(1/14) Dual effects of prolonged ACTH stimulation on 4-hydroxyaminoquinoline 1-oxide-induced adrenocortical lesions in rats.

The effects of a long-acting synthetic ACTH on 4-hydroxyaminoquinoline 1-oxide (4HAQO)-induced adrenocortical lesions were investigated in female rats. A total of 140 6-week-old rats were divided into 4 equal groups, given a single s.c. injection of 7 mg/kg 4HAQO or vehicle, followed by repeated sc administration of the synthetic ACTH or no further treatment. Subgroups of 10 rats in each group were sequentially sacrificed at weeks 20, 30, and 40. Adenomas and adenomatous nodules developed in the adrenal cortex of animals receiving 4HAQO and the chronic ACTH stimulation. Both lesions were located in the deeper zones of the adrenal cortex adjacent to the medulla and were composed of large-sized, clear-type cells. From week 20, middle zone, cortical cystic degeneration, which mimics the age-associated degenerative change named adrenal peliosis, was frequently observed in the adrenal glands of animals treated with 4HAQO alone. Its development was inhibited by ACTH. In the control animals, peliotic changes occurred at low incidence and only at the termination of experiment. These results indicate that long-term stimulation of ACTH promotes the development of adrenocortical tumors but suppresses the occurrence of adrenal peliosis in rats treated with 4HAQO.  (+info)

(2/14) Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide.

The inducibility of pancreatic islet cell tumors by administration of 4-hydroxyaminoquinoline 1-oxide (4HAQO) was investigated in male 6-week-old Sprague-Dawley rats. Rats were given 4HAQO intravenously at a weekly dose of 5 mg/kg 4 times (group 1) or a single dose of 10 mg/kg (group 2). Control rats received the vehicle alone (group 3). Fifty-six weeks after the first 4HAQO administration, all surviving animals were killed and the pancreas was examined histopathologically, immunohistochemically and ultrastructurally. The incidences and multiplicities of islet cell tumors in groups 1, 2, and 3 were 52.3% (p < 0.05 vs group 2, p < 0.01 vs group 3), 19.2% and 0%, and 0.70/animal (p < 0.05 vs group 2, p < 0.01 vs group 3), 0.23 and 0, respectively. Islet cell carcinomas were induced only in group 1, accounting for 6/44 (26%) tumors. Islet cell hyperplasias were found in 61.4% (p < 0.05 vs group 3), 42.3% and 10.0% of groups 1, 2, and 3, with multiplicities of 0.95 (p < 0.05 vs groups 2 and 3), 0.54 and 0.20, respectively. As compared with normal islets from control subjects, islet cell tumors showed an increase in the number of insulin positive cells associated with cytological features indicative of enhanced insulin synthesis and secretion, and a decrease in the number of glucagon positive cells without ultrastructural signs of modified secretory activity. Thus our results indicate that repeated intravenous administration of 4HAQO to rats is useful for the induction of islet cell tumors at high incidence.  (+info)

(3/14) Sequential alteration of apoptosis, p53 expression, and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide.

Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body weight and control rats received vehicle alone and were euthanized after 2-72 hours. Pancreata and livers were removed for histopathological examination, immunohistochemistry for p53 protein, PCNA and Ki-67, and TUNEL labeling and electron microscopic observation for detecting apoptosis. In the pancreas, p53 expression and apoptosis were significantly increased first at 4 and 6 hours, respectively, while no change was evident in the liver. The rates peaked at 24 hours, consistent with the peak for PCNA-labeling, while Ki-67-labeling rates peaked at 72 hours. Electron microscopically, apoptotic changes in pancreatic acinar cells were observed after 2 hours. No significant apoptosis, p53 expression or cell proliferation were noted in the pancreatic tissues of the control rats nor in liver cells regardless of 4HAQO treatment. Taken together with our previous data, the results suggest that apoptosis, p53 expression, and enhanced cell replication are closely related phenomena involved in the carcinogenesis of 4HAQO following DNA adduct formation.  (+info)

(4/14) The FLP protein contacts both major and minor grooves of its recognition target sequence.

