Hydroxysteroid Dehydrogenases: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Granulosa Cells: Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).Luteinization: Formation of CORPUS LUTEUM. This process includes capillary invasion of the ruptured OVARIAN FOLLICLE, hypertrophy of the GRANULOSA CELLS and the THECA CELLS, and the production of PROGESTERONE. Luteinization is regulated by LUTEINIZING HORMONE.20-Hydroxysteroid Dehydrogenases: A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53).17-Hydroxysteroid Dehydrogenases: A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.Corpus Luteum: The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.11-beta-Hydroxysteroid Dehydrogenase Type 2: An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.3-alpha-Hydroxysteroid Dehydrogenase (B-Specific): A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.11-beta-Hydroxysteroid Dehydrogenase Type 1: A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)Epithelial Sodium Channels: Sodium channels found on salt-reabsorbing EPITHELIAL CELLS that line the distal NEPHRON; the distal COLON; SALIVARY DUCTS; SWEAT GLANDS; and the LUNG. They are AMILORIDE-sensitive and play a critical role in the control of sodium balance, BLOOD VOLUME, and BLOOD PRESSURE.Sodium Channels: Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Diuretics: Agents that promote the excretion of urine through their effects on kidney function.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Sodium Channel Blockers: A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.Epithelial Sodium Channel Agonists: Compounds that either stimulate the opening or prevent closure of EPITHELIAL SODIUM ION CHANNELS.V-Set Domain-Containing T-Cell Activation Inhibitor 1: A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.Partial Pressure: The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cation Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.Iron-Binding Proteins: Proteins that specifically bind to IRON.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Multidrug Resistance-Associated Proteins: A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Repetitive Sequences, Nucleic Acid: Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).Buffaloes: Ruminants of the family Bovidae consisting of Bubalus arnee and Syncerus caffer. This concept is differentiated from BISON, which refers to Bison bison and Bison bonasus.Insulin-Like Growth Factor I: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.Insulin-Like Growth Factor II: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.Insulin-Like Growth Factor Binding Proteins: A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)Insulin-Like Growth Factor Binding Protein 3: One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.Receptor, IGF Type 1: A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Somatomedins: Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.IranInsulin-Like Growth Factor Binding Protein 2: One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.Tephritidae: A large family of fruit flies in the order DIPTERA, comprising over 4,500 species in about 100 genera. They have patterned wings and brightly colored bodies and are found predominantly in the tropical latitudes.ChitinaseCeratitis capitata: A species of fruit fly originating in sub-Saharan Africa but widely distributed worldwide. One of the most destructive fruit pests, its larvae feed and develop on many different fruits and some vegetables.Chitin: A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.Ecdysterone: A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.Pupa: An inactive stage between the larval and adult stages in the life cycle of insects.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Insect Control: The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.False Positive Reactions: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Gene Frequency: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Virus Integration: Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Dependovirus: A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Human Genome Project: A coordinated effort of researchers to map (CHROMOSOME MAPPING) and sequence (SEQUENCE ANALYSIS, DNA) the human GENOME.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.Calcium-Binding Proteins: Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
*  Nav1.2
... flanking region for human brain sodium channel subtype II alpha-subunit". J. Mol. Neurosci. 11 (3): 179-82. doi:10.1385/JMN:11: ... Schade SD, Brown GB (2001). "Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A)". Brain ... 5 (2): 204-8. doi:10.1016/0888-7543(89)90047-5. PMID 2571571. Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and ... doi:10.1016/S0169-328X(00)00145-5. PMID 11000491. Kasai N, Fukushima K, Ueki Y, et al. (2001). "Genomic structures of SCN2A and ...
*  Epithelial sodium channel
... with flanking C-terminal amphipathic TM regions, postulated to contribute to the formation of the hydrophilic pores of the ... They are made of an intracellular N-terminus region followed by a transmembrane domain, a large extracellular loop, a second ... 10 (5): 487-93. doi:10.1038/nm1028. PMID 15077107. Grubb, B. R.; O'Neal, W. K.; Ostrowski, L. E.; Kreda, S. M.; Button, B.; ...
