Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.
Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.
Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Decarboxylated monoamine derivatives of TRYPTOPHAN.
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
Injections into the cerebral ventricles.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
The observable response an animal makes to any situation.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.
5,7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Farzam, Ali; Chohan, Karan; Strmiskova, Miroslava; Hewitt, ... Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic ...
5,7-Dihydroxytryptamine MPTP Oxidopamine Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2- ... 5 (7): 1925-1933. doi:10.1523/jneurosci.05-07-01925.1985. PMC 6565098. PMID 3926960. Jaim-Etcheverry G, Mari'a Zieher L (1980 ...
... , also known as 4-HO-5-MeO-DMT or psilomethoxin, is a novel psychedelic drug. It is the 4- ... Though this method has never been explored with 5-MeO-DMT, it has been used successfully for changing DET into 4-HO-DET and 4- ... This paper reports a 10 step synthesis of 4-HO-5-MeO-DMT from ortho-vanillin. However, Alexander Shulgin has explained that it ... XIV (*) - Sur des méthoxy-5 hydroxy-4, méthoxy-5 hydroxy-6 et méthoxy-7 hydroxy-6 tryptamines]". Bull Chim Soc Fr (in French): ...
6-dihydroxytryptamine MeSH D03.438.473.914.201.263 - 5,7-dihydroxytryptamine MeSH D03.438.473.914.237 - N,N-Dimethyltryptamine ... 5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
44 (5): 329-335. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143. Fuller, R. W.; Baker, J. C. (1974). "Long-lasting ... Gal, E. M.; Cristiansen, P. A.; Yunger, L. M. (1975). "Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in ... Colado, M. I.; Murray, T. K.; Green, A. R. (1993). "5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), ... Curzon, G; Fernando, J. C.; Marsden, C. A. (1978). "5-Hydroxytryptamine: The effects of impaired synthesis on its metabolism ...
... (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... 9 (5): 879-888. doi:10.3390/md9050879. PMC 3111189. PMID 21673896.. *^ Jin-Feng Hu; John A. Schetz; Michelle Kelly; Jiang-Nan ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges Smenospongia ...
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5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a ... It may have anti-anxiety and anti-depressant effects.[6][7] Religious use[edit]. The Church of the Tree of Life, founded in ... "5-MeO-DMT Timeline". Erowid.. *^ Krebs-Thomson K, Ruiz EM, Masten V, Buell M, Geyer MA (December 2006). "The roles of 5-HT1A ...
6-dihydroxytryptamine in rats". Research Communications in Chemical Pathology and Pharmacology. 8 (1): 29-44. PMID 4847904. " ... 23 (5): 627-634. doi:10.1037/a0015568. PMC 2808210. PMID 19702416. Saults, J. S.; Cowan, N.; Sher, K. J.; Moreno, M. V. (2007 ... 14 (5): 1066-1074. doi:10.1111/j.1467-7687.2011.01060.x. PMC 3177168. PMID 21884322. Cowan, N.; Ricker, T. J.; Clark, K. M.; ... 143 (5): 1806-1836. doi:10.1037/a0036814. PMC 4172497. PMID 24867488. Cowan, N.; Li, D.; Moffitt, A.; Becker, T. M.; Martin, E ...
6-dihydroxytryptamine on tyrosine-hydroxylase activity in central catecholaminergic neurons of the rat". Biochemical ... TMEM155 isoform 5 is the longest mRNA and is 2,429 bp long. The shortest isoform is variant 4 and this variant is 2,035 bp long ... These enhancer sites come on the 5' end of the TMEM155 gene and contain binding sites for transcription factors RCOR1, MILLT1, ... This gene spans from base pairs 121,758,930 and 121,765,427 on chromosome 4. The longest variant ofTMEM155 has 5 exons detailed ...
Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substituted benzofurans, MDAI, MDMA). ... InChI=1S/C18H26N2O2/c1-12(2)20(13(3)4)10-9-15-11-19-16-7-6-8-17(18(15)16)22-14(5)21/h6-8,11-13,19H,9-10H2,1-5H3 ... InChI=1/C18H26N2O2/c1-12(2)20(13(3)4)10-9-15-11-19-16-7-6-8-17(18(15)16)22-14(5)21/h6-8,11-13,19H,9-10H2,1-5H3 ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-HT6. *Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline ... Rizatriptan acts as an agonist at serotonin 5-HT1B and 5-HT1D receptors.[11] Like the other triptans sumatriptan and ...
Retrieved 5 June 2013.. *^ Guardiola-Lemaître B (December 1997). "Toxicology of melatonin". Journal of Biological Rhythms. 12 ( ... 90 (5): 2755-61. doi:10.1210/jc.2004-2062. PMID 15713707.. *^ Burkhart K, Phelps JR (26 December 2009). "Amber lenses to block ... 1-7. ISBN 9781587631702. PMC 4781368. PMID 15635761.. *^ Filadelfi AM, Castrucci AM (May 1996). "Comparative aspects of the ... Retrieved 5 June 2013.. *^ Mills E, Wu P, Seely D, Guyatt G (November 2005). "Melatonin in the treatment of cancer: a ...
5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
5-HT2C. Agonists: Phenethylamines: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • ... 5-HT5B*. Agonists: Lysergamides: Ergotamine • LSD. Antagonists: Metitepine/Methiothepin. * Note that the 5-HT5B receptor is not ... 5-HT7. Agonists: Lysergamides: LSD; Tryptamines: 5-CT • 5-MT; Others: 8-OH-DPAT • AS-19 • Bifeprunox • LP-12 • LP-44 • ... 5-HT2A. Agonists: Lysergamides: ALD-52 • Ergonovine • Lisuride • LA-SS-Az • LSD • Lysergic acid 2-butyl amide • Methysergide; ...
6-dihydroxytryptamine: RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the molecular ... 6-dihydroxytryptamine RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the molecular ... 7-methyl-5,6-dihydroxytryptamine. Subscribe to New Research on 7-methyl-5, ...
5,7-dihydroxytryptamine conjugated with carrier protein. (PAB0054) - Products - Abnova ...
Kuhn, C. M., Vogel, R. A., Mailman, R. B., Mueller, R. A., Schanberg, S. M., & Breese, G. R. (1981). Effect of 5,7- ... dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology, 73(2), 188-193. ... Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. / Kuhn, Cynthia M.; ... The 5-HTP-induced changes include elevation of serum prolactin decrease in operant responding, and the magnitude of the " ...
