5-alpha Reductase Inhibitors: Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.Finasteride: An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.Urinary Retention: Inability to empty the URINARY BLADDER with voiding (URINATION).Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.3-Oxo-5-alpha-Steroid 4-Dehydrogenase: An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.Cholestenone 5 alpha-Reductase: An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.Hydroxymethylglutaryl-CoA Reductase Inhibitors: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.Oxidoreductases Acting on CH-CH Group Donors: A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds.Aldehyde Reductase: An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.Pravastatin: An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).Hydroxymethylglutaryl CoA Reductases: Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.RhodanineHeptanoic Acids: 7-carbon saturated monocarboxylic acids.Ribonucleotide ReductasesImidazolidines: Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.Mevalonic AcidNitrate Reductases: Oxidoreductases that are specific for the reduction of NITRATES.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Fatty Acids, Monounsaturated: Fatty acids which are unsaturated in only one position.Sorbitol: A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.Sugar Alcohol Dehydrogenases: Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.Glutathione Reductase: Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.Cytochrome-B(5) Reductase: A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.Nitrite Reductases: A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (Enzyme Nomenclature, 1992) EC 1.FluorobenzenesOxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)FMN Reductase: An enzyme that utilizes NADH or NADPH to reduce FLAVINS. It is involved in a number of biological processes that require reduced flavin for their functions such as bacterial bioluminescence. Formerly listed as EC 1.6.8.1 and EC 1.5.1.29.Thioredoxin-Disulfide Reductase: A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5Anticholesteremic Agents: Substances used to lower plasma CHOLESTEROL levels.NADPH-Ferrihemoprotein Reductase: A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.Alopecia: Absence of hair from areas where it is normally present.Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.HerbalsHerbals as Topic: Works about books, articles or other publications on herbs or plants describing their medicinal value.Urothelium: The epithelial lining of the URINARY TRACT.Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.RomeSicilyEncyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.Aqueous Humor: The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)Pregnanolone: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.Allosteric Regulation: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.Anticonvulsants: Drugs used to prevent SEIZURES or reduce their severity.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Rosmarinus: A plant genus of the LAMIACEAE family. It is known as a spice and medicinal plant.Diterpenes, Abietane: A group of DITERPENES cyclized into 3-ring PHENANTHRENES.Salvia: A genus in the mint family (LAMIACEAE).

Mutagenicity tests on epristeride in vitro and in vivo. (1/197)

AIM: To evaluate the genetic effects of epristeride (Epr), a new prospective drug for treating benign prostatic hyperplasia. METHODS: 1) Assaying reverse mutation in histidine nutritional deficiency strain of Salmonella typhimurium 2) detecting chromosome aberrations in Chinese hamster lung cells (CHL); 3) micronucleus assays of mouse bone marrow; 4) counting sperm shape abnormalities 35 d after first ig Epr. RESULTS: 1) The reverse mutation happened at almost the same rate of the negative control. Epr did not induce bacterial mutation. 2) In vitro, the rates of aberration were all below 3%, thus Epr did not induce chromosome damage in CHL. 3) Micronucleated polychromatic erythroblasts (PCE) were not apparently more than those of sovent control, Epr did not induce the formation of micronuclei in PCE. 4) With Epr 818, 682, and 341 mg.kg-1, the head abnormalities of sperms were 5.3% +/- 2.7%, 5.3% +/- 1.9%, and 5.2% +/- 1.2%, respectively. CONCLUSION: No genetic toxicity of Epr was detected.  (+info)

Z-350, a novel compound with alpha 1-adrenoceptor antagonistic and steroid 5 alpha-reductase inhibitory actions: pharmacological properties in vivo. (2/197)

The alpha(1)-adrenoceptor-antagonistic and steroid 5alpha-reductase-inhibitory actions of Z-350 [(S)-4-{3-{4-{1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazine-1-y l]propoxy}benzoyl}indole-1-yl}butyric acid hydrochloride] were investigated in rabbits and rats in vivo. Z-350 (1-30 mg/kg), administered intraduodenally, dose-dependently inhibited phenylephrine-induced increases in prostatic urethral pressure with an ED(50) value of 3.8 mg/kg in anesthetized male rabbits, whereas the effects on mean blood pressure and orthostatic hypotensive response were weaker when compared with other alpha(1)-adrenoceptor antagonists, tamsulosin and prazosin. Z-350 (1-10 mg/kg p.o.) dose-dependently inhibited the prostatic steroid 5alpha-reductase activity in rats with an ED(50) value of 2.8 mg/kg. The daily oral administration of Z-350, at >==10 mg/kg for 7 days, significantly reduced the prostatic growth induced by testosterone in castrated rats, with no effect on dihydrotestosterone-induced prostatic growth. These results indicate that Z-350 exhibited alpha(1)-adrenoceptor-antagonistic and 5alpha-reductase inhibitory actions at almost equal doses in vivo, and was expected to improve the bladder outlet obstruction associated with benign prostatic hyperplasia with smaller cardiovascular adverse effect.  (+info)

Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor. (3/197)

The Endocrine Disrupter Screening and Testing Advisory Committee has recommended the female pubertal onset assay as a Tier I test to detect potential endocrine-disrupting chemicals (EDs). We evaluated this assay's ability to detect EDs acting through various mechanisms. In two similar experiments, weanling female rats were dosed for 20 days by gavage with vehicle (0.5% methocel) or the following test compounds (mg/kg/day): 17beta-estradiol (E2; 0.1, 2, or 4), ketoconazole (KETO; 24, 50, or 100), finasteride (FIN; 20), testolactone (TL; 220), fadrozole (FAD; 0.6, 1.2, or 6.0) or 6-propylthiouracil (PTU; 240). In vehicle-treated females, mean age at pubertal onset, as evidenced by vaginal opening (VO), varied interexperimentally from 32.3+/-1.6 days to 33.5+/-1.8 days. At 0.1 mg/kg E2, age at VO was reduced slightly to 31.0+/-1.6 days, but not significantly (alpha=0.05). Higher E2 doses (2.0 and 4.0) reduced age at VO to 28 days. KETO delayed VO, but this delay was significant only at 100 mg/kg (39.7+/-2.4 days). FIN and TL had no effect on age at pubertal onset; however, FAD significantly delayed VO. PTU delayed VO to 34.2+/-1.1 days and altered thyroid weight, histology, and hormone levels. With each compound, significant changes in age at VO were accompanied by decreased uterine or ovarian weights. Thus, although this assay did not detect TL or lower doses of E2 (0.1 mg/kg) or KETO (< or = 50 mg/kg), it was capable of detecting EDs operating through a variety of mechanisms.  (+info)

Steroid 5alpha-reductase inhibitory activity and hair regrowth effects of an extract from Boehmeria nipononivea. (4/197)

The acetone extract of Boehmeria nipononivea showed both potent 5alpha-reductase inhibitory activity and hair regrowth promotion effects on mice. 5alpha-Reductase inhibitory activity-guided fractionation led to six active fatty acids: alpha-linolenic, linoleic, palmitic, elaidic, oleic and stearic acids. The extract of B. nipononivea, and alphalinolenic, elaidic and stearic acids exhibited a hair regrowth effect.  (+info)

Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis. (5/197)

17-(5'-Isoxazolyl)androsta-4,16-dien-3-one (L-39), a novel androstene derivative, was synthesized and evaluated in vitro and in vivo. L-39 showed potent and non-competitive inhibition of human testicular microsomal 17alpha-hydroxylase/C(17,20)-lyase with an IC50 value of 59 nM and Ki of 22 nM. L-39 also showed potent and competitive inhibition of 5alpha-reductase in human prostatic microsomes with IC50 and Ki values of 33 and 28 nM respectively. L-39 (5 microM) has also been shown to manifest anti-androgenic activity in cultures of human prostate cancer cell lines (LNCaP) by preventing the labelled synthetic androgen R1881 (5 nM) from binding to the androgen receptors. Androgen-dependent human prostate cancer xenografts (PC-82) were grown in nude mice and the effects of L-39 (50 mg kg(-1) day(-1)) on tumour growth and prostate-specific antigen (PSA) levels were determined after 28 days. L-39 significantly (P < 0.01) diminished tumour growth and wet weights to a similar extent as castration or flutamide treatment. L-39 also significantly (P < 0.01) reduced serum PSA levels by more than 80% in the mice bearing human prostate cancer xenografts. Pharmacokinetic studies were also conducted in male Balb/c mice. After subcutaneous administration of a single bolus dose, L-39 was rapidly absorbed into the systemic circulation. Peak plasma levels occurred at 0.75 h and then declined with a t(1/2) of 1.51 h. The bioavailability of L-39 after subcutaneous administration was 28.5%. These results demonstrate that L-39 is a potent inhibitor of androgen synthesis and is effective in reducing the growth of human prostate cancer xenografts in nude mice. Although improvements in the bioavailability are necessary, L-39 is a potential lead compound with this profile as an inhibitor of prostate cancer growth.  (+info)

Effects of a new steroidal aromatase inhibitor, TZA-2237, and/or chlormadinone acetate on hormone-induced and spontaneous canine benign prostatic hyperplasia. (6/197)

OBJECTIVE: It has been known for many years that human benign prostatic hyperplasia (BPH) is composed predominantly of hyperplastic stromal cells rather than epithelial cells. In the present study the effects of a new steroidal aromatase inhibitor on hormone-induced and spontaneous canine BPH were investigated. METHODS: (1) Effects of TZA-2237 on hormone-induced canine BPH. Ten castrated beagles were administered testosterone and androstenedione 6 days/week for 8 months, and divided randomly into three groups after 2 months of treatment as follows. Group I served as controls, Group II was given 0.5 and Group III was given 2.5 mg/kg/day TZA-2237 5 days/week for 6 months. (2) Effects of TZA-2237 on spontaneous canine BPH. Twenty aged beagles with BPH were divided into five groups, Group IV was untreated, Group V was treated with 1 and Group VI with 5mg/kg/day TZA-2237 5 days/week for 31 weeks. Group VII was treated with 5mg/kg/day Atamestane and Group VIII was treated with 0.3 mg/kg/day chlormadinone acetate (CMA) 5 days/week. (3) Effects of TZA-2237 combined with CMA on spontaneous canine BPH. Three aged beagles with BPH were treated with 1mg/kg/day TZA-2237 and 0.03 mg/kg/day CMA 5 days/week for 20 weeks (Group IX) and a further three aged beagles with BPH were treated with 0.3 mg/kg/day CMA alone 5 days/week (Group X). RESULTS: Hormone-induced prostatic growth was significantly suppressed in group III compared with that in other groups. In Group III, the intraprostatic aromatase activity, estradiol level and androgen receptor content decreased significantly in comparison with the values in Group I. The prostatic weights in Groups V, VI and VII increased significantly in comparison with the weight in Group IV. Serum LH and testosterone levels in Groups V, VI, and VII increased significantly in comparison with the level in Group IV. The prostatic weight in Group IX was decreased only slightly, but the smooth muscle component was decreased significantly. CONCLUSIONS: TZA-2237 is a new, unique and effective aromatase inhibitor that causes inhibition of both epithelial and stromal compartments in hormone-induced canine BPH. Dual inhibition of androgen and estrogen resulted in inhibition of smooth muscle growth, and should prove effective as a new method of treatment given the atrophic effects on not only the epithelium but also the stroma in human BPH.  (+info)

Increased levels of clusterin (SGP-2) mRNA and protein accompany rat ventral prostate involution following finasteride treatment. (7/197)

Finasteride is a well-known inhibitor of the prostatic enzyme 5 alpha-reductase type 2 which prevents conversion of testosterone into 5 alpha-dihydrotestosterone, the active intraprostatic androgen, which causes prostate involution through a combination of cell atrophy and cell death. The drug is widely used to improve symptoms of benign prostatic hyperplasia in man. Clusterin, a glycoprotein which is generally up-regulated under conditions inducing cell atrophy or organ involution, is produced at a high level in the regressing rat ventral prostate following androgen ablation. According to several authors, clusterin does not respond to finasteride treatment, suggesting a different action of testosterone and 5 alpha-dihydrotestosterone. We show here that, under our conditions, finasteride was capable of inducing production of both clusterin mRNA and protein in the rat ventral prostate. In fact, by using different and converging techniques, such as Northern hybridization, in situ hybridization histochemistry and immunohistochemistry, we were able to show a strong induction of the clusterin gene in the epithelial cell population of the gland. The response to finasteride, which was similar to that seen with castration, occurred with a delay of a few days. In situ and immunohistochemistry experiments indicated that both orchidectomy and finasteride administration resulted in increased transition of the epithelial cells from the columnar to the cuboidal (atrophic) shape, and this was accompanied by an increased intensity of the signal for clusterin. Thus, it appears that induction of clusterin is part of the molecular process leading to prostate involution caused by either orchidectomy or finasteride administration.  (+info)

Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer. (8/197)

