Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.
Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.
Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Decarboxylated monoamine derivatives of TRYPTOPHAN.
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
Injections into the cerebral ventricles.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
The observable response an animal makes to any situation.
It is a benzenetriol which is phenethylamine, where the hydrogens on the phenyl ring at positions 2, 4 and 5 are replaced by ... 7 (7): 726-735. doi:10.1038/nn1265. ISSN 1546-1726. Pantic, Igor; Cumic, Jelena; Skodric, Sanja Radojevic; Dugalic, Stefan; ... 5,7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Simola, Nicola; Morelli, Micaela; Carta, Anna R. (2007-09-01 ... 42 (5): 675-685. doi:10.1016/j.freeradbiomed.2006.12.004. ISSN 0891-5849. Farzam, Ali; Chohan, Karan; Strmiskova, Miroslava; ...
5,7-Dihydroxytryptamine MPTP Oxidopamine Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2- ... 5 (7): 1925-1933. doi:10.1523/jneurosci.05-07-01925.1985. PMC 6565098. PMID 3926960. Jaim-Etcheverry G, Mari'a Zieher L (1980 ...
... (THM) is a neurotoxin and a metabolite of MDMA. It comes from the ring-hydroxylation of 3,4- ... 2,4,5-Trihydroxymethamphetamine 5,7-Dihydroxytryptamine Elayan, I.; Gibb, J. W.; Hanson, G. R.; Lim, H. K.; Foltz, R. L.; ... Elayan I, Gibb JW, Hanson GR, Lim HK, Foltz RL, Johnson M (1993). "Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5- ... 5-trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxylase activity". J Pharmacol Exp Ther ...
... , also known as 4-HO-5-MeO-DMT or psilomethoxin, is a novel psychedelic drug. It is the 4- ... This paper reports a 10 step synthesis of 4-HO-5-MeO-DMT from ortho-vanillin. However, Alexander Shulgin has explained that it ... This method was allegedly tested and proven with 5-MeO-DMT by members of the Church of Psilomethoxin in 2021[citation needed], ... XIV (*) - Sur des méthoxy-5 hydroxy-4, méthoxy-5 hydroxy-6 et méthoxy-7 hydroxy-6 tryptamines]". Bull Chim Soc Fr (in French): ...
6-dihydroxytryptamine MeSH D03.438.473.914.201.263 - 5,7-dihydroxytryptamine MeSH D03.438.473.914.237 - N,N-Dimethyltryptamine ... 5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
44 (5): 329-335. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143. Fuller, R. W.; Baker, J. C. (1974). "Long-lasting ... Gal, E. M.; Cristiansen, P. A.; Yunger, L. M. (1975). "Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in ... Colado, M. I.; Murray, T. K.; Green, A. R. (1993). "5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), ... Curzon, G; Fernando, J. C.; Marsden, C. A. (1978). "5-Hydroxytryptamine: The effects of impaired synthesis on its metabolism ...
... (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
6-dihydroxytryptamine in rats". Research Communications in Chemical Pathology and Pharmacology. 8 (1): 29-44. PMID 4847904. " ... 23 (5): 627-634. doi:10.1037/a0015568. PMC 2808210. PMID 19702416. Saults, J. S.; Cowan, N.; Sher, K. J.; Moreno, M. V. (2007 ... 14 (5): 1066-1074. doi:10.1111/j.1467-7687.2011.01060.x. PMC 3177168. PMID 21884322. Cowan, N.; Ricker, T. J.; Clark, K. M.; ... 143 (5): 1806-1836. doi:10.1037/a0036814. PMC 4172497. PMID 24867488. Cowan, N.; Li, D.; Moffitt, A.; Becker, T. M.; Martin, E ...
6-dihydroxytryptamine on tyrosine-hydroxylase activity in central catecholaminergic neurons of the rat". Biochemical ... TMEM155 isoform 5 is the longest mRNA and is 2,429 bp long. The shortest isoform is variant 4 and this variant is 2,035 bp long ... These enhancer sites come on the 5' end of the TMEM155 gene and contain binding sites for transcription factors RCOR1, MILLT1, ... This gene spans from base pairs 121,758,930 and 121,765,427 on chromosome 4. The longest variant ofTMEM155 has 5 exons detailed ...
6-dihydroxytryptamine in rats.. Sarkar, F H; Singh, R H; Udupa, K N. ... Cobalt-induced depletion of dopamine, norepinephrine & 5-hydroxytryptamine concentration in different regions of the rat brain. ... Altered 5-HT metabolism under the influence of 5, ...
