5,7-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.5,6-Dihydroxytryptamine: Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.Dihydroxytryptamines: Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.Serotonin Agents: Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.Iproniazid: An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Raphe Nuclei: Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.p-Chloroamphetamine: Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.Methyltyrosines: A group of compounds that are methyl derivatives of the amino acid TYROSINE.Hydroxyindoleacetic AcidLysergic Acid Diethylamide: Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.Tryptophan Hydroxylase: An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Injections, Intraventricular: Injections into the cerebral ventricles.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Behavior, Animal: The observable response an animal makes to any situation.
7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL ... 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine ... Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic ... 2005). "The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles". Brain ...
7-dihydroxytryptamine MeSH D03.438.473.914.237 --- n,n-dimethyltryptamine MeSH D03.438.473.914.237.150 --- bufotenin MeSH ... 5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 --- 4-chloro-7-nitrobenzofurazan MeSH D03.383. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin ...
7-Dihydroxytryptamine (5,7-DHT) para-Bromoamphetamine (PBA) para-Chlorophenylalanine (PCPA) para-Iodoamphetamine (PIA) 6-CAT ... 44 (5): 329-335. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143. Fuller, R. W.; Baker, J. C. (1974). "Long-lasting ... Gal, E. M.; Cristiansen, P. A.; Yunger, L. M. (1975). "Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in ... Colado, M. I.; Murray, T. K.; Green, A. R. (1993). "5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), ...
7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6- ... 7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... 6-Hydroxydopamine (6-OHDA) para-Chlorophenylalanine (PCPA) Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ability of ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5, ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-HT6. *Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline ... Rizatriptan (trade name Maxalt) is a 5-HT1 receptor agonist of the triptan class of drugs developed by Merck & Co. for the ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... 9 (5): 879-888. doi:10.3390/md9050879. PMC 3111189. PMID 21673896.. *^ Jin-Feng Hu; John A. Schetz; Michelle Kelly; Jiang-Nan ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges Smenospongia ...
Retrieved 5 June 2013.. *^ Guardiola-Lemaître B (December 1997). "Toxicology of melatonin". Journal of Biological Rhythms. 12 ( ... 90 (5): 2755-61. doi:10.1210/jc.2004-2062. PMID 15713707.. *^ Burkhart K, Phelps JR (26 December 2009). "Amber lenses to block ... Retrieved 5 June 2013.. *^ Mills E, Wu P, Seely D, Guyatt G (November 2005). "Melatonin in the treatment of cancer: a ... 7 (5): 423-31. PMID 16729718.. *^ Maestroni GJ (March 2001). "The immunotherapeutic potential of melatonin". Expert Opin ...
7-dihydroxytryptamine on immobility time in mice and rats (Cervo and Samanin, 1991; Borsini, 1995; Redrobe et al., 1998; Page ... 7-dihydroxytryptamine, which completely prevented the rise of extracellular 5-HT (Pozzi et al., 1999). Although 5-HT depletion ... Immobility time in DBA/2J (F(5,49) = 0.3; p , 0.05) and BALB/c (F(3,36) = 1.2; p , 0.05) mice was not affected by any dose of ... Doses of 100 mg · kg-1 · d-1 PCPA for 3 d reduced the accumulation of brain 5-HTP in C57BL/6J (Fig. 5b) and 129/Sv (Fig. 5d) ...
7-methyl-5,6-dihydroxytryptamine: RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the ... Subscribe to New Research on 7-methyl-5,6-dihydroxytryptamine RN & structure given in first source; RN not in Chemline 10/85; ... suitable for elucidating the molecular mechanism of action of 5,6-DHT ...
The effect of 5,6-dihydroxytryptamine on the serotonergic system of the mussel Anodonta cygnea L. / Hiripi, L.; Nemcsók, János ... The effect of 5,6-dihydroxytryptamine on the serotonergic system of the mussel Anodonta cygnea L. Comparative Biochemistry and ... N2 - 1. 1. 5,6-dihydroxytryptamine injected into the foot muscle of Anodonta cygnea results in a 30% decrease in the serotonin ... AB - 1. 1. 5,6-dihydroxytryptamine injected into the foot muscle of Anodonta cygnea results in a 30% decrease in the serotonin ...
