4-Nitroquinoline-1-oxide: A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.Nitroquinolines: Quinolines substituted in any position by one or more nitro groups.Tongue Neoplasms: Tumors or cancer of the TONGUE.4-Hydroxyaminoquinoline-1-oxide: A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.Tongue: A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.Hesperidin: A flavanone glycoside found in CITRUS fruit peels.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Pronase: A proteolytic enzyme obtained from Streptomyces griseus.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Aminoquinolines: Quinolines substituted in any position by one or more amino groups.Mouth Neoplasms: Tumors or cancer of the MOUTH.QuinolinesPapilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)PolyaminesAnticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Rats, Inbred F344Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Nitric Oxide Synthase Type I: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Propiolactone: Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic.Lysogeny: The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.Salmonella Phages: Viruses whose host is Salmonella. A frequently encountered Salmonella phage is BACTERIOPHAGE P22.Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Pyrimidine Dimers: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.IllinoisFrameshift Mutation: A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.United States Environmental Protection Agency: An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Eicosapentaenoic Acid: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.Docosahexaenoic Acids: C22-unsaturated fatty acids found predominantly in FISH OILS.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide. (1/242)

The yeast gene SNQ2, which encodes a multidrug resistance ABC superfamily protein, is required for resistance to the mutagen 4-nitroquinoline N-oxide (4-NQO). The expression of the SNQ2 gene is under the control of a regulatory network that involves the transcription factor Yrr1p, as well as Pdr1p/Pdr3p (Cui et al., Mol. Microbiol., 29, 1307-1315 (1998)). By 5'-deletion analysis of the promoter by using SNQ2-lacZ fusion constructs, four regions: -745 to -639 (region I), -639 to -578 (region II), -548 to -533 (region III) and -533 to -485 (region IV) were found to be important for SNQ2 expression. Genetic analysis suggested that the site in region IV was responsible for the Yrr1p-mediated SNQ2 expression. A consensus motif known for the binding of Pdr1p/Pdr3p (PDRE) was not found in region IV.  (+info)

Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine. (2/242)

The effects of three widely differing chemical carcinogens, 4-nitroquinoline 1-oxide, Adriamycin, and ethyleneimine, on DNA replication were studied by pulse labeling of DNA with [3H]thymidine and sedimentation analysis with alkaline sucrose gradients. At doses that reduced the rate of DNA synthesis to 30 to 60% of control values, only ethyleneimine produced damage that resulted in lower molecular weights of parental DNA. All three chemicals inhibited replicon initiation, but to differing extents. Inhibition of replicon initiation was the first clearly identified effect of 4-nitroquinoline 1-oxide and was the main cause of inhibition of DNA synthesis. Ethyleneimine caused severe inhibition of replicon initiation, but blocks to chain elongation also contributed significantly to the inhibition of overall DNA synthesis. Adriamycin affected replicon initiation to a small but significant extent; the primary cause of inhibition of DNA synthesis by this drug was a slowing of the rate of chain elongation. These results indicate that inhibition of replicon initiation is an important mechanism for the action of DNA-damaging agents in mammalian cells and strengthen the concept that control of DNA replication depends on the structural integrity of a chromosomal subunit that consists of several replicons.  (+info)

Inverse correlation between p53 protein levels and DNA repair efficiency in human fibroblast strains treated with 4-nitroquinoline 1-oxide: evidence that lesions other than DNA strand breaks trigger the p53 response. (3/242)

Ionizing radiation-induced stabilization and the resultant transient accumulation of the p53 tumor suppressor protein is impaired in cells from ataxia telangiectasia (AT) patients, indicating a key role for ATM, the gene mutated in AT, upstream in the radiation-responsive p53 signaling pathway. Activation of this pathway is generally assumed to be triggered by DNA strand breaks produced directly following genotoxic stress or indirectly during excision repair of DNA lesions. The aim of this study was to identify the triggering signal for induction of p53 in diploid human dermal fibroblasts treated with 4-nitroquinoline 1-oxide (4NQO), a model environmental carcinogen that produces both DNA strand breaks (like ionizing radiation) and alkali-stable bulky DNA lesions (like UV light). 4NQO treatment of fibroblasts cultured from normal and AT donors and those from patients with the UV-hypersensitivity disorder xeroderma pigmentosum (XP, complementation groups A, E and G) resulted in up-regulation of p53 protein. In normal fibroblasts, there was no temporal relationship between the incidence of DNA strand breaks and levels of p53 protein; >90% of strand breaks and alkali-labile sites were repaired over 2 h following treatment with 1 microM 4NQO, whereas approximately 3 h of post-treatment incubation was required to demonstrate a significant rise in p53 protein. In contrast, exposure of normal fibroblasts to gamma-rays resulted in a rapid up-regulation of p53 and the level peaked at 2 h post-irradiation. XP cells with a severe deficiency in the nucleotide excision repair pathway showed abnormally high levels of p53 protein in response to 4NQO treatment, indicating that lesions other than incision-associated DNA strand breaks trigger p53 up-regulation. We observed a consistent, inverse correlation between the ability of the various fibroblast cultures to induce p53 following 4NQO treatment and their DNA repair efficiencies. Treatment with 0.12 microM 4NQO, for example, caused a >2-fold up-regulation of p53 in excision repair-deficient (AT, XPA and XPG) strains without eliciting any effect on p53 levels in repair-proficient (normal and XPE) strains. We conclude that up-regulation of p53 by 4NQO is mediated solely by an ATM-independent mechanism and that the p53 response is primarily triggered by persistent alkali-stable 4NQO-DNA adducts.  (+info)

Development of a new bioluminescent mutagenicity assay based on the Ames test. (4/242)