*  5' flanking region
Flanking SNPs are Single nucleotide polymorphisms (SNP) that appear in the flanking region. Polymorphisms in this region can ... flanking region is a region of DNA that is adjacent to the 5' end of the gene. The 5' flanking region contains the promoter, ... flanking region of eukaryotic genomes. A specific transcription factor called CAAT-binding protein binds to this region and ... untranslated region, this region is neither transcribed into RNA, nor translated into a functional protein. These regions ...
*  Alpha-fetoprotein
... flanking region". J. Biol. Chem. 260 (8): 5055-60. PMID 2580830. Ruoslahti E, Pihko H, Vaheri A, et al. (1975). "Alpha ... 7 (5): 267-9. doi:10.1055/s-2008-1071168. PMID 9402482. Lee PI, Chang MH, Chen DS, Lee CY (January 1989). "Serum alpha- ... 26 (5): 1332-43. doi:10.1021/bi00379a020. PMID 2436661. Sakai M, Morinaga T, Urano Y, et al. (1985). "The human alpha- ... The normal range of AFP for adults and children is variously reported as under 50, under 10, and under 5 ng/mL. At birth, ...
*  ABCC3
... flanking region of human MRP3". Biochem. Biophys. Res. Commun. 270 (3): 728-32. doi:10.1006/bbrc.2000.2507. PMID 10772892. Nies ... flanking region, genomic organization and alternative splice variants". Biochim. Biophys. Acta. 1415 (2): 369-74. doi:10.1016/ ... 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752 . PMID 14759258. Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein ... 290 (5): 1427-33. doi:10.1006/bbrc.2002.6367. PMID 11820781. Scheffer GL, Kool M, de Haas M, de Vree JM, Pijnenborg AC, Bosman ...
*  DNA polymerase beta
... flanking region and active promoter". The Journal of Biological Chemistry. 263 (32): 16992-8. PMID 3182828. Abbotts J, SenGupta ... "Two regions in human DNA polymerase beta mRNA suppress translation in Escherichia coli". Nucleic Acids Research. 20 (18): 4859- ... 93 (5): 507-12. doi:10.1007/bf00202813. PMID 8168825. Chyan YJ, Strauss PR, Wood TG, Wilson SH (Aug 1996). "Identification of ... "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149-56. doi: ...
*  Placental alkaline phosphatase
... flanking region by deletion/substitution". J. Biol. Chem. 263 (24): 12020-7. PMID 3042787. Micanovic R, Bailey CA, Brink L, ... untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common ... "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1". Genomics. 73 (1): 50-5. doi: ... 261 (7): 3112-5. PMID 3512548. Ezra E, Blacher R, Udenfriend S (1984). "Purification and partial sequencing of human placental ...
*  PLA2G4A
... flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene". ... flanking region surrounding a human cytosolic phospholipase A2 gene". Biochemical and Biophysical Research Communications. 205 ... 19 (4-5): 683-688. PMID 9745929. Hirabayashi T, Murayama T, Shimizu T (2005). "Regulatory mechanism and physiological role of ... 58 (5-6): 328-333. doi:10.1080/15216540600702289. PMID 16754327. Sharp JD, White DL, Chiou XG, et al. (1991). "Molecular ...
*  IRF2
... flanking region". J. Biol. Chem. 269 (7): 5279-87. PMID 8106512. Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara ... 40 (5): 976-82. PMID 10102295. Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland ... 35 (5-6): 507-11. doi:10.1080/10428199909169615. PMID 10609788. Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (2000 ... Intron-exon organization and functional analysis of 5'- ...
*  Beta adrenergic receptor kinase
... flanking region (> 80%) helps define this region as a CpG island that may be a principal regulator of beta ARK expression. Beta ... flanking/promoter region reveals many features characteristic of mammalian housekeeping genes, i.e. the lack of a TATA box, an ... Functional regions of beta ARK are described with respect to their location within the exon-intron organization of the gene. ... 143 (5): 750-60. doi:10.1016/j.cell.2010.10.018. PMID 21111235. Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (July ...