7-Difluoro-5,6-dihydroxytryptamine creatinine - Similar structures search, synonyms, formulas, resource links, and other ... 2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one compd. with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ... 1S/C10H10F2N2O2.C4H7N3O.H2O4S/c11-6-5-4(1-2-13)3-14-8(5)7(12)10(16)9(6)15;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h3,14-16H,1-2,13H2;2H2, ... 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-, compd. with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ...
7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Together they form a unique fingerprint. * 5,7- ... 7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age, Brain research, vol. 496, no. 1-2, pp. 251-256. ... 7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. In: Brain research. 1989 ; Vol. 496, No. 1-2. pp. 251 ... 7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. / Finnegan, Kevin T.; DeLanney, Louis E.; Irwin, Ian ...
7-Dihydroxytryptamine • α-ET • α-MT • Aeruginascin • AL-37350A • BW-723C86 • Baeocystin • Bufotenidine • Bufotenin • ... 7-Dihydroxytryptamine (5,7-DHT) is a neurotoxin used to selectively kill serotonergic neurons in scientific research, in the ... 5-HT2C. Agonists: Phenethylamines: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • ... 7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6- ...
5.. Pereira, J.B.A., M.M. Rodrigues, I.R. Morais, C.R.S. Vieira, J.P.M. Sampaio, M.G. Moura, M.F.M. Damasceno, J.N. Silva, I.B. ... 6.. Simoes, E.R.B., E.A. Santos, M.C. Abreu, J.N. Silva, N.M.F. Nunes, M.P. Costa, O.D.L. Pessoa, C. Pessoa, and P.M.P. ... 5.Department of PharmacyFederal University of PiauíTeresinaBrazil. *6.Department of Biophysics and PhysiologyFederal University ... Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-dione. Pharmacological Reports 66: 996-1002.CrossRefPubMed ...
7-Dihydroxytryptamine lesions of crayfish serotonin-containing neurons: effect on the lateral giant escape reaction DL Glanzman ... Journal of Neuroscience 1 June 1986, 6 (6) 1537-1544; DOI: https://doi.org/10.1523/JNEUROSCI.06-06-01537.1986 ... Journal of Neuroscience 1 June 1986, 6 (6) 1545-1552; DOI: https://doi.org/10.1523/JNEUROSCI.06-06-01545.1986 ... Journal of Neuroscience 1 June 1986, 6 (6) 1553-1559; DOI: https://doi.org/10.1523/JNEUROSCI.06-06-01553.1986 ...
6. Similarities between aberrant serotonergic fibers in the aged and 5,7-DHT denervated young adult rat brain VAN LUIJTELAAR M ... Serotonergic sprouting into transplanted C-6 gliomas is blocked by S-100β antisense gene UEDA S. ... Regeneration of serotonergic immunoreactive fibers in the brain of 5,6-dihydroxytryptamine treated rat UEDA S. ... 12/6(木)13:00-19:00、システムメンテナンスに伴い一部サービスが制限されま
7-dihydroxytryptamine administration in the rat. Mol. Pharmacol. 14: 983-995.PubMedGoogle Scholar ... 7-dihydroxytryptamine and related compounds. In Neurotoxin, Fundamental and Clinical Advances, I.W. Chubb, L.B. Geffen eds, ... Evidence for 5-HT1 binding sites on 5-HT containing neurons in the raphe dorsalis and centralis of the rat brain. Neurochem. ... Characteriezation and radioautography of 3H-LSD by rat brain slices in vitro: the effect of 5-hydroxytryptamine. Eur. J. ...
7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology, 73(2), 188-193. ... 7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats, Psychopharmacology, vol. 73, no. 2 ... 7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. / Kuhn, Cynthia M.; Vogel, Richard A ... 7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. In: Psychopharmacology. 1981 ; Vol. ...