6-dihydroxytryptamine creatinine - Similar structures search, synonyms, formulas, resource links, and other chemical ... 6-dihydroxytryptamine creatinine. RN: 133983-26-3. InChIKey: DPIHOKBTEPDNAI-UHFFFAOYSA-N. Note. *. Tool for the study of the ... 2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one compd. with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ... 1S/C10H10F2N2O2.C4H7N3O.H2O4S/c11-6-5-4(1-2-13)3-14-8(5)7(12)10(16)9(6)15;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h3,14-16H,1-2,13H2;2H2, ...
5,7-DHT produced equivalent, dose-related depletion of hippocampal norepinephrine in both age groups. Since the effects of 5,7- ... These latter results suggest that it is the A form of MAO that plays an important role in the mechanism of 5,7-DHT-induced ... Finnegan, K. T., DeLanney, L. E., Irwin, I., Ricaurte, G. A., & William Langston, J. (1989). The amine-depleting effects of 5,7 ... 5,7-DHT produced equivalent, dose-related depletion of hippocampal norepinephrine in both age groups. Since the effects of 5,7- ...
wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to ... wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to ... Following three weeks pretreatment with 5,7-dihydroxytryptamine (20 microg total dose) or vehicle (0.1% ascorbic saline; 2 ... wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine.. ...
keywords = "5,7-dihydroxytryptamine (5,7-DHT), Neuropeptide, serotonin depletion",. author = "Y. Kondo and N. Ogawa and M. ... Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain. Journal of ... Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain. / Kondo, Y ... The level of each neuropeptide except dynorphin significantly increased in specific regions of the brain after 5,7-DHT ...
The lesions reduced the concentration of 5-HT (-90%) and the accumulation (-80%) as well as the evoked release (-90%) of [3H]5- ... 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat ... 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat ... They also decreased the inhibitory effects of CP-93,129 on the evoked release of [3H]5-HT. Most interestingly, they facilitated ...
2C7-DIHYDROXYTRYPTAMINE%20ON%20SEROTONERGIC%20CONTROL%20OF%20PROLACTIN%20SECRETION%20AND%20BEHAVIOR%20IN%20RATS&rft.date=1981& ... EFFECT OF 5,7-DIHYDROXYTRYPTAMINE ON SEROTONERGIC CONTROL OF PROLACTIN SECRETION AND BEHAVIOR IN RATS. Author. KUHN CM; VOGEL ... "O:13:PanistOpenUrl:36:{s:10:\u0000*\u0000openUrl;N;s:6:\u0000*\u0000idc;N;s:6:\u0000*\u0000fmt;s:7:journal; ... "O:12:IstexOpenUrl:35:{s:10:\u0000*\u0000openUrl;N;s:6:\u0000*\u0000fmt;s:7:journal;s:6:\u0000*\u0000doi;s:0 ...
Potentiation in phencyclidine-induced serotonin-mediated behaviors after intracerebroventricular administration of 5,7- ... dihydroxytryptamine in rats. Toshitaka Nabeshima, K. Yamaguchi, K. Ishikawa, H. Furukawa, T. Kameyama ... 7-dihydroxytryptamine in rats. Together they form a unique fingerprint. * Sort by ... Potentiation in phencyclidine-induced serotonin-mediated behaviors after intracerebroventricular administration of 5, ...
Rotation of individual dendritic trees from their normal orientation produced a dramatic 4-5-fold increase in the number of ... 5,7-dihydroxytryptamine (5,7-DHT). A subpopulation of large, weakly fluorescing neurons were identified as composing a single, ... ranges from 60 cells/mm2 near the area centralis to 5 cells/mm2 in the far retinal periphery. A coverage factor (density x ... alpha cell occupy distinct strata within sublamina a of the inner plexiform layer separated by a gap of about 5 microns. The ...
7-OH-PIPAT. R-(+)-trans-7-hydroxy-2-(N-n-propyl-N-3′-iodo-2′-propenyl)aminotetralin. NCQ 298. S-3-iodo-N-[(1-ethyl-2- ... 7-OH-DPAT. 7-hydroxy-n,n-dipropyl-aminotetralin. 6-OHDA. 6-hydroxydopamine. 5,7-DHT. 5,7-dihydroxytryptamine. 5-HT. 5- ... 125I]7-OH-PIPAT bound in a saturable and reversible manner and exhibited subnanomolar affinity for a single population of GTP- ... 5,7-Dihydroxytryptamine lesion of serotonergic cells and processes produced no changes in [125I]7-OH-PIPAT binding. These ...
5,7-Dihydroxytryptamine / pharmacology. Animals. Arginine Vasopressin / blood. Blood Pressure / drug effects. Cardiac Output / ... Partial depletion of neuronal serotonin (after p-chlorophenylalanine or 5,7-dihydroxytryptamine treatment) had no effect on ... or lateral ventricle in doses that were 7-10% of the critical i.v. dose, but had no effect when injected into the spinal ... 7-Dihydroxytryptamine; 361-37-5/Methysergide; 50-67-9/Serotonin; 60634-51-7/LY 53857; 7424-00-2/Fenclonine; EC 3.4.23.15/Renin ...
5.. Synthesis of ion-imprinted polymer-decorated SBA-15 as a selective and efficient system for the removal and extraction of ... 7.. Association of TNF-α -308G,A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer - a Systematic Review ... Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?. Farahani S, Nasirinezhad F, Danyali S, ...
Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. The ... Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. The ... 5-HTP), can induce a behavioral syndrome characterized by rigidity, splayed feet, tremor, head weaving, salivation and forepaw ... 5-HTP), can induce a behavioral syndrome characterized by rigidity, splayed feet, tremor, head weaving, salivation and forepaw ...
The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. Serotonin- ... Retzius cells retain functional membrane properties following ablation by the neurotoxin 5,7-DHT ... leech; Retzius cell; serotonin; 5-hydroxytryptamine; 5,7-dihydroxytryptamine; ablation; glyoxylic acid; fluorescence. ... 7-DHT treatment. However, these brown, mis-shapen, non-fluorescent neurons retain their synaptic inputs, action potentials, ...
