4-Nitroquinoline-1-oxide: A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.Nitroquinolines: Quinolines substituted in any position by one or more nitro groups.Tongue Neoplasms: Tumors or cancer of the TONGUE.4-Hydroxyaminoquinoline-1-oxide: A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.Tongue: A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.Hesperidin: A flavanone glycoside found in CITRUS fruit peels.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Pronase: A proteolytic enzyme obtained from Streptomyces griseus.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Aminoquinolines: Quinolines substituted in any position by one or more amino groups.Mouth Neoplasms: Tumors or cancer of the MOUTH.QuinolinesPapilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)PolyaminesAnticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Rats, Inbred F344Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Nitric Oxide Synthase Type I: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
(1/242) Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide.

The yeast gene SNQ2, which encodes a multidrug resistance ABC superfamily protein, is required for resistance to the mutagen 4-nitroquinoline N-oxide (4-NQO). The expression of the SNQ2 gene is under the control of a regulatory network that involves the transcription factor Yrr1p, as well as Pdr1p/Pdr3p (Cui et al., Mol. Microbiol., 29, 1307-1315 (1998)). By 5'-deletion analysis of the promoter by using SNQ2-lacZ fusion constructs, four regions: -745 to -639 (region I), -639 to -578 (region II), -548 to -533 (region III) and -533 to -485 (region IV) were found to be important for SNQ2 expression. Genetic analysis suggested that the site in region IV was responsible for the Yrr1p-mediated SNQ2 expression. A consensus motif known for the binding of Pdr1p/Pdr3p (PDRE) was not found in region IV.  (+info)

(2/242) Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine.

The effects of three widely differing chemical carcinogens, 4-nitroquinoline 1-oxide, Adriamycin, and ethyleneimine, on DNA replication were studied by pulse labeling of DNA with [3H]thymidine and sedimentation analysis with alkaline sucrose gradients. At doses that reduced the rate of DNA synthesis to 30 to 60% of control values, only ethyleneimine produced damage that resulted in lower molecular weights of parental DNA. All three chemicals inhibited replicon initiation, but to differing extents. Inhibition of replicon initiation was the first clearly identified effect of 4-nitroquinoline 1-oxide and was the main cause of inhibition of DNA synthesis. Ethyleneimine caused severe inhibition of replicon initiation, but blocks to chain elongation also contributed significantly to the inhibition of overall DNA synthesis. Adriamycin affected replicon initiation to a small but significant extent; the primary cause of inhibition of DNA synthesis by this drug was a slowing of the rate of chain elongation. These results indicate that inhibition of replicon initiation is an important mechanism for the action of DNA-damaging agents in mammalian cells and strengthen the concept that control of DNA replication depends on the structural integrity of a chromosomal subunit that consists of several replicons.  (+info)

(3/242) Inverse correlation between p53 protein levels and DNA repair efficiency in human fibroblast strains treated with 4-nitroquinoline 1-oxide: evidence that lesions other than DNA strand breaks trigger the p53 response.

Ionizing radiation-induced stabilization and the resultant transient accumulation of the p53 tumor suppressor protein is impaired in cells from ataxia telangiectasia (AT) patients, indicating a key role for ATM, the gene mutated in AT, upstream in the radiation-responsive p53 signaling pathway. Activation of this pathway is generally assumed to be triggered by DNA strand breaks produced directly following genotoxic stress or indirectly during excision repair of DNA lesions. The aim of this study was to identify the triggering signal for induction of p53 in diploid human dermal fibroblasts treated with 4-nitroquinoline 1-oxide (4NQO), a model environmental carcinogen that produces both DNA strand breaks (like ionizing radiation) and alkali-stable bulky DNA lesions (like UV light). 4NQO treatment of fibroblasts cultured from normal and AT donors and those from patients with the UV-hypersensitivity disorder xeroderma pigmentosum (XP, complementation groups A, E and G) resulted in up-regulation of p53 protein. In normal fibroblasts, there was no temporal relationship between the incidence of DNA strand breaks and levels of p53 protein; >90% of strand breaks and alkali-labile sites were repaired over 2 h following treatment with 1 microM 4NQO, whereas approximately 3 h of post-treatment incubation was required to demonstrate a significant rise in p53 protein. In contrast, exposure of normal fibroblasts to gamma-rays resulted in a rapid up-regulation of p53 and the level peaked at 2 h post-irradiation. XP cells with a severe deficiency in the nucleotide excision repair pathway showed abnormally high levels of p53 protein in response to 4NQO treatment, indicating that lesions other than incision-associated DNA strand breaks trigger p53 up-regulation. We observed a consistent, inverse correlation between the ability of the various fibroblast cultures to induce p53 following 4NQO treatment and their DNA repair efficiencies. Treatment with 0.12 microM 4NQO, for example, caused a >2-fold up-regulation of p53 in excision repair-deficient (AT, XPA and XPG) strains without eliciting any effect on p53 levels in repair-proficient (normal and XPE) strains. We conclude that up-regulation of p53 by 4NQO is mediated solely by an ATM-independent mechanism and that the p53 response is primarily triggered by persistent alkali-stable 4NQO-DNA adducts.  (+info)

