)
• The region of DNA which borders the 5' end of a transcription unit and where a variety of regulatory sequences are located. (bvsalud.org)
• The swquences around the 5' and 3' splice sites were fairly conserved when compared to the eukaryotic consensus sequences and those of parasitic nematodes. (who.int)

Sequence10

• DNA sequence analysis revealed that there are several kappaB-like sites within the 5'-flanking region of the bcl-x gene. (cdc.gov)
• Sequence substitution analysis indicated that the synonymous substitution rate was significantly lower in the miRNA binding sites than their 5' and 3' flanking regions. (biomedcentral.com)
• Deletion analysis of the 1,058 bp of rat FGF-2 5'-flanking DNA showed that an increase in FGF-2 transcription using phenylephrine (PE, an _1-specific agonist) for 48 h could be elicited with only 313 bp of upstream sequence. (umanitoba.ca)
• These oligonucleotides encoded regions of β-factor Xlla as predicted from the amino acid sequence. (ubc.ca)
• DNA sequence analysis of these overlapping clones showed that they contained DNA coding for the signal peptide sequence, the complete amino acid sequence of plasma factor XII, a TGA stop codon, a 3' untranslated region of 150 nucleotides, and a poly A⁺ tail. (ubc.ca)
• Comparison of the structure of factor XII with other proteins revealed extensive sequence identity with regions of tissue-type plasminogen activator (the epidermal growth factor-like region and the kringle region) and fibronectin (type I and type II homologies). (ubc.ca)
• The carboxyl-terminal region of factor XII shares considerable amino acid sequence homology with other serine proteases including trypsin and many clotting factors. (ubc.ca)
• 10 13 These sequence variants were primarily identified within malformed regions and not in unaffected regions taken from the same heart, indicating a somatic and mosaic nature for these variants. (cdc.gov)
• At the 5' flanking region, a putative mRNA initiation site and a potential `TATA' box with the sequence TATAAA could be identified, though a sequence similar to the ` CAAT ` box could not be identified. (who.int)
• At the 3' flanking region, a potential polyadenylation signal with the sequence ATTAAA could be identified. (who.int)

Mutations6

• During the analysis of the 5′ flanking region of the androgen receptor, we have used the PCR technique extensively to create mutations. (elsevier.com)
• Analysis of UDPSs detected low-prevalence HAV variations in 5 ' UTR, but no specific mutations associated with severity in these outbreak cases. (medsci.org)
• Mutations in regulatory regions or other untranslated regions are not detected by this test. (cincinnatichildrens.org)
• Heterozygous deletions, insertions, genetic recombination events, as well as mutations in regulatory regions or other untranslated regions are not detected by this test. (cincinnatichildrens.org)
• Somatic mutations in NKX2-5 do not represent an important aetiologic pathway in pathologic cardiac development in patients with cardiac septal defects. (cdc.gov)
• Somatic mutations were identified in NXK2-5 and its molecular partners, TBX5 and GATA4 , as well as the transcription factor HEY2 in formalin fixed tissue taken from a collection of hearts with atrial septal defects (ASD), 8 ventricular septal defects (VSD), and atrioventricular canal defects (AVCD). (cdc.gov)

Exon1

• however, no homology was found in the exon 1 and intron 1 region. (elsevier.com)

MRNA1

• The 5′ cap , which is placed on the 5′ end of the mRNA, is usually composed of a methylated guanosine triphosphate molecule (GTP). (lumenlearning.com)

Protein4

• The specificity of RGS4 protein for the G iα and G qα subfamilies likely relies on the structure of the switch regions. (aspetjournals.org)
• The A/G-rich region does carry enhancer activity and does bind nuclear protein with high affinity and specificity. (umanitoba.ca)
• FUS3 protein physically interact with two RY elements present in the AtGA3ox promoter;RY repeats are conserved in the 5 prime-flanking region of legume seed protein genes. (ugent.be)
• Reverse transcriptase-polymerase chain reaction (RT-PCR) assay of the stop codon region of the outer membrane protein A ( ompA ) gene of Rickettsia felis using primer set 3 (nucleotides 1836-2180). (ajtmh.org)