7-Dihydroxytryptamine in the Dorsal Raphe Nuclei of Mice, An Immunological Model for Heterotopic Heart and Cardiac Muscle ... Elimination of Serotonergic Neurons by Stereotaxic Injection of 5, ... Elimination of Serotonergic Neurons by Stereotaxic Injection of 5,7-Dihydroxytryptamine in the Dorsal Raphe Nuclei of Mice. ... Yee-Shuan Lee1, Siliang Wu2, Treena Livingston Arinzeh3, Mary Bartlett Bunge1,4,5 ...
5,7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Farzam, Ali; Chohan, Karan; Strmiskova, Miroslava; Hewitt, ... Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic ...
Segal M (1986) 5,7-Dihydroxytryptamine modifies excitability of rat dorsal raphe serotonergic neurons in vitro. Neurosci Lett ... Nedergaard S, Flatman JA, Engberg I (1991) Excitation of substantia nigra pars compacta neurones by 5-hydroxy-tryptamine in ... Organotypic slice culture 5,7-Dihydroxytryptamine Dopaminergic neurones Ventral mesencephalon Substantia nigra Rat ... Wuttke W, Hancke JL, Höhn KG, Baumgarten HG (1978) Effect of intraventricular injection of 5,7-dihydroxytryptamine on serum ...
Because 5-HT has been implicated in learning and memory, the present study was undertaken to examine whether MDMA, by damaging ... 5,7-dihydroxytryptamine/desmethylimipramine which produced a near-total reduction of 5-HT and a modest reduction of ... These data suggest that selective damage to the 5-HT system, like that produced by MDMA, is not sufficient to impair memory, ... The latter treatment group was included to assess the effects of larger 5-HT neuronal lesions than are possible with MDMA. Four ...
5,7-Dihydroxytryptamine lesions of crayfish serotonin-containing neurons: effect on the lateral giant escape reaction DL ...
Methylenedioxymethamphetamine (MDMA) and 5,7-dihydroxytryptamine (5,7-DHT) were used as positive controls because both ... Methylenedioxymethamphetamine (MDMA) and 5,7-dihydroxytryptamine (5,7-DHT) were used as positive controls because both ...
Evidence for 5-HT1 binding sites on 5-HT containing neurons in the raphe dorsalis and centralis of the rat brain. Neurochem. ... Characteriezation and radioautography of 3H-LSD by rat brain slices in vitro: the effect of 5-hydroxytryptamine. Eur. J. ... Characteristics of central 5-HT receptors and their adoptive changes following intracerebral 5,7-dihydroxytryptamine ... 7-dihydroxytryptamine and related compounds. In Neurotoxin, Fundamental and Clinical Advances, I.W. Chubb, L.B. Geffen eds, ...
5-HT-depleted rats had significantly higher H-reflex amplitudes compared with control rats (t(74) = 2.31, p = 0.02; Fig. 2A,B ... 5-HT1AR KO mice had smaller motor map areas compared with WT controls. Direct application of the 5-HT1A/7 agonist 8-OH-DPAT to ... The 5-HT1A/7 agonist (R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was used at a concentration of 80 μm (∼0.5 ml ... The 5-HT1A antagonist WAY-100135 maleate salt was used at a concentration of 6 μm (2 μl/injection site, total volume 6 μl) for ...
Intrathecal pretreatment with 5,7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine and NE levels, ... Intrathecal pretreatment with 5,7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine and NE levels, ... 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord. ... NE-evoked release of adenosine was unaffected by 5,7-dihydroxytryptamine but increased by 6-hydroxydopamine. Subcutaneous ...
Dihydroxytryptamine;Neonate rat;Neurotransmitters;Olfactory recognition;Serotonin. Issue Date: Nov-2010. ... Significant difference in the olfactory recognition test was observed during PND5-7; control pups successfully recognized and ...
Previous Document: Immediate and long-term effects of 5,7-dihydroxytryptamine on rat striatal serotonergic neurons meas.... ... 2140-46-7/25-hydroxycholesterol; 4431-00-9/Aurintricarboxylic Acid; 50-81-7/Ascorbic Acid; 60-92-4/Cyclic AMP; 7447-40-7/ ...
A, evaluation of 7-MT, 7-BT, 4-HT, and 5-MN potency for hSERT. The rank order potency for hSERT is 7-MT , 7-BT , 4-HT , 5-MN (K ... A, 7-BT shifts Y95F to the dSERT-like value. K I values: hSERT, 12.8 ± 0.7 μM; dSERT, 1.82 ± 0.04 μM; Y95F, 2.2 ± 0.2 μM. B, ... 7-MT. 7-methyltryptamine. 7-BT. 7-benzyloxytryptamine. NIT. N-isopropyltryptamine. 5-MNIT. 5-methoxy-N-isopropyltryptamine. ... All compounds except 5-HT displayed a 5-fold or greater difference in K I values between hSERT and dSERT as assessed by ...
