5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole: A nitrovinyl furan used as a schistosomicidal agent and proposed for trypanosomiasis, especially Chagas disease.OxadiazolesVinyl CompoundsVinyl Chloride: A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.NitrofuransThiadiazolesQuinoxalinesGuanylate Cyclase: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.Nitric Oxide Donors: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Receptor, Adenosine A2A: A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Adenosine A2 Receptor Antagonists: Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.PolyvinylsNitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Nitroblue Tetrazolium: Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.ThiazolesAdenosine A2 Receptor Agonists: Compounds that selectively bind to and activate ADENOSINE A2 RECEPTORS.Nitroreductases: Enzymes which reduce nitro groups (NITRO COMPOUNDS) and other nitrogenous compounds.Furylfuramide: Used formerly as antimicrobial food additive. It causes mutations in many cell cultures and may be carcinogenic.Purinergic P1 Receptor Antagonists: Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Polyvinyl Chloride: A polyvinyl resin used extensively in the manufacture of plastics, including medical devices, tubing, and other packaging. It is also used as a rubber substitute.Saccharin: Flavoring agent and non-nutritive sweetener.TriazolesReceptors, Purinergic P1: A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).Triazines: Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Purinergic P1 Receptor Agonists: Compounds that bind to and stimulate PURINERGIC P1 RECEPTORS.Polyvinyl Alcohol: A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products.Antimutagenic Agents: Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Ferula: A plant genus of the family APIACEAE. It contains pungent oils and resins. It is used to flavor curries, as a carminative, and as cat and dog repellent. The occasionally used common name of 'giant fennel' should not be confused with true fennel (FOENICULUM).Phenethylamines: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)Adenosine-5'-(N-ethylcarboxamide): A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.Pyelitis: Inflammation of the KIDNEY PELVIS and KIDNEY CALICES where urine is collected before discharge, but does not involve the renal parenchyma (the NEPHRONS) where urine is processed.Trinitrotoluene: A 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.AcrylatesAdenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Xanthines: Purine bases found in body tissues and fluids and in some plants.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Thermolysin: A thermostable extracellular metalloendopeptidase containing four calcium ions. (Enzyme Nomenclature, 1992) 3.4.24.27.Kinetics: The rate dynamics in chemical or physical systems.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Hemangiosarcoma: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Nitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Receptor, Adenosine A1: A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Perfume: A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Tritrichomonas: A genus of flagellate EUKARYOTES possessing three long anterior flagella.IndazolesDichloroethylenes: Toxic chlorinated unsaturated hydrocarbons. Include both the 1,1- and 1,2-dichloro isomers. Both isomers are toxic, but 1,1-dichloroethylene is the more potent CNS depressant and hepatotoxin. It is used in the manufacture of thermoplastic polymers.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.
... oxadiazoles MeSH D03.383.129.462.580.200 --- 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 ... vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin MeSH D03.383.312.649.313 --- ... alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid MeSH D03.383.129.385.162 --- cycloserine MeSH D03.383.129.385.231 --- ... 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ...
... vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH D02.640.600.313 --- furazolidone ... vinyl compounds MeSH D02.455.326.271.884.533 --- polyvinyls MeSH D02.455.326.271.884.533.532 --- polyvinyl alcohol MeSH D02.455 ... vinyl chloride MeSH D02.455.326.397 --- alkynes MeSH D02.455.326.397.259 --- acetylene MeSH D02.455.326.397.300 --- ... vinyl chloride MeSH D02.455.526.510 --- hydrocarbons, fluorinated MeSH D02.455.526.510.140 --- chlorofluorocarbons MeSH D02.455 ...
... (Picovir) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus. It has shown useful activity against the dangerous strain enterovirus D68. Pleconaril was originally developed by Sanofi-Aventis, and licensed to ViroPharma in 1997. ViroPharma developed it further, and submitted a New Drug Application to the United States Food and Drug Administration (FDA) in 2001. The application was rejected, citing safety concerns; and ViroPharma re-licensed it to Schering-Plough in 2003. The Phase II clinical trial was completed in 2007. A pleconaril intranasal spray had reached phase II clinical trial for the treatment of the common cold symptoms and asthma complications. However, the results have yet to be reported. In ...
Most NONOates are stable in alkaline solution above pH 8.0 (e. g. 10 mM NaOH) and can be stored at −20 °C in this way for the short term. To generate NO from NONOates, the pH is lowered accordingly. Typically, a dilution of the stock NONOate solution is made in a phosphate buffer (pH 7.4; tris buffers can also be used) and incubated at room temperature for the desired time to allow NO to accumulate in solution. This is often visible as bubbles at high NONOate concentrations. Incubation time is important, since the different NONOates have different half-lives (t½) in phosphate buffer at pH 7.4. For example, the half-life of MAHMA NONOate under these conditions is ~3.5 minutes, whilst the t½ of DPTA NONOate is 300 minutes. This is often useful in biological systems, where a combination of different NONOates can be used to give a sustained release of nitric oxide. At pH 5.0, most NONOates are considered to decompose almost instantaneously. ...