*  PTK6
... flanking region of the human PTK6 gene". Biochim. Biophys. Acta. 1574 (3): 365-9. doi:10.1016/s0167-4781(02)00234-8. PMID ... 5 (7): 1767-77. PMID 10430081. Derry JJ, Richard S, Valderrama Carvajal H, et al. (2000). "Sik (BRK) Phosphorylates Sam68 in ... Kang KN, Kim M, Pae KM, Lee ST (2002). "Characterization of the 5'- ...
*  ADAMTS4
... flanking region of human aggrecanase-1 (ADAMTS4) gene". Molecular Biology Reports. 27 (3): 167-73. doi:10.1023/A:1007253930568 ... Adjacent to the C-terminal TSR is a disintegrin-like domain, a cysteine-rich region that stacks against the active-site of the ... Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ... 5 (3): 169-76. doi:10.1093/dnares/5.3.169. PMID 9734811. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, ...
*  Factor XII
... flanking region". The Journal of Biological Chemistry. 262 (28): 13662-73. PMID 2888762. Stavrou E, Schmaier AH (Mar 2010). " ... flanking region". The Journal of Biological Chemistry. 262 (28): 13662-73. PMID 2888762. Que BG, Davie EW (Apr 1986). " ... and a proline-rich region, and its light chain contains the protease domain. Recently, the structure of the FnI-EGF-like tandem ... 5 (4): 733-41. doi:10.1586/14779072.5.4.733. PMID 17605651. Harris RJ, Ling VT, Spellman MW (Mar 1992). "O-linked fucose is ...
*  Endothelin A receptor
... flanking region of human genomic ETA gene". Biochemical and Biophysical Research Communications. 190 (2): 332-9. doi:10.1006/ ... 56 Suppl 5: 1303-7. doi:10.1253/jcj.56.supplementv_1303. PMID 1291713. Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, ... Yang H, Tabuchi H, Furuichi Y, Miyamoto C (January 1993). "Molecular characterization of the 5'- ...
*  RGS3
... flanking region, and chromosomal localization of the human RGS3 gene". Genomics. 45 (2): 429-33. doi:10.1006/geno.1997.4929. ... 2002). "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of ... 2002). "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human ...
*  Beta-glucuronidase
... flanking region of the human beta-glucuronidase gene". Genomics. 10 (4): 1009-18. doi:10.1016/0888-7543(91)90192-H. PMID ... Marathe SV, McEwen JE (February 1995). "Vectors with the gus reporter gene for identifying and quantitating promoter regions in ... 2 (6): 443-5. doi:10.1002/humu.1380020604. PMID 8111412. Wu BM, Sly WS (1994). "Mutational studies in a patient with the ...
*  Estrogen receptor alpha
... flanking region of the human estrogen receptor gene". DNA Seq. 2 (6): 347-58. doi:10.3109/10425179209020816. PMID 1476547. Piva ... genomic organization of the human ERalpha gene promoter region". Mol. Endocrinol. 15 (12): 2057-63. doi:10.1210/me.15.12.2057. ... 6 (5): 773-85. doi:10.1210/me.6.5.773. PMID 1603086. Keaveney M, Klug J, Dawson MT, Nestor PV, Neilan JG, Forde RC, Gannon F ( ... 70 (5-7): 361-3. doi:10.1016/j.steroids.2005.02.015. PMID 15862818. Wang CL, Tang XY, Chen WQ, Su YX, Zhang CX, Chen YM (2007 ...
*  Glycoside hydrolase family 59
... flanking region and structural organization". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1395 (1): 62 ...
*  RRM1
... flanking region of the gene". Genomics. 19 (1): 91-6. doi:10.1006/geno.1994.1017. PMID 8188248. Byrne JA, Smith PJ (1993). "The ... This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail ... It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. ... Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, ...
