5-Aminolevulinate Synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Aminolevulinic Acid
Porphobilinogen Synthase
Anemia, Sideroblastic
Glutamate-Ammonia Ligase
Amino Acyl-tRNA Synthetases
2',5'-Oligoadenylate Synthetase
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
Hydroxymethylbilane Synthase
An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen (UROPORPHYRINOGENS) in several discrete steps. It is the third enzyme in the 8-enzyme biosynthetic pathway of HEME. In humans, deficiency in this enzyme encoded by HMBS (or PBGD) gene results in a form of neurological porphyria (PORPHYRIA, ACUTE INTERMITTENT). This enzyme was formerly listed as EC 4.3.1.8
Boranes
Hemin
Allylisopropylacetamide
Dicarbethoxydihydrocollidine
Rhodobacter capsulatus
Heme
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genetic Diseases, X-Linked
Peptide Synthases
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Schiff Bases
Ferrochelatase
Base Sequence
Intramolecular Transferases
Amino Acid Sequence
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Pyridoxal
Ligases
Erythroblasts
Aspartate-tRNA Ligase
Methionine-tRNA Ligase
Tryptophan-tRNA Ligase
Iron-Regulatory Proteins
Carbon-Nitrogen Ligases
Protoporphyrins
Isoleucine-tRNA Ligase
Aspartate-Ammonia Ligase
Glycine
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Pyridoxine
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Phenylalanine-tRNA Ligase
Photochemotherapy
Spectrophotometry
Carbamoyl-Phosphate Synthase (Ammonia)
Circular Dichroism
Cloning, Molecular
Argininosuccinate Synthase
Acetate-CoA Ligase
Enzyme Induction
delta-Aminolevulinate synthetases in the liver cytosol fraction and mitochondria of mice treated with allylisopropylacetamide and 3,5-dicarbethoxyl-1,4-dihydrocollidine. (1/369)
Hepatic delta-aminolevulinate (ALA) synthetase was induced in mice by the administration of allylisopropylacetamide (AIA) and 3,5-dicarbethoxy-1,4-dihydrocollidine (DDC). In both cases, a significant amount of ALA synthetase accumulated in the liver cytosol fraction as well as in the mitochondria. The apparent molecular weight of the cytosol ALA synthetase was estimated to be 320,000 by gel filtration, but when the cytosol ALA synthetase was subjected to sucrose density gradient centrifugation, it showed a molecular weight of 110,000. In the mitochondria, there were two different sizes of ALA synthetase with molecular weights of 150,000 and 110,000, respectively; the larger enzyme was predominant in DDC-treated mice, whereas in AIA-treated mice and normal mice the enzyme existed mostly in the smaller form. When hemin was injected into mice pretreated with DDC, the molecular size of the mitochondrial ALA synthetase changed from 150,000 to 110,000. The half-life of ALA synthetase in the liver cytosol fraction was about 30 min in both the AIA-treated and DDC-treated mice. The half-life of the mitochondrial ALA synthetase in AIA-treated mice and normal mice was about 60 min, but in DDC-treated mice the half-life was as long as 150 min. The data suggest that the cytosol ALA synthetase of mouse liver is a protein complex with properties very similar to those of the cytosol ALA synthetase of rat liver, which has been shown to be composed of the enzyme active protein and two catalytically inactive binding proteins, and that ALA synthetase may be transferred from the liver cytosol fraction to the mitochondria with a size of about 150,000 daltons, followed by its conversion to enzyme with a molecular weight of 110,000 within the mitochondria. The process of intramitochondrial enzyme degradation seems to be affected in DDC-treated animals. (+info)Four new mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causing X-linked sideroblastic anemia: increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary hemochromatosis. (2/369)
X-linked sideroblastic anemia (XLSA) in four unrelated male probands was caused by missense mutations in the erythroid-specific 5-aminolevulinate synthase gene (ALAS2). All were new mutations: T647C, C1283T, G1395A, and C1406T predicting amino acid substitutions Y199H, R411C, R448Q, and R452C. All probands were clinically pyridoxine-responsive. The mutation Y199H was shown to be the first de novo XLSA mutation and occurred in a gamete of the proband's maternal grandfather. There was a significantly higher frequency of coinheritance of the hereditary hemochromatosis (HH) HFE mutant allele C282Y in 18 unrelated XLSA hemizygotes than found in the normal population, indicating a role for coinheritance of HFE alleles in the expression of this disorder. One proband (Y199H) with severe and early iron loading coinherited HH as a C282Y homozygote. The clinical and hematologic histories of two XLSA probands suggest that iron overload suppresses pyridoxine responsiveness. Notably, reversal of the iron overload in the Y199H proband by phlebotomy resulted in higher hemoglobin concentrations during pyridoxine supplementation. The proband with the R452C mutation was symptom-free on occasional phlebotomy and daily pyridoxine. These studies indicate the value of combined phlebotomy and pyridoxine supplementation in the management of XLSA probands in order to prevent a downward spiral of iron toxicity and refractory anemia. (+info)Properties of 5-aminolaevulinate synthetase and its relationship to microsomal mixed-function oxidation in the southern armyworm (Spodoptera eridania). (3/369)
1. Activity of 5-aminolaevulinate synthetase was measured in the midgut and other tissues of the last larval instar of the southern armyworm (Spodoptera eridania Cramer, formerly Prodenia eridania Cramer). 2. Optimum conditions for measuring the activity were established with respect to all variables involved and considerable differences from those reported for mammalian enzyme preparations were found. 3. Maximum activity (20 nmol/h per mg of protein) occurs 18-24 h after the fifth moult and thereafter decreases to trace amounts as the larvae age and approach pupation. 4. Synthetase activity was rapidly induced by oral administration (in the diet) of pentamethylbenzene, phenobarbital, diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3, 5-dicarboxylate, and 2-allyl-2-isopropylacetamide. 5. Puromycin inhibited the induction of synthetase by pentamethylbenzene. 6. Induction of 5-aminolaevulinate synthetase correlated well with the induction of microsomal N-demethylation of p-chloro-N-methylaniline, except for phenobarbital, which induced the microsomal oxidase relatively more than the synthetase. (+info)Pre-steady-state reaction of 5-aminolevulinate synthase. Evidence for a rate-determining product release. (4/369)