1993 Feb; 31(2): 112-5. Abstract: Superfusion of thyrotropin-releasing hormone (TRH) in neonatal rat spinal cord in vitro ... 7-dihydroxytryptamine or 6-hydroxydopamine. Neither serotonin antagonists (spiperone, ketanserin, cyproheptadine or 3-troponyl- ...
6-dihydroxytryptamine in rats.. Sarkar, F H; Singh, R H; Udupa, K N. ... Cobalt-induced depletion of dopamine, norepinephrine & 5-hydroxytryptamine concentration in different regions of the rat brain. ... Altered 5-HT metabolism under the influence of 5, ...
However, identical changes were observed after 5,7-DHT. These results further indicate that FEN and MDMA, like 5,7-DHT, are 5- ... Along with anterograde axonal transport, we measured two 5-HT axonal markers, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). ... These reductions were associated with lasting decrements in 5-HT axonal markers. In general, decreases in axonal transport were ... To further evaluate the serotonin (5-HT) neurotoxic potential of substituted amphetamines, we used tritiated proline to examine ...
5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
6-Dihydroxytryptamine *Molecular FormulaC10H12N2O2 ... indol-5,6-diol [German] [ACD/IUPAC Name] 3-(2-Aminoethyl)-1H. - ... 2-(5,6-Dihydroxy-1H. -indol-3-yl)-ethyl-. ammonium(5,6-DHT) ... indole-5,6-diol [ACD/IUPAC Name] 3-(2-Aminoéthyl)-1H. -indole-5 ...
6-Dihydroxytryptamine and 5,7-Dihydroxytryptamine on the ... Ann.N.Y.Acad.Sci.. 1978. ... 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergi... Brain Res. 1988. Ricaurte GA, Forno LS, Wi.... (+/-)3 ... Effects of MDMA on 5-HT uptake sites using PET and [11C]-McN5652 in hu... Conference of the Ge.... 2000. ... Selective 5-hydroxytryptamine2 receptor antagonists protect against th... J Pharmacol Exp Ther. 1990. ...
However, identical changes were observed after 5,7-DHT. These results further indicate that FEN and MDMA, like 5,7-DHT, are 5- ... Along with anterograde axonal transport, we measured two 5-HT axonal markers, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). ... These reductions were associated with lasting decrements in 5-HT axonal markers. In general, decreases in axonal transport were ... To further evaluate the serotonin (5-HT) neurotoxic potential of substituted amphetamines, we used tritiated proline to examine ...
6-Dihydroxytryptamine and 5,7-Dihydroxytryptamine on the ... Ann.N.Y.Acad.Sci.. 1978. ... 5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-m... J Pharmacol Exp Ther. 1991. ... 5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine Pharmacol Biochem Be.... 1991. ... 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MD... Br J Pharmacol. 1993. ...
However, identical changes were observed after 5,7-DHT. These results further indicate that FEN and MDMA, like 5,7-DHT, are 5- ... Along with anterograde axonal transport, we measured two 5-HT axonal markers, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). ... These reductions were associated with lasting decrements in 5-HT axonal markers. In general, decreases in axonal transport were ... To further evaluate the serotonin (5-HT) neurotoxic potential of substituted amphetamines, we used tritiated proline to examine ...
At three days of age rats were selectively depleted of brain serotonin (5-HT) (desipramine, i.p.. 5,7-dihydroxy tryptamine, i.c ... Acquisition of both drug DS-tasks was similar for control and 5-HT-depleted rats. No significant difference between control and ... Similarly, no differences between control and 5-HT depleted were observed when the DS was antagonized (LSD: BC105; d-A: ... trifluoperazine). These data suggest that presynaptic 5-HT-processes do not play a major role l in the DS produced by either ...
5-HT and the 5-HT1A receptor in particular also play a seminal role in hippocampal responses to stress. 5-HT1A receptors are ... Patel TD, Zhou FC (2005). Ontogeny of 5-ht1a receptor expression in the developing hippocampus. Brain Res Dev Brain Res 157: 42 ... Jha S, Rajendran R, Fernandes KA, Vaidya VA (2008). 5-Ht2a/2c receptor blockade regulates progenitor cell proliferation in the ... Hancock A, Priester C, Kidder E, Keith JR (2009). Does 5-bromo-2′-deoxyuridine (brdu) disrupt cell proliferation and neuronal ...
