5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).Masoprocol: A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.Lipoxygenase: An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.Lipoxygenase Inhibitors: Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.Arachidonic AcidsArachidonic Acid: An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine: A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.SRS-A: A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)Fatty Acids, Unsaturated: FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.Arachidonate Lipoxygenases: Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are then rapidly converted by a peroxidase to hydroxyeicosatetraenoic acids. The positional specificity of the enzyme reaction varies from tissue to tissue. The final lipoxygenase pathway leads to the leukotrienes. EC 1.13.11.- .Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.Prostaglandins: A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.Prostaglandins E: (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.Blood Patch, Epidural: The injection of autologous blood into the epidural space either as a prophylactic treatment immediately following an epidural puncture or for treatment of headache as a result of an epidural puncture.Cyclooxygenase Inhibitors: Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Animals, Newborn: Refers to animals in the period of time just after birth.Cerebellum: The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.Lateral Ventricles: Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.L-Selectin: Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Cell Adhesion: Adherence of cells to surfaces or to other cells.Leukocyte Rolling: Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Eicosanoids: A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).Seed Dispersal: The various physical methods which include wind, insects, animals, tension, and water, by which a plant scatters its seeds away from the parent plant.Geraniaceae: A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.Body Temperature: The measure of the level of heat of a human or animal.Eicosanoic Acids: 20-carbon saturated monocarboxylic acids.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Prostaglandin-Endoperoxide Synthases: Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.Peroxisome Proliferator-Activated Receptors: TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.PPAR gamma: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.PPAR alpha: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.Thiazolidinediones: THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).Larrea: A plant genus of the family ZYGOPHYLLACEAE. It is sometimes called chaparral but that is a generic word which is used with a number of other plants. Members contain NORDIHYDROGUAIARETIC ACID.Rhamnaceae: The buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.ColombiaLignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Artemisia: A plant genus of the family ASTERACEAE with strong-smelling foliage. It is a source of SANTONIN and other cytotoxic TERPENES.Pseudomonadaceae: A family of gram-negative bacteria usually found in soil or water and including many plant pathogens and a few animal pathogens.Acetobacteraceae: A family of gram-negative aerobic bacteria consisting of ellipsoidal to rod-shaped cells that occur singly, in pairs, or in chains.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Polyenes: Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
... oleic acids MeSH D10.251.355.325.600.525 --- oleic acid MeSH D10.251.355.325.600.780 --- ricinoleic acids MeSH D10.251.355.325. ... fatty acids, omega-6 MeSH D10.251.355.343.249 --- gamma-linolenic acid MeSH D10.251.355.343.500 --- linoleic acids MeSH D10.251 ... gamma-linolenic acid MeSH D10.251.355.840 --- sorbic acid MeSH D10.251.355.920 --- trans fatty acids MeSH D10.251.400.092 --- ... linoleic acid MeSH D10.251.355.310.640 --- linolenic acids MeSH D10.251.355.310.640.400 --- alpha-linolenic acid MeSH D10.251. ...
Calbiochem CAS 1191-85-1 Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl ... Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases.. More,, ... Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. ... Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A2 ( ...
... neurons requires loss of PIP2 and generation of a free fatty acid, probably arachidonic acid (AA) by phospholipase A2 (PLA2). ... Fatty acid release and L-current inhibition by Oxo-M are lost in SCG neurons lacking cPLA2. If M1R modulation of L-current ... A, Examples of fatty acid fluorescence in sPLA2−/− and in s/cPLA2−/− mouse SCG neurons. Con, 0 min of stimulation; Oxo-M, 6 min ... 2000) Arachidonic acid modulation of α1H, a cloned human T-type calcium channel. Am J Physiol Heart Circ Physiol 278:H184-H193. ...
... except that the formic acid pretreatment was omitted. BrdUrd stained sections then were immunostained for various neural cell ... 5), including the Islands of Calleja (16) in the ventral forebrain and the subependyma of the olfactory bulb (17, 18). A large ... Figure 5 Localization of BrdUrd-labeled MSCs in neural rich regions of forebrain. (A) Low magnification of forebrain showing ... Azizi et al. (8) infused rat brains with human marrow stromal cells (MSCs) that are capable of expansion, self-renewal, and ...
9163568 - The effect of 5,8,11,14-eicosatetraynoic acid on endothelial cell gene expression.. 9780218 - Endothelial selectins ...
