Methylenetetrahydrofolate Reductase (NADPH2)
5,10-Methylenetetrahydrofolate Reductase (FADH2)
Oxidoreductases Acting on CH-NH Group Donors
Methylenetetrahydrofolate Dehydrogenase (NADP)
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Folic Acid
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Genotype
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Hyperhomocysteinemia
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 µmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
Vitamin B 12
A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.
Ferredoxin-NADP Reductase
Factor V
Genetic Predisposition to Disease
Cystathionine beta-Synthase
Thymidylate Synthase
Thrombophilia
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Folic Acid Deficiency
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
Gene Frequency
Glycine Hydroxymethyltransferase
Riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
Flavin-Adenine Dinucleotide
Homocystinuria
Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
Prothrombin
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Alleles
Polymorphism, Single Nucleotide
Risk Factors
Formate-Tetrahydrofolate Ligase
Macedonia (Republic)
Formerly a constituent republic of Yugoslavia, comprising the Yugoslav section of the region of Macedonia. It was made a constituent republic in the 1946 constitution. It became independent on 8 February 1994 and was recognized as The Former Yugoslav Republic of Macedonia by the United States Board on Geographic Names 16 February 1994.
Point Mutation
S-Adenosylmethionine
Mutation
Vitamin B 6
VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Methenyltetrahydrofolate Cyclohydrolase
Odds Ratio
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Neural Tube Defects
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
Betaine
A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
FMN Reductase
Reduced Folate Carrier Protein
NADP
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Asian Continental Ancestry Group
Spinal Dysraphism
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)
Methotrexate
Hydroxymethylglutaryl CoA Reductases
Polymorphism, Restriction Fragment Length
Amino Acid Metabolism, Inborn Errors
Transcobalamins
Pyridoxine
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Dietary Supplements
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Alcohol Oxidoreductases
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Colorectal Neoplasms
Fluorodeoxyuridylate
Cytochrome-B(5) Reductase
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Nitrite Reductases
Heterozygote
Deoxyribodipyrimidine Photo-Lyase
DNA Methylation
Genetic Association Studies
Glutathione Reductase
Thioredoxin-Disulfide Reductase
Tetrahydrofolate Dehydrogenase
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Confidence Intervals
NADPH-Ferrihemoprotein Reductase
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Pharmacogenetics
Pteroylpolyglutamic Acids
Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.
Risk
Base Sequence
Pregnancy
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Oxidoreductases Acting on CH-CH Group Donors
Vascular Diseases
Dihydropteridine Reductase
Enzyme Stability
Haplotypes
Flavins
Reference Values
S-Adenosylhomocysteine
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Riboflavin
Glutathione reductase is a nicotinamide adenine dinucleotide phosphate (NADPH) and FAD-dependent enzyme, and the major ... The measurement of the activity coefficient of erythrocyte glutathione reductase (EGR) is the preferred method for assessing ... by glutathione reductase is FAD dependent For the molecular mechanism of action see main articles flavin mononucleotide (FMN) ... Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3, 4-dihydroxy-2-butanone 4-phosphate obtained from ...
MTRR (gene)
"Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association ... FADH2). Flavin mononucleotide binding domain interacts with a coenzyme of flavoprotein oxidoreductase enzymes, FMN. ... It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Methionine synthase reductase (MTRR) ... Methylenetetrahydrofolate reductase act to further the extent of DNA damage. Hypomethylation due to impaired methylation up ...
List of EC numbers (EC 2)
FADH2-oxidizing) EC 2.1.1.75: apigenin 4'-O-methyltransferase EC 2.1.1.76: quercetin 3-O-methyltransferase EC 2.1.1.77: protein ... NAD+-dinitrogen-reductase ADP-D-ribosyltransferase EC 2.4.2.38: glycoprotein 2-b-D-xylosyltransferase EC 2.4.2.39: xyloglucan 6 ... methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase ( ... reductase kinase) kinase EC 2.7.11.4: (3-methyl-2-oxobutanoate ... hydroxymethylglutaryl-CoA reductase (NADPH)) kinase EC 2.7.11.32: (pyruvate, phosphate dikinase) kinase EC 2.7.11.33: (pyruvate ...
metF - 5,10-methylenetetrahydrofolate reductase - Escherichia coli (strain K12) - metF gene & protein
Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert ... TIGR00676. fadh2. 1 hit. ,p>This section displays by default the canonical protein sequence and upon request all isoforms ... methylenetetrahydrofolate reductase (NAD(P)H) activity Source: EcoCyc ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a ... Belongs to the methylenetetrahydrofolate reductase family.Curated. Phylogenomic databases. evolutionary genealogy of genes: Non ...
