5-Aminolevulinate Synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Aminolevulinic Acid
Porphobilinogen Synthase
Anemia, Sideroblastic
Glutamate-Ammonia Ligase
Amino Acyl-tRNA Synthetases
2',5'-Oligoadenylate Synthetase
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
Hydroxymethylbilane Synthase
An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen (UROPORPHYRINOGENS) in several discrete steps. It is the third enzyme in the 8-enzyme biosynthetic pathway of HEME. In humans, deficiency in this enzyme encoded by HMBS (or PBGD) gene results in a form of neurological porphyria (PORPHYRIA, ACUTE INTERMITTENT). This enzyme was formerly listed as EC 4.3.1.8
Boranes
Hemin
Allylisopropylacetamide
Dicarbethoxydihydrocollidine
Rhodobacter capsulatus
Heme
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genetic Diseases, X-Linked
Peptide Synthases
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Schiff Bases
Ferrochelatase
Base Sequence
Intramolecular Transferases
Amino Acid Sequence
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Pyridoxal
Ligases
Erythroblasts
Aspartate-tRNA Ligase
Methionine-tRNA Ligase
Tryptophan-tRNA Ligase
Iron-Regulatory Proteins
Carbon-Nitrogen Ligases
Protoporphyrins
Isoleucine-tRNA Ligase
Aspartate-Ammonia Ligase
Glycine
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Pyridoxine
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Phenylalanine-tRNA Ligase
Photochemotherapy
Spectrophotometry
Carbamoyl-Phosphate Synthase (Ammonia)
Circular Dichroism
Cloning, Molecular
Argininosuccinate Synthase
Acetate-CoA Ligase
Enzyme Induction
delta-Aminolevulinate synthetases in the liver cytosol fraction and mitochondria of mice treated with allylisopropylacetamide and 3,5-dicarbethoxyl-1,4-dihydrocollidine. (1/369)
Hepatic delta-aminolevulinate (ALA) synthetase was induced in mice by the administration of allylisopropylacetamide (AIA) and 3,5-dicarbethoxy-1,4-dihydrocollidine (DDC). In both cases, a significant amount of ALA synthetase accumulated in the liver cytosol fraction as well as in the mitochondria. The apparent molecular weight of the cytosol ALA synthetase was estimated to be 320,000 by gel filtration, but when the cytosol ALA synthetase was subjected to sucrose density gradient centrifugation, it showed a molecular weight of 110,000. In the mitochondria, there were two different sizes of ALA synthetase with molecular weights of 150,000 and 110,000, respectively; the larger enzyme was predominant in DDC-treated mice, whereas in AIA-treated mice and normal mice the enzyme existed mostly in the smaller form. When hemin was injected into mice pretreated with DDC, the molecular size of the mitochondrial ALA synthetase changed from 150,000 to 110,000. The half-life of ALA synthetase in the liver cytosol fraction was about 30 min in both the AIA-treated and DDC-treated mice. The half-life of the mitochondrial ALA synthetase in AIA-treated mice and normal mice was about 60 min, but in DDC-treated mice the half-life was as long as 150 min. The data suggest that the cytosol ALA synthetase of mouse liver is a protein complex with properties very similar to those of the cytosol ALA synthetase of rat liver, which has been shown to be composed of the enzyme active protein and two catalytically inactive binding proteins, and that ALA synthetase may be transferred from the liver cytosol fraction to the mitochondria with a size of about 150,000 daltons, followed by its conversion to enzyme with a molecular weight of 110,000 within the mitochondria. The process of intramitochondrial enzyme degradation seems to be affected in DDC-treated animals. (+info)Four new mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causing X-linked sideroblastic anemia: increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary hemochromatosis. (2/369)
X-linked sideroblastic anemia (XLSA) in four unrelated male probands was caused by missense mutations in the erythroid-specific 5-aminolevulinate synthase gene (ALAS2). All were new mutations: T647C, C1283T, G1395A, and C1406T predicting amino acid substitutions Y199H, R411C, R448Q, and R452C. All probands were clinically pyridoxine-responsive. The mutation Y199H was shown to be the first de novo XLSA mutation and occurred in a gamete of the proband's maternal grandfather. There was a significantly higher frequency of coinheritance of the hereditary hemochromatosis (HH) HFE mutant allele C282Y in 18 unrelated XLSA hemizygotes than found in the normal population, indicating a role for coinheritance of HFE alleles in the expression of this disorder. One proband (Y199H) with severe and early iron loading coinherited HH as a C282Y homozygote. The clinical and hematologic histories of two XLSA probands suggest that iron overload suppresses pyridoxine responsiveness. Notably, reversal of the iron overload in the Y199H proband by phlebotomy resulted in higher hemoglobin concentrations during pyridoxine supplementation. The proband with the R452C mutation was symptom-free on occasional phlebotomy and daily pyridoxine. These studies indicate the value of combined phlebotomy and pyridoxine supplementation in the management of XLSA probands in order to prevent a downward spiral of iron toxicity and refractory anemia. (+info)Properties of 5-aminolaevulinate synthetase and its relationship to microsomal mixed-function oxidation in the southern armyworm (Spodoptera eridania). (3/369)
