4-Nitrophenylphosphatase: An enzyme that catalyzes the hydrolysis of nitrophenyl phosphates to nitrophenols. At acid pH it is probably ACID PHOSPHATASE (EC 3.1.3.2); at alkaline pH it is probably ALKALINE PHOSPHATASE (EC 3.1.3.1). EC 3.1.3.41.Pichia: Yeast-like ascomycetous fungi of the family Saccharomycetaceae, order SACCHAROMYCETALES isolated from exuded tree sap.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Barth Syndrome: Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.Tripterygium: A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.Medication Adherence: Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.Mice, Inbred mdx: A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.Programming Languages: Specific languages used to prepare computer programs.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Templates, Genetic: Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.Civilization: The distinctly human attributes and attainments of a particular society.L-Aminoadipate-Semialdehyde Dehydrogenase: An enzyme that catalyzes the oxidation of L-2-aminoadipate 6-semialdehyde to L-2-aminoadipate (alpha-aminoadipic acid). It is involved in the biosynthetic pathway of LYSINE.Cysteine Synthase: An enzyme that catalyzes the biosynthesis of cysteine in microorganisms and plants from O-acetyl-L-serine and hydrogen sulfide. This enzyme was formerly listed as EC 4.2.99.8.Glutamate Dehydrogenase: An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.Amino Acids, Sulfur2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).Neurospora: A genus of ascomycetous fungi, family Sordariaceae, order SORDARIALES, comprising bread molds. They are capable of converting tryptophan to nicotinic acid and are used extensively in genetic and enzyme research. (Dorland, 27th ed)Neurospora crassa: A species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.NitrophenolsOrganophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Salts: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)Potassium Compounds: Inorganic compounds that contain potassium as an integral part of the molecule.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Alkanesulfonic Acids: Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Caenorhabditis elegans: A species of nematode that is widely used in biological, biochemical, and genetic studies.Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Nervous System Neoplasms: Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Hydroxymethylglutaryl CoA Reductases: Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Corpora Allata: Paired or fused ganglion-like bodies in the head of insects. The bodies secrete hormones important in the regulation of metamorphosis and the development of some adult tissues.Wharton Jelly: Jelly-like connective tissue of the UMBILICAL CORD that contains MESENCHYMAL STROMAL CELLS.Umbilical Cord: The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Multipotent Stem Cells: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Tissue Therapy, Historical: Historically, tissue transplantation, especially of refrigerated tissue (after Filatov). It was theorized that nonspecific substances, capable of initiating restorative processes, formed in tissues when refrigerated. Cell therapy (after Niehans) refers to implantation of tissue by injection. Originally this involved fresh cells but later frozen or lyophilized cells.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.Sodium-Potassium-Exchanging ATPase: An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.Kidney Medulla: The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Streptomycetaceae: A family of soil bacteria. It also includes some parasitic forms.Sodium, Dietary: Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.

Hyperaldosteronemia in rabbits inhibits the cardiac sarcolemmal Na(+)-K(+) pump. (1/86)

Aldosterone upregulates the Na(+)-K(+) pump in kidney and colon, classical target organs for the hormone. An effect on pump function in the heart is not firmly established. Because the myocardium contains mineralocorticoid receptors, we examined whether aldosterone has an effect on Na(+)-K(+) pump function in cardiac myocytes. Myocytes were isolated from rabbits given aldosterone via osmotic minipumps and from controls. Electrogenic Na(+)-K(+) pump current, arising from the 3:2 Na(+):K(+) exchange ratio, was measured in single myocytes using the whole-cell patch clamp technique. Treatment with aldosterone induced a decrease in pump current measured when myocytes were dialyzed with patch pipette solution containing Na(+) in a concentration of 10 mmol/L, whereas there was no effect measured when the solution contained 80 mmol/L Na(+). Aldosterone had no effect on myocardial Na(+)-K(+) pump concentration evaluated by vanadate-facilitated [(3)H]ouabain binding or by K(+)-dependent paranitrophenylphosphatase activity in crude homogenates. Aldosterone induced an increase in intracellular Na(+) activity. The aldosterone-induced decrease in pump current and increased intracellular Na(+) were prevented by cotreatment with the mineralocorticoid receptor antagonist spironolactone. Our results indicate that hyperaldosteronemia decreases the apparent Na(+) affinity of the Na(+)-K(+) pump, whereas it has no effect on maximal pump capacity.  (+info)

Alphabeta protomers of Na+,K+-ATPase from microsomes of duck salt gland are mostly monomeric: formation of higher oligomers does not modify molecular activity. (2/86)

