AnatomyOrganismsChemicals and DrugsPhenomena and Processes
4-ButyrolactoneButyrophenonesStreptomycesMaturation-Promoting FactorCyclin-Dependent KinasesMeiosisEnzyme InhibitorsOocytes
4-Butyrolactone
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
Butyrophenones
Compounds containing phenyl-1-butanone.
Streptomyces
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
Maturation-Promoting Factor
Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Cyclin-Dependent Kinases
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
Meiosis
A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Oocytes
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).

Contact dermatitis in Alstroemeria workers. (1/836)

Hand dermatitis is common in workers in the horticultural industry. This study determined the prevalence of hand dermatitis in workers of Alstroemeria cultivation, investigated how many workers had been sensitized by tulipalin A (the allergen in Alstroemeria) and took stock of a wide range of determinants of hand dermatitis. The 12-month period prevalence of major hand dermatitis amounted to 29.5% whereas 7.4% had minor dermatitis. Of these workers, 52.1% were sensitized for tulipalin A. Several personal and work-related determinants played a role in the multifactorial aetiology of hand dermatitis. Factors which showed a significant relationship with major hand dermatitis were: female sex, atopic dermatitis, chapped hands and the frequency of washing hands. It may be concluded that the Alstroemeria workers are a population at risk of developing contact dermatitis and it might be useful to carry out an educational campaign to lower the high prevalence.  (+info)

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2. (2/836)

1. Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase A2 (PLA2), showing selectivity for secretory PLA2 (sPLA2) versus cytosolic PLA2 (cPLA2), and its potency on the human synovial enzyme (group II) was similar to that of manoalide. 2. This activity was confirmed in vivo in the 8 h zymosan-injected rat air pouch, on the secretory enzyme accumulating in the pouch exudate. Cacospongionolide B, that is bioavailable when is given orally, reduced the elevated levels of sPLA2 present in paw homogenates of rats with adjuvant arthritis. 3. This marine metabolite showed topical anti-inflammatory activity on the mouse ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA) and decreased carrageenin paw oedema in mice after oral administration of 5, 10 or 20 mg kg(-1). 4. In the mouse air pouch injected with zymosan, cacospongionolide B administered into the pouch, induced a dose-dependent reduction in the levels of eicosanoids and tumour necrosis factor alpha (TNFalpha) in the exudates 4 h after the stimulus. It also had a weak effect on cell migration. 5. The inflammatory response of adjuvant arthritis was reduced by cacospongionolide B, which did not significantly affect eicosanoid levels in serum, paw or stomach homogenates and did not induce toxic effects. 6 Cacospongionolide B is a new inhibitor of sPLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation. This marine metabolite was active after oral administration and able to modify TNFalpha levels, and may offer an interesting approach in the search for new anti-inflammatory agents.  (+info)

Human metabolism of mammalian lignan precursors in raw and processed flaxseed. (3/836)

BACKGROUND: The mammalian lignans enterolactone and enterodiol are produced in the colon by the action of bacteria on the plant precursor secoisolariciresinol diglycoside, which is found in high concentrations in flaxseed. OBJECTIVE: Two experiments were conducted to determine 1) whether there is a dose response in urinary lignan excretion with increasing flaxseed intake, 2) whether flaxseed processing affects lignan excretion, 3) peak plasma lignan concentrations, and 4) plasma lignan concentrations after chronic supplementation. DESIGN: Nine healthy young women supplemented their diets with 5, 15, or 25 g raw or 25 g processed (muffin or bread) flaxseed for 7 d during the follicular phase of their menstrual cycles. Twenty-four-hour urine samples were collected at baseline and on the final day of supplementation. As an adjunct to the 25-g-flaxseed arm, subjects consumed the supplement for an additional day and blood and urine samples were collected at specific intervals. All blood and urine samples were analyzed for enterolactone and enterodiol by gas chromatography-mass spectroscopy. RESULTS: A dose-dependent urinary lignan response to raw flaxseed was observed (r = 0.72, P < 0.001). The processing of flaxseed as a muffin or bread did not affect the quantity of lignan excretion. Plasma lignan concentrations were greater (P < or = 0.05) than baseline by 9 h after flaxseed ingestion (29.35+/-3.69 and 51.75+/-7.49 nmol/L, respectively). The total plasma area under the curve was higher on the eighth than on the first day (1840.15+/-343.02 and 1027.15+/-95.71 nmol x h/L, respectively). CONCLUSION: Mammalian lignan production from flaxseed precursors is dependent on time and dose but not on processing.  (+info)

Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. (4/836)

Acylated homoserine lactone (AHL)-mediated gene expression controls phenotypes involved in colonization, often specifically of higher organisms, in both marine and terrestrial environments. The marine red alga Delisea pulchra produces halogenated furanones which resemble AHLs structurally and show inhibitory activity at ecologically realistic concentrations in AHL bioassays. Evidence is presented that halogenated furanones displace tritiated OHHL [N-3-(oxohexanoyl)-L-homoserine lactone] from Escherichia coli cells overproducing LuxR with potencies corresponding to their respective inhibitory activities in an AHL-regulated bioluminescence assay, indicating that this is the mechanism by which furanones inhibit AHL-dependent phenotypes. Alternative mechanisms for this phenomenon are also addressed. General metabolic disruption was assessed with two-dimensional PAGE, revealing limited non-AHL-related effects. A direct chemical interaction between the algal compounds and AHLs, as monitored by 1H NMR spectroscopy, was shown not to occur in vitro. These results support the contention that furanones, at the concentrations produced by the alga, can control bacterial colonization of surfaces by specifically interfering with AHL-mediated gene expression at the level of the LuxR protein.  (+info)

Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. (5/836)

Products containing gamma-butyrolactone (GBL) are marketed for many claimed purposes, including to induce sleep, release growth hormone, enhance sexual activity and athletic performance, relieve depression, and prolong life. GBL is converted by the body into gamma-hydroxybutyrate (GHB), a drug banned outside of clinical trials approved by the Food and Drug Administration (FDA). Recognized manifestations of GHB toxicity include bradycardia, hypothermia, central nervous system depression, and uncontrolled movements. This report describes seven cases of GBL toxicity involving the product "Revivarant," which is labeled as containing 1.82 g of GBL per fluid ounce, reported from two hospital emergency departments (EDs) in Minnesota during October-December 1998 and summarizes an additional 34 cases of GBL toxicity reported to poison centers in New Mexico and Texas during October 1998-January 1999.  (+info)

Production of poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) and poly(4-hydroxybutyric acid) without subsequent degradation by Hydrogenophaga pseudoflava. (6/836)

A Hydrogenophaga pseudoflava strain was able to synthesize poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) [P(3HB-co-4HB)] having a high level of 4-hydroxybutyric acid monomer unit (4HB) from gamma-butyrolactone. In a two-step process in which the first step involved production of cells containing a minimum amount of poly(3-hydroxybutyric acid) [P(3HB)] and the second step involved polyester accumulation from the lactone, approximately 5 to 10 mol% of the 3-hydroxybutyric acid (3HB) derived from the first-step culture was unavoidably reincorporated into the polymer in the second cultivation step. Reincorporation of the 3HB units produced from degradation of the first-step residual P(3HB) was confirmed by high-resolution 13C nuclear magnetic resonance spectroscopy. In order to synthesize 3HB-free poly(4-hydroxybutyric acid) [P(4HB)] homopolymer, a three-stage cultivation technique was developed by adding a nitrogen addition step, which completely removed the residual P(3HB). The resulting polymer was free of 3HB. However, when the strain was grown on gamma-butyrolactone as the sole carbon source in a synthesis medium, a copolyester of P(3HB-co-4HB) containing 45 mol% 3HB was produced. One-step cultivation on gamma-butyrolactone required a rather long induction time (3 to 4 days). On the basis of the results of an enzymatic study performed with crude extracts, we suggest that the inability of cells to produce 3HB in the multistep culture was due to a low level of 4-hydroxybutyric acid (4HBA) dehydrogenase activity, which resulted in a low level of acetyl coenzyme A. Thus, 3HB formation from gamma-butyrolactone is driven by a high level of 4HBA dehydrogenase activity induced by long exposure to gamma-butyrolactone, as is the case for a one-step culture. In addition, intracellular degradation kinetics studies showed that P(3HB) in cells was completely degraded within 30 h of cultivation after being transferred to a carbon-free mineral medium containing additional ammonium sulfate, while P(3HB-co-4HB) containing 5 mol% 3HB and 95 mol% 4HB was totally inert in interactions with the intracellular depolymerases. Intracellular inertness could be a useful factor for efficient synthesis of the P(4HB) homopolymer and of 4HB-rich P(3HB-co-4HB) by the strain used in this study.  (+info)