... (DVB) consists of a benzene ring bonded to two vinyl groups. It is related to styrene (vinylbenzene) by the addition of a second vinyl group.[2] It is a colorless liquid manufactured by the thermal dehydrogenation of isomeric diethylbenzenes. Under synthesis conditions, o-divinylbenzene converts to naphthalene and thus is not a component of the usual mixtures of DVB.[3] ...
An additional stabilizing factor in this enzyme-substrate complex is hydrogen bonding between the lone pair of the oxygen in the vinyl ether system and hydrogen bond donor residues. Not only does this stabilize the complex, but disruption of resonance within the vinyl ether destabilizes the ground state and reduces the energy barrier for this transformation. An alternative view is that electrostatic stabilization of the polarized transition state is of great importance in this reaction. In the chorismate mutase active site, the transition-state analog is stabilized by 12 electrostatic and hydrogen-bonding interactions.[8] This is shown in mutants of the native enzyme in which Arg90 is replaced with citrulline to demonstrate the importance of hydrogen bonding to stabilize the transition state.[9] Other work using chorismate mutase from Bacillus subtilis showed evidence that when a cation was aptly placed in the active site, the electrostatic interactions between it and the ...
... is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. There are many well-known ototoxic drugs used in clinical situations, and they are prescribed, despite the risk of hearing disorders, to very serious health conditions. Ototoxic drugs include antibiotics such as gentamicin, loop diuretics such as furosemide and platinum-based chemotherapy agents such as cisplatin. A number of nonsteroidal anti-inflammatory drugs (NSAIDS) have also been shown to be ototoxic.[citation needed] This can result in sensorineural hearing loss, dysequilibrium, or both. Some environmental and occupational chemicals have also been shown to affect the auditory system and interact with noise. Symptoms of ototoxicity include partial or profound hearing loss, ...
The Petasis reaction (alternatively called the Petasis borono-Mannich (PBM) reaction) is the chemical reaction of an amine, aldehyde, and vinyl- or aryl-boronic acid to form substituted amines. Reported in 1993 by Nicos Petasis as a practical method towards the synthesis of a geometrically pure antifungal agent, naftifine, the Petasis reaction can be described as a variation of the Mannich reaction. Rather than generating an enolate to form the substituted amine product, in the Petasis reaction, the vinyl group of the organoboronic acid serves as the nucleophile. In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a variety of amines and organoboronic acids as potential starting materials. Additionally, the reaction does not require anhydrous or inert conditions. As a mild, selective synthesis, the Petasis reaction is useful in generating α-amino acids, and is utilized in combinatorial ...
Allylstannanes are relatively stable reagents in the allylmetal family, and have been employed in a variety of complex organic syntheses. In fact, allylstannane addition is one of the most common methods for producing polypropionates, polyacetates, and other oxygenated molecules with a contiguous arrays of stereocenters.[10] Ley and coworkers[11] used an allylstannane to allylate a threose-derived aldehyde (see figure) en route to the macrolide antascomicin B, which structurally resembles FK506 and rapamycin, and is a potent binder of FKBP12. Allylboration is also often used to add allyl groups in a 1,2 fashion to aldehydes and ketones. Thanks to decades of research, there is now a wide variety of organoboron reagents available to the synthetic chemist, including organoboranes that predictably yield products in high diastereo- and enantioselectivity.[12] If a one-pot metal insertion and allylation procedure is required, indium- mediated allylation is an attractive option for generating ...
Nurse is the first major label album released by the band Therapy?.[3] It was released on 2 November 1992 on A&M Records. The album was mainly recorded at Loco Studio in Caerleon, Wales, apart from "Gone" which was recorded in Annamoe, Ireland.[4] It marked a departure from the noise punk style of the two mini-albums, being a more industrial-sounding record. The album was rated favourably by critics and reached number 38 in the UK Albums Chart.[5]. The album was released on 12" vinyl, CD and cassette. In the US, the album was released on limited edition red 12" vinyl, CD and cassette.. A remastered CD version of the album by the original producer, Harvey Birrell, was included in The Gemil Box, released on 18 November 2013.. The original master of the album was used for a 'Music on Vinyl' audiophile re-issue, released on mixed red and gold 180g vinyl on 22 February 2016, limited to 1000 copies[6]. The album can be seen in the background of a ...
Edison Laser Player (ELP) Japan is a Japanese audio equipment company started by Sanju Chiba, who manufacture laser turntables. The origin of ELP's turntable came from an American company named Finial Technologies, led by Michael Stoddard, who designed a prototype unit for playing vinyl using laser technology in the mid-1980s. Unfortunately, this coincided with the commercial rise of the CD, so Finial went into receivership and sold the rights to ELP in 1989. The units are custom built to order - a typical price in the mid-2000s was about $11,000 to $15,000. The turntable uses a combination of five lasers, which point in different directions of the groove in a vinyl record to ensure a steady signal is picked up. Because of laser technology, loading and unloading a vinyl record is similar to the process used in most high end CD players. The lack of mechanical components means it is far more capable of playing records, even those with scratches and warps, and ...
