5,7-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.5,6-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.Dihydroxytryptamines: Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.Serotonin Agents: Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.Iproniazid: An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Raphe Nuclei: Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.p-Chloroamphetamine: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.Methyltyrosines: A group of compounds that are methyl derivatives of the amino acid TYROSINE.Hydroxyindoleacetic AcidLysergic Acid Diethylamide: Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.Tryptophan Hydroxylase: An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Injections, Intraventricular: Injections into the cerebral ventricles.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Behavior, Animal: The observable response an animal makes to any situation.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Electrical Synapses: Specialized junctions between NEURONS which connect the cytoplasm of one neuron to another allowing direct passage of an ion current.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Amacrine Cells: INTERNEURONS of the vertebrate RETINA. They integrate, modulate, and interpose a temporal domain in the visual message presented to the RETINAL GANGLION CELLS, with which they synapse in the inner plexiform layer.Biotin: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.Photoreceptor Cells: Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Hypothalamus, Anterior: The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.Hemicholinium 3: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.Hypothalamus, Posterior: The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial maxillary nucleus, lateral mammillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.Preoptic Area: Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM.MaleatesHistory, 20th Century: Time period from 1901 through 2000 of the common era.GermanySTAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.Buthionine Sulfoximine: A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)Urinary Sphincter, Artificial: An artifical implanted device, usually in the form of an inflatable silicone cuff, inserted in or around the bladder neck in the surgical treatment of urinary incontinence caused by sphincter weakness. Often it is placed around the bulbous urethra in adult males. The artificial urinary sphincter is considered an alternative to urinary diversion.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Research Support as Topic: Financial support of research activities.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Financing, Organized: All organized methods of funding.Research Personnel: Those individuals engaged in research.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Training Support: Financial support for training including both student stipends and loans and training grants to institutions.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Cues: Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.Alcoholic Beverages: Drinkable liquids containing ETHANOL.Alcohol Dehydrogenase: A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
5,7-Dihydroxytryptamine MPTP Oxidopamine Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2- ... 5 (7): 1925-1933. PMID 3926960. Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on ...
5,7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake ... Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic ...
6-dihydroxytryptamine MeSH D03.438.473.914.201.263 --- 5,7-dihydroxytryptamine MeSH D03.438.473.914.237 --- n,n- ... 5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 --- 4-chloro-7-nitrobenzofurazan MeSH D03.383. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin ...
44 (5): 329-335. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143. Fuller, R. W.; Baker, J. C. (1974). "Long-lasting ... Gal, E. M.; Cristiansen, P. A.; Yunger, L. M. (1975). "Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in ... Colado, M. I.; Murray, T. K.; Green, A. R. (1993). "5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), ... Curzon, G; Fernando, J. C.; Marsden, C. A. (1978). "5-Hydroxytryptamine: The effects of impaired synthesis on its metabolism ...
... (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... 9 (5): 879-888. doi:10.3390/md9050879. PMC 3111189. PMID 21673896.. *^ Jin-Feng Hu; John A. Schetz; Michelle Kelly; Jiang-Nan ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges Smenospongia ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-HT6. *Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline ... Rizatriptan acts as an agonist at serotonin 5-HT1B and 5-HT1D receptors. Like the other triptans sumatriptan and ...
Retrieved 5 June 2013.. *^ Guardiola-Lemaître B (December 1997). "Toxicology of melatonin". Journal of Biological Rhythms. 12 ( ... 90 (5): 2755-61. doi:10.1210/jc.2004-2062. PMID 15713707.. *^ Burkhart K, Phelps JR (26 December 2009). "Amber lenses to block ... 1-7. ISBN 9781587631702. PMC 4781368. PMID 15635761.. *^ Filadelfi AM, Castrucci AM (May 1996). "Comparative aspects of the ... Retrieved 5 June 2013.. *^ Mills E, Wu P, Seely D, Guyatt G (November 2005). "Melatonin in the treatment of cancer: a ...
5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British ...
