5,7-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.5,6-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.Dihydroxytryptamines: Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.Serotonin Agents: Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.Iproniazid: An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Raphe Nuclei: Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.3,3'-DiaminobenzidineIsoquinolines: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Injections, Intraocular: The administration of substances into the eye with a hypodermic syringe.Intercellular Junctions: Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Neurogenesis: Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.Dentate Gyrus: GRAY MATTER situated above the GYRUS HIPPOCAMPI. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called GRANULE CELLS, whose AXONS pass through the polymorphic layer ending on the DENDRITES of PYRAMIDAL CELLS in the hippocampus.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Neural Stem Cells: Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.Hypothalamus, Anterior: The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.Hemicholinium 3: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.Hypothalamus, Posterior: The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial maxillary nucleus, lateral mammillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.Preoptic Area: Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM.Metergoline: A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.Hypothalamus: Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.MaleatesHistory, 20th Century: Time period from 1901 through 2000 of the common era.GermanySTAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.Buthionine Sulfoximine: A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)Urinary Sphincter, Artificial: An artifical implanted device, usually in the form of an inflatable silicone cuff, inserted in or around the bladder neck in the surgical treatment of urinary incontinence caused by sphincter weakness. Often it is placed around the bulbous urethra in adult males. The artificial urinary sphincter is considered an alternative to urinary diversion.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.alpha7 Nicotinic Acetylcholine Receptor: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.Electrical Synapses: Specialized junctions between NEURONS which connect the cytoplasm of one neuron to another allowing direct passage of an ion current.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Amacrine Cells: INTERNEURONS of the vertebrate RETINA. They integrate, modulate, and interpose a temporal domain in the visual message presented to the RETINAL GANGLION CELLS, with which they synapse in the inner plexiform layer.Biotin: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.Photoreceptor Cells: Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Photoreceptor Cells, Vertebrate: Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.Dark Adaptation: Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.Behavioral Sciences: Disciplines concerned with the study of human and animal behavior.Social Sciences: Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Behavioral Research: Research that involves the application of the behavioral and social sciences to the study of the actions or reactions of persons or animals in response to external or internal stimuli. (from American Heritage Dictionary, 4th ed)Exploratory Behavior: The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.Bombyx: A genus of silkworm MOTHS in the family Bombycidae of the order LEPIDOPTERA. The family contains a single species, Bombyx mori from the Greek for silkworm + mulberry tree (on which it feeds). A native of Asia, it is sometimes reared in this country. It has long been raised for its SILK and after centuries of domestication it probably does not exist in nature. It is used extensively in experimental GENETICS. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p519)Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Behavior, Animal: The observable response an animal makes to any situation.
... (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
5,7-Dihydroxytryptamine MPTP Oxidopamine Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2- ... 5 (7): 1925-1933. PMID 3926960. Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on ...
5,7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake ... Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic ...
44 (5): 329-335. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143. Fuller, R. W.; Baker, J. C. (1974). "Long-lasting ... Gal, E. M.; Cristiansen, P. A.; Yunger, L. M. (1975). "Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in ... Colado, M. I.; Murray, T. K.; Green, A. R. (1993). "5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), ... Curzon, G; Fernando, J. C.; Marsden, C. A. (1978). "5-Hydroxytryptamine: The effects of impaired synthesis on its metabolism ...
List of MeSH codes (D03)
6-dihydroxytryptamine MeSH D03.438.473.914.201.263 --- 5,7-dihydroxytryptamine MeSH D03.438.473.914.237 --- n,n- ... 5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 --- 4-chloro-7-nitrobenzofurazan MeSH D03.383. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin ...
