Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
A white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide and used in organic syntheses. This should not be confused with benzoin gum from STYRAX.

Laboratory evaluation of WBA 8119 as a rodenticide for use against warfarin-resistant and non-resistant rats and mice. (1/71)

Feeding tests were carried out in the laboratory to evaluate WBA 8119 as a potential new rodenticide against wild common rats (Rattus norvegicus), ship rats (R. rattus) and house mice (Mus musculus). The results obtained are compared with data previously obtained for difenacoum, another member of the same series of 4-hydroxycoumarin anticoagulants. With warfarin-resistnat and non-resistant common rats, complete kills were obtained using a concentration of 0-0005% for 2 days, or 0-001% for 1 day: a 1-day test at 0-0005% killed 6 out of 10 and 17 out of 20 of the two types respectively. At 0-0005% complete kills of resistant ship rats were obtained after 2 days exposure and of resistant house mice after 1 day, but at 0-002% for 2 days there was some survival. Non-resistant ship rats and house mice were all killed after 2 days feeding on 0-002% bait. In 2-day palatability tests, R. norvegicus showed no significant aversion to the poison at 0-002% and 100% mortality was obtained. The poison was significantly unpalatable to R. rattus at 0-005% and to M. musculus at 0-005% and 0-002%, although with the last species these concentrations gave complete kills. It is concluded that WBA 8119 has greater activity than other known anticoagulants against the three commensal species examined. The laboratory results suggest that concentrations between 0-0005% and 0-002% would be suitable for field use against common rats, and between 0-002% and 0-005% for ship rats and house mice.  (+info)

Trials of the anticoagulant rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.). (2/71)

The efficacy of the newly developed anticoagulant rodenticide WBA 8119 was evaluated against the house mouse (Mus musculus L.) using individual and family groups of warfarin-resistant animals. WBA 8119 at 0-002%, 0-005% and 0-01% in pinhead oatmeal bait gave complete kills of mice in 'no-choice' feeding tests carried out in cages and small pens. In replicated 21-day treatments on families of mice confined in larger pens conditioned to feeding on plain foods, the overall mortalities obtained using the three formulated poison baits were 71/72, 62/63 and 57/57 respectively. The results of the WBA 8119 toxicity tests are considered in relation to previous findings on other anticoagulant rodenticides, particularly difenacoum. In equivalents tests, WBA 8119 performed better than difenacoum. The data thus suport the laboratory findings that WBA 8119 is the most active anticoagulant so far tested for the control of warfarin-resistant house mice.  (+info)

Methylation of 4-hydroxycoumarin with diazomethane. (3/71)

4-Hydroxycoumarin was methylated with diazomethane. A mixture of 4-methoxycoumarin and 2-methoxychromone was separated chromatographically.  (+info)

Determination of coumarin-type anticoagulants in human plasma by HPLC-electrospray ionization tandem mass spectrometry with an ion trap detector. (4/71)

BACKGROUND: Coumarin-type anticoagulants are used for the long-term treatment and prevention of thromboembolic disorders. The identification of these drugs is crucial in patients with an increased prothrombin time of unknown origin. The aim of this study was to develop a sensitive and specific method for the simultaneous determination of phenprocoumon, acenocoumarol, and warfarin in human plasma by HPLC-electrospray ionization tandem mass spectrometry. METHODS: After addition of the internal standard, p-chlorowarfarin, plasma samples were extracted using Oasis MCX solid-phase extraction cartridges. The compounds were separated on a Symmetry C18 column (Waters) with a mobile phase of acetonitrile-1 g/L formic acid (75:25 by volume) at a flow rate of 0.5 mL/min. RESULTS: Extraction and separation of the three drugs and the internal standard were accomplished in 9 min. The overall extraction efficiency was >89% for all three compounds. The limits of detection were 1 microg/L for phenprocoumon and warfarin and 10 microg/L for acenocoumarol. Regression analysis of the calibration data revealed good correlation (r(2) >or=0.995) for all compounds. Within-run accuracies for quality-control samples were +/- 1% to 7% of the target concentration, with CVs <9%. CONCLUSIONS: The proposed method enables the unambiguous identification and quantification of phenprocoumon, warfarin, and acenocoumarol in both clinical and forensic specimens. This method combines a new, rapid solid-phase extraction procedure with an extremely fast chromatographic analysis, which is especially advantageous for clinical laboratories.  (+info)

Acquired coagulopathy due to anticoagulant rodenticide poisoning. (5/71)