  • The intracisternal administration of 5,7-dihydroxytryptamine (5,7-DHT) to rats resulted in a potentiated response to 5-hydroxytryptophan (5-HTP) when the animals were tested 30 days later. (elsevier.com)
  • wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine. (cdc.gov)
  • Using adult rats we determined that pharmacological depletion of serotonin (5-HT) via intracerebroventricular administration of 5,7 dihydroxytryptamine resulted in altered movements of the forelimb in a skilled reaching task as well as higher movement thresholds and smaller maps derived using high-resolution intracortical microstimulation (ICMS). (jneurosci.org)
  • Role of serotonin in olfactory recognition was tested by depleting the olfactory bulb serotonin during postnatal day (PND)1- 4 following administration of 5,7-dihydroxytryptamine. (niscair.res.in)
  • Enhancement of clonidine-induced analgesia by lesions induced with spinal and intracerebroventricular administration of 5,7-dihydroxytryptamine. (saladgaffe.tk)
  • The effect of peripherally administered cyproheptadine or reserpine and the administration of 5,7-dihydroxytryptamine (5,7-DHT) in the nucleus raphe dorsalis on the analgesic activity of salmon calcitonin ( sCT ) injected into the lateral ventricle were investigated in male rats. (manchester.ac.uk)
  • Liu J, Chu YX, Zhang QJ, Wang S, Feng J, Li Q. 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats. (thefullwiki.org)
  • The increase in serum prolactin concentration elicited by administration of the serotonergic agonists quipazine or 5-methyxy-N,N-dimethyltryptamine and by the serotonin uptake inhibitor fenfluramine also was potentiated by pretreating rats with 5,7-DHT. (elsevier.com)
  • These data suggest that both serotonergic receptor supersensitivity and the absence of presynaptic uptake sites contribute to the enhanced responses to 5-HTP occurring in rats previously treated with 5,7-DHT. (elsevier.com)
  • Breese, George R. / Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats . (elsevier.com)
  • Age-dependent alterations in hippocampal immunohistochemical localization of glial fibrillary acidic protein and synaptosomal-associated protein were evaluated in female Fischer 344 rats following serotonergic deafferentation with 5,7-dihydroxytryptamine. (cdc.gov)
  • The levels of five neuropeptides (substance-P, somatostatin, cholecystokinin octapeptide, methionin-enkephalin and dynorphin) were examined in the brain and the spinal cord of rats 2 weeks after intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT). (elsevier.com)
  • Rats were treated with saline, MDMA or 5,7-dihydroxytryptamine/desmethylimipramine. (aspetjournals.org)
  • Direct cortical application of the 5-HT 1A/7 agonist 8-OH-DPAT lowered movement thresholds in vivo and increased map size in 5-HT-depleted rats. (jneurosci.org)
  • In rats, electrical stimulation of the dorsal raphe lowered movement thresholds and this effect could be blocked by direct cortical application of the 5-HT 1A antagonist WAY-100135, indicating that serotonin is primarily acting through the 5-HT 1A receptor. (jneurosci.org)
  • CCK-4 (10 −8 M) but not CCK-8 (10 −8 M) can rapidly reduce the affinity and increase the number of the 3 H-spiperone binding sites linked to 5-HT receptors of the dorsal cerebral cortex of rats. (springer.com)
  • Rats that showed the highest withdrawal scores had lower extracellular fluid levels of serotonin (5-HT) compared to rats showing low withdrawal scores. (scirp.org)
  • Rats were randomly allocated to 3 groups: Sham group (n=20), DSP-4 [N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine] group (50mg/kg ip, n=18), and DSP-4+5,7-DHT [5,7-dihydroxytryptamine] group (ip DSP-4 50mg/kg+icv 5,7-DHT 200μg, n=18). (sigmaaldrich.com)
  • In Sham, DSP-4 and DSP-4+5,7-DHT groups, the effects of ip neurotropin (100NU/Kg) on hot-plate latency in rats with no lesion, noradrenergic neuron depletion and both noradrenergic and serotonergic neuronal depletion were studied, respectively. (sigmaaldrich.com)
  • These results demonstrate that 5-HT systems are not directly responsible for the development of the somatic opiate withdrawal syndrome in morphine-dependent rats. (scripps.edu)
  • Behavioral results indicated that all 5,7-DHT-treated rats had significantly higher alcohol preference and consumption than the corresponding sham controls. (elsevier.com)
  • Except in the cerebellum, the 5,7-DHT-treated rats had significantly lower levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in most brain regions compared with those in the corresponding sham controls. (elsevier.com)
  • Treatment with 5,7-DHT also resulted in a decrease in serotonin turnover in all brain regions in the alcohol-free rats, except in the cerebellum. (elsevier.com)
  • In alcohol-drinking rats, however, 5,7-DHT treatment only reduced serotonin turnover in the pons. (elsevier.com)
  • Thus, it appeared that in the Sprague Dawley rats, 5,7-DHT treatment depleted 5-HT and 5-HIAA levels in most brain regions while increasing alcohol consumption. (elsevier.com)
  • One week after stereotaxic infusions of 5,7-dihydroxy-tryptamine (5,7-DHT, 1.6 micrograms) into the right medial forebrain bundle (MFB), rats received [3H]DOPA (200 microCi,i.v.), which circulated for 90 min. (semanticscholar.org)
  • In the following 5 days rats were injected (s.c.) with vehicle, nicotine, or WIN 55,212-2. (plcsignaling.com)
  • Following intraplantar injections of carrageenan , the spinal 5-HT7R expression was examined using Western blotting in male Sprague-Dawley rats . (bvsalud.org)
  • However, it remained significantly higher 1 hour after the injection in the animals treated with 5,7-DHT than in the naive and control rats . (bvsalud.org)
  • In biochemical study it was shown that analgetics employed in this study (with exception of indomethacin) altered synthesis rate of serotonin (5-HT) and dopamine (DA) in the examined parts of the rats brain. (edu.pl)
  • Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. (psychiatryinvestigation.org)
  • The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion. (psychiatryinvestigation.org)
  • Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. (psychiatryinvestigation.org)
  • 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. (psychiatryinvestigation.org)
  • Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY). (psychiatryinvestigation.org)
  • 5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. (psychiatryinvestigation.org)
  • The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation. (psychiatryinvestigation.org)