*  Phosducin
... flanking region". Genomics. 19 (2): 369-72. doi:10.1006/geno.1994.1072. PMID 8188267. Sparkes RS, Lee RH, Shinohara T, et al. ( ... 2000). "A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region". ... Abe T, Kikuchi T, Shinohara T (1994). "The sequence of the human phosducin gene (PDC) and its 5'- ...
*  ACTR1A
... flanking region of the coagulation factor VII gene". J. Thromb. Haemost. 1 (6): 1220-7. doi:10.1046/j.1538-7836.2003.00227.x. ... 5 (12): 1301-10. doi:10.1091/mbc.5.12.1301. PMC 301159 . PMID 7696711. Faulkner NE, Vig B, Echeverri CJ, et al. (1998). " ... 113 (5): 877-86. PMID 10671377. Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific ... U.S.A. 92 (5): 1634-8. doi:10.1073/pnas.92.5.1634. PMC 42574 . PMID 7878030. Garces JA, Clark IB, Meyer DI, Vallee RB (1999). " ...
*  Corticotropin-releasing hormone
... flanking region of the human corticotropin releasing hormone gene". DNA Seq. 4 (3): 197-206. doi:10.3109/10425179309015632. ... "Structural analysis of the regulatory region of the human corticotropin releasing hormone gene". FEBS Lett. 267 (1): 1-5. doi: ... 11 (7): 980-5. doi:10.1210/me.11.7.980. PMID 9178757. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V ... 1 (5): 460-3. doi:10.1038/nm0595-460. PMID 7585095. Slominski A, Ermak G, Hwang J, Chakraborty A, Mazurkiewicz JE, Mihm M (1995 ...
*  Galactosylceramidase
... flanking region and structural organization". Biochim. Biophys. Acta. 1395 (1): 62-7. doi:10.1016/S0167-4781(97)00140-1. PMID ... region". Hum. Mutat. 28 (7): 742. doi:10.1002/humu.9500. PMID 17579360. Beier UH; Görögh T (2005). "Implications of ... 5 (9): e12862. doi:10.1371/journal.pone.0012862. PMC 2943476 . PMID 20877624. GeneReviews/NCBI/NIH/UW entry on Krabbe disease ... 1998). "Human galactocerebrosidase gene: promoter analysis of the 5'- ...
*  Follicle-stimulating hormone receptor
... flanking region of the human follicle-stimulating hormone receptor gene". Molecular and Cellular Endocrinology. 102 (1-2): 93- ... Upon initial binding to the LRR region of FSHR, FSH reshapes its conformation to form a new pocket. FSHR then inserts its ... "Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor ... 8 (5): 413-21. doi:10.1093/humupd/8.5.413. PMID 12398222. Delbaere A, Smits G, Olatunbosun O, Pierson R, Vassart G, Costagliola ...
*  TOP3A
... flanking region for the human topoisomerase III gene". The Journal of Biological Chemistry. 273 (40): 26130-7. doi:10.1074/jbc. ... "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse ... "Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and ... 12 (5): 713-28. doi:10.1101/gr.73702. PMC 186594 . PMID 11997338. Wang Y, Lyu YL, Wang JC (Sep 2002). "Dual localization of ...
*  Classical Anatolia
Armenia lay to the north-east of the Anatolian region, on the Armenian highlands to the south and west of the Caucasus. Its ... Pompey's first move was to persuade the Parthians to harass Tigranes' eastern flank. Following Roman tradition he offered ... Anatolia remained one of the most principal regions of the empire during its entire existence. During the reign of Darius the ... Armenia in the 1st century BC formed a mountainous region in eastern Anatolia, bounded to the south by Syria and Mesopotamia ...