5-Aminolevulinate synthase (ALAS) is the first enzyme of the heme biosynthetic pathway in non-plant eukaryotes and the alpha-subclass of purple bacteria. The pyridoxal 5'-phosphate cofactor at the active site undergoes changes in absorptive properties during substrate binding and catalysis that have allowed us to study the kinetics of these reactions spectroscopically. Rapid scanning stopped-flow experiments of murine erythroid 5-aminolevulinate synthase demonstrate that reaction with glycine plus succinyl-CoA results in a pre-steady-state burst of quinonoid intermediate formation. Thus, a step following binding of substrates and initial quinonoid intermediate formation is rate-determining. The steady-state spectrum of the enzyme is similar to that formed in the presence of 5-aminolevulinate, suggesting that release of this product limits the overall rate. Reaction of either glycine or 5-aminolevulinate with ALAS is slow (kf = 0.15 s-1) and approximates kcat. The rate constant for reaction with glycine is increased at least 90-fold in the presence of succinyl-CoA and most likely represents a slow conformational change of the enzyme that is accelerated by succinyl-CoA. The slow rate of reaction of 5-aminolevulinate with ALAS is 5-aminolevulinate-independent, suggesting that it also represents a slow isomerization of the enzyme. Reaction of succinyl-CoA with the enzyme-glycine complex to form a quinonoid intermediate is a biphasic process and may be irreversible. Taken together, the data suggest that turnover is limited by release of 5-aminolevulinate or a conformational change associated with 5-aminolevulinate release. (+info)Phylogenetic analysis of the 5-aminolevulinate synthase gene. (5/369)
The evolution of 5-aminolevulinate synthase (ALS) was studied by acquiring sequence data and generating phylogenetic trees. Gene sequences were already available for a variety of vertebrates (which have both a housekeeping and an erythroid form of the gene), fungi, alpha-proteobacteria, and one protist and one protostome. In order to generate representative trees, ALS sequence data were acquired from various deuterostomes and protostomes. The species and tissues selected for study were beluga whale liver, hagfish blood, sea urchin gonadal tissue, cuttlefish hepatopancreas, horseshoe crab hepatopancreas, and bloodworm blood. The new sequences and those previously published were examined for the presence of heme-regulatory motifs (HRMs) and iron-responsive elements (IREs). The HRMs are present in almost all eukaryotic species, which suggests their fundamental role in the regulation of ALS. The IREs are present in all vertebrate erythroid forms of ALS, which indicates that in those animals, expression of the erythroid form of the enzyme and, hence, hemoglobin production can be influenced by the intracellular content of iron. The new sequences were aligned with previously reported ALS sequences, and phylogenetic analyses were performed. The resulting trees provided evidence regarding the timing of the gene duplication event that led to the two forms of the ALS gene in vertebrates. It appears that the housekeeping and erythroid forms of ALS probably arose before the divergence of hagfish from the deuterostome line leading to the vertebrates. The data also add to the evidence indicating that alpha-proteobacteria are the nearest contemporary relatives of mitochondria. (+info)Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells. (6/369)
Nuclear respiratory factor (NRF)-1 appears to be important for the expression of several respiratory genes, but there is no direct evidence that NRF-1 transduces a physiological signal into the production of an enzyme critical for mitochondrial biogenesis. We generated HeLa cells containing plasmids allowing doxycycline-inducible expression of uncoupling protein (UCP)-1. In the absence of doxycycline, UCP-1 mRNA and protein were undetectable. In the presence of doxycycline, UCP-1 was expressed and oxygen consumption doubled. This rise in oxygen consumption was associated with an increase in NRF-1 mRNA. It was also associated with an increase in NRF-1 protein binding activity as determined by electrophoretic mobility shift assay using a functional NRF-1 binding site from the delta-aminolevulinate (ALA) synthase promoter. Respiratory uncoupling also caused a time-dependent increase in protein levels of ALA synthase, an early marker for mitochondrial biogenesis. ALA synthase induction by respiratory uncoupling was prevented by transfecting cells with an oligonucleotide antisense to the region of the NRF-1 initiation codon; a scrambled oligonucleotide with the same base composition had no effect. Respiratory uncoupling increases oxygen consumption and lowers energy reserves. In HeLa cells, uncoupling also increases ALA synthase, an enzyme critical for mitochondrial respiration, but only if translatable mRNA for NRF-1 is available. These data suggest that the transcription factor NRF-1 plays a key role in cellular adaptation to energy demands by translating physiological signals into an increased capacity for generating energy. (+info)Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli. (7/369)