A 35-year-old woman was admitted to hospital because of epistaxis, hematomas, and metrorrhagia. Laboratory data indicated severe coagulopathy with prolonged prothrombin time and decreased serum concentrations of vitamin K-dependent clotting factors II, VII, IX, and X. The patient denied taking any oral anticoagulants. She was given transfusions of red blood cells, fresh frozen plasma (1,180 mL) and phytomenadione daily for 6 weeks (total dose 550 mg), which normalized the coagulation factors concentration. After all other possible causes of acquired coagulopathy had been excluded, rodenticide poisoning was suspected on the basis of her epidemiologic history. The patient was a war refugee from Bosnia and Herzegovina. During her absence, the troops of United Nations Protection Force performed rodent extermination in and around her house. History data and therapeutic effects suggested that the coagulopathy had been caused by prolonged exposure to long-acting anticoagulant rodenticide. This could also explain the need for protracted phytomenadione therapy.  (+info)

Brodifacoum toxicosis in two neonatal puppies. (6/71)

Eight out of a litter of 13 puppies were either born dead or died within 48 hours of birth. Three puppies that died shortly after birth were necropsied. Two puppies had hemorrhage in the thoracic and peritoneal cavities, intestinal serosa, and meninges. The third puppy was smaller than the other two puppies but did not have detectable hemorrhage. Brodifacoum, a second-generation coumarin anticoagulant, was detected in livers from the two puppies with hemorrhage. The dam did not have clinical signs of coagulopathy before or subsequent to whelping. The owners were confident that the dog had not been exposed to rodenticide for at least 4 weeks before whelping. A presumptive diagnosis of in utero brodifacoum toxicity was made. To the authors' knowledge this is the first time a second-generation coumarin anticoagulant has been detected in the liver of a newborn animal. This case is also unique because the dam was unaffected, suggesting that fetuses are more susceptible to brodifacoum toxicity than adult animals.  (+info)

Electrooxidation of iodide in the presence of 4-hydroxycoumarin: application to a simple coulometric titration of 4-hydroxycoumarin. (7/71)

The electrochemical oxidation of iodide ion in the presence of 4-hydroxycoumarin (1) was studied using cyclic voltammetry and controlled-potential coulometry. The result indicates that the resulting iodine takes part in a halogenation reaction and reacts with 4-hydroxycoumarin (1). According to the obtained results, a new and simple coulometric titration method with potentiometric end-point detection for the determination of 4-hydroxycoumarin (1) is presented. In the presented method, 2-200 micromol of 4-hydroxycoumarin (1) was successfully determined.  (+info)

A 44-year-old woman with hematemesis and cutaneous hemorrhages as a result of superwarfarin poisoning. (8/71)

The authors present the case of a 44-year-old American Indian woman with hematemesis, spontaneous cutaneous hemorrhages, and multiple ecchymoses. Coagulation factor analyses demonstrated both prolonged prothrombin time (PT, >40 s) and prolonged partial thromboplastin time (PTT, >120 s). Measurement of the serum level of brodifacoum (37 ng/mL), one of the superwarfarin agents commonly used in rodenticides, confirmed poisoning as the cause of the patient's symptoms. Substantial amounts of fresh frozen plasma and vitamin K were required to obtain normal coagulation parameters and maintain these parameters over a 3-week inhospital period. Oral administration of vitamin K (100 mg daily) maintained normal PT (14.1 s), PTT (33.0 s), and international normalized ratio (INR, 1.48) at 2 weeks after the patient was discharged from the hospital. By 2 months postdischarge, PT, PTT, and INR returned to elevated levels because of patient noncompliance with the prescribed tapering vitamin K regimen.  (+info)

4-Hydroxycoumarins are a class of organic compounds that are commonly used as anticoagulants, or blood thinners. They work by inhibiting the enzyme responsible for the synthesis of vitamin K, which is necessary for blood clotting. As a result, 4-hydroxycoumarins can prevent blood clots from forming, making them useful for treating conditions such as deep vein thrombosis, pulmonary embolism, and stroke. Some examples of 4-hydroxycoumarins include warfarin and phenprocoumon. It is important to note that 4-hydroxycoumarins can have serious side effects, including bleeding, and require careful monitoring by a healthcare professional.

Benzoin is a natural resin obtained from the stem of several species of trees in the Styrax genus, including Styrax benzoin and Styrax tonkinensis. It has a sweet, vanilla-like odor and is commonly used in perfumes, cosmetics, and pharmaceuticals. In the medical field, benzoin is used as a topical antiseptic and astringent. It is often applied to the skin to help prevent infection and to reduce inflammation and swelling. Benzoin is also used as a local anesthetic in dentistry and other medical procedures. Benzoin is generally considered safe when used as directed, but it can cause skin irritation or allergic reactions in some people. It should be avoided by people with certain medical conditions, such as diabetes or kidney disease, and by pregnant or breastfeeding women.

