Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
Salts and esters of gentisic acid.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A flavoprotein that catalyzes the synthesis of protocatechuic acid from 4-hydroxybenzoate in the presence of molecular oxygen. EC 1.14.13.2.
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Benzoic acid or benzoic acid esters substituted with one or more chlorine atoms.
A genus of gram-negative, rod-shaped bacteria able to anaerobically oxidize and degrade toluene.
An antiseptic and disinfectant aromatic alcohol.
Derivatives of adipic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,6-carboxy terminated aliphatic structure.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3-hydroxykynurenine. It was formerly characterized as EC 1.14.1.2 and EC 1.99.1.5.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.
A family of gram-negative, aerobic bacteria utilizing only one-carbon organic compounds and isolated from in soil and water.
Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.
A species of METHYLOCOCCUS which forms capsules and is capable of autotrophic carbon dioxide fixation. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Benzoate derivatives that contain one or more alkyl or aryl groups linked to the benzene ring structure by OXYGEN.
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A species of gram-negative bacteria in the genus PSEUDOMONAS. It cannot utilize FRUCTOSE; GLUCOSE; or MALTOSE for energy.
Benzoic acid or benzoic acid esters substituted with one or more bromine atoms.
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A genus of gram-negative, rod-shaped, phototrophic bacteria found in aquatic environments. Internal photosynthetic membranes are present as lamellae underlying the cytoplasmic membrane.
Butanes are a group of hydrocarbon gases that can be used for anesthesia and analgesia in medical procedures.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1.
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
A group of compounds that are derivatives of heptanedioic acid with the general formula R-C7H11O4.
A species of METHYLOSINUS which is capable of degrading trichloroethylene and other organic pollutants.
A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.
The functional hereditary units of BACTERIA.
A genus of gram-negative, ellipsoidal or rod-shaped bacteria whose major source of energy and reducing power is from the oxidation of ammonia to nitrite. Its species occur in soils, oceans, lakes, rivers, and sewage disposal systems.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Proteins found in any species of bacterium.
The rate dynamics in chemical or physical systems.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
Life or metabolic reactions occurring in an environment containing oxygen.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as octane and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.
A family of gram-negative aerobic bacteria in the class BETA PROTEOBACTERIA, encompassing the acidovorans rRNA complex. Some species are pathogenic for PLANTS.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Inorganic compounds that contain tungsten as an integral part of the molecule.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A group of PROTEOBACTERIA represented by morphologically diverse, anaerobic sulfidogens. Some members of this group are considered bacterial predators, having bacteriolytic properties.
A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.
The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).
An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
An enzyme that utilizes NADH or NADPH to reduce FLAVINS. It is involved in a number of biological processes that require reduced flavin for their functions such as bacterial bioluminescence. Formerly listed as EC 1.6.8.1 and EC 1.5.1.29.
A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds.
A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.
These enzymes catalyze the elimination of ammonia from amidines with the formation of a double bond. EC 4.3.2.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
Derivatives of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton. Flavin derivatives serve an electron transfer function as ENZYME COFACTORS in FLAVOPROTEINS.
Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
A bacterial genus of the order ACTINOMYCETALES.
Enzymes that catalyze the rearrangement of geometry about double bonds. EC 5.2.
A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.
A widely used industrial solvent.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
A species of gram-positive, asporogenous, non-pathogenic, soil bacteria that produces GLUTAMIC ACID.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A family of gram-negative methanotrophs in the order Rhizobiales, distantly related to the nitrogen-fixing and phototrophic bacteria.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Proteins prepared by recombinant DNA technology.
Dicarboxylic acids are a group of organic acids that contain two carboxyl groups (-COOH) and are sometimes used in medical treatments for conditions such as metabolic disorders.
A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.
A family of aerobic gram-negative rods that are nitrogen fixers. They are highly viscous, and appear as a semitransparent slime in giant colonies.
Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)
The relationships of groups of organisms as reflected by their genetic makeup.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.
A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Phenols substituted with one or more chlorine atoms in any position.
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Toxic chlorinated unsaturated hydrocarbons. Include both the 1,1- and 1,2-dichloro isomers. Both isomers are toxic, but 1,1-dichloroethylene is the more potent CNS depressant and hepatotoxin. It is used in the manufacture of thermoplastic polymers.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Acetylene is not commonly used in the medical field.
A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A species of gram-negative bacteria in the genus PSEUDOMONAS, containing multiple genomovars. It is distinguishable from other pseudomonad species by its ability to use MALTOSE and STARCH as sole carbon and energy sources. It can degrade ENVIRONMENTAL POLLUTANTS and has been used as a model organism to study denitrification.
Propane is a hydrocarbon gas that is not commonly used in the medical field.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
A species of gram-negative, aerobic bacteria that is found in soil and which causes formation of root nodules on some, but not all, types of field pea, lentil, kidney bean, and clover.
A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
The sum of the weight of all the atoms in a molecule.
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
Compounds in which one or more of the three hydroxyl groups of glycerol are in ethereal linkage with a saturated or unsaturated aliphatic alcohol; one or two of the hydroxyl groups of glycerol may be esterified. These compounds have been found in various animal tissue.
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. It requires IRON and tetrahydropteridine.
A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Organic esters or salts of sulfonic acid derivatives containing an aliphatic hydrocarbon radical.
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A second-line antitubercular agent that inhibits mycolic acid synthesis.
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Cresols are a type of organic compound that can cause liver damage and are found in some disinfectants and solvents.
A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.
Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.
An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.
A genus of gram-negative rods which form exospores and are obligate methanotrophs.
Derivatives and polymers of styrene. They are used in the manufacturing of synthetic rubber, plastics, and resins. Some of the polymers form the skeletal structures for ion exchange resin beads.
Flavoproteins are proteins that contain a covalently bound flavin molecule and are involved in various biological processes, including metabolism and redox reactions.
An enzyme of the oxidoreductase class that catalyzes the formation of L-TYROSINE, dihydrobiopterin, and water from L-PHENYLALANINE, tetrahydrobiopterin, and oxygen. Deficiency of this enzyme may cause PHENYLKETONURIAS and PHENYLKETONURIA, MATERNAL. EC 1.14.16.1.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)
A family of anaerobic METHANOCOCCALES whose organisms are motile by means of flagella. These methanogens use carbon dioxide as an electron acceptor.
A genus of gram-negative, aerobic, spherical cells usually occurring in pairs. The resting stage is considered a cyst. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
A carcinogen that is often used in experimental cancer studies.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Norbornanes are a class of cyclic hydrocarbons that are not found naturally in the human body and are not used in medicine.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.
Ethane is not typically used in the medical field.
The facilitation of biochemical reactions with the aid of naturally occurring catalysts such as ENZYMES.
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
Hydroquinones are skin-lightening agents that are commonly used to treat hyperpigmentation.
A monooxygenase that catalyzes the conversion of BETA-CAROTENE into two molecules of RETINAL. It was formerly characterized as EC 1.13.11.21 and EC 1.18.3.1.
Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
A plant genus of the family APIACEAE. The roots are used as food.
A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
The type species of the genus NITROSOMONAS, a gram-negative chemolithotroph that oxidizes ammonia to nitrite. It is found in soil, sewage, freshwater, and on building walls, and especially in polluted areas where air contains high levels of nitrogen compounds.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in heme. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Transport proteins that carry specific substances in the blood or across cell membranes.
A genus of gram-negative, aerobic, straight, curved, or branched rods which are motile by a single polar flagellum. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Benzene derivatives are chemical compounds derived from benzene, a common organic chemical, that have medical applications.
Potent cholinesterase inhibitor used as an insecticide and acaricide.
A proposed family of bacteria belonging to the alpha-2 subgroup of PROTEOBACTERIA.
Proteins, usually acting in oxidation-reduction reactions, containing iron but no porphyrin groups. (Lehninger, Principles of Biochemistry, 1993, pG-10)

Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. Implications for NADPH recognition and structural stability. (1/76)

Phe161 and Arg166 of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens belong to a newly discovered sequence motif in flavoprotein hydroxylases with a putative dual function in FAD and NADPH binding [1]. To study their role in more detail, Phe161 and Arg166 were selectively changed by site-directed mutagenesis. F161A and F161G are catalytically competent enzymes having a rather poor affinity for NADPH. The catalytic properties of R166K are similar to those of the native enzyme. R166S and R166E show impaired NADPH binding and R166E has lost the ability to bind FAD. The crystal structure of substrate complexed F161A at 2.2 A is indistinguishable from the native enzyme, except for small changes at the site of mutation. The crystal structure of substrate complexed R166S at 2.0 A revealed that Arg166 is important for providing an intimate contact between the FAD binding domain and a long excursion of the substrate binding domain. It is proposed that this interaction is essential for structural stability and for the recognition of the pyrophosphate moiety of NADPH.  (+info)

Modelling flavin and substrate substituent effects on the activation barrier and rate of oxygen transfer by p-hydroxybenzoate hydroxylase. (2/76)

The simulation of enzymatic reactions, using computer models, is becoming a powerful tool in the most fundamental challenge in biochemistry: to relate the catalytic activity of enzymes to their structure. In the present study, various computed parameters were correlated with the natural logarithm of experimental rate constants for the hydroxylation of various substrate derivatives catalysed by wild-type para-hydroxybenzoate hydroxylase (PHBH) as well as for the hydroxylation of the native substrate (p-hydroxybenzoate) by PHBH reconstituted with a series of 8-substituted flavins. The following relative parameters have been calculated and tested: (a) energy barriers from combined quantum mechanical/molecular mechanical (QM/MM) (AM1/CHARMM) reaction pathway calculations, (b) gas-phase reaction enthalpies (AM1) and (c) differences between the HOMO and LUMO energies of the isolated substrate and cofactor molecules (AM1 and B3LYP/6-31+G(d)). The gas-phase approaches yielded good correlations, as long as similarly charged species are involved. The QM/MM approach resulted in a good correlation, even including differently charged species. This indicates that the QM/MM model accounts quite well for the solvation effects of the active site surroundings, which vary for differently charged species. The correlations obtained demonstrate quantitative structure activity relationships for an enzyme-catalysed reaction including, for the first time, substitutions on both substrate and cofactor.  (+info)

Antioxidative galloyl esters as enzyme inhibitors of p-hydroxybenzoate hydroxylase. (3/76)

Gallic acid and its esters were evaluated as enzyme inhibitors of recombinant p-hydroxybenzoate hydroxylase (PHBH), a NADPH-dependent flavin monooxygenase from Pseudomonas aeruginosa. n-Dodecyl gallate (DG) (IC(50)=16 microM) and (-)-epigallocatechin-3-O-gallate (EGCG) (IC(50)=16 microM), a major component of green tea polyphenols, showed the most potent inhibition, while product-like gallic acid did not inhibit the enzyme significantly (IC(50)>250 microM). Inhibition kinetics revealed that both DG and EGCG inhibited PHBH in a non-competitive manner (K(I)=18.1 and 14.0 microM, respectively). The enzyme inhibition was caused by specific binding of the antioxidative gallate to the enzyme, and by scavenging reactive oxygen species required for the monooxygenase reaction. Molecular modeling predicted that EGCG binds to the enzyme in the proximity of the FAD binding site via formation of three hydrogen bonds.  (+info)

Comparing protein-ligand interactions in solution and single crystals by Raman spectroscopy. (4/76)

By using a Raman microscope, we show that it is possible to probe the conformational states in protein crystals and crystal fragments under growth conditions (in hanging drops). The flavin cofactor in the enzyme para-hydroxybenzoate hydroxylase can assume two conformations: buried in the protein matrix ("in") or essentially solvent-exposed ("out"). By using Raman difference spectroscopy, we previously have identified characteristic flavin marker bands for the in and out conformers in the solution phase. Now we show that the flavin Raman bands can be used to probe these conformational states in crystals, permitting a comparison between solution and crystal environments. The in or out marker bands are similar for the respective conformers in the crystal and in solution; however, significant differences do exist, showing that the environments for the flavin's isoalloxazine ring are not identical in the two phases. Moreover, the Raman-band widths of the flavin modes are narrower for both in and out conformers in the crystals, indicating that the flavin exists in a more limited range of closely related conformational states in the crystal than in solution. In general, the ability to compare detailed Raman data for complexes in crystals and solution provides a means of bridging crystallographic and solution studies.  (+info)

Regulation of the p-hydroxybenzoic acid hydroxylase gene (pobA) in plant-growth-promoting Pseudomonas putida WCS358. (5/76)

The regulation of the p-hydroxybenzoate hydroxylase gene (pobA) of Pseudomonas putida WCS358 involved in the catabolism of p-hydroxybenzoic acid (PHB) to the central intermediate protocatechuate was studied. Protocatechuic acid (PCA) is then degraded via the beta-ketoadipate pathway to form tricarboxylic acid intermediates. In several Gram-negative bacteria pobA has been found genetically linked to a regulator called pobR which activates pobA expression in response to PHB. In this study the identification and characterization of the pobC-pobA locus of P. putida WCS358 is presented. The p-hydroxybenzoate hydroxylase (PobA) is highly identical to other identified PobA proteins, whereas the regulatory protein PobC did not display very high identity to other PobR proteins studied and belonged to the AraC family of regulatory proteins, hence it has been designated POBC: Using the pobA promoter transcriptionally fused to a promoterless lacZ gene it was observed that induction via PobC occurred very efficiently when PHB was present and to a lesser but still significant level also in the presence of PCA. This PobC-PCA response was genetically demonstrated by making use of pobC::Tn5 and pcaH::Tn5 mutants of strain WCS358 constructed in this study. In pobC mutants both the p-hydroxybenzoic and PCA response were not observed, whereas in the pcaH mutant, which lacks a functional protocatechuate 3,4-dioxygenase, the protocatechuic-acid-dependent pobA activation was still observed. Finally, the activation of pobA by PHB varied according to the concentration and it was observed that in the pcaR::Tn5 regulatory mutant of strain WCS358 the pobA promoter activity was reduced. PcaR is a regulator involved in the regulation of several loci of the beta-ketoadipate pathway, one of which is pcaK. It was postulated that the reduction of pobA activation in pcaR::Tn5 mutants was because there was no expression of the pcaK gene encoding the PHB transport protein resulting in lower levels of PHB present inside the cell.  (+info)

A study of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Improved purification, relative molecular mass, and amino acid composition. (6/76)

The purification procedure for p-hydroxybenzoate hydroxylase has been modified by replacement of the DEAE-cellulose (DE-32) column in the original procedure by a Sephadex--Cibacron-blue affinity column. In this way the yield of enzyme could be improved from 16% to about 40--50%. Preparative gel chromatography indicated that the enzyme does not exist as a monomeric species as earlier believed but mainly as a dimer. Sodium dodecyl sulfate gel electrophoresis of purified enzyme revealed a minimum relative molecular mass (Mr) of 43000--45000. Analytical gel chromatography, sedimentation equilibrium and sedimentation velocity experiments showed that the enzyme exists in solution mainly as a dimer but also in higher-order quaternary structures (presumably tetramer and hexamer). Temperature dependence of the distribution of the oligomers suggests that the association is of hydrophobic nature. The amino acid composition of the enzyme is also presented. The enzyme contains no disulfide but five sulfhydryl groups. In the native state of the enzyme only one sulfhydryl group is accessible to N-ethylmaleimide or 5,5'-dithiobis(2-nitrobenzoic acid). The iso-electric point of the enzyme was found to be 5.8.  (+info)

Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. (7/76)

para-Hydroxybenzoate hydroxylase catalyzes a two-step reaction that demands precise control of solvent access to the catalytic site. The first step of the reaction, reduction of flavin by NADPH, requires access to solvent. The second step, oxygenation of reduced flavin to a flavin C4a-hydroperoxide that transfers the hydroxyl group to the substrate, requires that solvent be excluded to prevent breakdown of the hydroperoxide to oxidized flavin and hydrogen peroxide. These conflicting requirements are met by the coordination of multiple movements involving the protein, the two cofactors, and the substrate. Here, using the R220Q mutant form of para-hydroxybenzoate hydroxylase, we show that in the absence of substrate, the large beta alpha beta domain (residues 1-180) and the smaller sheet domain (residues 180-270) separate slightly, and the flavin swings out to a more exposed position to open an aqueous channel from the solvent to the protein interior. Substrate entry occurs by first binding at a surface site and then sliding into the protein interior. In our study of this mutant, the structure of the complex with pyridine nucleotide was obtained. This cofactor binds in an extended conformation at the enzyme surface in a groove that crosses the binding site of FAD. We postulate that for stereospecific reduction, the flavin swings to an out position and NADPH assumes a folded conformation that brings its nicotinamide moiety into close contact with the isoalloxazine moiety of the flavin. This work clearly shows how complex dynamics can play a central role in catalysis by enzymes.  (+info)

Reaction of reduced flavins and flavoproteins with diphenyliodonium chloride. (8/76)

The reaction of diphenyliodonium chloride with free reduced flavins has been studied by stopped flow spectrophotometry under anaerobic conditions, and second order rate constants were determined as a function of pH. The reactive flavin species was identified as the reduced anion, based on an observed reaction pK of 6.7. The product mixture was independent of the initial concentration of reactant and contained approximately 20% oxidized flavin. The results can be modeled quantitatively on a modification of the mechanism proposed by Tew (Tew, D. G. (1993) Biochemistry 32, 10209-10215). The composition of the complex reaction mixture has been analyzed, and four flavin-phenyl adducts with distinctive absorbance and fluorescence characteristics have been identified, involving substitution at the flavin C4a, N5, and C8 positions. Inactivation of flavoprotein enzymes by diphenyliodonium has also been studied, and several examples were found where inactivation occurs readily, despite noninvolvement of radical intermediates in their reaction mechanisms. It can be concluded that inactivation by phenyliodonium species is not a valid indicator of catalytic mechanism involving radical intermediates. One of the several factors determining inactivation is maintenance of the enzyme flavin in the reduced form in the steady state of catalysis, the other factors being redox potential and accessibility of the inhibitor to the flavin active site.  (+info)

In the medical field, parabens are a class of preservatives that are commonly used in a variety of products, including personal care products such as shampoos, lotions, and cosmetics. Parabens are synthetic esters of p-hydroxybenzoic acid, which are effective at inhibiting the growth of bacteria, fungi, and yeast. Parabens are used in medical products such as topical creams, ointments, and gels to prevent the growth of microorganisms and extend the shelf life of the product. They are also used in some pharmaceutical products to prevent the growth of bacteria and fungi that can cause infections. However, there has been some concern in recent years about the potential health effects of parabens. Some studies have suggested that parabens may mimic the hormone estrogen in the body, which could potentially lead to reproductive problems, breast cancer, and other health issues. As a result, some medical professionals and consumers have chosen to avoid products containing parabens or to use alternative preservatives.