To avoid over-hyping the album, DGC Records took a low-key approach to promoting In Utero; the company's head of marketing told Billboard before the album's release that the label was taking a promotional strategy similar to that of Nevermind, and explained that the label would "set things up, duck, and get out of the way". The label aimed its promotion at alternative markets and press, and released the album on vinyl record as part of this strategy.[74] In contrast to the previous album, the label did not release any of In Utero's singles commercially in the United States.[8] DGC sent promo copies of the album's first single, "Heart-Shaped Box", to American college, modern rock, and album-oriented rock radio stations in early September, but the label did not target Top 40 radio.[74] Despite the label's promotion, the band was convinced that In Utero would not be as successful as Nevermind. Cobain told Jim DeRogatis, "We're certain that we won't sell a quarter as much, and we're totally ...
... are a post-rock band based in the English cities of Leicester and Leeds. After playing live throughout the United Kingdom to much critical acclaim, with the likes of iLiKETRAiNS and The Twilight Sad, they released their debut album, The Heritage, in 2008, which was also positively acclaimed, and was followed by a well-received headlining tour. The album lasts over 50 minutes, despite only containing six tracks. In February 2009, they announced their arrival on the German label, Denovali Records. Denovali re-released The Heritage on vinyl in late 2009. The band released The Quiet Lamb, containing 12 tracks and lasting over 75 minutes, on 8 November 2010. NME gave it a score of 8/10, describing it as "massive, pastorally apocalyptic music". The Sun called it a "ten-track jewel of a record" that engages the listener "in a rare and beautiful way". The Quiet Lamb is ranked the 12th best Post Rock album of all time in a poll of fans and reviewers with a critic's score of 83. In 2014 ...
Irregular bleeding and spotting: Many women will experience some type of irregular, unpredictable, prolonged, frequent, or infrequent bleeding when using Nexplanon or Implanon.[18] Some women also experience amenorrhea. For some women, prolonged bleeding will decline after the first three months of use. However, other women may experience this bleeding pattern through all three years of use. While these patterns are not dangerous, they are the most common reason that women give for discontinuing the use of the implant. After removal, bleeding patterns return to previous patterns in most women.[13][14][15][16]. Insertion complications: Some minor side effects such as bruising, skin irritation, or pain around the insertion site are common.[13] However, there are some rare complications that can occur, such as infection or expulsion.[13][19] In some cases, a serious complication occurs when the provider fails to insert, and the rod is left in the inserter. An Australian study reported 84 ...
Born in Aachen in 1810, he moved to Paris at the age of eight, following the death of his parents. There, he worked for an upholstery firm until he was eighteen. In 1830, he was admitted to the École Polytechnique, and in 1832 he graduated from the École des mines. Working under Justus von Liebig at Gießen, Regnault distinguished himself in the nascent field of organic chemistry by synthesizing several chlorinated hydrocarbons (e.g. vinyl chloride[1], polyvinylidene chloride, dichloromethane), and he was appointed professor of chemistry at the University of Lyon. In 1840, he was appointed the chair of chemistry of the École Polytechnique, and in 1841, he became a professor of Physics in the Collège de France. Beginning in 1843, he began compiling extensive numerical tables on the properties of steam. These were published in 1847, and led to his receiving the Rumford Medal of the Royal Society of London and appointment as Chief Engineer of Mines. In 1851 he was elected a ...
... vinyl)-1,2,4-oxadiazole. A nitrovinyl furan used as a schistosomicidal agent and proposed for trypanosomiasis, especially ... A phase 2 clinical trial to evaluate the the efficacy of different benznidazole regimens (300mg/day for 60 days, 150mg/day for ... Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and ...
... oxadiazoles MeSH D03.383.129.462.580.200 --- 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 ... vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin MeSH D03.383.312.649.313 --- ... alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid MeSH D03.383.129.385.162 --- cycloserine MeSH D03.383.129.385.231 --- ... 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ...
D12 - AMINO ACIDS, PEPTIDES, AND PROTEINS. Adaptor Proteins. Adaptor Proteins, Vesicular Transport. ... vinyl)-1,2,4-oxadiazole. D03 - HETEROCYCLIC COMPOUNDS. Bay-K-8644. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro- ... 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone. Ro 4-1284. 2H-Benzo(a)quinolizin-2-ol 2-Ethyl-1,3,4,6,7,11b-hexahydro-3- ... Pregnancy-Specific beta 1-Glycoprotein. Pregnancy-Specific beta 1-Glycoproteins. Tissue Inhibitor of-Metalloproteinase-3. ...
... vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH D02.640.600.313 --- furazolidone ... vinyl compounds MeSH D02.455.326.271.884.533 --- polyvinyls MeSH D02.455.326.271.884.533.532 --- polyvinyl alcohol MeSH D02.455 ... vinyl chloride MeSH D02.455.326.397 --- alkynes MeSH D02.455.326.397.259 --- acetylene MeSH D02.455.326.397.300 --- ... vinyl chloride MeSH D02.455.526.510 --- hydrocarbons, fluorinated MeSH D02.455.526.510.140 --- chlorofluorocarbons MeSH D02.455 ...
... vinyl]-1,3,4-oxadiazole. 2B. 7, Sup 7. 1987. ... A-alpha-C (2-Amino-9H -pyrido[2,3-è ]indole). 2B. 40, Sup 7. ... 3. 10, Sup 7. 1987. 27208-37-3. Cyclopenta[crf ]pyrene. 2A. Sup 7, 92. 2010. NB: Overall evaluation upgraded to Group 2A with ... 33229-34-4. HC Blue No. 2. 3. 57. 1993. 33419-42-0. Etoposide. 1. 76, 100A. 2012. NB: Overall evaluation upgraded to Group 1 ... 1-tert -Butoxypropan-2-ol. 2B. 88, 119. In prep.. 57117-31-4. 2,3,4,7,8-Pentachlorodibenzofuran. 1. 100F. 2012. NB: Overall ...
... vinyl)-1,2,4-oxadiazole S1P Receptor use Receptors, Lysosphingolipid ... SAP Kinase 3 use Mitogen-Activated Protein Kinase 12 SAP Kinase Extracellular Signal Regulated Kinase Kinase 1 use MAP Kinase ... SAP Kinase-3 use Mitogen-Activated Protein Kinase 12 SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1 use MAP Kinase ... S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid use Amifostine S-100 Calcium-Binding Protein beta Subunit use S100 ...
... amino]ethyl}amino)ethanol; [0070] N-(3-methoxyphenyl)-4-propoxybenzamide; [0071] 2-(4-hydroxyphenyl)-3-phenyl-2,3-dihydro-4(1H ... vinyl]b- enzamide; [0054] 2-chloro-N-(3-chloro-4-methoxyphenyl)benzamide; [0055] 2,6-di-tert-butyl-4-(2,3-dihydro-1H-perimidin- ... furyl}-1H-isoindole-1,3(2H)-dione; [0068] N-(2,5-dimethylphenyl)-3-(4-methoxyphenyl)acrylamide; [0069] 2-({2-[(4-nitrophenyl) ... oxadiazole 38 ##STR00052## 272.1 C9 H7 Cl2 N5 O N-(3,4-dichlorophenyl)- N-4H-1,2,4-triazol-4- ylurea 52 ##STR00053## 475.9 C27 ...
... an amino group having from 0 to 50 carbon atoms (e.g., amino, methylamino, diethylamino, diisopropylamino, anilino, or ... 4,960,681 and JP-A-62-245260, specifically, a homopolymer of vinyl monomer having --COOM or --SO3 M (wherein M represents a ... a nitro group, a carboxy group, a hydroxy group, a sulfo group, a mercapto group, an alkylsulfinyl group having from 1 to 50 ... an aliphatic amino group, an arylamino group, a heterocyclic amino group, an aliphatic oxycarbonylamino group, an ...
3/4 Inch Concrete Chisel, 1 Inch Cold Chisel, 3 Inch Floor Chisel, 4 Inch Brick Chisel, 3 Pound Deadblow Hammer, & 3 Pound Club ... Vinyl cyclohexenedioxide),Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide),Vinyl fluoride,"Vinylidene chloride ,(1,1 ... nitro-N-nitrosoguanidine,N-Methylolacrylamide,N-Methylpyrrolidone,à-Methyl styrene (alpha-Methylstyrene),à-Methyl styrene ... amino]-2-oxazolidinone, MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone),Myclobutanil,beta-Myrcene,Nabam,Nafarelin ...
Vinyl cyclohexenedioxide),Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide),Vinyl fluoride,"Vinylidene chloride ,(1,1 ... nitro-N-nitrosoguanidine,N-Methylolacrylamide,N-Methylpyrrolidone,à-Methyl styrene (alpha-Methylstyrene),à-Methyl styrene ... amino]-2-oxazolidinone, MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone),Myclobutanil,beta-Myrcene,Nabam,Nafarelin ... Vinyl bromide,Vinyl chloride,4-Vinylcyclohexene,4-Vinylcyclohexene,4-Vinyl-1-cyclohexene diepoxide ( ...
Vinyl cyclohexenedioxide),Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide),Vinyl fluoride,"Vinylidene chloride ,(1,1 ... nitro-N-nitrosoguanidine,N-Methylolacrylamide,N-Methylpyrrolidone,à-Methyl styrene (alpha-Methylstyrene),à-Methyl styrene ... amino]-2-oxazolidinone, MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone),Myclobutanil,beta-Myrcene,Nabam,Nafarelin ... Vinyl bromide,Vinyl chloride,4-Vinylcyclohexene,4-Vinylcyclohexene,4-Vinyl-1-cyclohexene diepoxide ( ...