The hemA and hemT genes encoding 5-aminolaevulinic acid synthase (ALAS) from the photosynthetic bacterium Rhodobacter sphaeroides, were cloned to allow high expression in Escherichia coli. Both HemA and HemT appeared to be active in vivo as plasmids carrying the respective genes complemented an E. coli hemA strain (glutamyl-tRNA reductase deficient). The over-expressed isoenzymes were isolated and purified to homogeneity. Isolated HemA was soluble and catalytically active whereas HemT was largely insoluble and failed to show any activity ex vivo. Pure HemA was recovered in yields of 5-7 mg x L-1 of starting bacterial culture and pure HemT at 10 mg x L-1 x HemA has a final specific activity of 13 U x mg-1 with 1 unit defined as 1 micromol of 5-aminolaevulinic acid formed per hour at 37 degrees C. The Km values for HemA are 1.9 mM for glycine and 17 microM for succinyl-CoA, with the enzyme showing a turnover number of 430 h-1. In common with other ALASs the recombinant R. sphaeroides HemA requires pyridoxal 5'-phosphate (PLP) as a cofactor for catalysis. Removal of this cofactor resulted in inactive apo-ALAS. Similarly, reduction of the HemA-PLP complex using sodium borohydride led to > 90% inactivation of the enzyme. Ultraviolet-visible spectroscopy with HemA suggested the presence of an aldimine linkage between the enzyme and pyridoxal 5'-phosphate that was not observed when HemT was incubated with the cofactor. HemA was found to be sensitive to reagents that modify histidine, arginine and cysteine amino acid residues and the enzyme was also highly sensitive to tryptic cleavage between Arg151 and Ser152 in the presence or absence of PLP and substrates. Antibodies were raised to both HemA and HemT but the respective antisera were not only found to bind both enzymes but also to cross-react with mouse ALAS, indicating that all of the proteins have conserved epitopes. (+info)A photosensitising adenovirus for photodynamic therapy. (8/369)
We have developed a new approach to photodynamic therapy based on adenoviral transduction of the rate-limiting enzyme in heme synthesis. Conventional phototherapy uses porphyrin-based chemical photosensitisers, including delta-aminolaevulinic acid (ALA) which is converted to protoporphyrin IX (PpIX) by the enzymes of the heme biosynthetic pathway. The lack of a specific mechanism for targeting chemical photosensitisers and PpIX to tumour cells means that therapeutic irradiation can damage normal tissue and exposure to sunlight following treatment can cause severe burns. The rate limiting enzyme in PpIX synthesis is ALA-synthase (ALA-S). We have developed a new yeast vector system for manipulation of the adeno- virus genome and used it to construct a virus expressing a mutant form of ALA-S lacking the iron response elements which regulate ALA-S translation and the heme regulatory motifs which regulate import of ALA-S into mitochondria. The virus induces a large increase in PpIX expression and confers photosensitivity on cultured cells. Unlike conventional photodynamic therapy, a viral approach makes it possible to restrict photosensitivity by biological rather than purely physical or chemical means. As with HSV thymidine kinase, ALA-S expression is a general mechanism for sensitisation to a therapeutic agent which can easily be adapted to whatever means of gene delivery is most effective. (+info)
Effect of endotoxin on tryptophan pyrrolase and delta-aminolaevulinate synthase: evidence for an endogenous regulatory haem...
Induction of hepatic δ-aminolevulinate synthase and cytochrome P-450 by a thiazide diuretic<...
Methyl aminolevulinate photodynamic therapy | DermNet NZ
Methyl Aminolevulinate Topical - Side Effects, Dosage, Interactions - Drugs - Everyday Health
Methyl Aminolevulinate (Topical Application Route) Side Effects - Mayo Clinic
XLSA - X-Linked Sideroblastic Anemia | AcronymFinder
Congenital Sideroblastic Anemia | Boston Childrens Hospital
Pyridoxine-responsive primary acquired sideroblastic anaemia : in vitro and in vivo effects of vitamin B6 on decreased 5...
Aminolevulinic acid synthase - Wikipedia
Iron loading of cultured hepatocytes. Effect of iron on 5-aminolaevulinate synthase is independent of lipid peroxidation |...
An infant with Pearson syndrome: a rare cause of congenital sideroblastic anemia and bone marrow failure | Blood Journal
sideroblastic anemia
Best Sideroblastic Anemia Doctor in Kolkata, Sideroblastic Anemia Doctors | Credihealth
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses,...
Human Aminolevulinate Delta Dehydratase (ALAD) ELISA Kit, Cat#EKU02314 - Biomatik
Long-term sucrose and glucose consumption decreases the δ-aminolevulinate dehydratase activity in mice
August 2017 - Small-Molecule Inhibitors of Protein Interactions
Sideroblastic Anemias - Hematology and Oncology - Merck Manuals Professional Edition
ANEMIA, SIDEROBLASTIC, 3, PYRIDOXINE-REFRACTORY; SIDBA3 | MENDELIAN.CO
Erythropoietic porphyria - Wikipedia
The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic...
Idiopathic sideroblastic anemia | definition of idiopathic sideroblastic anemia by Medical dictionary
Sideroblastic Anemia. Basic Information, Causes, Diagnosis and Treatment of Sideroblastic Anemia
ALAS2 gene - Genetics Home Reference - NIH
Hereditary sideroblastic anemia
Comparative study of effect of inorganic lead and cadmium on blood δ-aminolevulinate dehydratase in man | Occupational &...
Gene Responsible For A Rare Form Of Congenital Anemia Identified
JCI -
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia
Anemia, sideroblastic, pyridoxine-refractory autosomal recessive | definition of anemia, sideroblastic, pyridoxine-refractory...
ICD-10 Diagnosis Code D64.0 Hereditary sideroblastic anemia
SACOL RS12725 - AureoWiki
Anemia, Sideroblastic | 5-Minute Clinical Consult
Youbet, Betandwin, Admiral, Sportingbet - Beiträge pro Seite
Sideroblastic anemia -...
Pearson syndrome in an infant heterozygous for C282Y allele of HFE gene.
FA Biochemistry Heme Synthesis Flashcards - Cram.com
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to...
Eldorado: Δ-Aminolevulinate dehydratase and glutathione peroxidase activity in Alzheimers disease
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British Library EThOS: Structure and function of tetrapyrrole biosynthesis enzymes: ALA synthase and cobalt chelatase
Sideroblastic Anemia
Macrocytic Anemia in Manifesting Females<...