Hydroxybenzoates are a group of organic compounds that are commonly used as preservatives in a variety of medical and personal care products. They are derivatives of benzoic acid, which is a naturally occurring compound found in many fruits and vegetables. Hydroxybenzoates are used as preservatives because they have antimicrobial properties, which means they can inhibit the growth of bacteria, fungi, and other microorganisms that can cause spoilage or infection. They are often used in combination with other preservatives, such as parabens, to provide additional protection against microbial growth. In the medical field, hydroxybenzoates are used in a variety of products, including topical creams, ointments, and gels, as well as in some oral medications. They are also used in some medical devices, such as catheters and wound dressings, to prevent infection. It is important to note that while hydroxybenzoates are generally considered safe for use in medical products, they can cause skin irritation or allergic reactions in some people. As with any medical product, it is important to follow the instructions for use and to consult with a healthcare provider if you experience any adverse reactions.

Gentisates are a group of organic compounds that are formed from the metabolism of gentisic acid, which is a compound found in many plants. Gentisates are typically found in the urine of individuals who have consumed plants that contain gentisic acid, such as rue, wormwood, and tansy. In the medical field, gentisates are sometimes used as a diagnostic tool to help identify certain types of liver disease. For example, individuals with liver cirrhosis may have elevated levels of gentisates in their urine, which can be detected through a urine test. Gentisates may also be used as a marker of liver function, as the liver plays a role in the metabolism of gentisic acid and the formation of gentisates. It is important to note that while gentisates can be useful diagnostic tools, they are not specific to liver disease and can also be elevated in individuals with other conditions, such as kidney disease or certain types of cancer. Therefore, the presence of gentisates in the urine should be interpreted in the context of other clinical findings and laboratory tests.

In the medical field, oxygenases are enzymes that catalyze the addition of oxygen to a substrate molecule. These enzymes are involved in a wide range of biological processes, including the metabolism of drugs, the synthesis of hormones and other signaling molecules, and the detoxification of harmful substances. There are many different types of oxygenases, each with its own specific substrate and reaction mechanism. Some examples of oxygenases include cytochrome P450 enzymes, which are involved in the metabolism of drugs and other xenobiotics, and peroxidases, which are involved in the detoxification of reactive oxygen species. Oxygenases play a critical role in maintaining the health of living organisms, and their dysfunction can lead to a variety of diseases and disorders. For example, mutations in certain cytochrome P450 enzymes can lead to drug metabolism disorders, while deficiencies in peroxidases can contribute to the development of oxidative stress-related diseases.

Benzoic acid is a naturally occurring organic acid that is commonly used in the medical field as an antiseptic and preservative. It is a white crystalline solid that has a characteristic odor and is slightly soluble in water. In the medical field, benzoic acid is used in a variety of applications, including as a preservative in topical medications, such as creams and ointments, to prevent the growth of bacteria and other microorganisms. It is also used as an antiseptic in mouthwashes and other oral care products, and as a food preservative to prevent the growth of mold and bacteria in food and beverages. Benzoic acid is generally considered safe for use in humans, but high concentrations can cause skin irritation and other adverse effects. It is important to follow the recommended dosage and use instructions when using benzoic acid-containing products.

Mixed-function oxygenases are a class of enzymes that catalyze the oxidation of a wide range of substrates, including drugs, toxins, and endogenous compounds. These enzymes typically contain a non-heme iron or copper atom in their active site, which is coordinated by a variety of amino acid residues. Mixed-function oxygenases are involved in a variety of biological processes, including drug metabolism, xenobiotic detoxification, and the synthesis of important biological molecules such as cholesterol and bile acids. They are also involved in the metabolism of many environmental pollutants, including polycyclic aromatic hydrocarbons and halogenated hydrocarbons. In the medical field, mixed-function oxygenases are important because they play a key role in the metabolism of many drugs, which can affect their efficacy and toxicity. For example, the cytochrome P450 family of mixed-function oxygenases is responsible for the metabolism of many commonly prescribed drugs, including anti-inflammatory drugs, antidepressants, and anticoagulants. Understanding the role of these enzymes in drug metabolism is important for optimizing drug therapy and minimizing adverse drug reactions.

4-Hydroxybenzoate-3-monooxygenase is an enzyme that is involved in the metabolism of certain aromatic compounds, including benzoate and salicylate. It is encoded by the "COMT" gene in humans and is primarily found in the liver and kidneys. The enzyme catalyzes the conversion of 4-hydroxybenzoate to 3,4-dihydroxybenzoate, which is an intermediate in the metabolism of these compounds. This reaction involves the transfer of a hydroxyl group from a molecule of NADPH to the 3-position of the benzoate molecule. 4-Hydroxybenzoate-3-monooxygenase plays an important role in the detoxification of these compounds, as the resulting 3,4-dihydroxybenzoate can be further metabolized and excreted from the body. Mutations in the "COMT" gene can lead to a deficiency in the enzyme, which can result in a condition called homocystinuria, which is characterized by high levels of homocysteine in the blood.

In the medical field, benzoates are a class of organic compounds that are commonly used as preservatives in a variety of pharmaceutical and personal care products. They are derivatives of benzoic acid, which is a naturally occurring compound found in many fruits and vegetables. Benzoates are used in medical products to prevent the growth of bacteria, mold, and yeast, which can cause spoilage and other problems. They are also used as a preservative in some topical medications, such as creams and ointments, to help prevent the growth of bacteria and other microorganisms that can cause infections. Some common examples of benzoates used in medical products include sodium benzoate, potassium benzoate, and ethyl benzoate. These compounds are generally considered safe for use in medical products, but in some cases, they may cause allergic reactions or other adverse effects in some people. It is important for healthcare providers to carefully consider the potential risks and benefits of using benzoates in medical products, and to monitor patients for any signs of adverse reactions.

Chlorobenzoates are a group of organic compounds that are formed by the substitution of one or more chlorine atoms for hydrogen atoms in the benzene ring of benzoic acid. They are commonly used as preservatives in a variety of food and cosmetic products, as well as in the production of dyes, plastics, and pharmaceuticals. In the medical field, chlorobenzoates are primarily used as antiseptics and disinfectants. They have been shown to be effective against a wide range of microorganisms, including bacteria, viruses, and fungi. Chlorobenzoates are often used in combination with other antimicrobial agents to enhance their effectiveness. However, some chlorobenzoates have been associated with potential health risks, including skin irritation, respiratory problems, and allergic reactions. As a result, their use in certain products has been restricted or banned in some countries. It is important for healthcare professionals to be aware of the potential risks associated with chlorobenzoates and to use them only as directed by a qualified healthcare provider.

Phenol is a colorless, crystalline solid that has a strong, distinctive odor. It is a chemical compound that is commonly used in the medical field as an antiseptic and disinfectant. Phenol is effective against a wide range of microorganisms, including bacteria, viruses, and fungi. It is often used to clean wounds, instruments, and surfaces in medical settings to prevent the spread of infection. Phenol is also used as a preservative in some medications and vaccines. However, it can be toxic if ingested or inhaled in large amounts, and it can cause skin irritation and burns.

In the medical field, "adipates" is not a commonly used term. It is possible that you may be referring to "adipose tissue," which is the most common type of fat tissue in the human body. Adipose tissue is found throughout the body and is responsible for storing energy in the form of fat. It also plays a role in regulating body temperature and protecting organs. Adipose tissue is made up of adipocytes, which are specialized cells that store fat.

Kynurenine 3-monooxygenase (KMO) is an enzyme that plays a key role in the metabolism of the amino acid tryptophan. It is part of the kynurenine pathway, which is a series of enzymatic reactions that convert tryptophan into various downstream metabolites. KMO catalyzes the conversion of kynurenine to kynurenic acid, which is an endogenous antagonist of the N-methyl-D-aspartate (NMDA) receptor. This receptor is involved in the regulation of neurotransmission and has been implicated in a number of neurological and psychiatric disorders, including schizophrenia and depression. In addition to its role in the kynurenine pathway, KMO has also been shown to play a role in the metabolism of other amino acids, including histidine and tryptophan. Dysregulation of KMO activity has been implicated in a number of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

Acetyl-CoA C-acyltransferase (ACAT) is an enzyme that plays a role in the metabolism of lipids in the body. It catalyzes the transfer of an acetyl group from acetyl-CoA to a long-chain fatty acid, resulting in the formation of a fatty acyl-CoA ester. This reaction is an important step in the synthesis of triglycerides, which are the main form of stored fat in the body. ACAT is found in a number of tissues, including the liver, adipose tissue, and macrophages. In the liver, ACAT is involved in the synthesis of very low-density lipoproteins (VLDLs), which are responsible for transporting triglycerides from the liver to other parts of the body. In adipose tissue and macrophages, ACAT is involved in the synthesis of cholesterol esters, which are stored in lipid droplets. ACAT activity is regulated by a number of factors, including hormones, nutrients, and cellular signaling pathways. Dysregulation of ACAT activity has been implicated in a number of diseases, including atherosclerosis, diabetes, and obesity.

Hydroxybenzoate ethers are a class of organic compounds that are formed by the reaction of hydroxybenzoic acid with an alcohol. They are commonly used as preservatives in pharmaceuticals, cosmetics, and personal care products to prevent the growth of microorganisms. Some examples of hydroxybenzoate ethers include ethyl hydroxybenzoate, propyl hydroxybenzoate, and butyl hydroxybenzoate. These compounds are generally considered safe for use in humans, but high concentrations can cause skin irritation and allergic reactions in some people.

Bromobenzoates are a class of organic compounds that contain a bromine atom attached to a benzene ring. They are commonly used as preservatives in a variety of products, including pharmaceuticals, cosmetics, and food. In the medical field, bromobenzoates are used as antiseptics and disinfectants to prevent the growth of microorganisms. They are also used as topical anesthetics to numb the skin and reduce pain during medical procedures. Some examples of bromobenzoates used in the medical field include benzyl bromide, ethyl bromide, and propyl bromide.

Flavin-adenine dinucleotide (FAD) is a coenzyme that plays a crucial role in various metabolic processes in the body. It is a yellow-colored molecule that consists of a riboflavin (vitamin B2) molecule and an adenine nucleotide. FAD is involved in many enzymatic reactions that require the transfer of electrons, such as the metabolism of carbohydrates, fats, and proteins. It acts as an electron carrier, accepting electrons from one molecule and transferring them to another. FAD is also involved in the production of energy in the form of ATP (adenosine triphosphate), which is the primary energy currency of the body. In the medical field, FAD deficiency can lead to a variety of health problems, including neurological disorders, skin disorders, and metabolic disorders. FAD is also used as a dietary supplement to support various bodily functions, including energy metabolism and immune function.

Butanes are a group of hydrocarbons that contain four carbon atoms. They are commonly used as solvents, propellants, and refrigerants. In the medical field, butanes are not typically used for therapeutic purposes. However, they can be used as anesthetic agents in veterinary medicine. Butanes can also be found in some tobacco products, such as e-cigarettes and hookahs, and their use has been linked to various health risks, including addiction, lung damage, and cardiovascular disease.

The cytochrome P-450 enzyme system is a group of enzymes that are responsible for the metabolism of a wide variety of drugs, toxins, and other substances in the body. These enzymes are found in the liver, lungs, and other organs, and they play a critical role in the detoxification of harmful substances and the elimination of drugs from the body. The cytochrome P-450 enzymes are classified into several families, each of which is responsible for the metabolism of specific types of compounds. For example, the CYP3A family is responsible for the metabolism of a wide variety of drugs, including many commonly prescribed medications. The CYP2D6 family is responsible for the metabolism of some antidepressants, antipsychotics, and other drugs. The activity of the cytochrome P-450 enzyme system can be affected by a variety of factors, including genetic variations, age, sex, and the presence of other medications. In some cases, these factors can lead to differences in the metabolism of drugs, which can affect their effectiveness and the risk of side effects. Overall, the cytochrome P-450 enzyme system plays a critical role in the metabolism of drugs and other substances in the body, and understanding its function is important for the safe and effective use of medications.

Coenzyme A ligases are enzymes that catalyze the transfer of a coenzyme A (CoA) molecule to a substrate. Coenzyme A is a small molecule that plays a crucial role in many metabolic pathways in the body, including the breakdown of fatty acids and the synthesis of cholesterol and other lipids. Coenzyme A ligases are involved in a variety of biological processes, including the metabolism of carbohydrates, lipids, and proteins. They are also involved in the synthesis of certain hormones and other signaling molecules. In the medical field, coenzyme A ligases are of interest because they are involved in a number of diseases and disorders. For example, mutations in certain coenzyme A ligases have been linked to inherited metabolic disorders such as methylmalonic acidemia and propionic acidemia. These disorders are caused by a deficiency in the enzymes responsible for breaking down certain amino acids and fatty acids, leading to the accumulation of toxic byproducts in the body. In addition, coenzyme A ligases are being studied for their potential therapeutic applications. For example, some researchers are investigating the use of coenzyme A ligases as targets for the development of new drugs to treat metabolic disorders and other diseases.

Xylenes are a group of four organic compounds that are commonly used as solvents in various industries, including the medical field. They are composed of benzene rings with one or two methyl groups attached to them. In the medical field, xylenes are used as anesthetic agents for surgical procedures. They are administered intravenously or inhaled to induce anesthesia and are used to reduce pain and discomfort during surgery. Xylenes are also used as a solvent in the production of certain medications, such as antibiotics and anti-inflammatory drugs. However, it is important to note that xylenes can be toxic and can cause adverse effects if not used properly. Exposure to high levels of xylenes can lead to respiratory problems, dizziness, nausea, and even death. Therefore, medical professionals must follow strict guidelines and safety protocols when using xylenes in their practice.

Pimelic acids are a type of saturated fatty acid that are found in the cell walls of certain bacteria and archaea. They are also found in small amounts in some plants and animals. Pimelic acids are typically composed of 16 carbon atoms and have a distinctive chemical structure that makes them unique among fatty acids. In the medical field, pimelic acids have been studied for their potential therapeutic effects, including their ability to modulate the immune system and to have anti-inflammatory properties. They have also been shown to have antimicrobial activity against certain types of bacteria and fungi. However, more research is needed to fully understand the potential medical applications of pimelic acids.

Camphor 5-monooxygenase is an enzyme that is involved in the metabolism of camphor, a naturally occurring compound found in various plants. This enzyme catalyzes the conversion of camphor to 5-exo-hydroxycamphor, a metabolite that is further converted to other compounds in the body. In the medical field, camphor 5-monooxygenase is of interest because it is involved in the metabolism of certain drugs and toxins. For example, some drugs that are metabolized by this enzyme include the anti-inflammatory drug ibuprofen and the anticonvulsant drug phenytoin. In addition, camphor 5-monooxygenase is also involved in the metabolism of certain environmental toxins, such as polychlorinated biphenyls (PCBs) and dioxins. Disruptions in the activity of camphor 5-monooxygenase can lead to changes in the metabolism of these compounds, which may have implications for drug efficacy and toxicity. For example, genetic variations in the gene that encodes for this enzyme can affect its activity and may be associated with altered drug responses in individuals. Understanding the role of camphor 5-monooxygenase in drug metabolism and toxicity is important for the development of safer and more effective drugs.