Genetics1

• Annals of human genetics 2010 Sep 74 (5): 387-98. (cdc.gov)

CAAT1

• The 5' flanking region of ACL had the CAAT box on -92 bp from the transcription initiation site (+ 1), however, the TATA box was not found. (elsevier.com)

Intronic1

• The cDNA and the entire 10 kb gene have been sequenced including the 5′ regulatory, 3′ regulatory, and intronic regions. (hindawi.com)

Genes5

• PI-2 is a 7-kb region located between the genes that in PI-2-containing isolates and the fi nding that isolates of encode peptidase T (PepT) and ferrochelatase (HemH) ( 9 ). (cdc.gov)
• all identifi ed serotypes expressed highly conserved PI-2 pili The region is composed of 5 genes, which encode 2 sur- supports their potential as a vaccine candidate. (cdc.gov)
• Demethylated regions in neonatal and adult cardiomyocytes are localized in cell type-specific enhancer regions and in gene bodies of cardiomyocyte genes. (nature.com)
• In addition to these four well-conserved "core PKS genes", the neighboring regions encode additional genes, some of which are highly syntenic and conserved between genomes ( Figure 1 ). (cdc.gov)
• The loss of other genes in the deleted region may also influence the signs and symptoms that can occur in 17q12 deletion syndrome. (medlineplus.gov)

Homologous region2

• As the type II region of fibronectin contains a collagen-binding site, the homologous region in factor XII may be responsible for the binding of factor XII to collagen. (ubc.ca)
• The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively. (or.jp)

20231

• 65(1): 4-5, 2023 Jan. (bvsalud.org)

Assay2

• Study reports cloning a 2.6-kb fragment of the 5' flanking region of the PCAN1 gene which represented promoter activity and was regulated by NKX3.1, p53, Sp1, Pten and 9-cis-RA in the luciferase reporter assay. (nih.gov)
• 5 We used data of all cases that were confirmed at the National Reference Laboratory of NCZD by enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA) and polymerase chain reaction (PCR). (who.int)

3'UTR1

• The genome codes a large open reading frame (ORF), which is flanked by 5'-untranslated region (5'UTR) and 3'UTR. (medsci.org)

Putative1

• The putative promoter region is also far different from that reported for GDN/PN-1. (elsevier.com)

Transcription1

• Analysis of the 5-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. (atlasgeneticsoncology.org)

Oligonucleotide1

• Microscopic examination of the specimen from the anal ulcer was positive for acid-fast bacilli and Mycobacterium tuberculosis was confirmed at the time by polymerase chain reaction to amplify polymorphic DNA regions flanking IS6110 by PCR with oligonucleotide primers to the end of IS6110. (who.int)

Neurons1

• In the human brain, the first 5-HT-releasing neurons are present from the fifth week and their numbers increase markedly by the tenth week of gestation 6 . (bvsalud.org)

20202

• Thursday, 20 August - Friday, 21 August 2020 , 8:00 a.m.-5:00 p.m. (aapg.org)
• The armies of India and China are locked in a bitter standoff in the mountainous Ladakh region since 2020. (kdvr.com)

TATA1

• The rat FGF-2 promoter has no TATA box and instead contains G/C-rich regions typical of a housekeeping gene. (umanitoba.ca)

Polyadenylation1

• Eight different BDNF mRNAs with four different 5′ ends and two alternative polyadenylation sites are transcribed from this gene. (cell.com)

Chromosome2

• It is the same region of chromosome 17 that is abnormally copied (duplicated) in people with a 17q12 duplication (described below). (medlineplus.gov)
• It is the same region of chromosome 17 that is deleted in people with 17q12 deletion syndrome (described above). (medlineplus.gov)

Intron1

• NCU-G1 "knockout" musen ble skapt ved innsetting av en "gene-trap" i første intron som fører til stopp i transkripsjonen etter første ekson. (uio.no)