The FLP protein of the 2 microns plasmid of Saccharomyces cerevisiae promotes conservative site-specific recombination between DNA sequences that contain the FLP recognition target (FRT). FLP binds to each of the three 13 base pair symmetry elements in the FRT site in a site-specific manner. We have probed both major and minor groove contacts of FLP using dimethyl sulphate, monoacetyl-4-hydroxyaminoquinoline 1-oxide and potassium permanganate and find that the protein displays extensive interactions with residues of both the major and minor grooves of 10 base pairs of each symmetry element. We find no evidence that the FRT site assumes a single-stranded conformation upon FLP binding.  (+info)

(5/14) Interaction of RecA protein with pBR322 DNA modified by N-hydroxy-2-acetylaminofluorene and 4-hydroxyaminoquinoline 1-oxide.

Interaction of RecA protein of Escherichia coli with pBR322 DNA modified by N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and 4-hydroxyaminoquinoline 1-oxide (4HAQO) was investigated. RecA protein bound more efficiently to modified DNA than to unmodified DNA as judged by filter-binding and gel electrophoresis assay. The binding of RecA protein with modified DNA resulted in the stimulation of ATPase activity and the activation for RecA protein to stimulate the repressor cleavage. These abilities of RecA protein were increased proportionally to the number of adducts in the plasmid DNA (0-5 adducts). Apurinic and alkylated DNA did not activate RecA protein. We suggest that modification of DNA by N-OH-AAF and 4HAQO provides binding sites for RecA protein and may act as an activation signal for SOS response.  (+info)

(6/14) 5-Chloro-7-iodo-8-hydroxyquinoline (clioquinol) inhibits the nerve growth factor-induced stimulation of RNA synthesis in neonatal rat superior cervical ganglion, in vitro--comparison with effects of methylmercuric chloride and 4-hydroxyaminoquinoline-N-oxide.

The inhibitory effects of 5-chloro-7-iodo-8-hydroxy-quinoline (clioquinol), methylmercuric chloride and 4-hydroxyaminoquinoline-N-oxide(4-HAQO) on DNA, RNA and protein syntheses in the neonatal rat superior cervical ganglion (SCG) were studied in relation to the action of mouse 2.5S nerve growth factor (NGF), using organ cultures. RNA and protein syntheses in SCG were stimulated approximately 3- and 2-fold, respectively, by NGF (1 microgram/ml), but the DNA synthesis was only slightly or not at all stimulated. Methylmercuric chloride and 4-HAQO dose-dependently inhibited DNA, RNA and protein syntheses, either in the presence or in the absence of NGF. On the other hand, clioquinol (up to 100 microM) slightly or not at all inhibited RNA synthesis in the absence of NGF; however, it did abolish the NGF-induced stimulation of RNA synthesis in the presence of NGF. The DNA and protein syntheses were dose-dependently inhibited by clioquinol, either in the presence or in the absence of NGF. We conclude from this study that the interaction between clioquinol and the functions of NGF raises the question of a possible toxicity of the drug on specific neurons.  (+info)

(7/14) In vivo studies on age dependency of DNA repair with age in mouse skin.

Since the capacity for DNA repair relative to other cellular processes is an important parameter relevant to mutagenesis, carcinogenesis, and also aging, its assessment should preferably be carried out in intact animals. For this reason we developed an autoradiographic technique for measuring DNA repair directly in vivo. By this method unscheduled DNA synthesis (UDS) can be detected quantitatively as silver grains over epithelial cells of mouse skin after treatment with chemical carcinogens or ultraviolet (UV) irradiation. Possible age-related change in UDS response was examined by this skin technique using 2- and 18-mo-old mice. Similar dose-dependent induction of UDS was observed in mice of both ages after treatment with 4-hydroxyaminoquinoline 1-oxide. The dose-response curves for young and aged animals after UV irradiation also showed similar increases to a plateau level at low doses, but their responses to high doses were very different. In aged mice the UDS level decreased markedly with increase in dose, whereas in young mice it remained at the same plateau level. This suggests that, in aged animals, high doses of UV irradiation cause deterioration of DNA repair systems, and that aged animals cannot repair extensive UV-induced DNA damage efficiently.  (+info)

(8/14) Adducts from in vivo action of the carcinogen 4-hydroxyaminoquinoline 1-oxide in rats and from in vitro reaction of 4-acetoxyaminoquinoline 1-oxide with DNA and polynucleotides.