Oxidoreductases are a class of enzymes that catalyze redox reactions, which involve the transfer of electrons from one molecule to another. These enzymes play a crucial role in many biological processes, including metabolism, energy production, and detoxification. In the medical field, oxidoreductases are often studied in relation to various diseases and conditions. For example, some oxidoreductases are involved in the metabolism of drugs and toxins, and changes in their activity can affect the efficacy and toxicity of these substances. Other oxidoreductases are involved in the production of reactive oxygen species (ROS), which can cause cellular damage and contribute to the development of diseases such as cancer and aging. Oxidoreductases are also important in the diagnosis and treatment of certain diseases. For example, some oxidoreductases are used as markers of liver disease, and changes in their activity can indicate the severity of the disease. In addition, some oxidoreductases are targets for drugs used to treat diseases such as cancer and diabetes. Overall, oxidoreductases are a diverse and important class of enzymes that play a central role in many biological processes and are the subject of ongoing research in the medical field.

NADP stands for Nicotinamide Adenine Dinucleotide Phosphate. It is a coenzyme that plays a crucial role in various metabolic processes in the body, including the metabolism of carbohydrates, fats, and proteins. NADP is involved in the conversion of glucose to glycogen, the breakdown of fatty acids, and the synthesis of amino acids. It is also involved in the process of photosynthesis in plants, where it acts as a carrier of electrons. In the medical field, NADP is often used as a supplement to support various metabolic processes and to enhance energy production in the body.

Carboxy-lyases are a class of enzymes that catalyze the cleavage of carbon-carbon bonds in organic molecules. These enzymes typically use a carboxyl group as a leaving group, resulting in the formation of two smaller molecules. Carboxy-lyases are involved in a variety of metabolic pathways, including the breakdown of amino acids, fatty acids, and carbohydrates. They are also involved in the biosynthesis of certain compounds, such as vitamins and hormones. In the medical field, carboxy-lyases are of interest because they play a role in the metabolism of drugs and other xenobiotics, and may be targeted for the development of new therapeutic agents.

Ubiquinone, also known as coenzyme Q10, is a naturally occurring antioxidant that is involved in the production of energy within cells. It is found in every cell in the body and is particularly concentrated in the mitochondria, which are the energy-producing structures within cells. In the medical field, ubiquinone is sometimes used as a dietary supplement to support heart health and energy levels. It is also being studied for its potential role in treating a variety of conditions, including Parkinson's disease, Alzheimer's disease, and cancer. However, more research is needed to fully understand the potential benefits and risks of using ubiquinone as a supplement or in the treatment of these conditions.

Bacterial proteins are proteins that are synthesized by bacteria. They are essential for the survival and function of bacteria, and play a variety of roles in bacterial metabolism, growth, and pathogenicity. Bacterial proteins can be classified into several categories based on their function, including structural proteins, metabolic enzymes, regulatory proteins, and toxins. Structural proteins provide support and shape to the bacterial cell, while metabolic enzymes are involved in the breakdown of nutrients and the synthesis of new molecules. Regulatory proteins control the expression of other genes, and toxins can cause damage to host cells and tissues. Bacterial proteins are of interest in the medical field because they can be used as targets for the development of antibiotics and other antimicrobial agents. They can also be used as diagnostic markers for bacterial infections, and as vaccines to prevent bacterial diseases. Additionally, some bacterial proteins have been shown to have therapeutic potential, such as enzymes that can break down harmful substances in the body or proteins that can stimulate the immune system.

Phenols are a class of organic compounds that contain a hydroxyl (-OH) group attached to an aromatic ring. In the medical field, phenols are commonly used as antiseptics and disinfectants due to their ability to kill bacteria, viruses, and fungi. They are also used as topical anesthetics and as ingredients in certain medications. Phenols can be found naturally in many plants and fruits, such as cloves, cinnamon, and citrus fruits. They are also used in the production of a variety of consumer products, including soaps, shampoos, and cleaning agents. However, some phenols can be toxic and can cause skin irritation, respiratory problems, and other health issues if they are not used properly. Therefore, it is important to follow proper safety guidelines when handling and using phenols in the medical field.

Protocatechuate-3,4-dioxygenase (P34OD) is an enzyme that plays a role in the metabolism of aromatic compounds in the body. It is involved in the breakdown of protocatechuic acid, a compound that is produced during the metabolism of certain amino acids and other compounds. P34OD is found in a variety of organisms, including bacteria, fungi, and plants. In humans, it is primarily found in the liver and other tissues that are involved in the metabolism of aromatic compounds. The enzyme catalyzes the conversion of protocatechuic acid to hydroquinone and carbon dioxide. This reaction is an important step in the degradation of aromatic compounds in the body, and it is also involved in the biosynthesis of certain pigments and other compounds. In the medical field, P34OD has been studied in relation to a number of different conditions, including liver disease, cancer, and neurodegenerative disorders. For example, some studies have suggested that changes in the activity of P34OD may be involved in the development of certain types of liver cancer. Additionally, P34OD has been proposed as a potential target for the development of new drugs for the treatment of these and other conditions.

Hydrolases are a class of enzymes that catalyze the hydrolysis of various substrates, including water, to break down complex molecules into simpler ones. In the medical field, hydrolases play important roles in various physiological processes, including digestion, metabolism, and detoxification. For example, digestive enzymes such as amylase, lipase, and protease are hydrolases that break down carbohydrates, fats, and proteins, respectively, in the digestive tract. In the liver, enzymes such as alcohol dehydrogenase and cytochrome P450 are hydrolases that detoxify harmful substances such as alcohol and drugs. Hydrolases can also be used in medical treatments. For example, proteolytic enzymes such as trypsin and chymotrypsin are used in some digestive enzyme supplements to aid in the digestion of proteins. Additionally, hydrolases such as hyaluronidase are used in some medical procedures to break down connective tissue and improve tissue permeability. Overall, hydrolases are an important class of enzymes in the medical field, playing critical roles in various physiological processes and serving as potential therapeutic targets for various diseases and conditions.

Organophosphates are a class of chemical compounds that contain a phosphorus atom bonded to an organic group. They are commonly used as pesticides, herbicides, and insecticides, as well as in industrial and military applications. In the medical field, organophosphates are often used as nerve agents, which can cause a range of symptoms including muscle weakness, difficulty breathing, and even death. They can also be used as medications to treat certain medical conditions, such as glaucoma and myasthenia gravis. However, exposure to organophosphates can be dangerous and can cause a range of adverse health effects, including respiratory problems, neurological damage, and even death.

Dioxygenases are a class of enzymes that catalyze the addition of molecular oxygen (O2) to a substrate molecule. These enzymes are involved in a wide range of biological processes, including the metabolism of lipids, carbohydrates, and amino acids, as well as the detoxification of harmful substances. Dioxygenases can be classified into several different types based on the specific chemical reaction they catalyze and the type of substrate they act on. For example, cytochrome P450 enzymes are a type of dioxygenase that are involved in the metabolism of drugs and other xenobiotics, while lipoxygenases are involved in the metabolism of fatty acids. Dioxygenases play an important role in maintaining the health of living organisms, but they can also contribute to the development of disease. For example, certain mutations in dioxygenase genes can lead to the production of abnormal enzymes that are unable to function properly, which can result in a variety of health problems. Additionally, some dioxygenases can produce reactive oxygen species (ROS) as a byproduct of their activity, which can cause damage to cellular components and contribute to the development of diseases such as cancer and aging.

Alkane 1-monooxygenase (also known as aldehyde dehydrogenase 3 family member A1 or ALDH3A1) is an enzyme that is involved in the metabolism of alkanes, which are hydrocarbons that contain only single bonds between carbon atoms. This enzyme catalyzes the conversion of alkanes to their corresponding aldehydes, which can then be further metabolized by other enzymes in the body. Alkane 1-monooxygenase is primarily found in the liver and is thought to play a role in the detoxification of certain environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs) and diesel exhaust particles. It is also involved in the metabolism of some drugs and alcohol. In the medical field, alkane 1-monooxygenase has been studied as a potential target for the development of new drugs for the treatment of liver disease and other conditions. For example, researchers have investigated the use of ALDH3A1 inhibitors to prevent the metabolism of certain drugs and increase their effectiveness, as well as the use of ALDH3A1 activators to enhance the detoxification of environmental pollutants.

In the medical field, Tungsten compounds are chemical compounds that contain the element tungsten. Tungsten is a heavy metal that is known for its high melting point and strength, and it is used in a variety of medical applications. One common use of tungsten compounds in medicine is in the production of medical devices, such as surgical instruments and prosthetic devices. Tungsten is often used in these devices because of its high strength and durability, which allows it to withstand the rigors of medical use. Tungsten compounds are also used in the treatment of certain medical conditions. For example, tungsten-based radioactive isotopes are used in radiation therapy to treat cancer. These isotopes emit radiation that can damage cancer cells, while leaving healthy cells relatively unharmed. In addition, tungsten compounds are used in the production of certain medical imaging technologies, such as X-ray machines and computed tomography (CT) scanners. Tungsten is used in these devices because of its high density, which allows it to absorb X-rays and produce clear, detailed images of the inside of the body. Overall, tungsten compounds play an important role in the medical field, and they are used in a variety of medical applications to improve patient care and treatment outcomes.

Benzydamine is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation in the mouth and throat. It is commonly used to treat conditions such as sore throat, tonsillitis, and mouth ulcers. Benzydamine is available in the form of lozenges, gels, and sprays, and it is usually taken as needed, up to four times a day. It is not recommended for use in children under the age of 12, and it should not be used for longer than seven days without consulting a healthcare provider.

Methane is not typically used in the medical field. It is a colorless, odorless gas that is the main component of natural gas and is also produced by the digestive processes of some animals, including humans. In the medical field, methane is not used for any therapeutic or diagnostic purposes. However, it can be used as a marker for certain digestive disorders, such as small intestinal bacterial overgrowth, as it is produced by certain types of bacteria in the gut.

Catechols are a class of organic compounds that contain a catechol group, which is a hydroxybenzene group with two hydroxyl (-OH) groups attached to a benzene ring. Catechols are found naturally in many plants and animals, and they are also synthesized in the body as part of various metabolic processes. In the medical field, catechols are often used as antioxidants and anti-inflammatory agents. They have been shown to have a number of potential health benefits, including reducing the risk of heart disease, improving blood flow, and protecting against oxidative stress. Catechols are also used in the production of a variety of pharmaceuticals and medical devices, including drugs for treating high blood pressure, heart disease, and Parkinson's disease. They are also used in the manufacturing of dyes, pigments, and other industrial chemicals.

Vanillic acid is a naturally occurring compound that is found in a variety of plants, including vanilla beans. It is a phenolic acid that is structurally related to p-hydroxybenzoic acid and has a molecular formula of C8H8O4. In the medical field, vanillic acid has been studied for its potential therapeutic effects, including its ability to reduce inflammation, improve cognitive function, and modulate the immune system. It has also been used in the treatment of certain skin conditions, such as eczema and psoriasis. However, more research is needed to fully understand the potential benefits and risks of vanillic acid as a therapeutic agent.

Tyrosine 3-monooxygenase (T3MO) is an enzyme that plays a role in the metabolism of tyrosine, an amino acid that is a precursor to many important molecules in the body, including neurotransmitters, hormones, and melanin. T3MO catalyzes the conversion of tyrosine to 3,4-dihydroxyphenylalanine (DOPA), which is then converted to dopamine, norepinephrine, and epinephrine by other enzymes. T3MO is primarily found in the brain and adrenal gland, and it is involved in the regulation of mood, motivation, and stress response. Abnormalities in T3MO activity have been linked to a number of neurological and psychiatric disorders, including depression, anxiety, and schizophrenia.

Squalene Monooxygenase is an enzyme that plays a crucial role in the biosynthesis of cholesterol in the human body. It catalyzes the conversion of squalene, a precursor molecule, into 2,3-oxidosqualene, which is a key intermediate in the production of cholesterol. This enzyme is located in the endoplasmic reticulum of liver cells and is encoded by the SQLE gene. Mutations in the SQLE gene can lead to a deficiency in squalene monooxygenase activity, which can result in a rare genetic disorder called Smith-Lemli-Opitz syndrome, characterized by abnormalities in cholesterol metabolism and multiple developmental defects.

Acyl Coenzyme A (acyl-CoA) is a molecule that plays a central role in metabolism. It is formed when an acyl group (a fatty acid or other long-chain hydrocarbon) is attached to the coenzyme A molecule, which is a small molecule that contains a thiol (-SH) group. Acyl-CoA molecules are involved in a variety of metabolic processes, including the breakdown of fatty acids (beta-oxidation), the synthesis of fatty acids (fatty acid synthesis), and the synthesis of other important molecules such as cholesterol and ketone bodies. In the medical field, acyl-CoA is often measured as a way to assess the activity of certain metabolic pathways, and imbalances in acyl-CoA levels can be associated with a variety of diseases and disorders.

FMN Reductase is an enzyme that plays a crucial role in the metabolism of flavin mononucleotide (FMN), a cofactor involved in various cellular processes. FMN Reductase catalyzes the reduction of FMN to flavin adenine dinucleotide (FAD), which is another important cofactor used in many metabolic reactions. In the medical field, FMN Reductase is of interest because it is involved in the metabolism of several drugs and toxins, including the antibiotic rifampicin and the carcinogen benzo[a]pyrene. Mutations in the gene encoding FMN Reductase have been associated with certain genetic disorders, such as Friedreich's ataxia, a neurodegenerative disease characterized by progressive loss of coordination and balance. In addition, FMN Reductase has been studied as a potential target for the development of new drugs for the treatment of various diseases, including cancer, infectious diseases, and neurological disorders.

Oxidoreductases Acting on CH-CH Group Donors are a group of enzymes that catalyze the transfer of hydrogen atoms from one molecule to another, with the CH-CH group acting as the donor. These enzymes are involved in a variety of biological processes, including the metabolism of fatty acids, the synthesis of cholesterol and other lipids, and the detoxification of harmful substances. In the medical field, these enzymes are often studied in the context of diseases related to lipid metabolism, such as obesity, diabetes, and cardiovascular disease. They are also important in the development of new drugs for the treatment of these conditions.

NADPH-Ferrihemoprotein Reductase, also known as NR5A1, is an enzyme that plays a crucial role in the metabolism of iron in the body. It is responsible for reducing ferrihemoprotein (Fe3+) to ferrous hemoprotein (Fe2+), which is an essential step in the absorption and transport of iron in the body. NR5A1 is primarily expressed in the liver, small intestine, and bone marrow, where it is involved in the regulation of iron homeostasis. It is also involved in the metabolism of other metals, such as copper and zinc. Deficiency or dysfunction of NR5A1 can lead to iron deficiency anemia, a condition characterized by low levels of iron in the body, which can cause fatigue, weakness, and other symptoms. It can also lead to other metabolic disorders, such as copper deficiency and zinc deficiency. In the medical field, NADPH-Ferrihemoprotein Reductase is an important target for the development of new treatments for iron deficiency anemia and other metabolic disorders.

Amidine-Lyases are a group of enzymes that catalyze the hydrolysis of amides to produce amines and carboxylic acids. These enzymes are involved in various metabolic pathways in living organisms, including the degradation of certain amino acids and the biosynthesis of other compounds. In the medical field, amidine-Lyases are of interest because they have been implicated in the metabolism of certain drugs and toxins. For example, some drugs that are metabolized by amidine-Lyases include the antiepileptic drug carbamazepine and the antidepressant drug tricyclic antidepressants. In addition, some toxins, such as the insecticide paraoxon, are also metabolized by amidine-Lyases. Abnormalities in the activity of amidine-Lyases can lead to metabolic disorders, such as hyperammonemia, which is a condition characterized by high levels of ammonia in the blood. This can be caused by mutations in genes that encode for amidine-Lyases, or by deficiencies in the enzymes themselves. In some cases, these abnormalities can be treated with medications that increase the activity of the enzymes or by dietary modifications.