We have found that in addition to being potent inhibitors of 17alpha-hydroxylase/C17,20-lyase and/or 5alpha-reductase, some of our novel androgen synthesis inhibitors also interact with the mutated androgen receptor (AR) expressed in LNCaP prostate cancer cells and the wild-type AR expressed in hormone-dependent prostatic carcinomas. The effects of these compounds on the proliferation of hormone-dependent human prostatic cancer cells were determined in vitro and in vivo. L-2 and L-10 are delta4-3-one-pregnane derivatives. L-35 and L-37 are delta5-3beta-ol-androstane derivatives, and L-36 and L-39 are delta4-3-one-androstane-derived compounds. L-2, L-10, and L-36 (L-36 at low concentrations) stimulated the growth of LNCaP cells, indicating that they were interacting agonistically with the mutated AR expressed in LNCaP cells. L-35, L-37, and L-39 acted as LNCaP AR antagonists. To determine whether the growth modulatory effects of our novel compounds were specific for the mutated LNCaP AR, competitive binding studies were performed with LNCaP cells and PC-3 cells stably transfected with the wild-type AR (designated PC-3AR). Regardless of AR receptor type, all of our novel compounds were effective at preventing binding of the synthetic androgen methyl-trienolone[17alpha-methyl-(3H)-R1881 to both the LNCaP AR and the wildtype AR. L-36, L-37, and L-39 (5.0 microM) prevented binding by >90%, whereas L-35 inhibited binding by 30%. To determine whether the compounds were acting as agonists or antagonists, LNCaP cells and PC-3AR cells were transfected with the pMAMneoLUC reporter gene. When luciferase activity was induced by dihydrotestosterone, all of the compounds were found to be potent inhibitors of transcriptional activity, and the pattern of inhibition was similar for both receptor types. However, L-2, L-10, and L-36 were determined to be AR agonists, and L-35, L-37, and L-39 were wild-type AR antagonists. When tested in vivo, L-39 was the only AR antagonist that proved to be effective at inhibiting the growth of LNCaP prostate tumor growth. L-39 slowed tumor growth rate in LNCaP tumors grown in male SCID mice to the same level as orchidectomy, significantly reduced tumor weights (P < 0.05), significantly lowered serum levels of prostate-specific antigen (P < 0.02), and significanty lowered serum levels of testosterone (P < 0.05). L-39 also proved to be effective when tested against the PC-82 prostate cancer xenograft that expresses wild-type AR. These results show that some of our compounds initially developed to be inhibitors of androgen synthesis also interact with the human AR and modulate the proliferation of hormone-dependent prostatic cancer cells. Therefore, compounds such as L-39, which have multifunctional activities, hold promise for the treatment of androgen-dependent prostate tumors.  (+info)

