A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.
An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.
Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are then rapidly converted by a peroxidase to hydroxyeicosatetraenoic acids. The positional specificity of the enzyme reaction varies from tissue to tissue. The final lipoxygenase pathway leads to the leukotrienes. EC 1.13.11.- .
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Refers to animals in the period of time just after birth.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Adherence of cells to surfaces or to other cells.
Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).
The various physical methods which include wind, insects, animals, tension, and water, by which a plant scatters its seeds away from the parent plant.
A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
The measure of the level of heat of a human or animal.
20-carbon saturated monocarboxylic acids.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
A plant genus of the family ZYGOPHYLLACEAE. It is sometimes called chaparral but that is a generic word which is used with a number of other plants. Members contain NORDIHYDROGUAIARETIC ACID.
The buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A plant genus of the family ASTERACEAE with strong-smelling foliage. It is a source of SANTONIN and other cytotoxic TERPENES.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.
The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.
... sorbic acid MeSH D10.251.355.920 - trans fatty acids MeSH D10.251.400.092 - acetic acids MeSH D10.251.400.092.129 - acetic acid ... fatty acids, omega-6 MeSH D10.251.355.343.249 - gamma-linolenic acid MeSH D10.251.355.343.500 - linoleic acids MeSH D10.251. ... linolenic acids MeSH D10.251.355.310.640.400 - alpha-linolenic acid MeSH D10.251.355.310.640.425 - gamma-linolenic acid MeSH ... oleic acids MeSH D10.251.355.325.600.525 - oleic acid MeSH D10.251.355.325.600.780 - ricinoleic acids MeSH D10.251.355.325.919 ...
Calbiochem CAS 1191-85-1 Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl ... Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases.. More,, ... Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. ... Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A2 ( ...
... neurons requires loss of PIP2 and generation of a free fatty acid, probably arachidonic acid (AA) by phospholipase A2 (PLA2). ... Fatty acid release and L-current inhibition by Oxo-M are lost in SCG neurons lacking cPLA2. If M1R modulation of L-current ... A, Examples of fatty acid fluorescence in sPLA2−/− and in s/cPLA2−/− mouse SCG neurons. Con, 0 min of stimulation; Oxo-M, 6 min ... 2000) Arachidonic acid modulation of α1H, a cloned human T-type calcium channel. Am J Physiol Heart Circ Physiol 278:H184-H193. ...
... except that the formic acid pretreatment was omitted. BrdUrd stained sections then were immunostained for various neural cell ... 5), including the Islands of Calleja (16) in the ventral forebrain and the subependyma of the olfactory bulb (17, 18). A large ... Figure 5 Localization of BrdUrd-labeled MSCs in neural rich regions of forebrain. (A) Low magnification of forebrain showing ... Azizi et al. (8) infused rat brains with human marrow stromal cells (MSCs) that are capable of expansion, self-renewal, and ...
9163568 - The effect of 5,8,11,14-eicosatetraynoic acid on endothelial cell gene expression.. 9780218 - Endothelial selectins ...
Takami M, Preston SL, Behrman HR. Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via ... Brock TG. Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. ... Cardoso CM, De Meis L. Modulation by fatty acids of Ca2+ fluxes in sarcoplasmic-reticulum vesicles. Biochem J 296: 49-52, 1993. ... Huang JK, Chen WC, Huang CJ, Hsu SS, Chen JS, Cheng HH, Chang HT, Jiann BP, Jan CR. Nordihydroguaiaretic acid-induced Ca2+ ...
Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, ... Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, ... We analyzed the effect of four long-chain free fatty acids (AA, 20:4; DHA, 22:6; palmitic acid, 16:0; and nonadecanoic acid, 19 ... Fatty acids act as substrates for acyl-coenzyme A (acyl-CoA) molecules by several synthases. These activated fatty acids can be ...
PEA was identified in 1957 as a fatty acid amide with anti-inflammatory properties (Kuehl et al., 1957). While PEA is a known ... Taylor, B. K. (2013). N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia. Pain 154, 326-327 ... Chemokine ligands are grouped into four families based on their amino acid sequence: alpha (CXC), beta (CC), gamma (C), and ... Specifically, 15d-PGJ2 and troglitazone inhibited TNFα expression in monocytes stimulated by okadaic acid or phorbol ester but ...