Takami M, Preston SL, Behrman HR. Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via ... Brock TG. Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. ... Cardoso CM, De Meis L. Modulation by fatty acids of Ca2+ fluxes in sarcoplasmic-reticulum vesicles. Biochem J 296: 49-52, 1993. ... Huang JK, Chen WC, Huang CJ, Hsu SS, Chen JS, Cheng HH, Chang HT, Jiann BP, Jan CR. Nordihydroguaiaretic acid-induced Ca2+ ...
PEA was identified in 1957 as a fatty acid amide with anti-inflammatory properties (Kuehl et al., 1957). While PEA is a known ... Taylor, B. K. (2013). N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia. Pain 154, 326-327 ... Chemokine ligands are grouped into four families based on their amino acid sequence: alpha (CXC), beta (CC), gamma (C), and ... Specifically, 15d-PGJ2 and troglitazone inhibited TNFα expression in monocytes stimulated by okadaic acid or phorbol ester but ...
Galbraith, H., and Miller, T. B., 1973b, Effect of long chain fatty acids on bacterial respiration and amino acid uptake, J. ... XI. Relationship between stimulated oxidative metabolism and hydrogen peroxide formation, and intracellular killing, J. ... Dubos, R. J., 1950, The effect of organic acids on mammalian tubercle bacilli, J. Exp. Med. 42:319.CrossRefGoogle Scholar ... Canfield, R. E., 1963, The amino acid sequence of egg white lysozyme, J. Biol. Chem. 238:2698.PubMedGoogle Scholar ...
PAR2 stimulation induces release of arachidonic acid and PGE2 from epithelial cells (Kong et al., 1997), and these mechanisms ... whereas bradykinin transactivates TRPV1 through the generation of 12-lipoxygenase metabolites of arachidonic acid (Shin et al ... 5a-c). The PKC inhibitor GFX (1 μm, 5 min) abolished the potentiation of the TRPV1 current induced by PAR2-AP (1.1-± 0.2-fold ... 8a). In TRPV1+/+ mice, intraplantar injection PAR2-AP but not PAR2-RP (1 μg/paw) also caused a sustained decrease in latency of ...
... known as nordihydroguaiaretic acid (NDGA) is a potent antioxidant and was thought by some scientists to be a potential cancer ... 7. Salari H, Braquet P, Borgeat P. Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid ... Clinical experience with nordihydroguaiaretic acid-"chapparel tea" [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39 ... Clinical experience with nordihydroguaiaretic acid-"chapparel tea" [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39 ...
Infusing arachidonic acid increased thromboxane synthesis to the same extent in phosgene-exposed lungs as in control lungs; ... a nonmetabolized competitive inhibitor of arachidonic acid metabolism, or the leukotriene receptor blockers, FPL 55712 and LY ...
The Bcl3-RXRα interaction is influenced by the presence of 9-cis-retinoic acid (38), whereas ligand does not appear to be ... Briefly, human ERRα cDNA corresponding to the ligand-binding domain (amino acids 197 to 422) was cloned into pAS2-1 vector and ... Taken together, these results identify at least two Bcl3 interacting regions within amino acids 359 to 403 and 144 to 359 of ... The numbers correspond to amino acid positions. Bacterially expressed GST, GST-ERRα, or GST-Bcl3 fusion proteins were used with ...
... oleic acids MeSH D10.251.355.325.600.525 --- oleic acid MeSH D10.251.355.325.600.780 --- ricinoleic acids MeSH D10.251.355.325. ... fatty acids, omega-6 MeSH D10.251.355.343.249 --- gamma-linolenic acid MeSH D10.251.355.343.500 --- linoleic acids MeSH D10.251 ... gamma-linolenic acid MeSH D10.251.355.840 --- sorbic acid MeSH D10.251.355.920 --- trans fatty acids MeSH D10.251.400.092 --- ... linoleic acid MeSH D10.251.355.310.640 --- linolenic acids MeSH D10.251.355.310.640.400 --- alpha-linolenic acid MeSH D10.251. ...
... lactic acid, malic acid, citric acid, glycolic acid, mandelic acid, tartaric acid, glyceric acid or ascorbic acid or the salts ... eicosatetraynoic or 5,8,11 -eicosatrynoic acid or an ester or an amide thereof, and combinations thereof. ... azelaic acid, caffeic acid or kojic acid; emollients; hydrating or moisturizing agents such as glycerol, PEG 400, ... By the term "amino acid residue" is particularly intended a residue derived from lysine, from glycine or from aspartic acid, ...
Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ... Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ... Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ... Cytolysis of many cell types is mediated by arachidonic acid (AA) and its generation by phospholipases is regulated by G- ...
Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR. Hypertension. 2001 Jan 1;37(3):887 ... Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR. / Pomposiello, Silvia I.; Carroll ... title = "Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR", ... T1 - Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR ...
In vitro effects of arachidonic acid and of inhibitors of its metabolism on the dog thyroid gland.. ... Effects of arachidonic acid on the thyroid gland in vitro. par Boeynaems, Jean-Marie , Van Sande, Jacqueline , Gervy Decoster, ... In vitro effects of arachidonic acid and of inhibitors of its metabolism on the dog thyroid gland. ...
13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three ... 15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5, ... Fatty Acids, Nonesterified (0) * Fatty Acids, Unsaturated (0) * Arachidonic Acids (0) * Eicosanoids (1) * Arachidonic Acids (0) ...
Fatty Acids) [FA] are a diverse group of molecules synthesized by chain elongation of an acetyl-CoA primer with malonyl-CoA (or ... "Fatty Acids (Fatty acyls)" [FA] Fatty Acid. In our body, Fatty Acids are aliphatic acids fundamental to energy production, ... Hydroperoxy Fatty Acids [FA0104] *Hydroxy Fatty Acids [FA0105] *Oxo Fatty Acids [FA0106] *Epoxy Fatty Acids [FA0107] *Methoxy ... Halogenated Fatty Acids [FA0109] *Amino Fatty Acids [FA0110] *Cyano Fatty Acids [FA0111] *Nitro-Fatty Acids [FA0112] *Thia ...
Inhibition by eicosatetraynoic acid (ETYA) was more persistent. These results are consistent with previous reports that SHAM ... Salicylhydroxamic acid (SHAM) and 3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride (BW755C) delayed the response ... The hypothesis that arachidonic acid (AA) induction of sesquiterpene accumulation and browning in potato (Solanum tuberosum) is ... Inhibition by Salicylhydroxamic Acid, BW755C, Eicosatetraynoic Acid, and Disulfiram of Hypersensitive Resistance Elicited by ...
Apoptosis , Cell Death , Cell Survival , DNA Fragmentation , Egtazic Acid , Flufenamic Acid , Genes, myc , Genes, p53 , ... Treatment with either ursodeoxycholic acid (UDCA) or lithocholic acid (LCA) resulted in a dose- and time-dependent decrease in ... Arachidonic Acid , Arachidonic Acids , Cytosol , Ethylmaleimide , Hep G2 Cells , Hepatoblastoma , Humans , Indomethacin , ... Apoptosis , Bile Acids and Salts , Bile , Calcimycin , Calcium , Carcinoma, Hepatocellular , Cell Death , Cell Survival , ...
Amino Acid Sequence , Amino Acid Substitution , Animals , Azides/chemistry , Binding, Competitive , Cell Membrane/metabolism , ... Amino Acid Transport Systems , Amino Acids/metabolism , Animals , Anions , Carrier Proteins/metabolism , Culture Techniques , ... Arachidonic Acid , Arachidonic Acids , Cytosol , Ethylmaleimide , Hep G2 Cells , Hepatoblastoma , Humans , Indomethacin , ... Although neutral amino acids weakly inhibited the uptake of L-glutamate, there was no evidence for the heterogeneity of anionic ...
N-Acetylneuraminic acid, N-acetylated hexosamines, glucose, galactose, and xylitol were likewise well separated from each other ... and clofibric acid all directly induced mPPARalpha conformational changes as evidenced by a differential protease sensitivity ... In the 5 loading conditions, it was found that when the crown was loaded with vertical concentrated load, the tensile stresses ... A 0.5 g whole blood sample, 5 microL naphthalene, fluorene, and anthracene (50 microg/mL) as spiked standards, and 0.5 mL ...
Results: Results showed that the induction of different formulations of humic acid, citric acid, and chitosan had significant ... Conclusion: The use of biostimulants formulation including humic acid, citric acid, and chitosan had a significant positive ... Treatments consisted of: control, citric acid, different concentrations of humic acid, dual combinatorial formulations of ... chitosan and citric acid, and triple combinatorial formulations of chitosan, citric acid, and humic acid. First, the roots of ...
12 o tetradecanoylphorbol 13 acetate but not 12 o retinoylphorbol 13 acetate and inhibition of the clastogenic effects by 4 8 ... Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by ... and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate. Cancer Research 47(24 Pt 1): 6633-6638, 1987 ... Carcinogenesis 8(1): 191-192, 1987. Inhibition by indomethacin and 5,8,11,14-eicosatetraynoic acid of the induction of rat ...