1. Activity of 5-aminolaevulinate synthetase was measured in the midgut and other tissues of the last larval instar of the southern armyworm (Spodoptera eridania Cramer, formerly Prodenia eridania Cramer). 2. Optimum conditions for measuring the activity were established with respect to all variables involved and considerable differences from those reported for mammalian enzyme preparations were found. 3. Maximum activity (20 nmol/h per mg of protein) occurs 18-24 h after the fifth moult and thereafter decreases to trace amounts as the larvae age and approach pupation. 4. Synthetase activity was rapidly induced by oral administration (in the diet) of pentamethylbenzene, phenobarbital, diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3, 5-dicarboxylate, and 2-allyl-2-isopropylacetamide. 5. Puromycin inhibited the induction of synthetase by pentamethylbenzene. 6. Induction of 5-aminolaevulinate synthetase correlated well with the induction of microsomal N-demethylation of p-chloro-N-methylaniline, except for phenobarbital, which induced the microsomal oxidase relatively more than the synthetase. (+info)Pre-steady-state reaction of 5-aminolevulinate synthase. Evidence for a rate-determining product release. (4/369)
5-Aminolevulinate synthase (ALAS) is the first enzyme of the heme biosynthetic pathway in non-plant eukaryotes and the alpha-subclass of purple bacteria. The pyridoxal 5'-phosphate cofactor at the active site undergoes changes in absorptive properties during substrate binding and catalysis that have allowed us to study the kinetics of these reactions spectroscopically. Rapid scanning stopped-flow experiments of murine erythroid 5-aminolevulinate synthase demonstrate that reaction with glycine plus succinyl-CoA results in a pre-steady-state burst of quinonoid intermediate formation. Thus, a step following binding of substrates and initial quinonoid intermediate formation is rate-determining. The steady-state spectrum of the enzyme is similar to that formed in the presence of 5-aminolevulinate, suggesting that release of this product limits the overall rate. Reaction of either glycine or 5-aminolevulinate with ALAS is slow (kf = 0.15 s-1) and approximates kcat. The rate constant for reaction with glycine is increased at least 90-fold in the presence of succinyl-CoA and most likely represents a slow conformational change of the enzyme that is accelerated by succinyl-CoA. The slow rate of reaction of 5-aminolevulinate with ALAS is 5-aminolevulinate-independent, suggesting that it also represents a slow isomerization of the enzyme. Reaction of succinyl-CoA with the enzyme-glycine complex to form a quinonoid intermediate is a biphasic process and may be irreversible. Taken together, the data suggest that turnover is limited by release of 5-aminolevulinate or a conformational change associated with 5-aminolevulinate release. (+info)Phylogenetic analysis of the 5-aminolevulinate synthase gene. (5/369)
The evolution of 5-aminolevulinate synthase (ALS) was studied by acquiring sequence data and generating phylogenetic trees. Gene sequences were already available for a variety of vertebrates (which have both a housekeeping and an erythroid form of the gene), fungi, alpha-proteobacteria, and one protist and one protostome. In order to generate representative trees, ALS sequence data were acquired from various deuterostomes and protostomes. The species and tissues selected for study were beluga whale liver, hagfish blood, sea urchin gonadal tissue, cuttlefish hepatopancreas, horseshoe crab hepatopancreas, and bloodworm blood. The new sequences and those previously published were examined for the presence of heme-regulatory motifs (HRMs) and iron-responsive elements (IREs). The HRMs are present in almost all eukaryotic species, which suggests their fundamental role in the regulation of ALS. The IREs are present in all vertebrate erythroid forms of ALS, which indicates that in those animals, expression of the erythroid form of the enzyme and, hence, hemoglobin production can be influenced by the intracellular content of iron. The new sequences were aligned with previously reported ALS sequences, and phylogenetic analyses were performed. The resulting trees provided evidence regarding the timing of the gene duplication event that led to the two forms of the ALS gene in vertebrates. It appears that the housekeeping and erythroid forms of ALS probably arose before the divergence of hagfish from the deuterostome line leading to the vertebrates. The data also add to the evidence indicating that alpha-proteobacteria are the nearest contemporary relatives of mitochondria. (+info)Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells. (6/369)