Promotion of antibiotic production by high ethanol, high NaCl concentration, or heat shock in Pseudomonas fluorescens S272. (7/836)

A stress imposed by a continuous feed of high ethanol, high NaCl concentration, or a high temperature shock increased antibiotic production by several times in Pseudomonas fluorescens S272. A tentative bioassay showed that the stress caused about 40-fold elevation in the autoinducer activity. Addition of synthetic autoinducers, N-(3-oxododecanoyl)-L-homoserine lactone or N-(3-oxohexanoyl)-L-homoserine lactone at a concentration of more than 100 micrograms/l to a non-stressed culture also increased the antibiotic production by several times. These results suggested that the antibiotic production in P. fluorescens S272 was regulated by N-acyl-homoserine lactone and the promotive effect by stress occurred through any function that increased the autoinducer production.  (+info)

Acyl homoserine-lactone quorum-sensing signal generation. (8/836)

Acyl homoserine lactones (acyl-HSLs) are important intercellular signaling molecules used by many bacteria to monitor their population density in quorum-sensing control of gene expression. These signals are synthesized by members of the LuxI family of proteins. To understand the mechanism of acyl-HSL synthesis we have purified the Pseudomonas aeruginosa RhlI protein and analyzed the kinetics of acyl-HSL synthesis by this enzyme. Purified RhlI catalyzes the synthesis of acyl-HSLs from acyl-acyl carrier proteins and S-adenosylmethionine. An analysis of the patterns of product inhibition indicated that RhlI catalyzes signal synthesis by a sequential, ordered reaction mechanism in which S-adenosylmethionine binds to RhlI as the initial step in the enzymatic mechanism. Because pathogenic bacteria such as P. aeruginosa use acyl-HSL signals to regulate virulence genes, an understanding of the mechanism of signal synthesis and identification of inhibitors of signal synthesis has implications for development of quorum sensing-targeted antivirulence molecules.  (+info)