... are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a ... Although 4-hydroxycoumarin itself is not an anticoagulant, it is an important fungal metabolite from the precursor coumarin, ... 4-hydroxycoumarins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Synthesis (4-Hydroxycoumarins, ... The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not ...
Finally, enolate 4 abstracts a proton from protonated base (or solvent) to produce 5. The reaction is dominated by orbital, ... 4, p. 776 McMurry, J. E.; Melton, J. (1988). "Conversion of Nitro to Carbonyl by Ozonolysis of Nitronates: 2,5-Heptanedione". ... 4, p. 630 Moffett, R. B. (1963). "Methyl γ-Methyl-γ-nitrovalerate". Organic Syntheses.; Collective Volume, vol. 4, p. 652 ... The terms oxa-Michael reaction and aza-Michael reaction have been used to refer to the 1,4-addition of oxygen and nitrogen ...
also in the Collective Volume (1963) 4: 478 (PDF)). Jain, P. K.; Makrandi, J. K. (1982). "A Facile Baker-Venkataraman Synthesis ... Kalinin, A.V.; Sneckus, V. (1998). "4,6-Dimethoxy-3,7-dimethylcoumarin from Colchicum decaisnei. Total synthesis by carbamoyl ... Regiospecific route to substituted 4-hydroxycoumarins". Tetrahedron Letters. 39 (28): 4995-4998. doi:10.1016/S0040-4039(98) ...
East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of ...
East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of ...
4-hydroxycoumarins are a type of vitamin K antagonist. They block the regeneration and recycling of vitamin K. These chemicals ... Some of the 4-hydroxycoumarin anticoagulant class of chemicals are designed to have high potency and long residence times in ... 135 (4): 2157-2162. doi:10.1016/j.foodchem.2012.07.083. hdl:2158/775163. PMID 22980784. S2CID 14467019. Hatano, T.; et al. ( ... 37 (4): 423-453. doi:10.1016/S0278-6915(99)00010-1. PMID 10418958. "Frequently Asked Questions about coumarin in cinnamon and ...
The MK-4 form is from conversion of plant-sourced vitamin K1 in various tissues in the body. Because vitamin K aids mechanisms ... Animals may also convert it to vitamin K2, variant MK-4. Bacteria in the gut flora can also convert K1 into K2. All forms of K2 ... One subset, 4-hydroxycoumarins, act as vitamin K antagonists. They block the regeneration and recycling of vitamin K. Some of ... The two most studied ones are menaquinone-4 (MK-4) and menaquinone-7 (MK-7). Vitamin K1 is made by plants, and is found in ...
Section 3.1.4. Retrieved 21 June 2017. Sean C Sweetman, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London ... For a more complete list of coumarins used as pharmaceuticals and rodenticides, see the main article on 4-hydroxycoumarins. ... The vitamin K antagonists can cause birth defects (teratogens). Coumarins (more accurately 4-hydroxycoumarins) are the most ...
... is a coumarin derivative with a hydroxy group at the 4-position. 4-Hydroxycoumarin is an important fungal ... 4-Hydroxycoumarin is biosynthesized from malonyl-CoA and 2-hydroxybenzoyl-CoA by the enzyme 4-hydroxycoumarin synthase. After ... 4-Hydroxycoumarin forms the core of the chemical structure of anticoagulants known collectively as 4-hydroxycoumarins. They ... Liu, B.; Raeth, T.; Beuerle, T. & Beerhues, L. (2010). "A novel 4-hydroxycoumarin biosynthetic pathway". Plant Mol. Biol. 72 (1 ...
175 (4): 461-468. doi:10.1111/j.0954-6820.1964.tb00594.x. ISSN 0954-6820. PMID 14149651. Schäfer, F. P., ed. (1990). Dye Lasers ... 4-Phenylcoumarin is the backbone of the neoflavones, a type of neoflavonoids. Coumarin pyrazole hybrids have been synthesized ... 4 April 2019. Retrieved 13 April 2019. "Coumarins and indandiones". Drugs.com. 2016. Retrieved 24 December 2016. "Warfarin". ... This occurs as the result of the production of 4-hydroxycoumarin, then further (in the presence of naturally occurring ...
72 (4): 284-291. doi:10.1016/j.jjcc.2018.03.009. PMID 29706404. Holbrook AM, Pereira JA, Labiris R, McDonald H, Douketis JD, ... 58 (4): 395-401. doi:10.1016/j.jacc.2011.03.031. PMC 3175766. PMID 21757117. Delaney JA, Opatrny L, Brophy JM, Suissa S (August ... 177 (4): 369-371. doi:10.1503/cmaj.070946. PMC 1942100. PMID 17698826. Kurnik D, Loebstein R, Farfel Z, Ezra D, Halkin H, ... 193-4. ISBN 978-0-8493-7229-2. Retrieved on 15 December 2008 through Google Book Search. Loftus CM (1995). "Fetal toxicity of ...