Nuclear respiratory factor (NRF)-1 appears to be important for the expression of several respiratory genes, but there is no direct evidence that NRF-1 transduces a physiological signal into the production of an enzyme critical for mitochondrial biogenesis. We generated HeLa cells containing plasmids allowing doxycycline-inducible expression of uncoupling protein (UCP)-1. In the absence of doxycycline, UCP-1 mRNA and protein were undetectable. In the presence of doxycycline, UCP-1 was expressed and oxygen consumption doubled. This rise in oxygen consumption was associated with an increase in NRF-1 mRNA. It was also associated with an increase in NRF-1 protein binding activity as determined by electrophoretic mobility shift assay using a functional NRF-1 binding site from the delta-aminolevulinate (ALA) synthase promoter. Respiratory uncoupling also caused a time-dependent increase in protein levels of ALA synthase, an early marker for mitochondrial biogenesis. ALA synthase induction by respiratory uncoupling was prevented by transfecting cells with an oligonucleotide antisense to the region of the NRF-1 initiation codon; a scrambled oligonucleotide with the same base composition had no effect. Respiratory uncoupling increases oxygen consumption and lowers energy reserves. In HeLa cells, uncoupling also increases ALA synthase, an enzyme critical for mitochondrial respiration, but only if translatable mRNA for NRF-1 is available. These data suggest that the transcription factor NRF-1 plays a key role in cellular adaptation to energy demands by translating physiological signals into an increased capacity for generating energy. (+info)Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli. (7/369)
The hemA and hemT genes encoding 5-aminolaevulinic acid synthase (ALAS) from the photosynthetic bacterium Rhodobacter sphaeroides, were cloned to allow high expression in Escherichia coli. Both HemA and HemT appeared to be active in vivo as plasmids carrying the respective genes complemented an E. coli hemA strain (glutamyl-tRNA reductase deficient). The over-expressed isoenzymes were isolated and purified to homogeneity. Isolated HemA was soluble and catalytically active whereas HemT was largely insoluble and failed to show any activity ex vivo. Pure HemA was recovered in yields of 5-7 mg x L-1 of starting bacterial culture and pure HemT at 10 mg x L-1 x HemA has a final specific activity of 13 U x mg-1 with 1 unit defined as 1 micromol of 5-aminolaevulinic acid formed per hour at 37 degrees C. The Km values for HemA are 1.9 mM for glycine and 17 microM for succinyl-CoA, with the enzyme showing a turnover number of 430 h-1. In common with other ALASs the recombinant R. sphaeroides HemA requires pyridoxal 5'-phosphate (PLP) as a cofactor for catalysis. Removal of this cofactor resulted in inactive apo-ALAS. Similarly, reduction of the HemA-PLP complex using sodium borohydride led to > 90% inactivation of the enzyme. Ultraviolet-visible spectroscopy with HemA suggested the presence of an aldimine linkage between the enzyme and pyridoxal 5'-phosphate that was not observed when HemT was incubated with the cofactor. HemA was found to be sensitive to reagents that modify histidine, arginine and cysteine amino acid residues and the enzyme was also highly sensitive to tryptic cleavage between Arg151 and Ser152 in the presence or absence of PLP and substrates. Antibodies were raised to both HemA and HemT but the respective antisera were not only found to bind both enzymes but also to cross-react with mouse ALAS, indicating that all of the proteins have conserved epitopes. (+info)A photosensitising adenovirus for photodynamic therapy. (8/369)
We have developed a new approach to photodynamic therapy based on adenoviral transduction of the rate-limiting enzyme in heme synthesis. Conventional phototherapy uses porphyrin-based chemical photosensitisers, including delta-aminolaevulinic acid (ALA) which is converted to protoporphyrin IX (PpIX) by the enzymes of the heme biosynthetic pathway. The lack of a specific mechanism for targeting chemical photosensitisers and PpIX to tumour cells means that therapeutic irradiation can damage normal tissue and exposure to sunlight following treatment can cause severe burns. The rate limiting enzyme in PpIX synthesis is ALA-synthase (ALA-S). We have developed a new yeast vector system for manipulation of the adeno- virus genome and used it to construct a virus expressing a mutant form of ALA-S lacking the iron response elements which regulate ALA-S translation and the heme regulatory motifs which regulate import of ALA-S into mitochondria. The virus induces a large increase in PpIX expression and confers photosensitivity on cultured cells. Unlike conventional photodynamic therapy, a viral approach makes it possible to restrict photosensitivity by biological rather than purely physical or chemical means. As with HSV thymidine kinase, ALA-S expression is a general mechanism for sensitisation to a therapeutic agent which can easily be adapted to whatever means of gene delivery is most effective. (+info)
Effect of endotoxin on tryptophan pyrrolase and delta-aminolaevulinate synthase: evidence for an endogenous regulatory haem...
Induction of hepatic δ-aminolevulinate synthase and cytochrome P-450 by a thiazide diuretic<...
Methyl aminolevulinate photodynamic therapy | DermNet NZ
Methyl Aminolevulinate Topical - Side Effects, Dosage, Interactions - Drugs - Everyday Health
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ALAS-2019-1310
XLSA - X-Linked Sideroblastic Anemia | AcronymFinder
Congenital Sideroblastic Anemia | Boston Childrens Hospital
Pyridoxine-responsive primary acquired sideroblastic anaemia : in vitro and in vivo effects of vitamin B6 on decreased 5...