Galbraith, H., and Miller, T. B., 1973b, Effect of long chain fatty acids on bacterial respiration and amino acid uptake, J. ... XI. Relationship between stimulated oxidative metabolism and hydrogen peroxide formation, and intracellular killing, J. ... Dubos, R. J., 1950, The effect of organic acids on mammalian tubercle bacilli, J. Exp. Med. 42:319.CrossRefGoogle Scholar ... Canfield, R. E., 1963, The amino acid sequence of egg white lysozyme, J. Biol. Chem. 238:2698.PubMedGoogle Scholar ...
Marc Riehle 1 , Dmitry Tsvetkov 1 2 3 , Björn-Oliver Gohlke 4 , Robert Preissner 4 , Christian Harteneck 1 , Maik Gollasch 5 6 ... Amino acid (aa) sequence alignment of the three Drosophila TRPC channels revealed 50 aa residues highly conserved in PUFA- ... Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids Naunyn Schmiedebergs Arch Pharmacol. 2018 ... subfamily and their activation by polyunsaturated fatty acids (PUFAs). Here, we analyzed the structure-function relationship of ...
PAR2 stimulation induces release of arachidonic acid and PGE2 from epithelial cells (Kong et al., 1997), and these mechanisms ... whereas bradykinin transactivates TRPV1 through the generation of 12-lipoxygenase metabolites of arachidonic acid (Shin et al ... 8a). In TRPV1+/+ mice, intraplantar injection PAR2-AP but not PAR2-RP (1 μg/paw) also caused a sustained decrease in latency of ... 8b). In contrast, PAR2-AP did not affect the latency of withdrawal in TRPV1-/- mice. Thus, TRPV1 is required for PAR2-induced ...
... known as nordihydroguaiaretic acid (NDGA) is a potent antioxidant and was thought by some scientists to be a potential cancer ... 7. Salari H, Braquet P, Borgeat P. Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid ... Clinical experience with nordihydroguaiaretic acid-"chapparel tea" [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39 ... Clinical experience with nordihydroguaiaretic acid-"chapparel tea" [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39 ...
However, nordihydroguaiaretic acid, a lipoxygenase inhibitor, decreased levels of NF-kappa B to background levels. This would ... an inhibitor of arachidonic acid metabolism, prior to exposure to crocidolite, abrogated crocidolite-induced NF-kappa B DNA- ... suggest that lipoxygenase metabolites of arachidonic acid, produced following lipid peroxidation, are involved in the cellular ... 1997 Sep;105 Suppl 5(Suppl 5):1127-30. doi: 10.1289/ehp.97105s51127. ...
Infusing arachidonic acid increased thromboxane synthesis to the same extent in phosgene-exposed lungs as in control lungs; ... a nonmetabolized competitive inhibitor of arachidonic acid metabolism, or the leukotriene receptor blockers, FPL 55712 and LY ...
The Bcl3-RXRα interaction is influenced by the presence of 9-cis-retinoic acid (38), whereas ligand does not appear to be ... Briefly, human ERRα cDNA corresponding to the ligand-binding domain (amino acids 197 to 422) was cloned into pAS2-1 vector and ... Taken together, these results identify at least two Bcl3 interacting regions within amino acids 359 to 403 and 144 to 359 of ... The numbers correspond to amino acid positions. Bacterially expressed GST, GST-ERRα, or GST-Bcl3 fusion proteins were used with ...
... sorbic acid MeSH D10.251.355.920 - trans fatty acids MeSH D10.251.400.092 - acetic acids MeSH D10.251.400.092.129 - acetic acid ... fatty acids, omega-6 MeSH D10.251.355.343.249 - gamma-linolenic acid MeSH D10.251.355.343.500 - linoleic acids MeSH D10.251. ... linolenic acids MeSH D10.251.355.310.640.400 - alpha-linolenic acid MeSH D10.251.355.310.640.425 - gamma-linolenic acid MeSH ... oleic acids MeSH D10.251.355.325.600.525 - oleic acid MeSH D10.251.355.325.600.780 - ricinoleic acids MeSH D10.251.355.325.919 ...