In vivo 4-hydroxyamino[2-3H]quinoline 1-oxide-modified DNA and in vitro 4-acetoxyamino[2-3H]quinoline 1-oxide-modified DNA were enzymatically hydrolyzed, and the hydrolysates were analyzed by high-performance liquid chromatography. The two patterns were compared, and we showed that all of the high-performance liquid chromatography peaks which were recovered from in vivo-modified DNA were present in the hydrolysate of in vitro-modified DNA. Therefore, we used the in vitro 4-acetoxyamino[2-3H]quinoline 1-oxide-modified DNA to investigate the quinoline-purine adducts which are characteristics of the mode of action of the carcinogen 4-nitroquinoline 1-oxide. By comparison with the enzymatic hydrolysates of 4-acetoxyamino[2-3H]quinoline 1-oxide-modified covalent poly(deoxyadenylate-deoxythymidylate) X poly(deoxyadenylate-deoxythymidylate) and covalent poly(deoxyguanylate-deoxycytidylate) X poly(deoxyguanylate-deoxycytidylate) three nitroquinoline adducts were enumerated on the modified DNA. One of them was previously characterized as a C8-guanyl adduct. We proved that the two other are a guanine and an adenine adduct, respectively. A quinoline derivative was identified in the hydrolysates of the in vivo- and in vitro-modified DNAs as 4-aminoquinoline 1-oxide, the origin of which was postulated to be a degradation compound of one (or more) adduct(s). Moreover, the presence of two degradation compounds of the C8-guanyl adduct was shown in mild alkaline conditions. We suspected an imidazole ring-opened form.  (+info)