Polymorphic2

• A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. (elsevier.com)
• This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 base pairs), and class 3 (2500 base pairs). (elsevier.com)

Deletion3

• The promoter activity was assayed by transfecting the 3' or 5' deletion clones of ACL- chloramphenicol acetyl transferase (CAT) plasmid into PLC/PRF5 cells. (elsevier.com)
• This deletion excluded an A/G-rich region containing a tandem repeat of an 8 bp element (5'-AGGGAGGG-3 ') which is similar to a phenylephrine-responsive element in the rat ANF promoter. (umanitoba.ca)
• Signs and symptoms of 17q12 deletion syndrome can include abnormalities of the kidneys and urinary system, a form of diabetes called maturity-onset diabetes of the young type 5 (MODY5), delayed development, intellectual disability, and behavioral or psychiatric disorders. (medlineplus.gov)

Epigastric1

• Physical examination revealed a moderate tenderness in the epigastric and right upper quadrant region. (who.int)

Basins3

• Explore the Andes from the comfort of your desk with content from the Andean Basins Virtual Research Symposium organized by AAPG's Latin America and Caribbean Region with support from the Argentine Association of Petroleum Geologists and Geophysicists, the Argentine Geological Society, the Colombian Association of Petroleum Geologists and Geophysicists, the Colombian Geological Society and the Geological Society of Peru. (aapg.org)
• The bedrock of the other network parks consists of sedimentary deposits shed from uplifted mountains into intermountain basins or along the flanks of the mountain ranges. (nps.gov)
• The Denver-Cheyenne and North Park sedimentary basins flank Rocky Mountain National Park and contain vast sediments shed from uplifted rock associated with the Laramide orogeny. (nps.gov)

Amino3

• The amino-terminal portion of E1A decreases transactivation of the NOS2 5′-flanking region, limiting the DNA binding activity of NF-κB and inhibiting NOS2 expression. (elsevier.com)
• These regions undergo the greatest conformational change during GTP hydrolysis, and specific amino acids in RGS4 appear to stabilize them in a transition state facilitating the hydrolysis reaction. (aspetjournals.org)
• The 5-HT neurotransmitter regulates important pathways of mammalian metabolism and is synthesized from the phenylalanine, tyrosine and tryptophan amino acids 5 . (bvsalud.org)

Involvement2

• Involvement of 5'-flanking kB-like sites within bcl-x gene in silica-induced bcl-x expression. (cdc.gov)
• Involvement of the perianal region in tuberculosis is a rare extrapulmonary form of this disease. (who.int)

Septal1

• Our cohort included patients with atrial septal defects (ASD, n = 13), ventricular septal defects (VSD, n = 5), and atrioventricular canal defects (AVCD, n = 10). (cdc.gov)

Amplify1

• Amplify the targeted genomic region with PCR. (idtdna.com)

19971

• However, most herds range from 5 to 15 individuals (Sowls, 1997) and, in the Brazilian Pantanal, the herds usually range from 5 to 10 individuals (Desbiez et al. (bvsalud.org)

Tumour2

• In the present study we have used a new strategy, involving molecular analysis of a DNA site hypermethylated in tumour DNA, to identify a candidate gene in this region (17p13.3). (elsevier.com)
• Multiple characteristics of this gene, including the presence of a p53 binding site in the 5' flanking region, activation of the gene by expression of a wild-type pS3 gene and suppression of G418 selectability of cultured brain, breast and colon cancer cells following insertion of the gene, make HIC-1 gene a strong candidate for a tumour suppressor gene in region 17pl3.3. (elsevier.com)

Methylation1

• Removal of DNA methylation involves oxidation of 5-methyl-cytosine. (nature.com)

Structural2

• In order to mature this area, we have integrated around 150 km of 2D seismic data, 3 wells, and outcropping sections to provide an improved structural interpretation and stratigraphic of the flank within an assigned area. (aapg.org)
• 2 - 4 Because of its critical role in cardiogenesis, NKX2-5 has been a prime candidate in studies to identify the genetic basis of structural congenital heart defects. (cdc.gov)

