5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole
Vinyl Chloride
Nitro Compounds
FANFT
Guanylate Cyclase
Nitric Oxide Donors
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
Molecular Structure
Structure-Activity Relationship
Receptor, Adenosine A2A
Cyclic GMP
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Magnetic Resonance Spectroscopy
Amino Acids
Adenosine A2 Receptor Antagonists
Antifungal Agents
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Nitroblue Tetrazolium
Adenosine A2 Receptor Agonists
Furylfuramide
Purinergic P1 Receptor Antagonists
Enzyme Inhibitors
Polyvinyl Chloride
Receptors, Purinergic P1
Triazines
Sequence Homology, Amino Acid
Polyvinyl Alcohol
Antimutagenic Agents
Ferula
Phenethylamines
Adenosine-5'-(N-ethylcarboxamide)
Pyelitis
Trinitrotoluene
Adenosine
Carcinogens
Thermolysin
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Hemangiosarcoma
Furans
Cloning, Molecular
Receptor, Adenosine A1
Urinary Bladder
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).