H]phosphatidic acid and [. $^3$. H]diacylglycerol, and [. $^3$. H]phosphatidic acid formation preceded the formation of [. $^3$ ... It was previously reported that yeast elicitor transiently increased oleanolic acid and ursolic acid in Scutellaria baicalensis ... melittin-induced arachidonic acid release was not affected by EMF in both cells. In cell-free $PLA_2$. assay, we failed to ... The hydrolyzed myristic acid was quantified using a dark mutant of Vibrio harveyi (designated as M-17). The in vivo light ...
Fingerprint Dive into the research topics of Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. Together they form a unique fingerprint. ...
... lactic acid, malic acid, citric acid, glycolic acid, mandelic acid, tartaric acid, glyceric acid or ascorbic acid or the salts ... eicosatetraynoic or 5,8,11 -eicosatrynoic acid or an ester or an amide thereof, and combinations thereof. ... azelaic acid, caffeic acid or kojic acid; emollients; hydrating or moisturizing agents such as glycerol, PEG 400, ... By the term "amino acid residue" is particularly intended a residue derived from lysine, from glycine or from aspartic acid, ...
Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ... Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ... Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ... Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ...
Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR. Hypertension. 2001;37(3):887-893. ... Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR. / Pomposiello, Silvia I.; Carroll ... title = "Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR", ... Fingerprint Dive into the research topics of Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is ...
In vitro effects of arachidonic acid and of inhibitors of its metabolism on the dog thyroid gland.. ... Effects of arachidonic acid on the thyroid gland in vitro. par Boeynaems, Jean-Marie , Van Sande, Jacqueline , Gervy Decoster, ... In vitro effects of arachidonic acid and of inhibitors of its metabolism on the dog thyroid gland. ...
13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three ... 15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5, ... Fatty Acids, Nonesterified (0) * Fatty Acids, Unsaturated (0) * Arachidonic Acids (0) * Eicosanoids (1) * Arachidonic Acids (0) ...
Arachidonic Acid Medicine & Life Sciences * 5,8,11,14-Eicosatetraynoic Acid Medicine & Life Sciences ... Koenigsberg, C. & Ondrey, F. G., Oct 2020, In: Anticancer Research. 40, 10, p. 5417-5421 5 p.. Research output: Contribution to ... 11, 5, p. 938-940 3 p.. Research output: Contribution to journal › Article › peer-review ...
Fatty Acids) [FA] are a diverse group of molecules synthesized by chain elongation of an acetyl-CoA primer with malonyl-CoA (or ... "Fatty Acids (Fatty acyls)" [FA] Fatty Acid. In our body, Fatty Acids are aliphatic acids fundamental to energy production, ... Hydroperoxy Fatty Acids [FA0104] *Hydroxy Fatty Acids [FA0105] *Oxo Fatty Acids [FA0106] *Epoxy Fatty Acids [FA0107] *Methoxy ... Halogenated Fatty Acids [FA0109] *Amino Fatty Acids [FA0110] *Cyano Fatty Acids [FA0111] *Nitro-Fatty Acids [FA0112] *Thia ...
Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid. Arterioscler Thromb Vasc ... Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 ... Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway. Int J Mol ... "Eicosapentaenoic Acid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
Inhibition by eicosatetraynoic acid (ETYA) was more persistent. These results are consistent with previous reports that SHAM ... Salicylhydroxamic acid (SHAM) and 3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride (BW755C) delayed the response ... The hypothesis that arachidonic acid (AA) induction of sesquiterpene accumulation and browning in potato (Solanum tuberosum) is ... Inhibition by Salicylhydroxamic Acid, BW755C, Eicosatetraynoic Acid, and Disulfiram of Hypersensitive Resistance Elicited by ...
Arachidonic Acid , Arachidonic Acids , Brain , Corpus Striatum , Eicosapentaenoic Acid , Fatty Acids , Fatty Acids, Omega-3 , ... Adenosine Triphosphate , Amino Acids , Antipain , Arachidonic Acid , Arachidonic Acids , Catalase , Cell Death , Cell Survival ... Docosahexaenoic Acids , Metabolism , Eicosapentaenoic Acid , Metabolism , Ethnic Groups , Fatty Acids , Metabolism , Female , ... Conjugated linoleic acid (CLA) is the mixture of positional and geometric isomers of linoleic acid (LA), which is found ...