Aminolevulinic acid synthase - Wikipedia
Iron loading of cultured hepatocytes. Effect of iron on 5-aminolaevulinate synthase is independent of lipid peroxidation |...
An infant with Pearson syndrome: a rare cause of congenital sideroblastic anemia and bone marrow failure | Blood Journal
sideroblastic anemia
Best Sideroblastic Anemia Doctor in Kolkata, Sideroblastic Anemia Doctors | Credihealth
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses,...
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Long-term sucrose and glucose consumption decreases the δ-aminolevulinate dehydratase activity in mice
August 2017 - Small-Molecule Inhibitors of Protein Interactions
Sideroblastic Anemias - Hematology and Oncology - Merck Manuals Professional Edition
ANEMIA, SIDEROBLASTIC, 3, PYRIDOXINE-REFRACTORY; SIDBA3 | MENDELIAN.CO
Erythropoietic porphyria - Wikipedia
The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic...
Idiopathic sideroblastic anemia | definition of idiopathic sideroblastic anemia by Medical dictionary
Sideroblastic Anemia. Basic Information, Causes, Diagnosis and Treatment of Sideroblastic Anemia
ALAS2 gene - Genetics Home Reference - NIH
Hereditary sideroblastic anemia
Comparative study of effect of inorganic lead and cadmium on blood δ-aminolevulinate dehydratase in man | Occupational &...
Gene Responsible For A Rare Form Of Congenital Anemia Identified
JCI -
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia
Anemia, sideroblastic, pyridoxine-refractory autosomal recessive | definition of anemia, sideroblastic, pyridoxine-refractory...
ICD-10 Diagnosis Code D64.0 Hereditary sideroblastic anemia
SACOL RS12725 - AureoWiki
Anemia, Sideroblastic | 5-Minute Clinical Consult
Youbet, Betandwin, Admiral, Sportingbet - Beiträge pro Seite
Sideroblastic anemia -...
Pearson syndrome in an infant heterozygous for C282Y allele of HFE gene.
FA Biochemistry Heme Synthesis Flashcards - Cram.com
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to...
Eldorado: Δ-Aminolevulinate dehydratase and glutathione peroxidase activity in Alzheimers disease
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British Library EThOS: Structure and function of tetrapyrrole biosynthesis enzymes: ALA synthase and cobalt chelatase
Sideroblastic Anemia
Macrocytic Anemia in Manifesting Females<...
Subcellular Localization of Iron and Heme Metabolism Related Proteins at Early Stages of Erythrophagocytosis - pdf descargar
HS Codes - Taiwan vi 28.13.90 - Commerical phosphorus trisulphide
Human ALAD adenoviral particles Shirley - Science Marketplace
Refdoc
Reactome | Heme biosynthesis
길랑 바레 증후군으로 오인된 중증의 감각운동 다발성 신경병증 환자에서 급성 간헐 포르피린증 선별의 중요성: 증례 보고
Plus it
Determination of delta-aminolevulinic acid in blood plasma and urine by gas-liquid chromatography. - Semantic Scholar
Differential effects of mitomycin C on constitutive and inducible gene expression in the chick embryo liver in vivo:...
Primary acquired sideroblastic erythropoiesis in non-anaemic and minimally anaemic subjects. | Journal of Clinical Pathology
THE DYSPLASTIC AND SIDEROBLASTIC ANEMIAS | Hematology in Clinical Practice, 5e | AccessHemOnc | McGraw-Hill Medical
THE DYSPLASTIC AND SIDEROBLASTIC ANEMIAS | Hematology in Clinical Practice, 5e | AccessBiomedical Science | McGraw-Hill Medical
Tiffany PUSH PLAY School Boy Humor | OCEANUP TEEN GOSSIP
Ferrochelatase
... succinyl-CoA synthetase, and mitoferrin-1. Multiple studies have suggested the existence of an oligomeric complex that enables ... 269 (1): 390-5. doi:10.1016/S0021-9258(17)42362-3. PMID 8276824. Wang X, Poh-Fitzpatrick M, Carriero D, Ostasiewicz L, Chen T, ... 89 (1): 281-5. Bibcode:1992PNAS...89..281N. doi:10.1073/pnas.89.1.281. PMC 48220. PMID 1729699. Lamoril J, Boulechfar S, de ... 378 (5): 1074-1083. doi:10.1016/j.jmb.2008.03.040. PMC 2852141. PMID 18423489. Bencze, Krisztina Z.; Yoon, Taejin; Mill?n- ...
List of MeSH codes (D08)
... amino acyl-trna synthetases MeSH D08.811.464.263.200.050 - alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ... atp synthetase complexes MeSH D08.811.913.696.650.150.500 - proton-translocating atpases MeSH D08.811.913.696.650.150.500.249 ... fatty acid synthetase complex MeSH D08.811.600.391 - glycine decarboxylase complex MeSH D08.811.600.391.100 - ... uroporphyrinogen iii synthetase MeSH D08.811.520.241.700 - polysaccharide-lyases MeSH D08.811.520.241.700.350 - chondroitinases ...