In the medical field, a multienzyme complex is a group of two or more enzymes that are physically and functionally linked together to form a single, larger enzyme complex. These complexes can work together to catalyze a series of sequential reactions, or they can work in parallel to carry out multiple reactions simultaneously. Multienzyme complexes are found in a variety of biological processes, including metabolism, DNA replication and repair, and signal transduction. They can be found in both prokaryotic and eukaryotic cells, and they can be composed of enzymes from different cellular compartments. One example of a multienzyme complex is the 2-oxoglutarate dehydrogenase complex, which is involved in the citric acid cycle and the metabolism of amino acids. This complex consists of three enzymes that work together to catalyze the conversion of 2-oxoglutarate to succinyl-CoA. Multienzyme complexes can have important implications for human health. For example, mutations in genes encoding enzymes in these complexes can lead to metabolic disorders, such as maple syrup urine disease and glutaric acidemia type II. Additionally, some drugs target specific enzymes in multienzyme complexes as a way to treat certain diseases, such as cancer.

Flavins are a group of organic compounds that are important in various biological processes, including metabolism and energy production. In the medical field, flavins are often studied for their potential therapeutic applications, particularly in the treatment of diseases related to oxidative stress and inflammation. There are two main types of flavins: flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). FMN and FAD are both derivatives of riboflavin, a water-soluble vitamin that is essential for human health. FMN and FAD are involved in a wide range of biological processes, including the metabolism of carbohydrates, fats, and proteins, as well as the production of energy in the form of ATP. In addition to their metabolic functions, flavins also play a role in protecting cells from oxidative stress and inflammation. This is because flavins can act as antioxidants, neutralizing harmful molecules called free radicals that can damage cells and contribute to the development of diseases such as cancer, heart disease, and neurodegenerative disorders. Overall, flavins are an important class of compounds in the medical field, with potential applications in the treatment of a wide range of diseases and conditions.

Succinates are a class of organic compounds that contain the succinate functional group, which is a dicarboxylic acid with the chemical formula C4H6O4. In the medical field, succinates are often used as intermediates in the production of other chemicals and drugs, as well as in the treatment of certain medical conditions. One of the most well-known succinates in medicine is sodium succinate, which is used as a metabolic intermediate in the production of energy in the body. It is also used as a treatment for certain types of metabolic disorders, such as lactic acidosis, which is a condition characterized by an excess of lactic acid in the blood. Another example of a succinate used in medicine is propofol, which is a sedative and anesthetic medication that is commonly used in hospitals and medical procedures. Propofol is a derivative of the succinate molecule and is used to induce and maintain anesthesia in patients. Overall, succinates play an important role in the medical field as intermediates in the production of other chemicals and drugs, as well as in the treatment of certain medical conditions.

NAD stands for nicotinamide adenine dinucleotide, which is a coenzyme found in all living cells. It plays a crucial role in various metabolic processes, including energy production, DNA repair, and regulation of gene expression. In the medical field, NAD is often used as a supplement to support cellular health and improve overall well-being. It is also being studied for its potential therapeutic applications in treating conditions such as depression, anxiety, and chronic pain.

Cis-trans isomerases are a class of enzymes that catalyze the interconversion of cis and trans isomers of organic compounds. In the medical field, these enzymes are of particular interest because they play a role in the metabolism of various drugs and other compounds. For example, some cis-trans isomerases are involved in the metabolism of nonsteroidal anti-inflammatory drugs (NSAIDs) and other drugs that are used to treat pain and inflammation. These enzymes can also play a role in the metabolism of certain toxins and carcinogens, and they have been implicated in the development of certain types of cancer. In addition, cis-trans isomerases are involved in the biosynthesis of various natural products, including some that have important medicinal properties.

Trichloroethylene (TCE) is a colorless, sweet-smelling liquid that was once commonly used as a solvent in various industrial and commercial applications. In the medical field, TCE has been associated with a number of adverse health effects, including liver and kidney damage, cancer, and neurological disorders. TCE has been used as a general anesthetic in veterinary medicine, but its use has been largely discontinued due to concerns about its toxicity. In humans, TCE has been used as a surgical anesthetic, but it has been largely replaced by safer alternatives. In addition to its use as an anesthetic, TCE has also been used as a cleaning agent, degreaser, and solvent in various industrial and commercial settings. Exposure to TCE can occur through inhalation, ingestion, or skin contact, and it can cause a range of symptoms, including headache, dizziness, nausea, and respiratory problems. In recent years, there has been growing concern about the potential health effects of TCE exposure, particularly in relation to its use in industrial settings. As a result, many countries have implemented regulations to limit the use and release of TCE, and efforts are underway to develop safer alternatives to this toxic chemical.

In the medical field, oxygen is a gas that is essential for the survival of most living organisms. It is used to treat a variety of medical conditions, including respiratory disorders, heart disease, and anemia. Oxygen is typically administered through a mask, nasal cannula, or oxygen tank, and is used to increase the amount of oxygen in the bloodstream. This can help to improve oxygenation of the body's tissues and organs, which is important for maintaining normal bodily functions. In medical settings, oxygen is often used to treat patients who are experiencing difficulty breathing due to conditions such as pneumonia, chronic obstructive pulmonary disease (COPD), or asthma. It may also be used to treat patients who have suffered from a heart attack or stroke, as well as those who are recovering from surgery or other medical procedures. Overall, oxygen is a critical component of modern medical treatment, and is used in a wide range of clinical settings to help patients recover from illness and maintain their health.

Oxo-acid lyases are a class of enzymes that catalyze the cleavage of an oxo-acid substrate at the carbon-carbon bond adjacent to the oxygen atom. These enzymes are involved in various metabolic pathways and play important roles in the breakdown of amino acids, carbohydrates, and fatty acids. In the medical field, oxo-acid lyases are often studied in the context of their involvement in diseases such as cancer, diabetes, and obesity. For example, certain enzymes in this class have been shown to be upregulated in cancer cells, leading to increased metabolism and proliferation. In diabetes and obesity, alterations in the activity of oxo-acid lyases have been linked to impaired glucose metabolism and the development of insulin resistance. Overall, oxo-acid lyases are an important class of enzymes that play a critical role in metabolism and have implications for various diseases.

Toluene is a colorless, sweet-smelling liquid that is commonly used as a solvent in various industries, including the medical field. In the medical field, toluene is used as a topical anesthetic to numb the skin and reduce pain during medical procedures such as injections, wound care, and skin biopsies. It is also used as a component in some medications and as a cleaning agent for medical equipment. However, it is important to note that toluene can be toxic if ingested or inhaled in large amounts, and medical professionals are trained to use it safely and appropriately.

DNA, Bacterial refers to the genetic material of bacteria, which is a type of single-celled microorganism that can be found in various environments, including soil, water, and the human body. Bacterial DNA is typically circular in shape and contains genes that encode for the proteins necessary for the bacteria to survive and reproduce. In the medical field, bacterial DNA is often studied as a means of identifying and diagnosing bacterial infections. Bacterial DNA can be extracted from samples such as blood, urine, or sputum and analyzed using techniques such as polymerase chain reaction (PCR) or DNA sequencing. This information can be used to identify the specific type of bacteria causing an infection and to determine the most effective treatment. Bacterial DNA can also be used in research to study the evolution and diversity of bacteria, as well as their interactions with other organisms and the environment. Additionally, bacterial DNA can be modified or manipulated to create genetically engineered bacteria with specific properties, such as the ability to produce certain drugs or to degrade pollutants.

Recombinant proteins are proteins that are produced by genetically engineering bacteria, yeast, or other organisms to express a specific gene. These proteins are typically used in medical research and drug development because they can be produced in large quantities and are often more pure and consistent than proteins that are extracted from natural sources. Recombinant proteins can be used for a variety of purposes in medicine, including as diagnostic tools, therapeutic agents, and research tools. For example, recombinant versions of human proteins such as insulin, growth hormones, and clotting factors are used to treat a variety of medical conditions. Recombinant proteins can also be used to study the function of specific genes and proteins, which can help researchers understand the underlying causes of diseases and develop new treatments.

In the medical field, dicarboxylic acids are a group of organic compounds that contain two carboxylic acid groups (-COOH) attached to a central carbon atom. These acids are commonly found in the human body and play important roles in various physiological processes. Some examples of dicarboxylic acids include glutaric acid, adipic acid, and suberic acid. Glutaric acid is involved in the metabolism of amino acids and the breakdown of certain drugs. Adipic acid is a building block of adipose tissue and is involved in the regulation of energy metabolism. Suberic acid is a component of certain lipids and has been shown to have anti-inflammatory properties. In some cases, dicarboxylic acids can be present in the blood at abnormally high levels, which can indicate certain medical conditions such as glutaric aciduria type 1 or methylmalonic acidemia. These conditions are rare genetic disorders that affect the metabolism of certain amino acids or fatty acids, leading to the accumulation of dicarboxylic acids in the body.

In the medical field, isotopes are atoms of the same element that have different numbers of neutrons in their nuclei. These isotopes have the same atomic number (number of protons) but different atomic masses due to the difference in the number of neutrons. Isotopes are used in medical imaging and treatment because they can be used to track the movement of molecules within the body or to deliver targeted radiation therapy. For example, in positron emission tomography (PET) scans, a radioactive isotope is injected into the body and emits positrons, which are detected by a scanner to create images of the body's tissues and organs. In radiation therapy, isotopes such as iodine-131 or cobalt-60 are used to target and destroy cancer cells. There are many different isotopes used in medicine, and their properties are carefully chosen to suit the specific application. Some isotopes are naturally occurring, while others are produced in nuclear reactors or particle accelerators.

RNA, Ribosomal, 16S is a type of ribosomal RNA (rRNA) that is found in bacteria and archaea. It is a small subunit of the ribosome, which is the cellular machinery responsible for protein synthesis. The 16S rRNA is located in the 30S subunit of the ribosome and is essential for the binding and decoding of messenger RNA (mRNA) during translation. The sequence of the 16S rRNA is highly conserved among bacteria and archaea, making it a useful target for the identification and classification of these organisms. In the medical field, the 16S rRNA is often used in molecular biology techniques such as polymerase chain reaction (PCR) and DNA sequencing to study the diversity and evolution of bacterial and archaeal populations. It is also used in the development of diagnostic tests for bacterial infections and in the identification of antibiotic-resistant strains of bacteria.

In the medical field, alkanes are a group of organic compounds that consist of only carbon and hydrogen atoms. They are the simplest type of hydrocarbon and are often used as solvents, lubricants, and in the production of various medical products. Alkanes are typically classified based on the number of carbon atoms they contain, with the simplest alkane being methane (CH4) and the most complex being undecane (C11H24). Some common alkanes used in medicine include ethane (C2H6), propane (C3H8), butane (C4H10), and pentane (C5H12). Alkanes can be used in a variety of medical applications, including as solvents for medications, as components in medical devices, and as precursors for the production of other medical compounds. However, it is important to note that some alkanes can also be toxic and may cause adverse effects when inhaled or ingested in large quantities.

Oxidoreductases, O-demethylating are a group of enzymes that catalyze the removal of a methyl group from a substrate molecule. These enzymes are important in the metabolism of many drugs and other compounds, as well as in the detoxification of harmful substances. They are classified as oxidoreductases because they involve the transfer of electrons from one molecule to another. The O in the name refers to the fact that the methyl group is being removed from an oxygen-containing molecule. These enzymes play a crucial role in maintaining the balance of chemicals in the body and are involved in many physiological processes.

Succinic acid is a naturally occurring dicarboxylic acid that is found in many plants and animals. It is also produced industrially as a precursor to other chemicals, such as polyester and nylon. In the medical field, succinic acid is used as a metabolic intermediate in the citric acid cycle, which is a series of chemical reactions that occur in the mitochondria of cells to produce energy. It is also used as a medication to treat certain types of metabolic disorders, such as lactic acidosis, which is a condition characterized by an excess of lactic acid in the blood. Succinic acid is also used as a food additive, as a flavoring agent, and as a preservative. It is generally considered safe for consumption in small amounts, but larger amounts can be harmful and may cause symptoms such as nausea, vomiting, and diarrhea.

7-Alkoxycoumarin O-dealkylase is an enzyme that is involved in the metabolism of certain drugs and chemicals in the body. It is responsible for breaking down a specific type of molecule called 7-alkoxycoumarins, which are found in some medications and natural compounds. The enzyme catalyzes the removal of an alkyl group (a carbon-based molecule) from the 7-position of the coumarin molecule, resulting in the formation of a new compound. This process is an important step in the elimination of these substances from the body, and any disruption in the activity of the enzyme can affect the metabolism and elimination of the drug or chemical.

Membrane transport proteins are proteins that span the cell membrane and facilitate the movement of molecules across the membrane. These proteins play a crucial role in maintaining the proper balance of ions and molecules inside and outside of cells, and are involved in a wide range of cellular processes, including nutrient uptake, waste removal, and signal transduction. There are several types of membrane transport proteins, including channels, carriers, and pumps. Channels are pore-forming proteins that allow specific ions or molecules to pass through the membrane down their concentration gradient. Carriers are proteins that bind to specific molecules and change shape to transport them across the membrane against their concentration gradient. Pumps are proteins that use energy to actively transport molecules across the membrane against their concentration gradient. Membrane transport proteins are essential for the proper functioning of cells and are involved in many diseases, including cystic fibrosis, sickle cell anemia, and certain types of cancer. Understanding the structure and function of these proteins is important for developing new treatments for these diseases.

In the medical field, alkenes are a type of organic compound that contain at least one carbon-carbon double bond. They are unsaturated hydrocarbons, which means they have fewer hydrogen atoms than the maximum possible number for their molecular formula. Alkenes are commonly used in the production of various medical products, including drugs, plastics, and synthetic rubber. They are also used as solvents in some medical procedures and as components in medical devices. One example of an alkene used in medicine is propylene glycol, which is a common ingredient in many medications and medical devices. It is used as a solvent, a preservative, and a stabilizer. Another example is ethylene oxide, which is used as a sterilizing agent for medical equipment and as a precursor for the production of various medical products. Overall, alkenes play an important role in the medical field and are used in a variety of applications to improve patient care and medical technology.

Chlorophenols are a group of organic compounds that contain a chloro group (-Cl) attached to a phenol group (-OH). They are commonly used as disinfectants, preservatives, and as intermediates in the production of other chemicals. In the medical field, chlorophenols have been used as antiseptics and disinfectants for wounds and surfaces. They have also been used as preservatives in medical devices and pharmaceuticals. However, some chlorophenols have been associated with adverse effects on human health, including skin irritation, respiratory problems, and liver damage. As a result, the use of chlorophenols in some medical applications has been limited or banned in some countries.

Salicylates are a class of organic compounds that contain the functional group -COOH, which is commonly referred to as a carboxyl group. In the medical field, salicylates are primarily known for their anti-inflammatory and analgesic properties, and are commonly used to treat a variety of conditions such as headaches, fever, and pain. The most well-known salicylate is aspirin, which is a derivative of salicylic acid. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are chemicals that contribute to inflammation and pain. Other salicylates that are used in medicine include sodium salicylate, which is used to treat gout and rheumatoid arthritis, and methyl salicylate, which is used topically as a pain reliever and anti-inflammatory agent. However, it is important to note that salicylates can also have toxic effects at high doses, particularly in individuals with certain medical conditions such as kidney or liver disease. Therefore, the use of salicylates should always be supervised by a healthcare professional.

Durapatite is a synthetic bone substitute material that is used in orthopedic and dental surgeries. It is a type of calcium phosphate ceramic that is similar in composition to natural bone and is designed to promote bone growth and regeneration. Durapatite is typically used in procedures such as bone grafting, where it is placed in the body to help fill in gaps or defects in bone tissue. It can also be used as an alternative to autografts (bone taken from the patient's own body) or allografts (bone taken from a donor) in certain cases. Durapatite has several advantages over other bone substitute materials, including its ability to promote bone growth and its biocompatibility with the body. It is also relatively easy to shape and can be customized to fit the specific needs of each patient. Overall, Durapatite is a useful tool for surgeons and dentists who are looking for a safe and effective way to promote bone growth and regeneration in the body.

Dichloroethylenes are a group of chemicals that are composed of two chlorine atoms attached to an ethylene molecule. They are commonly used as solvents in various industrial processes, including the production of plastics, textiles, and adhesives. In the medical field, dichloroethylenes are sometimes used as anesthetic agents during surgery. However, they have also been linked to a number of health problems, including liver and kidney damage, central nervous system effects, and cancer. As a result, the use of dichloroethylenes as an anesthetic has been largely discontinued in many countries, and exposure to these chemicals in the workplace is tightly regulated to minimize the risk of harm to workers.

Naphthalenes are a group of organic compounds that are composed of two benzene rings fused together. They are commonly used as insecticides and moth repellents, and have also been used in the past as a treatment for certain medical conditions such as respiratory infections and skin infections. However, the use of naphthalenes as a medical treatment is now generally discouraged due to their potential toxicity and the availability of safer alternatives. In the medical field, naphthalenes are primarily used as a research tool to study the effects of benzene ring compounds on various biological processes.