Diabetes3

• Diabetes , 34 (5), 433-439. (elsevier.com)
• Diabetes 2007 May 56 (5): 1460-7. (cdc.gov)
• [ 5 ] In 2014, the ADA released a position statement on the diagnosis and management of type 1 diabetes in all age groups. (medscape.com)

Genome3

• Whereas most regions of the genome are depleted for CpGs, they are clustered in CpG islands. (nature.com)
• [18] The genome has the usual 5′ methylated cap and a 3′ polyadenylated tail . (wikizero.com)
• The 5' methylated cap and 3' polyadenylated tail allows the positive-sense RNA genome to be directly translated by the host cell's ribosome on viral entry . (wikizero.com)

Conclusion1

• In conclusion, these studies demonstrated that 1,058 bp of rat FGF-2 5' flanking DNA was sufficient to invoke a positive response in cardiac myocytes to catecholamine stimulation specifically through _1-adrenergic receptors, and that this response occurred ' in vitro,' independently of myocyte contraction and Ca2+ influx, as well as 'in vivo' in the adult heart. (umanitoba.ca)

Found3

• He was found to be HIV positive 5 months before admission. (who.int)
• Schweinsburg and Sowls (1972) found that the most severe injuries of the fighting collared peccaries were caused by reciprocal biting of flanks and hindquarters. (bvsalud.org)
• 136] found a clear curvilinear relationship between 5-HT 2A receptor occupancy and plasma QTP concentrations, but only a weak relationship between plasma QTP concentrations and D 2 receptor occupancy. (researchgate.net)

Consists1

• The Rocky Mountain Inventory and Monitoring Network consists of six parks located within the central and northern Rocky Mountain region of the United States in the states of Colorado and Montana. (nps.gov)

Human1

• Two phage clones, λhgACL21 and λhgACL28, harboring the 5' flanking region of human ATP-citrate lyase (ACL) gene were identified by screening about 1.5 X 10 6 recombinant plaques from the λEMBL3-human placental genomic DNA library. (elsevier.com)

Activation1

• Neuroendocrine mechanisms, particularly those related to 5-HT, are associated with the differentiation and activation of osteoblasts and osteoclasts. (bvsalud.org)

Sides2

• As the two sides are constrained into one region as opposed to being spread out into little pockets of activity. (install-game.com)
• A beaver, over the inscription "CANADA", is surrounded with the facial value, flanked on both sides by a maple leaf. (obscurefinds.com)

Oxygen3

• Immunohistochemical analysis of tumor lesions indicated that IL-8 overexpression was predominant in the regions surrounding necrotic areas, where cells were exposed to low oxygen tension (hypoxia) and acidic pH. (aacrjournals.org)
• they were then removed from the water and allowed to freely absorb oxygen for 5 min. (bvsalud.org)
• Interdecadal-decadal climate variability from multicoral oxygen isotope records in the South Pacific Convergence Zone region since 1650 A.D. (columbia.edu)

Species1

• a new species of cichlid fish from the Río de La Plata region in Argentina, Brazil, and Uruguay. (mnhn.fr)

Days2

• Subsequently, the offspring of these animals was subdivided into subgroups according to age of tooth germ development to be studied: 1 and 5 days of life. (bvsalud.org)
• This is the second shootout with police in 5 days, last week another man was killed, 26 year old Eli Morillo. (wordpress.com)

Proteins1

• PI3K proteins modifies specific phosphatidylinositides in phosphorylate phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol-3,4,5-trisphosphate (PIP3). (mingsheng88.org)

Clinical3

• 1999, PI-2-containing isolates were of the same serotypes kb genetic region present in 21%-27% of clinical isolates, but accounted for only 3.6% of all invasive isolates. (cdc.gov)
• HAV IRES derived from clinical isolates have shown various activities in in vitro cell culture [ 5 , 12 ]. (medsci.org)
• Clinical Gastroenterology 24(5): 541-53. (cincinnatichildrens.org)