5,7-Dihydroxytryptamine hydrobromide. Purity:. ≥95% (HPLC). CAS-Number:. 31363-74-3 (free b. SKU:. H0026 ... 7)50-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36?,37?,38-/m1/s1 ... 7)50-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36?,37?,38-/m1/s1 ...
Cohen, L. & Chapman, H., Sep 1984, In: Labor History. 25, 4, p. 558-564 7 p.. Research output: Contribution to journal › ... Broder, H. & Hinton, V. A., 1984, In: Communication Outlook. 5, 3, p. 10-12. Research output: Contribution to journal › Article ... Brams, S. & Fishburn, P. C., 1984, In: The Sciences. p. 4-5. Research output: Contribution to journal › Comment/debate › peer- ... Leung, K. M., May 1984, In: Solid State Communications. 50, 5, p. 449-452 4 p.. Research output: Contribution to journal › ...
1993 Feb; 31(2): 112-5. Abstract: Superfusion of thyrotropin-releasing hormone (TRH) in neonatal rat spinal cord in vitro ... 7-dihydroxytryptamine or 6-hydroxydopamine. Neither serotonin antagonists (spiperone, ketanserin, cyproheptadine or 3-troponyl- ...
After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a ... After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a ... After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a ... After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a ...
в журнале Neuroscience and Behavioral Physiology, издательство Kluwer Academic/Plenum Publishers (United States), том 43, № 7, ... в журнале Neuroscience and Behavioral Physiology, издательство Kluwer Academic/Plenum Publishers (United States), том 35, № 5, ... в журнале Neuroscience and Behavioral Physiology, издательство Kluwer Academic/Plenum Publishers (United States), том 35, № 5, ... в журнале Neuroscience and Behavioral Physiology, издательство Kluwer Academic/Plenum Publishers (United States), том 25, № 5, ...
Multiple types of 5-HT and DA receptors may be involved. To date, the 5-HT1A, 5-HT2A and D2 receptors appear to be the most ... The 5-HT2A and 5-HT2A / D2 but not the D2 occupancies we4re significantly different between the two groups. Farde et al. (23) ... 3H]LSD binds to at least six distinct 5-HT receptors with high affinity (5-HT2C, 5-HT1E, 5-HT2A, 5-HT6, and 5-HT7; refs. 9, 128 ... Sertindole, another 5-HT2A / D2 drug, has recently been reported to occupy 80-90% of both 5-HT2A and D2 receptors (93). These ...
6-dihydroxytryptamine in the CNS of the snail Helix pomatia L.. ≫ ... 5-FU (1 time). CT (1 time). ≫. 2006 Use of a combination of computed tomography and endoscopy to assess the response to 5- ... 5,6-DHT (1 time). CNS (1 time). ≫. 1992 Ultrastructural, biochemical and electrophysiological changes induced by 5, ...
6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration. J Pharmacol Exp Ther. 1982;220(2):311-21. ... 7) or phenylephrine (Phe: 50 nmol, n = 8) in Adra1aflox/flox mice or Vgat-Cre;Adra1aflox/flox mice, *P , 0.05, **P , 0.01, ##P ... Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5, ... 5], and (4) a failure of NA to facilitate inhibitory synaptic inputs to SG neurons in mice lacking α1A-ARs. Furthermore, the ...
Because 5-HT has been implicated in learning and memory, the present study was undertaken to examine whether MDMA, by damaging ... 5,7-dihydroxytryptamine/desmethylimipramine which produced a near-total reduction of 5-HT and a modest reduction of ... These data suggest that selective damage to the 5-HT system, like that produced by MDMA, is not sufficient to impair memory, ... The latter treatment group was included to assess the effects of larger 5-HT neuronal lesions than are possible with MDMA. Four ...
WB4101 Following Fimbrial Transection And 5,7-Dihydroxytryptamine-Induced Lesions Life Sciences 1985 37(20):1913-1922 ... Fimbrial transection or 5,7-diLydroxytryptamine injections produced 32% and 44 0ncreases in the Bmax of [3H]NVB4101 binding in ... "Up-Regulatlon of Serotonergic Binding Sites Labeled By [3H]WB4101 Following Fimbrial Transection And 5,7-Dihydroxytryptamine- ... Lesions of the serotonergic afferents to the hippocampus, by fimbrial transection or by 5,7-dibydroxytryptamine treatment, ...
