5,8,11,14-Eicosatetraynoic Acid
Masoprocol
Lipoxygenase
Lipoxygenase Inhibitors
Arachidonic Acid
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Indomethacin
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
SRS-A
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
Fatty Acids, Unsaturated
Arachidonate Lipoxygenases
Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are then rapidly converted by a peroxidase to hydroxyeicosatetraenoic acids. The positional specificity of the enzyme reaction varies from tissue to tissue. The final lipoxygenase pathway leads to the leukotrienes. EC 1.13.11.- .
Quinacrine
Prostaglandins
Prostaglandins E
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
Phospholipases A
List of MeSH codes (D10)
... sorbic acid MeSH D10.251.355.920 - trans fatty acids MeSH D10.251.400.092 - acetic acids MeSH D10.251.400.092.129 - acetic acid ... fatty acids, omega-6 MeSH D10.251.355.343.249 - gamma-linolenic acid MeSH D10.251.355.343.500 - linoleic acids MeSH D10.251. ... linolenic acids MeSH D10.251.355.310.640.400 - alpha-linolenic acid MeSH D10.251.355.310.640.425 - gamma-linolenic acid MeSH ... oleic acids MeSH D10.251.355.325.600.525 - oleic acid MeSH D10.251.355.325.600.780 - ricinoleic acids MeSH D10.251.355.325.919 ...
Evidence against a role for lipoxygenase-derived products of arachidonic acid in the lamb ductus arteriosus
4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate), and inhibitors of arachidonate lipoxygenase and cyclo-oxygenase (compound BW755C ... Evidence against a role for lipoxygenase-derived products of arachidonic acid in the lamb ductus arteriosus Can J Physiol ... BW755C (10(-6) to 10(-5) M) and FPL55712 (10(-5) M) contracted the hypoxic ductus; however, their action was abolished by ... 5) M. The contraction of hypoxic tissues to either BW755C or FPL55712 increased further upon raising the oxygen tension of the ...
NIOSHTIC-2 Search Results - Full View
Cyclooxygenase inhibitors; TerraQSAR-LOGP computed octanol/water partition coefficients (CLOGPs)
niflumic acid 4394-00-7 C13H9F3N2O2 282.22 5.23 ebselen 60940-34-3 C13H9NOSe 274.18 1.63 nimesulide 51803-78-2 C13H12N2O5S ... tolfenamic acid 13710-19-5 C14H12ClNO2 261.71 4.36 resveratroll 501-36-0 C14H12O3 228.25 2.33 piceatannol 4339-71-3 C14H12O4 ... 6-methoxy-2-naphthylacetic acid 23981-47-7 C12H10O3 202.21 3.19 valeryl salicylate 64206-54-8 C12H14O4 222.24 1.19 ... 169590-42-5 C17H14F3N3O2S 381.38 1.19 deracoxib 169590-41-4 C17H14F3N3O3S 397.37 1.32 oxindanac 68548-99-2 C17H14O4 282.29 3.14 ...
DeCS
A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to ... A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to ... 5,8,11,14-Eicosatetraynoic Acid - Preferred Concept UI. M0023258. Scope note. ...
Pesquisa | Portal Regional da BVS
While some studies have shown that marine-derived omega-3 fatty acids (eicosapentaenoic acid [EPA] and/or docosahexaenoic acid ... Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory ... The bioactive components of fish oil (n-3 eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have strong inflammation- ... Some studies have shown that supplementing diets with n-3 polyunsaturated fatty acids (eicosapentaenoic acid [EPA] and ...
DeCS 2011 - December 22, 2011 version
99mTc-Dimercaptosuccinic Acid use Technetium Tc 99m Dimercaptosuccinic Acid 99mTc-DMSA use Technetium Tc 99m Dimercaptosuccinic ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 12-S-Hydroxyeicosatetraenoic Acid use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid ... 99mTc-Diethyl IDA use Technetium Tc 99m Diethyl-iminodiacetic Acid ...
Phosgene Toxicity: Practice Essentials, Background, Pathophysiology
Posttreatment with eicosatetraynoic acid decreases lung edema in guinea pigs exposed to phosgene: the role of leukotrienes. Exp ... These processes may lead to increased arachidonic acid release and thus provide more substrate for lipoxygenase (ie, more ... Phosgene interacts with biological molecules through two primary reactions: hydrolysis to hydrochloric acid and acylation ... 5] Other pulmonary irritant gases, such as chlorine, are so noxious that exposed persons flee the immediate area of release, ...
Medscape | J Neuroinflammation - Publication Information
The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an ... Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons. May 29, 2012 ... NADPH oxidase-mediated redox signal contributes to lipoteichoic acid-induced MMP-9 upregulation in brain astrocytes. July 06, ... The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of ...
Interactions between tumor necrosis factor-alpha, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin...
... eicosatetraynoic acid (10 microM), or nordihydroguaiaretic acid (30 microM) resulted in inhibition of TNF alpha-stimulated CRH ... 2021 May;58(5):2133-2144. doi: 10.1007/s12035-020-02241-5. Epub 2021 Jan 7. Mol Neurobiol. 2021. PMID: 33415683 ... doi: 10.1007/978-1-4899-2064-5_13. Adv Exp Med Biol. 1988. PMID: 2906518 Review. ...