5-HT2C. Agonists: Phenethylamines: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • ... 5-HT5B*. Agonists: Lysergamides: Ergotamine • LSD. Antagonists: Metitepine/Methiothepin. * Note that the 5-HT5B receptor is not ... 5-HT7. Agonists: Lysergamides: LSD; Tryptamines: 5-CT • 5-MT; Others: 8-OH-DPAT • AS-19 • Bifeprunox • LP-12 • LP-44 • ... 5-HT2A. Agonists: Lysergamides: ALD-52 • Ergonovine • Lisuride • LA-SS-Az • LSD • Lysergic acid 2-butyl amide • Methysergide; ...
6-dihydroxytryptamine: RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the molecular ... 6-dihydroxytryptamine RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the molecular ... 7-methyl-5,6-dihydroxytryptamine. Subscribe to New Research on 7-methyl-5, ...
5,7-dihydroxytryptamine conjugated with carrier protein. (PAB0054) - Products - Abnova ...
Kuhn, C. M., Vogel, R. A., Mailman, R. B., Mueller, R. A., Schanberg, S. M., & Breese, G. R. (1981). Effect of 5,7- ... dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology, 73(2), 188-193. ... Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. / Kuhn, Cynthia M.; ... The 5-HTP-induced changes include elevation of serum prolactin decrease in operant responding, and the magnitude of the " ...
6-dihydroxytryptamine creatinine - Similar structures search, synonyms, formulas, resource links, and other chemical ... 6-dihydroxytryptamine creatinine. RN: 133983-26-3. InChIKey: DPIHOKBTEPDNAI-UHFFFAOYSA-N. Note. *. Tool for the study of the ... 1S/C10H10F2N2O2.C4H7N3O.H2O4S/c11-6-5-4(1-2-13)3-14-8(5)7(12)10(16)9(6)15;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h3,14-16H,1-2,13H2;2H2, ... with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ...
5,7-DHT produced equivalent, dose-related depletion of hippocampal norepinephrine in both age groups. Since the effects of 5,7- ... These latter results suggest that it is the A form of MAO that plays an important role in the mechanism of 5,7-DHT-induced ... Finnegan, K. T., DeLanney, L. E., Irwin, I., Ricaurte, G. A., & William Langston, J. (1989). The amine-depleting effects of 5,7 ... 5,7-DHT produced equivalent, dose-related depletion of hippocampal norepinephrine in both age groups. Since the effects of 5,7- ...
wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to ... wt 25,000) following administration of the neurotoxin, 5,7-dihydroxytryptamine, into the fimbria-fornix and cingulum bundle to ... Following three weeks pretreatment with 5,7-dihydroxytryptamine (20 microg total dose) or vehicle (0.1% ascorbic saline; 2 ... wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine.. ...
The lesions reduced the concentration of 5-HT (-90%) and the accumulation (-80%) as well as the evoked release (-90%) of [3H]5- ... 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat ... 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat ... They also decreased the inhibitory effects of CP-93,129 on the evoked release of [3H]5-HT. Most interestingly, they facilitated ...
5,7-Dihydroxytryptamine / pharmacology. Animals. Arginine Vasopressin / blood. Blood Pressure / drug effects. Cardiac Output / ... Partial depletion of neuronal serotonin (after p-chlorophenylalanine or 5,7-dihydroxytryptamine treatment) had no effect on ... or lateral ventricle in doses that were 7-10% of the critical i.v. dose, but had no effect when injected into the spinal ... 7-Dihydroxytryptamine; 361-37-5/Methysergide; 50-67-9/Serotonin; 60634-51-7/LY 53857; 7424-00-2/Fenclonine; EC 126.96.36.199/Renin ...
5.. Synthesis of ion-imprinted polymer-decorated SBA-15 as a selective and efficient system for the removal and extraction of ... 7.. Association of TNF-α -308G,A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer - a Systematic Review ... Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?. Farahani S, Nasirinezhad F, Danyali S, ...
Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. The ... Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. The ... 5-HTP), can induce a behavioral syndrome characterized by rigidity, splayed feet, tremor, head weaving, salivation and forepaw ... 5-HTP), can induce a behavioral syndrome characterized by rigidity, splayed feet, tremor, head weaving, salivation and forepaw ...