Transferases are a class of enzymes that catalyze the transfer of a functional group from one molecule to another. In the medical field, transferases are often used to study liver function and to diagnose liver diseases. There are several types of transferases, including: 1. Alanine transaminase (ALT): This enzyme is found primarily in liver cells and is released into the bloodstream when liver cells are damaged or destroyed. High levels of ALT in the blood can indicate liver damage or disease. 2. Aspartate transaminase (AST): This enzyme is also found in liver cells, but it is also present in other tissues such as the heart, muscles, and kidneys. High levels of AST in the blood can indicate liver or heart damage. 3. Glutamate dehydrogenase (GDH): This enzyme is found in the liver, kidneys, and other tissues. High levels of GDH in the blood can indicate liver or kidney damage. 4. Alkaline phosphatase (ALP): This enzyme is found in the liver, bones, and other tissues. High levels of ALP in the blood can indicate liver or bone disease. Overall, transferases are important markers of liver function and can be used to diagnose and monitor liver diseases.

Acetylene is not typically used in the medical field. It is a colorless, flammable gas that is commonly used in welding and cutting applications. It is not used for medical purposes and should not be administered to patients. If you have any questions about medical terminology or treatments, it is important to speak with a qualified healthcare professional.

Alkyl and aryl transferases are a group of enzymes that catalyze the transfer of alkyl or aryl groups from one molecule to another. These enzymes play important roles in various biological processes, including metabolism, detoxification, and drug metabolism. In the medical field, alkyl and aryl transferases are often studied in the context of drug metabolism. Many drugs are metabolized by these enzymes, which can affect their efficacy and toxicity. For example, the enzyme cytochrome P450, which is a type of alkyl and aryl transferase, is responsible for the metabolism of many drugs, including some that are used to treat cancer, depression, and anxiety. Alkyl and aryl transferases are also involved in the metabolism of environmental toxins and carcinogens. For example, the enzyme glutathione S-transferase, which is another type of alkyl and aryl transferase, is responsible for the detoxification of many toxic compounds, including some that are found in tobacco smoke and air pollution. In addition to their role in drug metabolism and detoxification, alkyl and aryl transferases are also involved in the biosynthesis of various compounds, including lipids, steroids, and neurotransmitters. Understanding the function and regulation of these enzymes is important for developing new drugs and for understanding the mechanisms of disease.

Propane is a hydrocarbon gas that is commonly used as a fuel for heating, cooking, and other purposes. It is not typically used in the medical field for any therapeutic or diagnostic purposes. However, propane can be used as an anesthetic gas in veterinary medicine, particularly for small animals such as cats and dogs. In this context, propane is administered in a mixture with other gases, such as oxygen and nitrous oxide, to produce a state of anesthesia. Propane is also used as a propellant in medical devices such as inhalers and asthma pumps.

Ammonia is a chemical compound with the formula NH3. It is a colorless, pungent gas with a strong, unpleasant odor. In the medical field, ammonia is often used as a diagnostic tool to test for liver and kidney function. High levels of ammonia in the blood can be a sign of liver or kidney disease, as well as certain genetic disorders such as urea cycle disorders. Ammonia can also be used as a treatment for certain conditions, such as metabolic acidosis, which is a condition in which the body produces too much acid. However, ammonia can be toxic in high concentrations and can cause respiratory and neurological problems if inhaled or ingested.

Acetone is a colorless, flammable liquid that is commonly used as a solvent in various industries, including the medical field. In the medical field, acetone is primarily used as a topical anesthetic to numb the skin before procedures such as injections or minor surgeries. It is also used as a solvent to dissolve certain medications, such as insulin, and to clean medical equipment. Acetone is not typically used internally in medicine, as it can be toxic if ingested in large amounts.

In the medical field, copper is a trace element that is essential for various bodily functions. It plays a crucial role in the formation of red blood cells, the maintenance of healthy bones, and the proper functioning of the immune system. Copper is also involved in the metabolism of iron and the production of energy in the body. Copper deficiency can lead to a range of health problems, including anemia, osteoporosis, and impaired immune function. On the other hand, excessive copper intake can be toxic and can cause damage to the liver, kidneys, and other organs. In some medical treatments, copper is used as a component of certain medications, such as antibiotics and antifungal drugs. Copper is also used in medical devices, such as catheters and implants, due to its antimicrobial properties. Overall, copper is an important nutrient in the medical field, and its proper balance is crucial for maintaining good health.

Chloroquinolinols are a class of organic compounds that contain a quinoline ring with a chlorine atom attached to one of the nitrogen atoms. They are structurally related to quinolones, which are a class of antibiotics that are commonly used to treat bacterial infections. In the medical field, chloroquinolinols have been studied for their potential use as antimalarial agents. They have been shown to have activity against the Plasmodium parasite, which causes malaria, and have been used in the treatment of this disease in some parts of the world. However, their use has been limited due to concerns about their toxicity and the development of resistance in the parasite. In addition to their antimalarial activity, chloroquinolinols have also been studied for their potential use in the treatment of other infectious diseases, such as tuberculosis and leprosy. They have also been shown to have activity against certain types of cancer cells in the laboratory, although their potential as cancer treatments has not been fully explored.

Tryptophan hydroxylase (TPH) is an enzyme that plays a crucial role in the biosynthesis of the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) in the brain. Serotonin is a monoamine neurotransmitter that regulates mood, appetite, sleep, and other physiological processes. TPH catalyzes the hydroxylation of the amino acid tryptophan to form 5-hydroxytryptophan (5-HTP), which is then converted to serotonin by other enzymes in the brain. There are two main forms of TPH: TPH1 and TPH2. TPH1 is primarily expressed in the brainstem and is responsible for the majority of serotonin synthesis in the brain. TPH2 is expressed in other tissues, including the gut and immune system, and is involved in the synthesis of serotonin in these tissues. Abnormalities in TPH activity have been implicated in several neurological and psychiatric disorders, including depression, anxiety, and obsessive-compulsive disorder. For example, low levels of serotonin have been associated with depression, and some antidepressant medications work by increasing the levels of serotonin in the brain. Therefore, TPH is an important target for the development of new treatments for these disorders.

Epoxy compounds are a type of polymer that are commonly used in the medical field for a variety of applications. They are formed by the reaction of an epoxy resin with a curing agent, which results in a strong, durable material with excellent adhesion properties. In the medical field, epoxy compounds are often used as adhesives to bond medical devices to the skin or other tissues. They are also used as coatings on medical equipment and implants to provide a barrier against infection and to improve the durability and longevity of the device. Epoxy compounds are also used in the production of medical implants, such as dental fillings and orthopedic implants. They are used to bond the implant to the surrounding bone or tissue, providing a strong and secure hold. Overall, epoxy compounds are an important tool in the medical field, providing a range of benefits including improved adhesion, durability, and infection control.

Glyceryl ethers are a class of compounds that are formed by the reaction of glycerol (a trihydroxy alcohol) with an alkyl or aryl group. They are commonly used as solvents, plasticizers, and emulsifiers in various industries, including the pharmaceutical and medical fields. In the medical field, glyceryl ethers are used as excipients in the formulation of various drugs and medical products. They are known to have good solubility in water and lipids, which makes them useful in the formulation of both aqueous and oily solutions. They are also known to have low toxicity and are generally considered safe for use in humans. Some specific examples of glyceryl ethers used in the medical field include glyceryl monooleate (GMO), which is used as an emulsifier in parenteral nutrition solutions, and glyceryl trinitrate (GTN), which is used as a vasodilator to treat angina pectoris.

Flavin Mononucleotide (FMN) is a coenzyme that plays a crucial role in various metabolic processes in the body. It is a water-soluble molecule that contains a flavin ring and a ribose sugar moiety, which is linked to a phosphate group. FMN is a derivative of riboflavin, a vitamin that is essential for the proper functioning of the body. In the medical field, FMN is involved in a variety of biological processes, including energy metabolism, electron transport, and detoxification. It is a cofactor for several enzymes, including flavoprotein dehydrogenases, which are involved in the metabolism of carbohydrates, lipids, and amino acids. FMN is also a cofactor for enzymes involved in the detoxification of drugs and toxins. FMN deficiency can lead to a variety of health problems, including neurological disorders, skin disorders, and developmental delays. It is typically treated with high doses of riboflavin, which can be converted into FMN in the body. FMN is also used as a dietary supplement in some cases, particularly for individuals with FMN deficiency or for those who wish to support their overall health and wellness.

Benzoate 4-monooxygenase is an enzyme that is involved in the metabolism of benzoate, a chemical compound that is found in many foods and is also used as a preservative in some products. This enzyme catalyzes the conversion of benzoate to catechol, a chemical compound that is further metabolized by other enzymes in the body. Benzoate 4-monooxygenase is encoded by the "BMO" gene and is primarily found in the liver. It plays an important role in the detoxification of benzoate and other aromatic compounds in the body.

Camphor is a white, waxy, crystalline substance that has a strong, distinctive odor. It is a natural compound that is extracted from the bark of certain trees, including the camphor laurel tree. Camphor has a number of medicinal properties and has been used for centuries in traditional medicine to treat a variety of conditions, including respiratory infections, muscle pain, and skin irritations. It is also used as a topical analgesic and antiseptic, and as a component in some insect repellents. In the medical field, camphor is used in a variety of products, including cough drops, ointments, and inhalers. It is also used in some surgical procedures as a local anesthetic.

Alkanesulfonates are a class of compounds that contain a sulfonate group (-SO3H) attached to an alkane chain. They are commonly used in the medical field as surfactants, emulsifiers, and solubilizers in various pharmaceutical and cosmetic products. In particular, alkanesulfonates are often used as solubilizers to improve the solubility of poorly water-soluble drugs, allowing for better absorption and distribution in the body. They are also used as emulsifiers to stabilize oil-in-water emulsions, which are commonly used in topical creams and lotions. Some examples of alkanesulfonates used in the medical field include sodium lauryl sulfate (SLS), which is commonly used as a surfactant in shampoos and toothpaste, and sodium dodecyl sulfate (SDS), which is used as an emulsifier in some topical creams and ointments. It is worth noting that some alkanesulfonates have been associated with skin irritation and other adverse effects, particularly at high concentrations. As such, their use in medical products is typically carefully regulated to ensure their safety and efficacy.

Ethionamide is an antibiotic medication used to treat tuberculosis (TB). It is a member of the class of drugs called ethionamide derivatives, which are related to isoniazid. Ethionamide works by inhibiting the growth of bacteria that cause TB. Ethionamide is typically used in combination with other TB medications to increase the effectiveness of treatment and reduce the risk of the bacteria becoming resistant to the medication. It is usually taken orally in the form of tablets or capsules. Ethionamide can cause side effects such as nausea, vomiting, diarrhea, headache, and skin rash. It can also interact with other medications, so it is important to inform your doctor of all the medications you are taking before starting treatment with ethionamide.

Cresols are a group of organic compounds that contain a benzene ring with a hydroxyl group (-OH) attached to one of the carbon atoms. There are three types of cresols: m-cresol, o-cresol, and p-cresol, which differ in the position of the hydroxyl group on the benzene ring. In the medical field, cresols are used as disinfectants and antiseptics. They have bactericidal, fungicidal, and virucidal properties and are effective against a wide range of microorganisms. Cresols are commonly used in hospitals, clinics, and laboratories to disinfect surfaces, equipment, and instruments. However, cresols can also be toxic to humans and animals if ingested or inhaled in high concentrations. Exposure to cresols can cause skin irritation, respiratory problems, and damage to the liver and kidneys. Therefore, proper handling and disposal of cresols are essential to prevent accidental exposure and minimize the risk of adverse health effects.

Styrene is a colorless, flammable liquid that is commonly used in the production of various plastics and synthetic resins. It is not typically used in the medical field, as it is not considered to be biocompatible or safe for medical applications. However, styrene can be found in some medical devices and equipment, such as plastic syringes and medical-grade plastic tubing. In these cases, it is important to ensure that the styrene is not released into the body or environment, as it can be harmful if ingested or inhaled in large quantities.

Indigo Carmine is a synthetic blue dye that is used in various medical applications. It is commonly used as a food and beverage dye, as well as in cosmetics and textiles. In the medical field, Indigo Carmine is used as a diagnostic aid in the detection of certain medical conditions, such as gastrointestinal bleeding. It is also used as a stain in histology to highlight certain structures in tissue samples. In addition, Indigo Carmine is used as a dye in endoscopy to highlight the mucous membranes of the gastrointestinal tract, making it easier to visualize and diagnose any abnormalities.

Testolactone is a medication that is used to treat advanced prostate cancer in men who have stopped responding to other treatments. It is also used to treat breast cancer in women who have stopped responding to other treatments. Testolactone works by blocking the production of testosterone, which is a hormone that is important for the growth and development of prostate and breast cancer cells. It is usually taken as a pill, and the dosage and length of treatment will depend on the type and stage of cancer being treated. Testolactone can cause side effects such as hot flashes, nausea, and loss of appetite, and it may also increase the risk of developing blood clots.

Methimazole is a medication that is used to treat hyperthyroidism, a condition in which the thyroid gland produces too much thyroid hormone. It works by inhibiting the production of thyroid hormones in the thyroid gland. Methimazole is usually taken by mouth, and the dosage and duration of treatment will depend on the severity of the condition and the response of the patient to the medication. It is important to follow the instructions of a healthcare provider when taking methimazole, as it can have side effects and may interact with other medications.

In the medical field, "Hydrocarbons, Chlorinated" refers to a group of organic compounds that contain carbon and hydrogen atoms, with one or more chlorine atoms replacing some of the hydrogen atoms. These compounds are commonly used as solvents, degreasers, and in the production of various chemicals and plastics. Some chlorinated hydrocarbons, such as trichloroethylene (TCE) and perchloroethylene (PCE), have been linked to various health problems, including liver and kidney damage, cancer, and reproductive issues. Exposure to these compounds can occur through inhalation, ingestion, or skin contact, and can occur in the workplace or through contaminated water and soil. In recent years, there has been growing concern about the potential health effects of chlorinated hydrocarbons, and efforts have been made to reduce their use and exposure.

In the medical field, "iron" refers to a mineral that is essential for the production of red blood cells, which carry oxygen throughout the body. Iron is also important for the proper functioning of the immune system, metabolism, and energy production. Iron deficiency is a common condition that can lead to anemia, a condition in which the body does not have enough red blood cells to carry oxygen to the body's tissues. Symptoms of iron deficiency anemia may include fatigue, weakness, shortness of breath, and pale skin. Iron supplements are often prescribed to treat iron deficiency anemia, and dietary changes may also be recommended to increase iron intake. However, it is important to note that excessive iron intake can also be harmful, so it is important to follow the recommended dosage and consult with a healthcare provider before taking any iron supplements.

Phenobarbital is a barbiturate medication that is primarily used to treat seizures, particularly in people with epilepsy. It is also used to treat anxiety, insomnia, and other conditions that cause restlessness or agitation. Phenobarbital works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that helps to calm the brain and reduce seizures. It is available in both oral and injectable forms and is typically taken several times a day. Phenobarbital can cause side effects such as drowsiness, dizziness, and nausea, and it may interact with other medications. It is important to take phenobarbital exactly as prescribed by a healthcare provider to avoid the risk of side effects or overdose.

Pyrogallol is a naturally occurring organic compound that is commonly used in the medical field as an antiseptic, astringent, and a skin irritant. It is a trihydroxybenzene with the chemical formula C6H3(OH)3 and is a white or yellowish solid that is soluble in water and alcohol. In the medical field, pyrogallol is used as an antiseptic to treat minor cuts, burns, and wounds. It is also used as an astringent to help reduce swelling and inflammation, and as a skin irritant to help promote healing and prevent infection. Pyrogallol is available over-the-counter as a topical cream or ointment, and is typically applied directly to the affected area. It is important to note that pyrogallol can cause skin irritation and should be used with caution, especially on sensitive or broken skin. Additionally, pyrogallol should not be used on large areas of the body or for extended periods of time without consulting a healthcare professional.

Styrenes are a group of organic compounds that are widely used in the production of various plastics and resins. They are typically derived from the chemical reaction of benzene and ethylene, and are characterized by the presence of a benzene ring with a single ethyl group attached to it. In the medical field, styrenes are used in the production of medical devices and equipment, such as syringes, catheters, and medical tubing. They are also used in the production of medical packaging materials, such as plastic bags and containers. However, it is important to note that some styrenes, particularly styrene monomer, have been classified as potential human carcinogens by the International Agency for Research on Cancer (IARC). Exposure to high levels of styrene can cause respiratory problems, skin irritation, and other health issues. Therefore, proper handling and disposal of styrene-containing materials are essential to minimize the risk of exposure.

