Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.
Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.
Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Decarboxylated monoamine derivatives of TRYPTOPHAN.
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
Injections into the cerebral ventricles.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
The observable response an animal makes to any situation.
Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.
Substances that reduce or suppress INFLAMMATION.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Drinkable liquids containing ETHANOL.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Farzam, Ali; Chohan, Karan; Strmiskova, Miroslava; Hewitt, Sarah ... 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine ... Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL (2005). "The neonate-6-hydroxydopamine-lesioned rat: a model ... However, recent research suggests that 6-OHDA modifies proteins via cysteine modification, implying an additional cause of ...
... isoform 5 is the longest mRNA and is 2,429 bp long. The shortest isoform is variant 4 and this variant is 2,035 bp long ... These enhancer sites come on the 5' end of the TMEM155 gene and contain binding sites for transcription factors RCOR1, MILLT1, ... This gene spans from base pairs 121,758,930 and 121,765,427 on chromosome 4. The longest variant ofTMEM155 has 5 exons detailed ... Renaud B, Buda M, Lewis BD, Pujol JF (September 1975). "Effects of 5,6-dihydroxytryptamine on tyrosine-hydroxylase activity in ...
23 (5): 627-634. doi:10.1037/a0015568. PMC 2808210. PMID 19702416. Saults, J. S.; Cowan, N.; Sher, K. J.; Moreno, M. V. (2007 ... 14 (5): 1066-1074. doi:10.1111/j.1467-7687.2011.01060.x. PMC 3177168. PMID 21884322. Cowan, N.; Ricker, T. J.; Clark, K. M.; ... 15 (6): 576-587. doi:10.1037/1064-1297.15.6.576. PMC 2658822. PMID 18179311. Bartholow, B. D.; Fleming, K. A.; Wood, P. K.; ... 143 (5): 1806-1836. doi:10.1037/a0036814. PMC 4172497. PMID 24867488. Cowan, N.; Li, D.; Moffitt, A.; Becker, T. M.; Martin, E ...
... , also known as 4-HO-5-MeO-DMT or psilomethoxin, is a novel psychedelic drug. It is the 4- ... Though this method has never been explored with 5-MeO-DMT, it has been used successfully for changing DET into 4-HO-DET and 4- ... 29 (6): 347-52. doi:10.1002/jobm.3620290608. PMID 2614674. Björklund A, Nobin A, Stenevi U (December 1973). "The use of ... This paper reports a 10 step synthesis of 4-HO-5-MeO-DMT from ortho-vanillin. However, Alexander Shulgin has explained that it ...
7-dihydroxytryptamine MeSH D03.438.473.914.237 - N,N-Dimethyltryptamine MeSH D03.438.473.914.237.150 - bufotenin MeSH D03.438. ... 5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6- ... 7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... DSP-4 6-Hydroxydopamine (6-OHDA) para-Chlorophenylalanine (PCPA) Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5, ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the ...
7-Dihydroxytryptamine (5,7-DHT) para-Bromoamphetamine (PBA) para-Iodoamphetamine (PIA) Miller, K. J.; Anderholm, D. C.; Ames, M ... 44 (5): 329-335. doi:10.1111/j.1600-0773.1979.tb02339.x. PMID 474143. Fuller, R. W.; Baker, J. C. (1974). "Long-lasting ... Gal, E. M.; Cristiansen, P. A.; Yunger, L. M. (1975). "Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in ... Colado, M. I.; Murray, T. K.; Green, A. R. (1993). "5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... 9 (5): 879-888. doi:10.3390/md9050879. PMC 3111189. PMID 21673896.. *^ Jin-Feng Hu; John A. Schetz; Michelle Kelly; Jiang-Nan ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges Smenospongia ...
Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substituted benzofurans, MDAI, MDMA). ... InChI=1S/C18H26N2O2/c1-12(2)20(13(3)4)10-9-15-11-19-16-7-6-8-17(18(15)16)22-14(5)21/h6-8,11-13,19H,9-10H2,1-5H3 ... InChI=1/C18H26N2O2/c1-12(2)20(13(3)4)10-9-15-11-19-16-7-6-8-17(18(15)16)22-14(5)21/h6-8,11-13,19H,9-10H2,1-5H3 ... 7-Dihydroxytryptamine. *5-BT. *5-Bromo-DMT. *5-CT. *5-Chloro-αMT ...
5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... 5-HT6. *Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline ... Rizatriptan acts as an agonist at serotonin 5-HT1B and 5-HT1D receptors.[11] Like the other triptans sumatriptan and ...
Retrieved 5 June 2013.. *^ Guardiola-Lemaître B (December 1997). "Toxicology of melatonin". Journal of Biological Rhythms. 12 ( ... 90 (5): 2755-61. doi:10.1210/jc.2004-2062. PMID 15713707.. *^ Burkhart K, Phelps JR (26 December 2009). "Amber lenses to block ... Retrieved 5 June 2013.. *^ Mills E, Wu P, Seely D, Guyatt G (November 2005). "Melatonin in the treatment of cancer: a ... 7 (5): 423-31. PMID 16729718.. *^ Maestroni GJ (March 2001). "The immunotherapeutic potential of melatonin". Expert Opin ...
7-methyl-5,6-dihydroxytryptamine: RN & structure given in first source; RN not in Chemline 10/85; suitable for elucidating the ... Subscribe to New Research on 7-methyl-5,6-dihydroxytryptamine RN & structure given in first source; RN not in Chemline 10/85; ... suitable for elucidating the molecular mechanism of action of 5,6-DHT ...