The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. Serotonin- ... Retzius cells retain functional membrane properties following ablation by the neurotoxin 5,7-DHT ... leech; Retzius cell; serotonin; 5-hydroxytryptamine; 5,7-dihydroxytryptamine; ablation; glyoxylic acid; fluorescence. ... 7-DHT treatment. However, these brown, mis-shapen, non-fluorescent neurons retain their synaptic inputs, action potentials, ...
7-Dihydroxytryptamine in the Dorsal Raphe Nuclei of Mice, An Immunological Model for Heterotopic Heart and Cardiac Muscle ... Elimination of Serotonergic Neurons by Stereotaxic Injection of 5, ... Elimination of Serotonergic Neurons by Stereotaxic Injection of 5,7-Dihydroxytryptamine in the Dorsal Raphe Nuclei of Mice. ... Yee-Shuan Lee1, Siliang Wu2, Treena Livingston Arinzeh3, Mary Bartlett Bunge1,4,5 ...
5,7-Dihydroxytryptamine MPTP Oxidopamine Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2- ... 5 (7): 1925-1933. PMID 3926960. Jaim-Etcheverry G, Maria Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on ...
Segal M (1986) 5,7-Dihydroxytryptamine modifies excitability of rat dorsal raphe serotonergic neurons in vitro. Neurosci Lett ... Nedergaard S, Flatman JA, Engberg I (1991) Excitation of substantia nigra pars compacta neurones by 5-hydroxy-tryptamine in ... Organotypic slice culture 5,7-Dihydroxytryptamine Dopaminergic neurones Ventral mesencephalon Substantia nigra Rat ... Wuttke W, Hancke JL, Höhn KG, Baumgarten HG (1978) Effect of intraventricular injection of 5,7-dihydroxytryptamine on serum ...
5,7-Dihydroxytryptamine lesions of crayfish serotonin-containing neurons: effect on the lateral giant escape reaction DL ...
Evidence for 5-HT1 binding sites on 5-HT containing neurons in the raphe dorsalis and centralis of the rat brain. Neurochem. ... Characteriezation and radioautography of 3H-LSD by rat brain slices in vitro: the effect of 5-hydroxytryptamine. Eur. J. ... Characteristics of central 5-HT receptors and their adoptive changes following intracerebral 5,7-dihydroxytryptamine ... 7-dihydroxytryptamine and related compounds. In Neurotoxin, Fundamental and Clinical Advances, I.W. Chubb, L.B. Geffen eds, ...
5-HT-depleted rats had significantly higher H-reflex amplitudes compared with control rats (t(74) = 2.31, p = 0.02; Fig. 2A,B ... 5-HT1AR KO mice had smaller motor map areas compared with WT controls. Direct application of the 5-HT1A/7 agonist 8-OH-DPAT to ... The 5-HT1A/7 agonist (R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was used at a concentration of 80 μm (∼0.5 ml ... The 5-HT1A antagonist WAY-100135 maleate salt was used at a concentration of 6 μm (2 μl/injection site, total volume 6 μl) for ...
Dihydroxytryptamine;Neonate rat;Neurotransmitters;Olfactory recognition;Serotonin. Issue Date: Nov-2010. ... Significant difference in the olfactory recognition test was observed during PND5-7; control pups successfully recognized and ...
Previous Document: Immediate and long-term effects of 5,7-dihydroxytryptamine on rat striatal serotonergic neurons meas.... ... 2140-46-7/25-hydroxycholesterol; 4431-00-9/Aurintricarboxylic Acid; 50-81-7/Ascorbic Acid; 60-92-4/Cyclic AMP; 7447-40-7/ ...