*  CYP3A5
... flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7". Biochemical and Biophysical Research Communications. ... 4 (5): 247-59. doi:10.1097/00008571-199410000-00003. PMID 7894497. Lown KS, Kolars JC, Thummel KE, Barnett JL, Kunze KL, ... 6 (5): 379-85. doi:10.1097/00008571-199610000-00001. PMID 8946469. Anttila S, Hukkanen J, Hakkola J, Stjernvall T, Beaune P, ... Check date values in: ,access-date= (help) "Entrez Gene: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5". " ...
Characterization and functional analysis of the 5′-flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene |...  Characterization and functional analysis of the 5′-flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene |...
... flanking region, revealed that the region between −83 and 60 bp upstream of the transcription start site was essential for ... flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene. Keiji HIRABAYASHI, Maho ISHIDA, Masatoshi SUZUKI, Keitaro ... flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene. Keiji HIRABAYASHI, Maho ISHIDA, Masatoshi SUZUKI, Keitaro ... flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene Message Subject (Your Name) has forwarded a page to you from ...
more infohttp://www.biochemj.org/content/382/3/975
Oxygen-evoked changes in transcriptional activity of the 5′-flanking region of the human amiloride-sensitive sodium channel ...  Oxygen-evoked changes in transcriptional activity of the 5′-flanking region of the human amiloride-sensitive sodium channel ...
... flanking region of the human amiloride-sensitive sodium channel (αENaC) gene: role of nuclear factor κB. Deborah L. BAINES, ... flanking regions of the human αENaC gene using luciferase reporter-gene vectors transiently transfected into human adult ... flanking region of the human amiloride-sensitive sodium channel (αENaC) gene: role of nuclear factor κB ... flanking region of the human amiloride-sensitive sodium channel (αENaC) gene: role of nuclear factor κB ...
more infohttp://www.biochemj.org/content/364/2/537
Comparative study of the genomic organization of DNA repeats within the 5′-flanking region of the natural resistance-associated...  Comparative study of the genomic organization of DNA repeats within the 5′-flanking region of the natural resistance-associated...
... flanking region of the natural resistance-associated macrophage protein gene (NRAMP1) between humans and great apes, Mammalian ... "Comparative study of the genomic organization of DNA repeats within the 5′- ... These results show that sequence length variants in the Alu-flanking regions as well as nucleotide substitutions are the most ... flanking region of... Roger, M. ; Sánchez, F.O. ; Schurr, E. 1998-06-01 00:00:00 The human NRAMP1 gene located on Chromosome ( ...
more infohttps://www.deepdyve.com/lp/springer_journal/comparative-study-of-the-genomic-organization-of-dna-repeats-within-j6hVY19TI0
5 flanking region - Wikipedia  5' flanking region - Wikipedia
Flanking SNPs are Single nucleotide polymorphisms (SNP) that appear in the flanking region. Polymorphisms in this region can ... flanking region is a region of DNA that is adjacent to the 5' end of the gene. The 5' flanking region contains the promoter, ... flanking region of eukaryotic genomes. A specific transcription factor called CAAT-binding protein binds to this region and ... untranslated region, this region is neither transcribed into RNA, nor translated into a functional protein. These regions ...
more infohttps://en.wikipedia.org/wiki/5'_flanking_region
A structural variant in the 5-flanking region of the TWIST2 gene affects melanocyte development in belted cattle  A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle
Belted cattle have a circular belt of unpigmented hair and skin around their midsection. The belt is inherited as a monogenic autosomal dominant trait. We mapped the causative variant to a 37 kb segment on bovine chromosome 3. Whole genome sequence data of 2 belted and 130 control cattle yielded only one private genetic variant in the critical interval in the two belted animals. The belt-associated variant was a copy number variant (CNV) involving the quadruplication of a 6 kb non-coding sequence located approximately 16 kb upstream of the TWIST2 gene. Increased copy numbers at this CNV were strongly associated with the belt phenotype in a cohort of 333 cases and 1322 controls. We hypothesized that the CNV causes aberrant expression of TWIST2 during neural crest development, which might negatively affect melanoblasts. Functional studies showed that ectopic expression of bovine TWIST2 in neural crest in transgenic zebrafish led to a decrease in melanocyte numbers. Our results thus implicate an
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180170
5 Flanking Region | Profiles RNS  5' Flanking Region | Profiles RNS
Flanking Region" was a major or minor topic of these publications. To see the data from this visualization as text, click here. ... Flanking Region" by people in Profiles.. * Bruschweiler-Li L, Fuentes Medel YF, Scofield MD, Trang EB, Binke SA, Gardner PD. ... Flanking Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... Flanking Region" by people in this website by year, and whether "5' ...