The effect of 5,6-dihydroxytryptamine on the serotonergic system of the mussel Anodonta cygnea L. / Hiripi, L.; Nemcsók, János ... The effect of 5,6-dihydroxytryptamine on the serotonergic system of the mussel Anodonta cygnea L. Comparative Biochemistry and ... N2 - 1. 1. 5,6-dihydroxytryptamine injected into the foot muscle of Anodonta cygnea results in a 30% decrease in the serotonin ... AB - 1. 1. 5,6-dihydroxytryptamine injected into the foot muscle of Anodonta cygnea results in a 30% decrease in the serotonin ...
7-Difluoro-5,6-dihydroxytryptamine creatinine - Similar structures search, synonyms, formulas, resource links, and other ... 2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one compd. with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ... 1S/C10H10F2N2O2.C4H7N3O.H2O4S/c11-6-5-4(1-2-13)3-14-8(5)7(12)10(16)9(6)15;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h3,14-16H,1-2,13H2;2H2, ... 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-, compd. with 3-(2-aminoethyl)-4,7-difluoro-1H-indole-5,6-diol sulfate (1:1:1) ...
7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Together they form a unique fingerprint. * 5,7- ... 7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age, Brain research, vol. 496, no. 1-2, pp. 251-256. ... 7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. In: Brain research. 1989 ; Vol. 496, No. 1-2. pp. 251 ... 7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. / Finnegan, Kevin T.; DeLanney, Louis E.; Irwin, Ian ...
7-dihydroxytryptamine. 5-HT. 5-hydroxytryptamine. CPu. caudate-putamen. GABA. γ-aminobutyric acid. ... 7-Dihydroxytryptamine lesion of serotonergic cells and processes produced no changes in [125I]7-OH-PIPAT binding. These results ... S-3-iodo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5,6-dimethoxysalicylamide. p-MPPI. 4-(2′-methoxyphenyl)-1-[2′-(n-2"-pyridinyl)-p- ... JPET articles become freely available 12 months after publication, and remain freely available for 5 years. Non-open access ...
7-Dihydroxytryptamine • α-ET • α-MT • Aeruginascin • AL-37350A • BW-723C86 • Baeocystin • Bufotenidine • Bufotenin • ... 7-Dihydroxytryptamine (5,7-DHT) is a neurotoxin used to selectively kill serotonergic neurons in scientific research, in the ... 5-HT2C. Agonists: Phenethylamines: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • ... 7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6- ...
5.. Pereira, J.B.A., M.M. Rodrigues, I.R. Morais, C.R.S. Vieira, J.P.M. Sampaio, M.G. Moura, M.F.M. Damasceno, J.N. Silva, I.B. ... 6.. Simoes, E.R.B., E.A. Santos, M.C. Abreu, J.N. Silva, N.M.F. Nunes, M.P. Costa, O.D.L. Pessoa, C. Pessoa, and P.M.P. ... 5.Department of PharmacyFederal University of PiauíTeresinaBrazil. *6.Department of Biophysics and PhysiologyFederal University ... Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-dione. Pharmacological Reports 66: 996-1002.CrossRefPubMed ...
7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology, 73(2), 188-193. ... 7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats, Psychopharmacology, vol. 73, no. 2 ... 7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. / Kuhn, Cynthia M.; Vogel, Richard A ... 7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. In: Psychopharmacology. 1981 ; Vol. ...
7-Dihydroxytryptamine lesions of crayfish serotonin-containing neurons: effect on the lateral giant escape reaction DL Glanzman ... Journal of Neuroscience 1 June 1986, 6 (6) 1537-1544; DOI: https://doi.org/10.1523/JNEUROSCI.06-06-01537.1986 ... Journal of Neuroscience 1 June 1986, 6 (6) 1545-1552; DOI: https://doi.org/10.1523/JNEUROSCI.06-06-01545.1986 ... Journal of Neuroscience 1 June 1986, 6 (6) 1553-1559; DOI: https://doi.org/10.1523/JNEUROSCI.06-06-01553.1986 ...
7-Dihydroxytryptamine DSP-4 MPTP Norsalsolinol Rotenone FAUC50 Farzam, Ali; Chohan, Karan; Strmiskova, Miroslava; Hewitt, Sarah ... 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine ... Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL (2005). "The neonate-6-hydroxydopamine-lesioned rat: a model ... However, recent research suggests that 6-OHDA modifies proteins via cysteine modification, implying an additional cause of ...
6. Similarities between aberrant serotonergic fibers in the aged and 5,7-DHT denervated young adult rat brain VAN LUIJTELAAR M ... Serotonergic sprouting into transplanted C-6 gliomas is blocked by S-100β antisense gene UEDA S. ... Regeneration of serotonergic immunoreactive fibers in the brain of 5,6-dihydroxytryptamine treated rat UEDA S. ... 12/6(木)13:00-19:00、システムメンテナンスに伴い一部サービスが制限されま
7-dihydroxytryptamine administration in the rat. Mol. Pharmacol. 14: 983-995.PubMedGoogle Scholar ... 7-dihydroxytryptamine and related compounds. In Neurotoxin, Fundamental and Clinical Advances, I.W. Chubb, L.B. Geffen eds, ... Evidence for 5-HT1 binding sites on 5-HT containing neurons in the raphe dorsalis and centralis of the rat brain. Neurochem. ... Characteriezation and radioautography of 3H-LSD by rat brain slices in vitro: the effect of 5-hydroxytryptamine. Eur. J. ...
7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine and NE levels, respectively, but had no effect ... 7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine and NE levels, respectively, but had no effect ... 7-dihydroxytryptamine but increased by 6-hydroxydopamine. Subcutaneous pretreatment of neonatal or intrathecal pretreatment of ... 7-dihydroxytryptamine but increased by 6-hydroxydopamine. Subcutaneous pretreatment of neonatal or intrathecal pretreatment of ...