SUCLA2
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha ... Succinyl-CoA synthetase SUCLG1 SUCLG2 GRCh38: Ensembl release 89: ENSG00000136143 - Ensembl, May 2017 GRCm38: Ensembl release ... Furuyama K, Sassa S (March 2000). "Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is ... Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2), also known as ADP-forming succinyl-CoA synthetase (SCS- ...
Annimycin
The gene ann1 encode for an ATP-dependent amide synthetase and is predicted to condense the amine of the C5N group with the ... More over module 5 contains a dehydratase (DH) domain that is not functional. Kalan, Lindsay; Gessner, Arne; Thaker, Maulik N ... The ann5 gene product is organized in modules 4 a 5, the latter terminating with a thioesterase domain. One of the most ... The ann2 gene encode for a 5-aminolevulinate synthase which condenses glycine and succinyl-CoA in a Claisen-like reaction to ...
Chromosome 9
... argininosuccinate synthetase BANCR: encoding protein BRAF-activated non-protein coding RNA BNC2: zinc finger protein basonuclin ... aminolevulinate, delta-, dehydratase ALS4: amyotrophic lateral sclerosis 4 ANGPTL2: angiopoietin-related protein 2 ASS: ... 5 (2): 157-74. doi:10.1089/109065701753145664. PMID 11551106. Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and ... 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615. "Statistics & Downloads for chromosome 9". HUGO Gene ...
ALAS2
"Entrez Gene: Delta-aminolevulinate synthase 2". Han L, Zhong Y, Huang B, Han L, Pan L, Xu X, Wang X, Huang B, Lu J (2008). " ... Furuyama K, Sassa S (Mar 2000). "Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is ... Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein that in humans is encoded by the ALAS2 gene. ALAS2 is an ... Bishop DF, Henderson AS, Astrin KH (Jun 1990). "Human delta-aminolevulinate synthase: assignment of the housekeeping gene to ...
Chromosome 3
Partial list of the genes located on p-arm (short arm) of human chromosome 3: ALAS1: aminolevulinate, delta-, synthase 1 APEH: ... leucyl-tRNA synthetase, mitochondrial LIMD1: LIM domain-containing protein 1 LOC105377021: encoding protein LOC105377021 ... 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615. "Statistics & Downloads for chromosome 3". HUGO Gene ... ETS variant 5 FAM3D: family with sequence similarity 3, member D FAM43A: family with sequence similarity 43 member A FAM162A: ...
Porphyria cutanea tarda
Additionally, alcohol has been shown to increase the activity of the delta-aminolevulinic acid synthetase (ALA synthetase), the ... 14 (38): 5913-5. doi:10.3748/wjg.14.5913. PMC 2751904. PMID 18855993. Sökmen, M; Demirsoy, H; Ersoy, O; Gökdemir, G; Akbayir, N ... 18 (3): 200-5. PMID 17891697. Frank, J; Poblete-Gutiérrez, P; Weiskirchen, R; Gressner, O; Merk, H. F.; Lammert, F (2006). " ... 58 (5): 1089-97. doi:10.1172/JCI108560. PMC 333275. PMID 993332. Di Padova, C.; Marchesi, L.; Cainelli, T.; Gori, G.; Podenzani ...
Actinic keratosis
AKs are one of the most common dermatologic lesions for which photodynamic therapy, including topical methyl aminolevulinate ( ... destroys AKs by blocking methylation of thymidylate synthetase, thereby interrupting DNA and RNA synthesis. This in turn ... Topical 5-FU is the most utilized treatment for AK, and often results in effective removal of the lesion. Overall, there is a ... 5-FU may be up to 90% effective in treating non-hyperkeratotic lesions. While topical 5-FU is a widely used and cost-effective ...
List of EC numbers (EC 2)
... aminolevulinate transaminase EC 2.6.1.44: alanine-glyoxylate transaminase EC 2.6.1.45: serine-glyoxylate transaminase EC 2.6. ... glutamine synthetase]-adenylyl-L-tyrosine phosphorylase EC 2.7.7.90: 8-amino-3,8-dideoxy-manno-octulosonate ... glutamine synthetase] adenylyltransferase EC 2.7.7.43: N-acylneuraminate cytidylyltransferase EC 2.7.7.44: glucuronate-1- ... 5-hydroxyanthranilate N-hydroxycinnamoyltransferase (*) EC 2.3.1.303: α-L-Rha-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Gal-PP-Und ...
Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is different from that in liver<...
Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is different from that in liver. / Elferink, C. J.; ... Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is different from that in liver. Journal of Biological ... Elferink, C. J. ; Sassa, S. ; May, B. K. / Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is different ... Elferink, C. J., Sassa, S., & May, B. K. (1988). Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is ...
DeCS
IMSEAR at SEARO: Search
Glycine and Serine metabolism
B6db references : 4624703
Phosphatidylcholine-Sterol O-Acyltransferase | Harvard Catalyst Profiles | Harvard Catalyst
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43 ...