A, evaluation of 7-MT, 7-BT, 4-HT, and 5-MN potency for hSERT. The rank order potency for hSERT is 7-MT , 7-BT , 4-HT , 5-MN (K ... A, 7-BT shifts Y95F to the dSERT-like value. K I values: hSERT, 12.8 ± 0.7 μM; dSERT, 1.82 ± 0.04 μM; Y95F, 2.2 ± 0.2 μM. B, ... 7-MT. 7-methyltryptamine. 7-BT. 7-benzyloxytryptamine. NIT. N-isopropyltryptamine. 5-MNIT. 5-methoxy-N-isopropyltryptamine. ... All compounds except 5-HT displayed a 5-fold or greater difference in K I values between hSERT and dSERT as assessed by ...
5 (ed. A. A. Boulton, G. B. Baker and P. H. Yu). Humana Press, Clifton, NJ, pp. 33-78CrossRefGoogle Scholar ... Ng, L. K. Y., Chase, T. N., Colburn, R. W. and Kopin, I. J. (1972). Release of 3H-dopamine by L-5-hydroxytryptophan. Brain Res. ... Serotonin (5-hydroxytryptamine; 5-HT) is a neuro-transmitter widely distributed in the brain. It has been implicated in many ... Aghajanian, G. K., Bloom, F. E., Lovel, R., Sheard, M. and Freedman, D. X. (1966). The uptake of 5-hydroxytryptamine-3H from ...
Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J ... 5. Larhammar D. Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept (1996) 62:1-11. doi:10.1016/0167 ... 7. Higuchi H, Yang HY, Sabol SL. Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and ... The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydrobenzothiepino[5,4-d]thiazol-2-yl)amino] ...
In 5-HT1B KO mice, 5-HT release was enhanced in both structures, while ACh release (in nCi) was reduced. ACh release was ... At the 5-day delay, only rats with GABAergic or combined lesions exhibited a retention deficit. At the 25-day delay, all three ... Increased Expression of 5-HT(1B) Receptors by Herpes Simplex Virus Gene Transfer in Septal Neurons: New in Vitro and in Vivo ... With the 5-HT7 antagonist SB 269970, the 8-OH-DPAT-induced acquisition deficit seemed attenuated, but there was no subsequent ...
Administration of 5,7-dihydroxytryptamineReceptorsRatsDopamineLesionsHippocampusProlactinPretreatmentSelectivePharmacologicalUptakeAntagonistLesionNorepinephrineConcentrationMonoamineLigandsMethysergideInnervationNoradrenalineReceptor subtypesFenfluramineExtracellularEffectsPrefrontal cortexDopaminergicSpinal cordBehavioralCholinergic terminalsCompoundsVitroAffinityTryptamine derivativeEndogenous
- The intracisternal administration of 5,7-dihydroxytryptamine (5,7-DHT) to rats resulted in a potentiated response to 5-hydroxytryptophan (5-HTP) when the animals were tested 30 days later. (elsevier.com)
- wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine. (cdc.gov)
- Using adult rats we determined that pharmacological depletion of serotonin (5-HT) via intracerebroventricular administration of 5,7 dihydroxytryptamine resulted in altered movements of the forelimb in a skilled reaching task as well as higher movement thresholds and smaller maps derived using high-resolution intracortical microstimulation (ICMS). (jneurosci.org)
- Role of serotonin in olfactory recognition was tested by depleting the olfactory bulb serotonin during postnatal day (PND)1- 4 following administration of 5,7-dihydroxytryptamine. (niscair.res.in)
- Enhancement of clonidine-induced analgesia by lesions induced with spinal and intracerebroventricular administration of 5,7-dihydroxytryptamine. (saladgaffe.tk)
- The effect of peripherally administered cyproheptadine or reserpine and the administration of 5,7-dihydroxytryptamine (5,7-DHT) in the nucleus raphe dorsalis on the analgesic activity of salmon calcitonin ( sCT ) injected into the lateral ventricle were investigated in male rats. (manchester.ac.uk)
- Together our results demonstrate that serotonin, acting through 5-HT 1A receptors, plays an excitatory role in forelimb motor map expression. (jneurosci.org)
- CCK-4 (10 −8 M) but not CCK-8 (10 −8 M) can rapidly reduce the affinity and increase the number of the 3 H-spiperone binding sites linked to 5-HT receptors of the dorsal cerebral cortex of rats. (springer.com)