4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 - epirizole MeSH D03.383.129.539.487 - ... 4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH D03.383.312.649.313 - furazolidone MeSH ... 4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.210 - dimethindene MeSH D03.383. ...
4-Hydroxycoumarins, All stub articles, Blood and blood forming organ drug stubs). ...
... , a 4-hydroxycoumarin structurally similar to warfarin, is a white to off-white crystalline powder with a ... Lovenox 4.000 IE (40 mg)/0,4 ml Injektionslösung in einer Fertigspritze. Entry on Phenprocoumon. at: Römpp Online. Georg Thieme ...
It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added ...
51 (4): 561-74. doi:10.1177/0091270010370588. PMID 20622200. S2CID 36344392. Albrecht D, Turakhia MP, Ries D, Marbury T, Smith ... 117 (4): 706-717. doi:10.1160/TH16-08-0623. PMID 28180234. S2CID 4356089. Spreitzer H (27 February 2017). "Neue Wirkstoffe - ... 4-Hydroxycoumarins, All stub articles, Blood and blood forming organ drug stubs). ...
... is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It has anticoagulant effects and is used ...
... is a 4-hydroxycoumarin anticoagulant, with a similar mode of action to its historical predecessors dicoumarol and ... 24 (2): 202-4. doi:10.1097/mbc.0b013e328358e959. PMID 23358203. La Rosa F; Clarke S; Lefkowitz J B (1997). "Brodifacoum ... In another case reported in 2013, a 48-year-old female patient reported 4 days of mild dyspnea, dry cough, bilateral popliteal ... Brodifacoum is a derivative of the 4-hydroxy-coumarin group. Compounds numbers are found next to their respective compounds in ...
... is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide. Coumatetralyl is ...
... is a fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a ...
Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin ... Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a ... and other 4-hydroxycoumarin drugs. It is given orally, and it acts within two days. Dicoumarol was used, along with heparin, ...
116 (4): 444-5. doi:10.1001/archderm.116.4.444. PMID 7369776. Chan YC, Valenti D, Mansfield AO, Stansby G (March 2000). " ... 90 (4 Pt 2): 671-2. doi:10.1016/S0029-7844(97)00393-1. PMID 11770590. S2CID 20764940. Nalbandian RM, Mader IJ, Barrett JL, ... 298 (6668): 233-4. doi:10.1136/bmj.298.6668.233. PMC 1835547. PMID 2522326. Makris M, Bardhan G, Preston FE (March 1996). " ... 75 (3): 523-4. doi:10.1055/s-0038-1650312. PMID 8701423. S2CID 30576117. Kiehl R, Hellstern P, Wenzel E (January 1987). " ...
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a ... Although 4-hydroxycoumarin itself is not an anticoagulant, it is an important fungal metabolite from the precursor coumarin, ... 4-hydroxycoumarins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Synthesis (4-Hydroxycoumarins, ... The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not ...
7-Hydroxycoumarins use Umbelliferones. 8,11,14-Eicosatrienoic Acid. 8-Bromo-CAMP use 8-Bromo Cyclic Adenosine Monophosphate ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...
7-Hydroxycoumarins use Umbelliferones. 8,11,14-Eicosatrienoic Acid. 8-Bromo-CAMP use 8-Bromo Cyclic Adenosine Monophosphate ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...
7-Hydroxycoumarins use Umbelliferones. 8,11,14-Eicosatrienoic Acid. 8-Bromo-CAMP use 8-Bromo Cyclic Adenosine Monophosphate ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...
7-Hydroxycoumarins use Umbelliferones. 8,11,14-Eicosatrienoic Acid. 8-Bromo-CAMP use 8-Bromo Cyclic Adenosine Monophosphate ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...
7-Hydroxycoumarins use Umbelliferones. 8,11,14-Eicosatrienoic Acid. 8-Bromo-CAMP use 8-Bromo Cyclic Adenosine Monophosphate ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...
Sulfate4. *It is usually employed in the form of atropine sulfate (the sulfate [2:1] monohydrate salt of atropine), which has ... 4. The data indicate that cardiovascular responses caused by i.c.v. quipazine and DOI are primarily due to activation of ... Volume 4, Ter- and quinque-valent phosphorus acids and their derivatives. (1996) Black, R. M.; Harrison, J. M. (2009). "The ... 4. Pretreatment (30 min) with the non-selective muscarinic antagonists scopolamine (0.1, 0.3 or 1 mg kg(-1), i.p.) and atropine ...