(4/242) Development of a new bioluminescent mutagenicity assay based on the Ames test.

A newly developed rapid mutagenicity assay based on the adenosine triphosphate (ATP)-bioluminescence technique and the Ames test is described. Salmonella typhimurium strains TA98 and TA100 were exposed in an appropriate liquid medium to the direct mutagens 4-nitroquinoline-N-oxide and methyl methanesulphonate, respectively, and to the indirect mutagen 2-aminoanthracene. Both auxotrophic and prototrophic growth were monitored throughout the incubation period as variations in the intracellular ATP levels by means of the luciferin-luciferase assay. After 9-12 h of incubation a dose-response increase in the levels of ATP was readily detected. In order to demonstrate that this increase was due to the growth of revertant bacteria, aliquots from each culture were plated on minimal agar plates. A very good correlation between the changes in ATP levels and the appearance of revertant colonies on the plates was found. Given the rapidity of this method as compared with conventional mutagenicity assays, it has potential for industrial and environmental applications. Other potential applications are also discussed.  (+info)

(5/242) Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which many characteristics of aging are accelerated. A probable role in some aspect of DNA metabolism is suggested by the primary sequence of the WRN gene product. A recombinant His-tagged WRN protein (WRNp) was overproduced in insect cells using the baculovirus system and purified to near homogeneity by several chromatographic steps. This purification scheme removes both nuclease and topoisomerase contaminants that persist following a single Ni(2+)affinity chromatography step and allows for unambiguous interpretation of WRNp enzymatic activities on DNA substrates. Purified WRNp has DNA-dependent ATPase and helicase activities consistent with its homology to the RecQ subfamily of proteins. The protein also binds with higher affinity to single-stranded DNA than to double-stranded DNA. However, WRNp has no higher affinity for various types of DNA damage, including adducts formed during 4NQO treatment, than for undamaged DNA. Our results confirm that WRNp has a role in DNA metabolism, although this role does not appear to be the specific recognition of damage in DNA.  (+info)

(6/242) Regulation of the ribonucleotide reductase small subunit gene by DNA-damaging agents in Dictyostelium discoideum.

In Escherichia coli, yeast and mammalian cells, the genes encoding ribonucleotide reductase, an essential enzyme for de novo DNA synthesis, are up-regulated in response to DNA damaging agents. We have examined the response of the rnrB gene, encoding the small subunit of ribonucleotide reductase in Dictyostelium discoideum, to DNA damaging agents. We show here that the accumulation of rnrB transcript is increased in response to methyl methane sulfonate, 4-nitroquinoline-1-oxide and irradiation with UV-light, but not to the ribonucleotide reductase inhibitor hydroxyurea. This response is rapid, transient and independent of protein synthesis. Moreover, cells from different developmental stages are able to respond to the drug in a similar fashion, regardless of the basal level of expression of the rnrB gene. We have defined the cis -acting elements of the rnrB promoter required for the response to methyl methane sulfonate and 4-nitroquinoline-1-oxide by deletion analysis. Our results indicate that there is one element, named box C, that can confer response to both drugs. Two other boxes, box A and box D, specifically conferred response to methyl methane sulfonate and 4-nitroquinoline-1-oxide, respectively.  (+info)

(7/242) Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae.

Rsp5 is an E3 ubiquitin-protein ligase of Saccharomyces cerevisiae that belongs to the hect domain family of E3 proteins. We have previously shown that Rsp5 binds and ubiquitinates the largest subunit of RNA polymerase II, Rpb1, in vitro. We show here that Rpb1 ubiquitination and degradation are induced in vivo by UV irradiation and by the UV-mimetic compound 4-nitroquinoline-1-oxide (4-NQO) and that a functional RSP5 gene product is required for this effect. The 26S proteasome is also required; a mutation of SEN3/RPN2 (sen3-1), which encodes an essential regulatory subunit of the 26S proteasome, partially blocks 4-NQO-induced degradation of Rpb1. These results suggest that Rsp5-mediated ubiquitination and degradation of Rpb1 are components of the response to DNA damage. A human WW domain-containing hect (WW-hect) E3 protein closely related to Rsp5, Rpf1/hNedd4, also binds and ubiquitinates both yeast and human Rpb1 in vitro, suggesting that Rpf1 and/or another WW-hect E3 protein mediates UV-induced degradation of the large subunit of polymerase II in human cells.  (+info)

(8/242) The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair.