Apoptosis , Cell Death , Cell Survival , DNA Fragmentation , Egtazic Acid , Flufenamic Acid , Genes, myc , Genes, p53 , ... Treatment with either ursodeoxycholic acid (UDCA) or lithocholic acid (LCA) resulted in a dose- and time-dependent decrease in ... Arachidonic Acid , Arachidonic Acids , Cytosol , Ethylmaleimide , Hep G2 Cells , Hepatoblastoma , Humans , Indomethacin , ... Apoptosis , Bile Acids and Salts , Bile , Calcimycin , Calcium , Carcinoma, Hepatocellular , Cell Death , Cell Survival , ...
Gramlich L, Meddings L, Alberda C, Wichansawakun S, Robbins S, Driscoll D, Bistrian B. Essential Fatty Acid Deficiency in 2015 ... A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14- ... "8,11,14-Eicosatrienoic Acid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "8,11,14-Eicosatrienoic Acid" by people in this website by year ...
Arachidonic acid (AA), a biologically active fatty acid, plays a crucial role as a mediator of signaling pathways involved in ... γ-Linolenic acid, a precursor of AA, also inhibited cell growth, whereas other unsaturated and saturated fatty acids had no ... Arachidonic acid (AA), a biologically active fatty acid, plays a crucial role as a mediator of signaling pathways involved in ... γ-Linolenic acid, a precursor of AA, also inhibited cell growth, whereas other unsaturated and saturated fatty acids had no ...
  • Inhibition by eicosatetraynoic acid (ETYA) was more persistent. (semanticscholar.org)
  • Micromolar concentrations of 2 classical inhibitors of lipoxygenase, 5,8,11-eicosatriynoic acid (ETI) and 5,8,11,14-eicosatetraynoic acid (ETYA), were found to cause a significant inhibition of the mixture of isozymes of affinity purified rat and human liver glutathione S-transferase (GST) with activity towards 1-chloro-2,4-dinitrobenzene (CDNB). (propecia2020.site)
  • Vinyl perdeuterated arachidonic acid (20:4 5,8,11,14 -d 8 ) was prepared from eicosatetraynoic acid (ETYA) and was esterified with 1-palmi-toyl-sn-glycero-3-phosphocholine to yield 1 -palmitoyl-2-vinylperdeuterioarachidonoyl-sn-glycero-3-phos-phocholine [(16:0)(20:4-d 8 )PC]. (elsevier.com)
  • Nordihydroguaiaretic acid (NDGA), eicosatetraynoic acid (ETYA), and indomethacin, extensively utilized inhibitors of the cyclooxygenase and lipoxygenase branches of the arachidonate cascade, also inhibit cytochrome P-450-dependent arachidonic acid metabolism. (vanderbilt.edu)
  • However, we found previously that M 1 R inhibition of N-current in superior cervical ganglion (SCG) neurons requires loss of PIP 2 and generation of a free fatty acid, probably arachidonic acid (AA) by phospholipase A 2 (PLA 2 ). (jneurosci.org)
  • Our alternative model for N-current modulation proposes that inhibition requires generation of free fatty acid by phospholipase A 2 (PLA 2 ). (jneurosci.org)
  • Fatty Acids (Fatty acyls) and the conjugates and derivatives of these Fatty Acids, are a class of lipids synthesized by chain-elongation of an acetyl-CoA primer with malonyl-CoA or methylmalonyl-CoA groups through the fatty acid synthesis process. (wellnessadvantage.com)
  • In lipid science , a Fatty Acid is an organic carboxylic acid , with a long unbranched aliphatic tail (chain), which my either be saturated or unsaturated. (wellnessadvantage.com)
  • In our diet and in our body, Eicosanoids are a class of fatty acid compounds named after and generally derived from C20 fatty acids, that have hormone-like effects ( autacoid effects , mediated by specialized eicosanoid receptors ). (wellnessadvantage.com)
  • In lipid science, four families of the unsaturated fatty acid Eicosanoids are the prostaglandins, prostacyclins, the thromboxanes and the leukotrienes. (wellnessadvantage.com)
  • Important polyunsaturated fatty acid found in fish oils. (harvard.edu)
  • Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid. (harvard.edu)
  • Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration. (harvard.edu)
  • Gramlich L, Meddings L, Alberda C, Wichansawakun S, Robbins S, Driscoll D, Bistrian B. Essential Fatty Acid Deficiency in 2015: The Impact of Novel Intravenous Lipid Emulsions. (umassmed.edu)
  • Arachidonic acid (AA), a biologically active fatty acid, plays a crucial role as a mediator of signaling pathways involved in cell proliferation and survival. (elsevier.com)