  • For example, IR rats were found more immobile than their social controls in forced swim test (FST, an acknowledged depression paradigm) [ 7 ], indicating a behavioral despair in which the animal gives up to struggle out of a confined distressing situation [ 8 ]. (psychiatryinvestigation.org)
  • 5. Fink, G., Smith, J.R. & Tibballs, J. (1971) Corticotrophin releasing factor in hypophysial portal blood of rats. (georgefink.com)
  • High-speed chronoamperometry was used to determine the kinetics of clearance of exogenously applied serotonin (5-HT) in the dorsal raphe nucleus (DRN), dentate gyrus, CA3 region of the hippocampus or corpus callosum of anesthetized rats. (uthscsa.edu)
  • In hippocampal regions of intact rats, local application of the selective serotonin reuptake inhibitor, fluvoxamine, inhibited 5-HT clearance most robustly when the extracellular concentration of 5-HT was less than the K T value. (uthscsa.edu)
  • In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor (BDNF), and on circulating leptin levels, of male rats. (biomedcentral.com)
  • The findings further demonstrate that both behavioral and hormonal measures can be used to assess the sensitivity of serotonergic receptors and indicate that 5,7-DHT may be useful in evaluating the role of serotonergic neurons in neuroendocrine function. (elsevier.com)
  • Together our results demonstrate that serotonin, acting through 5-HT 1A receptors, plays an excitatory role in forelimb motor map expression. (jneurosci.org)
  • Taken together the present findings give evidence that neuropeptide receptors and glutamate receptors can in vitro rapidly modulate the characteristics of different types of DA and 5-HT receptors by way of receptor-receptor interactions at the comodulate level or at the local circuit level. (springer.com)
  • Some members of the G protein‐coupled receptor family, specifically several serotonin (5‐HT) receptors, possess eight hydrophobic domains. (deepdyve.com)
  • Lyon, R.A., Glennon, R.A. and Titeler, M. 3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective Interactions at Brain 5- HT1 and 5-HT2 Receptors. (ecstasy.org)
  • Used collectively, these outcomes recommend that the impact of serotonin on adult neurogenesis in the crustacean mind can be CCNE2 family tree reliant, and that 5-HT2 and 5-HT1 receptors underlie these results. (livingseas.org)
  • In arthropods, it is certainly forecasted that at least 18 monoamine receptors can be found [19], and in crustacean types serotonin receptors accounts for 5 or even more of these [20-22]. (livingseas.org)
  • 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors. (psychiatryinvestigation.org)
  • These data indicate that the mechanism of EAA involves opioid receptors, and the serotonergic system, particularly, μ -, δ -opioid and 5-HT 1A , 5-HT 3 receptors and it is also dependent on the EAc frequency. (hindawi.com)
  • β -Endorphin predominantly synthetized in the arcuate nucleus of the hypothalamus has major analgesic effects via μ -, κ -opioid receptors in the periaqueductal gray region [ 5 ]. (hindawi.com)
  • 5-HT1A receptors were quantified by in vitro binding autoradiography. (biomedcentral.com)
  • GR and MR receptors are the molecules mediating the negative feedback control exerted by glucocorticoids on HPA axis function [ 5 ]. (biomedcentral.com)
  • 5,7-Dihydroxytryptamine ( 5,7-DHT ) is a neurotoxin used to selectively kill serotonergic neurons in scientific research, in the same way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells . (thefullwiki.org)
  • Since the effects of 5,7-DHT on noradrenergic neurons may, at leastin part, depend on the monoamine oxidase (MAO)-generated formation of hydrogen peroxide and associated oxy-radicals,this result suggests that noradrenergic neurons do not become more vulnerable to oxidative stress with aging. (elsevier.com)
  • Although the mechanism by whichthis compound damages serotonergic neurons is uncertain, our results show that the increased susceptibility of serotonergic neurons to 5,7-DHT in young animals extends well beyond the neonatal period. (elsevier.com)
  • These results confirm that grafts rich in serotonergic neurons may partially compensate for the dramatic effects of 5,7-DHT lesions on serotonergic hippocampal functions. (univoak.eu)
  • Lesion of dopaminergic neurons with 6-hydroxydopamine produced 50% decreases in [ 125 I]7-OH-PIPAT binding in the nucleus accumbens and substantia nigra. (aspetjournals.org)
  • Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. (wikipedia.org)
  • The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. (caltech.edu)
  • The recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is toxic to central serotonin (5-HT) neurons, but few long-term functional consequences of MDMA neurotoxicity have been identified. (aspetjournals.org)
  • Because 5-HT has been implicated in learning and memory, the present study was undertaken to examine whether MDMA, by damaging 5-HT neurons, altered mnemonic function on a long-term basis. (aspetjournals.org)
  • Immediate and long-term effects of 5,7-dihydroxytryptamine on rat striatal serotonergic neurons meas. (biomedsearch.com)
  • On the functional role of coexistence of 5-HT and substance P in bulbospinal 5-HT neurons. (springer.com)
  • The 5-HT-denervated hippocampus was further found to be a favorable environment for the growth of grafted 5-HT, but not for inrepinephrinergic neurons. (nyu.edu)
  • The trophic extract was assayed in a unique experimental paradigm - test the growth of grafted 5-HT neurons in the cerebellum, which receives the least 5-HT innervation, and where grafted 5-HT neurons have seldom survived. (nyu.edu)
  • The diluted trophic extract (1:200) produced a dramatic increase in (a) the survival rate, (b) the 5-HT fiber-density, and (c) the 5-HT and 5-hydroxyindoleacetic acids lvels of grafted 5-HT neurons in the cerebellum. (nyu.edu)
  • These results indicate that (a) the supernatant in the 5-HT-denervated hippocampus contains a potent neurotrophic factor to 5-HT neurons (b) which can either directly or indirectly also support non-5-HT raphe neurons, and (c) possibly an inhibitory factor is present which is detrimental to 5-HT neurons in high concentration. (nyu.edu)
  • Adult neurogenesis, the creation of functionally integrated neurons in the teen and adult mind, is usually a common feature in a variety of species, from insects and crustaceans to birds and mammals [5]. (livingseas.org)
  • The trophic effects of specific denervation on the growth and survival of fetal serotonergic (5‐HT) or norepinephrinergic (NE) neurons grafted into the hippocampus were assessed by means of two transplantation paradigms. (nyu.edu)
  • In the first, fetal raphe cells (containing 5‐HT neurons) were transplanted into the control hippocampus. (nyu.edu)