7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6- ... 7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin ... DSP-4 6-Hydroxydopamine (6-OHDA) para-Chlorophenylalanine (PCPA) Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ... Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5, ... 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the ...
Articles in CiNii:5. * Cooling Characteristics of C/C Composite Material Structure with a Metallic Tube Fixed by Elastic Forces ... Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory ... Effect of 5, 6-dihydroxytryptamine (5, 6-DHT) on the ascending serotonergic neuron system : An immunohistochemical study : ( ... Syntheses and antitumor activities of compounds related to 1-(tetrahydro-2-furanyl)-5-fluorouracil metabolites. (1982) ...
7-dihydroxytryptamine (5,7-DHT). The retinas were fixed with 2.5% paraformaldehyde and 0.2% glutaraldehyde and inspected by ... Experiments in which 5,7-DHT was applied to retinas incubated in vitro gave identical results. To see the whole shape of the ... To study the cells as a population, we used a new method in which the fluorescence of 5,7-DHT is photochemically converted to ... They have 5-8 radially branching primary dendrites which extend horizontally across the inner plexiform layer before descending ...
7-dihydroxytryptamine); n = 4 (uninjured), 6 (7 dpi), 11 to 12 rats (56 and 70 dpi) per group. (E) Number of footfalls on the ... Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain 130, 1819-1833 ( ... 5Jülich-Aachen Research Alliance-Translational Brain Medicine.. *. 6Institute of Reconstructive Neurobiology, Life&Brain Center ... 6Institute of Reconstructive Neurobiology, Life&Brain Center, University of Bonn and Hertie Foundation, Sigmund-Freud-Strasse ...
5.. [The action of the neurotoxins 5,6-dihydroxytryptamine and p-chlorophenylalanine on the electrical activity parameters of ... The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization. ... The role of cyclic 3,5-adenosine monophosphate in the extinction of the reaction of identified neurons in the edible snail to ...
7-dihydroxytryptamine. The results suggest that central monoaminergic neurons impose both inhibitory and facilitatory ... the ontogeny of the sympatho-adrenomedullary axis was evaluated after neonatal central lesioning with 6-hydroxydopamine or 5, ...
7-dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding in rat brain. Neuroendocrinology 1994 / ... 1998 / 9 (5) / 433-440. (12) Adamczyk, M et al, Inhibition of p42/p44 mitogen-activated protein kinase by oxysterols in rat ... 5) Vorster, H.H. et al, Egg intake does not change plasma lipoprotein and coagulation profile. Am. J. Clin. Nutr., 1992 / 55 (2 ... 4.921.710 / 1-5-1990. (28) Pfeiffer, E.H. The carcinogenity of coprosterol, an intestinal reduction product of cholesterol (in ...
7-dihydroxytryptamine (serotonergic neurons), ibotenic acid [N-methyl-D-aspartate (NMDA) receptor-containing neurons], kainic ... 6. Conclusion. Alcohol is a widely used legal intoxicant that produces a huge financial toll ($223.5 billion in 2006 alone) on ... 5. Neural structures involved in ethanol-seeking behavior. In the following sections, several neural structures and circuits ... Popular neurotransmitter-specific lesioning agents include 6-hydroxydopamine (dopaminergic and noradrenergic neurons), 5, ...
7-dihydroxytryptamine [6]. In addition, spinal pretreatment of rats with WAY-100,635, a 5-HT1A receptor antagonist and ... 7-dihydroxytryptamine [39]. Studies showing that paracetamol did not bind serotonin receptors [38, 40] prompted investigation ... 6. Conclusion. All these recent findings prompt us to propose a novel view of paracetamol as a prodrug that needs to overcome a ... Later studies showed that the spinal role of 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptor subtypes of serotonin receptors was ...
Wang X et al (2010b) Spinocerebellar ataxia type 6: systematic patho-anatomical study reveals different phylogenetically ... 6-dihydroxytryptamine lesioning. J Neurocytol 16:155-167PubMedCrossRefPubMedCentralGoogle Scholar ... Front Neural Circuits 6:91. https://doi.org/10.3389/fncir.2012.00091CrossRefPubMedPubMedCentralGoogle Scholar ... Nat Rev Neurosci 6:351-U317. https://doi.org/10.1038/Nrn1665CrossRefPubMedPubMedCentralGoogle Scholar ...
7-dihydroxytryptamine (5,7-DHT; 150 micro g) and, 15 days later, to intrahippocampal grafts of fetal raphe cell suspensions. ... 7-dihydroxytryptamine (5,7-DHT; 150 micro g) and, 15 days later, to intrahippocampal grafts of fetal raphe cell suspensions. ... 7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal ... 7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal ...
7-dihydroxytryptamine blocks the antinociception induced by endomorphin-1 and endomorphin-2 given intracerebroventricularly in ... 5. The effects of an intrathecal injection of ondansetron (20 μg) on systemic tramadol-induced ( A ) and O-desmethyltramadol ( ... 5. The effects of an intrathecal injection of ondansetron (20 μg) on systemic tramadol-induced ( A ) and O-desmethyltramadol ( ... 5. The effects of an intrathecal injection of ondansetron (20 μg) on systemic tramadol-induced ( A ) and O-desmethyltramadol ( ...
7-dihydroxytryptamine lesions of the nucleus accumbens on rat intravenous morphine self-administration. Zhou, F. C. & Azmitia, ... Terhune, K. P., Joshi, A. R. T. & Choi, J., Jun 2020, In : Surgery (United States). 167, 6, p. 899-902 4 p.. Research output: ... Culnan, D. M. & Sood, R., Oct 23 2018, In : Journal of Burn Care and Research. 39, 6, p. 1053-1057 5 p.. Research output: ... Chai, Z., Fan, H., Li, Y., Song, L., Jin, X., Yu, J., Li, Y., Ma, C. & Zhou, R., Nov 2017, In : Oncology reports. 38, 5, p. ...