The increase in blood pressure seen following 5,7-DHT treatment was associated with increases in adrenaline and vasopressin ... The increase in blood pressure seen following 5,7-DHT treatment was associated with increases in adrenaline and vasopressin ... keywords = "5,7-Dihydroxytryptamine (5,7-DHT), 6-Hydroxydopamine (6-OHDA), Blood pressure, Noradrenergic neuron, Sympathetic ... The increase in blood pressure seen following 5,7-DHT treatment was associated with increases in adrenaline and vasopressin ...
abstract::5,7-Dihydroxytryptamine (5,7-DHT) is a selective serotonergic neurotoxin by virtue of its selective uptake into 5- ... Li (3 mEq/kg) administered to rats once (1 d) or daily for 7 days (7 d), 24 h before Pilo (15 mg/kg), exacerbated cholinergic ... Alternative splicing regulation of APP exon 7 by RBFox proteins. abstract::RBFox proteins are well-known alternative splicing ... The mechanism by which 5,7-DHT induces neurodegenerative effects remains enigmatic. The mechanism of autoxidation of 5,7-DHT, ...
Basal levels of 5-HT in the dialysates were close to the detection limits of our assay using HPLC with electrochemical ... Injection of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (0.5 and 2.5 micrograms) into the dorsal raphe nucleus ... This stable output of 5-HT was reduced by 57% in rats treated 14 days previously with intracerebroventricular injections of the ... Hippocampal dialysate levels of 5-HT sharply declined over the first hour after dialysis probe implantation, but then became ...
Some of these are tyrosine, 3,4-dihydroxyphenylalanine (DOPA), 3,4-dihydroxytryptamine (dopamine), and norepinephrine. The ... The 5-methoxy derivatives of gramine and serotonin are first choices for future CsAs when considering the new U. S. amendment ... Pemoline (2-amino-5-phenyl-2-oxazolin-4-one) (Traube and Ascher 1913; Howell et al. 192) is presently a controlled substance in ... Hence, allowing only a methoxy substituent at the aryl C-5 position, and a substitution at the carbon alpha to the nitrogen ( ...

No data available that match "5 7 dihydroxytryptamine"


  • 5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. (wikipedia.org)
  • At three days of age rats were selectively depleted of brain serotonin (5-HT) (desipramine, i.p.. 5,7-dihydroxy tryptamine, i.c. (erowid.org)
  • Other molecular conduits, including serotonin (5-HT) and NMDA receptors, have also been implicated in stress-induced hippocampal damage. (nature.com)
  • In order to elucidate the regeneration properties of serotonergic fibers in the hippocampus of methylazoxymethanol acetate (MAM)-induced micrencephalic rats (MAM rats), we examined serotonergic regeneration in the hippocampus following neonatal intracisternal 5,7-dihydroxytryptamine (5,7-DHT) injection. (elsevier.com)
  • After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a small number of serotonergic fibers in the stratum lacunosum-moleculare (SLM) of the hippocampus and in the hilus adjacent to the granular cell layer of the dentate gyrus (DG) had not. (elsevier.com)
  • Prior treatment with FEN or MDMA led to marked reductions in anterograde transport of labeled material to various forebrain regions known to receive 5-HT innervation. (erowid.org)
  • These results further indicate that FEN and MDMA, like 5,7-DHT, are 5-HT neurotoxins. (erowid.org)
  • Biochemical studies of the density of specific types of 5-HT receptors in brain generally produced intriguing findings that supported the hypothesis of some type of serotonergic dysfunction in schizophrenia. (acnp.org)
  • Acquisition of both drug DS-tasks was similar for control and 5-HT-depleted rats. (erowid.org)
  • No significant difference between control and 5-HT-depleted rats was observed with respect to the dose-dependency of either DS. (erowid.org)
  • Selective 5-hydroxytryptamine2 receptor antagonists protect against th. (erowid.org)
  • Furthermore, antipsychotics such as clozapine, risperidone, olanzapine, sertindole, and ziprasidone are antagonistss at multiple 5-HT receptors and have some advantages over selective DA receptor antagonistss. (acnp.org)
  • The first hypotheses concerning the involvement of 5-HT in schizophrenia was advanced by Wooley and Shaw ( 131 ) and Gaddum ( 25 ) based on the attribution of the psychotomimetic effects of lysergic acid diethylamide (LSD, which is structurally related to 5-HT),and its antagonists at brain 5-HT receptors. (acnp.org)