Flavoproteins are a class of proteins that contain a covalently bound flavin molecule, which is a prosthetic group consisting of a pyrazine ring and a ribityl side chain. Flavoproteins are involved in a wide range of biological processes, including metabolism, redox reactions, and signal transduction. Flavoproteins can be classified into two main types based on the type of flavin they contain: FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide). FMN is a reduced form of flavin, while FAD is an oxidized form. Flavoproteins play important roles in various medical conditions, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, flavoproteins such as NADH dehydrogenase and flavin reductase are involved in the electron transport chain, which is essential for energy production in cells. Mutations in genes encoding flavoproteins can lead to defects in this process, resulting in various diseases. In addition, flavoproteins are also involved in the metabolism of drugs and toxins, and are targets for the development of new drugs. For example, flavoproteins such as cytochrome P450 enzymes are involved in the metabolism of many drugs, and inhibitors of these enzymes can be used to enhance the efficacy of certain drugs or reduce their toxicity.

Phenylalanine hydroxylase (PAH) is an enzyme that plays a crucial role in the metabolism of the amino acid phenylalanine. It is encoded by the PAH gene and is located in the liver, kidneys, and other tissues. PAH catalyzes the conversion of phenylalanine to tyrosine, which is an essential amino acid that is used to produce neurotransmitters such as dopamine and norepinephrine. PAH is also involved in the production of melanin, a pigment that gives color to hair, skin, and eyes. Deficiency of PAH activity can lead to a genetic disorder called phenylketonuria (PKU), which is caused by mutations in the PAH gene. PKU is a rare but serious condition that can cause intellectual disability, seizures, and other neurological problems if left untreated. Treatment for PKU involves a strict low-phenylalanine diet to prevent the accumulation of toxic levels of phenylalanine in the body.

Aryl Hydrocarbon Hydroxylases (AHHs) are a group of enzymes that are involved in the metabolism of aromatic hydrocarbons, such as polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs). These enzymes are primarily found in the liver and are responsible for the oxidation of these compounds to their corresponding hydroxylated derivatives. AHHs play an important role in the detoxification of these compounds, as the hydroxylated derivatives are more water-soluble and can be more easily excreted from the body. In addition, the hydroxylation of aromatic hydrocarbons can also lead to the formation of reactive intermediates, such as quinones, which can be further metabolized or detoxified by other enzymes. AHHs are also involved in the metabolism of other compounds, such as certain drugs and hormones. Mutations in the genes encoding AHHs can lead to impaired metabolism of these compounds, which can result in toxicity or other health effects. In the medical field, AHHs are often studied in the context of their role in the metabolism of environmental pollutants and their potential health effects. For example, exposure to PAHs and HAHs has been linked to an increased risk of cancer and other health problems, and AHHs are thought to play a key role in this process.

Proadifen is a medication that was previously used to treat high blood pressure and to prevent blood clots. It is a type of medication called a "prostaglandin F2α receptor antagonist," which works by blocking the action of prostaglandin F2α, a hormone that can cause blood vessels to narrow and blood pressure to rise. Proadifen is no longer used for these purposes due to concerns about its safety and effectiveness. It has been replaced by other medications that are considered to be safer and more effective.

Anthraquinones are a group of naturally occurring organic compounds that are derived from the anthracene molecule. They are commonly found in plants, particularly in the roots, bark, and leaves of certain species. Anthraquinones have a variety of biological activities, including anti-inflammatory, anti-cancer, and anti-microbial properties. In the medical field, anthraquinones are used as ingredients in a number of medications and natural remedies. For example, some anthraquinones are used as laxatives to relieve constipation, while others are used to treat inflammatory bowel disease. Anthraquinones have also been studied for their potential use in treating cancer, particularly in the treatment of colon cancer and other types of gastrointestinal cancer.

Methylcholanthrene is a synthetic polycyclic aromatic hydrocarbon that is used as a laboratory chemical and as a carcinogen in research. It is classified as a mutagen and has been shown to cause cancer in animals and humans. In the medical field, methylcholanthrene is used as a model compound for studying the mechanisms of cancer development and for testing the efficacy of potential cancer treatments. It is also used in the development of new drugs and as a tool for studying the effects of environmental pollutants on human health.

Norbornanes are a class of organic compounds that are derived from the bicyclo[2.2.1]heptane ring system. They are typically used as intermediates in the synthesis of other organic compounds, and have also been studied for their potential medicinal applications. In the medical field, norbornanes have been investigated for their potential use as anti-inflammatory agents, as well as for their potential to treat a variety of neurological disorders, including Alzheimer's disease and Parkinson's disease. Some studies have also suggested that norbornanes may have antitumor properties, although more research is needed to confirm these findings. It is important to note that norbornanes are not currently approved for use as medical treatments, and more research is needed to fully understand their potential therapeutic effects and potential side effects.

Manganese is a chemical element with the symbol Mn and atomic number 25. It is a trace element that is essential for human health, but only in small amounts. In the medical field, manganese is primarily used to treat manganese toxicity, which is a condition that occurs when the body is exposed to high levels of manganese. Symptoms of manganese toxicity can include tremors, muscle weakness, and cognitive impairment. Treatment typically involves removing the source of exposure and providing supportive care to manage symptoms. Manganese is also used in some medical treatments, such as in the treatment of osteoporosis and in the production of certain medications.

Cytochromes b5 are a family of heme-containing proteins that play a crucial role in the metabolism of various drugs, hormones, and other xenobiotics in the body. They are found in many tissues, including the liver, kidney, and brain, and are involved in the oxidation of a wide range of substrates, including fatty acids, steroids, and drugs. Cytochromes b5 are also involved in the metabolism of some drugs, including anti-inflammatory drugs, antibiotics, and anticoagulants. They can either activate or inactivate these drugs, depending on the specific drug and the cytochrome b5 isoform involved. In the medical field, cytochromes b5 are important for understanding drug metabolism and predicting drug interactions. They are also being studied as potential targets for the development of new drugs for the treatment of various diseases, including cancer, cardiovascular disease, and neurological disorders.

Ethane is a colorless, odorless gas that is commonly used as a refrigerant and as a feedstock for the production of various chemicals, including plastics and solvents. It is not typically used in the medical field, as it is not considered to be a medically significant substance. However, ethane can be found in small amounts in the air we breathe and is a natural component of natural gas. It is also used as an anesthetic in veterinary medicine.

NADH and NADPH oxidoreductases are enzymes that play a crucial role in the electron transport chain, which is a series of chemical reactions that generate energy in the form of ATP (adenosine triphosphate) in cells. These enzymes are responsible for transferring electrons from NADH (nicotinamide adenine dinucleotide) and NADPH (nicotinamide adenine dinucleotide phosphate) to oxygen, which is then reduced to water. This process is known as oxidative phosphorylation and is a key part of cellular respiration. NADH and NADPH oxidoreductases are found in the inner mitochondrial membrane and are essential for the production of ATP in cells. Mutations in these enzymes can lead to a variety of diseases, including Leigh syndrome, Leber's hereditary optic neuropathy, and chronic granulomatous disease.

Steroid hydroxylases are a group of enzymes that catalyze the hydroxylation of steroids, which are a class of organic compounds that are important in various physiological processes in the body. These enzymes are responsible for modifying the structure of steroids by adding a hydroxyl group to specific positions on the steroid molecule. There are several different types of steroid hydroxylases, each of which is responsible for hydroxylating a specific position on the steroid molecule. For example, the enzyme 11β-hydroxylase is responsible for hydroxylating the 11β position of cortisol, a hormone that is produced by the adrenal gland. This hydroxylation reaction is important for the conversion of cortisol to cortisone, which is a less active form of the hormone. Steroid hydroxylases are important in the regulation of various physiological processes, including the metabolism of cholesterol, the production of sex hormones, and the regulation of the immune system. They are also involved in the synthesis of other important compounds, such as bile acids and vitamin D. In the medical field, steroid hydroxylases are often studied in the context of various diseases and disorders, such as Cushing's syndrome, which is a condition characterized by the overproduction of cortisol. In this condition, the activity of the enzyme 11β-hydroxylase is often increased, leading to an excess of cortisol in the body.

Hydroquinones are a class of organic compounds that are commonly used in the medical field as skin lightening agents. They work by inhibiting the production of melanin, a pigment that gives skin its color. Hydroquinones are often used to treat conditions such as melasma, a type of skin discoloration that is more common in women and is often caused by hormonal changes or sun exposure. They are also used to treat other types of skin discoloration, such as age spots and freckles. Hydroquinones are available in a variety of forms, including creams, lotions, and gels, and are typically applied to the skin once or twice a day. It is important to note that hydroquinones can cause skin irritation and should be used with caution, especially in individuals with sensitive skin.

Beta-carotene 15,15'-monooxygenase (BCMO) is an enzyme that plays a crucial role in the metabolism of beta-carotene, a provitamin A carotenoid found in many fruits and vegetables. In the human body, beta-carotene is converted into vitamin A, which is essential for maintaining healthy vision, skin, and immune function. BCMO is responsible for converting beta-carotene into two different forms of vitamin A: retinal and retinoic acid. BCMO is primarily found in the liver and small intestine, where it is involved in the absorption and metabolism of dietary beta-carotene. It is also expressed in other tissues, including the retina, where it plays a critical role in the conversion of beta-carotene into vitamin A for vision. Mutations in the BCMO gene can lead to a deficiency in the enzyme, resulting in a condition called beta-carotene deficiency. This condition can cause a range of symptoms, including night blindness, dry skin, and impaired immune function.

In the medical field, "Hydrocarbons, Aromatic" refers to a group of organic compounds that contain a ring of carbon atoms bonded to hydrogen atoms. These compounds are characterized by their strong odors and are often used as solvents, fuels, and industrial chemicals. Aromatic hydrocarbons are further classified into two main categories: polycyclic aromatic hydrocarbons (PAHs) and monoaromatic hydrocarbons. PAHs are compounds that contain two or more fused aromatic rings, while monoaromatic hydrocarbons contain only one aromatic ring. Exposure to aromatic hydrocarbons can have harmful effects on human health, including respiratory problems, skin irritation, and cancer. Some examples of aromatic hydrocarbons include benzene, toluene, and xylene, which are commonly found in gasoline, solvents, and other industrial products.

In the medical field, sulfides are a group of compounds that contain sulfur atoms bonded to other elements, such as carbon, oxygen, or nitrogen. Sulfides are often used as medications or as components of medications, and they can have a variety of effects on the body. One common use of sulfides in medicine is as anti-inflammatory agents. Sulfides have been shown to have anti-inflammatory properties, which can help to reduce swelling and pain in the body. They are also used as antioxidants, which can help to protect the body against damage from free radicals. Sulfides are also used in the treatment of certain types of cancer. Some sulfides have been shown to have anti-cancer properties, and they are being studied as potential treatments for a variety of cancers, including breast cancer, lung cancer, and colon cancer. In addition to their medicinal uses, sulfides are also used in a variety of other applications, including as industrial chemicals, as components of detergents and other cleaning products, and as components of certain types of plastics and other materials.

Benzopyrene Hydroxylase (CYP1A1) is an enzyme that plays a crucial role in the metabolism of polycyclic aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene. It is encoded by the CYP1A1 gene and is primarily expressed in the liver, lungs, and skin. The primary function of CYP1A1 is to catalyze the hydroxylation of PAHs, which converts them into more polar and water-soluble metabolites that can be more easily excreted from the body. This process is an important step in the body's defense against the toxic and carcinogenic effects of PAHs. Deficiency or mutations in the CYP1A1 gene can lead to reduced activity of the enzyme, which can result in increased susceptibility to PAH-induced toxicity and cancer. In addition, exposure to certain environmental factors, such as cigarette smoke and air pollution, can induce the expression of CYP1A1, leading to increased metabolism of PAHs and potentially increased cancer risk.

Ferredoxins are small, soluble electron transfer proteins that play a crucial role in cellular respiration and photosynthesis. They are found in a wide range of organisms, including bacteria, plants, and animals. In the context of cellular respiration, ferredoxins are involved in the transfer of electrons from one molecule to another, ultimately leading to the production of ATP (adenosine triphosphate), the energy currency of the cell. They are also involved in the detoxification of harmful molecules, such as hydrogen peroxide. In photosynthesis, ferredoxins are involved in the transfer of electrons from water to carbon dioxide, ultimately leading to the production of glucose and oxygen. They are also involved in the regulation of photosynthesis by controlling the flow of electrons through the photosynthetic electron transport chain. Ferredoxins are typically composed of four to eight alpha-helices and have a molecular weight of around 10-15 kDa. They are often found in association with other proteins, such as ferredoxin reductases, which are involved in the reduction of ferredoxins to their reduced form.

In the medical field, carrier proteins are proteins that transport molecules across cell membranes or within cells. These proteins bind to specific molecules, such as hormones, nutrients, or waste products, and facilitate their movement across the membrane or within the cell. Carrier proteins play a crucial role in maintaining the proper balance of molecules within cells and between cells. They are involved in a wide range of physiological processes, including nutrient absorption, hormone regulation, and waste elimination. There are several types of carrier proteins, including facilitated diffusion carriers, active transport carriers, and ion channels. Each type of carrier protein has a specific function and mechanism of action. Understanding the role of carrier proteins in the body is important for diagnosing and treating various medical conditions, such as genetic disorders, metabolic disorders, and neurological disorders.

Benzene derivatives are chemical compounds that are derived from benzene, which is a common organic compound with the chemical formula C6H6. Benzene derivatives are widely used in the medical field for a variety of purposes, including as drugs, as intermediates in the synthesis of other drugs, and as chemical reagents in medical research. Some examples of benzene derivatives that are used in medicine include anesthetics, analgesics, anti-inflammatory drugs, and anticancer drugs. For example, benzene derivatives such as lidocaine and procaine are commonly used as local anesthetics to numb the skin and other tissues during medical procedures. Other benzene derivatives, such as aspirin and ibuprofen, are used as nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain, reduce inflammation, and lower fever. Benzene derivatives are also used in the synthesis of other drugs, such as antibiotics, antihistamines, and antidepressants. In addition, benzene derivatives are used as chemical reagents in medical research to study the mechanisms of various biological processes and to develop new drugs and therapies. It is important to note that benzene is a known carcinogen, and exposure to high levels of benzene can cause a range of health problems, including leukemia and other blood disorders. As a result, benzene derivatives must be handled with care in the medical field, and appropriate safety measures must be taken to prevent exposure to benzene and its derivatives.

Fenthion is an organophosphate insecticide that is used to control a wide range of pests, including cockroaches, ants, and fleas. It works by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine in the nervous system. When acetylcholinesterase is inhibited, acetylcholine builds up in the nervous system, leading to overstimulation and eventually paralysis and death of the pest. Fenthion is available in various forms, including dusts, sprays, and granules, and is typically applied to surfaces or treated into food or water to control pests. It is also used as a pesticide in agriculture to protect crops from insect damage. In the medical field, fenthion is not typically used as a treatment for humans or animals. However, exposure to fenthion can cause symptoms such as nausea, vomiting, dizziness, and respiratory problems in humans. In severe cases, exposure to high levels of fenthion can lead to seizures, coma, and death. Therefore, it is important to use fenthion and other pesticides safely and according to the instructions provided by the manufacturer.

Nonheme iron proteins are a class of proteins that contain iron but do not have the heme prosthetic group. Heme is a complex organic molecule that contains an iron atom coordinated to a porphyrin ring, and it is found in many proteins involved in oxygen transport, such as hemoglobin and myoglobin. Nonheme iron proteins, on the other hand, contain iron that is not coordinated to a porphyrin ring and is instead bound to other ligands, such as histidine or cysteine residues. Nonheme iron proteins play a variety of roles in biological systems. For example, they are involved in the metabolism of iron, the detoxification of reactive oxygen species, and the catalysis of various chemical reactions. Some examples of nonheme iron proteins include ferritin, transferrin, and cytochrome P450 enzymes.

Dinitrocresols are a group of organic compounds that contain two nitro groups (-NO2) attached to a cresol ring. They are commonly used as disinfectants and antiseptics in the medical field. One specific dinitrocresol, 2,4-dinitrocresol, has been used as a topical antiseptic for wounds and skin infections. It has also been used as a preservative in some medical products, such as eye drops and injectable solutions. However, dinitrocresols have been associated with potential health risks, including skin irritation, respiratory irritation, and systemic toxicity. As a result, their use as antiseptics and preservatives has been limited in recent years, and alternative compounds have been developed.

Ampyrone is a medication that was previously used to treat certain types of infections, such as urinary tract infections and pneumonia. It is an antibiotic that works by inhibiting the growth of bacteria. However, it is no longer used in the medical field due to the development of antibiotic-resistant bacteria.

Safrole is a chemical compound that is found in the bark and leaves of certain plants, including sassafras, sweet flag, and nutmeg. It is also found in some essential oils, such as those derived from cinnamon, cassia, and wintergreen. In the medical field, safrole has been studied for its potential therapeutic effects, including its ability to act as an anticonvulsant, anti-inflammatory, and anti-cancer agent. However, it is also known to be a potent carcinogen, and exposure to high levels of safrole has been linked to the development of liver cancer in humans. As a result, the use of safrole as a dietary supplement or in the preparation of certain foods and beverages, such as absinthe and some types of herbal tea, is now restricted or banned in many countries.