5,7-Dihydroxytryptamine polyclonal antibody - (PAB0054) - Products - Abnova
5,7-dihydroxytryptamine conjugated with carrier protein. (PAB0054) - Products - Abnova ...http://www.abnova.com/products/products_detail.asp?catalog_id=PAB0054
7-methyl-5,6-dihydroxytryptamine Summary Report | CureHunter
6-dihydroxytryptamine: RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the molecular ... 6-dihydroxytryptamine RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the molecular ... 7-methyl-5,6-dihydroxytryptamine. Subscribe to New Research on 7-methyl-5, ...http://www.curehunter.com/public/keywordSummaryC046486-7-methyl-5-6-dihydroxytryptamine.do
4,7-dimethyl-5,6-dihydroxytryptamine Summary Report | CureHunter
6-dihydroxytryptamine: RN & structure given in first source; RN not in Chemline 10/85; suitable probe for elucidating the ... 6-dihydroxytryptamine RN & structure given in first source; RN not in Chemline 10/85; suitable probe for elucidating the ... 4,7-dimethyl-5,6-dihydroxytryptamine. Subscribe to New Research on 4,7-dimethyl-5, ...http://www.curehunter.com/public/keywordSummaryC046484-4-7-dimethyl-5-6-dihydroxytryptamine.do
Experiments in which 5,7-DHT was applied to retinas incubated in vitro gave identical results. To see the whole shape of the ... To study the cells as a population, we used a new method in which the fluorescence of 5,7-DHT is photochemically converted to ... They have 5-8 radially branching primary dendrites which extend horizontally across the inner plexiform layer before descending ... They were labeled to essentially the same brightness and remained so despite variations in the concentration at which 5,7-DHT ...http://www.jneurosci.org/content/6/11/3331
5,7-Dihydroxytryptamine - Wikipedia
5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...https://en.wikipedia.org/wiki/5,7-Dihydroxytryptamine
5,7-Dihydroxytryptamine - The Full Wiki
5-HT2C. Agonists: Phenethylamines: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • ... 5-HT5B*. Agonists: Lysergamides: Ergotamine • LSD. Antagonists: Metitepine/Methiothepin. * Note that the 5-HT5B receptor is not ... 5-HT7. Agonists: Lysergamides: LSD; Tryptamines: 5-CT • 5-MT; Others: 8-OH-DPAT • AS-19 • Bifeprunox • LP-12 • LP-44 • ... 5-HT2A. Agonists: Lysergamides: ALD-52 • Ergonovine • Lisuride • LA-SS-Az • LSD • Lysergic acid 2-butyl amide • Methysergide; ...http://www.thefullwiki.org/5,7-Dihydroxytryptamine
ChemIDplus - 133983-26-3 - DPIHOKBTEPDNAI-UHFFFAOYSA-N - 4,7-Difluoro-5,6-dihydroxytryptamine creatinine - Similar structures...
6-dihydroxytryptamine creatinine - Similar structures search, synonyms, formulas, resource links, and other chemical ... 6-dihydroxytryptamine creatinine. RN: 133983-26-3. InChIKey: DPIHOKBTEPDNAI-UHFFFAOYSA-N. Note. *. Tool for the study of the ... 2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one compd. with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ... 1S/C10H10F2N2O2.C4H7N3O.H2O4S/c11-6-5-4(1-2-13)3-14-8(5)7(12)10(16)9(6)15;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h3,14-16H,1-2,13H2;2H2, ...https://chem.nlm.nih.gov/chemidplus/rn/133983-26-3
NIOSHTIC-2 Publications Search - 20025237 - Immunohistochemical localization and quantification of glial fibrillary acidic...
wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to ... wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to ... Following three weeks pretreatment with 5,7-dihydroxytryptamine (20 microg total dose) or vehicle (0.1% ascorbic saline; 2 ... wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine.. ...https://www.cdc.gov/niosh/nioshtic-2/20025237.html
A CNS serotonergic mechanism in acute central hypovolemia in conscious rabbits?