  • 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergi. (erowid.org)
  • Along with anterograde axonal transport, we measured two 5-HT axonal markers, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). (erowid.org)
  • As will be discussed, 5-HT antagonistss such as methysergide, cyproheptadine, ritanserin, and MDL 100907 are not psychotomimetic and may possibly have beneficial effects on specific aspects of psychosis. (acnp.org)
  • Reorganization of ascending 5-HT axon projections in animals previousl. (erowid.org)
  • TRH-induced potentiation of MSR was not altered in spinal cords, obtained from the animals pretreated with 5,7-dihydroxytryptamine or 6-hydroxydopamine. (who.int)
  • Consistent with previous studies [ 7 ], a transient increase in the latency to produce nociceptive behavioral responses in the hot-plate test was observed in control mice ( Adra1a flox/flox mice) after exposure to acute restraint stress (Fig. 1 a), a well-known model of SIA [ 1 ]. (biomedcentral.com)
  • These data suggest that presynaptic 5-HT-processes do not play a major role l in the DS produced by either LSD or d-amphetamine. (erowid.org)
  • The decline of interest in the 5-HT deficiency hypothesis was followed by a nearly 25-year period during which consideration of the role of 5-HT in schizophrenia was limited. (acnp.org)
  • The latter treatment group was included to assess the effects of larger 5-HT neuronal lesions than are possible with MDMA. (erowid.org)
  • Because Alzheimer's disease involves impairments in acetylcholine, 5-HT and norepinephrine systems, animals with combined lesions may provide a useful model to study the mnemonic dysfunctions characteristic of this disease. (erowid.org)
  • In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. (ox.ac.uk)
  • Fimbrial transection or 5,7-diLydroxytryptamine injections produced 32% and 44 0ncreases in the Bmax of [3H]NVB4101 binding in the presence of a prazosin mask. (erowid.org)
  • This stable output of 5-HT was reduced by 57% in rats treated 14 days previously with intracerebroventricular injections of the 5-HT neurotoxin 5,7-dihydroxytryptamine. (ox.ac.uk)
  • The effect of manipulating the activity of central 5-hydroxytryptamine (5-HT) neurones on extracellular 5-HT in ventral hippocampus of the chloral hydrate-anaesthetized rat was studied using the brain perfusion method, microdialysis. (ox.ac.uk)
  • MDMA, which produced a substantial and selective reduction of brain 5-HT, had no effect on choice accuracy. (erowid.org)
  • These data suggest that selective damage to the 5-HT system, like that produced by MDMA, is not sufficient to impair memory, but that combined damage to the 5-HT and norepinephrine systems can disrupt performance in tasks that require recent memory. (erowid.org)
  • However, addition of the selective 5-HT reuptake inhibitor citalopram (10(-6) M) to the perfusion medium produced readily measurable amounts of dialysate 5-HT. (ox.ac.uk)
  • Rats were treated with saline, MDMA or 5,7-dihydroxytryptamine/desmethylimipramine. (erowid.org)
  • The increase in blood pressure seen following 5,7-DHT treatment was associated with increases in adrenaline and vasopressin levels and renal nerve activity throughout the response. (edu.au)
  • We have examined the acute (0-3 h) effect of intracisternally administered 5,7-dihydroxytryptamine (DHT) and 6-hydroxydopamine (6-OHDA) on blood pressure, heart rate, renal nerve activity, plasma adrenaline, plasma noradrenaline and plasma vasopressin in conscious rabbits. (edu.au)
  • The recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') is toxic to central serotonin (5-HT) neurons, but few long-term functional consequences of MDMA neurotoxicity have been identified. (erowid.org)
  • We conclude from these data that the spontaneous output of endogenous 5-HT into hippocampal dialysates, measured under our experimental conditions, predominantly originates from central 5-HT neurones and changes in accordance with their electrical activity. (ox.ac.uk)
  • Lisuride (Lysenyl, Spofa), d-LSD, piribedil, ergometrine, ergocornine and apomorphine induced contralateral turning behavior in rats injected with 5,6-DHT in one MFB, blocked by neuroleptics while methylphenidate and methamphetamine induced ipsilateral turning. (erowid.org)
  • Lu 10-171 prevented a major uptake of 5,7-DHT into 5-HT neurons, but did not alter the neurotoxic effect on dopamine (DA) and NA neurons. (erowid.org)
  • Harmaline reduced the neurotoxicity of 5,7-DHT for CA neurons. (erowid.org)