*  4-Nitroquinoline 1-oxide
... (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
*  List of MeSH codes (D02)
... polyvinylpyridine n-oxide MeSH D02.455.326.271.884.533.699 --- povidone MeSH D02.455.326.271.884.533.710 --- povidone-iodine ... ethylene oxide MeSH D02.355.291.411.900 --- trichloroepoxypropane MeSH D02.355.291.705 --- okadaic acid MeSH D02.355.291.852 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ...
*  List of MeSH codes (D03)
... polyvinylpyridine n-oxide MeSH D03.383.725.762 --- pyridinium compounds MeSH D03.383.725.762.232 --- cetylpyridinium MeSH ... 4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438.834.850 --- ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 --- epirizole MeSH D03.383.129.539.487 ...
*  Nitroquinoline-N-oxide reductase
... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O ⇌ {\displaystyle \rightleftharpoons } 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 ... hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO ... In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction 4-( ... On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi. 24: 423-432. Stanley JS, York JL, Benson AM (1992 ...
4-Hydroxyaminoquinoline-1-oxide 11211-S  4-Hydroxyaminoquinoline-1-oxide 11211-S
Testing Status of 4-Hydroxyaminoquinoline-1-oxide 11211-S. CASRN: 4637-56-3. Formula: C9-H8-N2-O2. Synonyms/Common Names. *N- ... 4-OH-Aminoquinoline-1-OX. Known Uses. Reasonably anticipated to be a human carcinogen based upon its use as a prototypical ... 2): 1-251.. *Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon ...
more infohttps://ntp.niehs.nih.gov/testing/status/agents/ts-11211-s.html
Haz-Map Category Details  Haz-Map Category Details
... oxide; 4-Quinolinamine, N-hydroxy-, 1-oxide; Quinoline, 4-(hydroxyamino)-, 1-oxide; [ChemIDplus] 4-Quinolinamine-N-hydroxy-1- ... Hydroxyamino)quinoline 1-oxide; 4-(Hydroxyamino)quinoline-1-oxide; 4-Hydroxyaminoquinoline N-oxide; 4HAQO; Hydroxylamine, N-(4- ... oxide; 4-Quinolinamine, N-hydroxy-, 1-oxide; Quinoline, 4-(hydroxyamino)-, 1-oxide; [ChemIDplus] 4-Quinolinamine-N-hydroxy-1- ... Hydroxyamino)quinoline 1-oxide; 4-(Hydroxyamino)quinoline-1-oxide; 4-Hydroxyaminoquinoline N-oxide; 4HAQO; Hydroxylamine, N-(4- ...
more infohttps://hazmap.nlm.nih.gov/category-details?id=11628&table=copytblagents
ChemIDplus - 16939-80-3 - WEFBFRBNXOXZGH-UHFFFAOYSA-N - Quinoline, 7-chloro-4-(hydroxyamino)-, 1-oxide, hydrochloride - Similar...  ChemIDplus - 16939-80-3 - WEFBFRBNXOXZGH-UHFFFAOYSA-N - Quinoline, 7-chloro-4-(hydroxyamino)-, 1-oxide, hydrochloride - Similar...
7-chloro-4-(hydroxyamino)-, 1-oxide, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other ... 1S/C9H7ClN2O2.ClH/c10-6-1-2-7-8(11-13)3-4-12(14)9(7)5-6;/h1-5,11,13H;1H. Download. ... Substance Name: Quinoline, 7-chloro-4-(hydroxyamino)-, 1-oxide, hydrochloride. RN: 16939-80-3. InChIKey: WEFBFRBNXOXZGH- ...
more infohttps://chem.nlm.nih.gov/chemidplus/rn/16939-80-3
Plus it  Plus it
Two other HCAs, 3-amino-1,4-dimethyl-5H-pyriod[4,3-b]indole (Trp-P-1) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline ( ... Multipotential carcinogenicity of the fried food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Jpn J Cancer Res 1985 ... Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its n-hydroxy ... The study population was 97% Caucasian (Table 1). The mean ages of the cases and controls were 65.4 and 66.0 years, ...
more infohttp://cebp.aacrjournals.org/content/14/9/2261
Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells | Cancer Research  Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells | Cancer Research
1 This investigation was supported in part by Grants CA 13747, CA 19283, and CA 15901 awarded by the National Cancer Institute ... Interactions of the Carcinogen 4-Nitroquinoline 1-oxide with the Non-Protein Thiols of Mammalian Cells. Marie E. Varnes and ... The carcinogen 4-nitroquinoline 1-oxide (4-NQO) was found to rapidly deplete non-protein thiols (NPSH) from Ehrlich ascites ... The NPSH thus appeared to play a significant role in 4-NQO detoxification. Glutathione, when present in culture medium during 4 ...
more infohttp://cancerres.aacrjournals.org/content/39/8/2960?ijkey=db2538f795c64a1f2b1e689d45c44dd0dafc8d65&keytype2=tf_ipsecsha
Table of Contents | Cancer Research  Table of Contents | Cancer Research
Oxidation of Sulfhydryl Compounds in Vitro by 4-Hydroxyaminoquinoline-1-oxide, a Carcinogenic Metabolite of 4-Nitroquinoline-1- ... oxide. Motoo Hozumi, Sunako Inuzuka and Takashi Sugimura. Cancer Res August 1 1967 27 (8 Part 1) 1378-1383; ...
