4-Hydroxyaminoquinoline-1-oxide: A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.Nitroquinolines: Quinolines substituted in any position by one or more nitro groups.4-Nitroquinoline-1-oxide: A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.Aminoquinolines: Quinolines substituted in any position by one or more amino groups.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Confined Spaces: A space which has limited openings for entry and exit combined with unfavorable natural ventilation such as CAVES, refrigerators, deep tunnels, pipelines, sewers, silos, tanks, vats, mines, deep trenches or pits, vaults, manholes, chimneys, etc.Occupational Diseases: Diseases caused by factors involved in one's employment.Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Occupational Health Services: Health services for employees, usually provided by the employer at the place of work.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Occupational Medicine: Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Bacteriophage M13: Temperate bacteriophage of the genus INOVIRUS which infects enterobacteria, especially E. coli. It is a filamentous phage consisting of single-stranded DNA and is circularly permuted.Bacteriophages: Viruses whose hosts are bacterial cells.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Coliphages: Viruses whose host is Escherichia coli.Bacteriophage T4: Virulent bacteriophage and type species of the genus T4-like phages, in the family MYOVIRIDAE. It infects E. coli and is the best known of the T-even phages. Its virion contains linear double-stranded DNA, terminally redundant and circularly permuted.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Acrylamide: A colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile. It is primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Air Pollution: The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.Vehicle Emissions: Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)Air Pollutants: Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.X-Ray Intensifying Screens: Screens which absorb the energy in the x-ray beam that has penetrated the patient and convert this energy into a light pattern which has as nearly as possible the same information as the original x-ray beam. The more light a screen produces for a given input of x-radiation, the less x-ray exposure and thus shorter exposure time are needed to expose the film. In most film-screen systems, the film is sandwiched between two screens in a cassette so that the emulsion on each side is exposed to the light from its contiguous screen.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Polycarboxylate Cement: Water-soluble low-molecular-weight polymers of acrylic or methacrylic acid that form solid, insoluble products when mixed with specially prepared ZnO powder. The resulting cement adheres to dental enamel and is also used as a luting agent.Gallium: A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.

Dual effects of prolonged ACTH stimulation on 4-hydroxyaminoquinoline 1-oxide-induced adrenocortical lesions in rats. (1/14)

The effects of a long-acting synthetic ACTH on 4-hydroxyaminoquinoline 1-oxide (4HAQO)-induced adrenocortical lesions were investigated in female rats. A total of 140 6-week-old rats were divided into 4 equal groups, given a single s.c. injection of 7 mg/kg 4HAQO or vehicle, followed by repeated sc administration of the synthetic ACTH or no further treatment. Subgroups of 10 rats in each group were sequentially sacrificed at weeks 20, 30, and 40. Adenomas and adenomatous nodules developed in the adrenal cortex of animals receiving 4HAQO and the chronic ACTH stimulation. Both lesions were located in the deeper zones of the adrenal cortex adjacent to the medulla and were composed of large-sized, clear-type cells. From week 20, middle zone, cortical cystic degeneration, which mimics the age-associated degenerative change named adrenal peliosis, was frequently observed in the adrenal glands of animals treated with 4HAQO alone. Its development was inhibited by ACTH. In the control animals, peliotic changes occurred at low incidence and only at the termination of experiment. These results indicate that long-term stimulation of ACTH promotes the development of adrenocortical tumors but suppresses the occurrence of adrenal peliosis in rats treated with 4HAQO.  (+info)

Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide. (2/14)

The inducibility of pancreatic islet cell tumors by administration of 4-hydroxyaminoquinoline 1-oxide (4HAQO) was investigated in male 6-week-old Sprague-Dawley rats. Rats were given 4HAQO intravenously at a weekly dose of 5 mg/kg 4 times (group 1) or a single dose of 10 mg/kg (group 2). Control rats received the vehicle alone (group 3). Fifty-six weeks after the first 4HAQO administration, all surviving animals were killed and the pancreas was examined histopathologically, immunohistochemically and ultrastructurally. The incidences and multiplicities of islet cell tumors in groups 1, 2, and 3 were 52.3% (p < 0.05 vs group 2, p < 0.01 vs group 3), 19.2% and 0%, and 0.70/animal (p < 0.05 vs group 2, p < 0.01 vs group 3), 0.23 and 0, respectively. Islet cell carcinomas were induced only in group 1, accounting for 6/44 (26%) tumors. Islet cell hyperplasias were found in 61.4% (p < 0.05 vs group 3), 42.3% and 10.0% of groups 1, 2, and 3, with multiplicities of 0.95 (p < 0.05 vs groups 2 and 3), 0.54 and 0.20, respectively. As compared with normal islets from control subjects, islet cell tumors showed an increase in the number of insulin positive cells associated with cytological features indicative of enhanced insulin synthesis and secretion, and a decrease in the number of glucagon positive cells without ultrastructural signs of modified secretory activity. Thus our results indicate that repeated intravenous administration of 4HAQO to rats is useful for the induction of islet cell tumors at high incidence.  (+info)

Sequential alteration of apoptosis, p53 expression, and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide. (3/14)

Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body weight and control rats received vehicle alone and were euthanized after 2-72 hours. Pancreata and livers were removed for histopathological examination, immunohistochemistry for p53 protein, PCNA and Ki-67, and TUNEL labeling and electron microscopic observation for detecting apoptosis. In the pancreas, p53 expression and apoptosis were significantly increased first at 4 and 6 hours, respectively, while no change was evident in the liver. The rates peaked at 24 hours, consistent with the peak for PCNA-labeling, while Ki-67-labeling rates peaked at 72 hours. Electron microscopically, apoptotic changes in pancreatic acinar cells were observed after 2 hours. No significant apoptosis, p53 expression or cell proliferation were noted in the pancreatic tissues of the control rats nor in liver cells regardless of 4HAQO treatment. Taken together with our previous data, the results suggest that apoptosis, p53 expression, and enhanced cell replication are closely related phenomena involved in the carcinogenesis of 4HAQO following DNA adduct formation.  (+info)

The FLP protein contacts both major and minor grooves of its recognition target sequence. (4/14)