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Difference between revisions of IGEM:IMPERIAL/2006/Bibliography & Papers - OpenWetWareDifference between revisions of IGEM:IMPERIAL/2006/Bibliography & Papers - OpenWetWare
Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones (Cynthia H. Collins, Frances H. Arnold and Jared R. Leadbetter) Molecular Microbiology 2005 Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes (Yi-Han Lin, Jin-Ling Xu, Jiangyong Hu, Lian-Hui Wang, Say Leong, Jared Renton Leadbetter and Lian-Hui Zhang) Molecular Microbiology 2003 Quorum Sensing and Quorum-quenching enzymes (Yi-Hu Dong and Lian-Hui Zhang) Journal of Microbiology 2005 AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria (Park, et. al) Microbiology 2003 AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora PNAS 2000 The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase (Kim et al.) PNAS 2005 Communications blackout? Do ...
https://openwetware.org/wiki/?title=IGEM:IMPERIAL/2006/Bibliography_%252526_Papers&diff=54806&oldid=52201
γ-butyrolactone - Registration Dossier - ECHAγ-butyrolactone - Registration Dossier - ECHA
According to the National Toxicology Program (NTP, 1996), γ-Butyrolactone (GBL) is rapidly metabolized to gamma-hydroxybutyric acid and eliminated primarily as respiratory carbon dioxide and urinary metabolites. GHB is converted eventually to succinic acid, which enters the Krebs cycle, eventually being eliminated mainly as carbon dioxide. GBL shares common segments of its metabolism and toxicokinetic pathway with 1,4 -Butanediol as well as other compounds that can be metabolized to gamma-hydroxy butyric acid. Approximately 10% of a dose applied to the skin of rats, is absorbed (NTP, 1992). A mean permeability constant of 0.0001 cm/hr (1.1 g/m2/hr) has been estimated (Ursin, 1995). ...
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γ-butyrolactone - Registration Dossier - ECHAγ-butyrolactone - Registration Dossier - ECHA
Acute oral toxicity Based on the results of acute oral toxicity testing (LD50 = 1582 mg/kg), gamma-butyrolactone is classified as Xn; R22 (Harmful if swallowed) under the EU DSD classification criteria (EU Directive 67/548/EEC). It is assigned an Acute Toxicity Category 4 rating (Harmful if swallowed) under the EU CLP classification criteria (EU Regulation 1272/2008). Acute inhalation toxicity Based on the presence of CNS effects, including drowsiness or dizziness in animal studies, gamma-butyrolactone is classified as R67 (Vapours may cause drowsiness and dizziness) under the EU DSD classification criteria (EU Directive 67/548/EEC). Gamma-butyrolactone would be rated STOT Single Exposure 3, based on CNS effects including drowsiness and or dizziness according to the EU CLP classification criteria (EU Regulation 1272/2008). Acute dermal toxicity Gamma-butyrolactone exhibits a low level of acute toxicity by the oral and inhalation routes of exposure. Furthermore, significant dermal absorption is ...
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EC 3.5.1.97EC 3.5.1.97
Accepted name: acyl-homoserine-lactone acylase. Reaction: an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate. Other name(s): acyl-homoserine lactone acylase; AHL-acylase; AiiD; N-acyl-homoserine lactone acylase; PA2385 protein; quorum-quenching AHL acylase; quorum-quenching enzyme; PvdQ; QuiP. Systematic name: N-acyl-L-homoserine-lactone amidohydrolase. Comments: Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This ...
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N-acyl-L-homoserine lactones are inter-kingdom signalling molecules controlling quorum sensing in the Gram-negative bacteria...
TY - JOUR. T1 - N-acyl-L-homoserine lactones are inter-kingdom signalling molecules controlling quorum sensing in the Gram-negative bacteria and priming plants increasing stress adaptation. AU - Moshynets, O.. AU - Babenko, L.. AU - Karakhim, S.. AU - Kharkhota, M.. AU - Kosakivska, I.. AU - Rogalsky, S.. AU - Shcherbatiuk, M.. AU - Suslova, O.. AU - Spiers, A.. PY - 2017/9. Y1 - 2017/9. U2 - 10.1111/febs.14174. DO - 10.1111/febs.14174. M3 - Meeting Abstract. VL - 284. SP - 358. EP - 358. JO - FEBS Journal. JF - FEBS Journal. SN - 1742-464X. IS - S1. T2 - 42nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back. Y2 - 10 September 2017 through 14 September 2017. ER - ...
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Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. | The Hughson LabSalmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. | The Hughson Lab
Miller, S.T., et al. Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell 15, 5, 677-87 (2004).
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Acidity-Directed Synthesis of Substituted γ-Butyrolactones from Aliphatic AldehydesAcidity-Directed Synthesis of Substituted γ-Butyrolactones from Aliphatic Aldehydes