more infohttp://cancerres.aacrjournals.org/content/27/8_Part_1
Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids | Springer for Research & Development  Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids | Springer for Research & Development
1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate... ... Myles, A., And Brown, G. B., 1969, Purine N-oxides. Xxx. Biochemical studies of the oncogen 3-hydroxyxanthine, J. BioL Chem. ... Martin, C. N., And Garner, R. C., 1977, Aflatoxin B1 oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes ... guanine-3-N-oxide and some related compounds, Cancer Res. 30: 184.PubMedGoogle Scholar ...
more infohttps://rd.springer.com/chapter/10.1007%2F978-1-4615-6598-7_10
4-Nitroquinoline 1-oxide - Wikipedia  4-Nitroquinoline 1-oxide - Wikipedia
4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518 . PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
more infohttps://en.wikipedia.org/wiki/4-Nitroquinoline_1-oxide
KAKEN - Research Projects | Experimental Study of Inhibition for Spontaneous Lung Metastases of Transplantable Rat Osteosarcoma...  KAKEN - Research Projects | Experimental Study of Inhibition for Spontaneous Lung Metastases of Transplantable Rat Osteosarcoma...
1. Angiogenesis is a crucial event not only for the establishment of secondary growths but also the allow the primary tumor to ... 3. Mutations of p53 in exon 7 were detected in J.H.2-OS,but not in J.H.1-OS,irrespective of the metastatic potentials. Direct ... We have maintained two transplantable rat osteosarcomas, J.H.1-OS is spontaneous osteosarcoma and J.H.2-OS is induced by 4-HAQO ... Publications] A.Kido: 'p53 mutation and absence of mdm2 amplification and Ki-ras mutation in 4-hydroxyamino quinoline 1-oxide ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671472/
Bimetallic Metal-Organic-Framework/Reduced Graphene Oxide Composite as Bifunctional Electrocatalyst for Rechargeable Zn-Air...  Bimetallic Metal-Organic-Framework/Reduced Graphene Oxide Composite as Bifunctional Electrocatalyst for Rechargeable Zn-Air...
Hierarchical zinc oxide/reduced graphene oxide composite: Preparation route, mechanism study and lithium ion storage. ... A novel and simple approach to preparing hierarchical zinc oxide/reduced graphene oxide (ZnO/[email protected]) composite is demonstrated ... Nitric Oxide. A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC ... Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2340788/Bimetallic-Metal-Organic-Framework-Reduced-Graphene-Oxide-Composite-as-Bifunctional-Electrocatalyst-for.html
Caffeine (IARC Summary & Evaluation, Volume 51, 1991)  Caffeine (IARC Summary & Evaluation, Volume 51, 1991)
1,3,7-Trimethylxanthine *Vivarin Last updated: 17 November 1997 See Also: Toxicological Abbreviations Caffeine (ICSC) ... Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 5. Summary of Data Reported and Evaluation. 5.1 Exposure data. Caffeine ... Caffeine did not influence the incidence of bladder tumours induced in rats by N-nitroso-N-butyl(4-hydroxybutyl)amine in three ... experiments or of pancreatic tumours induced in rats by 4-hydroxyaminoquinoline-1-oxide in another study. 5.3 Human ...
more infohttp://inchem.org/documents/iarc/vol51/04-caffeine.html
List of MeSH codes (D02) - Wikipedia  List of MeSH codes (D02) - Wikipedia
... polyvinylpyridine n-oxide MeSH D02.455.326.271.884.533.699 --- povidone MeSH D02.455.326.271.884.533.710 --- povidone-iodine ... ethylene oxide MeSH D02.355.291.411.900 --- trichloroepoxypropane MeSH D02.355.291.705 --- okadaic acid MeSH D02.355.291.852 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Silent Spring Institute  Silent Spring Institute
10b-oxide. 138857-19-9 anti-4,5-dihydroxy-6,6a-epoxy-4,5,6,6a-tetrahydrobenzo[j]fluoranthene ... n,n' -[ 6-( 5- nitro-2-furyl)-s-triazine- 2,4-diyl]bisacetamide ...
more infohttp://sciencereview.silentspring.org/mamm_browse.cfm
Additional pages  Product Categories   - Healthmatics | Page 324  Additional pages Product Categories - Healthmatics | Page 324
kyselina 4-aminobenzoová A member of the VITAMIN B COMPLEX. It used to be common in SUNSCREENING AGENTS until found to also be ... 4-butyrolakton One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma ... 4-aminopyridin One of the POTASSIUM CHANNEL BLOCKERS, with secondary effect on calcium currents, which is used mainly as a ... 4-hydroxyaminochinolin-1-oxid A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds ...