  • We found that a month after transplantation, the number of 5‐HT immunoreactive neurons was not significantly different between the two experimental paradigms. (nyu.edu)
  • However, transplanted raphe neurons had 400% more 5‐HT synaptosomal high‐affinity uptake and 380% higher content of 5‐HT in the hippocampus with prior 5,7‐DHT lesion than in control hippocampus. (nyu.edu)
  • Furthermore, immunocytochemistry showed that the transplanted 5‐HT neurons had denser processes and varicosities in the hippocampus with lesion than in control hippocampus. (nyu.edu)
  • A greater 5‐HT level could be achieved if transplanted neurons in the control hippocampus were treated with the supernatant extracted from the hippocampus with 5,7‐DHT lesion. (nyu.edu)
  • In contrast, the NE level of the implanted fetal locus ceruleus (containing NE neurons) was not significantly higher in the 5‐HT denervated hippocampus than in control hippocampus a month after transplantation. (nyu.edu)
  • These results suggest that 5‐HT denervation in the hippocampus induces a trophic substance which promotes the maturation rather than survival of 5‐HT neurons but not NE neurons. (nyu.edu)
  • 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices. (univoak.eu)
  • The lesions reduced the concentration of 5-HT (-90%) and the accumulation (-80%) as well as the evoked release (-90%) of [3H]5-HT. (univoak.eu)
  • The latter treatment group was included to assess the effects of larger 5-HT neuronal lesions than are possible with MDMA. (aspetjournals.org)
  • Because Alzheimer's disease involves impairments in acetylcholine, 5-HT and norepinephrine systems, animals with combined lesions may provide a useful model to study the mnemonic dysfunctions characteristic of this disease. (aspetjournals.org)
  • Brain norepinephrine and dopamine concentration were not affected by 5-HTP in either group of animals. (elsevier.com)
  • A monoamine-accumulating ganglion cell type has been identified in an in vitro preparation of the cat's retina by a catecholamine-like fluorescence that appears following intravitreal injections of dopamine and the indoleaminergic transmitter analog, 5,7-dihydroxytryptamine (5,7-DHT). (nih.gov)
  • On the interaction of 5-hydroxytryptophan and 5-hydroxytryptamine with dopamine metabolism in the rat striatum. (springer.com)
  • Both MDMA and MDA, and their respective optical isomers, were assayed as to their affinity at radio-labelled serotonin (5-HT1 and 5-HT2) and dopamine (D2) binding sites. (ecstasy.org)
  • The effect of SB-271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. (meta.org)
  • We used quantitative autoradiography to measure the contribution of the 5-hydroxytryptamine (5-HT, serotonin) innervation of rat telencephalon to the synthesis of dopamine (DA) from exogenous L-DOPA. (semanticscholar.org)
  • A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. (mcmaster.ca)
  • 5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. (wikipedia.org)
  • We determined the dose-related serotonin and norepinephrine-depleting effects of the selective neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), in C57BL/6 mice of 2 different ages. (elsevier.com)
  • wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to denervate serotonergic afferent input to the dorsal hippocampus. (cdc.gov)
  • Direct injection of 5,7-dihydroxytryptamine (a selective serotonergic neurotoxin) into the dorsal raphe produced a reduction in 3H-paroxetine binding levels throughout the brain, thereby confirming the selectivity of 3H-paroxetine for the serotonin nerve terminal transporter site. (ucl.ac.uk)
  • After initial screening for an evenly matched baseline alcohol preference, selective central serotonergic lesioning was induced by intracisternal injection of the serotonergic neurotoxin 5,7- dihydroxytryptamine (5,7-DHT). (elsevier.com)
  • Neurotoxin treatments had no effect on 5-HT clearance in the corpus callosum. (uthscsa.edu)
  • 5,7-DHT injection caused a significant reduction of the serotonin level in all regions of the brain. (elsevier.com)
  • The level of each neuropeptide except dynorphin significantly increased in specific regions of the brain after 5,7-DHT treatment without any decrease in their levels in any region. (elsevier.com)
  • MDMA, which produced a substantial and selective reduction of brain 5-HT, had no effect on choice accuracy. (aspetjournals.org)
  • Methylenedioxymethamphetamine (MDMA) and 5,7-dihydroxytryptamine (5,7-DHT) were used as positive controls because both compounds deplete brain serotonin. (cdc.gov)
  • Serotonin neurotoxins: Effects of drugs on the destruction of brain serotoninergic, noradrenergic and dopaminergic axons in adult rat by intraventricularly, intracisternally or intracerebrally administered 5,7-dihydroxytryptamine and related compounds. (springer.com)
  • 5-HT) is a neuro-transmitter widely distributed in the brain. (springer.com)
  • Metabolism of 5-hydroxytryptophan- 14 C after intracisternal injection with and without the influence of drugs in the rat brain. (springer.com)
  • 5 Jülich-Aachen Research Alliance-Translational Brain Medicine. (sciencemag.org)
  • MDMA and another drug, 5,7-dihydroxytryptamine (5,7-DHT), were used as controls because both drugs push serotonin out of the brain cells. (antidepressantsfacts.com)
  • To test the hypothesis that serotonin (5-HT) has a critical role in the development of opiate withdrawal, we have employed a near-total brain 5-HT system lesion technique (90% depletion) using 5,7-dihydroxytryptamine combined with induction of opiate dependence by implantation of morphine pellets or by repeated injections of increasing doses of morphine. (scripps.edu)
  • [ 4 ] [ 5 ] The O - methylated analogue of αMS, 5-MeO-αMT , also readily enters the brain and may be used for this purpose as well. (worldheritage.org)
  • Background Serotonin (5-HT) is a potent regulator of adult neurogenesis in the crustacean brain, as in the vertebrate mind. (livingseas.org)
  • These data show for the first time in the whole animal that 5-HT clearance in brain is regionally distinct with regard to rate and affinity. (uthscsa.edu)
  • Patients with autism spectrum disorder (ASD) may have low brain serotonin concentrations as reflected by the serotonin end-metabolite 5-hydroxyindolacetic acid (5HIAA) in cerebrospinal fluid (CSF). (biomedcentral.com)
  • Norepinephrine and serotonin in the hippocampus were assayed 1 week after the intracerebroventricular (i.c.v.) administration of 5,7-DHT. (elsevier.com)
  • Identification of the 5‐hydroxytryptamine2C receptor as a 60‐kDa N‐glycosylated protein in choroid plexus and hippocampus. (deepdyve.com)