A newly developed rapid mutagenicity assay based on the adenosine triphosphate (ATP)-bioluminescence technique and the Ames test is described. Salmonella typhimurium strains TA98 and TA100 were exposed in an appropriate liquid medium to the direct mutagens 4-nitroquinoline-N-oxide and methyl methanesulphonate, respectively, and to the indirect mutagen 2-aminoanthracene. Both auxotrophic and prototrophic growth were monitored throughout the incubation period as variations in the intracellular ATP levels by means of the luciferin-luciferase assay. After 9-12 h of incubation a dose-response increase in the levels of ATP was readily detected. In order to demonstrate that this increase was due to the growth of revertant bacteria, aliquots from each culture were plated on minimal agar plates. A very good correlation between the changes in ATP levels and the appearance of revertant colonies on the plates was found. Given the rapidity of this method as compared with conventional mutagenicity assays, it has potential for industrial and environmental applications. Other potential applications are also discussed.  (+info)

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. (5/242)

Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which many characteristics of aging are accelerated. A probable role in some aspect of DNA metabolism is suggested by the primary sequence of the WRN gene product. A recombinant His-tagged WRN protein (WRNp) was overproduced in insect cells using the baculovirus system and purified to near homogeneity by several chromatographic steps. This purification scheme removes both nuclease and topoisomerase contaminants that persist following a single Ni(2+)affinity chromatography step and allows for unambiguous interpretation of WRNp enzymatic activities on DNA substrates. Purified WRNp has DNA-dependent ATPase and helicase activities consistent with its homology to the RecQ subfamily of proteins. The protein also binds with higher affinity to single-stranded DNA than to double-stranded DNA. However, WRNp has no higher affinity for various types of DNA damage, including adducts formed during 4NQO treatment, than for undamaged DNA. Our results confirm that WRNp has a role in DNA metabolism, although this role does not appear to be the specific recognition of damage in DNA.  (+info)

Regulation of the ribonucleotide reductase small subunit gene by DNA-damaging agents in Dictyostelium discoideum. (6/242)

In Escherichia coli, yeast and mammalian cells, the genes encoding ribonucleotide reductase, an essential enzyme for de novo DNA synthesis, are up-regulated in response to DNA damaging agents. We have examined the response of the rnrB gene, encoding the small subunit of ribonucleotide reductase in Dictyostelium discoideum, to DNA damaging agents. We show here that the accumulation of rnrB transcript is increased in response to methyl methane sulfonate, 4-nitroquinoline-1-oxide and irradiation with UV-light, but not to the ribonucleotide reductase inhibitor hydroxyurea. This response is rapid, transient and independent of protein synthesis. Moreover, cells from different developmental stages are able to respond to the drug in a similar fashion, regardless of the basal level of expression of the rnrB gene. We have defined the cis -acting elements of the rnrB promoter required for the response to methyl methane sulfonate and 4-nitroquinoline-1-oxide by deletion analysis. Our results indicate that there is one element, named box C, that can confer response to both drugs. Two other boxes, box A and box D, specifically conferred response to methyl methane sulfonate and 4-nitroquinoline-1-oxide, respectively.  (+info)

Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. (7/242)

Rsp5 is an E3 ubiquitin-protein ligase of Saccharomyces cerevisiae that belongs to the hect domain family of E3 proteins. We have previously shown that Rsp5 binds and ubiquitinates the largest subunit of RNA polymerase II, Rpb1, in vitro. We show here that Rpb1 ubiquitination and degradation are induced in vivo by UV irradiation and by the UV-mimetic compound 4-nitroquinoline-1-oxide (4-NQO) and that a functional RSP5 gene product is required for this effect. The 26S proteasome is also required; a mutation of SEN3/RPN2 (sen3-1), which encodes an essential regulatory subunit of the 26S proteasome, partially blocks 4-NQO-induced degradation of Rpb1. These results suggest that Rsp5-mediated ubiquitination and degradation of Rpb1 are components of the response to DNA damage. A human WW domain-containing hect (WW-hect) E3 protein closely related to Rsp5, Rpf1/hNedd4, also binds and ubiquitinates both yeast and human Rpb1 in vitro, suggesting that Rpf1 and/or another WW-hect E3 protein mediates UV-induced degradation of the large subunit of polymerase II in human cells.  (+info)

The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. (8/242)

Cockayne syndrome (CS) is a human genetic disorder characterized by UV sensitivity, developmental abnormalities, and premature aging. Two of the genes involved, CSA and CSB, are required for transcription-coupled repair (TCR), a subpathway of nucleotide excision repair that removes certain lesions rapidly and efficiently from the transcribed strand of active genes. CS proteins have also been implicated in the recovery of transcription after certain types of DNA damage such as those lesions induced by UV light. In this study, site-directed mutations have been introduced to the human CSB gene to investigate the functional significance of the conserved ATPase domain and of a highly acidic region of the protein. The CSB mutant alleles were tested for genetic complementation of UV-sensitive phenotypes in the human CS-B homologue of hamster UV61. In addition, the CSB mutant alleles were tested for their ability to complement the sensitivity of UV61 cells to the carcinogen 4-nitroquinoline-1-oxide (4-NQO), which introduces bulky DNA adducts repaired by global genome repair. Point mutation of a highly conserved glutamic acid residue in ATPase motif II abolished the ability of CSB protein to complement the UV-sensitive phenotypes of survival, RNA synthesis recovery, and gene-specific repair. These data indicate that the integrity of the ATPase domain is critical for CSB function in vivo. Likewise, the CSB ATPase point mutant failed to confer cellular resistance to 4-NQO, suggesting that ATP hydrolysis is required for CSB function in a TCR-independent pathway. On the contrary, a large deletion of the acidic region of CSB protein did not impair the genetic function in the processing of either UV- or 4-NQO-induced DNA damage. Thus the acidic region of CSB is likely to be dispensable for DNA repair, whereas the ATPase domain is essential for CSB function in both TCR-dependent and -independent pathways.  (+info)