  • Although the receptor antagonists have high potential in treating asthma and other diseases where drug effects are clearly mediated by the leukotriene receptors, enzyme activity inhibitors may be better candidates for chemopreventive intervention, because inhibition of these enzymes directly reduces fatty acid metabolite production, with concomitant damping of the associated inflammatory, proliferative, and metastatic activities that contribute to carcinogenesis. (aacrjournals.org)
  • The present invention relates to novel uridine esters of the general formula ##STR00001## wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R' represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. (patents.com)
  • The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination. (patents.com)
  • In organic chemistry, Oxoeicosapolyenoic acids are a subclass of organic compounds in the eicosanoids subclass of the fatty acyl class [FA class] within the lipids superclass , consisting of an eicosapolyenoic acid (C20 fatty acid) with more than one C=C double bonds on the chain. (wellnessadvocate.com)
  • To describe precisely the structure of a fatty acid molecule, one must give the length of the carbon chain (number of carbon atoms), the number of double bonds and also the exact position of these double bonds. (patentgenius.com)
  • Thus the use of short-term feeding with a saturated fatty acid diet in the prevention of acute irradiation damage to the intestine warrants further investigation in humans. (edwardedmonds.com)
  • Preincubation of RFL-6 cells with 5,8,11,14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism, prior to exposure to crocidolite, abrogated crocidolite-induced NF-kappa B DNA-binding activity to background levels. (nih.gov)
  • Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. (vanderbilt.edu)
  • Human being VKOR can transfer electrons from proteins disulfide isomerase also a thioredoxin relative and the principal catalyst for disulfide relationship development in eukaryotic secreted protein to supplement K a quinone in the endoplasmic reticulum membrane (4-8). (antibodyassay.com)
  • To the end we used a proteins MK-0752 fusion which makes the enzyme β-galactosidase delicate to disulfide relationship development (14). (antibodyassay.com)
  • Inhibits cyclooxygenase (ID 50 = 8 µM), 5-lipoxygenase (ID 50 = 10 µM), 12-lipoxygenase (ID 50 = 300 nM), and 15-lipoxygenase (ID 50 = 200 nM) in whole cells. (emdmillipore.com)
  • However, nordihydroguaiaretic acid, a lipoxygenase inhibitor, decreased levels of NF-kappa B to background levels. (nih.gov)
  • This would suggest that lipoxygenase metabolites of arachidonic acid, produced following lipid peroxidation, are involved in the cellular signalling events to NF-kappa B transcription factor induction by asbestos. (nih.gov)
  • The hypothesis that arachidonic acid (AA) induction of sesquiterpene accumulation and browning in potato (Solanum tuberosum) is mediated by a lipoxygenase metabolite of AA was tested using lipoxygenase inhibitors. (semanticscholar.org)
  • Creating conditions similar to those that occur during exposure of cells to microgravity induced a sixfold increase of apoptotic bodies and DNA fragments in human lymphocytes, paralleled by an early (within 2 h) fourfold increase in 5-lipoxygenase (5-LOX) activity and a fivefold decrease in mitochondrial membrane potential and increase in cytochrome c release (within 4 and 8 h, respectively). (uniss.it)
  • Moreover, 5-lipoxygenase inhibitors 5,8,11,14-eicosatetraynoic acid and MK886, cyclooxygenase inhibitor indomethacin, caspase-3 and caspase-9 inhibitors Z-DEVD-FMK and Z-LEHD-FMK, but not nitric oxide synthase inhibitor Nomega-nitro-l-arginine methyl ester, significantly reduced the cell death-inducing effect of AEA. (greenmedinfo.health)
  • The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang Ⅱ were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH). (bvsalud.org)
  • The intracellular calcium chelator EGTA-acetoxymethylester reduced 5-LOX activity and apoptosis to 30-40% of controls, whereas the p38 mitogen-activated protein kinase inhibitor SB203580 was ineffective. (uniss.it)