Subcellular Localization of Iron and Heme Metabolism Related Proteins at Early Stages of Erythrophagocytosis - pdf descargar
HS Codes - Taiwan vi 28.13.90 - Commerical phosphorus trisulphide
Human ALAD adenoviral particles Shirley - Science Marketplace
Refdoc
Reactome | Heme biosynthesis
길랑 바레 증후군으로 오인된 중증의 감각운동 다발성 신경병증 환자에서 급성 간헐 포르피린증 선별의 중요성: 증례 보고
Plus it
Determination of delta-aminolevulinic acid in blood plasma and urine by gas-liquid chromatography. - Semantic Scholar
Differential effects of mitomycin C on constitutive and inducible gene expression in the chick embryo liver in vivo:...
Primary acquired sideroblastic erythropoiesis in non-anaemic and minimally anaemic subjects. | Journal of Clinical Pathology
THE DYSPLASTIC AND SIDEROBLASTIC ANEMIAS | Hematology in Clinical Practice, 5e | AccessHemOnc | McGraw-Hill Medical
THE DYSPLASTIC AND SIDEROBLASTIC ANEMIAS | Hematology in Clinical Practice, 5e | AccessBiomedical Science | McGraw-Hill Medical
Tiffany PUSH PLAY School Boy Humor | OCEANUP TEEN GOSSIP
Ferrochelatase
... succinyl-CoA synthetase, and mitoferrin-1. Multiple studies have suggested the existence of an oligomeric complex that enables ... 269 (1): 390-5. PMID 8276824. Wang X, Poh-Fitzpatrick M, Carriero D, Ostasiewicz L, Chen T, Taketani S, Piomelli S (April 1993 ... 89 (1): 281-5. doi:10.1073/pnas.89.1.281. PMC 48220. PMID 1729699. Lamoril J, Boulechfar S, de Verneuil H, Grandchamp B, ... 378 (5): 1074-1083. doi:10.1016/j.jmb.2008.03.040. PMC 2852141. PMID 18423489. Bencze, Krisztina Z.; Yoon, Taejin; Mill?n- ...
List of MeSH codes (D08)
... amino acyl-trna synthetases MeSH D08.811.464.263.200.050 - alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ... atp synthetase complexes MeSH D08.811.913.696.650.150.500 - proton-translocating atpases MeSH D08.811.913.696.650.150.500.249 ... fatty acid synthetase complex MeSH D08.811.600.391 - glycine decarboxylase complex MeSH D08.811.600.391.100 - ... uroporphyrinogen iii synthetase MeSH D08.811.520.241.700 - polysaccharide-lyases MeSH D08.811.520.241.700.350 - chondroitinases ...
SUCLA2
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha ... Succinyl-CoA synthetase SUCLG1 SUCLG2 GRCh38: Ensembl release 89: ENSG00000136143 - Ensembl, May 2017 GRCm38: Ensembl release ... Furuyama K, Sassa S (March 2000). "Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is ... Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2), also known as ADP-forming succinyl-CoA synthetase (SCS- ...
Annimycin
The gene ann1 encode for an ATP-dependent amide synthetase and is predicted to condense the amine of the C5N group with the ... More over module 5 contains a dehydratase (DH) domain that is not functional. Kalan, Lindsay; Gessner, Arne; Thaker, Maulik N ... The ann5 gene product is organized in modules 4 a 5, the latter terminating with a thioesterase domain. One of the most ... The ann2 gene encode for a 5-aminolevulinate synthase which condenses glycine and succinyl-CoA in a Claisen-like reaction to ...
Chromosome 9
... argininosuccinate synthetase BNC2: zinc finger protein basonuclin-2 C9orf64: chromosome 9 open reading frame 64 C9orf78: ... aminolevulinate, delta-, dehydratase ALS4: amyotrophic lateral sclerosis 4 ANGPTL2: angiopoietin-related protein 2 ASS: ... 5 (2): 157-74. doi:10.1089/109065701753145664. PMID 11551106. Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and ... 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615. "Statistics & Downloads for chromosome 9". HUGO Gene ...
Chromosome 3
LARS2: leucyl-tRNA synthetase, mitochondrial. *LIMD1: LIM domain-containing protein 1. *LINC00312: Long intergenic non-protein- ... ALAS1: aminolevulinate, delta-, synthase 1. *APEH: encoding enzyme Acylamino-acid-releasing enzyme ... doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615.. *^ "Statistics & Downloads for chromosome 3". HUGO Gene Nomenclature ... So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[5] ...
ALAS2
Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein that in humans is encoded by the ALAS2 gene. ALAS2 is an ... Furuyama K, Sassa S (Mar 2000). "Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is ... "Entrez Gene: Delta-aminolevulinate synthase 2". CS1 maint: discouraged parameter (link) Han L, Zhong Y, Huang B, Han L, Pan L, ... Bishop DF, Henderson AS, Astrin KH (Jun 1990). "Human delta-aminolevulinate synthase: assignment of the housekeeping gene to ...
Chromosome 3
Partial list of the genes located on p-arm (short arm) of human chromosome 3: ALAS1: aminolevulinate, delta-, synthase 1 APEH: ... leucyl-tRNA synthetase, mitochondrial LIMD1: LIM domain-containing protein 1 LINC00312: Long intergenic non-protein-coding RNA ... 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615. "Statistics & Downloads for chromosome 3". HUGO Gene ... ETS variant 5 FAM43A: family with sequence similarity 43 member A FAM162A: family with sequence similarity 162 member A GYG1: ...
Porphyria cutanea tarda
Additionally, alcohol has been shown to increase the activity of the delta-aminolevulinic acid synthetase (ALA synthetase), the ... 14 (38): 5913-5. doi:10.3748/wjg.14.5913. PMC 2751904. PMID 18855993. Sökmen, M; Demirsoy, H; Ersoy, O; Gökdemir, G; Akbayir, N ... 18 (3): 200-5. PMID 17891697. Frank, J; Poblete-Gutiérrez, P; Weiskirchen, R; Gressner, O; Merk, H. F.; Lammert, F (2006). " ... 58 (5): 1089-97. doi:10.1172/JCI108560. PMC 333275. PMID 993332. Di Padova, C.; Marchesi, L.; Cainelli, T.; Gori, G.; Podenzani ...