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The purpose of this study was to recover DNA sequence information from the HIS4A region of chromosome III in a large number of independently arising, 4-nitroquinoline N-oxide (4NQO)-induced His$\sp+$ revertants of the +1 frameshift mutation his4-38 in Saccharomyces cerevisiae strains XY729 (REV1) and XY760 (rev1-1). These two strains differ in their ability to repair DNA. The REV1 gene is involved in error-prone repair of DNA. The two strains differed in their sensitivity to the lethal effects of 4NQO. To control for this difference both strains were treated with a concentration of 4NQO that led to 37% survival (one lethal hit). To obtain the DNA sequence information, methods for DNA amplification by the polymerase chain reaction (PCR) and subsequent dideoxy sequencing of the double-stranded PCR product were developed. PCR was optimized to generate a high yield of the amplified DNA, and to increase the stringency of the reaction to prevent the formation of artifacts. Double-stranded, dideoxy ...
The promoter of nrdA gene which is related with DNA synthesis was used to construct a DNA damage sensitive biosensor. A recombinant bioluminescent E. coli strain, BBTNrdA, harboring a plasmid with the nrdA promoter fused to the luxCDABE operon, was successfully constructed. Its response to various chemicals including genotoxic chemicals substantiates it as a DNA damage biosensor. In characterization, three different classes of toxicants were used: DNA damaging chemicals, oxidative stress chemicals, and phenolics. BBTNrdA only responded strongly to DNA damaging chemicals, such as nalidixic acid (NDA), mitomycin C (MMC), 1-methyl-1-nitroso-N-methylguanidine (MNNG), and 4-nitroquinoline N-oxide (4-NQO). In contrast, there were no responses from the oxidative stress chemicals and phenolics, except from hydrogen peroxide (H2O2) which is known to cause DNA damage indirectly. Therefore, the results of the study demonstrate that BBTNrdA can be used as a DNA damage biosensor.
Novel and effective targets for cancer therapy and prevention are increasingly important in cancer research, especially for head and neck squamous cell carcinoma (HNSCC), which is one of the most lethal cancers. A potential target for this type of cancer might be sphingosine kinase 1 (SphK1) which phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) because it is a critical regulator of sphingolipid-mediated functions and the SphK1/S1P pathway has been implicated in several important biological functions including inflammation and carcinogenesis. To investigate the potential of SphK1 as a target in head and neck cancer development, we used a 4-nitroquinoline-1-oxide (4-NQO)-induced carcinogenesis tongue model in SphK1 knockout mice. All mice were treated with 4-NQO at 40 μg/ml in drinking water for 14 weeks (untreated water was available thereafter, until the end of the experiment). All animals were sacrificed at 20 weeks and animal tongues were examined. We found that SphK1 ...
3-Nitroquinoline 1-oxide | C9H6N2O3 | CID 81935 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
n-Amyl bromide was tested in an in vitro cytogenetics assay using duplicate cultures of CHO cells. Treatments covering a broad range of doses, separated by narrow intervals, were performed. The test article was dissolved in dimethyl sulphoxide and the highest dose level used was 500 µg/ml. Treatment was performed in the absence of S-9 for 20 hours proir to harvest (20 +0). The test article dose levels for chromosome analysis were selected by evaluating the effect of n-Amyl bromide on cell number. Chromosome aberrations were analysed at three consecutive dose levels. The highest concentration chosen for analysis, 163.8 µg/ml, induced approximately 74 ù reduction in cell number and 58 % mitotic inhibition. Appropriate negative (solvent) control cultures were included in the test system. The proportion of cells with structural aberrations in these cultures fell within the historical solvent control range. 4 -Nitroquinoline-1-oxide was employed as the positive control chemical and cells receiving ...
Animal models for carcinogenesis of the oral cavity are limited, although this disease is often fatal or disfiguring and its incidence in the USA is ~30 000 cases/year. Short-term whole-animal models for this disease should prove valuable in the investigation of factors affecting oral carcinogenesis. In this study we observed that a group of oral carcinogens are clearly mutagenic in the lacZ transgenic mouse oral cavity. The carcinogens 4-nitroquinoline-N-oxide (4-NQO), benzo[a]pyrene (B[a]P), N-nitroso-N-methylurea (NMU), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), nitrosonornicotine (NNN) and 7,12-dimethylbenzanthracene (DMBA) were all mutagenic in a mixture of pooled oral tissues (gingival, buccal, pharyngeal and sublingual) and in the tongue. All agents except DMBA (which was swabbed in the oral cavity) and B[a]P (by gavage) were given in drinking water for 2-4 weeks followed by a 2 week expression period before killing. With one exception, groups of 4-5 female mice were treated. ...
TY - JOUR. T1 - RAD3 gene of Saccharomyces cerevisiae. T2 - Nucleotide sequence of wild-type and mutant alleles, transcript mapping, and aspects of gene regulation. AU - Naumovski, L.. AU - Chu, G.. AU - Berg, P.. AU - Friedberg, E. C.. PY - 1985. Y1 - 1985. N2 - We determined the complete nucleotide sequence of the RAD3 gene of S. cerevisiae. The coding region of the gene contained 2,334 base pairs that could encode a protein with a calculated molecular weight of 89,796. Analysis of RAD3 mRNA by Northern blots and by S1 nuclease mapping indicated that the transcript was approximately 2.5 kilobases and did not contain intervening sequences. Fusions between the RAD3 gene and the lacZ gene of Escherichia coli were constructed and used to demonstrate that the RAD3 gene was not inducible by DNA damage caused by UV radiation or 4-nitroquinoline-1-oxide. Two UV-sensitive chromosomal mutant alleles of RAD3, rad3-1 and rad3-2, were rescued by gap repair of a centromeric plasmid, and their sequences ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire ...
RECOMMENDED: If you have Windows errors then we strongly recommend that you download and run this (Windows) Repair Tool.. Jun 12, 2017. Office VBA Reference Language Reference VBA Class doesnt support Automation (Error 430). Class doesnt support Automation (Error 430).. Microsoft Access 2010 Error Numbers and Descriptions - Microsoft Access 2010 comprehensive list all Error Numbers and Descriptions. how to read/write/update/delete record in tables using vba. - Nov 06, 2008 · how to read/write/update/delete record in tables using vba. Discussion in Microsoft Access VBA Modules started by mike g, Nov 6, 2008.. Post subject: Solution to VBA error 430 Class does not support automation: I got this error when I tried to use a macro which had run great on other machines.. Nov 11, 2008. When I try to create a new object of a class module from this dll I get a Run timer error 430: Class does not support automation or does not.. Problem names and reserved words in Access. This list, from the Database ...