... vinyl chloride/vinyl acetate copolymers, polyvinyl acetate, polyvinylidene chloride, polyarylate, polycarbonate, cellulose ... 6) amino groups substituted with an alkyl group, which have a formula, --N(R.sub.110) (R.sub.111). [0220] Specific examples of ... 0191] Specific examples of the heterocyclic ring groups include thienyl groups, benzothienyl groups, furyl groups, benzofuryl ... 0164] Specific examples of the positive-hole transport materials include oxazole derivatives, oxadiazole derivatives, imidazole ...
Vinyl bromide, Vinyl chloride, Vinyl cyclohexene dioxide, Vinyl fluoride, Vinyl trichloride (1,1,2-Trichloroethane), Warfarin, ... nitro-N-nitrosoguanidine, N-Methylolacrylamide, N-Methylpyrrolidone, N-Nitroso-N-ethylurea, N-Nitroso-N-methylurea, N-Nitroso-N ... amino]-2-oxazolidinone, 5-Chloro-o-toluidine and its strong acid salts, 5-Methoxypsoralen with ultraviolet A therapy, 5- ... Vinyl bromide, Vinyl chloride, Vinyl cyclohexene dioxide, Vinyl fluoride, Vinyl trichloride (1,1,2-Trichloroethane), Warfarin, ...
... nitro-2-furyl)-s-triazine- 2,4-diyl]bisacetamide ... amino]-2-imidazolidinone. 3775-55-1 2-amino-5-(5-nitro-2-furyl ... vinyl]-1,3,4-oxadiazole. 66-75-1 ... anti-4,5-dihydroxy-6,6a-epoxy-4,5,6,6a-tetrahydrobenzo[j] ...
Vinyl bromide. Epichlorohydrin. Vinyl chloride. Ethyl acrylate. Vinyl cyclohexene dioxide. Ethylene dibromide. Vinylidene ... N-Methyl-N-nitro-N-nitrosoguanidine. Metronidazole. Mirex. Nickel. Nickel acetate. Nickel carbonate. Nickel carbonyl. Nickel ... furyl)acrylamide]. 1,2-Diethylhydrazine. Aflatoxin M1. Diglycidyl resorcinol ether. para-Aminoazobenzene. Dihydrosafrole. ortho ... Vinyl bromide. Diesel exhaust. Vinyl fluoride. Table 2: Các hóa chất có nguy cơ gây ung thư trong cơng nghiệp được liệt. kê bởi ...
... vinyl]-1,3,4- oxadiazole 7,12-Dimethylbenz(a)anthracene ... N-Methyl-N-nitro-N-nitrosoguanidine (MNNG) *N-Methyl-N- ... amino]-2-imidazollidinone *1-[(5-Nitrofurfurylidene)-N-[4-(5-Nitro-2-furyl)-2 thiazolyl]acetamide ... 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) *1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl ... 3,3-Dimethoxybenzidine (ortho-Dianisidine) *3,3-Dimethoxybenzidine dihydrochloride (ortho-dianisidine dihydrochloride) para- ...
... vinyl]-1,3,4-oxadiazole Office of Environmental Health Hazard Assessment. Proposition 65 No Significant Risk Levels (NSRLs) for ... amino]-2-imidazolidinone N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide Office of Environmental Health Hazard Assessment. ... Vinyl trichloride (1,1,2-Trichloroethane) a Where a source or product results in exposures by multiple routes, the total ... amino]-2-oxazolidinone MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) Nickel refinery dust from the pyrometallurgical ...
Vinyl cyclohexene dioxide). n-vinyl pyrollidone. Vinyl trichloride (1,1,2-Trichloroethane) X. 2,6-Xylidine (2,6-Dimethylaniline ... N-Methyl-N-nitro-N-nitrosoguanidine (MNNG). N-Methyl-N-nitrosourea. N-Methylolacrylamide. Methylthiouracil. Metiram. ... amino]-2-oxazolidinone. Mustard gas N. Nafenopin. 1-Naphthylamine. 2-Naphthylamine. 3-Naphthylamine. Nickel and certain nickel ... oxadiazole. 7,12-Dimethylbenz(a)anthracene. 3,3-Dimethylbenzidine (ortho-Tolidine). 3,3-Dimethylbenzidine dihydrochloride. ...
Heavy duty steel frame sets up easily in seconds Single unit replaces 3-8 sawhorses, saving labor and materials Compact ... Vinyl cyclohexenedioxide),Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide),Vinyl fluoride,"Vinylidene chloride ,(1,1 ... nitro-N-nitrosoguanidine,N-Methylolacrylamide,N-Methylpyrrolidone,à-Methyl styrene (alpha-Methylstyrene),à-Methyl styrene ... amino]-2-oxazolidinone, MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone),Myclobutanil,beta-Myrcene,Nabam,Nafarelin ...