Dr. Marc Garnick discusses prostate cancer chemoprevention with the use of the 5 Alpha Reductase inhibitors finasteride and dutasteride.
Anti-androgen can be used in the treatment of benign prostatic hyperplasia, acne, hirsutism, and androgenic alopecia. For the search of anti-androgenic activity through steroid 5-alpha reductase...
Saw palmetto extract (SPE), used widely for the treatment of benign prostatic hyperplasia (BPH) has been shown to bind alpha(1)-adrenergic, muscarinic and 1,4-dihydropyridine (1,4-DHP) calcium channel antagonist receptors. Major constituents of SPE are lauric acid, oleic acid, myristic acid, palmiti …
ABSTRACTIntroductionBenign prostatic hyperplasia (BPH) is a common problem affecting middle-aged and elderly men. First-line medical therapy includes α 1blockers and 5α-reductase inhibitors (5ARIs), such as finasteride and dutasteride. 5ARI use has been associated with adverse sexual outcomes, inclu
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12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity. - Mechanism of Action & Protocol.
Antonio L. PASTORE 1, 2 ✉, Andrea FUSCHI 1, 2, Cosimo DE NUNZIO 3, Matteo BALZARRO 4, Yazan AL SALHI 1, 2, Gennaro VELOTTI 1, 2, Alessia MARTOCCIA 1, 2, Lorenzo CAPONE 1, 2, Nelia AMIGONI 4, Mario FALSAPERLA 5, Consalvo MATTIA 6, Walter ARTIBANI 4, Andrea TUBARO 3, Antonio CARBONE 1, 2. 1 Urology Unit, Department of Medico- Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy; 2 Uroresearch, no profit Association for Research in Urology, Latina, Italy; 3 Department of Urology, SantAndrea Hospital Rome, Sapienza University of Rome, Rome, Italy; 4 Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy; 5 Department of Urology, Vittorio Emanuele Hospital, Catania Italy; 6 Anesthesiology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy. ...
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Clinical Trials - clinicaltrials.gov The enzyme 5-alpha reductase is present in small amounts in muscle and converts testosterone to dihydrotestosterone (DHT). ...
CO Finasteride: Finasteride belongs to a group of medications known as 5-alpha-reductase inhibitors. Finasteride is used to treat benign prostatic hyperplasia (BPH), also known as enlarged prostate. Finasteride can be used alone or in combination with another medication called doxazosin (an alpha blocker). These medications may be taken together to reduce the progress of your BPH symptoms. If you are taking this combination, be sure to also read the patient information for doxazosin.
Finasteride is an FDA-approved hair loss drug that works by blocking an enzyme that would otherwise change testosterone to DHT. It has to be taken every day and may take at least three months to take effect. It can have some side effects, including sexual problems, and its worth noting that if a man stops taking finasteride, the hair he grew back will probably be lost.. Finasteride comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take finasteride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take finasteride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.. If you are taking finasteride to treat BPH, you should know that finasteride may control your condition, but will not cure it. It may take at least 6 months before your symptoms improve. Continue to take finasteride even ...
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Most common lower urinary tract symptoms in post-middle aged males are due to benign prostate enlargement. Pharmacological treatments include *alpha blockers and 5-alpha reductase inhibitors (5ARIs). 5ARIs have been shown to reduce the size of the prostate gland. 5ARIs block the transformation of testosterone into dehyrotestosterone, an attempt to prevent division of the cells in […]. View Post ...
Finasteride, a 5 alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about prostate histopathology in men taking finasteride. To determine the mechanism by which
B. Chronic administration (defined as daily or every other day for continued use greater than 14 days) of corticosteroids deemed systemic by investigator within 28 days before the first planned dose of PSA-TRICOM. Use of inhaled steroids, nasal sprays, and topical creams for small body areas is allowed.. C. Serious intercurrent medical illness that, in the judgment of the investigator, would interfere with patient s ability to carry out the treatment program.. D. History of seizure, including any febrile seizure, loss of consciousness, or transient ischemic attack, or any condition that may pre-dispose to seizure (e.g., prior stroke, brain arteriovenous malformation, head trauma with loss of consciousness requiring hospitalization).. E. Other medications used for urinary symptoms including 5-alpha reductase inhibitors (finasteride and dutasteride) and alternative medications known to alter PSA (eg phytoestrogens and saw palmetto). F. History of prior chemotherapy. G. History of prior ...
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Finasteride 5mg tab not. Camber Pharmaceuticals manufactures Finasteride, 5 mg - Propecia, Proscar Generic - with quality and integrity. A 5-alpha-reductase inhibitor for the treatment of.
Buy Fincar Online! Fincar, a 5-alpha reductase inhibitor, widely used in the medical management of male pattern hairloss, has been reported to cause sexual side effects. The bioavailability of Fincar is not related to food intake.
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FDA Q&A: 5-alpha reductase inhibitors (5-ARIs) may increase the risk of a more serious form of prostate cancer https://t.co/laGKBe1wo0 06:11:11 PM September 04, 2017 ReplyRetweetFavorite ...
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Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH. [Wikipedia]
TY - JOUR. T1 - Design of the Prostate Cancer Prevention Trial (PCPT). AU - Feigl, Polly. AU - Blumenstein, Brent. AU - Thompson, Ian. AU - Crowley, John. AU - Wolf, Michael. AU - Kramer, Barnett S.. AU - Coltman, Charles A.. AU - Brawley, Otis W.. AU - Ford, Leslie G.. PY - 1995/6. Y1 - 1995/6. N2 - The PCPT is a chemoprevention trial of finasteride with a primary endpoint of biopsyproven presence or absence of prostate cancer. A total of 18,000 healthy men, aged 55 years and older, will be randomized. Half will receive finasteride (5 mg/day) and half will receive placebo (one matching tablet per day) for 7 years. The trial is designed to have 92% power to detect a 25% reduction in period prevalence of biopsy-proven disease using a two-sided test with α = 0.05. The trial is complicated by the known impact of finasteride on the major screening test for prostate cancer, prostate specific antigen (PSA). This paper describes the PCPT design with reference to alternatives that were considered. The ...
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Prior therapy for prostate cancer [Exceptions: LHRH agonist or antagonist may have been initiated within 30 days prior to enrollment. Bicalutamide may have been given within 60 days of enrollment as long as it has been stopped at least 7 days before enrollment and total duration was no longer than 30 days. This is to allow enrollment of those who have been given bicalutamide as a bridge for LHRH agonist/antagonist. It is highly unlikely a short non-overlapping course of bicalutamide will interact with abiraterone acetate in a measurable way. Previous alpha-reductase inhibitor use allowed IF patient has not been taking for at least 30 days prior to abiraterone acetate initiation, OR if alpha reductase inhibitor was not used as a primary treatment of prostate cancer and the PSA on alpha-reductase inhibitor remains within eligibility when doubled ...
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The key aim of this Global report is to provide updates and data relating to the Benign Prostatic Hyperplasia (BPH) Drugs market and also make out all the opportunities for expansion in the market. To begin with, the report entails a market synopsis and offers market definition and outline of the Benign Prostatic Hyperplasia (BPH) Drugs market. The synopsis section comprises market dynamics entailing market restraints, drivers, trends, and opportunities trailed by pricing analysis and value chain analysis.. The report presents a demand for individual segment in each region. It demonstrates various segments Alpha-blocker, Phosphodiesterase Type-5 Inhibitors, 5-alpha-Reductase Inhibitors and sub-segments Hospitals, Clinics, Others of the global Benign Prostatic Hyperplasia (BPH) Drugs market. Further, the report provides valuable data such as offerings, revenue, and a business outline of the prominent players in the Benign Prostatic Hyperplasia (BPH) Drugs market. The Global report draws attention ...