7-Dihydroxytryptamine * 5-(Nonyloxy)tryptamine * 6-Fluoro-αMT * 7-Methyl-αET ... α-Methylserotonin (αMS), also known as α-methyl-5-hydroxytryptamine (α-methyl-5-HT) or 5-hydroxy-α-methyltryptamine (5-HO-αMT ... Note that the 5-HT5B receptor is not functional in humans. ... 5] The O-methylated analogue of αMS, 5-MeO-αMT, also readily ... 2-Methyl-5-hydroxytryptamine Encyclopedia Article. 5-Carboxamidotryptamine, 5-Methoxytryptamine, Metitepine, Lysergic acid ...
Matsunaga, K., Sakai, K., Hiramatsu, M., Yazaki, K. & Ueda, H., 1980, In : Nishi Nihon Hifuka. 42, 5, p. 791-795 5 p.. Research ... Nabeshima, T. & Ho, I. K., 1981, In : Progress in Neuro-Psychopharmacology. 5, 4, p. 373-381 9 p.. Research output: ... Tsutomu, K. & Toshitaka, N., 01-01-1978, In : Neuropharmacology. 17, 4-5, p. 249-256 8 p.. Research output: Contribution to ... Kameyama, T., Shigehisa, T. & Nabeshima, T., 01-01-1975, In : The Japanese Journal of Pharmacology. 25, 6, p. 784-787 4 p.. ...
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  • The intracisternal administration of 5,7-dihydroxytryptamine (5,7-DHT) to rats resulted in a potentiated response to 5-hydroxytryptophan (5-HTP) when the animals were tested 30 days later. (elsevier.com)
  • The increase in serum prolactin concentration elicited by administration of the serotonergic agonists quipazine or 5-methyxy-N,N-dimethyltryptamine and by the serotonin uptake inhibitor fenfluramine also was potentiated by pretreating rats with 5,7-DHT. (elsevier.com)
  • These data suggest that both serotonergic receptor supersensitivity and the absence of presynaptic uptake sites contribute to the enhanced responses to 5-HTP occurring in rats previously treated with 5,7-DHT. (elsevier.com)
  • Breese, George R. / Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats . (elsevier.com)
  • Liu J, Chu YX, Zhang QJ, Wang S, Feng J, Li Q. 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats. (thefullwiki.org)
  • In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. (fujita-hu.ac.jp)
  • In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. (fujita-hu.ac.jp)
  • Mechanism of pressor effect of 5,6-dihydroxytryptamine in pithed rats. (lixghtiislland16.ga)
  • Adult male Lister hooded rats received three injections of vehicle (1ml/kg, i.p.) or mephedrone HCl (10mg/kg) at 2h intervals for radiotelemetry (temperature and activity) or microdialysis (dopamine and 5-HT) measurements. (worktribe.com)
  • The ciliary nerve endings of adult albino rats were observed by transmission electron microscopy after the injection of 5,6-dihydroxytryptamine. (pianolarge.ga)
  • 5. Fink, G., Smith, J.R. & Tibballs, J. (1971) Corticotrophin releasing factor in hypophysial portal blood of rats. (georgefink.com)
  • High-speed chronoamperometry was used to determine the kinetics of clearance of exogenously applied serotonin (5-HT) in the dorsal raphe nucleus (DRN), dentate gyrus, CA3 region of the hippocampus or corpus callosum of anesthetized rats. (uthscsa.edu)
  • In hippocampal regions of intact rats, local application of the selective serotonin reuptake inhibitor, fluvoxamine, inhibited 5-HT clearance most robustly when the extracellular concentration of 5-HT was less than the K T value. (uthscsa.edu)
  • In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor (BDNF), and on circulating leptin levels, of male rats. (biomedcentral.com)
  • control = 17.1 × 10 -8 M). Contractile responses to 5-hydroxyindole acetic acid and 5-hydroxytryptophol were greater in mesenteric arteries from hypertensive rats, whereas reactivity to 5-methoxytryptamine and melatonin in arteries from hypertensive rats did not differ from that in arteries from normotensive rats. (elsevier.com)
  • Contractile responses to 5,6-dihydroxytryptamine and 6-hydroxytryptamine were greater in mesenteric arteries from hypertensive rats, whereas responsiveness to 3-hydroxytryptamine in hypertensive arteries did not differ from normotensive values. (elsevier.com)
  • In 1991, the antinociceptive effect of acetaminophen in a formalin test was reduced following the chemical impairment of spinal serotonergic pathways (bulbospinal serotonergic pathway) by intrathecal 5,6-dihydroxytryptamine (5,6-DHT) administration in rats. (turkjps.org)
  • The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. (elsevier.com)
  • Lactating rats on PPD 5, in the presence of their pups, were divided into four groups: (1) no social instigation and no aggressive behavior, (2) social instigation and no aggressive behavior, (3) no social instigation and aggressive behavior, and (4) social instigation and aggressive behavior. (bvsalud.org)
  • In the following 5 days rats were injected (s.c.) with vehicle, nicotine, or WIN 55,212-2. (plcsignaling.com)
  • Danitracen pretreatment led to a lowering in the 5-HIAA levels in the whole brain and decreased NE levels in apomorphine and amphetamine treated rats. (bvsalud.org)
  • Three weeks after rats were given multiple administrations of METH (5-10 mg/kg, four times at 2-h intervals), dose-related decreases in DA tissue content in striatum and tyrosine hydroxylase mRNA in the substantia nigra pars compacta were observed. (aspetjournals.org)
  • One week after stereotaxic infusions of 5,7-dihydroxy-tryptamine (5,7-DHT, 1.6 micrograms) into the right medial forebrain bundle (MFB), rats received [3H]DOPA (200 microCi,i.v.), which circulated for 90 min. (semanticscholar.org)