Actinic keratosis
AKs are one of the most common dermatologic lesions for which photodynamic therapy, including topical methyl aminolevulinate ( ... destroys AKs by blocking methylation of thymidylate synthetase, thereby interrupting DNA and RNA synthesis. This in turn ... Topical 5-FU is the most utilized treatment for AK, and often results in effective removal of the lesion. Overall, there is a ... 5-FU may be up to 90% effective in treating non-hyperkeratotic lesions. While topical 5-FU is a widely used and cost-effective ...
Bleomycin
... which is made of both nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) modules. Nonribosomal peptides and ... Pingyangmycin (Bleomycin A5). References[edit]. *^ a b c d e f g h i j k l m n o p q r "Bleomycin Sulfate". The American ... 3-{[(2'-{(5S,8S,9S,10R,13S)-15-{6-amino-2- [(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl] -5- ... 5: 13419. doi:10.1038/srep13419. PMC 4542162. PMID 26289670. Archived from the original on 2016-05-03. In our studies, mice ...
Erythroid 5-aminolevulinate synthetase deficiency | Article about Erythroid 5-aminolevulinate synthetase deficiency by The Free...
Looking for Erythroid 5-aminolevulinate synthetase deficiency? Find out information about Erythroid 5-aminolevulinate ... synthetase deficiency. A usually hereditary, pathologic disorder of porphyrin metabolism characterized by porphyrinuria and ... The little-known disease porphyria is... Explanation of Erythroid 5-aminolevulinate synthetase deficiency ... redirected from Erythroid 5-aminolevulinate synthetase deficiency). Also found in: Dictionary, Thesaurus, Medical. porphyria. [ ...
KEGG BRITE: KEGG Orthology (KO) - Mus musculus (mouse)
67417 Ears2; glutamyl-tRNA synthetase 2, mitochondrial 107508 Eprs; glutamyl-prolyl-tRNA synthetase 17025 Alad; aminolevulinate ... glutamyl-tRNA synthetase [EC:6.1.1.17] K14163 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15] K01698 ... 15159 Hccs; holocytochrome c synthetase 12870 Cp; ceruloplasmin 15203 Heph; hephaestin 14297 Fxn; frataxin K00643 E2.3.1.37; 5- ... 22247 Umps; uridine monophosphate synthetase 17960 Nat1; N-acetyl transferase 1 17961 Nat2; N-acetyltransferase 2 (arylamine N- ...
Frontiers | Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites:...
... was used to unravel the diversity and phylogeny of genes encoding 5-aminolevulinic acid synthases (ALASs, hemA gene products) ... was used to unravel the diversity and phylogeny of genes encoding 5-aminolevulinic acid synthases (ALASs, hemA gene products) ... Mayer, S. M., and Beale, S. I. (1992). Succinyl-coenzyme A synthetase and its role in delta-aminolevulinic acid biosynthesis in ... This specifically concerns hemA alleles encoding cyclizing type of aminolevulinate synthase, as a part of the C5N-encoding gene ...
Ferrochelatase - Wikipedia
... succinyl-CoA synthetase, and mitoferrin-1. Multiple studies have suggested the existence of an oligomeric complex that enables ... 269 (1): 390-5. PMID 8276824. Wang X, Poh-Fitzpatrick M, Carriero D, Ostasiewicz L, Chen T, Taketani S, Piomelli S (April 1993 ... 89 (1): 281-5. doi:10.1073/pnas.89.1.281. PMC 48220. PMID 1729699. Lamoril J, Boulechfar S, de Verneuil H, Grandchamp B, ... 378 (5): 1074-1083. doi:10.1016/j.jmb.2008.03.040. PMC 2852141. PMID 18423489. Bencze, Krisztina Z.; Yoon, Taejin; Mill?n- ...
The Effect of Chemicals on Hepatic Heme Biosynthesis | SpringerLink
V. Mechanism of regulation by hemin of the level of δ-aminolevulinate synthetase in rat liver mitochondria. Arch. Biochem. ... Tomita, Y., Ohashi, A., Kikuchi, G.: Induction of δ-aminolevulinate synthetase in organ culture of chick embryo liver by ... Multiple molecular forms of δ-aminolevulinate synthetase in the cytosol and mitochondria of induced cock liver. Arch. Biochem. ... Hayashi, N., Kurashima, Y., Kikuchi, G.: Mechanism of allylisopropylacetamide-induced increase of δ-aminolevulinate synthetase ...
List of MeSH codes (D08) - Wikipedia
... amino acyl-trna synthetases MeSH D08.811.464.263.200.050 - alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ... atp synthetase complexes MeSH D08.811.913.696.650.150.500 - proton-translocating atpases MeSH D08.811.913.696.650.150.500.249 ... fatty acid synthetase complex MeSH D08.811.600.391 - glycine decarboxylase complex MeSH D08.811.600.391.100 - ... uroporphyrinogen iii synthetase MeSH D08.811.520.241.700 - polysaccharide-lyases MeSH D08.811.520.241.700.350 - chondroitinases ...
Nuclear Respiratory Factor 1 | Profiles RNS
Zeitschrift für Naturforschung C
Chlorophyll Biosynthesis: Various Chlorophyllides as Exogenous Substrates for Chlorophyll Synthetase. Benz, Jürgen / Rüdiger, ... 5-year IMPACT FACTOR: 0.912. CiteScore 2017: 0.92. SCImago Journal Rank (SJR) 2017: 0.288. Source Normalized Impact per Paper ( ... Darstellung 5′.5″-phosphatverknüpfter Dinucleoside / Preparation of 5′,5″-Phosphate Linked Dinucleosides. Bomemann, Siegmar / ... An Evolutionary Tree Based on Monoclonal Antibody-Recognized Surface Features of a Plastid Enzyme (5-Aminolevulinate ...