Sulfoxides are a class of organic compounds that contain a sulfur-oxygen double bond (S=O). They are derivatives of sulfides, which have a sulfur-sulfur double bond (S=S). Sulfoxides are commonly used in the medical field as intermediates in the synthesis of other drugs and as anticonvulsants, antioxidants, and anti-inflammatory agents. They are also used as reagents in organic chemistry reactions. Some sulfoxides have been studied for their potential use in the treatment of cancer, but their effectiveness as anticancer agents is still being investigated.

In the medical field, ketones are organic compounds that are produced when the body breaks down fatty acids for energy. They are typically produced in the liver and are released into the bloodstream as a result of starvation, diabetes, or other conditions that cause the body to use fat as its primary source of energy. Ketones are often measured in the blood or urine as a way to diagnose and monitor certain medical conditions, such as diabetes or ketoacidosis. High levels of ketones in the blood or urine can indicate that the body is not getting enough insulin or is not using glucose effectively, which can be a sign of diabetes or other metabolic disorders. In some cases, ketones may be used as a treatment for certain medical conditions, such as epilepsy or cancer. They may also be used as a source of energy for people who are unable to consume carbohydrates due to certain medical conditions or dietary restrictions.

Thioamides are a class of organic compounds that contain a sulfur atom bonded to an amide group. They are commonly used in the medical field as drugs and as intermediates in the synthesis of other drugs. Thioamides have a wide range of biological activities, including antimicrobial, antifungal, and antiviral properties. They are also used as diuretics, antithyroid agents, and as treatments for certain types of cancer. Some examples of thioamides used in medicine include thiocyanate, thiourea, and methimazole.

In the medical field, "Hydrocarbons, Alicyclic" refers to a group of organic compounds that are composed solely of hydrogen and carbon atoms, and have a cyclic structure. These compounds are also known as alicyclic hydrocarbons or cycloalkanes. Alicyclic hydrocarbons are commonly found in nature and are used in a variety of applications, including as solvents, fuels, and pharmaceuticals. They are also used in the production of plastics, resins, and other materials. In the medical field, alicyclic hydrocarbons may be used as ingredients in medications or as solvents for other drugs. They may also be used as diagnostic agents in imaging studies, such as magnetic resonance imaging (MRI). It is important to note that some alicyclic hydrocarbons can be toxic and may cause adverse effects when inhaled, ingested, or absorbed through the skin. Therefore, proper handling and disposal of these compounds is important to prevent exposure and minimize the risk of harm.

Phenylacetates are a group of organic compounds that are formed by the reaction of phenylalanine with acetic acid. They are commonly found in the human body and are involved in various metabolic processes. In the medical field, phenylacetates are used as a source of energy for patients who are unable to produce energy from other sources, such as those with liver or kidney failure. They are also used to treat certain types of brain injury and to prevent the accumulation of toxic substances in the brain.

In the medical field, oxygen isotopes refer to the different forms of the element oxygen that have different atomic weights due to the presence of different numbers of neutrons in their nuclei. The most common oxygen isotopes are oxygen-16, oxygen-17, and oxygen-18. Oxygen-16 is the most abundant and is the form of oxygen that is found in the air we breathe. Oxygen-17 and oxygen-18 are less abundant and are often used in medical research and diagnostic imaging. Oxygen isotopes can be used to study the metabolism and function of various organs and tissues in the body, and can also be used to diagnose and treat certain medical conditions.

Benzopyrenes are a group of organic compounds that consist of a fused benzene ring and a pyrene ring. They are commonly found in the environment, including in tobacco smoke, automobile exhaust, and certain types of coal tar. In the medical field, benzopyrenes are of concern because they are known to be carcinogenic, meaning they can cause cancer. Exposure to benzopyrenes has been linked to an increased risk of lung cancer, skin cancer, and other types of cancer. They are also mutagenic, meaning they can cause changes in DNA that can lead to the development of cancer.

Benzoflavones are a class of organic compounds that are derived from the combination of a benzene ring and a flavone structure. They are a subclass of flavonoids, which are a large group of natural compounds found in plants that have a variety of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Benzoflavones are primarily found in certain fruits, vegetables, and herbs, such as citrus fruits, onions, and parsley. They have been studied for their potential health benefits, including their ability to protect against cancer, reduce inflammation, and improve cardiovascular health. In the medical field, benzoflavones have been investigated for their potential use in the treatment of various conditions, including cancer, cardiovascular disease, and inflammatory disorders. Some studies have suggested that benzoflavones may have anti-cancer properties, particularly in the prevention of breast and prostate cancer. They may also have a protective effect against cardiovascular disease by reducing inflammation and improving blood flow. However, more research is needed to fully understand the potential health benefits of benzoflavones and to determine the optimal dosage and duration of treatment. Additionally, some studies have suggested that benzoflavones may interact with certain medications, so it is important to consult with a healthcare provider before taking them.

Dithionite is a chemical compound that is used in various medical applications. It is a reducing agent that can be used to treat certain types of anemia, such as iron-deficiency anemia, by increasing the body's ability to absorb iron from the diet. It is also used as a treatment for certain types of cancer, such as breast cancer and ovarian cancer, by disrupting the growth and spread of cancer cells. In addition, dithionite is used as a preservative in some medical products, such as vaccines and blood products, to prevent the growth of bacteria and other microorganisms.

Methylamines are a class of organic compounds that contain a methyl group (-CH3) attached to an amine group (-NH2). They are commonly found in nature and are also synthesized in the laboratory for various applications. In the medical field, methylamines have been studied for their potential therapeutic effects. For example, methylphenidate, a methylamine derivative, is a stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Another methylamine, amantadine, is used to treat Parkinson's disease and influenza. Methylamines have also been studied for their potential toxic effects. Some methylamines, such as trimethylamine, can produce an unpleasant odor in the breath and urine when they are metabolized by the body. In addition, exposure to high levels of certain methylamines, such as dimethylamine, can cause respiratory and neurological symptoms. Overall, methylamines are an important class of compounds with both therapeutic and toxic properties, and their effects on the body are an active area of research in the medical field.

Thioacetazone is a medication that is used to treat tuberculosis (TB) in combination with other anti-TB drugs. It is a member of a class of drugs called thiazolidinediones, which work by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that causes TB. Thioacetazone is typically used in combination with other anti-TB drugs, such as isoniazid, rifampin, and pyrazinamide, to provide a more effective treatment for TB. It is usually given as a daily oral dose for several months. Thioacetazone can cause side effects, including nausea, vomiting, abdominal pain, and anemia. It can also cause liver damage, so regular liver function tests are usually performed during treatment to monitor for any potential problems. Thioacetazone is not recommended for use in pregnant women or people with certain medical conditions, such as liver disease or kidney disease. It is important to follow the instructions of a healthcare provider when taking thioacetazone and to report any side effects that occur.

L-amino acid oxidase (LAAO) is an enzyme that catalyzes the oxidative deamination of L-amino acids, which are the building blocks of proteins. This enzyme is found in various tissues throughout the body, including the liver, kidney, and brain. In the medical field, LAAO has been studied for its potential therapeutic applications. For example, LAAO has been shown to have anti-inflammatory and anti-cancer effects, and it may be useful in the treatment of various diseases, including cancer, neurodegenerative disorders, and inflammatory disorders. LAAO is also involved in the metabolism of certain drugs, and it has been shown to interact with a number of medications, including antidepressants, antipsychotics, and antihypertensives. As a result, the activity of LAAO may need to be taken into account when prescribing these drugs to patients. Overall, LAAO is an important enzyme that plays a role in various physiological processes, and it has potential therapeutic applications in the treatment of a range of diseases.

Benzene is a colorless, sweet-smelling liquid that is commonly used as a solvent in various industries, including the production of plastics, rubber, dyes, and detergents. In the medical field, benzene is not typically used as a treatment or medication, but it can be a hazardous substance that can cause health problems if exposure occurs. Long-term exposure to benzene can lead to a range of health problems, including leukemia, a type of cancer that affects the blood and bone marrow. Benzene can also cause damage to the liver, kidneys, and central nervous system, and it can affect the immune system and cause anemia. In the workplace, benzene exposure is regulated by the Occupational Safety and Health Administration (OSHA), which sets limits on the amount of benzene that workers can be exposed to over a certain period of time. Workers who are exposed to benzene may be required to wear protective clothing and equipment, and they may need to take breaks or use respiratory protection to reduce their exposure. In addition to workplace exposure, benzene can also be found in the environment, including in air, water, and soil. People who live in areas with high levels of benzene exposure may be at increased risk of health problems, including cancer and other types of illness.

In the medical field, isoenzymes refer to different forms of enzymes that have the same chemical structure and catalytic activity, but differ in their amino acid sequence. These differences can arise due to genetic variations or post-translational modifications, such as phosphorylation or glycosylation. Isoenzymes are often used in medical diagnosis and treatment because they can provide information about the function and health of specific organs or tissues. For example, the presence of certain isoenzymes in the blood can indicate liver or kidney disease, while changes in the levels of specific isoenzymes in the brain can be indicative of neurological disorders. In addition, isoenzymes can be used as biomarkers for certain diseases or conditions, and can be targeted for therapeutic intervention. For example, drugs that inhibit specific isoenzymes can be used to treat certain types of cancer or heart disease.

In the medical field, hydrocarbons are organic compounds that consist solely of hydrogen and carbon atoms. They are commonly found in various substances, including fossil fuels, crude oil, and natural gas. Hydrocarbons can be classified into two main categories: aliphatic hydrocarbons and aromatic hydrocarbons. Aliphatic hydrocarbons are those that do not contain any benzene rings, while aromatic hydrocarbons contain one or more benzene rings. In medicine, hydrocarbons are used in a variety of applications, including as solvents, lubricants, and as components in medications. Some hydrocarbons, such as benzene, are known to be toxic and can cause cancer and other health problems when inhaled or ingested in high concentrations. Therefore, it is important to handle hydrocarbons with care and follow proper safety protocols to prevent exposure.