Propecia® is produced by Merck S&D. Propecia® treats the most common type of hair loss in mencalled MPHL or MPB (male pattern baldness). It is also known as androgenetic alopecia (AGA). It affects about 50% of men over the age of 50. It is a condition, where hair follicles are being destroyed by the high levels of sex hormone dihydrotestosterone (DHT).. DHT binds to androgen receptors in susceptible hair follicles and activates genes responsible for follicular miniaturization. The active ingredient Finasteride is a type II 5-alpha reductase inhibitor and has a trichogenic activity (hair growth-promoting). It hinders the action of 5-alpha reductase enzyme, responsible for the conversion of testosterone to dihydrotestosterone (DHT). Due to inhibiting of this enzyme, Propecia® lowers scalp and serum DHT concentrations (up to 60%) and slows down the complete hair loss process.. Finasteride in higher doses (Finast®, Fincar®, Proscar®, Prosteride®) is used for the treatment and maintenance of ...
Sandoz Dutasteride: Dutasteride belongs to a class of medications known as 5-alpha-reductase inhibitors. It is used to relieve symptoms of benign prostatic hyperplasia (BPH) in men with enlarged prostates. BPH is a noncancerous enlargement of the prostate gland that usually occurs in men after the age of 50.
As Ronnie Coleman would say, "Thats like comparing apples and oranges." Clomid is a synthetic estrogen that increases testosterone levels by increasing the output of pituitary luteinizing hormone (LH). Arimidex is an aromatase inhibitor that blocks the conversion of testosterone into estrogen and in doing so prevents pituitary suppression of LH. Finasteride is a 5-alpha reductase inhibitor that blocks the conversion of testosterone into dihydrotestosterone (DHT) thus, maintaining higher blood levels of testosterone. Together, these three drugs synergistically raise testosterone levels into the highest physiological ranges possible (probably around 1,200-1,400). Injecting exogenous testosterone at a dosage of 500 milligrams per week or higher will lead to a significant pharmacological effect on the body- increased muscle mass. These pharmacological gains observed with high testosterone supplementation differ greatly from the physiological boost noted by slightly elevating natural testo. ...
Drug maker Merck & Co. currently faces more than twelve hundred lawsuits filed by men who suffered one or more adverse health effects as a result of taking Propecia. The plaintiffs accuse Merck of failing to warn patients that the sexual side effects may be permanent, continuing even after the man stopped taking the drug.. The 1 mg dose of finasteride-brand name Propecia-received Food and Drug Administration (FDA) approval in 1997 to treat male pattern baldness. At a higher dose, under the name Proscar, finasteride is prescribed for benign prostatic hyperplasia (enlarged prostate) and urinary problems. Finasteride is a 5-alpha reductase inhibitor (5-ARI). Propecias active ingredient can interfere with male hormones, including testosterone derivatives.. First Propecia Trial Expected in Fall 2017. More than a thousand lawsuits have been consolidated for pretrial proceedings in a multidistrict litigation (MDL) in the federal court in the Eastern District of New York. The first cases are expected ...
The four-year REDUCE (REduction by DUtasteride of prostate Cancer Events) clinical study evaluated prostate cancer risk reduction in men taking dutasteride, a 5-alpha-reductase inhibitor (5ARI) typically used to treat enlarged prostate. REDUCE results showed that dutasteride decreased the risk of biopsy detectable prostate cancer by 22.8 percent compared to a placebo group, but concerns remained about the drugseffectiveness.
Traditionally, men with uncomplicated benign prostatic hyperplasia have been managed with prostatectomy or "watchful waiting." Recently, less invasive treatments, including balloon dilation, α-blockers, and finasteride, have been used in everyday practice. These treatments appear to be less effective than prostatectomy, but patients may prefer them because they have fewer adverse effects. Unfortunately, few well-designed trials have been available to guide selection among these options. Gormley and colleagues are to be congratulated for doing the largest clinical trial of a benign prostatic hyperplasia treatment. Finasteride, a 5-α reductase inhibitor, moderately reduced prostate size over 1 year. The absolute improvements in peak urinary flow and symptom score were, however, relatively small. The overall consistency of the results mitigate methodologic concerns about the multiple statistical comparisons made. The message for clinicians is not so clear. The data presented do not allow an ...
Abstract: Benign prostatic hyperplasia (BPH) affects the aging male. Treatment options vary widely. Some men will elect to conservatively monitor their symptoms and make alterations to their lifestyle choices. Pharmacotherapy options exist as well, and include alpha-blockers, 5-alpha reductase inhibitors and phosphodiesterase-5 inhibitors. Lastly, surgical options are also a viable treatment option, with many types at the disposal of the caregiver. Technological advancements have changed, and will continue to change the field in the near future. This review outlines the important aspects of this common affliction ...
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Avodart (dustasteride) for prostatitis is a 5 alpha reductase inhibitor that is sometimes prescribed for men with urinary symptoms and pain with prostatitis
... (INN (former developmental code name FCE-24,928) is a steroidal aromatase inhibitor which was under development by ... Unlike other steroidal aromatase inhibitors such as formestane and exemestane, minamestane does not have androgenic properties ... Combs, Donald W (1995). "Review Oncologic, Endocrine & Metabolic: Recent developments in aromatase inhibitors". Expert Opinion ... June 1994). "Novel aromatase and 5 alpha-reductase inhibitors". The Journal of Steroid Biochemistry and Molecular Biology. 49 ( ...
In long-term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention (−57% at 4 years) and ... Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M (February 2010). "An overview on 5alpha-reductase inhibitors". Steroids. ... 402-. ISBN 978-0-323-08619-6. Robaire B, Henderson NA (May 2006). "Actions of 5alpha-reductase inhibitors on the epididymis". ... "A new look at the 5alpha-reductase inhibitor finasteride". CNS Drug Reviews. 12 (1): 53-76. doi:10.1111/j.1527-3458.2006.00053. ...
Reductase Inhibitor". Current Topics in Medicinal Chemistry. 6 (5): 405-21. doi:10.2174/156802606776743101. PMID 16719800. ... "An overview on 5alpha-reductase inhibitors". Steroids. 75 (2): 109-53. doi:10.1016/j.steroids.2009.10.005. PMID 19879888. Wu C ... It is a competitive, mechanism-based (irreversible) inhibitor of all three isoforms of 5α-reductase, types I, II, and III (IC50 ... which is similarly an irreversible inhibitor of 5α-reductase but only inhibits the type II and III isoenzymes. As a result of ...
This is done through alpha antagonists such as tamsulosin or 5-alpha-reductase inhibitors such as finasteride and dutasteride. ... 50 (5): 969-79; discussion 980. doi:10.1016/j.eururo.2005.12.042. PMID 16469429. Ö L Özdal, C Özden, K Benli, S Gökkaya, S ... doi:10.1038/sj.pcan.4500818; published online 5 July 2005 pubmed 15999118 http://www.nature.com/pcan/journal/v8/n3/full/ ...
... tumour necrosis factor alpha, and interleukin-1 in modulating progesterone and oestradiol production by human luteinized ... encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase ... 5-alpha reductase inhibitors (such as finasteride and dutasteride) may also be used; they work by blocking the conversion of ... In PCOS, there is a so-called "follicular arrest"; i.e., several follicles develop to a size of 5-7 mm, but not further. No ...