5,7-Dihydroxytryptamine / pharmacology. Animals. Arginine Vasopressin / blood. Blood Pressure / drug effects. Cardiac Output / ... Partial depletion of neuronal serotonin (after p-chlorophenylalanine or 5,7-dihydroxytryptamine treatment) had no effect on ... or lateral ventricle in doses that were 7-10% of the critical i.v. dose, but had no effect when injected into the spinal ... 7-Dihydroxytryptamine; 361-37-5/Methysergide; 50-67-9/Serotonin; 60634-51-7/LY 53857; 7424-00-2/Fenclonine; EC 18.104.22.168/Renin ...http://www.biomedsearch.com/nih/CNS-serotonergic-mechanism-in-acute/1376801.html
Karimi M[au] - PubMed - NCBI
5.. Synthesis of ion-imprinted polymer-decorated SBA-15 as a selective and efficient system for the removal and extraction of ... 7.. Association of TNF-α -308G,A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer - a Systematic Review ... Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?. Farahani S, Nasirinezhad F, Danyali S, ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Karimi+M%5Bau%5D&dispmax=50
DSP-4 - Wikipedia
5,7-Dihydroxytryptamine MPTP Oxidopamine Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2- ... 5 (7): 1925-1933. PMID 3926960. Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on ...https://en.wikipedia.org/wiki/DSP-4
NOPR: Olfactory bulb serotonin level modulates olfactory recognition in neonate rat
Dihydroxytryptamine;Neonate rat;Neurotransmitters;Olfactory recognition;Serotonin. Issue Date: Nov-2010. ... Significant difference in the olfactory recognition test was observed during PND5-7; control pups successfully recognized and ...http://nopr.niscair.res.in/handle/123456789/10460
Electrophysiological characterization of dopaminergic and non-dopaminergic neurones in organotypic slice cultures of the rat...
Segal M (1986) 5,7-Dihydroxytryptamine modifies excitability of rat dorsal raphe serotonergic neurons in vitro. Neurosci Lett ... Nedergaard S, Flatman JA, Engberg I (1991) Excitation of substantia nigra pars compacta neurones by 5-hydroxy-tryptamine in ... Organotypic slice culture 5,7-Dihydroxytryptamine Dopaminergic neurones Ventral mesencephalon Substantia nigra Rat ... Wuttke W, Hancke JL, Höhn KG, Baumgarten HG (1978) Effect of intraventricular injection of 5,7-dihydroxytryptamine on serum ...https://link.springer.com/article/10.1007/BF00241116
Interactions of Tryptamine Derivatives with Serotonin Transporter Species Variants Implicate Transmembrane Domain I in...
A, evaluation of 7-MT, 7-BT, 4-HT, and 5-MN potency for hSERT. The rank order potency for hSERT is 7-MT , 7-BT , 4-HT , 5-MN (K ... A, 7-BT shifts Y95F to the dSERT-like value. K I values: hSERT, 12.8 ± 0.7 μM; dSERT, 1.82 ± 0.04 μM; Y95F, 2.2 ± 0.2 μM. B, ... 7-MT. 7-methyltryptamine. 7-BT. 7-benzyloxytryptamine. NIT. N-isopropyltryptamine. 5-MNIT. 5-methoxy-N-isopropyltryptamine. ... All compounds except 5-HT displayed a 5-fold or greater difference in K I values between hSERT and dSERT as assessed by ...http://molpharm.aspetjournals.org/content/59/3/514?ijkey=7d04c8838aef892ee3830699916f5ad1f0df2170&keytype2=tf_ipsecsha
Neurotoxicity of 25-OH-cholesterol on NGF-differentiated PC12 cells.
Previous Document: Immediate and long-term effects of 5,7-dihydroxytryptamine on rat striatal serotonergic neurons meas.... ... 2140-46-7/25-hydroxycholesterol; 4431-00-9/Aurintricarboxylic Acid; 50-81-7/Ascorbic Acid; 60-92-4/Cyclic AMP; 7447-40-7/ ...http://www.biomedsearch.com/nih/Neurotoxicity-25-OH-cholesterol-NGF/9482261.html
In Vivo Methods for the Rate of Serotonin Synthesis and Axonal Transport Measurements in the Brain | Springer for Research &...