On addition of 4 equivalents of fluoride and acetate to the CH3CN solution of the receptors 1 and 2, colour changes from light ... Two 4-hydroxy coumarin based dyes (1 and 2) have been synthesized and their anion detection ability has been studied, for ... Sensors, Anion sensors, Colorimetric sensors, Fluoride ions, Acetate ions, Azo dyes, 4-Hydroxycoumarins, Coumarins NMR ...
4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529.972.65 4-Hydroxycoumarins D3.830.219.446.520 D3.383.663.283.446.520 ... Cyclin-Dependent Kinase 4 D8.811.913.696.620.682.700.200.451 Cyclin-Dependent Kinase 5 D8.811.913.696.620.682.700.200.67.875 ... 4),Met(0)-ol-enkephalin D12.644.468.281.381.300 D12.644.400.575.281.381.500 D12.776.641.650.575.281.381.500 Dairy Products ... Nuclear Receptor Subfamily 4, Group A, Member 1 D12.776.260.698.209.400 D12.776.260.643.400 D12.776.930.669.209.400 Nuclear ...
4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529.972.65 4-Hydroxycoumarins D3.830.219.446.520 D3.383.663.283.446.520 ... Cyclin-Dependent Kinase 4 D8.811.913.696.620.682.700.200.451 Cyclin-Dependent Kinase 5 D8.811.913.696.620.682.700.200.67.875 ... 4),Met(0)-ol-enkephalin D12.644.468.281.381.300 D12.644.400.575.281.381.500 D12.776.641.650.575.281.381.500 Dairy Products ... Nuclear Receptor Subfamily 4, Group A, Member 1 D12.776.260.698.209.400 D12.776.260.643.400 D12.776.930.669.209.400 Nuclear ...
4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529.972.65 4-Hydroxycoumarins D3.830.219.446.520 D3.383.663.283.446.520 ... Cyclin-Dependent Kinase 4 D8.811.913.696.620.682.700.200.451 Cyclin-Dependent Kinase 5 D8.811.913.696.620.682.700.200.67.875 ... 4),Met(0)-ol-enkephalin D12.644.468.281.381.300 D12.644.400.575.281.381.500 D12.776.641.650.575.281.381.500 Dairy Products ... Nuclear Receptor Subfamily 4, Group A, Member 1 D12.776.260.698.209.400 D12.776.260.643.400 D12.776.930.669.209.400 Nuclear ...
Heterocyclic Compounds with 4 or More Rings D3.549 D3.633.400 (Replaced for 2016 by Heterocyclic Compounds, 4 or More Rings) ... 4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633. ... ErbB-4 D12.776.543.750.60.09.600 D12.776.543.750.630.09.600 Receptor, Fibroblast Growth Factor, Type 1 D12.776.543.750.60.440 ... 4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide D3.438.810.50. ...
Heterocyclic Compounds with 4 or More Rings D3.549 D3.633.400 (Replaced for 2016 by Heterocyclic Compounds, 4 or More Rings) ... 4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633. ... ErbB-4 D12.776.543.750.60.09.600 D12.776.543.750.630.09.600 Receptor, Fibroblast Growth Factor, Type 1 D12.776.543.750.60.440 ... 4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide D3.438.810.50. ...
Journal Article 2012; 33(Suppl 3): 155-160 PubMed PMID: 23353860 Citation Keywords: 4-Hydroxycoumarins:toxicity, Animals, ...
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one Term UI T043412. Date05/22/1995. LexicalTag NON. ThesaurusID ... 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one Aldocumar Apo-Warfarin Coumadin Coumadine Gen-Warfarin Marevan ... 4-Hydroxycoumarins [D03.383.663.283.446.520] * Acenocoumarol [D03.383.663.283.446.520.079] * Dicumarol [D03.383.663.283.446.520 ... 4-Hydroxycoumarins [D03.633.100.150.446.520] * Acenocoumarol [D03.633.100.150.446.520.079] * Dicumarol [D03.633.100.150.446.520 ...
Text; Format: print Publication details: Geneva : World Health Organization, 1987Title translated: Les progrès de la mise au point et de l utilisation des antiviraux et de l interféron : rapport dun Groupe scientifique de l OMS [réuni à Genàve du 10 au 13 mars 1987]; Progresos en el desarrollo y uso de medicamentos antivirales e interferones : informe de un Grupo Científico de la OMS [se reunió en Ginebra del 10 al13 de marzo de 1987].Online access: Click here to access online Availability: Items available for loan: WHO HQ (2)Call number: HQ SERIAL, ... Not available: WHO HQ: Withdrawn (1). ...