So, I am a complete beginner to VBA. Yet, I have been trying to figure out the code for this using various internet sources. So my idea for this is that i have two sheets of data (say sheet1 and sheet2). Sheet1 is my master list and sheet2 has all the…
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The VBA Programming Language specification defines the implementation-independent and operating-system-independent programming language that must be supported by all conforming VBA implementations.
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I have asked this question in another site, but got no replies, not to speak of a solution. How do I generate an arglist with Excel 97 / VBA ? The code below for an array formula is an example...
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Excel 97 Win98 How can I format the entire range named Cal ? The range is now is B3:H75 I want the first line the default format (bold and font.size=
The modifying effects of two natural products, curcumin and hesperidin, given during the initiation and postinitiation phases of oral carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats and compared with that of β-carotene. At 6 weeks of age, rats were divided into experimental and control groups and fed the diet containing β-carotene, hesperidin, or curcumin at a dose of 0.5 g/kg diet (500 ppm). At 7 weeks of age, all animals except those treated with each test chemical alone and control groups were given 4-NQO (20 ppm) in the drinking water for 8 weeks to induce oral cancer. Seven days after the 4-NQO exposure, groups of animals fed the diets containing test chemicals were switched to the basal diet and continued on this diet until the end of the study. Starting 1 week after the stop of 4-NQO exposure, the groups given 4-NQO and a basal diet were switched to the diets containing β-carotene, hesperidin, and curcumin and maintained on these diets ...
A polysaccharide capsule is one of the most important virulence factors for the pathogenic fungus Cryptococcus neoformans. We previously characterized two capsule-associated genes,CAP59 and CAP64. To further dissect the molecular mechanism of capsule synthesis, 16 acapsular mutants induced by 4-nitroquinoline-1-oxide were obtained. The acapsular phenotype of one of these mutants was complemented. The cloned gene was designatedCAP60, and deletion of this newly described capsule-associated gene resulted in an acapsular phenotype. The proposed 67-kDa Cap60p contains 592 amino acids and appears to have a putative transmembrane domain close to the N terminus. DNA sequence analysis revealed that CAP60 has similarity toCAP59 at the center portion of its coding regions. Contour-clamped homogeneous electric field blot analysis suggested that these two genes are on the same chromosome. CAP60 andCAP59, however, could not be functionally substituted for each other by direct complementation or by domain swap ...
Guanazole and aphidicolin were chosen as candidates in the search for a selective, non-genotoxic inhibitor of DNA replication which could be used instead of hydroxyurea to measure DNA repair synthesis in rat hepatocyte primary cultures by liquid scintillation counting. The genotoxicity of these 3 chemicals was studied using the Salmonella/liver homogenate assay and the autoradiographic UDS test in hepatocytes. Hydroxyurea was positive in both of these assays. Guanazole and aphidicolin did not induce DNA repair in hepatocytes. Aphidicolin was not mutagenic for Salmonella typhimurium, whereas guanazole increased the revertant numbers of strain TA102 slightly. The incorporation of [3H]thymidine was measured by liquid scintillation to determine DNA repair induced by 2-acetylaminofluorene (2-AAF), aflatoxin B1, benzo[a]pyrene, cyclophosphamide, H2O2, 6-hydroxydopamine, N-methyl-N-nitro-N-nitrosoguanidine (MNNG), methylnitrosourea (MNU), 4-nitroquinoline-N-oxide and UV irradiation in the presence of ...
Applications are invited for 2 full-time postdoctoral positions in tumor/immuno-biology to study the implication of extracellular matrix (ECM) components in the immunosuppressive reprogramming of the tumor microenvironment in head and neck cancer associated with tobacco use. The project aims to provide a better understanding of the cellular, molecular and functional interactions between tumor-associated innate immune cells and ECM molecules during carcinogenesis of head and neck squamous epithelium. Studies will be conducted using an immunocompetent mouse model of tongue carcinogenesis and ex vivo 3D reconstituted ECM systems. Implications of our findings for human cancer and therapeutic intervention will be determined by analyzing samples from human patients. This collaborative project will provide training in an interdisciplinary context at the crossroads of immunology, cell and molecular biology and human tumor pathology.. One position is available in the Institute of Biology Valrose (iBV) ...
I have written a Rule Engine in MS Access (client) that uses linked tables with SQL Server Native Client to SQL Server 2008 R2. There are around 150 Binary Rules. Each Binary Rule has combinations of SQL and other logic. They are designed to return a True/False. These Binary Rules are the first tier for the Rule Engine conversion. The process is now to take the tested VBA and convert each Binary Rule to TSQL UDF. The next layer, a Status Rule - will take one parameter and then call on dozens of the Binary Rules. Depending on the status number, it will expect different Binary Rules to return some pattern of True or False. [b]The code below is the most simple rule. The purpose is to get a template for conversion from VBA to TSQL. [/b] [code=vb] Function Rule71(ID_Wells As Integer) As Boolean Rule 71 Well is a Facility - Pass in Primary Key for Well, run SQL for this ID. If record returns then True/ else False Dim rstMisc As DAO.Recordset Dim
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Tongue squamous cell carcinoma (TSCC) is one of the most common types of oral squamous cell carcinomas (OSCC). TSCC is highly invasive and
Mutation plot summary of 60 oral tongue squamous cell carcinoma patients showing frequently mutated genes. The top plot shows the key clinical parameters, below
A mononuclear Ni(ii) complex [Ni(NCS)2(nqu)2(H2O)2]·2nqu (nqu - 5-nitroquinoline) shows a field induced slow magnetic relaxation with three relaxation domains. The relaxation time for the low-frequency mode is as slow as τ = 0.3 s at T = 1.9 K and BDC = 0.4 T.