  • The recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') is toxic to central serotonin (5-HT) neurons, but few long-term functional consequences of MDMA neurotoxicity have been identified. (erowid.org)
  • Because 5-HT has been implicated in learning and memory, the present study was undertaken to examine whether MDMA, by damaging 5-HT neurons, altered mnemonic function on a long-term basis. (erowid.org)
  • In rats treated with parachlorophenylalanine (which inhibits serotonin synthesis) or 5,7-dihydroxytryptamine (which damages serotonergic neurons), BrdU-labeled cells and cells expressing a newborn neuronal marker were depleted from the hippocampus and SVZ. (medscape.com)
  • Particularly important, but controversial, are the contributions of serotonin (5-HT) neurons to respiratory and thermoregulatory control. (jneurosci.org)
  • To better define the roles of 5-HT neurons in breathing and thermoregulation, we took advantage of a unique conditional knock-out mouse in which Lmx1b is genetically deleted in Pet1 -expressing cells ( Lmx1b f/f/p ), resulting in near-complete absence of central 5-HT neurons. (jneurosci.org)
  • These data identify a previously unrecognized role of 5-HT neurons in the CO 2 chemoreflex, whereby they enhance the response of the rest of the respiratory network to CO 2 . (jneurosci.org)
  • Neurons that produce serotonin (5-HT) are restricted to a small number of nuclei in the brainstem. (jneurosci.org)
  • There is also evidence that respiratory output, and some respiratory neurons, can be inhibited in vivo by 5-HT under some conditions ( Lalley, 1986 ). (jneurosci.org)
  • The specific role of 5-HT neurons in respiratory control is also unclear. (jneurosci.org)
  • and this causes an increase in 5-HT release in vivo ( Kanamaru and Homma, 2007 ), indicating that 5-HT neurons are modulated by the acid/base status of the brain. (jneurosci.org)
  • The contribution of 5-HT neurons in the regulation of body temperature, particularly under conditions of decreased ambient temperature, has also not been clearly defined. (jneurosci.org)
  • Serotonin (5-HT) projections from the ascending raphe nuclei reach the dorsal hippocampus via the cingulum bundle (CB) and fimbria-fornix (FF). (nyu.edu)
  • We have previously shown using anatomical methods that partial denervation of the rat hippocampus by removal of serotonergic (5-HT) fibers in the cingulum bundle induces sprouting of intact 5-HT fibers reacting the hippocampus in the fornix-fimbria. (nyu.edu)
  • Unilateral stereotaxic injections of 5 μg 5,7-dihydroxytryptamine were made into the cingulum bundle of adult rats in order to produce partial and selective deafferentation of the hippocampus. (nyu.edu)
  • These results indicate that 5-HT fibers remaining in the hippocampus following partial denervation are able to compensate biochemically for those removed by cingulum bundle lesions. (nyu.edu)
  • In some studies, injection of 5,7-DHT was preceded for various periods of time by an i.p. injection of desmethylimipramine (DMI), maprotiline, Lu 10-17t, or harmaline. (erowid.org)
  • Injection of both 5,6-DHT and 5,7-DHT (the latter under protection of specific noradrenaline (NA) uptake blockers) icv induced a marked decrease of cerebral 5-HT levels, without significantly changing catecholamine (CA) levels. (erowid.org)
  • After icv or local injection in the MFB, 5,7-DHT reduced not only 5-hydroxyindoleacetic acid (5-H[AA) but also homovanillic acid (HVA) levels. (erowid.org)
  • Enhancement of mounting activity, similar to that seen after systemic injection of p-chlorophenylalanine (p-CPA), was induced by icv 5,6-DHT and 5,7-DHT in intact adult male and female rats and in castrated, ovariectomized, or prepubertal rats. (erowid.org)
  • Injection of 5-HT or haloperidol suppressed enhanced sexual activity. (erowid.org)
  • Following injection, enzyme activity in the hippocampus declined gradually and bilaterally, reaching minimal levels by 7 days post-lesion. (nyu.edu)
  • Specific destruction of central serotonin nerve terminals by intraventricular injection of 5,7 dihydroxytryptamine (5,7 DHT, 50 μg) in adult male rats pretreated with a catecholamine uptake blocking agent resulted in marked supersensitivity to serotonin precursors and agonists. (princeton.edu)
  • Microinjection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the CB and FF produces a significant decrease in the density of 5-HT immunoreactive fibers in the hippocampus as early as 3 days postlesion (Zhou, F.C. and Azmitia, E.C. (1983) Brain Res. (nyu.edu)