- Taken together the present findings give evidence that neuropeptide receptors and glutamate receptors can in vitro rapidly modulate the characteristics of different types of DA and 5-HT receptors by way of receptor-receptor interactions at the comodulate level or at the local circuit level. (springer.com)
- Some members of the G protein‐coupled receptor family, specifically several serotonin (5‐HT) receptors, possess eight hydrophobic domains. (deepdyve.com)
- Lyon, R.A., Glennon, R.A. and Titeler, M. 3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective Interactions at Brain 5- HT1 and 5-HT2 Receptors. (ecstasy.org)
- Used collectively, these outcomes recommend that the impact of serotonin on adult neurogenesis in the crustacean mind can be CCNE2 family tree reliant, and that 5-HT2 and 5-HT1 receptors underlie these results. (livingseas.org)
- In arthropods, it is certainly forecasted that at least 18 monoamine receptors can be found , and in crustacean types serotonin receptors accounts for 5 or even more of these [20- (livingseas.org)
- Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. (psychiatryinvestigation.org)
- Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY). (psychiatryinvestigation.org)
- 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors. (psychiatryinvestigation.org)
- In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor (BDNF), and on circulating leptin levels, of male rats. (biomedcentral.com)
- 5-HT1A receptors were quantified by in vitro binding autoradiography. (biomedcentral.com)
- GR and MR receptors are the molecules mediating the negative feedback control exerted by glucocorticoids on HPA axis function [ 5 ]. (biomedcentral.com)
- RU 24969, a 5-HT agonist with highest affinity at 5-HT(1A) and 5-HT(1B) receptors, increased plasma renin activity (PRA) and plasma renin concentration (PRC) as well as plasma corticosterone and prolactin concentrations in a dose-dependent manner. (elsevier.com)
- Inasmuch as 5-HT 2 receptors mediate the serotonergic stimulation of renin secretion, we examined the ability of two selective 5-HT 2 antagonists, ritanserin and LY53857, to inhibit the neuroendocrine effects of RU 24969. (elsevier.com)
- and 4) denervation increases the functional neuroendocrine response to 5-HT agonists which can activate 5-HT(1A), 5-HT(1B) and 5-HT 2 receptors. (elsevier.com)
- These data indicate that the mechanism of EAA involves opioid receptors, and the serotonergic system, particularly, μ -, δ -opioid and 5-HT 1A , 5-HT 3 receptors and it is also dependent on the EAc frequency. (hindawi.com)
- β -Endorphin predominantly synthetized in the arcuate nucleus of the hypothalamus has major analgesic effects via μ -, κ -opioid receptors in the periaqueductal gray region [ 5 ]. (hindawi.com)
- 5-HT effects are conveyed by at least 13 receptors classified in 7 families, 5-HT1 to 5-HT7. (pnas.org)
- These findings suggest that stimulation of central 5-HT release and/or inhibition of 5-HT reuptake play a pivotal role in both the hyperlocomotor and hypothermic effects of mephedrone, which are mediated in part via 5-HT1B and 5-HT1A receptors. (worktribe.com)
- Liu J, Chu YX, Zhang QJ, Wang S, Feng J, Li Q. 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats. (thefullwiki.org)
- The increase in serum prolactin concentration elicited by administration of the serotonergic agonists quipazine or 5-methyxy-N,N-dimethyltryptamine and by the serotonin uptake inhibitor fenfluramine also was potentiated by pretreating rats with 5,7-DHT. (elsevier.com)
- These data suggest that both serotonergic receptor supersensitivity and the absence of presynaptic uptake sites contribute to the enhanced responses to 5-HTP occurring in rats previously treated with 5,7-DHT. (elsevier.com)
- Breese, George R. / Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats . (elsevier.com)