"Differential effects of metalloporphyrins on messenger RNA levels of d" by Edward Earl Cable, Joyce A. Pepe et al.
Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies ... "Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies ... 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Heme Oxygenase (Decyclizing); Liver; Metalloporphyrins; ...
"Effects of mifepristone (RU-486) on heme metabolism and cytochromes P-" by Edward Earl Cable, Joyce A. Pepe et al.
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. - PubMed - NCBI
Find Research outputs
- UTMB Health Research Expert Profiles
Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing ... 5, p. 1546-1558 13 p.. Research output: Contribution to journal › Article › peer-review ... 309-313 5 p.. Research output: Contribution to journal › Article › peer-review ... 391-395 5 p.. Research output: Contribution to journal › Article › peer-review ...
Aberration of heme and hemoprotein in aged female rats - Fingerprint
- Dasman Diabetes Institute Research Portal
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- UTMB Health Research Expert Profiles
Rajagopal, K. & DeAnda, A., May 2020, In: Journal of Thoracic and Cardiovascular Surgery. 159, 5, p. 1704-1705 2 p.. Research ... Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing ... 5, p. 1244-1250 7 p., A026.. Research output: Contribution to journal › Article › peer-review ... 5, p. 829-835 7 p.. Research output: Contribution to journal › Article › peer-review ...
Blood Lead Levels, ALAD Gene Polymorphisms, and Mortality - PubMed
Association between δ-aminolevulinate dehydratase G177C polymorphism and blood lead levels in brain tumor patients. Taha MM, ... Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden. Wetmur JG. Wetmur JG. Environ ... 2015 Sep;3(5):995-1000. doi: 10.3892/mco.2015.589. Epub 2015 Jun 25. Mol Clin Oncol. 2015. PMID: 26623039 Free PMC article. ... 5 μg/dL). We also tested whether the ALAD genotype modified the relationship between blood lead level and mortality. ...
DeCS
Synthetase, delta-Aminolevulinic Acid delta Aminolevulinate Synthase delta Aminolevulinic Acid Synthetase delta-Aminolevulinate ... delta Aminolevulinic Acid Synthetase. delta-Aminolevulinate Synthase. delta-Aminolevulinic Acid Synthetase. Tree number(s):. ... Synthetase, Aminolevulinic Acid. Synthetase, delta-Aminolevulinic Acid. delta Aminolevulinate Synthase. ... Acid Synthetase, Aminolevulinic Acid Synthetase, delta-Aminolevulinic Aminolevulinic Acid Synthetase Synthase, 5- ...
'Glucose effect' and rate limiting function of uroporphyrinogen synthase on porphyrin metabolism in hepatocyte culture:...
Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. Effects of ... The glucose effect in rat liver: studies of delta-aminolevulinate synthase and tyrosine aminotransferase. ... cAMP-dependent induction of delta-aminolevulinate synthase in isolated embryonic chick liver cells. ... The effect of carbohydrate on delta-aminolaevulinate synthetase: the role of ribonucleic acid. ...
Search | Global Index Medicus
Actually there are two isozymes of ALAS and ALAS2 (erythroid delta-aminolevulinate synthase), they play the leading role in the ... Progesterone, its A/B cis reduction and delta aminolevulinic acid synthetase in the developing hen ... It was thought that delta-aminolevulinate synthase (ALAS) is the rate-limiting enzyme in the heme biosynthetic pathway. ... Effect of NiCl2, CoCl2 & cycloheximide on microsomal drug metabolism & ALA-synthetase during thiodemeton toxicity. ...
Draft genome sequence of Streptomyces hyaluromycini MB-PO13T, a hyaluromycin producer | Standards in Genomic Sciences | Full...
amide synthetase. hypothetical protein, partial, Streptomyces sp. NRRL WC-3742, WP_078910860 ... BiosynthesisC5NPolyketide synthaseRubromycin Streptomyces Introduction. Hyaluromycin is a hyaluronidase inhibitor isolated from ... 5]. The strain grow well on ISP 3, ISP 4 and yeast-starch agars but poor on ISP 2, ISP 5, ISP 6, ISP 7, glucose-asparagine, ... The detected menaquinones were identified as MK-9(H8), MK-9(H6), MK-9(H4) and MK-9(H10) (5:37:57:1). The principal polar lipids ...
IMSEAR at SEARO: Search
Search | Global Index Medicus
Identification of genes for growth with oxygen in Escherichia coli by operon fusion and southern blot techniques<...
The hemB encodes 5-aminolevulinate dehydratase or porphobilinogen synthase. The OS3 mutant had insertion in cydB at min 16.6. ... The hemB encodes 5-aminolevulinate dehydratase or porphobilinogen synthase. The OS3 mutant had insertion in cydB at min 16.6. ... The hemB encodes 5-aminolevulinate dehydratase or porphobilinogen synthase. The OS3 mutant had insertion in cydB at min 16.6. ... The hemB encodes 5-aminolevulinate dehydratase or porphobilinogen synthase. The OS3 mutant had insertion in cydB at min 16.6. ...
anti-ALAS1 Primary Antibodies
... delta-ALA synthetase , aminolevulinate, delta, synthase 1 , delta-ALA synthetase 1 , ALA-synthase , aminolevulinate, delta-, ... anti-Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 Antikörper * anti-Aminoacyl tRNA Synthetase ... delta-aminolevulinate synthase 1 , migration-inducing protein 4 , aminolevulinate synthase H , succinyl-CoA: glycine C-succinyl ... Show all anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) Antikörper with Pubmed References. * Human Polyclonal ALAS1 Primary ...
The American Porphyria Foundation | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
The rhizome of Reclinomonas americana, Homo sapiens, Pediculus humanus and Saccharomyces cerevisiae mitochondria | Biology...