more infohttp://healthmatics.info/products-page/additional-pages/page/324/
Antimutagenic and Antiapoptotic Effects of Aqueous Root Extract of Inula racemosa Hook. f. on 4-NQO-Induced Genetic Damage in...  Antimutagenic and Antiapoptotic Effects of Aqueous Root Extract of Inula racemosa Hook. f. on 4-NQO-Induced Genetic Damage in...
4-NQO-induced total apoptotic cells were about 12% over the control which was significantly brought down to 3.5% by ... However, the 4-NQO-induced MnPCEs reduced by ARE were found to be dose dependent and consistently significant (. ). ... However, the 4-NQO-induced MnPCEs reduced by ARE were consistently significant (. ). PCE/NCE ratio also significantly decreased ... Group 1 was used as a control which was fed with distilled water orally. Group 2 was fed orally with 400 mg/kg bw of ARE for ...
more infohttps://www.hindawi.com/journals/isrn/2013/768359/
KAKEN - Researchers | IMAIDA Katsumi (90160043)  KAKEN - Researchers | IMAIDA Katsumi (90160043)
4ーhydroxyaminoquinolinel-oxide / 分子プロファイリング / peliosis adrenalis / 発ガンリスク評価 / basophilic acihar foci / ニトロソ化合物 / エストロゲン / 移植がん ... Book] 第2部社会問題となった疾患と病理学〈環境〉(4.内分泌撹乱化学物質(環境ホルモン)病理と臨床 臨時増刊号)(深山正久, 樋野興夫, 坂元亨宇, 中山淳, 羽場礼次(編集)2009. *. Author(s). 今井田克己 ... Journal Article] Lack of promoting effects from physical pulmonary collapse in a female A/J mouse
more infohttps://nrid.nii.ac.jp/en/nrid/1000090160043/
Pubblicazioni  Pubblicazioni
DNA Repair, 4: 546-555, 2005.. 2003. *CARUSO M., CAVALDESI M., GENTILE M., STHANDIER O., AMATI P. AND GARCIA M-I. Role of ... 1-12, 2011. *MAIDA I., FONDI M., PAPALEO M.C., PERRIN E., FANI R.- Appl. Informatics j., 5:62-76, 2011 The gene flow between ... PLOS Genetics 11:1-14. *GIAMPIETRO C., DEFLORIAN G., GALLO S., DI MATTEO A., PRADELLA D., BONOMI S., BELLONI S., NYQUIST D., ... Cancer, 1: 287-298, 1999.. *INGA A., CHEN F-X., MONTI P., APRILE A., CAMPONENOSI P., MENICHINI P., OTTAGGIO L., VIAGGI S., ...
more infohttp://www.fondazioneadrianobuzzatitraverso.it/site/contributi-alla-ricerca/pubblicazioni/
What causes human cancer? Approaches from the chemistry of DNA damage | Genes and Environment | Full Text  What causes human cancer? Approaches from the chemistry of DNA damage | Genes and Environment | Full Text
1) Oxidative DNA damage: 8-Hydroxydeoxyguanosine (8-OHdG, 8-oxodG) was discovered during a structural study of DNA ... 2013;4:213-20.View ArticlePubMedGoogle Scholar. *. Stirzaker C, Song JZ, Davidson B, Clark SJ. Transcriptional gene silencing ... 2011;4:177-84.View ArticleGoogle Scholar. *. Sawa T, Akaike T, Kida K, Fukushima Y, Takagi K, Maeda H. Lipid peroxyl radicals ... 1992;114:9692-4.View ArticleGoogle Scholar. *. Nunez ME, Hall DB, Barton JK. Long-range oxidative damage to DNA: effects of ...
more infohttps://genesenvironment.biomedcentral.com/articles/10.1186/s41021-016-0046-8
EC 1.7 and EC 1.8  EC 1.7 and EC 1.8
... hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. Other name(s): 4-nitroquinoline ... Accepted name: nitric oxide reductase (cytochrome c). Reaction: nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ... EC 1.7.2.3 trimethylamine-N-oxide reductase (cytochrome c). EC 1.7.2.4 nitrous-oxide reductase. EC 1.7.2.5 nitric oxide ... Accepted name: nitric oxide reductase (menaquinol). Reaction: 2 nitric oxide + menaquinol = nitrous oxide + menaquinone + H2O. ...
more infohttps://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC1/07p.html
Faculty Collaboration Database - Mesh term Cyclic N-Oxides  Faculty Collaboration Database - Mesh term Cyclic N-Oxides
Mesh term Cyclic N-Oxides. Browse to parent terms:. Heterocyclic Oxides. Description. Heterocyclic compounds in which an oxygen ... 4-Nitroquinoline-1-oxide. Triacetoneamine-N-Oxyl. Search for this term in our Faculty Database. View this term at the NCBI ...
more infohttps://fcd.mcw.edu/?module=search&func=showTerm&id=68003497
  • We have maintained two transplantable rat osteosarcomas, J.H.1-OS is spontaneous osteosarcoma and J.H.2-OS is induced by 4-HAQO,in Fischer 344/Nslc rats and successfully established highly metastatic tumors (S-SLM and C-SLM) by selectively transplanting lung metastatic nodules (in vivo selection). (nii.ac.jp)
  • Caffeine did not influence the incidence of bladder tumours induced in rats by N -nitroso- N -butyl(4-hydroxybutyl)amine in three experiments or of pancreatic tumours induced in rats by 4-hydroxyaminoquinoline-1-oxide in another study. (inchem.org)