The distance that separates alphabeta protomers of the Na(+), K(+)-ATPase in microsomes and in purified membranes prepared from duck nasal salt glands was estimated by measuring fluorescence resonance energy transfer between anthroylouabain bound to a population of alphabeta protomers and either N-[7-nitrobenz-2-oxa-1, 3-diazol-4-yl]-6-aminohexyl ouabain or 5-(and-6)-carboxyfluorescein-6-aminohexyl ouabain bound to the rest. Energy transfer between probes bound in the microsomal preparation was less than in the purified membranes. The efficiency of energy transfer between anthroylouabain and N-[7-nitrobenz-2-oxa-1, 3-diazol-4-yl]-6-aminohexyl ouabain was 29.2% in the microsomes compared with 62.6% in the purified preparation. Similar results were obtained with 5-(and-6)-carboxyfluorescein-6-aminohexyl ouabain as acceptor. We calculate that either the protomer bound probes were on the average 13 A farther apart in the microsomes than in the purified membranes, or that 53% of the protomers are monomeric in the microsome preparation. Microsomes prepared in the presence of phalloidin (a toxin that binds to F actin and stabilizes the actin-based cytoskeleton) showed less quench than those prepared in its absence. The data support the hypothesis that protomers are kept apart by their association with the cytoskeleton. The turnover rate while hydrolyzing ATP is the same in the microsomal and purified preparations; higher oligomer formation has no significant effect on the enzyme reaction mechanism.  (+info)

HMG CoA reductase inhibition reduces sarcolemmal Na(+)-K(+) pump density. (3/86)

OBJECTIVES: HMG CoA reductase inhibitors reduce cellular availability of mevalonate, a precursor in cholesterol synthesis. Since the cholesterol content of cell membranes is an important determinant of Na(+)-K(+) pump function we speculated that treatment with HMG CoA reductase inhibitors affects Na(+)-K(+) pump activity. METHODS: We treated rabbits and rats for 2 weeks with the HMG CoA reductase inhibitor lovastatin and measured Na(+)-K(+) pump current (I(p)) in isolated rabbit cardiac myocytes using the whole cell patch-clamp technique, K-dependent p-nitrophenyl phosphatase (p-NPPase) activity in crude myocardial and skeletal muscle homogenates, and vanadate-facilitated 3H-ouabain binding in intact skeletal muscle samples from rats. RESULTS: Treatment with lovastatin caused statistically significant reductions in I(p), myocardial and skeletal muscle K-dependent p-NPPase activity and 3H-ouabain binding in the myocardium and skeletal muscle. The lovastatin-induced decrease in I(p) was eliminated by parenteral co-administration of mevalonate. However, this was not related to cardiac cholesterol content. CONCLUSIONS: Treatment with lovastatin reduces Na(+)-K(+) pump activity and abundance in rabbit and rat sarcolemma.  (+info)

Structural and immunological similarities between high molecular weight zinc ion-dependent p-nitrophenylphosphatase and fructose-1,6-bisphosphate aldolase from bovine liver. (4/86)

High molecular weight zinc ion-dependent acid p-nitrophenylphosphatase (HMW-ZnAPase) was purified from bovine liver to homogeneity as judged by native and sodium dodecyl sulfate polyacrylamide gel electrophoresis. The partial sequence of the purified enzyme electroblotted on PVDF membrane reveals a 95% sequence homology with human and bovine liver fructose-1,6-bisphosphate aldolase isozyme B (FALD B). FALD B was isolated from bovine liver using an affinity elution from phosphocellulose column. FALD B from bovine liver shows a native and subunit molecular weight that is indistinguishable from that of HMW-ZnAPase. In addition, an affinity purified antiserum raised in rabbits against purified HMW-ZnAPase cross-reacts with bovine liver FALD B and rabbit muscle isozymes. Despite these similarities, HMW-ZnAPase does not show FALD activity and bovine liver FALD does not display any zinc ion-p-nitrophenylphosphatase activity. These results suggested the existence of structural and immunological similarities between bovine liver HMW-ZnAPase and FALD B. Differences in some amino acid residues in enzyme activity indicate that they may be involved in different biochemical functions.  (+info)

p-Nitrophenylphosphatase activity catalyzed by plasma membrane (Ca(2+) + Mg(2+)ATPase: correlation with structural changes modulated by glycerol and Ca(2+). (5/86)

The plasma membrane (Ca(2+) + Mg(2+))ATPase hydrolyzes pseudo-substrates such as p-nitrophenylphosphate. Except when calmodulin is present, Ca(2+) ions inhibit the p-nitrophenylphosphatase activity. In this report it is shown that, in the presence of glycerol, Ca(2+) strongly stimulates phosphatase activity in a dose-dependent manner. The glycerol- and Ca(2+)-induced increase in activity is correlated with modifications in the spectral center of mass (average emission wavenumber) of the intrinsic fluorescence of the enzyme. It is concluded that the synergistic effect of glycerol and Ca(2+) is related to opposite long-term hydration effects on the substrate binding domain and the Ca(2+) binding domain.  (+info)

Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13. (6/86)

p34, a specific p-nitrophenyl phosphatase (pNPPase) was identified and purified from the murine cell line EL4 in a screen for the intracellular molecular targets of the antiinflammatory natural product parthenolide. A BLAST search analysis revealed that it has a high degree of sequence similarity to two yeast alkaline phosphatases. We have cloned, sequenced, and expressed p34 as a GST-tagged fusion protein in Escherichia coli and an EE-epitope-tagged fusion protein in mammalian cells. Using p-nitrophenyl phosphate (pNPP) as a substrate, p34 is optimally active at pH 7.6 with a K(m) of 1.36 mM and K(cat) of 0.052 min(-1). Addition of 1 mM Mg(2+) to the reaction mixture increases its activity by 14-fold. Other divalent metal ions such as Co(2+) and Mn(2+) also stimulated the activity of the enzyme, while Zn(2+), Fe(2+), and Cu(2+) had no effect. Furthermore, both NaCl and KCl enhanced the activity of the enzyme, having maximal effect at 50 and 75 mM, respectively. The enzyme is inhibited by sodium orthovanadate but not by sodium fluoride or okadaic acid. Mutational analysis data suggest that p34 belongs to the group of phosphatases characterized by the sequence motif DXDX(T/V).  (+info)

Transepithelial potential in mesonephric nephrons of 7-day-old chick embryos in relation to the histochemically detected sodium pump. (7/86)

In order to obtain basic information on the transport properties of differentiating embryonic nephrons, we examined the 7-day-old chick mesonephros by measuring the transtubular epithelial potential difference (TPD) and by histochemical detection of Na,K-ATPase activity. TPD as an indicator of the electrogenic transport was measured in individual segments of superficial nephrons in vivo. Their electric polarity was always lumen-negative. TPD was reduced by addition of 10 mM KCN applied to the mesonephric nephrons from the outside. In the proximal tubules, TPD was significantly lower (mean+/-SD: -1.0+/-0.5 mV) than in the distal and collecting tubules (-2.2+/-1.0 mV, p< or =0.05). Activity of the sodium pump was evaluated histochemically by detection of ouabain-sensitive potassium-dependent p-nitrophenyl phosphatase in cryostat sections of the mesonephros. The enzyme activity was demonstrated only in distal tubules and in the collecting ducts, but not in the proximal tubules. These findings have revealed significant differences between embryonic nephron segments: the distal tubule, in contrast to the proximal one, is supplied by the sodium pump and is able to generate higher TPD. Therefore, we consider that it is only the distal nephron, which possesses the ability of active transport.  (+info)

Cytochemistry of protein kinase C and Na-K-ATPase in rabbit ciliary processes treated with phorbol ester. (8/86)

Immunocytochemical localization of protein kinase C (PKC) in rabbit ciliary processes was investigated using anti-PKC monoclonal antibodies (MAbs) against rabbit Types 1, 2, and 3 PKC. Specific immunolabeling was observed in nonpigmented epithelial (NPE) cells and in the capillaries of the ciliary processes with anti-Types 2 and 3 MAbs. No apparent staining was seen with anti-Type 1 MAbs. Immunoelectron microscopy of Types 2 and 3 MAbs revealed a diffuse distribution of immunoreactive PKC in the cytoplasm, in the nucleus, and on the plasma membrane in the NPE cells. When incubated with phorbol 12-myristate 13-acetate (PMA), the distribution of PKC was basically similar to that of the untreated group. However, the labelling density on the plasma membrane at basolateral interdigitation increased considerably for anti-Types 2 and 3 PKC MAbs. In addition, the enzyme cytochemical activity of Na-K-ATPase (ouabain-sensitive K-NPPase) and its change after PMA administration in the ciliary processes were observed. An intense reaction was seen on the basolateral plasma membrane of the NPE cells. In the PMA-treated group, the enzyme activity of Na-K-ATPase apparently was decreased. These findings provide evidence that PKC plays a crucial role in the function of the NPE cells of the ciliary processes, possibly in aqueous humor production.  (+info)