MedlinePlus: Genetic Conditions: E
Early-onset biotin-responsive multiple carboxylase deficiency, see Holocarboxylase synthetase deficiency. *Early-onset combined ... Epiphyseal dysplasia, multiple, 5, see Multiple epiphyseal dysplasia. *Epiphyseal dysplasia, Ribbing type, see Multiple ... Erythroid 5-aminolevulinate synthase deficiency, see X-linked sideroblastic anemia. *Erythrokeratodermia variabilis, see ... carboxylase deficiency, see Holocarboxylase synthetase deficiency. *Early-onset generalized torsion dystonia, see Early-onset ...
ATP Citrate (pro-S)-Lyase | Profiles RNS
Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E. Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity. 2019 12 17; 51(6):997-1011.e7 ...
Acyl-Carrier Protein S-Malonyltransferase | Colorado PROFILES
Jörgen Isgaard - NeL.edu
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
Diacylglycerol O-Acyltransferase | Profiles RNS
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Glycine (YMDB00016) - Yeast Metabolome Database
2. Glutathione synthetase. General function:. Involved in ATP binding. Specific function:. ATP + gamma-L-glutamyl-L-cysteine + ... Glycyl-tRNA synthetase 2. General function:. Involved in nucleotide binding. Specific function:. Catalyzes the attachment of ... 8. Glycyl-tRNA synthetase 1. General function:. Involved in nucleotide binding. Specific function:. Catalyzes the attachment of ... Turner, R. J., Lovato, M., Schimmel, P. (2000). "One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae ...
DESCARTES FETAL INTESTINE ERYTHROBLASTS
DeCS 2010 - February 12, 2010 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3-Hydroxy-3-methylglutaric Acid ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2009 - February 20, 2009 version
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
Model Search | BioModels
Asparagine synthetase [glutamine-hydrolyzing] 1 (4) * Lanosterol 14-alpha demethylase (4) * Imidazole glycerol phosphate ... Putative inosine-5-monophosphate dehydrogenase-like protein YAR075W (2) * Mannosyl phosphorylinositol ceramide synthase SUR1 ( ... Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51 (2) * L-serine dehydratasePutative truncated L-serine dehydratase ... Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (4) * Dolichyl-phosphate-mannose--protein mannosyltransferase 2 (4 ...
HOSHIDA LIVER CANCER SURVIVAL DN
Basal Cell Carcinoma
Methyl aminolevulinate (Metvixia). *Dosing, Interactions, etc.. Clinical Context: Methyl aminolevulinate cream is a porphyrin ... It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and inhibiting thymidylate synthetase and, ... In a study by Puccioni et al, PDT using methyl aminolevulinate showed notable success and appears to be a viable option in the ... Photodynamic therapy using methyl aminolevulinate acid in eyelid basal cell carcinoma: a 5-year follow-up study. Ophthal Plast ...
Basal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Modalities and Guidelines, Topical Treatments
In a study by Puccioni et al, PDT using methyl aminolevulinate showed notable success and appears to be a viable option in the ... It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and inhibiting thymidylate synthetase and, ... Photodynamic therapy using methyl aminolevulinate acid in eyelid basal cell carcinoma: a 5-year follow-up study. Ophthal Plast ... Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for ...
Synthase9
- We have measured the transcriptional gene activity of 5-aminolevulinate synthase, the first enzyme of the heme biosynthetic pathway, together with corresponding mRNA and protein levels in mouse erythroleukemic cells induced to differentiate with dimethyl sulfoxide. (utmb.edu)
- When the heme biosynthetic pathway was blocked by succinylacetone there was a large increase in both 5-aminolevulinate synthase activity and protein levels, and this was reversed by the addition of exogenous hemin. (utmb.edu)
- Transcriptional activity of the 5-aminolevulinate synthase gene and mRNA levels were both significantly increased during differentiation of cells by dimethyl sulfoxide but were not markedly altered by succinylacetone or hemin treatment. (utmb.edu)
- The results demonstrate that levels of 5-aminolevulinate synthase in mouse erythroleukemic cells are regulated by a significant post-transcriptional mechanism possibly at the translational level. (utmb.edu)
- Evidence is also presented for a less significant post-transcriptional control by heme of mRNA levels for 5-aminolevulinate synthase. (utmb.edu)
- These results indicate that the regulation of 5-aminolevulinate synthase in differentiating erythroid cells is complex but differs from that in liver cells where heme controls to level of 5-aminolevulinate synthase by acting primarily to inhibit gene transcription. (utmb.edu)