  • In the present study we used an anti-peptide antibody against the second extracellular loop of the 5-HT 1A receptor and employed immunocytochemistry to examine changes in the expression and distribution of the 5-HT 1A receptor in the hippocampus 14 days following administration of 5,7-DHT into the CB and FF. (nyu.edu)
  • These findings demonstrate that 5-HT denervation in the hippocampus is followed by increased expression of the 5-HT 1A receptor protein. (nyu.edu)
  • These changes in receptor expression 14 days postlesion may represent adaptive changes by postsynaptic cells following reduced 5-HT innervation and may be the molecular basis for 5-HT 1A receptor supersensitivity. (nyu.edu)
  • It also resulted in increased GR/MR ratio, BDNF and 5-HT1A receptor levels in the hippocampus. (biomedcentral.com)
  • The 5 * HT receptor agonist 8-OH-DPAT reduces ethanol intake and maintained behavior in female Sprague-Dawley rats. (rutgers.edu)
  • 5-HT receptor antagonists do not reduce ethanol preference in sardinian alcohol-preferring (sP) rats. (rutgers.edu)
  • 5-HT receptor antagonist, tropisetron, does not influence ethanol-induced conditioned taste aversion and conditioned place aversion. (rutgers.edu)
  • 5-HT receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. (rutgers.edu)
  • 3-Methoxy-4-hydroxypkenylethyleneglycol sulfate (MOPEG-SO4) was moderately increased in rats injected with 5,7-DHT icy. (erowid.org)
  • In midbrain, site of neuronal cell bodies of hippocampal 5-HT projections, enzyme activity gradually increased, reaching a maximum by 28 days after the lesion. (nyu.edu)
  • Since the neurotoxic lesion had no effect on TRH, the 5-HT pathway through the fimbria-fornix is probably anatomically separate from a parallel TRH pathway there. (umn.edu)
  • 5, 7-dihydroxytryptamine lesion does not affect ethanol-induced conditioned taste and place aversion in rats. (rutgers.edu)
  • Effect of central 5-hydroxytryptamine depletion on performance in the "time-left" procedure: Further evidence for a role of the 5-hydroxytryptaminergic pathways in behavioural "switching. (fandom.com)
  • Effect of central 5-hydroxytryptamine depletion on tolerance of delay of reinforcement: Evidence from performance in a discrete-trails "time-left" procedure: Psychopharmacology Vol 141(1) Jan 1999, 22-29. (fandom.com)
  • Effect of central 5-hydroxytryptamine depletion on changeover behaviour in concurrent schedules of reinforcement: Psychopharmacology Vol 144(3) Jun 1999, 264-271. (fandom.com)
  • In contrast to the marked supersensitivity to serotonin precursors and agonists which occurs following 5,7 DHT, chronic administration of a serotonin synthesis inhibitor, p chlorophenylalanine (400 mg/kg every 3 days for a total of 24 days), did not produce supersensitivity to L 5 hydroxytryptophan or 5 methoxy N,N dimethyltryptamine. (princeton.edu)
  • The creatinine sulfate saps of 5,7-DHT (50 mcg of base) and 5,7-DHT (75 mcg of base, Regis) were injected into the right lateral cerebral ventricle of rats. (erowid.org)
  • In this study we further specify the anatomical relationship of TRH with 5-HT by use of surgical and neurotoxic lesioning with reference to limbic forebrain regions wherein TRH is greatly increased following seizures. (umn.edu)
  • 5,7-DHT facilitated lordosis: Effects of 5-HT agonists: Neuroreport: An International Journal for the Rapid Communication of Research in Neuroscience Vol 3(6) Jun 1992, 542-544. (fandom.com)
  • Thus, the rate-limiting enzyme in 5-HT synthesis, tryptophan hydroxylase (TPOH), was studied to determine whether new sprouts possess the ability to synthesize 5-HT. (nyu.edu)
  • A lesser degree of supersensitivity was seen in response to L tryptophan (following monoamine oxidase inhibition) and the direct acting serotonin agonist, 5 methoxy N,N dimethyltryptamine, for which the ED50 was approximately 50% of the control value in both cases. (princeton.edu)
  • Episodic GH secretion reappeared 36 h after the last administration of reserpine, at which time the behavioral inhibition and blepharospasm induced by the drug was less pronounced than after 24 h, but brain levels of CAs and 5-HT were still markedly reduced. (nih.gov)
  • 12, 4, and 2 h before experiments) inhibited episodic GH secretion and caused marked inhibition of motor activity and brain levels of CAs but not 5-HT. (nih.gov)