A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental...
1992), clofibric acid [2-(p-chlorophenoxy)-2-methylpropionic acid] (Barrass et al. 1993; Marsman et al. 1992), nafenopin (2- ... perfluorinated acids, chlorinated solvents, and chloroacetic acids, either alone or in combinations relevant to human exposures ... Steenland K, Fletcher T and Savitz D (2010) Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA), ... Drugs that have PPAR-α agonist activity include fibrates or fibric acid derivatives (which are primarily PPAR-α agonists), ...
MeSH Browser
Fatty Acids [D10.251] * Fatty Acids, Unsaturated [D10.251.355] * Eicosanoids [D10.251.355.255] * Arachidonic Acids [D10.251. ... Fatty Acids, Unsaturated (1973-1974). Public MeSH Note. 91; was see under FATTY ACIDS, UNSATURATED 1975-90. History Note. 91(75 ... A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to ... A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to ...
MeSH Browser
Fatty Acids [D10.251] * Fatty Acids, Unsaturated [D10.251.355] * Eicosanoids [D10.251.355.255] * Arachidonic Acids [D10.251. ... Fatty Acids, Unsaturated (1973-1974). Public MeSH Note. 91; was see under FATTY ACIDS, UNSATURATED 1975-90. History Note. 91(75 ... A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to ... A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to ...
NDF-RT Code NDF-RT Name
Neutral N0000006806 Amino Acids N0000011372 Amino Acids, Acidic N0000011248 Amino Acids, Aromatic N0000011332 Amino Acids, ... Type VI N0000168671 Collagen Type VII N0000168680 Collagen Type VIII N0000168676 Collagen Type X N0000168666 Collagen Type XI ... Acyclic N0000008269 Acids, Aldehydic N0000007628 Acids, Carbocyclic N0000007629 Acids, Heterocyclic N0000007630 Acids, ... Amino Acid Isomerases N0000167825 Amino Acid Oxidoreductases N0000169801 Amino Acid Transport System A N0000169803 Amino Acid ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
The 16α-hydroxylated Bile Acid, Pythocholic Acid Decreases Food Intake and Increases Oleoylethanolamide in Male Mice. ... We successfully isolated pythocholic acid from ball pythons for experimental use. Pythocholic acid treatment significantly ... Pythocholic acid or deoxycholic acid (DCA) was given by oral gavage in mice. DCA is known to increase N-acyl ... and promoted the conversions of unsaturated fatty acids to saturated fatty acids in Chinese olives. Moreover, 2 °C-stored ...
MESH TREE NUMBER CHANGES - 2003 MeSH
D2.241.81.407 Fatty Acids, Monounsaturated D2.241.81.436.275 Fatty Acids, Omega-3 D2.241.81.436.292 Fatty Acids, Unsaturated ... G13.540.500 Linoleic Acid D2.241.81.436.390.500 Linoleic Acids D2.241.81.436.390 Linolenic Acids D2.241.81.436.410 Lipotropin ... G5.310.725.124 Amino Acid Motifs G5.331.599.56.40 G6.184.603.60.40 G6.184.599.56.40 Amino Acid Sequence G5.331.599.56 G6.184. ... L1.453.245.100 Acetic Acid D2.241.81.465.92.129 Acetic Acids D2.241.81.465.92 Aconitine D3.132.26.30 D3.132.30 Actinomyces ...
DeCS
A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; ... A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; ... Arachidonic Acids (1967-1989). Fatty Acids, Unsaturated (1973-1989). Leukotrienes (1989). Prostaglandins (1966-1989). ... LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors ...
Arachidonic Acid2
- It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a). (bvsalud.org)
- Nordihydroguaiaretic acid (NDGA), a dicatechol and phytochemical polyphenolic antioxidant and an established inhibitor of human arachidonic acid (AA) 5-lipoxygenase (LOX) and 15-LOX, is widely used to ascertain the role of LOXs in vascular endothelial cell (EC) function. (bvsalud.org)
ETYA2
- ETYA, 5,8,11,14-eicosatetraynoic acid) were studied in an isolated preparation of ductus arteriosus from mature foetal lambs. (nih.gov)
- however, their action was abolished by pretreatment of the tissue with the cyclooxygenase inhibitor indomethacin (2.8 x 10(-6) M). Indomethacin-treated preparations were also unresponsive to ETYA 3 x 10(-5) M. The contraction of hypoxic tissues to either BW755C or FPL55712 increased further upon raising the oxygen tension of the medium (PO2 591--691 Torr). (nih.gov)
20231
- 18(8): 1891-1904, 2023 08 18. (bvsalud.org)
Arachidonic acid1
- It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a). (nih.gov)
Inhibition2
- Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. (medscape.com)
- Preincubation of hypothalamic explants with dexamethasone, indomethacin (1 microM), eicosatetraynoic acid (10 microM), or nordihydroguaiaretic acid (30 microM) resulted in inhibition of TNF alpha-stimulated CRH secretion (P less than 0.05). (nih.gov)
Phosgene1
- In case of asymptomatic patients with suspected exposure to phosgene, monitor the patient for a minimum of 8-12 hours (many authors recommend 12-24 h[1] ) because of the potential for delayed-onset pulmonary edema. (medscape.com)