5 (ed. A. A. Boulton, G. B. Baker and P. H. Yu). Humana Press, Clifton, NJ, pp. 33-78CrossRefGoogle Scholar ... Ng, L. K. Y., Chase, T. N., Colburn, R. W. and Kopin, I. J. (1972). Release of 3H-dopamine by L-5-hydroxytryptophan. Brain Res. ... Serotonin (5-hydroxytryptamine; 5-HT) is a neuro-transmitter widely distributed in the brain. It has been implicated in many ... Aghajanian, G. K., Bloom, F. E., Lovel, R., Sheard, M. and Freedman, D. X. (1966). The uptake of 5-hydroxytryptamine-3H from ...https://rd.springer.com/chapter/10.1007/978-1-349-12272-1_2
Hormonal Receptor Plasticity in the Brain as Shown by In Vitro Quantitative Autoradiography | SpringerLink
Evidence for 5-HT1 binding sites on 5-HT containing neurons in the raphe dorsalis and centralis of the rat brain. Neurochem. ... Characteriezation and radioautography of 3H-LSD by rat brain slices in vitro: the effect of 5-hydroxytryptamine. Eur. J. ... Characteristics of central 5-HT receptors and their adoptive changes following intracerebral 5,7-dihydroxytryptamine ... 7-dihydroxytryptamine and related compounds. In Neurotoxin, Fundamental and Clinical Advances, I.W. Chubb, L.B. Geffen eds, ...https://link.springer.com/chapter/10.1007/978-1-4684-5131-3_34
Frontiers | Neuropeptide Y in Alcohol Addiction and Affective Disorders | Endocrinology
Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J ... 5. Larhammar D. Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept (1996) 62:1-11. doi:10.1016/0167 ... 7. Higuchi H, Yang HY, Sabol SL. Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and ... The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydrobenzothiepino[5,4-d]thiazol-2-yl)amino] ...https://www.frontiersin.org/articles/10.3389/fendo.2017.00178/full
Protocols and Video Articles Authored by Jean-Christophe Cassel
In 5-HT1B KO mice, 5-HT release was enhanced in both structures, while ACh release (in nCi) was reduced. ACh release was ... At the 5-day delay, only rats with GABAergic or combined lesions exhibited a retention deficit. At the 25-day delay, all three ... Increased Expression of 5-HT(1B) Receptors by Herpes Simplex Virus Gene Transfer in Septal Neurons: New in Vitro and in Vivo ... With the 5-HT7 antagonist SB 269970, the 8-OH-DPAT-induced acquisition deficit seemed attenuated, but there was no subsequent ...https://www.jove.com/author/Jean-Christophe_Cassel
Paracetamol: Update on its Analgesic Mechanism of Action | IntechOpen
6-dihydroxytryptamine or total depletion of the central serotonin (5-HT) synthesis by p-chlorophenylalanine. These results were ... Later studies showed that the spinal role of 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptor subtypes of serotonin receptors was ... For example, spinal 5-HT1A is involved in the analgesic action of paracetamol assessed in the formalin test (chemical stimulus ... 5. New strategies to alleviate pain: pharmacological vectorization to target brain TRPV1 receptors. A high-concentration of ...https://www.intechopen.com/books/pain-relief-from-analgesics-to-alternative-therapies/paracetamol-update-on-its-analgesic-mechanism-of-action
- Liu J, Chu YX, Zhang QJ, Wang S, Feng J, Li Q. 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats. (thefullwiki.org)
- CCK-4 (10 −8 M) but not CCK-8 (10 −8 M) can rapidly reduce the affinity and increase the number of the 3 H-spiperone binding sites linked to 5-HT receptors of the dorsal cerebral cortex of rats. (springer.com)
- Taken together the present findings give evidence that neuropeptide receptors and glutamate receptors can in vitro rapidly modulate the characteristics of different types of DA and 5-HT receptors by way of receptor-receptor interactions at the comodulate level or at the local circuit level. (springer.com)
- Despite the critical role of SERT in 5-HT inactivation and psychostimulant response, many aspects of the transporter's recognition of ligands are poorly defined. (aspetjournals.org)
- Within TMD I-II, species-scanning mutagenesis implicated a single residue (Y95 in human SERT, F90 in D. melanogaster SERT) in the recognition of NIT, 5-MNIT, and 7BT. (aspetjournals.org)