  • The effect of diverse metal oxides in graphene composites on the adsorption isotherm of gaseous benzene. (bioportfolio.com)
  • Graphene oxide wrapped copper-benzene-1,3,5-tricarboxylate metal organic framework as efficient absorbent for gaseous toluene under ambient conditions. (bioportfolio.com)
  • The ultrasonic-assisted hydrothermal and ethanol activation method was proposed to synthesize copper-benzene-1,3,5-tricarboxylate (Cu-BTC) metal organic framework and Cu-BTC/graphene oxide (GO) compos. (bioportfolio.com)
  • A hierarchical structured steel mesh decorated with metal organic framework/graphene oxide for high-efficient oil/water separation. (bioportfolio.com)
  • A hierarchical structured steel mesh decorated with metal organic framework (UiO-66-NH) nanoparticles/graphene oxide (GO) nanosheets was successfully prepared via a simple self-assemble method. (bioportfolio.com)
  • Two other HCAs, 3-amino-1,4-dimethyl-5 H -pyriod[4,3- b ]indole (Trp-P-1) and 2-amino-3,4,8-trimethylimidazo[4,5- f ]quinoxaline (DiMeQx), have shown tumor-promoting activity in hamsters ( 12 ). (aacrjournals.org)
  • Glutathione, when present in culture medium during 4-NQO treatment, protected V79 cells from 4-NQO toxicity. (aacrjournals.org)
  • These drugs have an advantage over the synthetic drugs in terms of low or no toxicity at the effective dose [ 4 ]. (hindawi.com)
  • The effects of NPSH on 4-NQO metabolism were studied by measuring 4-hydroxyaminoquinoline 1-oxide formation, CN −1 -insensitive oxygen consumption, and reduction of ferricytochromes c + c 1 in normal cells and in cells pretreated with the thiol reagent N -ethylmaleimide. (aacrjournals.org)
  • In addition, reaction of thiols with nitro radicals or with nitrosoquinoline 1-oxide was indicated by the inhibitory effect of glutathione on oxygen consumption in solutions of 4-NQO and sodium ascorbate. (aacrjournals.org)
  • Hierarchical zinc oxide/reduced graphene oxide composite: Preparation route, mechanism study and lithium ion storage. (bioportfolio.com)
  • The present study was performed as part of an attempt to authenticate the use of Inula racemosa root extract as traditional medicine in India by experimentally investigating their protective effects on 4-nitroquinoline-1-oxide (4-NQO) induced DNA damage and apoptosis in mice bone marrow cells. (hindawi.com)
  • 9. A photoconductor in accordance with claim 8 wherein said alkyl and said alkoxy each contains from about 1 to about 12 carbon atoms, and said aryl contains from about 6 to about 36 carbon atoms. (patentsencyclopedia.com)
  • 12. A photoconductor in accordance with claim 11 wherein alkyl and alkoxy each contains from about 1 to about 12 carbon atoms, and aryl contains from about 6 to about 36 carbon atoms, and at least one is one. (patentsencyclopedia.com)
  • This was the first report that recorded the protective effects of I. racemosa on 4-NQO-induced DNA damage and apoptosis in mice bone marrow cells. (hindawi.com)
  • The NPSH thus appeared to play a significant role in 4-NQO detoxification. (aacrjournals.org)
  • Abbott , P. J., And Saffhill , R., 1977, DNA synthesis with methylated poly(dA-dT) template: Possible role of O 4 -methylthymine as a promutagenic base, Nucleic Acids Res . (springer.com)
  • It is known that mutations in somatic cells play a key role in cancer initiation and carcinogenesis process [ 1 ]. (hindawi.com)
  • Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (healthmatics.info)
  • Among the modified nucleosides, an interesting discovery, published as my first research paper, was the fluorescent, methylated 1,N 2 -etheno-guanine-derivatized Yt base (wyosine nucleoside) in T. utilis tRNA phe [ 1 , 2 ] (Fig. 1 ), which is biosynthesized from 3-methylguanine. (biomedcentral.com)
  • Both V79 and Ehrlich cells contained appreciable amounts of glutathione S -transferase (EC 2.5.1.18), which catalyzes the nucleophilic substitution of the nitro group of 4-NQO with thiols. (aacrjournals.org)
  • there are no screening tests for early detection and about 90% of cases present with late stage disease ( 1 , 2 ). (aacrjournals.org)
  • 6. A photoconductor in accordance with claim 1 wherein said aminoquinoline is present in an amount of from about 3 to about 15 weight percent. (patentsencyclopedia.com)
  • Removal of thiols before treatment with 4-NQO resulted in increased production of 4-hydroxyaminoquinoline 1-oxide and increased production of nitro radicals. (aacrjournals.org)
  • The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. (healthmatics.info)