- Elferink, CJ , Sassa, S & May, BK 1988, ' Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is different from that in liver ', Journal of Biological Chemistry , vol. 263, no. 26, pp. 13012-13016. (utmb.edu)
- 5'-aminolevulinate synthase 1 [Source:HGNC. (gsea-msigdb.org)
- In C4 pathway, 5-ALA is derived from condensation of succinyl-CoA and glycine by 5-aminolevulic acid synthase (ALAS) with pyridoxal phosphate (PLP) as co-factor in one-step biotransformation. (springeropen.com)
Biosynthesis3
- As chemical synthesis of 5-ALA performed low yield, complicated processes, and high cost, biosynthesis of 5-ALA via C4 (also called Shemin pathway) and C5 pathway related to heme biosynthesis in microorganism equipped more advantages. (springeropen.com)
- 5-aminolevulinic acid (5-ALA), an endogenous non-proteinogenic five-carbon amino acid, is the indispensable intermediate which involves in the tetrapyrrole biosynthesis and is the first compound from the porphyrin synthesis to heme. (springeropen.com)
- As a key precursor in the biosynthesis of porphyrins, 5-ALA has been considered to increasing the yield of foliage and root. (springeropen.com)
Enzymes1
- The C5 pathway involves three enzymes comprising glutamyl-tRNA synthetase (GltX), glutamyl-tRNA reductase (HemA), and glutamate-1-semialdehyde aminotransferase (HemL) from α-ketoglutarate in TCA cycle to 5-ALA and heme. (springeropen.com)
Topical2
- Topical 5% imiquimod is approved by the US Food and Drug Administration (FDA) for the treatment of nonfacial superficial BCCs that are less than 2 cm in diameter. (medscape.com)
- On the other hand, therapy with 5-ALA not only possesses potential for topical, rapid and effective application but is also the non-toxic to human body (Wild et al. (springeropen.com)
Protein2
- expressed in middle/late meiosis,IV" YDR525W 1 5 7 YDR525W "Ydr525wp,IV" YDR526C 1 5 8 YDR526C "Ydr526cp,IV" YER187W 1 5 9 YER187W "similar to killer toxin,V" YER188W 1 5 10 YER188W "Yer188wp,V" YER190W 1 5 11 YER190W "Yrf1-2p,V" YFL002C 1 5 12 YFL002C "ATP-dependent RNA helicase,VI" YFL002W-B 1 5 13 YFL002W-B "TyA gag protein. (davidson.edu)
- XIII" YMR047C 3 13 3 YMR047C "Nuclear pore complex protein that is member of GLFG repeat-containing family of nucleoporins and is,XIII" YMR049C 3 13 4 YMR049C "Ymr049cp,XIII" YMR051C 3 13 5 YMR051C "TyA Gag protein. (davidson.edu)
Glycine1
- An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. (bvsalud.org)
Purification1
- The purification process, challenges, and opportunities of 5-ALA for industrial applications are also summarized. (springeropen.com)
Heme1
- 5-ALA as the precursor of heme, chlorophylls, and vitamin B 12 significantly affects the cell growth and metabolic flux. (springeropen.com)
Gene1
- Moreover, isocitric, succinic, and L-malic acids involved in the glyoxylate cycle significantly accumulated and the malate synthetase gene was up-regulated in barren-tolerant wild soybean cotyledons. (bvsalud.org)
Acid3
- Souble δ-aminolevulinic acid synthetase of rat liver. (unipr.it)
- 5-Aminolevulinic acid (5-ALA), a non-proteinogenic five-carbon amino acid, has received intensive attentions in medicine due to its approval by the US Food and Drug Administration (FDA) for cancer diagnosis and treatment as photodynamic therapy. (springeropen.com)
- Pyruvic acid and citric acid involved in pyruvate-citrate metabolism increased distinctly and genes encoding pyruvate decarboxylase and citrate synthetase were up-regulated. (bvsalud.org)
Plants3
- 1997 ). When plants are treated with high concentration of 5-ALA and exposed to light, the ROS produced by excess PPIX will oxidize unsaturated fatty acids, thereby damaging plants. (springeropen.com)
- Previous studies showed that the yield and quality of plants and crops could be improved by 5-ALA (Hotta et al. (springeropen.com)
- 2013 ). As a conclusion, 5-ALA is able to promote seedling growth of plants by raising chlorophyll content and net photosynthetic rate to prevent stress damage (Naeem et al. (springeropen.com)
Genes1
- In this review, we describe the recent results of 5-ALA production from different genes and microorganisms via genetic and metabolic engineering approaches. (springeropen.com)
Results1
- Results 1-5 of 5 (Search time: 0.002 seconds). (who.int)
Medicine1
- In addition to the application in medicine, 5-ALA has also been employed in the agriculture as it is harmless and belongs to biodegradable herbicide and insecticide, growth-promoting factor, thus enhancing the productivity of crops (Hotta et al. (springeropen.com)
Treatment1
- 5-ALA has been tested and applied as a prodrug for leukemia cells treatment (Malik and Lugaci 1987 ). (springeropen.com)
Source1
- alanyl-tRNA synthetase 1 [Source:HGNC Symb. (gsea-msigdb.org)
Thymidylate2