1. These experiments examined the effects of a high NaCl diet on (Na+, K+)-ATPase in kidney, heart and cerebral cortex, on the level of circulating inhibitor of (Na+, K+)-ATPase in plasma, and on stimulation of (Na+, K+)-ATPase by treatment with dextro (d)-amphetamine.. 2. High salt diet increased indices of (Na+, K+)-ATPase activity (K+-activated p-nitrophenylphosphatase activity and ouabain binding) in kidney medulla, prevented stimulation by amphetamine in cerebral cortex and reduced amphetamine stimulation in heart.. 3. High NaCl feeding increased the plasma level of circulating inhibitor of (Na+, K+)-ATPase.. 4. Amphetamine alone had no effect on inhibitor level but amphetamine administration reduced the increase in inhibitor with high NaCl feeding.. ...
The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. NIPSNAP2, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumors. While NIPSNAP3B is highly expressed skeletal muscle, NIPSNAP3A mRNA levels are low. NIPSNAP3A protein is associated with plasma membrane and partially localized in rafts. NIPSNAP proteins have been suggested to be important in vesicular transport. At least two isoforms of NIPSNAP3A are known to exist. NIPSNAP3A antibody is predicted to not cross-react with any other members of the NIPSNAP protein family. ...
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1. Homogenates were prepared from sphaeroplasts of aerobically grown glucose-de-repressed Saccharomyces carlsbergensis and the distributions of marker enzymes were investigated after differential centrifugation. Cytochrome c oxidase and cytochrome c were sedimented almost completely at 105g-min, and this fraction also contained 37% of the catalase, 27% of the acid p-nitrophenyl phosphatase, 53 and 54% respectively of the NADH- and NADPH-cytochrome c oxidoreductases. 2. Zonal centrifugation indicated complex density distributions of the sedimentable portions of these enzymes and of adenosine triphosphatases and suggested the presence of two mitochondrial populations, as well as a bimodal distribution of peroxisomes and heterogeneity of the acid p-nitrophenyl phosphatase-containing particles. 3. Several different adenosine triphosphatases were distinguished in a post-mitochondrial supernatant that contained no mitochondrial fragments; these enzymes varied in their sensitivities to oligomycin and ...
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BioAssay record AID 88393 submitted by ChEMBL: In vitro inhibition of Hematopoietic protein-tyrosine phosphatase using p-nitrophenyl phosphate as substrate..
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Quite right, Donnachadh. And in those days everyone smelt like a decomposing kipper and I doubt very much if LOreal shifted a whole lot of product either. Why do these soap-dodging greenies want to take us back to being neanderthal cave dwellers? I wonder if they really fancy the whole authentic experience. How about a world with no antibiotics or anaesthetics? There you are, in your cave, nibbling on an old bit of tofu, shivering in the freezing cold and youve got a raging toothache and a streptococcal infection that could scare the shit out of vancomycin. As you lay there in absolute agony, all you can smell is the fetid armpits of Ugg sat next to you. Is that the sort of world these people really want us to live in? It cant be long before they call for mandatory limits on the number of showers we can take ...
Distinguish between (i) Peptic and oxyntic cells (ii) Lipases and peptidases (///) Villi and microvilli (iv) Sucrose and maltose (v) Extracellular and intracellular digestion.
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Researchers at the Stanford Human Genome Center have developed a powerful new computer program that can map thousands of genetic markers at once. Using this program, called Mapper, scientists have obtained one of the most accurate views yet of the humangenome as a whole.
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ENDOTOXINE (TOXIKOLOGIE); BACILLUS THURINGIENSIS (MIKROBIOLOGIE); IN-VITRO UNTERSUCHUNGEN (TOXIKOLOGIE); ENDOTOXINS (TOXICOLOGY); BACILLUS THURINGIENSIS (MICROBIOLOGY); IN VITRO STUDIES (TOXICOLOGY ...
They fused the sequence for Bt toxin Cry1Ac with that of the nontoxic B-chain subunit of ricin (RB) in a recombinant plasmid. RB is a leptin that binds with galactose as well as N-acetylgalactosamine residues with high affinity, the latter of which are key components of Bt toxin-binding receptors. Then embryonic callus from mature maize seeds were bombarded with this BtRB fusion. The researchers tested their fusion toxin against stem borer Chilo suppressalis, a pest normally susceptible to Cry1Ac, and found that maize producing low levels of BtRB killed 75 per cent of larvae, compared with 17 per cent in Bt-only plants. Similar trials with the cotton leaf worm Spodoptera littoralis, which is resistant to Bt delta endotoxins, showed that after 4 days, nearly 78 per cent of larvae died on BtRB maize, compared with less than 20 per cent on Bt-only or nontransformed maize. In the leafhopper Cicadulina mbila, which like other homopterans was ordinarily not affected by Bt toxins, 95 per cent of ...