Other examples include vinyl urethane compounds comprising in its molecule two or more of polymerizable vinyl group, which can ... 3,751,259, and oxadiazoles disclosed in U.S. Pat. No. 4,212,970. The amount of these compounds ranges from about 0.5% to about ... Compounds comprising sulfonic acid group may be substituted by lower alkyl group, nitro group, halo group and/or an additional ... Although a variety of polymers can be used as a binder, a polymer comprising hydroxy, amino, carboxylic acid, amide, ...
The electron donating group is preferably an alkoxy group or an N,N-disubstituted amino group, and most preferably an alkoxy ... Specific examples of hetero atoms include imidazolyl, pyridyl, quinolyl, furyl, thienyl, piperidil, morpholino, benzoxazolyl, ... Examples of such materials include carbazole, triazole, oxazole, oxadiazole, imidazole, polyarylalkanes, pyrazoline, pyrazolone ... such as vinyl, allyl, 2-butenyl and 3-pentenyl); an alkynyl group (preferably having 2 to 30 carbon atoms, more preferably 2 to ...
R126 is preferably a hydrogen atom, an alkyl group, an alkoxy group or a substituted amino group (preferably dialkylamino or ... The aromatic nitrogen-containing ring preferably includes a pyrazole ring, a triazole ring, an oxadiazole ring, a thiadiazole ... a nitro group, a hydroxamic acid group, a sulfino group, a hydrazino group, an imino group, a heterocyclic group (containing a ... such as vinyl, allyl, 2-butenyl or 3-pentenyl), an alkynyl group (preferably having 2 to 30 carbon atoms, still preferably 2 to ...
... amino, methylamino, diethylamino, diisopropylamino, anilino, and morpholino), a cyano group, a nitro group, a carboxyl group, a ... vinyl, 1-methylvinyl, and cyclohexen-1-yl), an alkynyl group having of 2 to 50 carbon atoms (for example, ethynyl and 1- ... an amino group, an anilino group, a heterocycle-amino group, an alkylthio group, an arylthio group, a heterocycle-thio group, a ... The polymer mordants used herein include polymers having tertiary amino groups, polymers having nitrogen-containing ...
6-Nitro-1,2,3,4-tetrahydroquinoline. EC-000.1581. View structure. (2-Amino-4-hydroxy-1,3-thiazol-5-yl)acetic acid. EC-000.1582 ... Amino-carbamimidoylimino-methanesulfinic acid. EC-000.1615. View structure. 1,3-Thiazole-2-carboxamide. EC-000.1616. View ... vinyl]-3-phenyl-4(3H)-quinazolinone. EC-000.1701. View structure. ... 6-Nitro-2-quinolinecarbaldehyde. EC-000.1567. View structure. 5-{[(2-cyanoethyl)sulfanyl]methyl}-2-furoic acid. EC-000.1568. ...
Similarly, following the procedure of Example 1A, but replacing amino-N-ethylamide with amino-N-methylamide, 6-amino-1-methyl-1 ... vinyl). Preferred alkenyl groups include ethenyl or vinyl (--CH.dbd.CH.sub.2), 1-propylene or allyl (--CH.sub.2CH.dbd.CH.sub.2 ... Such heteroaryl groups can have a single ring (e.g., pyridyl or furyl) or multiple condensed rings (e.g., indolizinyl, ... nitro, --SO-alkyl, --SO-aryl, --SO-heteroaryl, --SO.sub.2-alkyl, SO.sub.2-aryl and --SO.sub.2-heteroaryl. Unless otherwise ...