Cockayne syndrome (CS) is a human genetic disorder characterized by UV sensitivity, developmental abnormalities, and premature aging. Two of the genes involved, CSA and CSB, are required for transcription-coupled repair (TCR), a subpathway of nucleotide excision repair that removes certain lesions rapidly and efficiently from the transcribed strand of active genes. CS proteins have also been implicated in the recovery of transcription after certain types of DNA damage such as those lesions induced by UV light. In this study, site-directed mutations have been introduced to the human CSB gene to investigate the functional significance of the conserved ATPase domain and of a highly acidic region of the protein. The CSB mutant alleles were tested for genetic complementation of UV-sensitive phenotypes in the human CS-B homologue of hamster UV61. In addition, the CSB mutant alleles were tested for their ability to complement the sensitivity of UV61 cells to the carcinogen 4-nitroquinoline-1-oxide (4-NQO), which introduces bulky DNA adducts repaired by global genome repair. Point mutation of a highly conserved glutamic acid residue in ATPase motif II abolished the ability of CSB protein to complement the UV-sensitive phenotypes of survival, RNA synthesis recovery, and gene-specific repair. These data indicate that the integrity of the ATPase domain is critical for CSB function in vivo. Likewise, the CSB ATPase point mutant failed to confer cellular resistance to 4-NQO, suggesting that ATP hydrolysis is required for CSB function in a TCR-independent pathway. On the contrary, a large deletion of the acidic region of CSB protein did not impair the genetic function in the processing of either UV- or 4-NQO-induced DNA damage. Thus the acidic region of CSB is likely to be dispensable for DNA repair, whereas the ATPase domain is essential for CSB function in both TCR-dependent and -independent pathways.  (+info)