Bullfrog tadpole stomachs of various metamorphic stages were examined to determine the fine-structural development of oxyntic cells and to correlate observed morphological development with the capacity to secrete HCl. It was found that in vitro tadpole stomachs can consistently be stimulated to secrete acid by stage XXIV of metamorphosis, when tail reabsorption is nearly complete. Concomitant with the appearance of HCl secretion, identifiable oxyntic cells were found in the gastric glands.. Prior to stage XXIV (stages XXI and XXII) the majority of cells present in the developing gastric glands exhibit features of cytological organization characteristic of undifferentiated cells: large nuclei, relatively scantry cytoplasm, and numerous ribosomal particles within the cytoplasmic matrix. The newly differentiated oxyntic cells of stage XXIV tadpole stomachs are recognizable by the accumulation of tubular members of the smooth-surfaced endoplasmic reticulum in the apical portion of the cells. These ...
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AP is purified from calf intestine by affinity chromatography. AP is an important label in enzyme immuno assays for substrates like pNPP and BCIP
Thioglycosides have proved to be useful, enzymatically stable analogs of glycosides for structural and mechanistic studies and their synthesis is considerably simplified through the use of thioglycoligases. As part of an investigation into the use of thioglycosides as potential pharmacological chaperones, and as components of glycoproteins and glycolipids, the syntheses of p-nitrophenyl 3-thio-β-D-galactopyranoside, phenyl 1,4-dithio-β-D-glucopyranoside, p-nitrophenyl 4-thio-β-D-mannopyranoside and p-nitrophenyl 2-acetamido-2-deoxy-4-thio-β-D-mannopyranoside are described.
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TY - JOUR. T1 - Cloning, Expression, and Catalytic Mechanism of the Low Molecular Weight Phosphotyrosyl Protein Phosphatase from Bovine Heart. AU - Wo, Yu Yuan P.. AU - Zhou, Ming Ming. AU - Stevis, Panayiotis. AU - Davis, June P.. AU - Zhang, Zhong Yin. AU - Van Etten, Robert L.. PY - 1992/2/1. Y1 - 1992/2/1. N2 - The first representative of a group of mammalian, low molecular weight phosphotyrosyl protein phosphatases was cloned, sequenced and expressed in Escherichia coli. Using a 61-mer oligonucleotide probe based on the amino acid sequence of the purified enzyme, several overlapping cDNA clones were isolated from a bovine heart cDNA library. A full-length clone was obtained consisting of a 27-bp 5ʹ3ʹ noncoding region, an open reading frame encoding the expected 157 amino acid protein, and an extensive 3 nontranslated sequence. The identification of the clone as full length was consistent with results obtained in mRNA blotting experiments using poly(A)+ mRNA from bovine heart. The coding ...
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... map kinase kinase 4 MeSH D08.811.913.696.620.682.700.565.500 --- map kinase kinase 5 MeSH D08.811.913.696.620.682.700.565.600 ... map kinase kinase 4 MeSH D08.811.913.696.620.682.725.200.500 --- map kinase kinase 5 MeSH D08.811.913.696.620.682.725.200.600 ... type 4 MeSH D08.811.913.696.620.682.725.400.050 --- proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- ... 4-beta-glucosidase MeSH D08.811.277.450.420.200.600 --- glucan endo-1,3-beta-d-glucosidase MeSH D08.811.277.450.420.375 --- ...
EC 3.2.1.91: cellulose 1,4-b-cellobiosidase EC 3.2.1.92: peptidoglycan b-N-acetylmuramidase EC 3.2.1.93: a,a-phosphotrehalase ... 4-b-xylosidase EC 3.2.1.38: b-D-fucosidase EC 3.2.1.39: glucan endo-1,3-b-D-glucosidase EC 3.2.1.40: a-L-rhamnosidase EC 3.2. ... 4-a-glucosidase EC 3.2.1.4: cellulase EC 3.2.1.5: deleted EC 3.2.1.6: endo-1,3(4)-b-glucanase EC 3.2.1.7: inulinase EC 3.2.1.8 ... 4-b-xylanase EC 3.2.1.137: mannan exo-1,2-1,6-a-mannosidase EC 3.2.1.138: now EC 4.2.2.15 EC 3.2.1.139: Alpha-glucuronidase EC ...
Other names in common use include nitrophenyl phosphatase, p-nitrophenylphosphatase, para-nitrophenyl phosphatase, K-pNPPase, ... Attias J, Bonnet JL (1972). "A specific alkaline p-nitrophenylphosphatase activity from baker's yeast". Biochim. Biophys. Acta ... Attias J, Durand H (1973). "Further characterization of a specific p-nitrophenylphosphatase from baker's yeast". Biochim. ... NPPase, PNPPase, Ecto-p-nitrophenyl phosphatase, and p-nitrophenylphosphate phosphohydrolase. This enzyme participates in gamma ...