The FLP protein of the 2 microns plasmid of Saccharomyces cerevisiae promotes conservative site-specific recombination between DNA sequences that contain the FLP recognition target (FRT). FLP binds to each of the three 13 base pair symmetry elements in the FRT site in a site-specific manner. We have probed both major and minor groove contacts of FLP using dimethyl sulphate, monoacetyl-4-hydroxyaminoquinoline 1-oxide and potassium permanganate and find that the protein displays extensive interactions with residues of both the major and minor grooves of 10 base pairs of each symmetry element. We find no evidence that the FRT site assumes a single-stranded conformation upon FLP binding.  (+info)

Interaction of RecA protein with pBR322 DNA modified by N-hydroxy-2-acetylaminofluorene and 4-hydroxyaminoquinoline 1-oxide. (5/14)

Interaction of RecA protein of Escherichia coli with pBR322 DNA modified by N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and 4-hydroxyaminoquinoline 1-oxide (4HAQO) was investigated. RecA protein bound more efficiently to modified DNA than to unmodified DNA as judged by filter-binding and gel electrophoresis assay. The binding of RecA protein with modified DNA resulted in the stimulation of ATPase activity and the activation for RecA protein to stimulate the repressor cleavage. These abilities of RecA protein were increased proportionally to the number of adducts in the plasmid DNA (0-5 adducts). Apurinic and alkylated DNA did not activate RecA protein. We suggest that modification of DNA by N-OH-AAF and 4HAQO provides binding sites for RecA protein and may act as an activation signal for SOS response.  (+info)

5-Chloro-7-iodo-8-hydroxyquinoline (clioquinol) inhibits the nerve growth factor-induced stimulation of RNA synthesis in neonatal rat superior cervical ganglion, in vitro--comparison with effects of methylmercuric chloride and 4-hydroxyaminoquinoline-N-oxide. (6/14)

The inhibitory effects of 5-chloro-7-iodo-8-hydroxy-quinoline (clioquinol), methylmercuric chloride and 4-hydroxyaminoquinoline-N-oxide(4-HAQO) on DNA, RNA and protein syntheses in the neonatal rat superior cervical ganglion (SCG) were studied in relation to the action of mouse 2.5S nerve growth factor (NGF), using organ cultures. RNA and protein syntheses in SCG were stimulated approximately 3- and 2-fold, respectively, by NGF (1 microgram/ml), but the DNA synthesis was only slightly or not at all stimulated. Methylmercuric chloride and 4-HAQO dose-dependently inhibited DNA, RNA and protein syntheses, either in the presence or in the absence of NGF. On the other hand, clioquinol (up to 100 microM) slightly or not at all inhibited RNA synthesis in the absence of NGF; however, it did abolish the NGF-induced stimulation of RNA synthesis in the presence of NGF. The DNA and protein syntheses were dose-dependently inhibited by clioquinol, either in the presence or in the absence of NGF. We conclude from this study that the interaction between clioquinol and the functions of NGF raises the question of a possible toxicity of the drug on specific neurons.  (+info)

In vivo studies on age dependency of DNA repair with age in mouse skin. (7/14)

Since the capacity for DNA repair relative to other cellular processes is an important parameter relevant to mutagenesis, carcinogenesis, and also aging, its assessment should preferably be carried out in intact animals. For this reason we developed an autoradiographic technique for measuring DNA repair directly in vivo. By this method unscheduled DNA synthesis (UDS) can be detected quantitatively as silver grains over epithelial cells of mouse skin after treatment with chemical carcinogens or ultraviolet (UV) irradiation. Possible age-related change in UDS response was examined by this skin technique using 2- and 18-mo-old mice. Similar dose-dependent induction of UDS was observed in mice of both ages after treatment with 4-hydroxyaminoquinoline 1-oxide. The dose-response curves for young and aged animals after UV irradiation also showed similar increases to a plateau level at low doses, but their responses to high doses were very different. In aged mice the UDS level decreased markedly with increase in dose, whereas in young mice it remained at the same plateau level. This suggests that, in aged animals, high doses of UV irradiation cause deterioration of DNA repair systems, and that aged animals cannot repair extensive UV-induced DNA damage efficiently.  (+info)

Adducts from in vivo action of the carcinogen 4-hydroxyaminoquinoline 1-oxide in rats and from in vitro reaction of 4-acetoxyaminoquinoline 1-oxide with DNA and polynucleotides. (8/14)

In vivo 4-hydroxyamino[2-3H]quinoline 1-oxide-modified DNA and in vitro 4-acetoxyamino[2-3H]quinoline 1-oxide-modified DNA were enzymatically hydrolyzed, and the hydrolysates were analyzed by high-performance liquid chromatography. The two patterns were compared, and we showed that all of the high-performance liquid chromatography peaks which were recovered from in vivo-modified DNA were present in the hydrolysate of in vitro-modified DNA. Therefore, we used the in vitro 4-acetoxyamino[2-3H]quinoline 1-oxide-modified DNA to investigate the quinoline-purine adducts which are characteristics of the mode of action of the carcinogen 4-nitroquinoline 1-oxide. By comparison with the enzymatic hydrolysates of 4-acetoxyamino[2-3H]quinoline 1-oxide-modified covalent poly(deoxyadenylate-deoxythymidylate) X poly(deoxyadenylate-deoxythymidylate) and covalent poly(deoxyguanylate-deoxycytidylate) X poly(deoxyguanylate-deoxycytidylate) three nitroquinoline adducts were enumerated on the modified DNA. One of them was previously characterized as a C8-guanyl adduct. We proved that the two other are a guanine and an adenine adduct, respectively. A quinoline derivative was identified in the hydrolysates of the in vivo- and in vitro-modified DNAs as 4-aminoquinoline 1-oxide, the origin of which was postulated to be a degradation compound of one (or more) adduct(s). Moreover, the presence of two degradation compounds of the C8-guanyl adduct was shown in mild alkaline conditions. We suspected an imidazole ring-opened form.  (+info)