2010, 5: e9181-10.1371/journal.pone.0009181.PubMedPubMed CentralView ArticleGoogle Scholar. ... 2004, 5: 123-135. 10.1038/nrg1271.View ArticleGoogle Scholar. *. Minorsky PV: The hot and the classic. Plant Physiol. 2003, 132 ... 10.1016/S1055-7903(03)00194-5.PubMedView ArticleGoogle Scholar. *. Timmis JN, Ayliffe MA, Huang CY, Martin W: Endosymbiotic ... 10.1016/S0168-9525(00)02209-5.PubMedView ArticleGoogle Scholar. *. Martin W: Mosaic bacterial chromosomes - a challenge en ...
The genetic basis of heart disease - wikidoc
Delta-aminolevulinate dehydratase deficiency porphyria see ALA dehydratase deficiency Dementia see CADASIL ... Heme synthetase deficiency see erythropoietic protoporphyria Hemochromatoses see hemochromatosis hemochromatosis hemoglobin M ... Erythroid 5-aminolevulinate synthetase deficiency see X-linked sideroblastic anemia Erythropoietic porphyria see congenital ... 5-ALA dehydratase-deficient porphyria see ALA dehydratase deficiency 5-aminolaevulinic dehydratase deficiency porphyria see ALA ...
GLYCINE | SelfDecode | Genome Analysis
Glutathione synthetase. Glycine amidinotransferase, mitochondrial. Serine--pyruvate aminotransferase. Serine ... The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the bodys production of DNA, phospholipids and ... The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the bodys production of DNA, phospholipids and ... 5-aminolevulinate synthase, nonspecific, mitochondrial. Glycine receptor subunit alpha-1. Glycine receptor subunit alpha-2. ...
European Porphyria Network | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
IMP: Integrative Multi-species Prediction
Synthase15
- Some α-Proteobacteria, fungi, and animals form ALA through condensation of glycine and succinyl-CoA by hemA -encoded aminolevulinate synthase in so called C4 or Shemin pathway. (frontiersin.org)
- Recently, it has been shown that formation of the C 5 N unit and its attachment to core structures of antibiotics is directed by three enzymes: cyclizing 5-aminolevulinate synthase (cALAS encoded by a hemA homolog), amide synthase (AMS) and aminolevulinate-CoA ligase (ALL). (frontiersin.org)
- Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. (umassmed.edu)
- We show that the rate-limiting enzyme in hepatic heme biosynthesis, 5-aminolevulinate synthase (ALAS-1), is regulated by the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha). (nih.gov)
- At the end of eleventh week, gene expression of 5-aminolevulinate synthase (ALAS), ferrochelatase, alpha-globin and beta-globin in bone marrow were measured with RT-PCR. (bvsalud.org)
- The hemB encodes 5-aminolevulinate dehydratase or porphobilinogen synthase. (elsevier.com)
- Auf www.antikoerper-online.de finden Sie aktuell 79 Aminolevulinate, delta-, Synthase 1 (ALAS1) Antikörper von 20 unterschiedlichen Herstellern. (antikoerper-online.de)
- Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. (antikoerper-online.de)
- 5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis. (harvard.edu)
- Anti-Correlation between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase. (harvard.edu)
- Molecular dynamics analysis of the structural and dynamic properties of the functionally enhanced hepta-variant of mouse 5-aminolevulinate synthase. (harvard.edu)
- Regulation of haem biosynthesis in normoblastic erythropoiesis: role of 5-aminolaevulinic acid synthase and ferrochelatase. (naver.com)
- XLSA is caused by mutations in the erythroid-specific gene coding 5-aminolevulinate synthase (ALAS2). (cdc.gov)
- Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are inborn errors of heme biosynthesis with the same phenotype but resulting from autosomal recessive loss-of-function mutations in the ferrochelatase ( FECH ) gene and gain-of-function mutations in the X-linked erythroid-specific 5-aminolevulinate synthase ( ALAS2 ) gene, respectively. (springer.com)
- An important gene associated with Anemia, Sideroblastic, 1 is ALAS2 (5'-Aminolevulinate Synthase 2), and among its related pathways/superpathways are Metabolism and Porphyrin and chlorophyll metabolism . (malacards.org)
Alas21
- ALAS2 is a specific erythroid isoform of 5-aminolevulinate synthetase (ALAS) and is essential for synthesis of hemoglobin in erythroid cells. (spaceshipsla.com)
Biosynthesis4
- Indicate which statement is true of tetrapyrrole biosynthesis in both animals and plants: A) δ -aminolevulinate is a tetrapyrrole precursor. (foodelphi.com)
- Which statement about the carbamoyl phosphate synthetase of mammals, which is used for pyrmidine biosynthesis, is true? (foodelphi.com)
- Distribution of the two pathways of 5-aminolevulinic acid biosynthesis in prokaryotes. (asmscience.org)
- 1988. Biosynthesis of δ-aminolevulinate in greening barley leaves. (asmscience.org)
Erythroid-specific1
- Transfection experiments showed that both Stat1α and Stat3 inhibited the induction by EPO of γ-globin and erythroid-specific 5-aminolevulinate synthetase transcripts, resulting in a reduction of the percentage of hemoglobin-positive cells. (ashpublications.org)
Acyl-CoA synthetase1
- acyl-CoA synthetase long-chain family mem. (broadinstitute.org)
Enzyme1
- An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. (bvsalud.org)
Glycine2
- The average adult ingests 3 to 5 grams of glycine daily. (selfdecode.com)
- 5-aminolevulinate from glycine: step 1/1. (abcam.com)
Deficiency3
- REVIEW: mechanisms involving ALAS deficiency, point mutations, post translational processing, and complex formation with succinyl CoA synthetase subunit B in the pathogenesis of hereditary sideroblastic anemia. (antikoerper-online.de)
- 5. In Anglo-Saxon populations, neural tube defects, ranging from spina bifida to anencephaly (including hydrocephalus) are the most prevalent types of cerebral deficiency. (fondationlejeune.org)
- [5] Additionally, patients will often void a wine-red color urine with an increased concentration of uroporphyrin I due to their enzymatic deficiency. (wikipedia.org)