In this procedure alkaline phosphatase activity was also measured by p-nitrophenyl phosphatase (p-NPP) substrate reactions ... 2006, 4 (6): 8-View ArticleGoogle Scholar. *. Koch TG, Heerkens T, Thomsen PD, Betts DH: Isolation of mesenchymal stem cells ... 10.1007/s12015-010-9196-4.View ArticleGoogle Scholar. *. Carlin R, Davis D, Weiss M, Schultz B, Troyer D: Expression of early ... 2010, 3 (4): 248-69.Google Scholar. *. Francese R, Fiorina P: Immunological and regenerative properties of cord blood stem ...
Other names in common use include nitrophenyl phosphatase, p-nitrophenylphosphatase, para-nitrophenyl phosphatase, K-pNPPase, ... Attias J, Bonnet JL (1972). "A specific alkaline p-nitrophenylphosphatase activity from bakers yeast". Biochim. Biophys. Acta ... Attias J, Durand H (1973). "Further characterization of a specific p-nitrophenylphosphatase from bakers yeast". Biochim. ... NPPase, PNPPase, Ecto-p-nitrophenyl phosphatase, and p-nitrophenylphosphate phosphohydrolase. This enzyme participates in gamma ...
4-nitrophenylphosphatase. An enzyme that catalyzes the hydrolysis of nitrophenyl phosphates to nitrophenols. At acid pH it is ...
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate ... 5775 PTPN4; protein tyrosine phosphatase non-receptor type 4 5780 PTPN9; protein tyrosine phosphatase non-receptor type 9 26095 ... 2070 EYA4; EYA transcriptional coactivator and phosphatase 4 84867 PTPN5; protein tyrosine phosphatase non-receptor type 5 5778 ... 1846 DUSP4; dual specificity phosphatase 4 1844 DUSP2; dual specificity phosphatase 2 1849 DUSP7; dual specificity phosphatase ...
... 26 4-phytase. EC 3.1.3.27 phosphatidylglycerophosphatase. EC 3.1.3.28 ADPphosphoglycerate phosphatase. EC 3.1.3.29 N- ... EC 3.1.3.40 guanidinodeoxy-scyllo-inositol-4-phosphatase. EC 3.1.3.41 4-nitrophenylphosphatase. EC 3.1.3.42 [glycogen-synthase- ... EC 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. EC 3.1.3.68 2-deoxyglucose-6-phosphatase. EC 3.1.3.69 ... EC 3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase. EC 3.1.3.58 sugar-terminal-phosphatase. EC 3.1.3.59 ...
Proteinase K cleavage.Pig kidney membranes were incubated in 25/or 1 mM ADP, as indicated. The samples were treated with PK (PK/protein ratio ∼1∶50) and the
Effect of temperature, pH, and vanadate sensitivity of the CPZ treated enzyme.A. Pig kidney Na+,K+-ATPase activity was measured at four different temperatures,
EC 3.1.4: Phosphoric Diester Hydrolases. * EC 3.1.4.1: phosphodiesterase I * EC 3.1.4.2: glycerophosphocholine ... EC 3.1.3.66: phosphatidylinositol-3,4-bisphosphate 4-phosphatase * EC 3.1.3.67: phosphatidylinositol-3,4,5-trisphosphate 3- ... EC 3.2.1.141: [[4-a-D-((1(arrow to right)4)-a-D-glucano}trehalose trehalohydrolase]] ... EC 3.1.1.66: 5-(3,4-diacetoxybut-1-ynyl)-2,2-bithiophene deacetylase ...
cfi:Celf_0823 PHP domain protein K04477 240 110 ( 7) 31 0.321 112 -, 4 cro:ROD_25061 N-acetylmuramic acid 6-phosphate etherase ... aly:ARALYDRAFT_475563 large subunit of riblose-1,5-bisp K01601 479 375 ( 0) 91 0.266 410 -, 4 apak:AP3564_01620 2,3-diketo-5- ... srw:TUE45_02259 putative hydrolase YutF 342 122 ( 4) 34 0.318 195 -, 6 cfl:Cfla_2467 UBA/THIF-type NAD/FAD binding protein 497 ... psos:POS17_0309 dTDP-4-dehydrorhamnose reductase K00067 293 106 ( 3) 30 0.325 83 -, 2 saq:Sare_3653 aldo/keto reductase K05275 ...
4-nitrophenylphosphatase activity; ATP binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative ...
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate ...
... map kinase kinase 4 MeSH D08.811.913.696.620.682.700.565.500 --- map kinase kinase 5 MeSH D08.811.913.696.620.682.700.565.600 ... map kinase kinase 4 MeSH D08.811.913.696.620.682.725.200.500 --- map kinase kinase 5 MeSH D08.811.913.696.620.682.725.200.600 ... type 4 MeSH D08.811.913.696.620.682.725.400.050 --- proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- ... 4-beta-glucosidase MeSH D08.811.277.450.420.200.600 --- glucan endo-1,3-beta-d-glucosidase MeSH D08.811.277.450.420.375 --- ...
EC 3.2.1.91: cellulose 1,4-b-cellobiosidase EC 3.2.1.92: peptidoglycan b-N-acetylmuramidase EC 3.2.1.93: a,a-phosphotrehalase ... 4-b-xylosidase EC 3.2.1.38: b-D-fucosidase EC 3.2.1.39: glucan endo-1,3-b-D-glucosidase EC 3.2.1.40: a-L-rhamnosidase EC 3.2. ... 4-a-glucosidase EC 3.2.1.4: cellulase EC 3.2.1.5: deleted EC 3.2.1.6: endo-1,3(4)-b-glucanase EC 3.2.1.7: inulinase EC 3.2.1.8 ... 4-b-xylanase EC 3.2.1.137: mannan exo-1,2-1,6-a-mannosidase EC 3.2.1.138: now EC 4.2.2.15 EC 3.2.1.139: Alpha-glucuronidase EC ...
4 /53. 9. 33. NM_030978. np4. np. np. 6. pH 4-7. 1.5. gi 4406577. Unknown, clone 24952. 19. 14. 5.2. 5.4. 7 /105. 14. 36. ... 4 /4. 14. 17. 25. pH 4-7. −7.89. gi 227920. Beta galactoside soluble lectin. 15. 7. 5.3. 5.0. 8 /12. 12. 54. LGALS1. J04456. − ... 4. Zoom-in region from the IPG strip pH 4-7 for T47D (upper) and T47D-r (lower). All protein spots that were found to be ... 4. pH 4-7. −2.9. gi 238470 gi 251370. Acid phosphatase isozyme Bf or Af. 18. 14. 7.1. 6.4. 12 /14. 14. 81. ACP1. U25849. 1.4. ...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V "We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