KEGG ENZYME: 1.7.99.5
MEDLINE - Resultado p gina 1
FADH2)); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.39 (homoserine kinase); K3Z4F929H6 (Lysine); ... 10, 219-225] and point to a key role for the Tyr-442 (TMADH) and Arg-alpha237 (ETF) residue pair in transiently stabilizing ... A single-base substitution was identified in this auxotroph in codon-329 of the open reading frame of metF, encoding 5,10- ... methylene-tetra-hydrofolate reductase. We constructed a metF disruptant mutant carrying both dapA24 and lysE24, and confirmed ...
Riboflavin - Wikipedia
Glutathione reductase is a nicotinamide adenine dinucleotide phosphate (NADPH) and FAD-dependent enzyme, and the major ... The measurement of the activity coefficient of erythrocyte glutathione reductase (EGR) is the preferred method for assessing ... by glutathione reductase is FAD dependent For the molecular mechanism of action see main articles flavin mononucleotide (FMN) ... Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3, 4-dihydroxy-2-butanone 4-phosphate obtained from ...
Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with...
FADH2) / genetics* Actions. * Search in PubMed * Search in MeSH ... The C677T mutation in methylenetetrahydrofolate reductase gene ... Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid ... 2003 Sep-2004 Dec;33(5-6):342-4. doi: 10.1159/000083825. Pathophysiol Haemost Thromb. 2003. PMID: 15692240 Review. ... Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with ...
MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers - PubMed
Two common polymorphisms (SNPs), C677T and A1298C, in the 5, … ... Meta-analysis of Methylenetetrahydrofolate reductase maternal ... FADH2) / genetics* Actions. * Search in PubMed * Search in MeSH ... Am J Med Genet A. 2004 May 15;127A(1):5-10 - PubMed ... Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down syndrome in Jordan. Sadiq ... Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity. Lim KK, Teo HY, ...
DeCS
FADH2) - Preferred Concept UI. M0076715. Scope note. An FAD-dependent oxidoreductase found primarily in BACTERIA. It is ... Plastoquinol Plastocyanin Reductase [D08.811.682.771] Plastoquinol Plastocyanin Reductase * Ribonucleotide Reductases [D08.811. ... FADH2) was indexed under OXIDOREDUCTASES 1987-2003, under ALCOHOL OXIDOREDUCTASES 1974-1986, under TETRAHYDROFOLATES 1974-1982 ... It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed ...
DM42 1555 protein (Burkholderia cepacia) - STRING interaction network
Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: A systematic review on content and adherence...
FADH2), abacavir, acenocoumarol, alpha adducin, aminoglycoside, clozapine, cytochrome P450 2C19, cytochrome P450 2C9, ... hydroxymethylglutaryl coenzyme A reductase inhibitor, phenprocoumon, reduced nicotinamide adenine dinucleotide (phosphate) ... keywords = "Cost effectiveness, Genetic Screening, Pharmacogenomics, 5,10 methylenetetrahydrofolate reductase ( ...
Loss of MAOA and MAOB interacting with Neocate - lookformedical.com
Associations between MTHFR polymorphisms and the risk of potentially malignant oral disorders<...
FADH2), 9028-69-7; methylenetetrahydrofolate reductase (NADPH2), 71822-25-8; Methylenetetrahydrofolate Reductase (NADPH2) 參考文獻 ... FADH2), 9028-69-7; methylenetetrahydrofolate reductase (NADPH2), 71822-25-8; Methylenetetrahydrofolate Reductase (NADPH2) 參考文獻 ... FADH2), genomic DNA, methylenetetrahydrofolate reductase (NADPH2), adult, alcohol consumption, allele, Article, carcinogenesis ... 522-528; Guo, S., Jiang, X., Chen, X., Chen, L., Li, X., Jia, Y., The protective effect of methylenetetrahydrofolate reductase ...