A substance known as torilin can be extracted from the plant and has been shown to be a potent inhibitor of 5 alpha-reductase, ... Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. Planta Med. 2003 May;69(5):459-61. PMID ...
Flores E, Bratoeff E, Cabeza M, Ramirez E, Quiroz A, Heuze I (May 2003). "Steroid 5alpha-reductase inhibitors". Mini-Reviews in ... Dörsam J, Altwein J (2009). "5alpha-Reductase inhibitor treatment of prostatic diseases: background and practical implications ... Androgen synthesis inhibitors are enzyme inhibitors that prevent the biosynthesis of androgens. This process occurs mainly in ... Examples include the CYP17A1 inhibitors ketoconazole, abiraterone acetate, and seviteronel, the CYP11A1 (P450scc) inhibitor ...
Flores E, Bratoeff E, Cabeza M, Ramirez E, Quiroz A, Heuze I (May 2003). "Steroid 5alpha-reductase inhibitors". Mini-Reviews in ... Androgen synthesis inhibitorsEdit. Androgen synthesis inhibitors are enzyme inhibitors that prevent the biosynthesis of ... Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M (2010). "An overview on 5alpha-reductase inhibitors". Steroids. 75 (2): ... Dörsam J, Altwein J (2009). "5alpha-Reductase inhibitor treatment of prostatic diseases: background and practical implications ...
Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients". J ... such as alpha-1 receptor blockers, 5-alpha-reductase inhibitors, or phosphodiesterase-5 enzyme inhibitors.Those with severe/ ... 74 (5): 542-550. CS1 maint: Explicit use of et al. (link) Traish, AM; Hassani, J; Guay, AT; et al. (2011). "Adverse Side ... 40 (5): 655-663. doi:10.1007/s00270-016-1539-3. Assis, AM; Rodrigues, VCP; Yoshinaga, EM; et al. (2015). "Prostatic artery ...
Zaccheo T, Giudici D, di Salle E (June 1998). "Effect of early treatment of prostate cancer with the 5alpha-reductase inhibitor ... Turosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-reductase which was under investigation by GlaxoSmithKline ... Seiffert K, Seltmann H, Fritsch M, Zouboulis CC (February 2007). "Inhibition of 5alpha-reductase activity in SZ95 sebocytes and ... a comparative study of selective inhibitors". The Journal of Steroid Biochemistry and Molecular Biology. 54 (5-6): 273-9. doi: ...
... therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5alpha-reductase inhibitor ... Effects may take longer to appear than alpha blockers, but they persist for many years. When used together with alpha blockers ... Alpha blockers relax smooth muscle in the prostate and the bladder neck, thus decreasing the blockage of urine flow. Common ... Non-selective alpha blockers such as terazosin and doxazosin may also require slow dose adjustments as they can lower blood ...
Habib FK, Ross M, Bayne CW, Bollina P, Grigor K, Chapman K (May 2003). "The loss of 5alpha-reductase type I and type II mRNA ... alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)". Yang L, Fox SA, Kirby JL, Troan BV, Hinton BT (Apr ... nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1". Proceedings of the National Academy of Sciences of the ... Ha SJ, Kim JS, Myung JW, Lee HJ, Kim JW (Apr 2003). "Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 ...
... has been found to inhibit rat and human 5α-reductase with half-maximal inhibitory concentrations (IC50) of 15 and 16 ... FCE-28260 is an azasteroidal 5α-reductase inhibitor which was developed for the treatment of benign prostatic hyperplasia and ... a new 5 alpha-reductase inhibitor: In vitro and in vivo effects". The Journal of Steroid Biochemistry and Molecular Biology. 58 ... 3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide", published 1997-07-09 .. ...
"Five-alpha-reductase Inhibitors for prostate cancer prevention". The Cochrane Database of Systematic Reviews (2): CD007091. doi ... Aspirin has been found to reduce the risk of death from cancer by about 7%. COX-2 inhibitors may decrease the rate of polyp ... Angiogenesis inhibitors were once incorrectly thought to have potential as a "silver bullet" treatment applicable to many types ... Angiogenesis inhibitors and other cancer therapeutics are used in combination to reduce cancer morbidity and mortality. ...
"Five-alpha-reductase Inhibitors for prostate cancer prevention". Cochrane Database Syst Rev (2): CD007091. doi:10.1002/14651858 ... Aspirin has been found to reduce the risk of death from cancer by about 7%. COX-2 inhibitor may decrease the rate of polyp ... "Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic ... 132 (5): 1740-5. doi:10.1053/j.gastro.2007.03.044. PMID 17484871. Zheng W, Lee SA (2009). "Well-done meat intake, heterocyclic ...
5 alpha-dihydrocortisol, an enzyme inhibited by 5-alpha reductase inhibitors, may be involved in production of aqueous humour. ... "5 alpha-dihydrocortisol in human aqueous humour and metabolism of cortisol by human lenses in vitro". Investigative ...
... selective inhibitor of the human type 1 5alpha-reductase". J. Steroid Biochem. Mol. Biol. 58 (4): 377-84. PMID 8903421. Bentham ... an inhibitor of 5alpha-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting ... It is a 4-azasteroid and a potent and selective inhibitor of 5α-reductase type I and shows high selectivity for inhibition of ... 67-. Machetti, Fabrizio; Guarna, Antonio (2005). "Novel inhibitors of 5α-reductase". Expert Opinion on Therapeutic Patents. 12 ...
The treatment of hyperplasia would consist upon which; in the case of benign prostate hyperplasia the combination of alpha-1- ... receptor blockers and 5-alpha-reductase inhibitors are effective. List of biological development disorders "Prostate ...
Some individuals do not produce any pre-ejaculate fluid, while others emit as much as 5 ml (0.18 imp fl oz; 0.17 US fl oz). Pre ... 28 (3): 374-5. doi:10.2164/jandrol.107.002576. PMID 17251594. Chughtai B, Sawas A, O'Malley RL, Naik RR, Ali Khan S, Pentyala S ... 28 (3): 374-5. doi:10.2164/jandrol.107.002576. PMID 17251594. "Researchers find no sperm in pre-ejaculate fluid". Contraceptive ... A few case reports have indicated satisfactory results when such individuals are treated with a 5-alpha-reductase inhibitor. ...
Main article: Alpha blocker. Tamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A ... When alpha 1 receptors in the bladder neck and the prostate are blocked, this causes a relaxation in smooth muscle and ... Tamsulosin, and other medications in the class called alpha blockers, work by relaxing bladder neck muscles and muscle fibers ... Selective action of tamsulosin in alpha 1A/D receptors is controversial and over three quarters of tamsulosin registered human ...
BPH may respond to alpha blocker and 5-alpha-reductase inhibitor therapy, or surgically with prostatectomy or transurethral ... 2010-02-10 Fisher, Euan; Subramonian, Kesavapillai; Omar, Muhammad Imran (2014-06-10). "The role of alpha blockers prior to ... Medications: Anticholinergics and medications with anticholinergic properties, alpha-adrenergic agonists, opiates, nonsteroidal ... resection of the prostate (TURP). Use of alpha-blockers can provide relief of urinary retention following de-catheterization ...
2012;67(5):955-61. Banka N, Mubki T, Bunagan MJ, Mcelwee K, Shapiro J. Frontal fibrosing alopecia: a retrospective clinical ... 5-alpha-reductase inhibitors. In one study, the use of anti-androgens (finasteride or dutasteride) was associated with ...
... brand names Ell-Cranell Alpha, Pantostin) is a topical 5-ARI used to treat pattern hair loss in Europe.[17][18] An extract of ... Reductase Inhibitor Finasteride". CNS Drug Reviews. 12 (1): 53-76. doi:10.1111/j.1527-3458.2006.00053.x. PMID 16834758.. ... "A new look at the 5alpha-reductase inhibitor finasteride". CNS Drug Reviews. 12 (1): 53-76. doi:10.1111/j.1527-3458.2006.00053. ... Neurosteroidogenesis inhibitor. References[edit]. *^ a b Ulrike Blume-Peytavi; David A. Whiting; Ralph M. Trüeb (26 June 2008 ...
... alpha-adrenergic blockers or 5-alpha reductase inhibitors), surgical approaches, or other herbs/supplements such as saw ...
The epidemiology is not clear; 20% of men in their 60s and 30% of men in their 70s have low testosterone; around 5% of men ... link) Basaria, S (5 April 2014). "Male hypogonadism". Lancet. 383 (9924): 1250-63. doi:10.1016/s0140-6736(13)61126-5. PMID ... Retrieved 5 March 2015. . NEJM Perspective piece: Nguyen, CP; et al. (20 August 2015). "Testosterone and "Age-Related ... 5 (5): 190-200. doi:10.1177/2042098614548680. PMC 4212439 . PMID 25360240 - via PubMed Central. Gabrielsen, JS; Najari, BB; ...