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Studies on the disposion of [^,14,C]NB-506 : Plasma Concentration-Time Profile, Distribution, Metabolism and Excretion of [^,14,C]NB-506 after Single and Repeated Intravenous Administration in Rats (1998 ...
Animal work. Diabetic db/db, mice and their control littermates db/m were obtained from The Jackson Laboratory (strain: BKS.Cg-Dock7m+/+Leprdb/J) and bred in-house. All animals were maintained on a normal chow diet with free access to water and housed in a room with a 12-hour light/12-hour dark cycle and an ambient temperature of 22°C. Type 1 diabetes was induced in mice as previously described (13). Drp1S600A-knockin mice. We designed a Drp1S600A-knockin construct using a replacement targeting strategy that involved 3 cloning steps. First, a 3.5-kb genomic DNA encompassing exons 15-17 and the proximal intronic regions of the Drp1 gene was PCR amplified and subcloned directly into a pLNTK vector. This DNA fragment was sequencing verified and used as the 5′ homologous recombination arm. Second, a neomycin-resistant minigene cassette flanked by flippase recognition target (FRT) sequences was added to the 3′ end of the 5′ arm in the pLNTK backbone. Third, a 5.1-kb genomic fragment ...
Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the development and maintenance of paclitaxel-induced peripheral neuropathy are still unclear, and there are no currently established effective treatments. Accumulating evidence in models of neuropathic pain in which peripheral nerves are lesioned has implicated spinal microglia and chemokines in pain hypersensitivity, but little is know about their roles in chemotherapy-induced peripheral neuropathy. In the present study, we investigated the role of CC-chemokine ligand 3 (CCL3) in the spinal cord in the development and maintenance of mechanical allodynia using a rat model of paclitaxel-induced neuropathy. Repeated intravenous administration of paclitaxel induced a marked decrease in paw withdrawal threshold in response to mechanical stimulation (mechanical allodynia). In these rats, the number of microglia in
In different studies, the given test chemical has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents, i.e. most commonly in rats and mouse for test chemical. The studies are summarized as below - 1) In acute oral toxicity study, rats were treated with test chemical at a concentration of 937 - 2135 mg/kg bw orally. 50% mortality was observed at 1297 mg/kg bw in treated rat. Therefore, LD50 was considered to be 1297 mg/kg bw with 95% confidence limits (937 -2135) when rats were treated with test chemical orally and the test chemical can be classified as acute oral toxic category 4 as per CLP regulation. 2) In acute oral toxicity study, rats were treated with test chemical at a concentration of 1300 mg/kg bw orally. 50% mortality was observed at 1300 mg/kg bw in treated rat. Therefore, LD50 was considered to be 1300 mg/kg bw when rats were treated with test chemical orally and the test chemical can be classified as ...
They are present in soil, water and air, and exist in products used daily at home, at work and in our vehicles. So its no surprise that many end up in our ...
We have investigated whether there is evidence of target-directed growth of retinal axons to the tectum, and whether the surface of the rostral brainstem is an obligatory substrate for growing optic axons by transplanting embryonic mouse retinae to the cerebral aqueduct of neonatal rats. Such retinae emit axons that grow dorsally through the brain parenchyma to reach the superficial layers of the superior colliculus either by running dorsally along the midline, or by following a dorsally directed, radially arching course through the brain parenchyma. Studies of the early outgrowth pattern from transplanted retinae, and comparison studies of the axonal outgrowth from similarly placed cortical grafts suggest that outgrowth of retinal axons is target-directed and specific to optic axons.
Hydrolysis Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below: The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C (ranges from 49-51°C) and pH of 4, 7 and 9, respectively. Initial test chemical concentration used for the study was 100 mg/l. Experiment was performed in 2 replicates. The test substance has no activity of hydrolysis and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of50⁰C for 5 days. The half-life value of test chemical was determined to be , 5 days at pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable. In an another study, the half-life and hydrolysis rate constant was determined of the ...
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This Test Guideline describes a method to estimate the developmental toxicity of a test chemical to the dung dwelling life stages of dung-dependent dipteran species. Two test species can be used. The test chemical is mixed with bovine faeces, to which either 10 eggs of Scathophaga stercoraria or 10 larvae of Musca autumnalis are added. The test will be terminated 5 days after emergence of the last adult in the control (> 18 days for S. stercoraria, >13 days for M. autumnalis). Then the possible impacts of the test chemical on the following measurement endpoints are assessed under controlled conditions: sex and total number of emerged adult flies, retardation of emergence indicated by the developmental rate and morphological change. Depending on the experimental design, the No Observed Effect Concentration (NOEC) or the Effect concentration for x percent effect (ECx) can be determined. This Guideline can be used for water soluble or insoluble substances, but is not
The European Joint Research Center (JRC) has released a new strategy on how to replace, reduce and refine the use of fish in testing of chemicals eff...