55 (3): 888-96. doi:10.1016/0006-291X(73)91227-8. PMID 4148586. Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS (1969). "m- ... In enzymology, a 3-hydroxybenzoate 4-monooxygenase (EC 1.14.13.23) is an enzyme that catalyzes the chemical reaction 3- ... hydroxybenzoate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 3,4-dihydroxybenzoate + NADP+ + H2O The 4 substrates of ... The systematic name of this enzyme class is 3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). This enzyme is ...
Howell LG, Spector T, Massey V (July 1972). "Purification and properties of p-hydroxybenzoate hydroxylase from Pseudomonas ... Spector T, Massey V (July 1972). "Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas ... Hosokawa K, Stanier RY (May 1966). "Crystallization and properties of p-hydroxybenzoate hydroxylase from Pseudomonas putida". ... Spector T, Massey V (September 1972). "p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated ...
Fujii T, Kaneda T (1985). "Purification and properties of NADH/NADPH-dependent p-hydroxybenzoate hydroxylase from ... In enzymology, a 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] (EC 1.14.13.33) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is 4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating). Other names in ... Seibold B, Matthes M, Eppink MH, Lingens F, Van Berkel WJ, Muller R (1996). "4-Hydroxybenzoate hydroxylase from Pseudomonas sp ...
... may refer to: Benzoate 4-monooxygenase 4-hydroxybenzoate 3-monooxygenase This set index page ...
... may refer to: 4-hydroxybenzoate 3-monooxygenase (NAD(P)H) 4-hydroxybenzoate 3-monooxygenase ...
14 (3): 276-283. doi:10.1089/jmf.2010.0139. PMID 21182433. Hassan, S. T. S.; Švajdlenka, E.; Berchová-Bímová, K. (April 2017 ... The enzyme protocatechuate 3,4-dioxygenase uses 3,4-dihydroxybenzoate and O2 to produce 3-carboxy-cis,cis-muconate. Ethyl ... 43 (3): 474-477. doi:10.1042/bj0430474. PMC 1274717. PMID 16748434. Pacheco Palencia, L. A.; Mertens-Talcott, S; Talcott, S. T ... Biosynthesis enzymes 3-dehydroshikimate dehydratase (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase ...
... m-hydroxybenzoate 6-hydroxylase, and 3-hydroxybenzoic acid-6-hydroxylase. This enzyme participates in benzoate degradation via ... 55 (3): 897-903. doi:10.1016/0006-291X(73)91228-X. PMID 4357436. Portal: Biology v t e (Articles with short description, Short ... In enzymology, a 3-hydroxybenzoate 6-monooxygenase (EC 1.14.13.24) is an enzyme that catalyzes the chemical reaction 3- ... hydroxybenzoate + NADH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 2,5-dihydroxybenzoate + NAD+ + H2O The 4 substrates of ...
... camphor 5-monooxygenase MeSH D08.811.682.690.708.170.500 - alkane 1-monooxygenase MeSH D08.811.682.690.708.170.915 - steroid ... monophenol monooxygenase MeSH D08.811.682.690.708.170 - cytochrome p-450 enzyme system MeSH D08.811.682.690.708.170.040 - aryl ... monooxygenase MeSH D08.811.682.690.708.392.468 - Linoleoyl-CoA desaturase MeSH D08.811.682.690.708.392.625 - stearoyl-coa ... camphor 5-monooxygenase MeSH D08.244.453.915 - steroid hydroxylases MeSH D08.244.453.915.050 - aldosterone synthase MeSH ...
... and p-hydroxybenzoate hydroxylase. This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation ... In enzymology, a benzoate 4-monooxygenase (EC 1.14.14.92, Formerly EC 1.14.13.12) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use ... It has 3 cofactors: iron, Tetrahydrobiopterin, and Tetrahydropteridine. Reddy CC, Vaidyanathan CS (1975). "Purification, ...
119 (3): 595-602. doi:10.1111/j.1432-1033.1981.tb05649.x. PMID 6273164. Portal: Biology v t e (Articles with short description ... In enzymology, a 4-methoxybenzoate monooxygenase (O-demethylating) (EC 1.14.99.15) is an enzyme that catalyzes the chemical ... Twilfer H, Bernhardt FH, Gersonde K (1981). "An electron-spin-resonance study on the redox-active centers of the 4- ... methoxybenzoate monooxygenase from Pseudomonas putida". Eur. J. Biochem. ...
... where toluene is converted into o-cresol by toluene 2-monooxygenase and subsequently another monooxygenase converts it to 3- ... Subsequently, p-hydroxybenzoate is formed through oxidation of the methyl side chain. PK01: Pseudomonas pickettii PKO1 oxidizes ... A monooxygenase introduces an oxygen into the cyclic ketone and the cyclic ring is cleaved. For aromatic compounds there are ... The n-alkanes are oxidized by monooxygenase to secondary alcohols, then to ketones and finally to fatty acids. R 1 − ( CH 2 ...
... is a popular antioxidant in part because of its low toxicity. The LD50 is 2200 mg/kg in mice (oral). 4- ... 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as ... 4-Hydroxybenzoic acid has about one tenth the acidity of benzoic acid, having an acid dissociation constant Ka = 3.3×10−5 M at ... 4-Hydroxybenzoic acid can be found naturally in coconut. It is one of the main catechins metabolites found in humans after ...
1976). "Flavin-oxygen derivatives involved in the hydroxylation of p-hydroxybenzoate hydroxylase". J. Biol. Chem. 251 (9): 2550 ... but is believed to follow mechanisms related to the flavin-dependent monooxygenases. After L-kynurenine binds, NADPH reduces ... Tautomerization yields 3-hydroxy-L-kynurenine in complex with the enzyme (E Fl HOH-P). Dissociation of 3-hydroxy-L-kynurenine ... Kynurenine 3-monooxygenase serves as an important branch point in the kynurenine pathway and, as a result, is an attractive ...
EC 1.14.15.3: alkane 1-monooxygenase EC 1.14.15.4: steroid 11β-monooxygenase EC 1.14.15.5: corticosterone 18-monooxygenase EC ... valine N-monooxygenase EC 1.14.14.39: isoleucine N-monooxygenase EC 1.14.14.40: phenylalanine N-monooxygenase EC 1.14.14.41: (E ... steroid 17α-monooxygenase EC 1.14.99.10: Now EC 1.14.14.16, steroid 21-monooxygenase EC 1.14.99.11: estradiol 6β-monooxygenase ... arginine 2-monooxygenase EC 1.13.12.2: lysine 2-monooxygenase EC 1.13.12.3: tryptophan 2-monooxygenase EC 1.13.12.4: lactate 2- ...
Sircar, D.; Mitra, A. (2008). "Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage ... 165 (4): 407-414. doi:10.1016/j.jplph.2007.05.005. PMID 17658659. Portal: Biology v t e (Articles with short description, Short ... In enzymology, a 4-hydroxybenzaldehyde dehydrogenase (EC 1.2.1.64) is an enzyme that catalyzes the chemical reaction 4- ... The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p- ...
p-Hydroxybenzoate hydroxylase (PHBH) catalyzes the oxygenation of p-hydroxybenzoate (pOHB) to 3,4-dihyroxybenzoate (3,4-diOHB ... Cytochrome P450 type enzymes that catalyze monooxygenase (hydroxylation) reactions are dependent on the transfer of two ... Riboflavin FADH2 FMN FMO, flavin-containing monooxygenase NAD Teufel, Robin; Agarwal, Vinayak; Moore, Bradley S. (2016-04-01 ... 5 (3): 533-44. doi:10.1093/mp/sss020. PMID 22431563. Sivabalan S, Vedeswari CP, Jayachandran S, Koteeswaran D, Pravda C, Aruna ...
... cytochrome P450 monooxygenases, and fatty acid monooxygenases, are a set of cytochrome P450-containing enzymes that catalyze ... Schreuder HA, van Berkel WJ, Eppink MH, Bunthol C (1999). "Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. ... The CYP omega hydroxylases are often referred to as monoxygenases; however, the monooxygenases are CYP450 enzymes that add a ... The CYP450 omega hydroxylases are accordingly better viewed as a subset of monooxygenases that have the ability to hydroxylate ...
Renilla-luciferin 2-monooxygenase EC 1.13.12.5 Cypridina-luciferin 2-monooxygenase EC 1.13.12.6 Firefly luciferase EC 1.13.12.7 ... Watasenia-luciferin 2-monooxygenase EC 1.13.12.8 Oplophorus-luciferin 2-monooxygenase EC 1.13.12.13 Cytochrome P450 oxidase ... 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate-CoA ligase EC 6.2.1.42: 3-oxocholest-4-en-26-oate-CoA ... internal monooxygenases or internal mixed function oxidases)) ... EC 1.6.4 now Category:EC 1.8.1 Category:EC 1.6.5 (with a ...
Now included in EC 2.4.1.122, N-acetylgalactosaminide β-1,3-galactosyltransferase EC 2.4.1.308: GDP-Fuc:β-D-Gal-1,3-α-D-GalNAc- ... EC 2.4.2.24: 1,4-β-D-xylan synthase EC 2.4.2.25: flavone apiosyltransferase EC 2.4.2.26: protein xylosyltransferase EC 2.4.2.27 ... 3)-α-D-Gal-PP-Und α-1,3-abequosyltransferase EC 2.4.1.383: GDP-Man:α-L-Rha-(1→3)-α-D-Gal-PP-Und β-1,4-mannosyltransferase EC ... 4)-α-L-Rha-(1→3)-α-D-Gal-PP-Und α-1,3-abequosyltransferase EC 2.4.1.61: deleted, included in EC 2.4.1.17 EC 2.4.1.62: ...
2-dihydroquinoline 6-monooxygenase activity ... 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity GO: ...
p-Hydroxybenzoate Hydroxylase use 4-Hydroxybenzoate-3-Monooxygenase p-Hydroxynorephedrine p-Hydroxyphenyl-orciprenaline use ... P450cam use Camphor 5-Monooxygenase P450RAI use Retinoic Acid 4-Hydroxylase p48 ISGF3gamma use Interferon-Stimulated Gene ... PACAPR 3 Protein use Receptors, Vasoactive Intestinal Peptide, Type II PACAPR-1 Protein use Receptors, Pituitary Adenylate ... p101 Subunit, Phosphoinositide 3 Kinase use Class Ib Phosphatidylinositol 3-Kinase p101 Subunit, Phosphoinositide-3-Kinase use ...
p-Hydroxybenzoate Hydroxylase use 4-Hydroxybenzoate-3-Monooxygenase p-Hydroxynorephedrine p-Hydroxyphenyl-orciprenaline use ... P450cam use Camphor 5-Monooxygenase P450RAI use Retinoic Acid 4-Hydroxylase p48 ISGF3gamma use Interferon-Stimulated Gene ... PACAPR 3 Protein use Receptors, Vasoactive Intestinal Peptide, Type II PACAPR-1 Protein use Receptors, Pituitary Adenylate ... p101 Subunit, Phosphoinositide 3 Kinase use Class Ib Phosphatidylinositol 3-Kinase p101 Subunit, Phosphoinositide-3-Kinase use ...
p-Hydroxybenzoate Hydroxylase use 4-Hydroxybenzoate-3-Monooxygenase p-Hydroxynorephedrine p-Hydroxyphenyl-orciprenaline use ... P450cam use Camphor 5-Monooxygenase P450RAI use Retinoic Acid 4-Hydroxylase p48 ISGF3gamma use Interferon-Stimulated Gene ... PACAPR 3 Protein use Receptors, Vasoactive Intestinal Peptide, Type II PACAPR-1 Protein use Receptors, Pituitary Adenylate ... p101 Subunit, Phosphoinositide 3 Kinase use Class Ib Phosphatidylinositol 3-Kinase p101 Subunit, Phosphoinositide-3-Kinase use ...
p-Hydroxybenzoate Hydroxylase use 4-Hydroxybenzoate-3-Monooxygenase p-Hydroxynorephedrine p-Hydroxyphenyl-orciprenaline use ... P450cam use Camphor 5-Monooxygenase P450RAI use Retinoic Acid 4-Hydroxylase p48 ISGF3gamma use Interferon-Stimulated Gene ... PACAPR 3 Protein use Receptors, Vasoactive Intestinal Peptide, Type II PACAPR-1 Protein use Receptors, Pituitary Adenylate ... p101 Subunit, Phosphoinositide 3 Kinase use Class Ib Phosphatidylinositol 3-Kinase p101 Subunit, Phosphoinositide-3-Kinase use ...
p-Hydroxybenzoate Hydroxylase use 4-Hydroxybenzoate-3-Monooxygenase p-Hydroxynorephedrine p-Hydroxyphenyl-orciprenaline use ... P450cam use Camphor 5-Monooxygenase P450RAI use Retinoic Acid 4-Hydroxylase p48 ISGF3gamma use Interferon-Stimulated Gene ... PACAPR 3 Protein use Receptors, Vasoactive Intestinal Peptide, Type II PACAPR-1 Protein use Receptors, Pituitary Adenylate ... p101 Subunit, Phosphoinositide 3 Kinase use Class Ib Phosphatidylinositol 3-Kinase p101 Subunit, Phosphoinositide-3-Kinase use ...
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease use Tyrosinemias 4-Nitrophenol-2-Hydroxylase use Cytochrome P-450 CYP2E1 ... 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase 3-beta-Hydroxysteroid Dehydrogenase use 3- ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ... 4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease use Tyrosinemias 4-Nitrophenol-2-Hydroxylase use Cytochrome P-450 CYP2E1 ... 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase 3-beta-Hydroxysteroid Dehydrogenase use 3- ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-Glucose use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3-Hydroxy-3-methylglutaric Acid ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 2-PAM Compounds use ...
2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-Glucose use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3-Hydroxy-3-methylglutaric Acid ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 2-PAM Compounds use ...
2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-glucose use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3-Hydroxy-3-methylglutaric Acid ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 2-PAM Compounds use ...
3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone. ... we identify an NADPH/FAD-dependent monooxygenase VibO as the key enzyme performing a crucial ring-expansive oxygenation on the ... 3. A gene expression profile-based approach to screen the occurrence and predisposed host characteristics of drug-induced liver ... Cyclization of 3 forms vibralactone (1) whose ß-lactone-fused bicyclic core originates from 4-hydroxybenzoate, yet it remains ...
Crystal structure of the native monooxygenase domain of MICAL at 1.45 A resolution ... The topology most closely resembles that of the NADPH-dependent flavoenzyme p-hydroxybenzoate hydroxylase (PHBH). Comparison of ... MICAL (molecule interacting with CasL) is a multidomain cytosolic protein with a putative flavoprotein monooxygenase (MO) ... MICAL (molecule interacting with CasL) is a multidomain cytosolic protein with a putative flavoprotein monooxygenase (MO) ...
p-hydroxybenzoate hydroxylase. 任意. MMG1. (NRULE_0029). Multicomponent monooxygenase gamma subunit. ... 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase. ... 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase. ... 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase. ...
1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases) ... 1.13.12.23: 4-hydroxy-3-prenylbenzoate synthase. This is an abbreviated version!. For detailed information about 4-hydroxy-3- ...
P-hydroxybenzoate hydroxylase. * Phenanthrene degradation. * Phthalate esters. * Phthalate Isomers. * Preferential utilization ... Fad-dependent monooxygenase. * Flavin adenine dinucleotide. * flavoprotein hydroxylases. * Gene duplication. * Gene-cluster ...
The P. mendocina KR1 gene encoding p-hydroxybenzoate hydroxylase was linked to, but independently regulated from, the genes ... and a third encoding p-hydroxybenzoate hydroxylase. The last two regulatory units were cloned from the chromosome of a P. ... MeSH Terms: 4-Hydroxybenzoate-3-Monooxygenase/genetics; Aldehyde Oxidoreductases/genetics; Cloning, Molecular; Conjugation, ... one encoding toluene-4-monooxygenase, a second encoding p-cresol methylhydroxylase and p-hydroxybenzaldehyde dehydrogenase, ...
p-Hydroxybenzoate Hydroxylase para-Hydroxybenzoate Hydroxylase Registry Number. EC 1.14.13.2. CAS Type 1 Name. 4- ... Squalene Monooxygenase [D08.811.682.690.708.749] * Trans-Cinnamate 4-Monooxygenase [D08.811.682.690.708.826] ... p-Hydroxybenzoate Hydroxylase Term UI T044129. Date11/11/1974. LexicalTag NON. ThesaurusID UNK (19XX). ... para-Hydroxybenzoate Hydroxylase Term UI T044128. Date05/15/1976. LexicalTag NON. ThesaurusID UNK (19XX). ...
p-Hydroxybenzoate Hydroxylase para-Hydroxybenzoate Hydroxylase Registry Number. EC 1.14.13.2. CAS Type 1 Name. 4- ... Squalene Monooxygenase [D08.811.682.690.708.749] * Trans-Cinnamate 4-Monooxygenase [D08.811.682.690.708.826] ... p-Hydroxybenzoate Hydroxylase Term UI T044129. Date11/11/1974. LexicalTag NON. ThesaurusID UNK (19XX). ... para-Hydroxybenzoate Hydroxylase Term UI T044128. Date05/15/1976. LexicalTag NON. ThesaurusID UNK (19XX). ...
P-Hydroxybenzoate hydroxylase. Code(s) darborescence:. D08.811.682.690.708.425. Identificateur unique RDF:. https://id.nlm.nih ... Dopamine beta-monooxygenase [D08.811.682.690.708.292] Dopamine beta-monooxygenase * Fatty acid desaturases [D08.811.682.690. ... We invite you to complete a survey that will take no more than 3 minutes.. Go to survey ... Contenu principal 1 Le menu 2 Recherche 3 Bas de page 4 ... Trans-cinnamate 4-monooxygenase [D08.811.682.690.708.826] Trans ...
3-Hydroxybenzoate 4-monooxygenase Current Synonym true false 124236014 3-Hydroxybenzoate 4-hydroxylase Current Synonym true ... 3-hydroxybenzoate 4-hydroxylase Current Synonym true false 3721351018 3-hydroxybenzoate 4-monooxygenase Current Synonym true ... 3-hydroxybenzoate 4-monooxygenase (substance). Code System Preferred Concept Name. 3-hydroxybenzoate 4-monooxygenase (substance ...
... a single-component flavoprotein monooxygenase) identified in the moc cluster was found to be necessary and specific for the ... a single-component flavoprotein monooxygenase) encoded by the mocA gene was responsible for the initial hydroxylation of E1. ... providing new insight into the biological role of flavoprotein monooxygenase. ... For all 3 threshold methods applied, 11 C-choline PET/CT produced more consistent and comparable tumor volume to MRI than 18 F- ...
Sodium Salt N0000179250 sorbitan monooleate N0000167872 Squalene Monooxygenase N0000167874 Monophenol Monooxygenase N0000167192 ... Methyl Ethers N0000166836 Glyceryl Ethers N0000167396 Crown Ethers N0000168628 Phospholipid Ethers N0000185689 Hydroxybenzoate ... Monooxygenase N0000169020 Arachidonate 15-Lipoxygenase N0000168717 Syntaxin 16 N0000170033 Steroid 16-alpha-Hydroxylase ... N0000169019 Arachidonate 5-Lipoxygenase N0000170029 Camphor 5-Monooxygenase N0000178662 Mucin 5AC N0000169770 Aquaporin 6 ...
2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-glucose use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3-Hydroxy-3-methylglutaric Acid ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 2-PAM Compounds use ...
Steroid 12-Monooxygenase D8.262.453.820 D8.262.453.915.730 D8.586.682.420.170.820 D8.586.682.580.170.915.730 D8.586.682.420. ... Steroid 17 alpha-Monooxygenase D8.262.453.800 D8.262.453.915.748 D8.586.682.420.170.800 D8.586.682.580.170.915.748 D8.586. ... Steroid 21-Monooxygenase D8.262.453.830 D8.262.453.915.760 D8.586.682.420.170.830 D8.586.682.580.170.915.760 D8.586.682.420. ... Cholesterol Monooxygenase (Side-Chain-Cleaving) D8.262.453.110 D8.262.453.915.212 D8.586.682.420.170.110 D8.586.682.580.170.915 ...
"Squalene Monooxygenase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Squalene Monooxygenase" by people in this website by year, and ... Below are the most recent publications written about "Squalene Monooxygenase" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Squalene Monooxygenase". ...
Human COQ6 encodes a monooxygenase which is responsible for the C5-hydroxylation of the quinone ring of coenzyme Q (CoQ). ... flavin-dependent monooxygenase; pHBH; para-hydroxybenzoate hydroxylase; steroid resistant nephrotic syndrome; vanillic acid. ... Human COQ6 encodes a monooxygenase which is responsible for the C5-hydroxylation of the quinone ring of coenzyme Q (CoQ). ... 3 (A) Growth assay of Δcoq6 cells expressing huCOQ6-isoa, huCOQ6-isob and yCoq6 on LG-pABA medium containing either 10 μM 4HB ...
Ueng T, Hung C, Wang H and Chan P (2004) Effects of amitraz on cytochrome P450-dependent monooxygenases and estrogenic activity ... Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens, Environmental Research, ... Furuta M, Funabashi T, Kawaguchi M, Nakamura T, Mitsushima D and Kimura F (2006) Effects of p-Nonylphenol and 4-tert- ... 3, (592-612). Zoeller R, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd K, Kortenkamp A, ...
","Dimethyl-sulfide monooxygenase [Ensembl]. Luciferase-like monooxygenase [Interproscan].","protein_coding" "CRP17438","sadH_2 ... ","Methane monooxygenase component C [Ensembl]. FAD-binding domain, Oxidoreductase NAD-binding domain, Ferric reductase like ... ","Pseudomonas aeruginosa","(S)-limonene 6-monooxygenase [Ensembl]. PAS fold, Sigma-54 interaction domain, Bacterial regulatory ... ","chitin binding protein [Ensembl]. Lytic polysaccharide mono-oxygenase [Interproscan].","protein_coding" "AEA95207","OG1RF_ ...
  • The topology most closely resembles that of the NADPH-dependent flavoenzyme p-hydroxybenzoate hydroxylase (PHBH). (rcsb.org)
  • For detailed information about 4-hydroxy-3-prenylbenzoate synthase, go to the full flat file . (brenda-enzymes.info)
  • Although the genes encoding the upper pathway for toluene metabolism in P. mendocina KR1 are sufficiently linked to permit their coordinate mobilization, they were found to be encoded in three independently regulated units: one encoding toluene-4-monooxygenase, a second encoding p-cresol methylhydroxylase and p-hydroxybenzaldehyde dehydrogenase, and a third encoding p-hydroxybenzoate hydroxylase. (nih.gov)
  • The P. mendocina KR1 gene encoding p-hydroxybenzoate hydroxylase was linked to, but independently regulated from, the genes encoding toluene-4-monooxygenase, p-cresol methylhydroxylase, and p-hydroxybenzaldehyde dehydrogenase. (nih.gov)
  • A flavoprotein that catalyzes the synthesis of protocatechuic acid from 4-hydroxybenzoate in the presence of molecular oxygen. (nih.gov)
  • Flavoproteína que cataliza la síntesis del ácido protocatechuico a partir de 4-hidroxibenzoato en presencia de oxígeno molecular. (bvsalud.org)