- Age-dependent alterations in hippocampal immunohistochemical localization of glial fibrillary acidic protein and synaptosomal-associated protein were evaluated in female Fischer 344 rats following serotonergic deafferentation with 5,7-dihydroxytryptamine. (cdc.gov)
- Direct cortical application of the 5-HT 1A/7 agonist 8-OH-DPAT lowered movement thresholds in vivo and increased map size in 5-HT-depleted rats. (jneurosci.org)
- In rats, electrical stimulation of the dorsal raphe lowered movement thresholds and this effect could be blocked by direct cortical application of the 5-HT 1A antagonist WAY-100135, indicating that serotonin is primarily acting through the 5-HT 1A receptor. (jneurosci.org)
- Rats that showed the highest withdrawal scores had lower extracellular fluid levels of serotonin (5-HT) compared to rats showing low withdrawal scores. (scirp.org)
- Rats were randomly allocated to 3 groups: Sham group (n=20), DSP-4 [N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine] group (50mg/kg ip, n=18), and DSP-4+5,7-DHT [5,7-dihydroxytryptamine] group (ip DSP-4 50mg/kg+icv 5,7-DHT 200μg, n=18). (sigmaaldrich.com)
- In Sham, DSP-4 and DSP-4+5,7-DHT groups, the effects of ip neurotropin (100NU/Kg) on hot-plate latency in rats with no lesion, noradrenergic neuron depletion and both noradrenergic and serotonergic neuronal depletion were studied, respectively. (sigmaaldrich.com)
- These results demonstrate that 5-HT systems are not directly responsible for the development of the somatic opiate withdrawal syndrome in morphine-dependent rats. (scripps.edu)
- One week after stereotaxic infusions of 5,7-dihydroxy-tryptamine (5,7-DHT, 1.6 micrograms) into the right medial forebrain bundle (MFB), rats received [3H]DOPA (200 microCi,i.v.), which circulated for 90 min. (semanticscholar.org)
- In biochemical study it was shown that analgetics employed in this study (with exception of indomethacin) altered synthesis rate of serotonin (5-HT) and dopamine (DA) in the examined parts of the rats brain. (edu.pl)
- 5. Fink, G., Smith, J.R. & Tibballs, J. (1971) Corticotrophin releasing factor in hypophysial portal blood of rats. (georgefink.com)
- High-speed chronoamperometry was used to determine the kinetics of clearance of exogenously applied serotonin (5-HT) in the dorsal raphe nucleus (DRN), dentate gyrus, CA3 region of the hippocampus or corpus callosum of anesthetized rats. (uthscsa.edu)
- In hippocampal regions of intact rats, local application of the selective serotonin reuptake inhibitor, fluvoxamine, inhibited 5-HT clearance most robustly when the extracellular concentration of 5-HT was less than the K T value. (uthscsa.edu)
- The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion. (psychiatryinvestigation.org)
- Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. (psychiatryinvestigation.org)
- 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. (psychiatryinvestigation.org)
- 5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. (psychiatryinvestigation.org)
- The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation. (psychiatryinvestigation.org)
- For example, IR rats were found more immobile than their social controls in forced swim test (FST, an acknowledged depression paradigm) [ 7 ], indicating a behavioral despair in which the animal gives up to struggle out of a confined distressing situation [ 8 ]. (psychiatryinvestigation.org)
- Adult male Lister hooded rats received three injections of vehicle (1ml/kg, i.p.) or mephedrone HCl (10mg/kg) at 2h intervals for radiotelemetry (temperature and activity) or microdialysis (dopamine and 5-HT) measurements. (worktribe.com)
- Brain norepinephrine and dopamine concentration were not affected by 5-HTP in either group of animals. (elsevier.com)
- On the interaction of 5-hydroxytryptophan and 5-hydroxytryptamine with dopamine metabolism in the rat striatum. (springer.com)
- Both MDMA and MDA, and their respective optical isomers, were assayed as to their affinity at radio-labelled serotonin (5-HT1 and 5-HT2) and dopamine (D2) binding sites. (ecstasy.org)