more infohttps://profiles.umassmed.edu/display/116511
Common carp insulin-like growth factor-I gene: complete nucleotide sequence and functional characterization of the 5-flanking...  Common carp insulin-like growth factor-I gene: complete nucleotide sequence and functional characterization of the 5'-flanking...
... flanking region of the common carp IGF-I gene by performing luciferase reporter assays in transfected 293GHR cells. Addition of ... flanking region from a local tropical fish, the common carp (Cyprinus carpio), and characterized its promoter activity by ... However, sequence analysis of the common carp IGF-I promoter region identified several consensus liver-enriched transcription ... we have cloned and completely sequenced the IGF-I gene and the 5'- ...
more infohttps://www.garvan.org.au/research/publications/1742
Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5-flanking region.  Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region.
... flanking region.. Gomez M., Manzano A., Navarro-Sabate A., Duran J., Obach M., Perales J.C., Bartrons R. ... flanking region by transient transfection assays with different 5'-deletion promoter constructs in GC-1spg and mouse sertoli ... Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'- ...
more infohttps://www.uniprot.org/citations/15642344
Phenobarbital responsiveness conferred by the 5-flanking region of the rat CYP2B2 gene in transgenic mice.  - PubMed - NCBI  Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice. - PubMed - NCBI
... flanking region of the rat CYP2B2 gene in transgenic mice.. Ramsden R1, Beck NB, Sommer KM, Omiecinski CJ. ... flanking region of the rat CYP2B2 gene. Protein-DNA interactions at the PBRU domain also were characterized. Using the ... flanking CYP2B2 sequence are not PB responsive. DNA affinity enrichment techniques and immunoblotting and electromobility shift ... gene reporters to assess the functional consequences of specific deletions and site-specific mutations within the 2.5kb 5'- ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10072770?dopt=Abstract
Separation of cis elements responsive to ethylene, fruit development, and ripening in the 5′-flanking region of the ripening...  Separation of cis elements responsive to ethylene, fruit development, and ripening in the 5′-flanking region of the ripening...
We have identified a 428 bp fragment of the E8 5'-flanking region, from -1528 to -1100,... ... Deikman J, Fischer RL: Interaction of a DNA binding factor with the 50-flanking region of an ethylene-responsive fruit ripening ... Coupe SA, Deikman J: Characterization of a DNA-binding protein that interacts with 50-flanking regions of two fruitripening ... flanking region, from -1528 to -1100, that makes a minimal 35S promoter responsive to ethylene. This fragment confers ethylene- ...
more infohttps://link.springer.com/article/10.1023%2FA%3A1006091928367
DIGITAL.CSIC: Characterization of sea bass FSHβ 5′ flanking region: Transcriptional control by 17β-estradiol  DIGITAL.CSIC: Characterization of sea bass FSHβ 5flanking region: Transcriptional control by 17β-estradiol
... flanking region: Transcriptional control by 17β-estradiol. Authors: Muriach, Borja ; Carrillo, Manuel ; Zanuy, Silvia ; Cerdá- ... flanking region (sbFSHβ 5′ FR) was cloned and characterized in order to study the molecular mechanisms underlying ... Analysis of the ~3.5 kb of this region revealed the presence of several putative cis-acting elements, including steroid hormone ... The sbFSHβ 5′ FR was efficiently expressed under basal conditions in LβT2 but not in HEK 293, pointing to both positive and ...
more infohttp://digital.csic.es/handle/10261/144066
A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B genes 5-Flanking Region is Associated with...  A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene's 5'-Flanking Region is Associated with...