Urate Oxidase | Harvard Catalyst Profiles | Harvard Catalyst
Alcohol Oxidoreductases | Harvard Catalyst Profiles | Harvard Catalyst
NAVER 학술정보 >...
Superoxide Dismutase | Profiles RNS
TNO Repository search for: creator:'Jakobs, C.'
Biology · Analytical research · B vitamins · Folate · Mass spectrometry · Methylenetetrahydrofolate reductase (MTHFR) · Red ... Methods: Ten healthy men and nine healthy postmenopausal women (aged 45-65 years) participated in a randomized, diet-controlled ... FADH2) · cyanocobalamin · folic acid · homocysteine · pyridoxine · riboflavin · s adenosylhomocysteine · s adenosylmethionine ... So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate ...
Methionine Sulfoxide Reductases | Profiles RNS
Below are the most recent publications written about "Methionine Sulfoxide Reductases" by people in Profiles over the past ten ... Peptide-Methionine (S)-S-oxide Reductase*Peptide-Methionine (S)-S-oxide Reductase ... Peptide-Methionine (R)-S-oxide Reductase*Peptide-Methionine (R)-S-oxide Reductase ... Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + ...
Search Articles | University of Toronto Libraries
INACTIVATION , S-ADENOSYLMETHIONINE , MEDICINE, GENERAL & INTERNAL , HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE , RISK FACTOR , ... FADH2) , Oxidoreductases - deficiency , Oxidoreductases - metabolism , RNA - analysis , Oxidoreductases - genetics , Cells, ... Methylenetetrahydrofolate Reductase (NADPH2) , Homocysteine - metabolism , Anesthetics, Inhalation - adverse effects , 5- ... 5. Full Text A high-resolution map of segmental DNA copy number variation in the mouse genome ...
DeCS 2008 - May 16, 2008 version
Reductase (FADH2). 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) ... 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo(a)pyrene use 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
Search Articles | University of Toronto Libraries
INACTIVATION , S-ADENOSYLMETHIONINE , MEDICINE, GENERAL & INTERNAL , HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE , RISK FACTOR , ... FADH2) , Oxidoreductases - deficiency , Oxidoreductases - metabolism , RNA - analysis , Oxidoreductases - genetics , Cells, ... Methylenetetrahydrofolate Reductase (NADPH2) , Homocysteine - metabolism , Anesthetics, Inhalation - adverse effects , 5- ... 10. Full Text High-Resolution Mapping of DNA Copy Alterations in Human Chromosome 22 Using High-Density Tiling Oligonucleotide ...
Oxygenases | Profiles RNS
MTRR (gene) - Wikipedia
"Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association ... FADH2). Flavin mononucleotide binding domain interacts with a coenzyme of flavoprotein oxidoreductase enzymes, FMN. ... It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Methionine synthase reductase (MTRR) ... Methylenetetrahydrofolate reductase act to further the extent of DNA damage. Hypomethylation due to impaired methylation up ...
Arsenate Reductases | Profiles RNS
"Arsenate Reductases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Arsenate Reductases" by people in this website by year, and ... Below are the most recent publications written about "Arsenate Reductases" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Arsenate Reductases". ...