PFB0310c (MSP-4, MSP4) merozoite surface protein 4 *PFD1160w (SURFIN4.2, Surf4.2) surface-associated interspersed gene 4.2, ( ... PFD1120c (ETRAMP4, SEP4, Etramp 4, Etramp4) early transcribed membrane protein 4 *PF11_0302 (PV-1) parasitophorous vacuolar ... PFD1120c (ETRAMP4, SEP4, Etramp 4, Etramp4) early transcribed membrane protein 4 *PFD0310w (Pfs16) sexual stage-specific ... PFC0105w (SRPK1, CLK-4) serine/threonine protein kinase, putative *PFI0250c (Nup100) conserved Plasmodium membrane protein, ...
Caspase-4 3.4.22.58 Caspase-5 3.4.22.59 Caspase-6 3.4.22.60 Caspase-7 3.4.22.61 Caspase-8 3.4.22.62 Caspase-9 3.4.22.63 Caspase ... 4-alpha-glucosidase 3.2.1.4 Cellulase 3.2.1.5 Deleted entry 3.2.1.6 Endo-1,3(4)-beta-glucanase 3.2.1.7 Inulinase 3.2.1.8 Endo-1 ... 4-beta-xylanase 3.2.1.9 Deleted entry 3.2.1.10 Oligo-1,6-glucosidase 3.2.1.11 Dextranase 3.2.1.12 Transferred entry: 3.2.1.54 ... 4-beta-xylosidase 3.2.1.38 Beta-D-fucosidase 3.2.1.39 Glucan endo-1,3-beta-D-glucosidase 3.2.1.40 Alpha-L-rhamnosidase 3.2.1.41 ...
Shah RL, Li Q, Zhao W, Tedja MS, Tideman JWL, Khawaja AP, Fan Q, Yazar S, Williams KM, Verhoeven VJM, Xie J, Wang YX, Hess M, Nickels S, Lackner KJ, Pärssinen O, Wedenoja J, Biino G, Concas MP, Uitterlinden A, Rivadeneira F, Jaddoe VWV, Hysi PG, Sim X, Tan N, Tham YC, Sensaki S, Hofman A, Vingerling JR, Jonas JB, Mitchell P, Hammond CJ, Höhn R, Baird PN, Wong TY, Cheng CY, Teo YY, Mackey DA, Williams C, Saw SM, Klaver CCW, Guggenheim JA, Bailey-Wilson JE. A genome-wide association study of corneal astigmatism: The CREAM Consortium. Mol Vis. 2018; 24:127-142 ...
4. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard. ... Crystal structure of 4-nitrophenylphosphatase (TM1742) from Thermotoga maritima at 2.40 A resolution. To be published. ... The gene TM1742 from Thermotoga maritima encodes a 4-nitrophenylphosphatase EC:3.1.3.41. The enzyme was previously crystallized ... The enzyme catalyzes the hydrolysis of 4-nitrophenyl phosphate to form 4-nitrophenol. ...
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group). 0.193. ... pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2. 0.111. ... 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans). 0.028. ... solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4. 0.029. ...
4-lactone oxidase, involved in biosynthesis of D-erythroascorbic acid, which has a protective role against oxidative damage; ... 4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L- ... 3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hypha switch; macrophage interaction Inositol phosphoryl ... Gcn4p-regulatedProtein abundance is affected by URA3 expression in the CAI-4 strain background; alkaline upregulated; Gcn4p- ...
X-ray diffraction data for the Crystal structure of a putative monooxygenase (YP_001095275.1) from Shewanella loihica PV-4 at ... X-ray diffraction data for the Crystal structure of 4-nitrophenylphosphatase (TM1742) from Thermotoga maritima at 2.40 A ...
Boc Sciences offers cas 208651-58-5 4-Nitrophenyl phosphate potassium salt in bulk,please inquire us to get a quote for 208651- ... 2.Detection of ouabain-insensitive H(+)-transporting, K(+)-stimulated p-nitrophenylphosphatase activity in rat gastric glands ... K-stimulated p-nitrophenylphosphatase (K-pNPPase) activity in rat gastric glands. Biochemically, the enzyme activity of gastric ... K-dependent p-nitrophenylphosphatase (Na-K ATPase) activity to detect ouabain-insensitive, ...
Differential diagnoses, possible causes and diseases for Nitrophenyl, Phosphatase listed by probability for chosen ... The protein exhibited high esterase activity towards short chain esters like ethyl acetate and 4-nitrophenyl acetate.[ncbi.nlm. ... broblasts and the chromogenic substrate 2-hexadecanoylamino-4-nitrophenyl-b-D-glucopyranoside. Clin Chim Acta 120: 57-63.[link. ...
  • In enzymology, a 4-nitrophenylphosphatase (EC 3.1.3.41) is an enzyme that catalyzes the chemical reaction 4-nitrophenyl phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } 4-nitrophenol + phosphate Thus, the two substrates of this enzyme are 4-nitrophenyl phosphate and H2O, whereas its two products are 4-nitrophenol and phosphate. (wikipedia.org)
  • Using this principle, we constructed mesoporous structures on the surfaces of pure platinum electrodes responding even more sensitively to glucose than to common interfering species, such as L-ascorbic acid and 4-acetamidophenol. (biomedsearch.com)
  • A calmodulin kinase II inhibitor [(8)-5-isoquinolinesulfonic acid, 4-[2-(5-isoquinolinyl-sulfonyl)methylamino]-3-oxo-(4-phenyl-1-piperazinyl)-propyl]phenyl ester (KN-62)] decreased the pilocarpine-induced increase of AQP5 in the APM. (aspetjournals.org)
  • I. Properties and distribution of heat- and formaldehyde-stable liver acid p-nitrophenylphosphatase. (naver.com)
  • Changes in tissue and plasma heat- and formaldehyde-stable acid p-nitrophenylphosphatase. (naver.com)