  • Since the effects of 5,7-DHT on noradrenergic neurons may, at leastin part, depend on the monoamine oxidase (MAO)-generated formation of hydrogen peroxide and associated oxy-radicals,this result suggests that noradrenergic neurons do not become more vulnerable to oxidative stress with aging. (elsevier.com)
  • Although the mechanism by whichthis compound damages serotonergic neurons is uncertain, our results show that the increased susceptibility of serotonergic neurons to 5,7-DHT in young animals extends well beyond the neonatal period. (elsevier.com)
  • Lesion of dopaminergic neurons with 6-hydroxydopamine produced 50% decreases in [ 125 I]7-OH-PIPAT binding in the nucleus accumbens and substantia nigra. (aspetjournals.org)
  • The findings further demonstrate that both behavioral and hormonal measures can be used to assess the sensitivity of serotonergic receptors and indicate that 5,7-DHT may be useful in evaluating the role of serotonergic neurons in neuroendocrine function. (elsevier.com)
  • 5,7-Dihydroxytryptamine ( 5,7-DHT ) is a neurotoxin used to selectively kill serotonergic neurons in scientific research, in the same way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells . (thefullwiki.org)
  • Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. (wikipedia.org)
  • 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. (wikipedia.org)
  • The mechanism behind this effect isn't well understood, but many believe (without clear substantiation) that it selectively kills serotonergic neurons, in a similar way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells. (wikipedia.org)
  • The indoleamine-accumulating neurons of the rabbit retina were labeled by intraocular injection of 5,7-dihydroxytryptamine (5,7-DHT). (jneurosci.org)
  • The action of the neurotoxins 5,6-dihydroxytryptamine and p-chlorophenylalanine on the electrical activity parameters of the command neurons during long-term sensitization and learning in the snail]. (nih.gov)
  • The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization. (nih.gov)
  • These results confirm that grafts rich in serotonergic neurons may partially compensate for the dramatic effects of 5,7-DHT lesions on serotonergic hippocampal functions. (univoak.eu)
  • This study examined the effects of repeated mephedrone administration on locomotor activity, body temperature and striatal dopamine and 5-hydroxytryptamine (5-HT) levels, and the role of dopaminergic and serotonergic neurons in these responses. (worktribe.com)
  • Adult neurogenesis, the creation of functionally integrated neurons in the teen and adult mind, is usually a common feature in a variety of species, from insects and crustaceans to birds and mammals [5]. (livingseas.org)
  • 1975. Effects of 5,6-dihydroxytryptamine on tyrosine-hydroxylase activity in central catecholaminergic neurons of the rat. . (chavi-id.org)
  • To measure the analgesic and anti-depressant effects of NTP, either K252a (a tyrosine kinase inhibitor), or 5,7-dihydroxy tryptamine (5,7-DHT, a selective toxin for 5-HTergic neurons) was administered by intracerebroventricular injection. (springer.com)
  • When the locomotor-like activity was induced by applying neuroactive drugs selectively over the lumbar spinal cord, light stimulation (continuous illumination for 5-10 s, - nm) of V2a brainstem neurons did not significantly alter the ongoing locomotor frequency (A, C). The effect of low doses of urethane on three phases of spinal seizures evoked by sudden cooling (SSSC) of toad isolated spinal cord was studied. (poldasulteng.com)
  • In gastropods, dopamine is also the principal catecholamine and there is no evidence that the neurons are capable of synthesizing other catecholamines (6,9). (scielo.br)
  • 5) α-adrenergic receptors are unlikely to participate in the incision-induced facilitation of the spinal neurons. (biomedcentral.com)
  • The principal sources of 5-HT neurons projecting to the forebrain are the midbrain dorsal (DRN) and median (MRN) raphe nuclei [ 3 , 4 ]. (biomedcentral.com)
  • The effect of 5,6-dihydroxytryptamine on the serotonergic system of the mussel Anodonta cygnea L. (elsevier.com)
  • These results complement previous findings with microinjection of serotonin 5-hydroxytryptamine-1B receptor agonists into the same region, demonstrating that the VO PFC is an important region in the modulation of maternal aggressive behavior. (bvsalud.org)
  • LSD, lisuride, 2-methyl-5-HT, tryptamine and 5-benzyloxytryptamine behaved as partial agonists relative to 5-HT. (meta.org)
  • Serotonin neurotoxins: Effects of drugs on the destruction of brain serotoninergic, noradrenergic and dopaminergic axons in adult rat by intraventricularly, intracisternally or intracerebrally administered 5,7-dihydroxytryptamine and related compounds. (springer.com)
  • α-Methylserotonin ( αMS ), also known as α-methyl-5-hydroxytryptamine ( α-methyl-5-HT ) or 5-hydroxy-α-methyltryptamine ( 5-HO-αMT ), is a tryptamine derivative closely related to the neurotransmitter serotonin (5-HT). (worldheritage.org)
  • 5-Fluoro-α-methyltryptamine ( 5-Fluoro-αMT ) is a tryptamine derivative. (gutenberg.org)
  • 5-methoxy-diisopropyltryptamine ( 5-MeO-DiPT ), often termed Foxy Methoxy or just Foxy , is a tryptamine psychedelic used as a recreational drug. (worldheritage.org)
  • A variety of tryptamine derivatives were tested and showed a significantly higher affinity when the 5-HT6 receptor was labelled with [3H]-5-HT, whereas ergoline compounds and several antagonists had higher affinities when [3H]-LSD was used as radioligand. (meta.org)