Flanking Region is Associated with Essential Hypertension among Japanese Females. Int J Med Sci 2007; 4(3):146-152. doi:10.7150 ... flanking region of natriuretic peptide precursor B (NPPB) gene and assessed the relationship between gene variants and EH. ... Flanking Region is Associated with Essential Hypertension among Japanese Females Kotoko Kosuge1, Masayoshi Soma1,3, Tomohiro ... flanking region of NPPB appears to be a useful genetic marker of EH in females. ...
more infohttp://www.medsci.org/v04p0146
Polymorphisms in the 5 Flanking Region and First Exon of Insulin-Like Growth Factor 1 Gene in Southern Populations of Buffalo ...  Polymorphisms in the 5' Flanking Region and First Exon of Insulin-Like Growth Factor 1 Gene in Southern Populations of Buffalo ...
Flanking Region was amplified and subsequently subjected to Single Strand Conformation Polymorphism (SSCP). The results were ... Also, the 265 bp of IGF-1 promoter in the 5' ... Flanking Region and First Exon of Insulin-Like Growth Factor 1 ... Flanking Region was amplified and subsequently subjected to Single Strand Conformation Polymorphism (SSCP). The results were ... Also, the 265 bp of IGF-1 promoter in the 5' ...
more infohttp://thescipub.com/abstract/10.3844/ajbbsp.2013.348.354
Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5 flanking region drives LacZ expression in podocytes. -...  Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes. -...
... flanking promoter sequence were identified and characterized. Two constructs were generated by placing a bacterial lacZ ... An 8.3-kb and a 5.4-kb fragment containing the 5' ... flanking region drives LacZ expression in podocytes.. @article{ ... flanking region drives LacZ expression in podocytes.}, author={Marcus M{\'o}ller and Iulia A. Kovari and Lawrence B. Holzman}, ... Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' ...
more infohttps://www.semanticscholar.org/paper/Evaluation-of-a-new-tool-for-exploring-podocyte-5%27-M%C3%B6ller-Kovari/22e5705042d13be38f597da6805a84fe38519f17
Hypervariable area in the 5 flanking region of GSTP1, previously reported as a minisatellite repeat | Breast Cancer Research |...  Hypervariable area in the 5' flanking region of GSTP1, previously reported as a minisatellite repeat | Breast Cancer Research |...
... flanking region of GSTP1, previously reported as a minisatellite repeat. ... untranslated region is further degenerated by insertions of CAC, ATT and other motifs, and describe a detailed analysis of the ... untranslated region immediately upstream of an extensively methylated CpG island. Poly AT-rich repeats are implicated as ... Two polymorphisms in GSTP1 are known: a point mutation in exon 5 with a possible functional role, leading to changes in the ...
more infohttps://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr177
Activated 5′ flanking region of NANOGP8 in a self-renewal environment...  Activated 5flanking region of NANOGP8 in a self-renewal environment...
... flanking region of NANOGP8 in a self-renewal environment is associated with increased sphere formation and tumor growth of ... flanking region of NANOGP8 in a self-renewal environment is associated with increased sphere formation and tumor growth of ... flanking region of NANOGP8 exhibited enhanced clonogenicity, sphere formation, and xenograft tumor growth. The sphere culture ... flanking region of NANOGP8. Forced expression of NANOGP8 increased the entry into the cell cycle. ...
more infohttps://empiregenomics.com/news/article/activated
Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in...  Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in...
... flanking region for the gene expression in activated T lymphocytes ... flanking region of the human gene. Analysis of nucleotide sequences in the 5'-flanking region of the human elastin gene ... Hanson, R.D.; Sclar, G.M.; Kanagawa, O.; Ley, T.J., 1991: The 5'-flanking region of the human CGL-1/granzyme B gene ... Haase, A.; Stoffel, W., 1990: The 3'-flanking region shared by the human apolipoprotein AI and CIII gene regulates gene ...
more infohttps://eurekamag.com/research/041/211/041211108.php
Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5-flanking region. :...  Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region. :...