7-Dihydroxytryptamine modifies excitability of rat dorsal raphe serotonergic neurons in vitro. Neurosci Lett 71: 306-310Google ... 7-dihydroxytryptamine on serum gonadotropins and prolactin. Ann NY Acad Sci 305: 423-436Google Scholar ... 7-dihydroxytryptamine identifies living dopaminergic neurons in mesencephalic cultures. Proc Natl Acad Sci USA 85: 7346-7350 ... 7-dihydroxytryptamine and briefly viewing the preparation with short exposures to ultraviolet (UV) light (365 nm). Short ...
7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6- ... 7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... 6-Hydroxydopamine (6-OHDA) para-Chlorophenylalanine (PCPA) Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ability of ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5, ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the ...
7-dihydroxytryptamine (5,7-DHT). The retinas were fixed with 2.5% paraformaldehyde and 0.2% glutaraldehyde and inspected by ... Experiments in which 5,7-DHT was applied to retinas incubated in vitro gave identical results. To see the whole shape of the ... To study the cells as a population, we used a new method in which the fluorescence of 5,7-DHT is photochemically converted to ... They have 5-8 radially branching primary dendrites which extend horizontally across the inner plexiform layer before descending ...
Fasmer OB, Berge OG, Hole K (1985) Changes in nociception after lesions of descending serotonergic pathways induced with 5,6- ... dihydroxytryptamine. Different effects in the formalin and tail-flick tests. Neuropharmacology 24:729-734PubMedCrossRefGoogle ... Pak J Pharm Sci 6:45-51PubMedGoogle Scholar ...
7-dihydroxytryptamine on the sexual behavior of gonadectomized male and female rats, Pharmacol. Biochem. Behav. 9:499.Google ... 7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways on the sexual and aggressive behavior of female rats, J ... 5 (E. Stellar and J. M. Sprague, eds.), pp. 253–297, Academic Press, New York.Google Scholar ... Da Prada, M., Carruba, M., OBrien, R. A., Saner, A., and Pletscher, A., 1972, The effect of 5,6-dihydroxytryptamine on sexual ...
7-dihydroxytryptamine during postnatal development. Pharmacol Biochem Behav 23:473-478. ... A, PTZ administered at 30 mg/kg (WT, n= 6; NPY KO, n = 7; DBH KO, n = 6; DKO,n = 6); B, 40 mg/kg (WT, n = 7; NPY KO,n = 8); C, ... Latencies to first myoclonic jerk (MJ) and clonic/tonic (C/T) seizures shown (WT,n = 7; NPY KO, n= 7; DBH KO, n = 6;DKO, n = 7 ... Shown for each animal: no RT (no reverse transcriptase in reaction), undiluted(0.5 μl of RT reaction in PCR reaction), 1:5 (0.5 ...
5.. [The action of the neurotoxins 5,6-dihydroxytryptamine and p-chlorophenylalanine on the electrical activity parameters of ... The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization. ... The role of cyclic 3,5-adenosine monophosphate in the extinction of the reaction of identified neurons in the edible snail to ...
7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL ... 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine ... Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic ... 2005). "The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles". Brain ...
Corrodi H., Farnebo, L.-O., Fuxe, K., Hamberger, B.: Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for ... 6-dihydroxytryptamine or 6-hydroxydopamine. Arch. Int. Pharmacodyn. 217, 118-130 (1975)Google Scholar ... A comparison of drug-induced rotation in rats lesioned in the medial forebrain bundle with 5, ... 5-hydroxytryptamine receptor stimulation. Eur. J. Pharmacol. 30, 172-181 (1975)Google Scholar ...
7-dihydroxytryptamine. The results suggest that central monoaminergic neurons impose both inhibitory and facilitatory ... the ontogeny of the sympatho-adrenomedullary axis was evaluated after neonatal central lesioning with 6-hydroxydopamine or 5, ...
7-dihydroxytryptamine (5,7-DHT) and thalamocortical organization was assayed by application of the carbocyanine dye Di-I to the ... To investigate the role of 5-HT in the development of the somatosensory cortex, this amine was depleted in newborn (P-0) rats ... The 85% depletion of 5-HT did not alter the somatotopic organization of thalamocortical afferents in animals killed on P-6 or P ... These results indicate that 5-HT plays a significant role in the development of the thalamic innervation of the primary ...