  • Eicosapentaenoic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. (harvard.edu)
  • This graph shows the total number of publications written about "Eicosapentaenoic Acid" by people in Harvard Catalyst Profiles by year, and whether "Eicosapentaenoic Acid" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Eicosapentaenoic Acid" by people in Profiles. (harvard.edu)
  • Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway. (harvard.edu)
  • Inhibition by Salicylhydroxamic Acid, BW755C, Eicosatetraynoic Acid, and Disulfiram of Hypersensitive Resistance Elicited by Arachidonic Acid or Poly-l-Lysine in Potato Tuber. (semanticscholar.org)
  • In our body, the biosynthesis of Octadecanoids [FA02] are involved with the metabolism of Linoleic Acid (LA) . (wellnessadvantage.com)
  • Dairy products derived from the milk of cows fed in pastures are characterised by higher amounts of conjugated linoleic acid and α-linolenic acid (ALA), and several studies have shown their ability to reduce cardiovascular risk. (edwardedmonds.com)
  • In nature, most Fatty Acids have a chain of an even number of carbon atoms, from 4 to 28. (wellnessadvantage.com)
  • In lipid science , the Fatty acyl [FA] group , includes the Fatty Acids and Conjugates [FA01] class, and is characterized by a repeating series of methylene groups that impart a hydrophobic character to these lipids. (wellnessadvantage.com)
  • In our body, Docosanoids [FA04] are a subclass of the Fatty acyl [FA] class of lipids used as signaling molecules made by oxygenation of twenty-two-carbon essential fatty acids, (EFAs), especially Docosahexaenoic acid (DHA) . (wellnessadvantage.com)
  • In organic chemistry, Hydroperoxyeicosatrienoic acids are a subclass organic compounds in the fatty acyls class of the lipids and lipid-like molecules superclass , containing an eicosanoic acid with an attached hydroperoxyl group and three CC double bonds. (wellnessadvocate.com)
  • At first it must be recalled that if the majority of the fatty acids found in lipids are monocarboxylic acids, some of the fatty acids are dicarboxylic and constitute important metabolic productsof the previous ones. (patentgenius.com)
  • In our body, Eicosanoids are a family of signaling molecules (hormone-like substances) derived from the oxidation of twenty-carbon Essential Fatty Acids, (EFAs). (wellnessadvantage.com)
  • Eicosanoids derived from the arachidonic acid cascade have been implicated in the pathogenesis of a variety of human diseases, including cancer, and are now believed to play important roles in tumor promotion, progression, and metastatic disease. (aacrjournals.org)
  • Besides 12( S )-HETE, other LO metabolites, particularly the 5-LO products (5-HETEs), have been implicated in cancer development. (aacrjournals.org)
  • The remainder was presumably derived to a varying degree from endogenous non-glucose sources such as fructose and/or amino acids. (microbiologyresearch.org)
  • We tested the hypothesis that cyclooxygenase-independent vasodilation produced by arachidonic acid (AA) is mediated by epoxyeicosatrienoic acids (EETs) and is blunted in the spontaneously hypertensive rat (SHR). (elsevier.com)
  • [email protected]#To investigate the relationship between cerebroprotection of pinocembrin and epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH). (bvsalud.org)
  • Finally, creating conditions similar to those that occur during exposure of cells to microgravity did not induce apoptosis in human lymphoma U937 cells, which did not express an active 5-LOX. (uniss.it)
  • A new generation of heteroatom analogs of arachidonic acid are documented as powerful and selective inhibitors of the cytochrome P-450-dependent arachidonic acid oxygenase reaction (IC50, 5-10 microM) with little effect on either cyclooxygenase or soybean lipoxidase at 100 microM. (vanderbilt.edu)
  • 1997 Sep;105 Suppl 5(Suppl 5):1127-30. (nih.gov)
  • Rev. in Oncology/Hematology, 1993, 14:29-39). (patents.com)
  • Oct. 1996) vol. 10, No. 5, pp. 280-287) (Abstract Sent). (patents.com)
  • Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G-protein-coupled receptors. (umn.edu)