see article for more reactions. Abstract. Depending on the strength of a Lewis or Br nsted acid catalyst, borate intermediates resulting from the crotylboration of aliphatic aldehydes with ester-containing crotylboronates form either γ-substituted-α-alkylidene-γ-butyrolactones via oxonia cope rearrangement-lactonization or β,γ-disubstituted-α-methylene-γ-butyrolactones via lactonization.. ...
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Dr. Tsaffrir Zor | The George S. Wise Faculty of Life SciencesDr. Tsaffrir Zor | The George S. Wise Faculty of Life Sciences
For a full list of publications. Selected recent publications. Yifat Glucksam-Galnoy, Roy Sananes, Nava Silberstein, Pnina Krief, Vladimir V. Kravchenko, Michael M. Meijler and Tsaffrir Zor, The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-L-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages, Journal of Immunology, 2013, 191, 337-344. (pdf). Dorit Avni, Yifat Glucksam and Tsaffrir Zor , The Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in mouse macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism, Biochemical Pharmacology, 2012, 83, 106-114. (pdf). Meir Goldsmith, Ala Daka, Nadia F. Lamour, Roi Mashiach, Yifat Glucksam, Charles E. Chalfant, Michael M. Meijler and Tsaffrir Zor, A ceramide analog inhibits cPLA2 activity and consequent PGE2 formation in LPS-stimulated macrophages, Immunology Letters, 2011, 135, 136-143. ( pdf ). Dorit Avni , Orna Ernst , Amir ...
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Butyrolactone III - Aspergillus and AspergillosisButyrolactone III - Aspergillus and Aspergillosis
ID 2: 235. Toxin: n. Systematic name: 2-Furancarboxylic acid, 2-[[3-[(3,3-dimethyloxiranyl)methyl]-4-hydroxyphenyl]methyl]-2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-. Molecular formulae: C24H24O8. Molecular weight: 440.44. Chemical abstract number: 87414-45-7. Literature reference:. ...
https://www.aspergillus.org.uk/secondary_metabolite/butyrolactone-iii/?wpv_view_count=62386-TCPID48201&wpv_paged=10
Butyrolactone III - Aspergillus and AspergillosisButyrolactone III - Aspergillus and Aspergillosis
ID 2: 235. Toxin: n. Systematic name: 2-Furancarboxylic acid, 2-[[3-[(3,3-dimethyloxiranyl)methyl]-4-hydroxyphenyl]methyl]-2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-. Molecular formulae: C24H24O8. Molecular weight: 440.44. Chemical abstract number: 87414-45-7. Literature reference:. ...
https://www.aspergillus.org.uk/secondary_metabolite/butyrolactone-iii/?wpv_view_count=62386-TCPID48201&wpv_paged=5
Gamma Butyrolactone Aroma & Flavour Chemical CAS 96-48-0 - Augustus Oils Ltd
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Reaction products of γ-butyrolactone,... - Registration Dossier - ECHAReaction products of γ-butyrolactone,... - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/23036/4/12
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
Many Gram-negative bacteria employ N-acylhomoserine lactones (AHLs) as quorum-sensing (QS) signal molecules to regulate virulence expression in a density-dependent manner. Quorum quenching (QQ) via enzymatic inactivation of AHLs is a promising strategy to reduce bacterial infections and drug resistance. Herein, a thermostable AHL lactonase (AidB), which could degrade different AHLs, with or without a substitution of carbonyl or hydroxyl at the C-3 position, was identified from the soil bacterium Bosea sp. strain F3-2. Ultrahigh-performance liquid chromatography analysis demonstrated that AidB is an AHL lactonase that hydrolyzes the ester bond of the homoserine lactone (HSL) ring. AidB was thermostable in the range 30 to 80°C and showed maximum activity after preincubation at 60°C for 30 min. The optimum temperature of AidB was 60°C, and the enzyme could be stably stored in double-distilled water (ddH2O) at 4°C or room temperature. AidB homologs were found only in Rhizobiales and ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:%22Lu,%20Can%22
Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by...Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by...
Quorum sensing (QS) denotes a density-dependent mode of inter-bacterial communication based on signal transmitter molecules. Active QS is present during chronic infections with the opportunistic pathogen Pseudomonas aeruginosa in immunocompromised patients. The authors have previously demonstrated a …
https://pubmed.ncbi.nlm.nih.gov/17464047/?dopt=Abstract
HBHL Definition: Hydroxybutanoyl Homoserine Lactone
definition of HBHL, what does HBHL mean?, meaning of HBHL, Hydroxybutanoyl Homoserine Lactone, HBHL stands for Hydroxybutanoyl Homoserine Lactone