  • Brain 5-HT levels were reduced. (erowid.org)
  • Selective destruction of midbrain raphe nuclei by 5,7-DHT: Is brain 5-HT involved in alcohol drinking in Sprague-Dawley rats? (fandom.com)
  • MDMA, which produced a substantial and selective reduction of brain 5-HT, had no effect on choice accuracy. (erowid.org)
  • The effects of the various drug treatments on motor activity and brain levels of catecholamines (CAs) and 5-hydroxytryptamine (5-HT) as well as the synthesis of the biogenic amines were also studied. (nih.gov)
  • 72, 48, and 24 h before experiments) had no effect on episodic GH secretion, whereas brain levels of 5-HT and 5-HT synthesis were markedly reduced. (nih.gov)
  • 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced ethoxyresorufin-O-deethylase (EROD) and aldehyde dehydrogenase (ALDH ) activities in the brain and liver: a comparison between the most TCDD-suceptible and the most TCDD-resistant rat strain. (rutgers.edu)
  • Hernadi L. Ultrastructural, Biochemical and Electrophysiological Changes Induced by 5,6-Dihydroxytryptamine in the CNS of the Snail Helix Pomatia L / L. Hernadi, L. Hiripi, A. Vehovszky, G. Kemenes, K. Rozsa // Brain Res. (gramota.net)
  • Lesioning of midbrain raphe nuclei with 5,7-DHT fails to alter ethanol intake in the low alcohol drinking (LAD) rat: Progress in Neuro-Psychopharmacology & Biological Psychiatry Vol 20(3) Apr 1996, 473-482. (fandom.com)
  • In the rat CNS it has previously been shown that TRH is co-localized with 5-HT (and also with substance P) in cell bodies of the posterior raphe that project to the spinal cord. (umn.edu)
  • Stroke in rodents [ 7 ] and humans [ 8 ] stimulates neurogenesis in the anterior subventricular zone (SVZ) and the subgranular zone of the hippocampal dentate gyrus. (medscape.com)
  • In rats lesioned with 5,7-DHT, the enhancement of 5-HT and DA turnover induced by methiothepin was markedly reduced. (erowid.org)
  • When injected stereotaxically into the medial forebrain bundle (MFB), 5,6-DHT markedly and 5,7-DHT slightly decreased cerebral levels of DA, in addition to those of 5-HT. (erowid.org)
  • The greatest degree of supersensitivity was observed in response to L 5 hydroxytryptophan, for which the ED50 for elicitation of the syndrome was 20% of the value for control rats. (princeton.edu)
  • Supersensitivity begins to develop within 24 hours and is relatively complete by 96 hours after 5,7 DHT. (princeton.edu)
  • 5,7-Dihydroxytryptamine-induced mouse killing and behavioral reversal with ventricular administration of serotonin in rats: Behavioral & Neural Biology Vol 30(2) Oct 1980, 178-190. (fandom.com)
  • Comparative Studies of the Effects of Chlorpromazine and 5,6-Dihydroxytryptamine on Locomotion, Defensive Reactions in the Snail Helix Lucorum, and Command Neuron Excitability in Long-Term Sensitization: Neuroscience and Behavioral Physiology Vol 36(7) Sep 2006, 759-766. (fandom.com)
  • Male rats chronically exposed to 5 or 10 mg/kg ATR in the diet for 6 months exhibited persistent hyperactivity and altered behavioral responsivity to amphetamine. (nih.gov)
  • MRs have a role in behavioral reactivity during novel situations [ 7 ], whereas GRs are involved in consolidation of learned information. (biomedcentral.com)
  • 5,7-dihydroxytryptamine/desmethylimipramine which produced a near-total reduction of 5-HT and a modest reduction of norepinephrine, impaired choice accuracy in all three variations of the task. (erowid.org)
  • Although TRH cell bodies are known to be widely distributed throughout the forebrain there is no other known co-localization with 5-HT. (umn.edu)
  • The 5, 7 dihydroxytryptamine treatment nearly eliminated the indoleamines from all the forebrain regions examined while TRH levels were unchanged. (umn.edu)
  • 5,7-Dihydroxytryptamine Injections Increase Glial Fibrillary Acidic Protein in the Hypothalamus of Adult Rats. (epa.gov)
  • However, there are data that suggest that 5-HT can inhibit breathing. (jneurosci.org)
  • 50 mg orally twice a day or 100 mg orally once a day Comments: -If IV beta blockers are contraindicated or inappropriate, oral therapy should continue for at least 7 days post-myocardial infarction (MI). (mymeds3.us)
  • We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense. (jneurosci.org)
  • Neurochemical Research , 17 (5), 469-473. (umn.edu)
  • Electron microscopic studies showed that 5,6-DHT, 5,7-DHT and etaraminol accumulate in rat platelets, with release of 5-HT. (erowid.org)