0093]As the water-soluble polymer which can be jointly used other than the above-mentioned PVA-based resin, there may be mentioned unmodified PVA, carboxyl group-containing PVA, formalized, acetalized, butyralized or urethanated PVA, PVA of an esterificated product and the like with sulfonic acid, carboxylic acid or the like and acetoacetylated PVA, diacetoneacrylamide-modified PVA, PVA with Thiol end group, PVA in which amount of the main chain 1,2-glycol bond obtained by high temperature high pressure polymerization is 1.8% by mol or more, ethylene oxide-modified PVA, a saponification product of copolymer of a vinyl ester with a monomer copolymerizable therewith, and the like. As the monomer copolymerizable with a vinyl ester, there may be mentioned olefins such as ethylene, butylene, isobutylene, α-octene, α-dodecene and α-octadecene, unsaturated acids such as acrylic acid, methacrylic acid, crotonic acid, maleic acid, maleic anhydride or itaconic acid or salts or mono- or dialkyl esters ...
The modifying effects of two natural products, curcumin and hesperidin, given during the initiation and postinitiation phases of oral carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats and compared with that of β-carotene. At 6 weeks of age, rats were divided into experimental and control groups and fed the diet containing β-carotene, hesperidin, or curcumin at a dose of 0.5 g/kg diet (500 ppm). At 7 weeks of age, all animals except those treated with each test chemical alone and control groups were given 4-NQO (20 ppm) in the drinking water for 8 weeks to induce oral cancer. Seven days after the 4-NQO exposure, groups of animals fed the diets containing test chemicals were switched to the basal diet and continued on this diet until the end of the study. Starting 1 week after the stop of 4-NQO exposure, the groups given 4-NQO and a basal diet were switched to the diets containing β-carotene, hesperidin, and curcumin and maintained on these diets ...
Author(s): Zoran Erlic, Ursula Ploeckinger, Alberto Cascon, Michael M Hoffmann, Laura von Duecker, Aurelia Winter, Gerit Kammel, Janina Bacher, Maren Sullivan, Berend Isermann, Lars Fischer, Andreas Raffel, Wolfram Trudo Knoefel, Matthias Schott, Tobias Baumann, Oliver Schaefer, Tobias Keck, Richard P Baum, Ioana Milos, Mihaela Muresan, Mariola Peczkowska, Andrzej Januszewicz, Kenko Cupisti, Anke Tönjes, Mathias Fasshauer, Jan Langrehr, Peter von Wussow, Abbas Agaimy, Günter Schlimok, Regina Lamberts, Thorsten Wiech, Kurt Werner Schmid, Alexander Weber, Mercedes Nunez, Mercedes Robledo, Charis Eng, Hartmut P H Neumann, , Journal: ...
The permeation of films and membranes can be measured with any gas or liquid. One method uses a central module which is separated by the test film: the testing gas is fed on the one side of the cell and the permeated gas is carried to the detector by a sweep gas. The diagram on the right shows a testing cell for films, normally made from metals like stainless steel. The photo shows a testing cell for pipes made from glass, similar to a Liebig condenser. The testing medium (liquid or gas) is situated in the inner white pipe and the permeate is collected in the space between the pipe and the glass wall. It is transported by a sweep gas (connected to the upper and lower joint) to an analysing device. Permeation can also be measured through intermittent contact. This method involves taking a sample of the test chemical and placing it on the surface of the material whose permeability is being observed while adding or removing specific amounts of the test chemical. After a known amount of time, the ...
3-Nitroquinoline 1-oxide | C9H6N2O3 | CID 81935 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
penta(meth)acrylates such as dipentaerythritol hydroxy penta (meth)acrylate and caprolactone-modified dipentaerythritol hydroxy penta(meth)acrylate; tetra(meth)acrylates such as di-trimethylolpropane tetra(meth)acrylate, pentaerythritol tetra(meth)acrylate, pentaerythritol ethoxy-modified tetra(meth)acrylate, di-pentaerythritol hexa(meth)acrylate, di-pentaerythritol penta(meth)acrylate, and tetramethylol methane tetra(meth)acrylate; tri(meth)acrylates such as trimethylolpropane tri(meth)acrylate, tris-ethoxylated trimethylolpropane tri(meth)acrylate, pentaerythritol tri(meth)acrylate, ethoxylated pentaerythritol tri(meth)acrylate, tris (2-(meth)acryloyloxyethyl)isocyanurate, aliphatic hydrocarbon-modified trimethylolpropane tri(meth)acrylate with carbon number of 2 to 5, and isocyanuric acid ethylene oxide-modified tri(meth)acrylate; di(meth)acrylates such as triethylene glycol di(meth)acrylate, diethylene glycol di(meth)acrylate, 1,3-butylene glycol di(meth)acrylate, 1,4-butanediol ...
The incidence of new diagnosed patients with NET of the digestive tract including carcinoid and pancreatic islet cells tumors ranges from 2 to 10 per 100,000 in the western Countries (Kulke M, Mayer R. N Engl J Med 340:858-868, 1999). Despite of the low incidence, the prevalence of these tumors is high because of their relatively long survival estimated in 35% at 5 years for those patients with well or moderate differentiated tumors (Yao JC, et al. J Clin Oncol. 2008;26:3063-3072). In fact, digestive NETs are the second most prevalent tumors derived from the digestive tract after colorectal carcinoma.. NETs are characterized by abundant vasculature, moreover VEGFR and VEGFR are overexpressed in 60-84% of the carcinoids and pancreatic islet cells NETs (Zhang et al. Cancer 2007;109:1478-1486). Other pro-angiogenic factors like the platelet derived growth factor (PDGFR) have been also involved in NET progression and development (Chaudhry A, et al.Cancer Res 1992;52:1006-12).. Pazopanib is an oral ...
The incidence of new diagnosed patients with NET of the digestive tract including carcinoid and pancreatic islet cells tumors ranges from 2 to 10 per 100,000 in the western Countries (Kulke M, Mayer R. N Engl J Med 340:858-868, 1999). Despite of the low incidence, the prevalence of these tumors is high because of their relatively long survival estimated in 35% at 5 years for those patients with well or moderate differentiated tumors (Yao JC, et al. J Clin Oncol. 2008;26:3063-3072). In fact, digestive NETs are the second most prevalent tumors derived from the digestive tract after colorectal carcinoma.. NETs are characterized by abundant vasculature, moreover VEGFR and VEGFR are overexpressed in 60-84% of the carcinoids and pancreatic islet cells NETs (Zhang et al. Cancer 2007;109:1478-1486). Other pro-angiogenic factors like the platelet derived growth factor (PDGFR) have been also involved in NET progression and development (Chaudhry A, et al.Cancer Res 1992;52:1006-12).. Pazopanib is an oral ...