- We used quantitative autoradiography to measure the contribution of the 5-hydroxytryptamine (5-HT, serotonin) innervation of rat telencephalon to the synthesis of dopamine (DA) from exogenous L-DOPA. (semanticscholar.org)
- A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. (mcmaster.ca)
- Intracerebroventricular pre-treatment (21 to 28 days earlier) with 5,7-dihydroxytryptamine (5,7-DHT, 150μg) or 6-hydroxydopamine (6-OHDA, 300μg) was used to examine the impact of 5-HT or dopamine depletion on mephedrone-induced changes in temperature and activity. (worktribe.com)
- Mephedrone caused rapid-onset hyperactivity, hypothermia (attenuated on repeat dosing), and increased striatal dopamine and 5-HT release following each injection. (worktribe.com)
- Norepinephrine and serotonin in the hippocampus were assayed 1 week after the intracerebroventricular (i.c.v.) administration of 5,7-DHT. (elsevier.com)
- Identification of the 5‐hydroxytryptamine2C receptor as a 60‐kDa N‐glycosylated protein in choroid plexus and hippocampus. (deepdyve.com)
- Earlier studies in this laboratory have shown that partial serotonergic (5-HT) deafferentation from the hippocampus induced a homotypic sprouting. (nyu.edu)
- It also resulted in increased GR/MR ratio, BDNF and 5-HT1A receptor levels in the hippocampus. (biomedcentral.com)
- This release of adenosine and cyclic AMP was reduced after i.t. pretreatment with 5,7-dihydroxytryptamine (100 micrograms) but not 6-hydroxydopamine (100 micrograms). (islandscholar.ca)
- Pretreatment with 5,7-dihydroxytryptamine that resulted in a 90% reduction in 5-HTT density, modestly reduced V max in dentate gyrus but not in CA3. (uthscsa.edu)
- Firstly, chronic depletion of serotonin with the pharmacological agent 5,7-dihydroxytryptamine attenuates neurogenesis [3, (livingseas.org)
- 7 These results are not in agreement with pharmacological studies showing that treatment of AgRP or NPY leads to an increase in food intake. (pubmedcentralcanada.ca)
- The uptake of 5-hydroxytryptamine- 3 H from cerebral ventricles: autoradiographic localization. (springer.com)
- Long-term serotonin changes are blocked by 5-HT re-uptake blockers, and the interactions between MDMA and caffeine have been reported. (ecstasy.org)
- These data indicate that hippocampal uptake of 5-HT may be mediated by two processes, one with high affinity but low capacity (i.e. the 5-HTT) and the other with low affinity but a high capacity (i.e. the NET). (uthscsa.edu)
- the P. clarkii 5-HT2-specific antagonist methiothepin mesylate salt (MMS) suppresses neurogenesis in this region. (livingseas.org)
- By contrast, the NET antagonist, desipramine, significantly inhibited 5-HT clearance when extracellular concentrations of 5-HT were greater than the K T value. (uthscsa.edu)
- Pindobind (0.5 μ g i.t.), a 5-HT 1A antagonist, notably attenuated EAA at different frequencies. (hindawi.com)
- A final study examined the influence of i.p. pre-treatment (-30min) with the 5-HT1A receptor antagonist WAY-100635 (0.5mg/kg), 5-HT1B receptor antagonist GR 127935 (3mg/kg) or the 5-HT7 receptor antagonist SB-258719 (10mg/kg) on mephedrone-induced changes in locomotor activity and rectal temperature. (worktribe.com)
- The lesion-induced reduction of the 5-HT1B autoreceptor-mediated inhibition of evoked 5-HT release may be an adaptation enhancing serotonergic transmission in the (few) remaining terminals. (univoak.eu)
- and on the contrary to lesion the presynaptic 5-HT with 5-HT depletion method by 5,7-dihydroxytryptoamine, 5,7-DHT. (psychiatryinvestigation.org)
- The serotonin concentration in brains of 5,7-DHT-treated animals reached maximum earlier and remained elevated longer than that of controls following administration of 5-HTP. (elsevier.com)
- Additionally, a significant increase in glial fibrillary acidic protein concentration was found by enzyme-linked immunosorbent assay in the 18-month 5,7-dihydroxytryptamine group compared to the 18-month vehicle and three-month 5,7-dihydroxytryptamine groups. (cdc.gov)