Eicosatetraynoic acid (ETYA 1, U53119) inhibited AA conversion by the LO pathway, whereas 5,8,11,14-eicosatetraynoic acid (ETYA ... Nicotinic acid: current status in lipid management and cardiovascular disease prevention.. In addition, B700 has partial ...
  • Inhibits cyclooxygenase (ID 50 = 8 µM), 5-lipoxygenase (ID 50 = 10 µM), 12-lipoxygenase (ID 50 = 300 nM), and 15-lipoxygenase (ID 50 = 200 nM) in whole cells. (emdmillipore.com)
  • Creating conditions similar to those that occur during exposure of cells to microgravity induced a sixfold increase of apoptotic bodies and DNA fragments in human lymphocytes, paralleled by an early (within 2 h) fourfold increase in 5-lipoxygenase (5-LOX) activity and a fivefold decrease in mitochondrial membrane potential and increase in cytochrome c release (within 4 and 8 h, respectively). (uniss.it)
  • Fatty Acids (Fatty acyls) and the conjugates and derivatives of these Fatty Acids, are a class of lipids synthesized by chain-elongation of an acetyl-CoA primer with malonyl-CoA or methylmalonyl-CoA groups through the fatty acid synthesis process. (wellnessadvantage.com)
  • In lipid science , a Fatty Acid is an organic carboxylic acid , with a long unbranched aliphatic tail (chain), which my either be saturated or unsaturated. (wellnessadvantage.com)
  • In our diet and in our body, Eicosanoids are a class of fatty acid compounds named after and generally derived from C20 fatty acids, that have hormone-like effects ( autacoid effects , mediated by specialized eicosanoid receptors ). (wellnessadvantage.com)
  • In lipid science, four families of the unsaturated fatty acid Eicosanoids are the prostaglandins, prostacyclins, the thromboxanes and the leukotrienes. (wellnessadvantage.com)
  • The present invention relates to novel uridine esters of the general formula ##STR00001## wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R' represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. (patents.com)
  • The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination. (patents.com)
  • To describe precisely the structure of a fatty acid molecule, one must give the length of the carbon chain (number of carbon atoms), the number of double bonds and also the exact position of these double bonds. (patentgenius.com)
  • Besides 12( S )-HETE, other LO metabolites, particularly the 5-LO products (5-HETEs), have been implicated in cancer development. (aacrjournals.org)
  • Similar membrane potential and cytochrome c release were observed in isolated mitochondria treated with physiological amounts of 5-LOX and were enhanced by creating conditions similar to those that occur during exposure of cells to microgravity. (uniss.it)
  • The intracellular calcium chelator EGTA-acetoxymethylester reduced 5-LOX activity and apoptosis to 30-40% of controls, whereas the p38 mitogen-activated protein kinase inhibitor SB203580 was ineffective. (uniss.it)
  • Finally, creating conditions similar to those that occur during exposure of cells to microgravity did not induce apoptosis in human lymphoma U937 cells, which did not express an active 5-LOX. (uniss.it)
  • Eicosanoids derived from the arachidonic acid cascade have been implicated in the pathogenesis of a variety of human diseases, including cancer, and are now believed to play important roles in tumor promotion, progression, and metastatic disease. (aacrjournals.org)
  • Many cell types can use either glucose or fatty acids for this purpose. (wellnessadvantage.com)
  • N-Acetylneuraminic acid, N-acetylated hexosamines, glucose, galactose, and xylitol were likewise well separated from each other under isocratic elution conditions. (statescale.tk)
  • Improvement kojic acid production ability of A. terreus by random mutagenesis using different exposure time to ultraviolet light (5-40 min) was then performed to obtain a suitable mutant of kojic acid production (designated as C5-10, 7.63 g/L). Thereafter, design of experiment protocol was employed to find medium components (glucose, yeast extract, KH2PO4 (NH4)2SO4, and pH) influences on kojic acid production by the C5-10 mutant. (bvsalud.org)
  • SUMMARY: Earlier studies on the fermentation of D-[1- 14 C]- and D-[3,4- 14 C]glucose by Lactobacillus divergens showed that lactate was the major fermentation product and that it was probably produced by glycolysis. (microbiologyresearch.org)
  • Results obtained with D-[U- 14 C]glucose showed that approximately three-quarters of the lactate but less than 10% each of the formate and acetate were produced from glucose. (microbiologyresearch.org)