ALAS1
- Unlike "classical" primary metabolism ALAS, the C 5 N unit-forming c yclizing ALAS (cALAS) catalyses intramolecular cyclization of nascent 5-aminolevulinate. (frontiersin.org)
Genes3
- A combined approach, comprising PCR screening and genome mining, was used to unravel the diversity and phylogeny of genes encoding 5-aminolevulinic acid synthases (ALASs, hemA gene products) in streptomycetes-related strains. (frontiersin.org)
- In actinomycetes, these genes were believed to be directly connected with the production of secondary metabolites carrying the C 5 N unit, 2-amino-3-hydroxycyclopent-2-enone, with biological activities making them attractive for future use in medicine and agriculture. (frontiersin.org)
- First, we identified the genes that were differentially expressed in GBMs (3 datasets) compared to non-GBM brain tissues (5 datasets), or were associated with survival differences. (beds.ac.uk)
Porphyria1
- Blum, I., Schoenfeld, N., Atsmon, A.: The effect of DL-propranolol on δ-aminolevulinic acid synthetase activity and urinary excretion of porphyrins in allylisopropylacetamide-induced experimental porphyria. (springer.com)
ALAD2
- The 5-aminolevulinic acid dehydratase (ALAD) G177C genetic polymorphism (rs 1800435) affects lead toxicokinetics and may alter the adverse effects of lead exposure. (cdc.gov)
- Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead. (cdc.gov)
Glutamine synthetase1
- A glutamine synthetase inhibitor, MSX, stimulated ammonium excretion and H 2 -production and pulses of MSX rather than a single dose favoured both the processes. (go.jp)
Porphyrin2
- Methyl aminolevulinate cream is a porphyrin precursor used in combination with narrow-band, red-light illumination for nonhyperkeratotic, nonpigmented actinic keratoses. (medscape.com)
- Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS. (curehunter.com)
Precursor2
- 5-aminolevulinate (ALA) is a key precursor of a huge family of essential tetrapyrrole compounds. (frontiersin.org)
- The biosynthetic steps from the earliest universal precursor, 5-aminolevulinic acid (ALA), to protoporphyrin IX-based hemes constitute the major, common portion of the pathway, and other steps leading to specific groups of products can be considered branches off the main axis. (asmscience.org)
Tyrosine1
- 1 The binding of EPO to its specific receptor on the cell surface induces tyrosine phosphorylation and the activation of several proteins, including Janus kinase 2 (JAK2), 2 signal transducer and activator of transcription 5 (Stat5), 3-5 mitogen-associated protein kinases, 6 and phospholipase C-γ1. (ashpublications.org)
Liver4
- Edwards, A.M., Elliott, W.H.: Induction of δ-aminolevulinic acid synthetase in isolated rat liver cell suspensions. (springer.com)
- Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. (meta.org)
- Salonpää P, Iscan M, Pasanen M, Arvela P, Pelkonen O, Raunio H. Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice. (labome.org)
- These data indicate that the Cyp2a-4/5 complex is regulated in a different way in DBA/2 and C57BL/6 mice and that some association exists between the development of liver damage and COH induction. (labome.org)
Adenosine1
- Adenosine 3′:5′-monophosphate dependence of induction by drugs. (springer.com)
Cytochrome2
- A transcription factor that controls the expression of variety of proteins including CYTOCHROME C and 5-AMINOLEVULINATE SYNTHETASE. (umassmed.edu)
- The delta-aminolevulinic acid synthetase activity and the effect of exogenous delta-aminolevulinate on the synthesis of cytochrome c in the thoracic muscles of the tobacco horn worm during adult development. (pianolarge.ml)
Glutathione1
- GSS (glutathione synthetase) was not differentially expressed, but higher levels were linked to poor progression free survival. (beds.ac.uk)
Exonuclease1
- C) It contains a 3′ to 5′ exonuclease activity. (foodelphi.com)
Acid3
- It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and inhibiting thymidylate synthetase and, subsequently, cell proliferation. (medscape.com)
- 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. (drugbank.ca)
- 86. Method for monitoring a risk of an individual to become obese comprising a step of measuring the urinary excretion of a Krebs cycle metabolite dependent on SUCLA2 gene activity, wherein the metabolite of the SUCLA2 gene is urinary methylmalonic acid, succinate (succinic acid), fumarate (fumaric acid) or succinyl-CoA synthetase activity. (patentsencyclopedia.com)
Acute1
- Total 14 patients had acute myeloid leukemia, 10 had acute lymphoblastic leukemia, 5 had myelodysplastic syndrome, 3 had non-Hodgkin's lymphoma, and 2 had aplastic anemia. (bvsalud.org)
Biosynthetic2
- We consider the presence of this gene triad to be a specific genetic marker of the C 5 N unit biosynthetic pathway that "tags" producers of C 5 N-containing metabolites among others. (frontiersin.org)
- The principal aim of our work was to show the potential of the hemA -targeted genetic screening in identification of novel putative biosynthetic gene clusters encoding C 5 N-containing metabolites. (frontiersin.org)
Molecules1
- D) A total of 4 δ-aminolevulinate molecules are used to synthesize 1 heme molecule. (foodelphi.com)
Excretion1
- A higher dose (15μM) in comparison to lower dose (5μM) of MSX, although it stimulated H 2 -evolution and NH 4 + -excretion, shortened the duration of both the processes. (go.jp)
Gene expression1
- 1 In addition to these well-established functions as a prosthetic group, recent reports have revealed that heme regulates several transcription factors, including Bach1, 2 ⇓ ⇓ - 5 NPAS2, 6 and REV-ERBs, 7 and modulates gene expression as an inter- and intracellular signaling molecule in mammals. (bloodjournal.org)
Proceedings1
- Research Proceedings 5: 29, 1957.3. (spaceshipsla.com)