7-Hydroxycoumarins use Umbelliferones 7,12-Dimethylbenzanthracene use 9,10-Dimethyl-1,2-benzanthracene ... 4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease use Tyrosinemias 4-Nitrophenol-2-Hydroxylase use Cytochrome P-450 CYP2E1 ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
7-Hydroxycoumarins use Umbelliferones 7,12-Dimethylbenzanthracene use 9,10-Dimethyl-1,2-benzanthracene ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use 3-Oxo-5-alpha-Steroid 4-Dehydrogenase ...
7-Hydroxycoumarins use Umbelliferones 7,12-Dimethylbenzanthracene use 9,10-Dimethyl-1,2-benzanthracene ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use 3-Oxo-5-alpha-Steroid 4-Dehydrogenase ...
0 1 2 3 4 5 6 7 8 9 • A Aa Ae Aj Ao At • B Ba Be Bj Bo Bt • C Ca Ce Cj Co Ct • D Da De Dj Do Dt • E Ea Ee Ej Eo Et • F Fa Fe Fj ... Category talk:2-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-1,2,4-triazol-3-ones ... Talk:3β-(4-Chlorophenyl)-2β-(3-phenylisoxazol-5-yl)tropane ...
N-[(E)-2-Hydroxy-benzyl-idene]-5-methyl-isoxazole-4-carbohydrazide monohydrate. Jin, Yan-Xian; Yan, Zhen-Zhong; Yang, Jian-Guo ... 4.. Tuning Photophysical Properties via Positional Isomerization of the Pyridine Ring in Donor-Acceptor-Structured Aggregation- ... Direct 1,6-Difluoromethylation of 3-Methyl-4-nitro-5-styryl Isoxazoles by Photoredox-Promoted Radical Addition. Zheng, Jianli; ... Chiral squaramides as highly enantioselective catalysts for Michael addition reactions of 4-hydroxycoumarins and 4- ...
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Text; Format: print Publication details: Geneva : World Health Organization, 1995Availability: Items available for loan: WHO HQ (2)Call number: HQ SERIAL, ... ...
Vitamin K 75 mg IV over 9-day period, then IV infusion of 4 mg/hr x 17 days; 30 mg orally x 3 months, then 200 mg orally for ... Vitamin K 75 mg IV over 9-day period, then IV infusion of 4 mg/hr x 17 days; 30 mg orally x 3 months, then 200 mg orally for ... Over the past 5 years, 154 major outcomes with 8 deaths have been reported.[2,3,4,5,6,7] ... The indandione class includes compounds, such as diphacinone, pindoe, and chlorphacinone, whereas the 4-hydroxycoumarin class ...
2009 Nov 19;4(11):e7896. doi: 10.1371/journal.pone.0007896. PLoS One. 2009. PMID: 19936249 Free PMC article. ...
We investigated two cases of recurrent jaundice, both involving repeated exposure to phenprocoumon and suggestive of coumarin-induced hepatitis. The first patient showed the histologic picture of cholestasis during the second bout of jaundice, the other that of chronic aggressive hepatitis. In both …
IP - 4. DP - 1964 Oct. TI - POSTMORTEM VITREOUS GLUCOSE DETERMINATIONS.. PG - 485-91. FAU - STURNER, W Q. AU - STURNER WQ. FAU ... SO - J Forensic Sci 1964 Oct;9(4):485-91.. MeSH Mapping Project. In 2005, NLM began an OLDMEDLINE OT subject heading-to-MeSH ... For example, when the RN - A25P3CP5S7 (bromfenacoum) is added to an OLDMEDLINE citation, then the MH - 4-Hydroxycoumarins is ...
4. Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung ... Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: synthesis, ¹H/¹³C-NMR conformational and X-ray ... 9. Synthesis and characterization of some new 4-hydroxy-coumarin derivatives.. Al-Majedy YK; Kadhum AA; Al-Amiery AA; Mohamad ... Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents.. Zhang W; Li Z ...
Heterocyclic Compounds with 4 or More Rings,N0000008261, Heterocyclic Compounds, 2-Ring,N0000008260, Heterocyclic Compounds, 1- ... 4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid,N0000005194, Orphenadrine Hydrochloride,N0000005193, ... 4-Quinolones,N0000011390, Fatty Acids, Omega-6,N0000011389, Enzymes and Coenzymes,N0000011388, Argipressin,N0000011387, ... 4-tert-butyl-4-methoxydibenzoylmethane,N0000004364, Atropine Sulfate,N0000004362, Atracurium Besylate,N0000004360, ...
Heterocyclic Compounds with 4 or More Rings D3.549 D3.633.400 (Replaced for 2016 by Heterocyclic Compounds, 4 or More Rings) ... 4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633. ... ErbB-4 D12.776.543.750.60.09.600 D12.776.543.750.630.09.600 Receptor, Fibroblast Growth Factor, Type 1 D12.776.543.750.60.440 ... 4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide D3.438.810.50. ...