  • Earlier studies in this laboratory have shown that partial serotonergic (5-HT) deafferentation from the hippocampus induced a homotypic sprouting. (nyu.edu)
  • In the second, the transplantation was performed 2 weeks after the specific removal of 5‐HT afferents to the hippocampus with 5,7‐dihy‐droxytryptamine (5,7‐DHT). (nyu.edu)
  • It also resulted in increased GR/MR ratio, BDNF and 5-HT1A receptor levels in the hippocampus. (biomedcentral.com)
  • 5,7-DHT produced equivalent, dose-related depletion of hippocampal norepinephrine in both age groups. (elsevier.com)
  • 5,7-dihydroxytryptamine/desmethylimipramine which produced a near-total reduction of 5-HT and a modest reduction of norepinephrine, impaired choice accuracy in all three variations of the task. (aspetjournals.org)
  • These data suggest that selective damage to the 5-HT system, like that produced by MDMA, is not sufficient to impair memory, but that combined damage to the 5-HT and norepinephrine systems can disrupt performance in tasks that require recent memory. (aspetjournals.org)
  • LSD, lisuride, 2-methyl-5-HT, tryptamine and 5-benzyloxytryptamine behaved as partial agonists relative to 5-HT. (meta.org)
  • The lesion-induced reduction of the 5-HT1B autoreceptor-mediated inhibition of evoked 5-HT release may be an adaptation enhancing serotonergic transmission in the (few) remaining terminals. (univoak.eu)
  • 5,7-Dihydroxytryptamine lesion of serotonergic cells and processes produced no changes in [ 125 I]7-OH-PIPAT binding. (aspetjournals.org)
  • and on the contrary to lesion the presynaptic 5-HT with 5-HT depletion method by 5,7-dihydroxytryptoamine, 5,7-DHT. (psychiatryinvestigation.org)
  • We also found that the noradrenergic-depleting effects of 5,7-DHT were blocked by the non-selective MAO inhibitor pargyline (50mg/kg, i.p.), whilethe selective MAO B inhibitor deprenyl (10 mg/kg, i.p.) failed to prevent this depletion. (elsevier.com)
  • 5-Fluoro-αMT has been found to act as a potent and selective MAO-A inhibitor , [ 1 ] [ 2 ] and also as a 5HT 2A receptor agonist. (gutenberg.org)
  • The present study investigated the neurochemical effects of the selective 5-HT(6) receptor antagonist SB-271046 in the rat medial prefrontal cortex (mPFC). (meta.org)
  • Intrathecal pretreatment with 5,7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine and NE levels, respectively, but had no effect on adenosine release from dorsal spinal cord synaptosomes evoked by K+ or morphine. (unboundmedicine.com)
  • Exposure of dorsal, but not ventral, spinal cord synaptosomes to capsaicin produced a dose- and Ca++-dependent release of adenosine, which was reduced by capsaicin pretreatment (neonatal and adult) and inhibition of ecto-5'-nucleotidase. (unboundmedicine.com)
  • This release of adenosine and cyclic AMP was reduced after i.t. pretreatment with 5,7-dihydroxytryptamine (100 micrograms) but not 6-hydroxydopamine (100 micrograms). (islandscholar.ca)
  • Pretreatment with 5,7-dihydroxytryptamine that resulted in a 90% reduction in 5-HTT density, modestly reduced V max in dentate gyrus but not in CA3. (uthscsa.edu)
  • Long-term serotonin changes are blocked by 5-HT re-uptake blockers, and the interactions between MDMA and caffeine have been reported. (ecstasy.org)
  • 5-APB , 5-MAPB , 6-APB and other substituted benzofurans , MDAI , MDMA ). (wikipedia.org)
  • The uptake of 5-hydroxytryptamine- 3 H from cerebral ventricles: autoradiographic localization. (springer.com)
  • These data indicate that hippocampal uptake of 5-HT may be mediated by two processes, one with high affinity but low capacity (i.e. the 5-HTT) and the other with low affinity but a high capacity (i.e. the NET). (uthscsa.edu)
  • Regulation of synapse density by 5-HT-2A receptor agonist and antagonist in the spinal cord of embryo' Neuroscience Letters. (nii.ac.jp)
  • the P. clarkii 5-HT2-specific antagonist methiothepin mesylate salt (MMS) suppresses neurogenesis in this region. (livingseas.org)
  • By contrast, the NET antagonist, desipramine, significantly inhibited 5-HT clearance when extracellular concentrations of 5-HT were greater than the K T value. (uthscsa.edu)
  • Pindobind (0.5 μ g i.t.), a 5-HT 1A antagonist, notably attenuated EAA at different frequencies. (hindawi.com)
  • The 5-HTP-induced changes include elevation of serum prolactin decrease in operant responding, and the magnitude of the "serotonin behavioral syndrome" observed after 5-HTP administration. (elsevier.com)
  • Tryptamine derivatives with substitutions at the 4 and 7 positions on the phenyl ring, the indole nitrogen, and the β position show up to 40-fold potency differences for inhibiting [ 3 H]5-HT transport in cells transfected with either human or Drosophila melanogaster SERT cDNAs. (aspetjournals.org)
  • α-Methylserotonin ( αMS ), also known as α-methyl-5-hydroxytryptamine ( α-methyl-5-HT ) or 5-hydroxy-α-methyltryptamine ( 5-HO-αMT ), is a tryptamine derivative closely related to the neurotransmitter serotonin (5-HT). (worldheritage.org)
  • 5-Fluoro-α-methyltryptamine ( 5-Fluoro-αMT ) is a tryptamine derivative. (gutenberg.org)
  • 5-methoxy-diisopropyltryptamine ( 5-MeO-DiPT ), often termed Foxy Methoxy or just Foxy , is a tryptamine psychedelic used as a recreational drug. (worldheritage.org)
  • A variety of tryptamine derivatives were tested and showed a significantly higher affinity when the 5-HT6 receptor was labelled with [3H]-5-HT, whereas ergoline compounds and several antagonists had higher affinities when [3H]-LSD was used as radioligand. (meta.org)
  • Subsequently we examined the ability of LSD, 5-HT and a number of tryptamine derivatives to stimulate cAMP accumulation in order to determine their agonist potency and efficacy. (meta.org)
  • Firstly, chronic depletion of serotonin with the pharmacological agent 5,7-dihydroxytryptamine attenuates neurogenesis [3,14]. (livingseas.org)
  • The prenatal saline injection stress increased the corticosterone secretion to a significantly greater extent during conditioned fear stress in offspring at 7 and 28 weeks of age in comparison with controls. (nii.ac.jp)
  • all previously identified cell types exhibiting serotonin-like immunoreactivity (sli) were labeled by intravitreal injection of 5,7-dihydroxytryptamine (5,7-dht). (liverpool.ac.uk)
  • 5,7-Dihydroxytryptamine injection increased binding by 10 to 40% in layers Ib, II, III and IV. (muscimol.xyz)
  • Intravenous injection of 5 mg/kg MBT venom produced immediate decrease in mean arterial pressure, heart rate and respiratory frequency followed by an increase and subsequent progressive decrease. (bvsalud.org)