Clioquinol topical fights bacteria and prevents fungus from growing on your skin. Hydrocortisone is a topical steroid. It reduces the actions of chemicals in the body that cause inflammation. Clioquinol and hydrocortisone is a combination medicine used to treat skin infections caused by fungus (such as ringworm or jock...
New research suggests that when a test chemical is activated by estrogen receptors, it effectively converted bad white fat to metabolism-raising good brown fat in mice.
Pfizer announced results from a randomized phase III trial of sunitinib malate (Sutent) in patients with advanced pancreatic islet cell (neuroendocrine) tumors 1
A bioassay of daminozide, a plant growth regulator, for possible carcinogenicity was conducted by administering the test chemical in the diet to Fischer 344 rats and B6C3F1 mice.. Groups of 50 rats and 50 mice of each sex were administered daminozide at one of two doses, either 5,000 or 10,000 ppm, for 104 weeks, then observed for an additional week. Matched controls consisted of 20 untreated males and 20 untreated females of each species. All surviving rats and mice were killed at 105 weeks.. Mean body weights of the high-dose female mice were appreciably lower than those of the corresponding controls, while mean body weights of all other dosed groups of rats and mice were essentially unaffected. No other clinical signs related to administration of daminozide were observed. Sufficient numbers of animals in all groups of rats and mice were at risk for development of late-appearing tumors.. In the male rats, no tumors occurred at incidences that were significantly higher in dosed groups than in ...
The thinking of the older toddler is definitely more advanced than that of the infant or adolescent toddler, who views the set as a series of objects. Such interactions can reflect the adeptness of a toxicant to aid a metabolic pathway that is involved in the bioacti- vation of the co-administered toxicant, thereby resulting in greater cubicle mistreatment before the toxic metabolite. Am Rev Respir Orcus 1987;135:86974 van de Garde EM, Hak E, Souverein PC, et al viagra 75mg free shipping impotence etymology. In vivo punch of chronic management of vasoactive intestinal peptide on gut-associated lymphoid tissues in rats. In the future, to perceive deleterious effects on gamete forming, test chemicals are repeatedly administered to mans and female animals with a view between 2 and 6 weeks in duration last to mating. alone the reference outgo of medically treating low is galactic discount penegra 100 mg visa androgen hormone 3 ep. They may occurrence more infections during the premier 1 to 2 years ...
Comprehensive disease interaction information for clioquinol/hydrocortisone/pramoxine topical. Includes Topical Corticosteroids - Diabetes.
Pancreatic islet cell tumors (ICTs) occur as sporadic neoplasias or as a manifestation of multiple endocrine neoplasia type 1 (MEN1) and von Hippel-Lindau disease (VHL). Molecular classification of ICTs is mandatory for timely diagnosis and surveillance. Systematic comparison of VHL-ICTs and sporadic ICTs has been lacking. Our registry-based approaches used the German NET-Registry with 259 patients with neuroendocrine tumors (NETs), who were primarily diagnosed with NETs, and the German VHL-Registry with 485 molecular genetically confirmed patients who had undergone magnetic resonance imaging or computed tomography of the abdomen. All patients provided blood DNA for testing of the MEN1 and VHL genes for intragenic mutations and large deletions. In the NET-Registry, 9/101 patients (8.9%) with ICTs had germline mutations, 8 in MEN1 and 1 in VHL. In the VHL-Registry, prevalence of NETs was 52/487 (10.6%), and all were ICTs. Interestingly, of those with VHL p.R167W, 47% developed ICTs, compared to ...
3-(Chloromethyl)pyridine hydrochloride is an intermediate that has been proposed for use in the synthesis of agricultural, pharmaceutical, and veterinary chemicals.. A bioassay of 3-(chloromethyl)pyridine hydrochloride for possible carcinogenicity was conducted by administering the test chemical by gavage to Fischer 344 rats and B6C3F1 mice.. Groups of 50 rats and 50 mice of each sex were administered 3-(chloromethyl)pyridine hydrochloride in a vehicle of distilled water three times per week at one of the following doses, either 75 or 150 mg/kg body weight for the rats and either 100 or 200 mg/kg body weight for the mice. The low-dose rats were dosed for 103 weeks and the low-dose mice for 102 weeks. Because of early deaths in the high-dose animals, the high-dose rats were dosed for only 83 weeks and the high-dose mice for only 81 weeks. Controls consisted of groups of 20 rats and 20 mice of each sex which were administered the vehicle only for 104 weeks. All surviving rats and mice were killed ...
4-Nitroquinoline 1-oxide (4NQO)-sensitive mutants of Salmonella typhimurium were found to be sensitive to ultraviolet light (UV) and β-propiolactone. These mutants were subdivided into two groups: host cell reactivation minus (hcr̄) mutants lacking repair activity for the UV-damaged superinfecting phage and recombination-deficient (rec-) mutants. The hcr̄ mutant is known to lack an enzyme to excise pyrimidine dimers formed in UV-irradiated DNA.. 4NQO, β-propiolactone, and UV induced prophages from hcr̄ and wild-type strains but not from rec̄ strains. Prophage induction from hcr̄ strains was far more efficient than that from wild-type strain.. A metabolic intermediate of 4NQO, 4-hydroxylamino-quinoline 1-oxide (4HAQO), which is highly carcinogenic, inactivated Salmonella phage P22 in vitro whereas 4NQO did not. When 4HAQO-treated P22 was assayed simultaneously on hcr̄, rec̄, and wild-type strains lysogenic for P221b, no difference in inactivation rates on these indicator hosts was found. ...
Causes of Toxic polyneuropathy - Clioquinol including triggers, hidden medical causes of Toxic polyneuropathy - Clioquinol, risk factors, and what causes Toxic polyneuropathy - Clioquinol.