4-Hydroxycoumarins Preferred Term Term UI T044130. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1977). ... 4-Hydroxycoumarins [D03.383.663.283.446.520] * Acenocoumarol [D03.383.663.283.446.520.079] * Dicumarol [D03.383.663.283.446.520 ... 4-Hydroxycoumarins [D03.633.100.150.446.520] * Acenocoumarol [D03.633.100.150.446.520.079] * Dicumarol [D03.633.100.150.446.520 ... 4-Hydroxycoumarins Preferred Concept UI. M0023241. Registry Number. 0. Scope Note. Substances found in many plants, containing ...
4-Hydroxycoumarins Preferred Term Term UI T044130. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1977). ... 4-Hydroxycoumarins [D03.383.663.283.446.520] * Acenocoumarol [D03.383.663.283.446.520.079] * Dicumarol [D03.383.663.283.446.520 ... 4-Hydroxycoumarins [D03.633.100.150.446.520] * Acenocoumarol [D03.633.100.150.446.520.079] * Dicumarol [D03.633.100.150.446.520 ... 4-Hydroxycoumarins Preferred Concept UI. M0023241. Registry Number. 0. Scope Note. Substances found in many plants, containing ...
dos Santos, R.G.; Moura Bordado, J.C.; Mateus, M.M.. "1H-NMR dataset for hydroxycoumarins -Aesculetin, 4-Methylumbelliferone, ... "New Process for Treating of Cork Stoppers or Planks for the Reduction of Strange Aroma namely 2,4,6 Trichloroanisol". Granted/ ... "Reactions of N-, S- and O-nucleophiles with 3,4,6-tri-O-benzyl-D-glucal mediated by triphenylphosphane hydrobromide versus ... "Synthesis and Properties of Toluene-4-Sulfonyl Uretane of Hydroxypropylcellulose Liquid Crystal Polymers". Paper presented in ...
4-Hydroxycoumarins - Preferred Concept UI. M0023241. Scope note. Substances found in many plants, containing the 4- ... 4-hidroxicumarinas. Scope note:. Sustancias presentes en muchas plantas, que contienen el radical 4-hidroxicumarina. ... Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting ...
Three heretofore unknown merocyanine-based architectures were prepared using this strategy from aminonaphthols and 4- ... hydroxycoumarins. The ability to change the structure of original rhodol chromophore into π-expanded merocyanines translates to ... µ-4,5-(Me3Si)2pyridazine)]. The electrostatic interactions between the charge distributions on neighboring molecules inside the ... C-wide temperature range with a sensitivity of 4% °C-1. ... 4. From symmetry breaking to symmetry swapping: is Kashas rule ...
The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitors of HIV ... Antihuman immunodeficiency virus type 1 (HIV-1) activity of rare earth metal complexes of 4-hydroxycoumarins in cell culture ... Discovery of a Piperidine-4-carboxamide CCR5 Antagonist (TAK-220) with Highly Potent Anti-HIV-1 Activity ...
Enzymatic O-dealkylation yields 7-hydroxycoumarins, which have useful fluorescence properties. The substrates, which differed ...
4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529.972.65 4-Hydroxycoumarins D3.830.219.446.520 D3.383.663.283.446.520 ... Cyclin-Dependent Kinase 4 D8.811.913.696.620.682.700.200.451 Cyclin-Dependent Kinase 5 D8.811.913.696.620.682.700.200.67.875 ... 4),Met(0)-ol-enkephalin D12.644.468.281.381.300 D12.644.400.575.281.381.500 D12.776.641.650.575.281.381.500 Dairy Products ... Nuclear Receptor Subfamily 4, Group A, Member 1 D12.776.260.698.209.400 D12.776.260.643.400 D12.776.930.669.209.400 Nuclear ...
4-1BB Ligand D12.644.276.972.65 D12.776.467.972.65 D23.529.972.65 4-Hydroxycoumarins D3.830.219.446.520 D3.383.663.283.446.520 ... Cyclin-Dependent Kinase 4 D8.811.913.696.620.682.700.200.451 Cyclin-Dependent Kinase 5 D8.811.913.696.620.682.700.200.67.875 ... 4),Met(0)-ol-enkephalin D12.644.468.281.381.300 D12.644.400.575.281.381.500 D12.776.641.650.575.281.381.500 Dairy Products ... Nuclear Receptor Subfamily 4, Group A, Member 1 D12.776.260.698.209.400 D12.776.260.643.400 D12.776.930.669.209.400 Nuclear ...
Heterocyclic Compounds with 4 or More Rings D3.549 D3.633.400 (Replaced for 2016 by Heterocyclic Compounds, 4 or More Rings) ... 4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine D3.438.79.800 D3.633.100.79.800 2-Aminopurine D3.438.759.138.50 D3.633. ... ErbB-4 D12.776.543.750.60.09.600 D12.776.543.750.630.09.600 Receptor, Fibroblast Growth Factor, Type 1 D12.776.543.750.60.440 ... 4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- D3.438.834.700 D3.633.100.834.700 4-Hydroxyaminoquinoline-1-oxide D3.438.810.50. ...