  • 4. The process of claim 3, wherein R.sup.1 and R.sup.2 are independently lower alkyl, Y is methylene, and Z is optionally substituted phenyl. (patentgenius.com)
  • 12. The process of claim 6, wherein R.sup.1 and R.sup.2 are independently lower alkyl, X is pyrazol-4-yl, Y is methylene, and Z is optionally substituted phenyl. (patentgenius.com)
  • 18. The process of claim 17, wherein R.sup.1 and R.sup.2 are independently lower alkyl, X is pyrazol-4-yl, Y is methylene, and Z is optionally substituted phenyl. (patentgenius.com)
  • 20. The method according to claim 16, wherein said DOCK5 protein refers to a polypeptide comprising the DHR2 domain of the protein DOCK5 corresponding to the amino acid 1132 to 1661 of the DOCK5 protein from Mus musculus SEQ ID NO:1 and derivatives thereof. (patentsencyclopedia.com)
  • 5. The electroconductive polymer composition according to claim 1, further comprising polystyrene sulfonic acid as dopant. (patents.com)
  • All of these receptors are broadly distributed in cells and tissues throughout the body, but SI Pi, SI P3 and S1P4 are predominantly expressed in lymphocyte and endothelial cell, SIP2 is predominantly expressed in vascular smooth muscle cell, and SIP5 is predominantly expressed in brain and spleen, and amino acid sequences thereof are well-conserved in human and rodent (Non-Patent Document 1). (allindianpatents.com)
  • For example, as a compound having SIPi agonist activity, a carboxylic acid derivative represented by the following formula has been known (Patent Document 1). (allindianpatents.com)
  • 15. The process of claim 14, wherein R.sup.1 is lower alkyl optionally substituted by cycloalkyl, and L is iodo. (patentgenius.com)
  • In Formulae (I) to (IV), R.sup.1 to R.sup.12 each independently represent a hydrogen atom, an alkyl group, an aryl group or a heteroaryl group. (patents.com)
  • Cyclins are a family of proteins characterised by a homology region, containing approximately 100 amino acids, termed the "cyclin box" which is used in binding to, and defining selectivity for, specific CDK partner proteins. (allindianpatents.com)
  • The binding of Gβγ is approximately the area length of 100 amino acids, which is part of plastikowego homology (PH) domain, found in ARTICLE GRK2. (russianpatents.com)
  • 3. The photoreceptor according to claim 2, wherein the charge transport material is a charge transport polymer. (patents.com)
  • 4. The photoreceptor according to claim 3, wherein the charge transport polymer has a triaryl amine structure. (patents.com)
  • 1. An electroconductive polymer composition comprising an electroconductive polymer having an electroconductivity of 10.sup. (patents.com)
  • and n.sup.11 is an integer of 1 or greater, and wherein a compounding ratio of the trivalent phosphorus compound and the electroconductive polymer (trivalent phosphorus compound:electroconductive polymer) is in a range of from 0.05:1.2 to 1:1.2 by mass ratio. (patents.com)
  • 2. The electroconductive polymer composition according to claim 1, wherein the trivalent phosphorus compound is a compound represented by Formula (I). (patents.com)
  • 4. The electroconductive polymer composition according to claim 1, wherein the electroconductive polymer includes poly(3,4-ethylenedioxy)thiophene. (patents.com)
  • 6. The electroconductive polymer composition according to claim 1, further comprising water to be in a state of dispersion. (patents.com)
  • and a layer formed by using the electroconductive polymer composition according to claim 1 on or above the support. (patents.com)
  • 4. A material according to claim 2 , characterized in that the onium cation is part of a recurring unit of a polymer. (google.com)
  • 5. A material according to claim 2 , characterized in that the cation M is a cationic heterocycle with aromatic character, including at least one alkylated nitrogen atom in the cycle. (google.com)
  • Patent Literature 1 discloses to use a compound having a fluoranthene skeleton in which the carbon atom(s) at 7-position and/or 10-position is(are) replaced by a nitrogen atom or nitrogen atoms in an organic EL device. (justia.com)
  • Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions. (ctdbase.org)
  • 3. The process of claim 2, wherein the inert solvent is methanol and the base is aqueous sodium hydroxide solution. (patentgenius.com)
  • wherein R 41 , R 42 , R 43 , R 44 and R 45 each independently represent a substituent, L 41 represents a ligand, X 4 represents a counter anion, m 41 and m 42 each independently represent an integer of 0 to 4, and n 41 represents 0 or 1. (google.co.uk)
  • wherein R 51 , R 52 , R 53 R 54 , R 55 and R 56 each independently represent a substituent, Z 51 represents a linkage group, X 51 represents a counter anion, and m 51 and m 52 each independently represent an integer of 0 to 4. (google.co.uk)
  • This invention relates to pyrazole compounds that inhibit or modulate the activity of cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3), to the use of the compounds in the treatment or prophylaxis of disease states or conditions mediated by cyclin dependent kinases and glycogen synthase kinase-3, and to novel compounds having cyclin dependent kinase or glycogen synthase kinase-3 inhibitory or modulating activity. (allindianpatents.com)
  • SUBSTANCE: compounds are suitable for use as kinase 1β-adrenergic receptor (βARK-1) inhibitors. (russianpatents.com)
  • wherein R 61 , R 62 , R 63 , R 64 and R 65 each independently represent a substituent, Z 61 represents a linkage group, and m 61 and m 62 each independently represent an integer of 0 to 4. (google.co.uk)
  • 3. A material according to claim 2 , characterized in that the onium cation is part of the Y c or the substituent Q. (google.com)