  • Subsequently we examined the ability of LSD, 5-HT and a number of tryptamine derivatives to stimulate cAMP accumulation in order to determine their agonist potency and efficacy. (meta.org)
  • Tryptamine derivatives with substitutions at the 4 and 7 positions on the phenyl ring, the indole nitrogen, and the β position show up to 40-fold potency differences for inhibiting [ 3 H]5-HT transport in cells transfected with either human or Drosophila melanogaster SERT cDNAs. (aspetjournals.org)
  • In addition to these main contributions, cholinergic 6 and dopaminergic 7 systems have also been shown to be involved in acetaminophen analgesia. (turkjps.org)
  • NE-evoked release of adenosine was unaffected by 5,7-dihydroxytryptamine but increased by 6-hydroxydopamine. (unboundmedicine.com)
  • In vitro pretreatment of isolated ganglia with 5,6-dihydroxytryptamine selectively inhibits the serotonin accumulation. (elsevier.com)
  • Intrathecal pretreatment with 5,7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine and NE levels, respectively, but had no effect on adenosine release from dorsal spinal cord synaptosomes evoked by K+ or morphine. (unboundmedicine.com)
  • Exposure of dorsal, but not ventral, spinal cord synaptosomes to capsaicin produced a dose- and Ca++-dependent release of adenosine, which was reduced by capsaicin pretreatment (neonatal and adult) and inhibition of ecto-5'-nucleotidase. (unboundmedicine.com)
  • This release of adenosine and cyclic AMP was reduced after i.t. pretreatment with 5,7-dihydroxytryptamine (100 micrograms) but not 6-hydroxydopamine (100 micrograms). (islandscholar.ca)
  • A 90% loss of norepinephrine transporters (NET) produced by 6-hydroxydopamine pretreatment, resulted in a two-fold reduction in V max and a 30% decrease in K T in the dentate gyrus, but no change in kinetic parameters in the CA3 region. (uthscsa.edu)
  • Pretreatment with 5,7-dihydroxytryptamine that resulted in a 90% reduction in 5-HTT density, modestly reduced V max in dentate gyrus but not in CA3. (uthscsa.edu)
  • 5,7-DHT produced equivalent, dose-related depletion of hippocampal norepinephrine in both age groups. (elsevier.com)
  • We also found that the noradrenergic-depleting effects of 5,7-DHT were blocked by the non-selective MAO inhibitor pargyline (50mg/kg, i.p.), whilethe selective MAO B inhibitor deprenyl (10 mg/kg, i.p.) failed to prevent this depletion. (elsevier.com)
  • Intracerebroventricular pre-treatment (21 to 28 days earlier) with 5,7-dihydroxytryptamine (5,7-DHT, 150μg) or 6-hydroxydopamine (6-OHDA, 300μg) was used to examine the impact of 5-HT or dopamine depletion on mephedrone-induced changes in temperature and activity. (worktribe.com)
  • Mephedrone-induced hyperactivity was attenuated by 5-HT depletion and 5-HT1B receptor antagonism, whereas the hypothermia was completely abolished by 5-HT depletion and lessened by 5-HT1A receptor antagonism. (worktribe.com)
  • Firstly, chronic depletion of serotonin with the pharmacological agent 5,7-dihydroxytryptamine attenuates neurogenesis [3,14]. (livingseas.org)
  • The drug did not appear to affect the concentration of 5-HIAA except in the cerebellum where there was a considerable depletion. (bvsalud.org)
  • A final study examined the influence of i.p. pre-treatment (-30min) with the 5-HT1A receptor antagonist WAY-100635 (0.5mg/kg), 5-HT1B receptor antagonist GR 127935 (3mg/kg) or the 5-HT7 receptor antagonist SB-258719 (10mg/kg) on mephedrone-induced changes in locomotor activity and rectal temperature. (worktribe.com)
  • the P. clarkii 5-HT2-specific antagonist methiothepin mesylate salt (MMS) suppresses neurogenesis in this region. (livingseas.org)
  • By contrast, the NET antagonist, desipramine, significantly inhibited 5-HT clearance when extracellular concentrations of 5-HT were greater than the K T value. (uthscsa.edu)
  • The present study investigated the neurochemical effects of the selective 5-HT(6) receptor antagonist SB-271046 in the rat medial prefrontal cortex (mPFC). (meta.org)
  • Regulation of synapse density by 5-HT-2A receptor agonist and antagonist in the spinal cord of embryo' Neuroscience Letters. (nii.ac.jp)
  • Pindobind (0.5 μ g i.t.), a 5-HT 1A antagonist, notably attenuated EAA at different frequencies. (hindawi.com)
  • We determined the dose-related serotonin and norepinephrine-depleting effects of the selective neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), in C57BL/6 mice of 2 different ages. (elsevier.com)
  • Norepinephrine and serotonin in the hippocampus were assayed 1 week after the intracerebroventricular (i.c.v.) administration of 5,7-DHT. (elsevier.com)
  • Brain norepinephrine and dopamine concentration were not affected by 5-HTP in either group of animals. (elsevier.com)
  • The effect of SB-271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. (meta.org)
  • In the presence of 5,6-dihydroxytryptamine accumulation of serotonin, dopamine and noradrenaline is inhibited to a similar degree. (elsevier.com)
  • Mephedrone caused rapid-onset hyperactivity, hypothermia (attenuated on repeat dosing), and increased striatal dopamine and 5-HT release following each injection. (worktribe.com)
  • Neurotransmitters such as acetylcholine, dopamine and serotonin (5-HT), diverse neuropeptides such as substance P and calcitonin gene-related peptide have been identified (3,6,7). (scielo.br)
  • Among invertebrates, the most common catecholamine is dopamine, while adrenaline and noradrenaline are rare (6). (scielo.br)