7-dihydroxytryptamine (5,7-DHT) into the rostral (AP, -6.3 mm; ML, 0.0 mm; DV, 5.4 mm) and caudal (AP, 7.3 mm; ML, 0.0 mm; DV, ... 7-dihydroxytryptamine into the vPAG caused extensive loss (∼80%) of the serotoninergic cells but not TH-ir cells, and did not ... 5C). In addition, in the brainstem, vPAG axons were found in apposition to ChAT-ir neurons in the LDT (Fig. 6B) but not in the ... 6C), the VLPO (Fig. 7), the perifornical region that contains orexin cells (Fig. 5C), the midline thalamus (Fig. 5B), and the ...
7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei on responding maintained by a DRL 20s schedule of ... 7-dihydroxytryptamine into rodent median raphe nucleus reduced striatal 5-HT and 5-hydroxyindoleacetic acid levels and ... Figure 5. a, b, Brain regions showing greater activation during probabilistic category learning in the whole sample of healthy ... Figure 6. a, b, Brain regions showing greater activation during probabilistic category learning in eight healthy participants ( ...
  • 4-6 Tramadol is rapidly and extensively metabolized by O-demethylation, and one of its major active metabolite O-desmethyltramadol (M1) binds to μ-opioid receptors with high affinity. (asahq.org)
  • Some studies have shown that the blockade of 5-HT2 or 5-HT3 receptors reduce the antinociceptive effect of systemic tramadol. (asahq.org)
  • 3,12,17 In contrast, others have found that the blockade of 5-HT1A increases 15 and the blockade of 5-HT3 receptors did not systemically change tramadol-induced analgesia. (asahq.org)
  • Immunohistochemistry for the detection of 5-bromo-2'-deoxyuridine and doublecortin (DCX) in the hippocampal dentate gyrus and 5-hydroxytryptamine 1A receptors (5-HT(1A)) in the dorsal raphe was conducted. (bvsalud.org)
  • These data indicate that the mechanism of EAA involves opioid receptors, and the serotonergic system, particularly, μ -, δ -opioid and 5-HT 1A , 5-HT 3 receptors and it is also dependent on the EAc frequency. (hindawi.com)
  • β -Endorphin predominantly synthetized in the arcuate nucleus of the hypothalamus has major analgesic effects via μ -, κ -opioid receptors in the periaqueductal gray region [ 5 ]. (hindawi.com)
  • Enkephalins are ligands of both μ and δ receptors [ 6 - 8 ]. (hindawi.com)
  • were inhibited in the ipsilateral lamina I/II by 5-HT 1/2B/2C (methysergide), 5-HT 2A (ketanserin) or 5-HT 1/2A/2C/5/6/7 (methiothepin) receptors antagonists, in the ipsilateral lamina V by methysergide or methiothepin, in the contralateral lamina V by all the serotonergic antagonists and in the lamina X by LY 278,584, ketanserin or methiothepin. (biomedcentral.com)
  • These results suggest that CRFR2 are required for proper functionality of 5-HT 1A receptors in the raphe nuclei, and are key to successful recovery from stress. (biomedcentral.com)
  • In contrast to the well-characterized effects of 5-HT agonists in the circadian system, little is known concerning the regulation of endogenous 5-HT release in the SCN. (jneurosci.org)
  • In addition to these main contributions, cholinergic 6 and dopaminergic 7 systems have also been shown to be involved in acetaminophen analgesia. (turkjps.org)
  • 5-Fluoro-α-methyltryptamine ( 5-Fluoro-αMT ) is a tryptamine derivative. (gutenberg.org)
  • 5-methoxy-diisopropyltryptamine ( 5-MeO-DiPT ), often termed Foxy Methoxy or just Foxy , is a tryptamine psychedelic used as a recreational drug. (worldheritage.org)
  • Tryptamine derivatives with substitutions at the 4 and 7 positions on the phenyl ring, the indole nitrogen, and the β position show up to 40-fold potency differences for inhibiting [ 3 H]5-HT transport in cells transfected with either human or Drosophila melanogaster SERT cDNAs. (aspetjournals.org)
  • Brain norepinephrine and dopamine concentration were not affected by 5-HTP in either group of animals. (elsevier.com)
  • On the interaction of 5-hydroxytryptophan and 5-hydroxytryptamine with dopamine metabolism in the rat striatum. (springer.com)