Zheng CJ, Sohn MJ, Kim WG (2006). "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of ... S. pneumoniae can be differentiated from the viridans streptococci, some of which are also alpha-hemolytic, using an optochin ... Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, alpha-hemolytic (under aerobic conditions) or beta-hemolytic ( ... Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase, ( ...
... alpha reductase inhibitors- 5-alpha reductase inhibitors are a type of medication that can help decrease the size of the ... Alpha blockers - Alpha blockers are characterized by their ability to help muscles relax. The benefit of alpha blockers is that ... Men who take alpha blockers may experience retrograde ejaculation, a condition that occurs when semen backs up into the bladder ... Alpha blockers can cause a variety of side effects, including headache, weight gain, and irregular or "pounding" heartbeat. ...
Shin TJ, Kim CI, Park CH, et al; alpha-blocker monotherapy and alpha-blocker plus 5-alpha-reductase inhibitor combination ... An alpha-blokcer should be offered before removal of the catheter.[8] ... In most cases, an alpha-blocker is prescribed before commencing TWOC and significantly increases the chance of success. ... It is a reasonably common emergency with an incidence of primary AUR in England of approximately 3/1,000 men per annum.[5]It is ...
For the search of anti-androgenic activity through steroid 5-alpha reductase... ... Seo EK, Kim KH, Kim MK, Cho MH, Choi E, Kim K, Mar W (2002) Inhibitors of 5alpha -reductase type I in LNCaP cells from the ... Cilotti A, Danza G, Serio M (2001) Clinical application of 5alpha-reductase inhibitors. J Endocrinol Invest 24(3):199-203 ... Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML (2011) Adverse side effects of 5alpha-reductase inhibitors therapy: ...
Marc Garnick discusses prostate cancer chemoprevention with the use of the 5 Alpha Reductase inhibitors finasteride and ... When I think back several decades ago when five alpha reductase inhibitors were first introduced, there was a lot of promise ... but in essence comparable studies in terms of assessing whether or not the use of a five alpha reductase inhibitor was going to ... with the inference being that these cancers that are induced by five alpha reductase inhibitors may actually be very, very ...
Aromatase · Lipoxygenase · Monoamine oxidase · COX-2 · Xanthine oxidase · Dihydrofolate reductase · Ribonucleotide reductase · ... a b Liu J, Kurashiki K, Shimizu K, Kondo R (February 2006). "5alpha-reductase inhibitory effect of triterpenoids isolated from ... 5α-reductase inhibitors (or 5-alpha-reductase inhibitors) are a group of drugs with antiandrogenic activity, used in the ... The enzyme 5α-reductase is involved in the conversion of testosterone to the active form dihydrotestosterone by reducing the Δ4 ...
Buy 5 alpha-Reductase 2 Inhibitors from Santa Cruz. View and select products within our 5 alpha-Reductase 2 Inhibitors category ... An inhibitor of 5α-Reductase 1 and 5α-Reductase 2. 188589-66-4. sc-361152. sc-361152A. 10 mg. 50 mg. $195.00. $825.00. 0. ... A dual inhibitor of 5α-reductase isoenzymes type 1 and 2. 164656-23-9. sc-207600. 10 mg. $167.00. 1. ... 5 alpha-Reductase 2 Inhibitors. Steroid 5α-Reductase is an important enzyme in androgen physiology because it catalyzes the ...
Five-alpha Reductase Inhibitors (5ARIs) finasteride and dutasteride are the competitive and specific inhibitors of 5α-reductase ... Five-alpha Reductase Inhibitors have been investigated predominantly for their effects on BPH associated lower urinary tract ... Long-term use of 5a-reductase inhibitors and the risk of male breast cancer. Cancer Causes Control. 2014;25:1577-82. [ Links ] ... Bird ST, Brophy JM, Hartzema AG, Delaney JA, Etminan M. Male breast cancer and 5a-reductase inhibitors finasteride and ...
Type 2 alpha 5 reductase operates below neutral in our scalps. So by raising our bodily pH we can directly reduce the amount of ... Amazingly this is a method thats far more effective at inhibiting alpha 5 reductase from creating DHT in the scalp, than any ... Type 2 alpha 5 reductase is an enzyme that converts testosterone to dihydroxytestosterone. ... 5 alpha reductase is an enzyme in the body that converts testosterone into DHT which then goes on to cause hair loss in men ...
First-line medical therapy includes α 1blockers and 5α-reductase inhibitors (5ARIs), such as finasteride and dutasteride. 5ARI ... First-line medical therapy includes α 1blockers and 5α-reductase inhibitors (5ARIs), such as finasteride and dutasteride. 5ARI ...
5-Alpha-Reductase Inhibitors: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape ...
... information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Adverse events of 5- ... AN EPIDEMIOLOGIC EVALUATION OF ADVERSE EVENTS OF 5-ALPHA-REDUCTASE INHIBITORS Patient advocacy groups are another source for ... This page was created to provide a list of resources where you can find more information about reported adverse events of 5- ... alpha reductase inhibitors, which is sometimes referred to as post-finasteride syndrome. Some patients who have taken ...
Alpha-Estradiol Inhibitor Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication ... Inhibitor CGP-53153 is a steroidal inhibitor of 5 alpha reductase with IC50s of 36 and 262 nM in rat and human prostatic tissue ... Inhibitor 99.79% Dutasteride (GG745) is a potent inhibitor of both 5 alpha-reductase isozymes. Dutasteride may possess off- ... Kinase Inhibitor Library Epigenetics Compound Library Clinical Compound Library Anti-Infection Compound Library Cell Cycle/DNA ...
alpha reductase inhibitor (dutasteride) only for 1 year. Group2 will be those who switch. from alpha blocker to dutasteride and ... of those taking both alpha blocker and dutasteride for 1 year.. composed of. ... Any previous 5 ARI administration. - Type 1 DM or Type 2 DM regardless of treatment. - Clinically significant endocrine ... IPSS score will be evaluated after 1 year of treatment of 5 ARI. At every visit, use of. above prohibited medicines and other ...
New and Potent 5-alpha-reductase Inhibitors are available. Including 5-alpha-reductase inhibitor drugs in clinical trials. ... dual 5alpha-reductase inhibitor Dutasteride is a dual 5-a reductase inhibitor that inhibits conversion of testosterone to ... The Genomic Alterations of 5汐-Reductases and Their Inhibitor Finasteride*s Effect in Bladder Cancer, Anticancer Res, 2017, Dec; ... High Purity Kinase Inhibitors on Signaling Pathways. Trusted by 10,000+ Scientists since 2006 Search. ...
Possible role of 5-alpha reductase inhibitors in non-invasive bladder urothelial neoplasm: multicentre study. Antonio L. ... Possible role of 5-alpha reductase inhibitors in non-invasive bladder urothelial neoplasm: multicentre study. Minerva Urol ... We aimed to evaluate whether 5-alpha reductase inhibitors (5-ARI) have a role in NMIBC.. METHODS: We retrospectively evaluated ... The population was classified into two groups: treated and untreated with 5-ARIs. The enrolled patients were in treatment with ...
How to use Finasteride Tablet 5 Alpha-Reductase Inhibitors. Read the Patient Information Leaflet provided by your pharmacist ... List Finasteride Tablet 5 Alpha-Reductase Inhibitors side effects by likelihood and severity. ... What should I know regarding pregnancy, nursing and administering Finasteride Tablet 5 Alpha-Reductase Inhibitors to children ...
5-Alpha Reductase Inhibitors Drug Class Overview, Drugs, Side Effects, and Interactions. Get your free 5-Alpha Reductase ... Inhibitors Drug Coupon and Discount at Rebates.com ... 5-Alpha Reductase Inhibitors Uses. You will find the uses for 5 ... 5-Alpha reductase inhibitors can also be used to limit the production of androgens in transwomen. This is a part of the hormone ... 5-Alpha reductase inhibitors have also been used to treat prostate cancer, but there have been many issues with this treatments ...