4-Hydroxycoumarins Adolescent Adult Aged Blood Coagulation Disorders Cannabinoids Disease Outbreaks Female Humans Male Middle ...
Synthetic 7-hydroxy coumarins are used to absorb ultraviolet rays in sunscreen cosmetics and used in the synthesis of drugs ...
Chemical analysis of Fraxinus ornus revealed the presence of many compounds belonging mainly to the groups of hydroxycoumarins ... Int J of Pharm Rev & Res 2015; 5(4):328-337. 15. Al-Snafi AE. Therapeutic properties of medicinal plants: a review of plants ... long, apex acute to rounded, margin toothed, with scattered pubescence mainly on veins, with 4-7 basal veins. ... 4. Al-Snafi. AE. Adonis aestivalis: pharmacological and toxicological activities- A revew. Asian Journal of ...
  • 4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position (the ring-carbon between the hydroxyl and the carbonyl). (wikipedia.org)
  • Although 4-hydroxycoumarin itself is not an anticoagulant, it is an important fungal metabolite from the precursor coumarin, which is also not an anticoagulant, and its production leads to further fermentative production of the natural anticoagulant dicoumarol. (wikipedia.org)
  • Two 4-hydroxy coumarin based dyes ( 1 and 2 ) have been synthesized and their anion detection ability has been studied, for detection of fluoride and acetate ions selectively through the naked eye. (niscair.res.in)
  • A practical and efficient method for the synthesis of functionalized 4-(aryl-/heteroaryl-ethynyl)chroman-2-ones and 2-(aryl-/heteroaryl-ethynyl)chroman-4-ones through copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes, leading to the formation of C(sp)-C(sp3) bonds, has been unearthed. (bvsalud.org)
  • This happens in the presence of naturally occurring formaldehyde, which allows attachment of a second 4-hydroxycoumarin molecule through the linking carbon of the formaldehyde, to the 3-position of the first 4-hydroxycoumarin molecule, giving the semi-dimer the motif of the drug class. (wikipedia.org)
  • The identification of dicoumarol in 1940 is the precursor of the drug class known as 4-hydroxycoumarins. (wikipedia.org)
  • 5. Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinylidene-chroman-2,4-diones on cancer and non-cancer cell growth and death. (nih.gov)
  • 9. Synthesis and characterization of some new 4-hydroxy-coumarin derivatives. (nih.gov)
  • 10. Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: synthesis, ¹H/¹³C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations. (nih.gov)
  • 12. Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents. (nih.gov)
  • 13. Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents. (nih.gov)
  • X. Observations on the acetylation of 4-hydroxycoumarin and synthesis of 3-(alpha-aminophenylacetyl)-4-hydroxycoumarins]. (nih.gov)
  • 7. Larvicidal activity of 4-hydroxycoumarin derivatives against Aedes aegypti. (nih.gov)
  • A set of nine 4-aminomethyl-7-alkoxycoumarin derivatives was synthesized and characterized as substrates for O-dealkylation by recombinant cytochrome P450 2D6, a major human enzyme involved in drug metabolism. (nih.gov)
  • Pharmaceutical examples of 4-hydroxycoumarin pharmaceuticals include: acenocoumarol dicoumarol ethyl biscoumacetate phenprocoumon warfarin Compounds in this class have also been used as pesticides, specifically rodenticides. (wikipedia.org)
  • Substances found in many plants, containing the 4-hydroxycoumarin radical. (nih.gov)
  • Sustancias presentes en muchas plantas, que contienen el radical 4-hidroxicumarina. (bvsalud.org)
  • The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. (wikipedia.org)
  • The rodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin). (wikipedia.org)
  • The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. (wikipedia.org)
  • As such, these compounds form the most important and widely used subset of vitamin K antagonist drugs, but other such drugs exist which do not have the 4-hydroxycoumarin structure. (wikipedia.org)
  • [ 1 ] Superwarfarin rodenticides are grouped into 2 categories that include indandione and 4-hydroxycoumarins. (medscape.com)
  • The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. (wikipedia.org)