  • NSRL (µg/day)a MADL (µg/day)a 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) Tris(1-aziridinyl)phosphine sulfide (Thiotepa) Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) Vinyl trichloride (1,1,2-Trichloroethane) a Where a source or product results in exposures by multiple routes, the total exposure must be considered. (drugstorepdfsearch.com)
  • 7. The process of claim 6, wherein the compound of formula (3) is reacted with a compound of the formula Z-Y--X--CO.sub.2H in methanol. (patentgenius.com)
  • 2. The organic electroluminescent device of claim 1 , wherein the host material and the phosphorescent compound have a T 1 value of 60 kcal/mol or higher, and the phosphorescent compound emits phosphorescence having a peak wavelength of 550 nm or shorter. (google.com)
  • 3. The organic electroluminescent device of claim 1 , wherein the at least one organic compound layer is at least three organic compound layers including a hole transporting layer, a light emitting layer, and an electron transporting layer, and the electron transporting layer has an IP value of 5.9 eV or higher. (google.com)
  • The organic electroluminescent device of claim 1 , wherein the phosphorescent compound concentration in the light emitting layer is 0.1 to 50% by weight. (google.com)
  • 1. A negative-working presensitized plate useful for preparing a lithographic printing plate having a negative-working photosensitive layer on an aluminum substrate, which comprises an intermediate layer comprising a compound having one diazonium group and a molecular weight of 1000 or less formed between said photosensitive layer and said aluminum substrate. (google.com.au)
  • 5. The negative-working presensitized plate according to claim 1 , wherein the intermediate layer comprises the diazonium compound in an amount ranging from 30 to 100% by weight on the basis of the total weight of the intermediate layer. (google.com.au)
  • cyclizing a compound of the formula (3): ##STR00070## wherein R.sup.1, R.sup.2, X, Y, and Z are asdefined above. (patentgenius.com)
  • 2. The process of claim 1, wherein the compound of formula (3) is cyclized in an inert solvent in the presence of a base. (patentgenius.com)
  • 9. The process of claim 6, wherein the compound of formula (3) is reacted with a compound of the formula Z-Y--X--C(O)Cl. (patentgenius.com)
  • 3 . The light-emitting device according to claim 1 , wherein the compound having a transition metal atom-phosphorus atom bond is a compound having a maximum emitted wavelength, λmax, in a range of 350 nm to 550 nm. (google.co.uk)
  • 11 . The light-emitting device according to claim 5 , wherein the compound represented by the formula (4) has a maximum emitted wavelength, λmax, in a range of 350 nm to 550 nm. (google.co.uk)
  • 14 . The light-emitting device according to claim 5 , wherein the layer comprising the compound represented by the formula (4) is a layer formed by a coating process. (google.co.uk)
  • As a compound having SI Pi agonist activity, an indane derivative represented by the following formula has been known (Patent Document 2). (allindianpatents.com)
  • As a compound having SIPi agonist activity, an oxadiazole derivative represented as follows has been known (following figure, Patent Documents 3, 4, 5, and 6). (allindianpatents.com)
  • the compound is further comprised of M as a hydroxonium, a nitrosonium NO + , an ammonium -NH 4 + , a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. (google.com)
  • Diethanolamine, often abbreviated as DEA or DEOA, is an organic compound with the formula HN(CH2CH2OH)2. (chemchart.com)
  • SUBSTANCE: invention relates to a compound, which is N3-1H-indol-5-yl-5-pyridin-4-ylpyrazine-2,3-diamine, or a pharmaceutically acceptable salt thereof, which can act as inhibitors of protein kinase, especially FLT3 tyrosine kinase. (russianpatents.com)
  • Sphingosine-1 -phosphate is a metabolite of sphingolipid which is a physiologically active substance secreted from an activated platelet (Non-Patent Document 1). (allindianpatents.com)
  • The sphingosine-1-phosphate receptor is a G protein-binding type, and belongs to an Edg-family which is the endothelial differentiation gene. (allindianpatents.com)
  • Many receptors bind to G proteins by stimulation of sphingosine-1-phosphate. (allindianpatents.com)
  • It has been known that by the stimulating action of S1P1 of sphingosine-1 -phosphate, migration of lymphocyte, inhibition of apoptosis, generation of cytokine, sequestering lymphocyte in thymus and other secondary lymphoid tissues are induced, and angioplasty in vascular endothelial cell is promoted (Non-Patent Document 2). (allindianpatents.com)
  • On the other hand, expression of S1P3 is also found on cardiomyocyte, and transiently-decrease in heart rate (infrequent pulse) or in blood pressure by stimulation of sphingosine-1 -phosphate is observed (Non-Patent Document 3) while infrequent pulse is not observed by stimulation of sphingosine-1-phosphate in a knockout mouse wherein SIP3 is genetically deleted (Non-Patent Document 4). (allindianpatents.com)
  • It has been reported that FTY720 phosphate ester which is an active body of FTY720 currently in a clinical trial has non¬ selective agonist activity for SIPi, S1P3, S1P4 and S1P5 (Non-Patent Document 5), and especially infrequent pulse induced by the stimulation effect through SIP3 is frequently expressed as an undesirable side effect in clinical trial (Non-Patent Document 6). (allindianpatents.com)
  • Accordingly, it is considered that for sequestering lymphocyte through a sphingosine-1 - phosphate receptor, the stimulation from SI Pi is essential (Non-Patent Document 7), while the stimulation from SIP3 is not essential which is rather considered to be related to the induction of undesirable side effect. (allindianpatents.com)
  • The Janus kinase (JAK) family of tyrosine kinases (JAK l, 2, 3, and Thy 1) is activated by interaction with other proteins (see O'shea, J.J. et al. (russianpatents.com)