- It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and inhibiting thymidylate synthetase and, subsequently, cell proliferation. (medscape.com)
- 5-FU inhibits thymidylate synthetase, limiting DNA synthesis and causing death of damaged cells. (merckmanuals.com)
Enzyme3
- An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. (nih.gov)
- A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-dependent condensation of L-SERINE and PALMITOYL COENZYME A to 3-dehydro-D-sphinganine. (childrensmercy.org)
- The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. (nih.gov)
Endogenous2
- LEVULAN® KERASTICK® (aminolevulinic acid HCl) for Topical Solution, 20%, contains the hydrochloride salt of aminolevulinic acid (ALA), an endogenous 5-carbon aminoketone. (nih.gov)
- As a precursor of photoactive porphorins, hexyl 5-aminolevulinate induces the endogenous production of the photosensitizer protoporphyrin IX (PPIX) which accumulates selectively in tumor tissue. (xcessbio.com)
Pyridoxal11
- These vitB6 compounds (also called vitamers) are pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL) and their 5′-phosphorylated forms pyridoxine 5′-phosphate (PNP), pyridoxamine 5′-phosphate (PMP) and pyridoxal 5′-phosphate (PLP). (intechopen.com)
- Pyridoxal phosphate, also known as PLP, pyridoxal 5'-phosphate or P5P, is the active form of vitamin B6. (hmdb.ca)
- Pyridoxal 5'-phosphate belongs to the class of organic compounds known as pyridoxals and derivatives. (hmdb.ca)
- Pyridoxals and derivatives are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively. (hmdb.ca)
- Pyridoxal 5'-phosphate is a drug which is used for nutritional supplementation and for treating dietary shortage or imbalance. (hmdb.ca)
- Pyridoxal 5'-phosphate exists in all living species, ranging from bacteria to humans. (hmdb.ca)
- In humans, pyridoxal 5'-phosphate is involved in glycine and serine metabolism. (hmdb.ca)
- Outside of the human body, pyridoxal 5'-phosphate is found, on average, in the highest concentration within cow milk. (hmdb.ca)
- Pyridoxal 5'-phosphate has also been detected, but not quantified in several different foods, such as soursops, italian sweet red peppers, muscadine grapes, european plums, and blackcurrants. (hmdb.ca)
- Pyridoxal 5'-phosphate, with regard to humans, has been found to be associated with several diseases such as epilepsy, early-onset, vitamin B6-dependent, odontohypophosphatasia, pyridoxamine 5-prime-phosphate oxidase deficiency, and hypophosphatasia. (hmdb.ca)
- Pyridoxal 5'-phosphate has also been linked to the inborn metabolic disorder celiac disease. (hmdb.ca)
Imiquimod1
- Topical fluorouracil (5-FU) cream and imiquimod cream are the usual first-line drug treatments. (merckmanuals.com)
Fluorouracil2
- The most common chemotherapeutic agent used in superficial basal cell carcinoma is topical 5-fluorouracil. (medscape.com)
- 5-Fluorouracil topical 5% cream or solution is used topically for the management of superficial BCC. (medscape.com)
Methyl1
- Methyl aminolevulinate cream is a porphyrin precursor used in combination with narrow-band, red-light illumination for nonhyperkeratotic, nonpigmented actinic keratoses. (medscape.com)
Fluorescence3
- 5. Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway. (nih.gov)
- Sievert KD, Kruck S. Hexyl aminolevulinate fluorescence cystoscopy in bladder cancer. (xcessbio.com)
- Hexyl aminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer: a critical review of the current literature. (xcessbio.com)
Ester1
- Hexaminolevulinate hydrochloride, also known as hexyl 5-aminolevulinate HCl, is the hexyl ester of 5-aminolevulinic acid (ALA) with photodynamic properties. (xcessbio.com)
Hydrochloride2
- The chemical name for ALA HCl is 5-amino-4-oxopentanoic acid hydrochloride (MW = 167.59). (nih.gov)
- hexyl 5-amino-4-oxopentanoate hydrochloride. (xcessbio.com)
Photodynamic3
- 2. Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer. (nih.gov)
- 3. Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4. (nih.gov)
- Artificial daylight photodynamic therapy with "non-inflammatory" doses of hexyl aminolevulinate only marginally delays SCC development in UV-exposed hairless mice. (xcessbio.com)
Protoporphyrin1
- 11. Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer. (nih.gov)
Activity1
- ALA synthetase activity is also closely associated with cytochrome P-450 activity. (medscape.com)
Data1
- Our data in HeLa cells show a pattern of 5 peaks using a pan PAK1/2/3 antibody of which two are picked up consistently by 3 different specific PAK2 antibodies identifying them as PAK2 peaks. (proteinsimple.com)
Cream1
- 5-FU 5% cream is applied 2 times a day for 3 to 4 weeks. (merckmanuals.com)
Group1
- A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17. (mcw.edu)
Type1
- zinc finger AN1-type containing 5 [S. (gsea-msigdb.org)