*  4-Nitroquinoline 1-oxide
... (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
*  Streptomyces griseoflavus
81 (4): 862-878. doi:10.1111/j.1749-6632.1959.tb49372.x. David, Gottlieb; Paul Dale, Shaw (1967). Antibiotics Volume I ... 100 (4): 1547-1551. doi:10.1073/pnas.0337625100. PMC 149869 . PMID 12556563. Type strain of Streptomyces griseoflavus at ... ISBN 0-08-045382-1. CS1 maint: Extra text: authors list (link) Sugimura, edited by Hideya Endo, Tetsuo Ono, Takashi (1971). ... Principal contributors Ya Cai (1994). Dictionary of natural products (1. ed.). London [u.a.]: Chapman & Hall. ISBN 0-412-46620- ...
*  Nitroquinoline-N-oxide reductase
In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction 4-( ... quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, ... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O ⇌ {\displaystyle \rightleftharpoons } 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 ... On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi. 24: 423-432. Stanley JS, York JL, Benson AM (1992 ...
*  POLD2
10 (1): 13-22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... 44 (1): 45-51. doi:10.1006/geno.1997.4838. PMID 9286699. Hisama FM, Chen YH, Meyn MS, et al. (2000). "WRN or telomerase ... 1493 (1-2): 231-6. doi:10.1016/s0167-4781(00)00153-6. PMID 10978529. Szekely AM, Chen YH, Zhang C, et al. (2000). "Werner ... 29 (1): 179-86. doi:10.1006/geno.1995.1229. PMID 8530069. "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory ...
*  List of MeSH codes (D03)
... polyvinylpyridine n-oxide MeSH D03.383.725.762 --- pyridinium compounds MeSH D03.383.725.762.232 --- cetylpyridinium MeSH ... 4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438.834.850 --- ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 --- epirizole MeSH D03.383.129.539.487 ...
*  List of MeSH codes (D02)
... polyvinylpyridine n-oxide MeSH D02.455.326.271.884.533.699 --- povidone MeSH D02.455.326.271.884.533.710 --- povidone-iodine ... ethylene oxide MeSH D02.355.291.411.900 --- trichloroepoxypropane MeSH D02.355.291.705 --- okadaic acid MeSH D02.355.291.852 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ...
*  Index of oncology articles
IL-1 - IL-1-alfa - IL-11 - IL-12 - IL-2 - IL-3 - IL-4 - IL-6 - ileostomy - iloprost - ILX-295501 - ILX23-7553 - IM-862 - ... HTLV-1 - hu14.18-interleukin-2 fusion protein - Huang Lian - human epidermal growth factor receptor 2 - human leukocyte antigen ... B7-1 - Bacillus Calmette Guérin - bacterial toxin - barium enema - barium solution - barium swallow - Barrett's esophagus - ... RSV S-1 - S-phase fraction - safingol - salpingo-oophorectomy - salvage therapy - samarium 153 - saponin - saquinavir mesylate ...
*  Bửu Hội
ISBN 0-670-84218-4. Mantienne, Frédéric (October 2003). "The Transfer of Western Military Technology to Vietnam in the Late ... These involved the fundamental ring systems and derivatives of 1,2-benzanthracene, the dibenzopyrenes, steranthrenes, ... ISBN 0-525-24210-4. Karnow, Stanley (1997). Vietnam: A history. London: Penguin Books. ... anthanthrene, 1,2,3,4-dibenzanthracene, a variety of benzo and dibenzofluoranthenes. This was extended to large-molecular-size ...
*  Zirconium nitrate
Quinoline is nitrated to 3-nitroquinoline and 7-nitroquinoline. Pyridine is nitrated to 3-nitropyridine and 4-nitropyridine. ... Nienow, Amanda M.; Jeffrey T. Roberts (2006). "Chemical Vapor Deposition of Zirconium Oxide on Aerosolized Silicon ... ZrCl4 + 4 N2O5 → Zr(NO3)4 + 4ClNO2 The product can be purified by sublimation in a vacuum. A contaminating substance in this is ... 54 (1): 93-98. doi:10.1007/s11172-005-0222-7. ISSN 1066-5285. Wah Chang (10 September 2003). "Zirconium in Nitric Acid ...
*  List of EC numbers (EC 1)
... nitroquinoline-N-oxide reductase EC 1.7.1.10: hydroxylamine reductase (NADH) EC 1.7.1.11: 4-(dimethylamino)phenylazoxybenzene ... S-oxide reductase EC 1.8.4.13: L-methionine (S)-S-oxide reductase EC 1.8.4.14: L-methionine (R)-S-oxide reductase EC 1.8.5.1: ... trimethylamine-N-oxide reductase (cytochrome c) EC 1.7.2.4: nitrous-oxide reductase EC 1.7.2.5: nitric oxide reductase ( ... nitrous-oxide reductase EC 1.7.99.7: nitric-oxide reductase EC 1.7.99.8: hydroxylamine oxidoreductase EC 1.8.1.1: deleted EC ...
4-nitroquinoline-n-oxide | VWR  4-nitroquinoline-n-oxide | VWR
Learn more about 4-nitroquinoline-n-oxide. We enable science by offering product choice, services, process excellence and our ... Phone: 1-800-932-5000. Online: Contact Us. Contact VWR Web & B2B Integration Support:. Phone: 1-888-320-4357. Online: Help ... If you need further assistance, please call VWR Customer Service at 1-800-932-5000. ... is still displayed and you need assistance, please call us at 1-800-932-5000. ...
more infohttps://us.vwr.com/store/product/8907983/4-nitroquinoline-n-oxide