  • In one model, M 1 -muscarinic receptors (M 1 Rs) may inhibit both Ca 2+ (L- and N-) and K + (M-) currents by losing a putative interaction between channels and phosphatidylinositol-4,5-bisphosphate (PIP 2 ). (jneurosci.org)
  • The nuclear receptor superfamily of transcription factors regulate the expression of genes involved in multiple cellular processes including metabolism, growth, differentiation, and inflammation ( 6 , 14 , 42 ). (asm.org)
  • In our body, the biosynthesis of Octadecanoids [FAare involved with the metabolism of Linoleic Acid (LA) . (wellnessadvantage.com)
  • 8 ) infused rat brains with human marrow stromal cells (MSCs) that are capable of expansion, self-renewal, and differentiation into multiple mesenchymal cell lineages ( 9 , 10 ). (pnas.org)
  • Treatments consisted of: control, citric acid, different concentrations of humic acid, dual combinatorial formulations of chitosan and citric acid, and triple combinatorial formulations of chitosan, citric acid, and humic acid. (bvsalud.org)
  • For in vivo transplantation experiments, MSC cultures grown for 5 days were pulsed for 48 hr with 5 μM 5-bromo-2-deoxyuridine (BrdUrd) (Sigma) in α-MEM (Eagle's minimal essential medium) supplemented with 10% FBS or for 24 hr with 10 μg/ml bis-benzimide (Sigma) before harvest. (pnas.org)
  • ABSTRACT The ability of four Aspergillus strains for biosynthesis of kojic acid was evaluated among which Aspergillus terreus represented the highest level (2.21 g/L) of kojic acid production. (bvsalud.org)
  • Oct. 1996) vol. 10, No. 5, pp. 280-287) (Abstract Sent). (patents.com)
  • In our body, Fatty Acids are aliphatic acids fundamental to energy production, energy storage, cellular structure and as intermediates in the biosynthesis of hormones and other biologically important molecules, synthesized by a series of decarboxylative claisen condensation reactions from acetyl-CoA and malonyl-CoA. (wellnessadvantage.com)
  • This model is supported by our findings that exogenously applied arachidonic acid (AA) mimicked muscarinic agonists and that antagonizing PLA 2 with oleyloxyethyl phosphorylcholine (OPC) or limiting free endogenous AA minimized whole-cell N-current modulation ( Liu and Rittenhouse, 2003 ). (jneurosci.org)
  • We used two tests of analgesia (the acetic acid writhing test and the hot-water tail-flick test) and selective kappa agonists and antagonists given at supraspinal and spinal sites in mice. (propecia2020.site)
  • Conclusion: The use of biostimulants formulation including humic acid, citric acid, and chitosan had a significant positive effect on improving vegetative characteristics and especially on phytochemical traits of catnip [Nepeta cataria L. (bvsalud.org)
  • Stem cells also have been identified in the gut, gonads, skin, and brain of adults ( 5 , 6 ). (pnas.org)
  • showed that neural stem cells differentiated into myeloid and lymphoid cell lineages after transplantation into the hematopoietic system of irradiated hosts ( 11 ). (pnas.org)
  • Cells were harvested by incubating with 0.25% trypsin for 5 min at room temperature followed by gentle scraping. (pnas.org)
  • Human limb muscles can attain temperatures up to 41°C during intense exercise in hot ambient environments, ( 45 ) and rat limb muscle temperature has been measured as high as 44°C during exhaustive exercise ( 11 ). (physiology.org)
  • Taken together, these data imply that LO products, particularly those of 5- and 12-LO, may play important roles in modulating cancer development. (aacrjournals.org)
  • The commonly used AMPK activators include 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and A-769662. (bvsalud.org)
  • The HIVconsv vaccines have entered 8 clinical trials and showed high immunogenicity in HIV-negative adults in Oxford and Kenya as well as in HIV-infected patients on antiretroviral treatment. (ox.ac.uk)
  • Starting in 1964, and continuing for fourteen years, the Research Council arranged for a presentation by some of thevery best basic scientists that could be found. (medicinelakex1.com)
  • Salicylhydroxamic acid (SHAM) and 3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride (BW755C) delayed the response to AA. (semanticscholar.org)
  • and KH2PO4, 10.3 mM which was theoretically able to produce 120.2 g/L of kojic acid based on the obtained response surface model for medium optimization. (bvsalud.org)
  • The study focuses on the importance of Tyr11 amino acid (AA) and subsequent stereochemistry involved in the binding process of neurotensin (NT) with its receptor (NTR)/binding protein(s) as well as the size heterogeneity. (bvsalud.org)