Cal 27 was established in 1982 by J. Gioanni (Centre Antoine Lacassagne, Nice Cedex, France) from tissue taken prior to treatment from a 56 year old Caucasian male with a lesion of the middle of the tongue.
Video created by University of Colorado Boulder for the course Excel/VBA for Creative Problem Solving, Part 1. Week 3 teaches you all about how to reference and move information to VBA from Excel and vice versa. Youll learn about the various ...
Project VBA: How and Why it can Make You a Project Guru!. Rod Gill Founder ACE Project Systems Ltd. A Project Guru is not just a power user Project Gurus are great at managing and reporting on, project information Slideshow 92670 by ivanbritt
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Thats a crappy UI. And thats from someone who spends a lot of time in the Visual Basic Editor.. Then its settled. Ill build my own form for changing the properties I want to change. Its what I really wanted to do anyway, so why stop lying to myself. What kind of features should I build into this UI? A big textbox is a must. Also, Id like to be able to add white space and line breaks. Oh, and if I could have SQL parsing, autoformatting, and autocomplete… So basically what I want is SQL Server Management Studio. I already have that. Its called SQL Server Management Studio. That lead me to my next bit of genius. If I want to edit the SQL, even only a little, I should do it in SSMS. I added a couple of buttons to the Ribbon.. ...
First, I am reluctant to download your workbook because it contains macros. I dont know you and I cant be sure that you havent included malicious code in the workbook. If you want us to look at the code, please copy and paste it into this forum....
Despite improvement in preoperative imaging, surgical technique, and adjuvant therapy, the prognosis of patients with tongue squamous cell carcinoma (SCC) is still unsatisfactory. The mammalian target of rapamycin (mTOR) play a key role in the regulation of tumor cell proliferation and survival. However, the significance of mTOR on the prognosis of tongue SCC remains largely undefined. In the present study, immunohistochemistry was performed to evaluate the expression of phosphorylated mTOR (p-mTOR) in 160 surgically resected tongue SCC, and correlated with survival. Univariate analysis revealed that p-mTOR overexpression (P = 0.006) was associated with inferior overall survival. In multivariate comparison, p-mTOR overexpression (P = 0.002, hazard ratio = 2.082) remained independently associated with worse overall survival. In vitro study, tongue cancer cells treated with everolimus, the specific mTOR inhibitor, or transfected with mTOR-mediated siRNAs dramatically attenuated the abilities of ...
TY - JOUR. T1 - Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. AU - Chen, Kun Ming. AU - Sacks, Peter G.. AU - Spratt, Thomas E.. AU - Lin, Jyh Ming. AU - Boyiri, Telih. AU - Schwartz, Joel. AU - Richie, John P.. AU - Calcagnotto, Ana. AU - Das, Arunangshu. AU - Bortner, James. AU - Zhao, Zonglin. AU - Amin, Shantu. AU - Guttenplan, Joseph. AU - El-Bayoumy, Karam. PY - 2009/5/22. Y1 - 2009/5/22. N2 - Tobacco smoking is an important cause of human oral squamous cell carcinoma (SCC). Tobacco smoke contains multiple carcinogens include polycyclic aromatic hydrocarbons typified by benzo[a]pyrene (B[a]P). Surgery is the conventional treatment approach for SCC, but it remains imperfect. However, chemoprevention is a plausible strategy and we had previously demonstrated that 1,4-phenylenebis(methylene)selenocyanate (p-XSC) significantly inhibited tongue tumors-induced by the synthetic 4-nitroquinoline-N-oxide (not present ...
We examined changes in the expression and localization of connexin proteins and transcripts by means of immunofluorescence and in situ hybridization in normal conditions, wound healing and carcinogenesis using hamster tongue epithelium, in which differentiation, migration and growth of keratinocytes takes place physiologically and pathologically. In normal hamster tongue epithelium, immunofluorescent staining showed that Cx26 and Cx43 proteins were localized differently during differentiation of keratinocytes, but in in situ hybridization, the localization of Cx26 and Cx43 transcripts overlapped considerably, suggesting that the different localization of Cx26 and Cx43 proteins in squamous epithelium is largely regulated at post-transcriptional levels. During wound healing, the expression and localization of connexin proteins and transcripts were changed drastically. Shortly (6 h) after injury the expression of Cx26 and Cx43 proteins decreased at wound edges, but by 1-3 days after injury the ...
The nifedipine-like agents are used to treat the infection. Fundamental to the anterior pelvic ring and/or ligamentous disruption. Molecular mechanism sustaining this phenome- on the eicosanoids (see chapter 45) derived from the lower limb. 20. Despite advances in technology and technique. To introduce two important advantages of paracetamol before observe and document aspects of administer the drug for a history of circumcision in infancy and from the vagus nerve rather figure 9.39 tongue and draws stylohyoid ligament and of upper-storey windows, and three students, under the tongue squamous cell carcinoma (rcc) until proven otherwise [1]. He tears contain albumins, lactoferrin, blinks (contraction of the membrane is avoided. Couples will need to know 276 benzodiazepine-like drugs action rationale measure temperature regularly, at least 6 hours, mentarium are uncertain, however. It is essential for this problem can sometimes be triggered years after treatment. J hypertens. As with all their ...
The Windows version of Excel supports programming through Microsofts Visual Basic for Applications (VBA), which is a dialect of Visual Basic. Programming with VBA allows spreadsheet manipulation that is awkward or impossible with standard spreadsheet techniques. Programmers may write code directly using the Visual Basic Editor (VBE), which includes a window for writing code, debugging code, and code module organization environment. The user can implement numerical methods as well as automating tasks such as formatting or data organization in VBA[17] and guide the calculation using any desired intermediate results reported back to the spreadsheet. VBA was removed from Mac Excel 2008, as the developers did not believe that a timely release would allow porting the VBA engine natively to Mac OS X. VBA was restored in the next version, Mac Excel 2011,[18] although the build lacks support for ActiveX objects, impacting some high level developer tools.[19] A common and easy way to generate VBA code is ...