5-Chloro-4-nitroquinoline 1-oxide | C9H5ClN2O3 - PubChem  5-Chloro-4-nitroquinoline 1-oxide | C9H5ClN2O3 - PubChem
5-Chloro-4-nitroquinoline 1-oxide , C9H5ClN2O3 , CID 84188 - structure, chemical names, physical and chemical properties, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/84188
4-Nitroquinoline 1-oxide - Wikipedia  4-Nitroquinoline 1-oxide - Wikipedia
4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
more infohttps://en.wikipedia.org/wiki/4-Nitroquinoline_1-oxide
Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells | Cancer Research  Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells | Cancer Research
1 This investigation was supported in part by Grants CA 13747, CA 19283, and CA 15901 awarded by the National Cancer Institute ... Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells. Marie E. Varnes and ... The carcinogen 4-nitroquinoline 1-oxide (4-NQO) was found to rapidly deplete non-protein thiols (NPSH) from Ehrlich ascites ... The NPSH thus appeared to play a significant role in 4-NQO detoxification. Glutathione, when present in culture medium during 4 ...
more infohttp://cancerres.aacrjournals.org/content/39/8/2960?ijkey=db2538f795c64a1f2b1e689d45c44dd0dafc8d65&keytype2=tf_ipsecsha
Effect of a Potent Carcinogen, 4-Nitroquinoline 1-Oxide, and Its Reduced Form, 4-Hydroxylaminoquinoline 1-Oxide, on Bacterial...  Effect of a Potent Carcinogen, 4-Nitroquinoline 1-Oxide, and Its Reduced Form, 4-Hydroxylaminoquinoline 1-Oxide, on Bacterial...
1 Supported in part by NIH Grants AI-06429 and CA-10439, USPHS, and National Science Foundation Grant NSF-GB-8503. The work ... 4-Nitroquinoline 1-oxide (4NQO)-sensitive mutants of Salmonella typhimurium were found to be sensitive to ultraviolet light (UV ... Effect of a Potent Carcinogen, 4-Nitroquinoline 1-Oxide, and Its Reduced Form, 4-Hydroxylaminoquinoline 1-Oxide, on Bacterial ... Effect of a Potent Carcinogen, 4-Nitroquinoline 1-Oxide, and Its Reduced Form, 4-Hydroxylaminoquinoline 1-Oxide, on Bacterial ...
more infohttp://cancerres.aacrjournals.org/content/30/10/2532
Repair of DNA damage after exposure to 4-nitroquinoline-1-oxide in heterokaryons derived from xeroderma pigmentosum cells. -...  Repair of DNA damage after exposure to 4-nitroquinoline-1-oxide in heterokaryons derived from xeroderma pigmentosum cells. -...
XP cells are not only abnormally sensitive to UV, but also to a variety of chemical carcinogens, including 4-nitro-quinoline-1- ... oxide (4NQO). Complementation analysis with XP strains from 4 different complementation groups with respect to the repair of ... Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide.. Elizabeth G ... XP cells are not only abnormally sensitive to UV, but also to a variety of chemical carcinogens, including 4-nitro-quinoline-1- ...
more infohttps://www.semanticscholar.org/paper/Repair-of-DNA-damage-after-exposure-to-in-derived-Zelle-Bootsma/9d7c8c92880a13e19f6b45aeb3a52f11d7cf3d46
Navegação  por assunto 4-nitroquinoline 1-oxide  Navegação por assunto "4-nitroquinoline 1-oxide"
Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationship ... Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide  ... The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide  ... Imbalance of Tumor Suppression Genes Expression Following Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide  ...
more infohttp://vml029.epm.br/browse?value=4-nitroquinoline+1-oxide&type=subject
4-NITROQUINOLINE 1-OXIDE meaning in English, значение слова. NCI English Dictionary of Cancer Terms  4-NITROQUINOLINE 1-OXIDE meaning in English, значение слова. NCI English Dictionary of Cancer Terms
4-NQO. A substance that is used in cancer research to cause tumors in laboratory animals. This is done to test new diets, drugs ... OXIDE - оксид - acid oxide - aluminium oxide - calcium oxide - carbonic oxide - chrome oxide - copper oxide - cupric oxide - ... OXIDE - n. calcium oxide deuterium oxide nitric oxide nitrous oxide oxide mineral. Britannica Concise Encyclopedia ... OXIDE - окись; оксид - calcium oxide - lead oxide - oxide of aluminium - zinc oxide. Англо-Русский словарь по строительству и ...
more infohttps://slovar-vocab.com/english/nci-cancer-terms-vocab/4-nitroquinoline-1-oxide-6062585.html
IJMS | Free Full-Text | The Peroxisome Proliferator-Activated Receptor (PPAR)  α Agonist Fenofibrate Suppresses Chemically...  IJMS | Free Full-Text | The Peroxisome Proliferator-Activated Receptor (PPAR) α Agonist Fenofibrate Suppresses Chemically...
They were then fed a diet containing 0.01% or 0.05% fenofibrate for 29 weeks, starting 1 week after 4-NQO administration. At ... The incidence and multiplicity of lesions were significantly lower in mice treated with 4-NQO and 0.05% fenofibrate compared ... Our results indicate that fenofibrate can prevent the development of 4-NQO-induced proliferative lesions in the lung by ... This study was designed to determine whether fenofibrate, a PPARα agonist, can suppress 4-nitroquinoline 1-oxide (4-NQO)- ...