  • In a pharmacological review of rhythmic behaviors such as locomotion or breathing, the modulatory role of 5-HT is noteworthy in the control of locomotion (8,10) and feeding (11-13), while dopamine has been reported to play a role in breathing (14). (scielo.br)
  • We used quantitative autoradiography to measure the contribution of the 5-hydroxytryptamine (5-HT, serotonin) innervation of rat telencephalon to the synthesis of dopamine (DA) from exogenous L-DOPA. (semanticscholar.org)
  • 5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. (wikipedia.org)
  • 5 Jülich-Aachen Research Alliance-Translational Brain Medicine. (sciencemag.org)
  • [ 4 ] [ 5 ] The O - methylated analogue of αMS, 5-MeO-αMT , also readily enters the brain and may be used for this purpose as well. (worldheritage.org)
  • report their results March 6 in the journal Brain Research. (antidepressantsfacts.com)
  • MDMA and another drug, 5,7-dihydroxytryptamine (5,7-DHT), were used as controls because both drugs push serotonin out of the brain cells. (antidepressantsfacts.com)
  • These data show for the first time in the whole animal that 5-HT clearance in brain is regionally distinct with regard to rate and affinity. (uthscsa.edu)
  • In animal studies, central serotonergic system impairment with intrathecal and intracerebroventricular 5,7-DHT administration and assessment of brain serotonin levels were the most commonly used methods. (turkjps.org)
  • These data suggest that i.c.v. morphine activates descending serotonergic pathways to release purines from the spinal cord, and that such release is secondary to release of 5-hydroxytryptamine. (islandscholar.ca)
  • The 5-HTP-induced changes include elevation of serum prolactin decrease in operant responding, and the magnitude of the "serotonin behavioral syndrome" observed after 5-HTP administration. (elsevier.com)
  • 6-Hydroxydopamine treatment did not cause significant alteration in the prolactin response. (elsevier.com)
  • In previous studies, it was shown that 5-HT release from the spinal dorsal horn was significantly stimulated by somatostatin and substance P in vitro , but not by neurotensin or met-enkephalin [ 11 ]. (hindawi.com)
  • Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) contents were quantified and the level of 5-HIAA in the caudal dorsal raphe nucleus (DRN) was increased under basal conditions in CRFR2-null mice, indicating increased 5-HT turnover. (biomedcentral.com)
  • 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices. (univoak.eu)
  • The lesions reduced the concentration of 5-HT (-90%) and the accumulation (-80%) as well as the evoked release (-90%) of [3H]5-HT. (univoak.eu)
  • were inhibited in the ipsilateral lamina I/II by 5-HT 1/2B/2C (methysergide), 5-HT 2A (ketanserin) or 5-HT 1/2A/2C/5/6/7 (methiothepin) receptors antagonists, in the ipsilateral lamina V by methysergide or methiothepin, in the contralateral lamina V by all the serotonergic antagonists and in the lamina X by LY 278,584, ketanserin or methiothepin. (biomedcentral.com)
  • The serotonin concentration in brains of 5,7-DHT-treated animals reached maximum earlier and remained elevated longer than that of controls following administration of 5-HTP. (elsevier.com)
  • They were labeled to essentially the same brightness and remained so despite variations in the concentration at which 5,7-DHT had been applied or the duration of its application. (jneurosci.org)
  • One of the nonopioid mechanisms of tramadol consists in the enhancement of the extraneuronal concentration of 5-HT by inhibiting the 5-HT transporter. (asahq.org)
  • On the other hand, the 5-hydroxytryptamine concentration in the hypothalamus from prenatally stressed offspring in adulthood was observed to be higher than controls, in contrast of unaltered serotonin metabolite, 5-hydroxyindoleacetic acid. (nii.ac.jp)
  • Cairncross KD, Cox B, Forster C, Wren A. The ability of local injection of 6-OHDA, 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat. (thefullwiki.org)
  • all previously identified cell types exhibiting serotonin-like immunoreactivity (sli) were labeled by intravitreal injection of 5,7-dihydroxytryptamine (5,7-dht). (liverpool.ac.uk)
  • The lesion-induced reduction of the 5-HT1B autoreceptor-mediated inhibition of evoked 5-HT release may be an adaptation enhancing serotonergic transmission in the (few) remaining terminals. (univoak.eu)
  • These findings suggest that stimulation of central 5-HT release and/or inhibition of 5-HT reuptake play a pivotal role in both the hyperlocomotor and hypothermic effects of mephedrone, which are mediated in part via 5-HT1B and 5-HT1A receptors. (worktribe.com)
  • Not only has decreased prostaglandin production via cyclooxygenase (COX) enzyme inhibition (especially COX-2, and a central splice variant of COX-1, which is COX-3) been proposed as the primary mechanism of analgesic action, 1,2,3 but also the contribution of cannabinoidergic 4 and opioidergic 5 systems has been shown. (turkjps.org)
  • 1999 Nov-Dec;49(6):990-8. (nih.gov)
  • abstract = "Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. (elsevier.com)
  • 5-Fluoro-αMT has been found to act as a potent and selective MAO-A inhibitor , [ 1 ] [ 2 ] and also as a 5HT 2A receptor agonist. (gutenberg.org)
  • In addition, the modulatory role of 5-HT in aversive behavior (10,15) has also been documented (16). (scielo.br)
  • History The monoamine neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) can be discovered in the anxious systems of all microorganisms and can be known to impact varied physical, cognitive and behavioral functions [1]. (livingseas.org)