  • Among invertebrates, the most common catecholamine is dopamine, while adrenaline and noradrenaline are rare (6). (scielo.br)
  • In a pharmacological review of rhythmic behaviors such as locomotion or breathing, the modulatory role of 5-HT is noteworthy in the control of locomotion (8,10) and feeding (11-13), while dopamine has been reported to play a role in breathing (14). (scielo.br)
  • These data suggest that i.c.v. morphine activates descending serotonergic pathways to release purines from the spinal cord, and that such release is secondary to release of 5-hydroxytryptamine. (islandscholar.ca)
  • Effects of milnacipran, a 5-HT and noradrenaline reuptake inhibitor, on C-fibre-evoked field potentials in spinal long-term potentiation and neuropathic pain. (semanticscholar.org)
  • In previous studies, it was shown that 5-HT release from the spinal dorsal horn was significantly stimulated by somatostatin and substance P in vitro , but not by neurotensin or met-enkephalin [ 11 ]. (hindawi.com)
  • Chronic use leads to desensitization of somatodendritic 5-HT 1A and terminal autoreceptors. (t3db.ca)
  • Systemic application of the somatodendritic 5-HT 1A agonist BMY 7378 had a significantly greater suppressive effect on 5-HT release in the SCN during the late dark phase compared with mid light phase, indicating that a variation in raphe autoreceptor response may underlie the time-dependent effects of wheel running on 5-HT release. (jneurosci.org)
  • Offspring also showed reduced expression of BDNF, TrkB, and DCX in the dentate gyrus, decreased cell proliferation in the hippocampus, and reduced 5-HT(1A) expression in the dorsal raphe. (bvsalud.org)
  • Cairncross KD, Cox B, Forster C, Wren A. The ability of local injection of 6-OHDA, 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat. (thefullwiki.org)
  • Metabolism of 5-hydroxytryptophan- 14 C after intracisternal injection with and without the influence of drugs in the rat brain. (springer.com)
  • Therefore, most oxy-cholesterols hydroxy-5-cholestenonic acid. (pdfdrug.com)
  • 2-aminomethyl-5-hydroxy-4h-pyran-4-one), a compound which shares some structural features with gamma-aminobutyric acid (gaba) and muscimol, has been examined in a variety of test systems for gabamimetic activity. (liverpool.ac.uk)
  • The OL is usually the primary olfactory … Several lines of evidence 147254-64-6 indicate that serotonergic pathways influence adult neurogenesis in decapod crustaceans. (livingseas.org)
  • Locomotor activity induced by exposure to a novel running wheel had a pronounced phase-dependent effect on 5-HT release in the SCN, with stimulation during the light phase and suppression during the late dark phase. (jneurosci.org)
  • A significant correlation was found between Kd values and Ki values at competing for 3H-ketanserin binding (R = 0.98), suggesting that the phosphoinositide- linked receptor and the 5-HT-2 site are identical. (jneurosci.org)
  • Despite the critical role of SERT in 5-HT inactivation and psychostimulant response, many aspects of the transporter's recognition of ligands are poorly defined. (aspetjournals.org)
  • These latter results suggest that it is the A form of MAO that plays an important role in the mechanism of 5,7-DHT-induced noradrenergic toxicy. (elsevier.com)
  • The mechanism that produces the hallucinogenic and entheogenic effects of 5-MeO-DiPT is thought to result primarily from 5-HT 2A receptor agonism, although additional mechanisms of action such as MAOI may be involved also. (worldheritage.org)
  • Not only has decreased prostaglandin production via cyclooxygenase (COX) enzyme inhibition (especially COX-2, and a central splice variant of COX-1, which is COX-3) been proposed as the primary mechanism of analgesic action, 1,2,3 but also the contribution of cannabinoidergic 4 and opioidergic 5 systems has been shown. (turkjps.org)