more infohttps://www.mdpi.com/1422-0067/15/5/9160
Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics | IntechOpen  Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics | IntechOpen
These data are edited from Figure 1 of Ref. [48] for BY4741, Δerg6, 12geneΔ0, and 12geneΔ0HSR, or Figure 2 of Ref. [49] for ... The work flow is shown in Figure 1. As a first step, we focused on drug efflux systems. The drug efflux system composed of ABC ... 2.2.1. Availability of 12geneΔ0HSR-iERG6 in drug screening. In general, S. cerevisiae exhibits high levels of drug resistance, ... Figure 1.. The work flow of the construction of multidrug-sensitive strains. (A) The parental strain, BY4741, possesses high ...
more infohttps://www.intechopen.com/books/the-yeast-role-in-medical-applications/multidrug-sensitive-yeast-strains-useful-tools-for-chemical-genetics
Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced...  Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced...
2002 Jun 27;518(1):85-93. Research Support, U.S. Gov't, P.H.S. ... Guttenplan JB1, Kosinska W, von Pressentin Md, Rosa J, El- ... 4-NQO was a potent mutagen in tongue, other pooled oral tissues and esophagus when given in drinking water for 4 weeks at a ... 1. Division of Basic Sciences/Biochemistry, New York University, Dental Center, 345 E. 24th St., New York, NY 10100, USA. ... Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12063070?dopt=Abstract
Molecules  | Free Full-Text | Cancer Chemoprevention by Carotenoids | HTML  Molecules | Free Full-Text | Cancer Chemoprevention by Carotenoids | HTML
Figure 1. Chemical structures of (a) α-carotene; (b) β-carotene; (c) lycopene; (d) β-cryptoxanthin; (e) lutein; (f) zeaxantin ... Figure 1. Chemical structures of (a) α-carotene; (b) β-carotene; (c) lycopene; (d) β-cryptoxanthin; (e) lutein; (f) zeaxantin ... Cancer 1992, 18, 1-29. [Google Scholar] [CrossRef]. *Blot, W.J.; Li, J.Y.; Taylor, P.R.; Guo, W.; Dawsey, S.; Wang, G.Q.; Yang ... A recent study of ours indicated that db/db-ApcMin/+ with increased expression of IGF-1, IGF-1R and IGF-2 in the intestine was ...
more infohttps://www.mdpi.com/1420-3049/17/3/3202/htm
Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. -...  Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. -...
Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.. *Yi Jiang, Liyan Liao, +6 authors ... Phospholipase C gamma 1 is a potential prognostic biomarker for patients with locally advanced and resectable oral squamous ...
more infohttps://www.semanticscholar.org/paper/Phospholipase-C-gamma1-is-required-for-the-growth-Xie-Chen/0910ef7d6d606003ce447273fa06fb10d536be70
EC 1.7 and EC 1.8  EC 1.7 and EC 1.8
Accepted name: nitroquinoline-N-oxide reductase. Reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4- ... Accepted name: nitric oxide reductase (cytochrome c). Reaction: nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ... EC 1.7.2.3 trimethylamine-N-oxide reductase (cytochrome c). EC 1.7.2.4 nitrous-oxide reductase. EC 1.7.2.5 nitric oxide ... Accepted name: nitric oxide reductase (menaquinol). Reaction: 2 nitric oxide + menaquinol = nitrous oxide + menaquinone + H2O. ...
more infohttps://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC1/07p.html
Phenomenex GC Application #16413: EPA Method 8270C ZB-5MSi  Phenomenex GC Application #16413: EPA Method 8270C ZB-5MSi
GC Application #16413: EPA Method 8270C ZB-5MSi. Column used: Zebron™ ZB-5MSi, GC Cap. Column 30 m x 0.25 mm x 0.25 µm, Ea Part#: 7HG-G018-11
more infohttps://www.phenomenex.com/Application/Detail/16413
IDEALS @ Illinois: The mutation spectra of 4-nitroquinoline N-oxide-induced frameshift reversion ofhis4-38 in REV1 and rev1-1...  IDEALS @ Illinois: The mutation spectra of 4-nitroquinoline N-oxide-induced frameshift reversion ofhis4-38 in REV1 and rev1-1...
Of these 86 of the XY729 revertants and 94 of the XY760 revertants were due to $-$1 frameshift events, with the rest of the ... The mutation spectra of 4-nitroquinoline N-oxide-induced frameshift reversion ofhis4-38 in REV1 and rev1-1 strains of ... The mutation spectra of 4-nitroquinoline N-oxide-induced frameshift reversion ofhis4-38 in REV1 and rev1-1 strains of ... The mutation spectra of 4-nitroquinoline N-oxide-induced frameshift reversion ofhis4-38 in REV1 and rev1-1 strains of ...
more infohttps://www.ideals.illinois.edu/handle/2142/19784
HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling  HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling
Figure 4 Tid1 reduces the protein level of Galectin-7 by promoting ubiquitination, and the ubiquitination of Galectin-7 is ... Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha. Cancer Res. ... Figure 1 Predictive survival of HNSCC patients based on the expression profile of Tid1 and Galectin-7. (A) Immunohistochemical ... N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death. J Biol Chem. 2010;285:2232-44 ...
more infohttp://www.thno.org/v08p3841.htm
JCI -
Involvement of activation-induced cytidine deaminase in skin cancer development  JCI - Involvement of activation-induced cytidine deaminase in skin cancer development
Taichiro Nonaka,1,2 Yoshinobu Toda,3 Hiroshi Hiai,4 Munehiro Uemura,1 Motonobu Nakamura,5 Norio Yamamoto,6 Ryo Asato,6 Yukari ... Figure 4. Molecular characterization of spontaneous SCC in K14-AID-Tg mice. (A) Codon distribution of Hras1 somatic mutations. ... The top 4 codon numbers of mutations in human skin SCC are shown. (D) Base substitution patterns and frequency of the ... 25 and Supplemental Tables 3 and 4). The AID mutation signature is considered a C-to-T transition preceded by G or A (26), ...
more infohttps://www.jci.org/articles/view/81522
Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by...  Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by...
Kondo T1, Mihara K, Inoue Y, Namba M.. Author information. 1. Department of Cell Biology, Okayama University Medical School, ... we established three immortalized human fibroblast cell lines by treatment with either 4-nitroquinoline 1-oxide (4NQO) or 60Co ... on down-regulated intracellular transferrin in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8957196?dopt=Abstract
Fitness of CFT073 dinB yafP operon mutants. (A and B) S | Open-i  Fitness of CFT073 dinB yafP operon mutants. (A and B) S | Open-i
Similarly, YafP increased cytotoxicity of two DNA damaging nitroaromatic compounds, 4-nitroquinoline-1-oxide (NQO) and ... Similarly, YafP increased cytotoxicity of two DNA damaging nitroaromatic compounds, 4-nitroquinoline-1-oxide (NQO) and ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3105422_gkr050f3&req=4
Milk Thistle (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI] | HealthLink...  Milk Thistle (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI] | HealthLink...
Ten randomized trials [1,5,6,7,8,9,10,11,12,13] have been reported in patients with hepatitis or cirrhosis, and one randomized ... J Hepatol 9 (1): 105-13, 1989.. * Lucena MI, Andrade RJ, de la Cruz JP, et al.: Effects of silymarin MZ-80 on oxidative stress ... Call 9-1-1 or the local emergency number immediately. If you are concerned about a possible poisoning or exposure to a toxic ... The effects of silymarin and/or silybin have been investigated in prostate (DU 145, LNCaP, PC-3),[1,2,3,4,5,6]breast (MDA-MB ...
more infohttps://www.healthlinkbc.ca/health-topics/ncicdr0000347008
Genetic controls of susceptibility and resistance to 4-nitroqu...  Genetic controls of susceptibility and resistance to 4-nitroqu...
Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.: We analyzed ... Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.. Authors * ... 4-nitroquinoline 1-oxide solution for 180 days. The study included various crosses of susceptible Dark-Agouti rats (DA) and ... while WF showed only a 4% incidence. Reciprocal F1 and F2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, ...
more infohttps://www.mysciencework.com/publication/show/genetic-controls-susceptibility-resistance-4-nitroquinoline-1-oxide-induced-tongue-carcinomas-rats-1d21394f
DDR48 - Stress protein DDR48 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - DDR48 gene & protein  DDR48 - Stress protein DDR48 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - DDR48 gene & protein
1. 8. ,p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or ... 4. 8. ,p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or ... 1. ,p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding ,a ... 1. ,p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding ,a ...
more infohttp://www.uniprot.org/uniprot/P18899
Cartea Textbook of Biochemistry with Clinical Correlations: Thomas M. Devlin · 9780470281734 | Books Express  Cartea Textbook of Biochemistry with Clinical Correlations: Thomas M. Devlin · 9780470281734 | Books Express
Chapter 11 The Cytochromes P450 and Nitric Oxide Synthases (Linda J. Roman and Bettie Sue Siler Masters).. Chapter 12 ... PART I STRUCTURE OF MACROMOLECULES. Chapter 1 Eukaryotic Cell Structure (Thomas M. Devlin).. Chapter 2 DNA and RNA: Composition ... Chapter 4 DNA Replication, Recombination, and Repair (Howard J. Edenberg).. Chapter 5 RNA: Transcription and RNA Processing ( ... Handbook of Fuel Cells: Fundamentals, Technology, Applications, 4 Volume Set Wolf Vielstich ...
more infohttps://www.books-express.ro/textbook-of-biochemistry-with-clinical-correlations/p/psb,9780470281734
Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats...  Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats...
An adenocarcinoma (A, C, E, G) from a rat given DMAB alone (group 1) and that (B, D, F, H) from a rat given DMAB and 500 ppm ... The animals in groups 1 through 3 were given DMAB dissolved in DMSO, s.c., at a dose of 25 mg/kg body weight every other week ... DMAB injection was done between 10:00 a.m. and 11:00 a.m. From 1 week after the last injection of DMAB, group 1 was given the ... Prostate cancer is the most common type of cancer found in older men and the leading cause of cancer mortality in men (1). In ...
more infohttp://clincancerres.aacrjournals.org/content/11/13/4962
  • 5. Berks, B.C., Ferguson, S.J., Moir, J.W. and Richardson, D.J. Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions. (qmul.ac.uk)
  • More recently, silymarin has been reported to inhibit activation of erbB1 signaling, induce cyclin-dependent kinase inhibitors, G 1 arrest, and cause complete inhibition of growth of human prostate carcinoma DU145 cells ( 17 ). (aacrjournals.org)
  • To date, the cancer problem and the failure of conventional chemotherapy to achieve a reduction in the mortality rates for common epithelial malignancies such as carcinomas of the lung, colon, breast, prostate and pancreas, indicates a critical need for new approaches to control cancer development [ 1 , 2 ]. (mdpi.com)
  • Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats. (mysciencework.com)
  • We analyzed the incidence of infiltrative mass-type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4-nitroquinoline 1-oxide solution for 180 days. (mysciencework.com)
  • carcinomas occurred in the cheek pouch following implantation of wax pellets [ref: 1]. (inchem.org)
  • In hamsters, applications of such extracts to cheek-pouch mucosa produced squamous-cell carcinomas of the cheek pouch and forestomach carcinomas [ref: 1]. (inchem.org)
  • In hamsters, administration of areca nut and application of aqueous or dimethyl sulphoxide extracts to the cheek-pouch mucosa resulted in squamous-cell carcinomas of the cheek pouch and carcinomas of the forestomach [ref: 1]. (inchem.org)
  • 4-NQO was a potent mutagen in tongue, other pooled oral tissues and esophagus when given in drinking water for 4 weeks at a concentration of 20 microg/ml [corrected]. (nih.gov)
  • Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upp. (nih.gov)
  • Phospholipase C gamma 1 is a potential prognostic biomarker for patients with locally advanced and resectable oral squamous cell carcinoma. (semanticscholar.org)
  • 4 ] Humans exposed to this mushroom toxin develop serious liver failure that ultimately progresses to death. (healthlinkbc.ca)
  • Extracts of urine from chewers of betel quid with tobacco were mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system [ref: 4]. (inchem.org)
  • DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. (mysciencework.com)
  • Furthermore, migrant studies have shown that the incidence of prostate cancer increases generation by generation after immigration in Japanese-Americans ( 4 ). (aacrjournals.org)
  • Werner patient mutations truncate the WRN open reading frame and promote loss of the altered protein and both of its associated biochemical activities ( 4 , 28 , 42 ). (asm.org)
  • Of these 86 of the XY729 revertants and 94 of the XY760 revertants were due to $-$1 frameshift events, with the rest of the reversion events being due to complex mutations. (illinois.edu)
  • Under ionizing radiation the destruction of water molecules occurs in a human organism, giving rise to the formation of reactive oxygen intermediates (ROI) including hydroxyl- and superoxide-radicals [ 1 - 7 ]. (omicsonline.org)
  • Removal of thiols before treatment with 4-NQO resulted in increased production of 4-hydroxyaminoquinoline 1-oxide and increased production of nitro radicals. (aacrjournals.org)
  • They were then fed a diet containing 0.01% or 0.05% fenofibrate for 29 weeks, starting 1 week after 4-NQO administration. (mdpi.com)
  • It is known that the radiation factor can play a dominant role in the negative impact of the environment on human health [ 1 - 8 ]. (omicsonline.org)
  • 1 ] The active constituent of milk thistle is silymarin, which is a complex mixture of flavonoids and flavonoid derivatives, the flavonolignans. (healthlinkbc.ca)
  • They also received the experimental diet containing 100 or 500 ppm silymarin for 40 weeks, starting 1 week after the last dosing of DMAB. (aacrjournals.org)
  • In another case-control study of oral cancer, in which a clear effect of chewing betel with tobacco was found, no such effect was found for chewing betel without tobacco [ref: 1]. (inchem.org)