  • M 3 mAChRs trigger similar signal transduction pathways that involve the heterotrimeric G protein Gq-mediated activation of phospholipase C (PLC) - β , which results in the generation of inositol 1,4,5-trisphosphate (IP 3 ) and 1,2-diacylglycerol (DAG). (aspetjournals.org)
  • 2.Detection of ouabain-insensitive H(+)-transporting, K(+)-stimulated p-nitrophenylphosphatase activity in rat gastric glands by cerium-based cytochemistry. (bocsci.com)
  • Separation of large lysosomal vacuoles which contained p -nitrophenylphosphatase activity was obtained and these were clearly resolved from mitochondria by both highspeed and rate zonal centrifugation. (microbiologyresearch.org)
  • 4-Nerolidylcatechol (4-NC) is found in Pothomorphe umbellata root extracts and is reported to have a topical protective effect against UVB radiation-induced skin damage, toxicity in melanoma cell lines, and antimalarial activity. (bvsalud.org)
  • We report a comparative study of the antioxidant activity of 4-NC and α-tocopherol against lipid peroxidation initiated by two free radical-generating systems: 2,2′-azobis(2-aminopropane) hydrochloride (AAPH) and FeSO4/H2O2, in red blood cell ghost membranes and in egg phosphatidylcholine (PC) vesicles. (bvsalud.org)
  • The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. (blogspot.com)
  • Zusätzlich bieten wir Ihnen 3-Oxoacid CoA Transferase 1 Proteine (9) und 3-Oxoacid CoA Transferase 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Mitochondria were sedimented quantitatively at 10 4 g -min and accounted for approximately 10% of the total recovered protein. (microbiologyresearch.org)
  • Pretreatment of rat parotid tissue with the NO scavenger 2-(4carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide potassium inhibited both acetylcholine (ACh)- and pilocarpine-induced increases in AQP5 in the APM. (aspetjournals.org)
  • 4. Amphetamine alone had no effect on inhibitor level but amphetamine administration reduced the increase in inhibitor with high NaCl feeding. (clinsci.org)
  • Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery. (mcmaster.ca)
  • Pretreatment of the tissues with a myosin light chain kinase inhibitor [(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9)] inhibited a mAChR-stimulated increase in AQP5 levels in the APM. (aspetjournals.org)
  • In egg PC vesicles, malondialdehyde formation indicated that 4-NC was effective against lipoperoxidation initiated by both AAPH and FeSO4/H2O2, whereas α-tocopherol was less efficient in protecting against lipoperoxidation by AAPH, and behaved as a pro-oxidant for FeSO4/H2O2. (bvsalud.org)
  • While cancer itself may cause anorexia ( 2 , 3 ), anorexia induced by chemotherapy is an independent aggravating problem, which mechanisms need to be better clarified ( 4 ). (frontiersin.org)
  • UBXD8 (显示 FAF2 ELISA试剂盒 ) is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain. (antibodies-online.cn)
  • The electron transfer system catalysing reduction of fumarate by NADH under anaerobic conditions in membrane preparations of Bacteroides ruminicola strain B 1 4 was inhibited by 2-n-heptyl-4-hydroxyquinoline N -oxide. (microbiologyresearch.org)
  • The DPPH (2,2-diphenyl-1-picrylhydrazyl) free-radical assay indicated that two free radicals were scavenged per 4-NC molecule, and one free radical was scavenged per α-tocopherol molecule. (bvsalud.org)
  • Reduction of b -type cytochrome by NADH under anaerobic conditions was much slower than reduction of fumarate by NADH, and was more sensitive to 2-n-heptyl-4-hydroxyquinoline N -oxide inhibition. (microbiologyresearch.org)
  • Extraction of quinone from the membrane and subsequent reincorporation showed that menaquinone (vitamin K 2 ) is an obligatory intermediate in the reduction of both fumarate and b -type cytochrome by NADH, which is consistent with the 2-n-heptyl-4-hydroxyquinoline N -oxide inhibition results. (microbiologyresearch.org)
  • Renal and vascular effects of C-type and atrial natriuretic peptides in humans," American Journal of Physiology-Regulatory Integrative and Comparative Physiology , vol. 273, no. 4, pp. (hindawi.com)
  • Official investigations had revealed that 1.3 % of adults in Guadeloupe were exposed above the "no effect threshold dose" (the reference dose RfD) of 0.5 μg/kg/d [ 4 ]. (biomedcentral.com)
  • Our pilot study aimed to determine the effect of gestational lifestyle counseling on the offspring weight gain until 4 year. (biomedcentral.com)
  • and, in this case, the protective effect of α-tocopherol was lower than that of 4-NC. (bvsalud.org)
  • These data provide new insights into the antioxidant capacity of 4-NC, which may have therapeutic applications for formulations designed to protect the skin from sunlight irradiation. (bvsalud.org)
  • Zoom-in region from the IPG strip pH 4-7 for T47D ( upper ) and T47D-r ( lower ). (mcponline.org)