SUMMARY. Plastics are nowhere near as safe as you might think. Under the 1976 Toxic Sub-stances Control Act, the US EPA only tests chemicals when it is provided evidence of harm; the EPA has essentially allowed the chemicals industry to regulate itself for the other 60,000+ chemicals on the market. Even in the food industry, federal agencies dont strictly regulate plastics; what is declared a "safe" plastic today may change tomorrow, and "BPA-free" plastic might be made with substances that are even worse than BPA (see below). I would suggest replacing all plastic in your life when reasonably possible. Sometimes there is no reasonable alternative, but often there is.. Why should we care that so many household items are made out of plastic?. On an environmental level, plastics are often made from crude oil. Politically, reliance on crude oil leads to twisted relationships with some of the worlds worst actors. Environmentally, there are direct negative impacts from drilling for crude oil on ...
What to do: Studies indicate even low levels of alcohol consumption increase prostate and many other cancers so no level of consumption is safe with it comes to cancer. While moderate alcohol consumption does appear to be mildly cardioprotective, the American Heart Association does not recommend alcohol intake because it increases the risk of "high blood pressure, obesity, stroke, accidents, suicide, and cancer". It recommends that if you drink alcohol, do so in moderation. This means an average of one to two drinks per day for men and one drink per day for women. A drink is defined as one 12 oz. beer, 4 oz. of wine, 1.5 oz. of 80-proof spirits, or 1 oz. of 100-proof spirits. Additionally, to help prevent prostate cancer, consume a healthy diet thats lower in meat and total fat and rich in a variety of fruits and vegetables (especially berries, tomatoes, and cruciferous vegetables such as cabbage and broccoli), beans and legumes, and omega-3 rich fish such as salmon. ...
... polyvinylpyridine n-oxide MeSH D03.383.725.762 --- pyridinium compounds MeSH D03.383.725.762.232 --- cetylpyridinium MeSH ... 4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438.834.850 --- ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 --- epirizole MeSH D03.383.129.539.487 ...
... polyvinylpyridine n-oxide MeSH D02.455.326.271.884.533.699 --- povidone MeSH D02.455.326.271.884.533.710 --- povidone-iodine ... ethylene oxide MeSH D02.355.291.411.900 --- trichloroepoxypropane MeSH D02.355.291.705 --- okadaic acid MeSH D02.355.291.852 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ...
... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O ⇌ {\displaystyle \rightleftharpoons } 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 ... hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO ... In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction 4-( ... On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi. 24: 423-432. Stanley JS, York JL, Benson AM (1992 ...
... (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
Testing Status of 4-Hydroxyaminoquinoline-1-oxide 11211-S. CASRN: 4637-56-3. Formula: C9-H8-N2-O2. Synonyms/Common Names. *N- ... 4-OH-Aminoquinoline-1-OX. Known Uses. Reasonably anticipated to be a human carcinogen based upon its use as a prototypical ... 2): 1-251.. *Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon ...
Hierarchical zinc oxide/reduced graphene oxide composite: Preparation route, mechanism study and lithium ion storage. ... A novel and simple approach to preparing hierarchical zinc oxide/reduced graphene oxide (ZnO/[email protected]) composite is demonstrated ... Nitric Oxide. A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC ... Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates ...
... oxide; 4-Quinolinamine, N-hydroxy-, 1-oxide; Quinoline, 4-(hydroxyamino)-, 1-oxide; [ChemIDplus] 4-Quinolinamine-N-hydroxy-1- ... Hydroxyamino)quinoline 1-oxide; 4-(Hydroxyamino)quinoline-1-oxide; 4-Hydroxyaminoquinoline N-oxide; 4HAQO; Hydroxylamine, N-(4- ... oxide; 4-Quinolinamine, N-hydroxy-, 1-oxide; Quinoline, 4-(hydroxyamino)-, 1-oxide; [ChemIDplus] 4-Quinolinamine-N-hydroxy-1- ... Hydroxyamino)quinoline 1-oxide; 4-(Hydroxyamino)quinoline-1-oxide; 4-Hydroxyaminoquinoline N-oxide; 4HAQO; Hydroxylamine, N-(4- ...
... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. Other name(s): 4-nitroquinoline ... Accepted name: nitric oxide reductase (cytochrome c). Reaction: nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ... EC 1.7.2.3 trimethylamine-N-oxide reductase (cytochrome c). EC 1.7.2.4 nitrous-oxide reductase. EC 1.7.2.5 nitric oxide ... Accepted name: nitric oxide reductase (menaquinol). Reaction: 2 nitric oxide + menaquinol = nitrous oxide + menaquinone + H2O. ...
... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O ⇌ {\displaystyle \rightleftharpoons } 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 ... hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO ... In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction 4-( ... On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi. 24: 423-432. Stanley JS, York JL, Benson AM (1992 ...
Two other HCAs, 3-amino-1,4-dimethyl-5H-pyriod[4,3-b]indole (Trp-P-1) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline ( ... Multipotential carcinogenicity of the fried food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Jpn J Cancer Res 1985 ... Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its n-hydroxy ... The study population was 97% Caucasian (Table 1). The mean ages of the cases and controls were 65.4 and 66.0 years, ...
4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
Oxidation of Sulfhydryl Compounds in Vitro by 4-Hydroxyaminoquinoline-1-oxide, a Carcinogenic Metabolite of 4-Nitroquinoline-1- ... oxide. Motoo Hozumi, Sunako Inuzuka and Takashi Sugimura. Cancer Res August 1 1967 27 (8 Part 1) 1378-1383; ...
1. Angiogenesis is a crucial event not only for the establishment of secondary growths but also the allow the primary tumor to ... 3. Mutations of p53 in exon 7 were detected in J.H.2-OS,but not in J.H.1-OS,irrespective of the metastatic potentials. Direct ... We have maintained two transplantable rat osteosarcomas, J.H.1-OS is spontaneous osteosarcoma and J.H.2-OS is induced by 4-HAQO ... Publications] A.Kido: p53 mutation and absence of mdm2 amplification and Ki-ras mutation in 4-hydroxyamino quinoline 1-oxide ...