  • The serotonin concentration in brains of 5,7-DHT-treated animals reached maximum earlier and remained elevated longer than that of controls following administration of 5-HTP. (elsevier.com)
  • Additionally, a significant increase in glial fibrillary acidic protein concentration was found by enzyme-linked immunosorbent assay in the 18-month 5,7-dihydroxytryptamine group compared to the 18-month vehicle and three-month 5,7-dihydroxytryptamine groups. (cdc.gov)
  • 1988). However, although these measurements might provide information on the steady state concentration of 5-HT, they cannot give any information about the 5-HT synthesis rate. (springer.com)
  • On the other hand, the 5-hydroxytryptamine concentration in the hypothalamus from prenatally stressed offspring in adulthood was observed to be higher than controls, in contrast of unaltered serotonin metabolite, 5-hydroxyindoleacetic acid. (nii.ac.jp)
  • Human/ D. melanogaster SERT chimera studies implicated the first two SERT transmembrane domains (TMDs) in the potency of the indole nitrogen-substituted compounds N -isopropyltryptamine (NIT), 5-methoxy- N -isopropyltryptamine (5-MNIT), and the 7-substituted compound 7-benzyloxytryptamine (7BT). (aspetjournals.org)
  • significantly more depleted than all known industrially produced organochlorine compounds (delta Cl-37 = -7 to +6 parts per thousand). (diva-portal.org)
  • Compounds studied included 5 phthalates, its substitutes acetyl tributyl citrate (ATBC) and bis(2-ehtylhexyl) adipate, 12 long and short chain alkylphenols, bisphenol A and benzophenone, most of them high volume production chemicals. (bvsalud.org)
  • Substance P (SP) (10 −8 M) can rapidly reduce the affinity and increase the density of 3 H-5-HT binding sites in spinal cord membranes. (springer.com)
  • These data suggest that i.c.v. morphine activates descending serotonergic pathways to release purines from the spinal cord, and that such release is secondary to release of 5-hydroxytryptamine. (islandscholar.ca)
  • The expression of the spinal 5-HT7R is not altered by peripheral inflammation with carrageenan , suggesting that the lack of antinociceptive effect of the 5-HT7R activation is partly attributable to the absence of changes in the expression of the 5-HT7R in the spinal cord . (bvsalud.org)
  • SB-271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5-HT neurotransmission. (meta.org)
  • Despite the critical role of SERT in 5-HT inactivation and psychostimulant response, many aspects of the transporter's recognition of ligands are poorly defined. (aspetjournals.org)
  • The effect of serotonergic pathway lesioning with intrathecal 5,7-dihydroxytryptamine (5,7-DHT) on the expression of the phospho-ERK was measured. (bvsalud.org)
  • History The monoamine neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) can be discovered in the anxious systems of all microorganisms and can be known to impact varied physical, cognitive and behavioral functions [1]. (livingseas.org)
  • MRs have a role in behavioral reactivity during novel situations [ 7 ], whereas GRs are involved in consolidation of learned information. (biomedcentral.com)
  • Methysergide had similar effects when injected into the fourth ventricle, pontomedullary cistern, or lateral ventricle in doses that were 7-10% of the critical i.v. dose, but had no effect when injected into the spinal subarachnoid space. (biomedsearch.com)
  • 7. Fink, G. & Schofield, G.C. (1971) Experimental studies on the innervation of the ovary in cats. (georgefink.com)
  • Berger, U.V., Gu, X.F. and Azmitia, E.C. The Substituted Amphetamines 3,4-Methylenedioxymethamphetamine, Methamphetamine, p-Chloroamphetamine and Fenfluramine Induce 5-Hydroxytryptamine Release via a Common Mechanism Blocked by Fluoxetine and Cocaine. (ecstasy.org)
  • 2-aminomethyl-5-hydroxy-4h-pyran-4-one), a compound which shares some structural features with gamma-aminobutyric acid (gaba) and muscimol, has been examined in a variety of test systems for gabamimetic activity. (liverpool.ac.uk)
  • Therefore, most oxy-cholesterols hydroxy-5-cholestenonic acid. (pdfdrug.com)
  • These results further support the rationale for the use of 5-HT(6) receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases. (meta.org)
  • 5,7-Dihydroxytryptamine (100 μ g i.t.) significantly inhibited EAA at different frequencies on the 7th day after EAc. (hindawi.com)
  • 125 I]7-OH-PIPAT bound in a saturable and reversible manner and exhibited subnanomolar affinity for a single population of GTP-insensitive sites. (aspetjournals.org)
  • Substance P reduces affinity and increases density of 3 H-5-HT binding sites. (springer.com)
  • The "R" isomers of both drugs showed a moderate affinity at the 5-HT2 receptor (labelled with 3H ketanserin), and the "S" isomers were lower. (ecstasy.org)
  • Apparent affinity (K T ) of the serotonin transporter (5-HTT) was similar in DRN and CA3 but greater in dentate gyrus and corpus callosum. (uthscsa.edu)
  • A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-microns segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. (uni-bielefeld.de)
  • They also decreased the inhibitory effects of CP-93,129 on the evoked release of [3H]5-HT. (univoak.eu)
  • The facilitated release of acetylcholine is probably caused by a reduced serotonergic tone on the inhibitory 5-HT1B heteroreceptors of the cholinergic terminals. (univoak.eu)
  • Although the inhibitory role of the 5-hydroxytrypatmine receptor 7(5-HT7R) on nociceptive processing is generally recognized, an excitatory effect associated with a reduced 5-HT7R expression has also been observed in the nerve injury model. (bvsalud.org)
  • Partial depletion of neuronal serotonin (after p-chlorophenylalanine or 5,7-dihydroxytryptamine treatment) had no effect on either phase. (biomedsearch.com)
  • Further, the distribution of 5-HT1 and 5-HT2 mRNAs and protein indicate that these serotonergic results are exerted straight on particular years of neuronal precursors. (livingseas.org)
  • Somewhat unexpectedly, older mice were found to be less susceptible to the serotonin-depleting effects of 5,7-DHT. (elsevier.com)
  • Animal studies on 5-Bromo-DMT showed that it produces effects suggestive of sedative and antidepressant activity and caused significant reduction of locomotor activity in the rodent FST model. (wikipedia.org)
  • The mechanism that produces the hallucinogenic and entheogenic effects of 5-MeO-DiPT is thought to result primarily from 5-HT 2A receptor agonism, although additional mechanisms of action such as MAOI may be involved also. (worldheritage.org)
  • Effects of milnacipran, a 5-HT and noradrenaline reuptake inhibitor, on C-fibre-evoked field potentials in spinal long-term potentiation and neuropathic pain. (semanticscholar.org)