  • In arthropods, it is certainly forecasted that at least 18 monoamine receptors can be found [19], and in crustacean types serotonin receptors accounts for 5 or even more of these [20-22]. (livingseas.org)
  • Parallel with the moderate decrease of the serotonin content of the average length of the active periods of mussels significantly decreases, which is probably the consequence of the effect of 5,6-dihydroxytrptamine on the central and peripheral serotonergic mechanism. (elsevier.com)
  • These latter results suggest that it is the A form of MAO that plays an important role in the mechanism of 5,7-DHT-induced noradrenergic toxicy. (elsevier.com)
  • The mechanism that produces the hallucinogenic and entheogenic effects of 5-MeO-DiPT is thought to result primarily from 5-HT 2A receptor agonism, although additional mechanisms of action such as MAOI may be involved also. (worldheritage.org)
  • These data indicate that the mechanism of EAA involves opioid receptors, and the serotonergic system, particularly, μ -, δ -opioid and 5-HT 1A , 5-HT 3 receptors and it is also dependent on the EAc frequency. (hindawi.com)
  • 5 edition of Neuroactive Drug Spinal Cord found in the catalog. (poldasulteng.com)
  • Effects of milnacipran, a 5-HT and noradrenaline reuptake inhibitor, on C-fibre-evoked field potentials in spinal long-term potentiation and neuropathic pain. (semanticscholar.org)
  • [ 4 ] [ 5 ] As a result, αMTP acts as an orally bioavailable false or substitute neurotransmitter for serotonin, and has been suggested as a therapeutic agent in the treatment of disorders where serotonin is deficient. (worldheritage.org)
  • 5-MeO-DiPT is orally active, and dosages between 6-20 mg are commonly reported. (worldheritage.org)
  • These data indicate that hippocampal uptake of 5-HT may be mediated by two processes, one with high affinity but low capacity (i.e. the 5-HTT) and the other with low affinity but a high capacity (i.e. the NET). (uthscsa.edu)
  • Experiments in which 5,7-DHT was applied to retinas incubated in vitro gave identical results. (jneurosci.org)
  • 5-HT1A receptors were quantified by in vitro binding autoradiography. (biomedcentral.com)
  • "5-Carboxamidotryptamin-Derivate als Liganden für 5-HT 7 - und 5-HT 2A -Rezeptoren: Synthese und In-vitro-Pharmakologie" (in German). (wikipedia.org)
  • 5-APB , 5-MAPB , 6-APB and other substituted benzofurans , MDAI , MDMA ). (wikipedia.org)
  • SB-271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5-HT neurotransmission. (meta.org)
  • Serotonin (5-HT) is a key neurotransmitter in the control of mood. (biomedcentral.com)
  • Apparent affinity (K T ) of the serotonin transporter (5-HTT) was similar in DRN and CA3 but greater in dentate gyrus and corpus callosum. (uthscsa.edu)
  • Some studies have shown that the blockade of 5-HT2 or 5-HT3 receptors reduce the antinociceptive effect of systemic tramadol. (asahq.org)
  • The facilitated release of acetylcholine is probably caused by a reduced serotonergic tone on the inhibitory 5-HT1B heteroreceptors of the cholinergic terminals. (univoak.eu)
  • Animal studies on 5-Bromo-DMT showed that it produces effects suggestive of sedative and antidepressant activity and caused significant reduction of locomotor activity in the rodent FST model. (wikipedia.org)
  • 5,6-dihydroxytryptamine injected into the foot muscle of Anodonta cygnea results in a 30% decrease in the serotonin level, but does not significantly influence the catecholamine content of the ganglia. (elsevier.com)
  • 5,7-Dihydroxytryptamine (100 μ g i.t.) significantly inhibited EAA at different frequencies on the 7th day after EAc. (hindawi.com)
  • significantly more depleted than all known industrially produced organochlorine compounds (delta Cl-37 = -7 to +6 parts per thousand). (diva-portal.org)
  • Therefore, most oxy-cholesterols hydroxy-5-cholestenonic acid. (pdfdrug.com)
  • 2-aminomethyl-5-hydroxy-4h-pyran-4-one), a compound which shares some structural features with gamma-aminobutyric acid (gaba) and muscimol, has been examined in a variety of test systems for gabamimetic activity. (liverpool.ac.uk)
  • Following 5-HT receptor agonist challenge, LCMRglu responses indicated that 5-HT 1A receptor responses in the DRN were attenuated in CRFR2-null mice. (biomedcentral.com)
  • However, postsynaptic 5-HT receptor responses in forebrain regions were intact. (biomedcentral.com)
  • Somewhat unexpectedly, older mice were found to be less susceptible to the serotonin-depleting effects of 5,7-DHT. (elsevier.com)
  • They also decreased the inhibitory effects of CP-93,129 on the evoked release of [3H]5-HT. (univoak.eu)
  • 6-10 Thus, it has been suggested that tramadol is a prodrug, and M1 is important for the analgesic effects of tramadol. (asahq.org)
  • These effects of NTP were reversed by K252a, and 5,7-DHT. (springer.com)
  • β -Endorphin predominantly synthetized in the arcuate nucleus of the hypothalamus has major analgesic effects via μ -, κ -opioid receptors in the periaqueductal gray region [ 5 ]. (hindawi.com)
  • Syntheses and antitumor activities of compounds related to 1-(tetrahydro-2-furanyl)-5-fluorouracil metabolites. (nii.ac.jp)
  • Human/ D. melanogaster SERT chimera studies implicated the first two SERT transmembrane domains (TMDs) in the potency of the indole nitrogen-substituted compounds N -isopropyltryptamine (NIT), 5-methoxy- N -isopropyltryptamine (5-MNIT), and the 7-substituted compound 7-benzyloxytryptamine (7BT). (aspetjournals.org)