1 This investigation was supported in part by Grants CA 13747, CA 19283, and CA 15901 awarded by the National Cancer Institute ... Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells. Marie E. Varnes and ... The carcinogen 4-nitroquinoline 1-oxide (4-NQO) was found to rapidly deplete non-protein thiols (NPSH) from Ehrlich ascites ... The NPSH thus appeared to play a significant role in 4-NQO detoxification. Glutathione, when present in culture medium during 4 ...
The fd phage and a peptide derived from its p8 coat protein interact with the HIV-1 Tat-NLS and inhibit its biological ... Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse ... Base-specific damage induced by 4-thiouridine photosensitization with 334-nm radiation in M13 phage DNA. Ito, A., Robb, F.T., ... Arrest of DNA elongation by DNA polymerases at guanine adducts on 4-hydroxyaminoquinoline 1-oxide-modified DNA template. ...
1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate... ... Myles, A., And Brown, G. B., 1969, Purine N-oxides. Xxx. Biochemical studies of the oncogen 3-hydroxyxanthine, J. BioL Chem. ... Martin, C. N., And Garner, R. C., 1977, Aflatoxin B1 oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes ... guanine-3-N-oxide and some related compounds, Cancer Res. 30: 184.PubMedGoogle Scholar ...
4-NQO-induced total apoptotic cells were about 12% over the control which was significantly brought down to 3.5% by ... However, the 4-NQO-induced MnPCEs reduced by ARE were found to be dose dependent and consistently significant (. ). ... However, the 4-NQO-induced MnPCEs reduced by ARE were consistently significant (. ). PCE/NCE ratio also significantly decreased ... Group 1 was used as a control which was fed with distilled water orally. Group 2 was fed orally with 400 mg/kg bw of ARE for ...
... prevention of DNA from oxide damage, suppression of cell proliferation, induction of cell apoptosis, and/or downregulation of ... c-h, 4-NQO coincubated with L.salivarius REN (1 × 109 cfu/mL) for 1 to 12 hours. B, LC-MS of 4NQO treated with L.salivarius REN ... Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide. Ming Zhang, Fang Wang, Lu Jiang, ... 1. From week 2, rats in groups 1 to 9 were given 20 ppm 4NQO in drinking water for 8 weeks. Groups 2 to 7 were administered ...
1,3,7-Trimethylxanthine *Vivarin Last updated: 17 November 1997 See Also: Toxicological Abbreviations Caffeine (ICSC) ... Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 5. Summary of Data Reported and Evaluation. 5.1 Exposure data. Caffeine ... Caffeine did not influence the incidence of bladder tumours induced in rats by N-nitroso-N-butyl(4-hydroxybutyl)amine in three ... experiments or of pancreatic tumours induced in rats by 4-hydroxyaminoquinoline-1-oxide in another study. 5.3 Human ...
... oxide‐induced ultrastructural changes in the guinea‐pig exocrine pancreas. Rao, M. S. & Reddy, J. K., Jan 1 1976, In : The ... hydroxyaminoquinoline1‐ ... Rao, M. S. & Reddy, J. K., Jan 1 1977, In : Neoplasma. 24, 1, p ... Rao, M. S. & Reddy, J. K., Jan 1 1977, In : Journal of the National Cancer Institute. 58, 2, p. 387-392 6 p.. Research output: ... Moody, D. E., Rao, M. S. & Reddy, J. K., Dec 1 1977, In : Virchows Archiv B Cell Pathology. 23, 1, p. 291-296 6 p.. Research ...
Naaman, A. E. & Shah, S. P., Jan 1 1976, In : ASCE J Struct Div. 102, 8, p. 1537-1548 12 p.. Research output: Contribution to ... Azzouz, A. S., Krizek, R. J. & Corotis, R. B., Jan 1 1976, In : Soils and Foundations. 16, 2, p. 19-29 11 p.. Research output: ... Reddy, J. K., Rao, M. S. & Jago, M. V., Jan 1 1976, In : International Journal of Cancer. 17, 5, p. 621-625 5 p.. Research ... Wu, D., Denes, P., Dhingra, R. C., Wyndham, C. R. & Rosen, K. M., Jan 1 1976, In : Unknown Journal. 39, 5, p. 659-665 7 p.. ...
7-chloro-4-(hydroxyamino)-, 1-oxide, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other ... 1S/C9H7ClN2O2.ClH/c10-6-1-2-7-8(11-13)3-4-12(14)9(7)5-6;/h1-5,11,13H;1H. Download. ... Substance Name: Quinoline, 7-chloro-4-(hydroxyamino)-, 1-oxide, hydrochloride. RN: 16939-80-3. InChIKey: WEFBFRBNXOXZGH- ...
10b-oxide. 138857-19-9 anti-4,5-dihydroxy-6,6a-epoxy-4,5,6,6a-tetrahydrobenzo[j]fluoranthene ... n,n -[ 6-( 5- nitro-2-furyl)-s-triazine- 2,4-diyl]bisacetamide ...
... oxide (4‐HAQO; 0.1 to 0.3 μg/ml) relative to uninfected cells treated with 4‐HAQO alone. No increase in the percentage of ... hydroxyaminoquinoline1oxide (4‐HAQO; 0.1 to 0.3 μg/ml) relative to uninfected cells treated with 4‐HAQO alone. No increase in ... oxide (4‐HAQO; 0.1 to 0.3 μg/ml) relative to uninfected cells treated with 4‐HAQO alone. No increase in the percentage of ... oxide (4‐HAQO; 0.1 to 0.3 μg/ml) relative to uninfected cells treated with 4‐HAQO alone. No increase in the percentage of ...
kyselina 4-aminobenzoová A member of the VITAMIN B COMPLEX. It used to be common in SUNSCREENING AGENTS until found to also be ... 4-butyrolakton One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma ... 4-aminopyridin One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a ... 4-hydroxyaminochinolin-1-oxid A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds ...
Foxton R, Pereira P, Masatoshi N, Tagami J, Miura H. Long-term durability of the dual-cure resin cement/silicon oxide ceramic ... endothelin 1 products*Clock products*Tnfsf11 products*Dppa3 products*ORC1 products*ASC products*Lep products*Ptgs2 products* ... or a combination of primer/bonding agent on the long-term durability of the dual-cure resin cement/silicon oxide ceramic bond ... 2007;30:791-4 pubmed ..The contribution of the anti-oxidative effect of MT to the anti-stroke effect of Cilostazol was ...
Role of nitric oxide in the control of coronary resistance in teleosts. Seven cows that had given negative rectal swabs at ... Mutagenic activity of 4-nitroquinoline 1-oxide and 4-hydroxyaminoquinoline 1-oxide in Neurospora crassa. Therefore, in the ... Hypoxia inducible factor-1 (HIF-1) regulates transactivation of several genes in response to hypoxia condition. ... It is caused by the formation of pathogenic antibodies to complexes of platelet factor-4 (PF4) and heparin on platelet surfaces ...
Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in ... exposure of cells to nitric oxide (NO), or in response to balloon catheter injury in vivo. ... The mean annual incidence of possible CH showed a gradual increase over the years (1:888 in 2008, 1:592 in 2009, and 1:469 in ... Among the T-tropic HIV-1 envelopes, IIIB gp120 was the most potent. In general, normal ligaments and tendons have low signal ...
Cudkowicz ME, Shefner JM, Simpson E, Grasso D, Yu H, Zhang H, Shui A, Schoenfeld D, Brown RH, Wieland S, Barber JR. Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis. Muscle Nerve. 2008 Jul; 38(1):837-44 ...
  • The carcinogen 4-nitroquinoline 1-oxide (4-NQO) was found to rapidly deplete non-protein thiols (NPSH) from Ehrlich ascites tumor cells and V79 Chinese hamster fibroblasts. (aacrjournals.org)
  • 4. Spencer, D. A reduced diphosphopyridine-specific nitrate reductase from germinating wheat. (qmul.ac.uk)
  • The effect of diverse metal oxides in graphene composites on the adsorption isotherm of gaseous benzene. (bioportfolio.com)
  • Graphene oxide wrapped copper-benzene-1,3,5-tricarboxylate metal organic framework as efficient absorbent for gaseous toluene under ambient conditions. (bioportfolio.com)
  • The ultrasonic-assisted hydrothermal and ethanol activation method was proposed to synthesize copper-benzene-1,3,5-tricarboxylate (Cu-BTC) metal organic framework and Cu-BTC/graphene oxide (GO) compos. (bioportfolio.com)
  • Greater thiol loss under oxic than under hypoxic conditions suggested oxidation by superoxide, peroxide, or hydroxyl radical formed in the course of 4-NQO reduction. (aacrjournals.org)
  • Glutathione, when present in culture medium during 4-NQO treatment, protected V79 cells from 4-NQO toxicity. (aacrjournals.org)
  • Both V79 and Ehrlich cells contained appreciable amounts of glutathione S -transferase (EC 2.5.1.18), which catalyzes the nucleophilic substitution of the nitro group of 4-NQO with thiols. (aacrjournals.org)
  • In addition, reaction of thiols with nitro radicals or with nitrosoquinoline 1-oxide was indicated by the inhibitory effect of glutathione on oxygen consumption in solutions of 4-NQO and sodium ascorbate. (aacrjournals.org)
  • Some of the major conceptual advances in chemical carcinogenesis made during the past several years have been (1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate carcinogens, (2) the characterization of interactions of the active metabolites of many carcinogens with a variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. (springer.com)
  • It is known that mutations in somatic cells play a key role in cancer initiation and carcinogenesis process [ 1 ]. (hindawi.com)
  • A hierarchical structured steel mesh decorated with metal organic framework/graphene oxide for high-efficient oil/water separation. (bioportfolio.com)
  • A hierarchical structured steel mesh decorated with metal organic framework (UiO-66-NH) nanoparticles/graphene oxide (GO) nanosheets was successfully prepared via a simple self-assemble method. (bioportfolio.com)
  • Two other HCAs, 3-amino-1,4-dimethyl-5 H -pyriod[4,3- b ]indole (Trp-P-1) and 2-amino-3,4,8-trimethylimidazo[4,5- f ]quinoxaline (DiMeQx), have shown tumor-promoting activity in hamsters ( 12 ). (aacrjournals.org)
  • Human lymphoblastoid cells (TK6, MCL-5) were treated for either 4 or 23 h with 8 known in vivo carcinogens, with doses up to 50% Relative Population Doubling (maximum 66.6 mM). (bvsalud.org)
  • Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39208&idtype=1″ active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39208&idtype=1&closed=1″ closed clinical trials using this agent. (healthmatics.info)
  • These drugs have an advantage over the synthetic drugs in terms of low or no toxicity at the effective dose [ 4 ]. (hindawi.com)
  • Among the modified nucleosides, an interesting discovery, published as my first research paper, was the fluorescent, methylated 1,N 2 -etheno-guanine-derivatized Yt base (wyosine nucleoside) in T. utilis tRNA phe [ 1 , 2 ] (Fig. 1 ), which is biosynthesized from 3-methylguanine. (biomedcentral.com)
  • The present study was performed as part of an attempt to authenticate the use of Inula racemosa root extract as traditional medicine in India by experimentally investigating their protective effects on 4-nitroquinoline-1-oxide (4-NQO) induced DNA damage and apoptosis in mice bone marrow cells. (hindawi.com)
  • 4-NQO (7.5 mg/kg bw) was injected intraperitoneally to the mice on the sixth day. (hindawi.com)
  • This was the first report that recorded the protective effects of I. racemosa on 4-NQO-induced DNA damage and apoptosis in mice bone marrow cells. (hindawi.com)
  • 9. A photoconductor in accordance with claim 8 wherein said alkyl and said alkoxy each contains from about 1 to about 12 carbon atoms, and said aryl contains from about 6 to about 36 carbon atoms. (patentsencyclopedia.com)
  • 12. A photoconductor in accordance with claim 11 wherein alkyl and alkoxy each contains from about 1 to about 12 carbon atoms, and aryl contains from about 6 to about 36 carbon atoms, and at least one is one. (patentsencyclopedia.com)
  • 0.1 to 0.3 μg/ml) relative to uninfected cells treated with 4‐HAQO alone. (utmb.edu)
  • No increase in the percentage of aberrant cells or the frequency of chromosome aberrations was observed in HCMV‐infected cells treated with 4‐nitroquinoline‐1oxide (4‐NQO) relative to similarly treated uninfected PBLs. (utmb.edu)
  • Optical and structural properties of the investigated matrix ZnO(1-x)SiO2(x) system were characterized by various techniques such as X-ray analysis and UV-VIS-NIR absorption. (statescale.ml)
  • Dexamethasone inhibition of TGF beta-induced cell growth and type II collagen mRNA expression through ERK-integrated AP-1 activity in cultured rat articular chondrocytes. (statescale.ml)
  • The NPSH thus appeared to play a significant role in 4-NQO detoxification. (aacrjournals.org)
  • Abbott , P. J., And Saffhill , R., 1977, DNA synthesis with methylated poly(dA-dT) template: Possible role of O 4 -methylthymine as a promutagenic base, Nucleic Acids Res . (springer.com)
  • Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (healthmatics.info)