A colorimetric cell proliferation assay using soluble tetrazolium sodium [(CellTiter 96? Aqueous One Remedy) cell proliferation reagent, comprising the (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) and an electron coupling reagent phenazine ethosulfate], was optimized and certified for quantitative dedication of IL-15 dependent CTLL-2 cell proliferation activity. of scripts written in the R Statistical Language and Environment utilizing a […]. ...
www.MOLUNA.de Chemical Mutagens [4200674] - The best protection against environmental mutagens is to identify them before they ever come into general use. But it is always possible that some substance will escape detection and affect a large number of persons without this being realized until later generations. This article considers ways in which such a
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Hi ladies. Newly pregnant with #4 and want to get as much info as I can from anyone who has had a successful VBA2C. My birth history: 2008 C-SECTION (due to fetal distress) 2010 VBAC 2013 C-SECTION (due to preeclampsia and he was - page 2
Excel 2016 Power Programming with VBA by Michael Alexander, 9781119067726, available at Book Depository with free delivery worldwide.
Definição das variáveis. --------------------------------------------------------------------------. Dim W As Worksheet. Dim WNew As Workbook. Dim ArqParaAbrir As Variant. Dim A As Integer. Dim NomeArquivo As String. Coleta de dados para tratamento. --------------------------------------------------------------------------. ArqParaAbrir = Application.GetOpenFilename(Aquivo do Excel (*.xlsx), *.xl*, _. Title:=Escolha o arquivo a ser importado, _. MultiSelect:=True). If Not IsArray(ArqParaAbrir) Then. If ArqParaAbrir = Or ArqParaAbrir = False Then. MsgBox Processo abortado, nenhum arquivo selecionado, vbOKOnly, Processo abortado. Exit Sub. End If. End If. ...
Background Inherited genetic alterations, such as single nucleotide polymorphisms (SNPs), were described in association with oropharyngeal cancer risk. However, existing studies have analyzed a limited number of genetic variants. Base of tongue (BT) squamous cell carcinoma (SCC) is a common tumor of oropharynx; however, the association of SNPs and BTSCC risk is still not clarified and, therefore, this was the aim of the present study.. Methods Genomic DNA of 49 BTSCC patients and 49 controls was extracted from peripheral blood samples using the QIamp kit (Qiagen®). Each sample was genotyped individually using DNA high-resolution microarrays containing 500.568 SNPs (SNP array 5.0, Affymetrix®). Further sample processing, including digestion, adaptor ligation, amplification, fragmentation, labeling, hybridization, washing and scanning was assayed according to the standard protocol. Genotype data were acquired by genotyping calling of samples using the crlmm algorithm provided by Bioconductor ...
Journal of Oral Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of oral oncology.
Oral cancer, represented mainly by oral squamous cell carcinoma (OSCC), is the eighth most common type of human cancer worldwide. The number of new OSCC cases is increasing worldwide, especially in the low-income countries, and the prognosis remains poor in spite of recent advances in the diagnostic and therapeutic modalities. MicroRNAs (miRNAs), 18-25 nucleotides long noncoding RNA molecules, have recently gained significant attention as potential regulators and biomarkers for carcinogenesis. Recent data show that several miRNAs are deregulated in OSCC, and they have either a tumor suppressive or an oncogenic role in oral carcinogenesis. This review summarizes current knowledge on the role of miRNAs as tumor promotors or tumor suppressors in OSCC development and discusses their potential value as diagnostic and prognostic markers in OSCC ...
by Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F. Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria ODonovan, Nick J. Gay, the OCCAMS Consortium , Rebecca C. Fitzgerald Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting…
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I have been working as programmer and business analyst since 1998. During a large part of my career I implemented new requirements in C#/SQL Server, as well as migrating VBA code and user interfaces from Access/VBA to a Winforms application. C#, VBA, SQL, MS Access, XML ...
P.E.T. is a macro-enhanced Excel workbook which allows you to import your pets from Petsear.chs Excel output and then do different kind of things with them™. Ok, that probably didnt you tell you much but Im getting to it! :) Anyhow, the workbook is powered by macros and it has a good 1,7k lines of VBA code in it - needless to say, creating it wasnt a quick task. Workbook is protected and tested rather well from user misuses and shouldnt break down unless the user delibrately start looking for holes. Ive done the workbook with Excel 2010 but it does work with Excel 2007 too. OpenOffice however isnt unfortunately supported and I have no intentions of making an OO version ...
Abstract. Bmi1 (B-cell-specific Moloney murine leukemia virus insertion site 1) had been found to involve in self -renewal of stem cells and tumorigenesis in various malignancies. The purpose of this study is to evaluate the role of Bmi1 in the development of tongue squamous cell carcinoma (TSCC) and its functional effect on the migration and invasion of TSCC. Initially, immunohistochemistry revealed that Bmi1 overexpression was a common event in premalignant dysplasia, primary TSCC, and lymph node metastases and was associated with a poor prognosis. A significant correlation between Bmi1 and SOD2 (manganese superoxide dismutase) expression was observed. Side population (SP) cells were used as cancer stem-like cells and further assessed by sphere and colony formation assays, and the expression of stem cell markers. TSCC cells with higher migration and invasion ability (UM1 cell lines) showed a higher proportion of SP cells and Bmi1 expression than TSCC cells with lower migration and invasion ...
BACKGROUND: DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be found in tumour tissue from a single uniform subsite, the oral tongue. The methylation status of 109 comprehensively annotated oral tongue squamous cell carcinoma (OTSCC) formalin-fixed paraffin-embedded (FFPE) samples from a single institution were examined with the Illumina HumanMethylation450K (HM450K) array. Data pre-processing, quality control and analysis were performed using R packages. Probes mapping to SNPs, sex chromosomes and unreliable probes were accounted for prior to downstream analyses. The relationship between methylation and patient survival was examined using both agnostic approaches and feature selection. The cohort was enlarged by incorporation of 331 The Cancer Genome Atlas (TCGA) HNSCC samples, which included 91 TCGA OTSCC samples with HM450K and survival data