- 1988). However, although these measurements might provide information on the steady state concentration of 5-HT, they cannot give any information about the 5-HT synthesis rate. (springer.com)
- Because TPH2-derived serotonin is only a minor portion of total intestinal serotonin, the 5-HT concentration in the duodenum remains unchanged in Tph2 −/− mice ( Table S2 ). (pnas.org)
- Somewhat unexpectedly, older mice were found to be less susceptible to the serotonin-depleting effects of 5,7-DHT. (elsevier.com)
- They also decreased the inhibitory effects of CP-93,129 on the evoked release of [3H]5-HT. (univoak.eu)
- Animal studies on 5-Bromo-DMT showed that it produces effects suggestive of sedative and antidepressant activity and caused significant reduction of locomotor activity in the rodent FST model. (wikipedia.org)
- The mechanism that produces the hallucinogenic and entheogenic effects of 5-MeO-DiPT is thought to result primarily from 5-HT 2A receptor agonism, although additional mechanisms of action such as MAOI may be involved also. (worldheritage.org)
- These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions. (elifesciences.org)
- However, the dominant conception of the 5-HT system still places mood and affect in a central position and considers other actions as side effects. (elifesciences.org)
- To some degree different behavioral effects have been mapped to specific subsets of the 17-member receptor family, but a coherent pharmacologically-grounded theory of 5-HT function centered on affective states has been elusive ( Dayan and Huys, 2009 ). (elifesciences.org)
- A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-microns segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. (uni-bielefeld.de)
- Substance P (SP) (10 −8 M) can rapidly reduce the affinity and increase the density of 3 H-5-HT binding sites in spinal cord membranes. (springer.com)
- These data suggest that i.c.v. morphine activates descending serotonergic pathways to release purines from the spinal cord, and that such release is secondary to release of 5-hydroxytryptamine. (islandscholar.ca)
- Human/ D. melanogaster SERT chimera studies implicated the first two SERT transmembrane domains (TMDs) in the potency of the indole nitrogen-substituted compounds N -isopropyltryptamine (NIT), 5-methoxy- N -isopropyltryptamine (5-MNIT), and the 7-substituted compound 7-benzyloxytryptamine (7BT). (aspetjournals.org)
- significantly more depleted than all known industrially produced organochlorine compounds (delta Cl-37 = -7 to +6 parts per thousand). (diva-portal.org)
- 5-Fwuoro- N , N -dimedywtryptamine ( 5-fwuoro-DMT ) is a tryptamine derivative rewated to compounds such as 5-bromo-DMT and 5-MeO-DMT . (appspot.com)
- "5-Carboxamidotryptamin-Derivate als Liganden für 5-HT 7 - und 5-HT 2A -Rezeptoren: Synthese und In-vitro-Pharmakologie" (in German). (wikipedia.org)
- In previous studies, it was shown that 5-HT release from the spinal dorsal horn was significantly stimulated by somatostatin and substance P in vitro , but not by neurotensin or met-enkephalin [ 11 ]. (hindawi.com)
- Substance P reduces affinity and increases density of 3 H-5-HT binding sites. (springer.com)
- The "R" isomers of both drugs showed a moderate affinity at the 5-HT2 receptor (labelled with 3H ketanserin), and the "S" isomers were lower. (ecstasy.org)
- Apparent affinity (K T ) of the serotonin transporter (5-HTT) was similar in DRN and CA3 but greater in dentate gyrus and corpus callosum. (uthscsa.edu)
- α-Methylserotonin ( αMS ), also known as α-methyl-5-hydroxytryptamine ( α-methyl-5-HT ) or 5-hydroxy-α-methyltryptamine ( 5-HO-αMT ), is a tryptamine derivative closely related to the neurotransmitter serotonin (5-HT). (worldheritage.org)
- 5-Fluoro-α-methyltryptamine ( 5-Fluoro-αMT ) is a tryptamine derivative. (gutenberg.org)