MTHFR4
- To investigate the association between concentrations of plasma homocysteine and folic acid, 5,10-methylenetetrahydrofolate reductase (MTHFR) C667T mutation and venous thromboembolism (VTE) and to analyze the effect of MTHFR C667T mutation on concentrations of plasma homocysteine and folic acid. (cdc.gov)
- Two common polymorphisms (SNPs), C677T and A1298C, in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene involved in folate metabolism, are known to lower the activity of this enzyme. (cdc.gov)
- abstract = "Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs). (elsevier.com)
- MTHFR (Methylenetetrahydrofolate Reductase) is a Protein Coding gene. (genecards.org)
NADPH3
- Glutathione reductase is a nicotinamide adenine dinucleotide phosphate (NADPH) and FAD-dependent enzyme, and the major flavoprotein in erythrocytes. (wikipedia.org)
- MTR reactivation can also be NADPH dependent involving two redox proteins, soluble cytochrome b5 and reductase 1. (wikipedia.org)
- Enhanced glucose utilization also increases the metabolic flux through pentose phosphate pathway (PPP) ( 5 ), which provides anabolic building blocks for nucleotide synthesis and NADPH for anti-oxidant defenses, whereas glycolytic intermediates are used for the biosynthesis of amino acids ( 4 , 6 - 8 ). (frontiersin.org)
Gene8
- The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease. (cdc.gov)
- Methionine synthase reductase also known as MSR is an enzyme that in humans is encoded by the MTRR gene. (wikipedia.org)
- The Methionine Synthase Reductase (MTRR) gene primarily acts in the reductive regeneration of cob(I)alamin (vitamin B12). (wikipedia.org)
- 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase MSR [Methionine Synthase]- Cobalamin Methyltransferase (Cob(II)Alamin Reducing) Methionine Synthase Reductase, Mitochondrial EC 1.16.1.8 CblE The gene was mapped to human chromosome 5. (wikipedia.org)
- Gene specific primer pairs resulted in PCR amplification of a product matched by size to a hybrid-mapping panel containing only chromosome 5 as its human genetic material. (wikipedia.org)
- The MTRR gene is associated with a family of electron transferases known as the Ferredoxin-NADP(+) reductase (FNR) family. (wikipedia.org)
- The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. (genecards.org)
- Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. (genecards.org)
NADH1
- Under homeostatic conditions, Nrf2 affects the mitochondrial membrane potential, fatty acid oxidation, availability of substrates (NADH and FADH2/succinate) for respiration, and ATP synthesis. (wellnessdoctorrx.com)
Cytochrome3
- They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99). (harvard.edu)
- Discussion Points==== * GO: 0006118 electron transport and children * GO:0006133 : 5,10-methylenetetrahydrofolate oxidation * GO:0019646 : aerobic electron transport * GO:0019645 : anaerobic electron transport * GO:0000044 : ascorbate stabilization * GO:0042773 : ATP synthesis coupled electron transport * GO:0010478 : chlororespiration * GO:0006127 : glycerophosphate shuttle * GO:0043490 : malate-aspartate shuttle * GO:0006123 : mitochondrial electron transport, cytochrome c to oxygen (ok? (geneontology.org)
- Flavoprotein pyridine nucleotide cytochrome reductases, including FAD catalyse the interchange of reducing equivalents (H+ or electrons). (wikipedia.org)
Homocysteine3
- Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. (uniprot.org)
- Methionine synthase reductase (MTRR) is primarily involved in the reductive methylation of homocysteine to methionine, utilizing methylcob(I)alamin as an intermediate methyl carrier. (wikipedia.org)
- The enzyme bound cob(I)alamin cofactor of the MTR enzyme functions as a methyl carrier between 5-MTHF and homocysteine. (wikipedia.org)
Folate1
- Circulating blood folate (5-methyl tetrahydrofolate, 5-MTHF) donates methyl groups to MTR to be utilized in cellular methylation. (wikipedia.org)
Methionine5
- Methionine Sulfoxide Reductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
- Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O. (uams.edu)
- This graph shows the total number of publications written about "Methionine Sulfoxide Reductases" by people in UAMS Profiles by year, and whether "Methionine Sulfoxide Reductases" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "Methionine Sulfoxide Reductases" by people in Profiles over the past ten years. (uams.edu)
- Methionine synthase reductase regenerates a functional methionine synthase via reductive methylation. (wikipedia.org)
Transferases1
- It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. (wikipedia.org)
Reduction2
- It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. (bvsalud.org)
- Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice. (harvard.edu)
Entry1
- Deleted entry: 5,10-methylenetetrahydrofolate reductase (FADH2). (genome.jp)
Profiles1
- Below are the most recent publications written about "Oxygenases" by people in Profiles over the past ten years. (uams.edu)
Activity1
- The measurement of the activity coefficient of erythrocyte glutathione reductase (EGR) is the preferred method for assessing riboflavin status. (wikipedia.org)
Years1
- Methods: Ten healthy men and nine healthy postmenopausal women (aged 45-65 years) participated in a randomized, diet-controlled, crossover trial. (tudelft.nl)
Plasma1
- Changes over time of plasma vitamin B6 (μg/liter) were similar to changes in plasma pyridoxal-5-phosphate (p = 0.10). (tudelft.nl)