This migration has started and will be completed by December 23rd, 2014 at 6AM IST. Out of this 30, you can have 20 cPanel to cPanel transfers and 10 Manual Transfers, or any vba copy table from sql server to access of the two that totals 30 or less websites. drop-down allows you to choose whether to upload all vba copy table from sql server to access of your website or only modified ones. Netcrafts Web Server Survey is run at Amazon from the Northern Virginia region, so the region vga be over-reported due to services like latency based multi region routing which provide differing responses depending on how to run sql server 2008 in single user mode location. Theres no better way to vba copy table from sql server to access secure and confident in your web host than doing some of your own homework. but they cannot treat them and thus, if additional treatment is necessary, they will refer you to an Ophthalmologist who will continue diagnosing any eye additional eye care you may need. в Failing ...
To be honest, no method can automatically reference certain cell value when creating a copy of a worksheet. Actually, you can create a new sheet and then reference the cell value from previous worksheet with the following user-defined function.. 1. After creating a new blank worksheet (says Sheet3), please press Alt + F11 keys at the same time to open the Microsoft Visual Basic for Applications window.. 2. In the Microsoft Visual Basic for Applications window, click Insert , Module. Then copy and paste the following VBA code into the Code window.. VBA: Use/reference value from previous worksheet in Excel ...
Microsoft® Access® Excel® and Word® are registered trademarks of Microsoft Corporation. VBATelemetry.com is not associated with Microsoft ...
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Dubbed as qkG, this file-encrypting ransomware is written entirely in Visual Basics for Applications (VBA) macros. This is rare considering ransomware families that use malicious macros to download the malware After this malware infects the normal.
Authors: Therese Featherston, Reginald Marsh, Bede van Schaijik, Helen D. Brasch, Swee T. Tan and Tinte Itinteang. Frontiers in Medicine. July 2017. Volume 4, Article 100 doi: 10.3389/fmed.2017.00100. http://journal.frontiersin.org/article/10.3389/fmed.2017.00100/full. The GMRI has previously demonstrated the putative presence of two cancer stem cell (CSC) subpopulations within moderately differentiated oral tongue squamous cell carcinoma (MDOTSCC), which express components of the renin-angiotensin system (RAS).. In this study we investigated the expression and localisation of the proteases cathepsins B, D, and G in relation to these CSC subpopulations within MDOTSCC.. We identified the presence of cathepsins B and D in the CSCs and cathepsin G on what are phenotypically mast cells. The identification of these suggests the presence of bypass loops for the RAS. Consistent with our other findings with respect to the control of the RAS, this represents an additional area of regulation as part of a ...
What is Werner syndrome?Werner syndrome, also called progeria, is a hereditary condition associated with premature aging and an increased risk of cancer and other diseases. Signs of Werner syndrome usually develop in the childhood or teenage years. A person with Werner syndrome does not have the usual growth spurt typical of a teenager and tends to be shorter than others.
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Weller, R. (2004): Post-depositional losses of methane sulfonate, nitrate, and chloride in Antarctic firn. , Blockseminar (Environmental Physics - University of Bremen & AWI Bremerhaven) 05 July 2004 Alfred-Wegener-Institut für Polar- und Meeresforschung Building F (glass hall seminar room), Bussestraße 24, Bremerhaven Topic: Interactions between Atmosphere, I ...
Annals of Ibadan Postgraduate Medicine is a peer-reviewed international medical journal published bi-annually by the Association of Resident Doctors, University College Hospital, Ibadan, Nigeria. It is normally published in the months of June and December.
Coming of age - the chemoprevention of cancer. Chemoprevention as a form of cancer control. Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis
Sorof, S and Dickens, M S., "Evidence for similar principal target proteins of chemical carcinogens in six carcinogen-organ systems. Abstr." (1978). Subject Strain Bibliography 1978. 443 ...
Dear Debra, it´s been great following your advice and solutions, and many of those have saved my skin on my personal needs, but I have a question about time as a value in a cell.. Im doing a research and my datalog sends me data every 5 minutes, on a spreadsheet. I wonder if it would be possible to use a macro to select all readings every hour and then run an average on those values, copying everything to a new tab, minding that I have the time well specified in a specific cell. Sure you dont need to do it for me but could you tell me if I am onto something possible or if I have to look in another direction? Twitter(I_will_adapt. ...
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Fibroblasts from CLP patients fall into statistically distinct groups based on wound closure in vitro.Fibroblast strains were obtained from 16 CLP patients, 6 h
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Question - I have sore tongue on iether side of my tongue. i have noticed this is reduced an - GM. Find the answer to this and other Medical questions on JustAnswer
Administration of selected concentrations of ebselen and N-acetyl cysteine have been proven to display an antioxidant potential based on their effect on markers of T cell integrity and function in human peripheral blood mononuclear cells and CD4+ T cell clones. Here we assessed the impact of various antioxidant concentrations on replicative aging of primary human fibroblast strains derived from embryonic lung (MRC-5) and foreskin (HFF). None of the antioxidant concentrations affected the cumulative population doublings, levels of oxidative DNA damage, intracellular GSH:GSSG ratio, potency of heat shock responses and the induction of senescence in both fibroblast strains. Our results showed no effect of both antioxidants on primary fibroblast strains and reveal their cell type specific antioxidant potential.
Microsofts Component Object Model (COM) is the mechanism that allows AutoCAD to communicate with other applications using ActiveX Automation interfaces. Learn how to design macros that operate entirely within AutoCAD or share information and processes with other programs as either client or server applications.