  • Similar membrane potential and cytochrome c release were observed in isolated mitochondria treated with physiological amounts of 5-LOX and were enhanced by creating conditions similar to those that occur during exposure of cells to microgravity. (uniss.it)
  • Our findings support a model of M 1 R-meditated channel modulation that broadens rather than restricts the roles of phospholipids and fatty acids in regulating ion channel activity. (jneurosci.org)
  • In our body, Fatty Acids are usually derived from triglycerides or phospholipids. (wellnessadvantage.com)
  • Rajamoorthi, K & Brown, MF 1991, ' Bilayers of Arachidonic Acid Containing Phospholipids Studied by 2 H and 31 P NMR Spectroscopy ', Biochemistry , vol. 30, no. 17, pp. 4204-4212. (elsevier.com)
  • Other diseases involving pathological affectation of fatty acids, albeit rare, include X-linked adrenoleukodystrophy, a progressive neurodegenerative disorder caused by the loss-of-function mutation in the ATP-binding cassette transporter subfamily D member 1 gene. (frontiersin.org)
  • Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. (emdmillipore.com)
  • showed that the PUFA linolenic acid (n-3 PUFA) prevents neuronal death in an animal model of transient global ischemia even when administered as long as 30 min after the insult. (frontiersin.org)
  • Linolenic acid also protected animals treated with kainate against seizures and hippocampal lesions. (frontiersin.org)
  • γ-Linolenic acid, a precursor of AA, also inhibited cell growth, whereas other unsaturated and saturated fatty acids had no effect. (elsevier.com)
  • Many cell types can use either glucose or fatty acids for this purpose. (wellnessadvantage.com)
  • N-Acetylneuraminic acid, N-acetylated hexosamines, glucose, galactose, and xylitol were likewise well separated from each other under isocratic elution conditions. (statescale.tk)
  • SUMMARY: Earlier studies on the fermentation of D-[1- 14 C]- and D-[3,4- 14 C]glucose by Lactobacillus divergens showed that lactate was the major fermentation product and that it was probably produced by glycolysis. (microbiologyresearch.org)
  • Results obtained with D-[U- 14 C]glucose showed that approximately three-quarters of the lactate but less than 10% each of the formate and acetate were produced from glucose. (microbiologyresearch.org)
  • In one model, M 1 -muscarinic receptors (M 1 Rs) may inhibit both Ca 2+ (L- and N-) and K + (M-) currents by losing a putative interaction between channels and phosphatidylinositol-4,5-bisphosphate (PIP 2 ). (jneurosci.org)
  • Importantly, co-administration of 0.2 mg·kg(-1) 14, 15-EEZE, a putative selective EET antagonist, weakened the beneficial effects of pinocembrin. (bvsalud.org)
  • Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. (frontiersin.org)
  • Nicotinic acid: current status in lipid management and cardiovascular disease prevention. (masslock.top)
  • We used two tests of analgesia (the acetic acid writhing test and the hot-water tail-flick test) and selective kappa agonists and antagonists given at supraspinal and spinal sites in mice. (propecia2020.site)
  • The nuclear receptor superfamily of transcription factors regulate the expression of genes involved in multiple cellular processes including metabolism, growth, differentiation, and inflammation ( 6 , 14 , 42 ). (asm.org)
  • In vitro effects of arachidonic acid and of inhibitors of its metabolism on the dog thyroid gland. (ac.be)
  • Stem cells also have been identified in the gut, gonads, skin, and brain of adults ( 5 , 6 ). (pnas.org)
  • 8 ) infused rat brains with human marrow stromal cells (MSCs) that are capable of expansion, self-renewal, and differentiation into multiple mesenchymal cell lineages ( 9 , 10 ). (pnas.org)
  • showed that neural stem cells differentiated into myeloid and lymphoid cell lineages after transplantation into the hematopoietic system of irradiated hosts ( 11 ). (pnas.org)
  • Cells were harvested by incubating with 0.25% trypsin for 5 min at room temperature followed by gentle scraping. (pnas.org)
  • In our body, Docosahexaenoic acid is a precursor to bioactive mediators that possess both anti-inflammatory and protective properties. (wellnessadvantage.com)