Flanking Region A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of ... Flanking Region A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of ... Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region. ... Regulation of Human Cytochrome P4501A2 Gene (CYP1A2) Expression: Isolation and Functional Analysis of the 5'- ...
more infohttp://libarchive.dartmouth.edu/cdm/compoundobject/collection/dcdis/id/278295/rec/7
Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5-flanking region. :...  Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region. :...
Flanking Region A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of ... Flanking Region A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of ... Regulation of human cytochrome P4501A2 gene (CYP1A2) expression: isolation and functional analysis of the 5'-flanking region. ... Regulation of Human Cytochrome P4501A2 Gene (CYP1A2) Expression: Isolation and Functional Analysis of the 5'- ...
more infohttp://libarchive.dartmouth.edu/cdm/compoundobject/collection/dcdis/id/278295/rec/6
Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for...  Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for...
Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for ...
more infohttp://scholar.sun.ac.za/handle/10019.1/76717
  • Schurr, E. 1998-06-01 00:00:00 The human NRAMP1 gene located on Chromosome (Chr) region 2q35 is a candidate gene for increased risk of infection by several intracellular macrophage parasites, including M. tuberculosis and M. leprae. (deepdyve.com)
  • We investigate clonogenicity, sphere formation, and xenograft tumor growth of prostate cancer cells with an activated 5flanking region of NANOGP8. (empiregenomics.com)
  • The sphere culture and tumor initiation mouse mode promoted the activation of the 5flanking region of NANOGP8. (empiregenomics.com)
  • The activation of 5flanking sequence of NANOGP8 could play a role in the regulation of the stem-like properties of cancer stem cells and prostate tumor initiation and development. (empiregenomics.com)
  • Mahony, D and Stringer, BW and Dickinson, JL and Antalis, TM, DNase I hypersensitive sites in the 5 ' flanking region of the human plasminogen activator inhibitor type 2 (PAI-2) gene are associated with basal and tumor necrosis factor-alpha-induced transcription in monocytes, European Journal of Biochemistry, 256, (3) pp. 550-559. (edu.au)
  • M-ASGP-BP is expressed on the surface of activated macrophages, recognizes terminal galactose/ N -acetylgalactosamine units, and may participate in the interaction between tumoricidal macrophages and tumor cells ( 3 , 4 , 5 ). (jimmunol.org)
  • To understand the molecular mechanism which controls the transcription of the IGF-I gene in common carp, we have cloned and completely sequenced the IGF-I gene and the 5'-flanking region from a local tropical fish, the common carp (Cyprinus carpio), and characterized its promoter activity by transfection into human embryonic kidney (293GHR) cells which express the human growth hormone (GH) receptor. (garvan.org.au)
  • As an initial step towards understanding the molecular mechanisms underlying PAI-2 gene regulation in monocytes, we report here the analysis of the chromatin structure of 9.6 kb of 5' flanking region of the human PAI-2 gene for potential cis-acting regulatory regions using DNase I hypersensitivity mapping. (edu.au)
  • 1 , 3 , 5 Animal models became resistant to the induction of EAMG when circulating complement was either depleted by cobra venom toxin or functionally inhibited by the administration of a monoclonal C5 antibody or soluble C1 receptor. (pubmedcentralcanada.ca)
  • Deikman J, Fischer RL: Interaction of a DNA binding factor with the 50-flanking region of an ethylene-responsive fruit ripening gene from tomato. (springer.com)
  • Furthermore, we provide evidence for bidirectional MBS85 promoter activity and demonstrate that the minimal motifs required for AAV site-specific integration are present in the 5′ untranslated region of the gene and play a posttranscriptional role in the regulation of MBS85 expression. (pubmedcentralcanada.ca)
  • Fibroblast growth factor 23 (FGF23) is a recently discovered phosphaturic hormone ( 1 - 5 ). (asnjournals.org)