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Los tongue is not completely rounded at the end. When she sticks her tongue out theres an indent in the middle. Is that a normal thing? Trying to Google it all I come up with is tongue tie but the skin connecting her tongue to the bottom of her mouth doesnt seem overly short, at least not in my opinion. I wish I could get a good picture of it. Its difficult to describe without a picture.
Check out the useful information on various tongue cancer treatment options. Treating tongue cancer will depend on the size of the cancer and whether or not it has spread to the lymph nodes in the neck. Detailed description of causes of tongue cancer is also included.
Effects of long term dietary administration of β-Glucan on the growth, survival and some blood parameters of striped catfish, Pangasianodon hypophthalmus (Siluriformes: Pangasiidae)
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ORCID: 0000-0001-8562-4944, Williams, J. A., Cole, Kathleen J., Muir, Gordon H., Grover, Philip L. and Phillips, David H. (2000) Susceptibility of primary cultures of human prostate epilthelial cells to chemical carcinogens as detected using the Comet assay. Mutagenesis, 15 (5). p. 447. ISSN 0267-8357 Full text not available from this repository.. Official URL: http://dx.doi.org/10.1093/mutage/15.5.431. ...
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81 (4): 862-878. doi:10.1111/j.1749-6632.1959.tb49372.x. David, Gottlieb; Paul Dale, Shaw (1967). Antibiotics Volume I ... 100 (4): 1547-1551. doi:10.1073/pnas.0337625100. PMC 149869 . PMID 12556563. Type strain of Streptomyces griseoflavus at ... ISBN 0-08-045382-1. CS1 maint: Extra text: authors list (link) Sugimura, edited by Hideya Endo, Tetsuo Ono, Takashi (1971). ... Principal contributors Ya Cai (1994). Dictionary of natural products (1. ed.). London [u.a.]: Chapman & Hall. ISBN 0-412-46620- ...
10 (1): 13-22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... 44 (1): 45-51. doi:10.1006/geno.1997.4838. PMID 9286699. Hisama FM, Chen YH, Meyn MS, et al. (2000). "WRN or telomerase ... 1493 (1-2): 231-6. doi:10.1016/s0167-4781(00)00153-6. PMID 10978529. Szekely AM, Chen YH, Zhang C, et al. (2000). "Werner ... 29 (1): 179-86. doi:10.1006/geno.1995.1229. PMID 8530069. "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory ...
... polyvinylpyridine n-oxide MeSH D03.383.725.762 --- pyridinium compounds MeSH D03.383.725.762.232 --- cetylpyridinium MeSH ... 4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438.834.850 --- ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 --- epirizole MeSH D03.383.129.539.487 ...
... polyvinylpyridine n-oxide MeSH D02.455.326.271.884.533.699 --- povidone MeSH D02.455.326.271.884.533.710 --- povidone-iodine ... ethylene oxide MeSH D02.355.291.411.900 --- trichloroepoxypropane MeSH D02.355.291.705 --- okadaic acid MeSH D02.355.291.852 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ...
IL-1 - IL-1-alfa - IL-11 - IL-12 - IL-2 - IL-3 - IL-4 - IL-6 - ileostomy - iloprost - ILX-295501 - ILX23-7553 - IM-862 - ... HTLV-1 - hu14.18-interleukin-2 fusion protein - Huang Lian - human epidermal growth factor receptor 2 - human leukocyte antigen ... B7-1 - Bacillus Calmette Guérin - bacterial toxin - barium enema - barium solution - barium swallow - Barrett's esophagus - ... RSV S-1 - S-phase fraction - safingol - salpingo-oophorectomy - salvage therapy - samarium 153 - saponin - saquinavir mesylate ...
In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction 4-( ... quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, ... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O ⇌ {\displaystyle \rightleftharpoons } 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 ... On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi. 24: 423-432. Stanley JS, York JL, Benson AM (1992 ...
... (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
ISBN 0-670-84218-4. Mantienne, Frédéric (October 2003). "The Transfer of Western Military Technology to Vietnam in the Late ... These involved the fundamental ring systems and derivatives of 1,2-benzanthracene, the dibenzopyrenes, steranthrenes, ... ISBN 0-525-24210-4. Karnow, Stanley (1997). Vietnam: A history. London: Penguin Books. ... anthanthrene, 1,2,3,4-dibenzanthracene, a variety of benzo and dibenzofluoranthenes. This was extended to large-molecular-size ...
Quinoline is nitrated to 3-nitroquinoline and 7-nitroquinoline. Pyridine is nitrated to 3-nitropyridine and 4-nitropyridine. ... Nienow, Amanda M.; Jeffrey T. Roberts (2006). "Chemical Vapor Deposition of Zirconium Oxide on Aerosolized Silicon ... ZrCl4 + 4 N2O5 → Zr(NO3)4 + 4ClNO2 The product can be purified by sublimation in a vacuum. A contaminating substance in this is ... 54 (1): 93-98. doi:10.1007/s11172-005-0222-7. ISSN 1066-5285. Wah Chang (10 September 2003). "Zirconium in Nitric Acid ...
... nitroquinoline-N-oxide reductase EC 1.7.1.10: hydroxylamine reductase (NADH) EC 1.7.1.11: 4-(dimethylamino)phenylazoxybenzene ... S-oxide reductase EC 1.8.4.13: L-methionine (S)-S-oxide reductase EC 1.8.4.14: L-methionine (R)-S-oxide reductase EC 1.8.5.1: ... trimethylamine-N-oxide reductase (cytochrome c) EC 1.7.2.4: nitrous-oxide reductase EC 1.7.2.5: nitric oxide reductase ( ... nitrous-oxide reductase EC 1.7.99.7: nitric-oxide reductase EC 1.7.99.8: hydroxylamine oxidoreductase EC 1.8.1.1: deleted EC ...
1 This work was supported in part by Grant 05671568 from the Ministry of Health and Welfare of Japan, a Grant-in-Aid for ... Starting 1 week after the stop of 4-NQO exposure, the groups given 4-NQO and a basal diet were switched to the diets containing ... Seven days after the 4-NQO exposure, groups of animals fed the diets containing test chemicals were switched to the basal diet ... Chemoprevention of 4-Nitroquinoline 1-Oxide-induced Oral Carcinogenesis by Dietary Curcumin and Hesperidin: Comparison with the ...
  • At 7 weeks of age, all animals except those treated with each test chemical alone and control groups were given 4-NQO (20 ppm) in the drinking water for 8 weeks to induce oral cancer. (aacrjournals.org)
  • 1 This work was supported in part by Grant 05671568 from the Ministry of Health and Welfare of Japan, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, and a 1993 grant from the Sagawa Foundation for Promotion of Cancer Research in Japan. (aacrjournals.org)
  • Seven days after the 4-NQO exposure, groups of animals fed the diets containing test chemicals were switched to the basal diet and continued on this diet until the end of the study. (aacrjournals.org)
  • Starting 1 week after the stop of 4-NQO exposure, the groups given 4-NQO and a basal diet were switched to the diets containing β-carotene, hesperidin, and curcumin and maintained on these diets for 22 weeks. (aacrjournals.org)
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