5 alpha reductase inhibitors for prostatitis like Proscar and Avodart have side effects, warnings and precautions for men ... 5a-reductase inhibitors, and alpha-blockers, but their use can be associated with some significant side effects. Natural ... 5 Alpha Reductase Inhibitors for Prostatitis. What Are They?. 5 Alpha reductase inhibitors are prescribed for prostatitis to ... The positive aspect of natural therapies such as these is that they do not cause the negative side affects associated with 5 ...
... including medications such as alpha-blockers, surgeries like TUMT, and lifestyle changes. ... Alpha blockers for BPH. This class of medications works by relaxing the bladder neck muscles and the muscle fibers in the ... You can expect an increase in urine flow and a less frequent need to urinate within a day or two if you take an alpha blocker ... Taking a combination of an alpha blocker and a 5-alpha reductase inhibitor provides greater symptom relief than taking either ...
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... alphareductase inhibitor for the treatment of frontal fibrosing alopecia. ... Researchers looked at the efficacy and safety of 5‐ ... alphareductase inhibitor treatment" * Pingback: Stem cells for ... alphareductase inhibitor has been reported with some treatment success in severe cases of frontal fibrosing alopecia, so ... alphareductase inhibitor could achieve either disease stability or reduction in the rate of progression in selected cases. ...
Anticholinesterase inhibitor explanation free. What is Anticholinesterase inhibitor? Meaning of Anticholinesterase inhibitor ... Looking for online definition of Anticholinesterase inhibitor in the Medical Dictionary? ... Cholinesterase inhibitor.. alpha-2 plasmin inhibitor. Alpha-2 antiplasmin.. alpha-glucosidase inhibitor. An oral drug that ... tumor necrosis factor alpha inhibitor. A drug that blocks the effects of tumor necrosis factor alpha (TNF-alpha), a ...
Medications to treat benign prostatic hyperplasia include 5-alpha-reductase inhibitors and alpha-1-adrenergic blockers (alpha- ... Alpha-1-adrenergic blockers (alpha-blockers). These drugs relax smooth muscle tissue within the prostate by blocking the effect ... inhibitors used to treat ED sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) as the combination also can lead ... Thus, they were more likely to respond to an alpha-blocker.. A review article published in The Journal of Urology found that ...
1 antonym for inhibitor: activator. What are synonyms for 5-alpha reductase inhibitor? ... Synonyms for 5-alpha reductase inhibitor in Free Thesaurus. Antonyms for 5-alpha reductase inhibitor. ... Half of the respondents indicated they would try an alpha-blocker alone, one-third would initiate an alpha-blocker in ... reductase+inhibitor,FreeThesaurus.com,/a,,/div, ,!--End of Graphic Thesaurus by FreeThesaurus.com--,. The code for attribution ...
... is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits ... Kinase Inhibitor Library Immuno-Oncology Compound Library Epigenetics Compound Library Clinical Compound Library Anti-Infection ... 12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%[1]. ... 12-O-Methylcarnosic acid12-Methoxycarnosic acid5 alpha Reductase5α-reductaseInhibitorinhibitorinhibit ...
  • Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme. (wikipedia.org)
  • MK-386 has been found to significantly decrease concentrations of DHT in sebum, similarly to the selective 5α-reductase type II inhibitor finasteride. (wikipedia.org)
  • Structural differences between mammalian and trypanosome 6-phosphogluconate dehydrogenase have allowed for the development of selective inhibitors of the enzyme. (wikipedia.org)
  • Unlike norethisterone which is purely progestogenic, 5α-DHNET has been found to possess both progestogenic and marked antiprogestogenic activity, showing a profile of progestogenic activity like that of a selective progesterone receptor modulator (SPRM). (wikipedia.org)
  • The first drug that was used was non-selective alpha blocker, named phenoxybenzamine and was used to treat BPH. (wikipedia.org)
  • Hypotension and its complications (such as weakness and dizziness) are a constant risk, however, even though a selective alpha-1a blocker is being used. (wikipedia.org)
  • Researchers reviewed articles published on the use of 5alphareductase inhibitor to treat frontal fibrosing alopecia between 2005 and 2017. (healthcert.com)
  • Using a database query software designed at our institution, we collected the first screening PSA test for all men screened from 2014 to July of 2017 taking a 5-ARI in the year prior. (auanet.org)
  • American Academy of Ophthalmology (2014), Alpha-Blocker Patient Advisory: ASCRS and AAO Information Statement (PDF), retrieved 2017-05-12. (wikipedia.org)
  • Five-alpha Reductase Inhibitors have been investigated predominantly for their effects on BPH associated lower urinary tract symptoms (LUTS) and for the treatment of AGA on account of abundant 5ARI activities in the prostate and skin. (scielo.br)
  • Much of the biological role of DHT has been elucidated in studies of individuals with congenital 5α-reductase type II deficiency, an intersex condition caused by a loss-of-function mutation in the gene encoding 5α-reductase type II, the major enzyme responsible for the production of DHT in the body. (wikipedia.org)
  • 3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene. (wikipedia.org)
  • Gene map locus 19q13.12 BCKDHA: Branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease). (wikipedia.org)
  • In humans, the gene for HMG-CoA reductase is located on the long arm of the fifth chromosome (5q13.3-14). (wikipedia.org)
  • Chromosome 5 is the 5th largest human chromosome, yet has one of the lowest gene densities. (wikipedia.org)
  • The following are some of the gene count estimates of human chromosome 5. (wikipedia.org)
  • Familial Adenomatous Polyposis is caused by a deletion of the APC tumor suppressor gene on the long (q) arm of chromosome 5. (wikipedia.org)
  • Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. (wikipedia.org)
  • Consequently, in both the pathogenic fungus Candida albicans and model organism S. cerevisiae mutations in the gene encoding C-5 sterol desaturase (ERG3) allow the cell to avoid synthesizing the toxic sterol products and have been shown to confer azole resistance. (wikipedia.org)
  • In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase). (wikipedia.org)
  • Within this group are the glutathione S-transferases (GSTs) such as hGSTA4-4 and hGST5.8, aldose reductase, and aldehyde dehydrogenase. (wikipedia.org)
  • In lens cells of the human eye, aldose reductase converts galactose to galactitol. (wikipedia.org)
  • Although aldose reductase can also detoxify methylgloxal, the glyoxalase system is more efficient and seems to be the most important of these pathways. (wikipedia.org)
  • ARIMIDEX is an aromatase inhibitor and used to. (catalogtovarov.gq)
  • Minamestane (INN (former developmental code name FCE-24,928) is a steroidal aromatase inhibitor which was under development by Farmitalia-Carlo Erba as an antineoplastic agent in the mid-1990s but was never marketed. (wikipedia.org)
  • A study conducted nearly 10 years ago, funded by private research and reported by New Scientist, 2 found that Viagra's active compound, sildenafil, works by inhibiting an enzyme called phosphodiesterase-5 (PDE5), which helps control blood flow to the penis. (mercola.com)
  • In patients with ED refractory to oral PDE5 inhibitors, one of these agents can be combined with an injection of PGE1. (medscape.com)
  • The following study is underway to learn more about the relationship between 5-alpha-reductase inhibitors and erectile dysfunction, other sexual dysfunction (ejaculatory and psychosexual dysfunction, low libido, Peyronie's disease), breast outcomes, and depression. (nih.gov)
  • Erectile dysfunction, or ED (the inability to achieve a full erection), occurs in 5 to 8 percent of men, decreased libido (sex drive) in 3 to 6 percent, reduced ejaculate in 1 percent, and breast enlargement or tenderness in 0.5 percent. (healthcommunities.com)
  • Zotarolimus-eluting peripheral stents for the treatment of erectile dysfunction in subjects with suboptimal response to phosphodiesterase-5 inhibitors. (medscape.com)
  • Alhathal N, Elshal AM, Carrier S. Synergetic effect of testosterone and phophodiesterase-5 inhibitors in hypogonadal men with erectile dysfunction: A systematic review. (medscape.com)