http://www.abbreviationfinder.org/acronyms/hbhl_hydroxybutanoyl-homoserine-lactone.html
KEGG PATHWAY: Quorum sensing
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation ...
http://www.genome.jp/kegg-bin/show_pathway?map=ko02024&show_description=show
Team:BIOTEC Dresden/Modeling - 2010.igem.orgTeam:BIOTEC Dresden/Modeling - 2010.igem.org
In the extracellular environment the enzyme LuxI is present in form of the fusion construct, proteinA-LuxI. The conversion of S-adenosyl methionine (SAM) to acylated homoserine lactone (AHL) catalyzed by LuxI follows enzyme kinetics by Michaelis-Menten:. v = Vmax x SAMex/ (Km + SAMex) Next, AHL has to be transported across the membrane of the cell via diffusion. The inside concentration is therefore determined by the diffusion rate across the membrane (kdif), the initial concentration (AHLex) as well as the decay constant of AHL inside the cell (kAHL). d[AHL] dt= kdiff(AHLex- AHLin) -(kdec * AHLin) Furthermore AHL as well as constitutively expressed LuxR form a complex which can bind to the luxR promoter. The amount of AHL-LuxR complex binding the luxR promoter is dependent on the concentration of AHL, the concentration of LuxR and its degradation (kLuxR) the binding and dissociation constant of AHL and LuxR (kdis=. [LuxR-AHL]=kdis x [AHL] x [LuxR] A signal can be detected using different ...
https://2010.igem.org/Team:BIOTEC_Dresden/Modeling
In silico analyses of conservational, functional and phylogenetic distribution of the LuxI and LuxR homologs in Gram-positive...In silico analyses of conservational, functional and phylogenetic distribution of the LuxI and LuxR homologs in Gram-positive...
LuxI and LuxR are key factors that drive quorum sensing (QS) in bacteria through secretion and perception of the signaling molecules e.g. N-Acyl homoserine lactones (AHLs). The role of these proteins is well established in Gram-negative bacteria for intercellular communication but remain under-explored in Gram-positive bacteria where QS peptides are majorly responsible for cell-to-cell communication. Therefore, in the present study, we explored conservation, potential function, topological arrangements and evolutionarily aspects of these proteins in Gram-positive bacteria. Putative LuxI/LuxR containing proteins were retrieved using the domain-based strategy from InterPro v62.0 meta-database. Conservational analyses via multiple sequence alignment and domain showed that these are well conserved in Gram-positive bacteria and possess relatedness with Gram-negative bacteria. Further, Gene ontology and ligand-based functional annotation explain their active involvement in signal transduction ...
http://crdd.osdd.net/open/2065/
Gamma-butyrolactone GBL BDO 96 48 0 | Wuhan Adar New Material Co., Ltd - 20200722164407Gamma-butyrolactone GBL BDO 96 48 0 | Wuhan Adar New Material Co., Ltd - 20200722164407
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http://www.acevn.com/product_detail.php?item=20200722164407
Universitätsklinikum Heidelberg: PublikationenUniversitätsklinikum Heidelberg: Publikationen
Maurer S, Wabnitz GH, Kahle NA, Stegmaier S, Prior B, Giese T, Gaida MM, Samstag Y, Hänsch GM (2015). Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone. Front Immunol. 6 (369). PubMed DOI Wabnitz GH, Nessmann A, Kirchgessner H, Samstag Y (2015). InFlow microscopy of human leukocytes: a tool for quantitative analysis of actin rearrangements in the immune synapse. J Immunol Methods. 423:29-39. PubMed DOI. Schröder-Braunstein J, Gras J, Brors B, Schwarz S, Szikszai T, Lasitschka F, Wabnitz G, Heidtmann A, Lee YS, Schiessling S, Leowardi C, Al-Saeedi M, Ulrich A, Engelke A, Winter J, Samstag Y, Giese T, Meuer S (2014). Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model. PLoS One. 9(5):e97780. PubMed DOI. Riplinger SM, Wabnitz GH, Kirchgessner H, Jahraus B, Lasitschka F, Schulte B, van der Pluijm G, van der ...
https://www.klinikum.uni-heidelberg.de/immunologie/forschung/sektion-molekulare-immunologie/publikationen
Gene Controls Production of Protein That Blocks HIV From Entering Cells; People With Extra Copies Protected, Study Says -...Gene Controls Production of Protein That Blocks HIV From Entering Cells; People With Extra Copies Protected, Study Says -...
Individuals who have extra copies of a gene that produces a specific protein are less likely to contract HIV or develop AIDS than people from the same ...
http://www.thebody.com/content/art9046.html
Chemsex linked with increased diagnoses of HIV and other sexually transmitted infections | EurekAlert! Science NewsChemsex linked with increased diagnoses of HIV and other sexually transmitted infections | EurekAlert! Science News
Chemsex -- the use of crystallized methamphetamine, mephedrone, γ-hydroxybutyrate or γ-butyrolactone and to a lesser extent cocaine and ketamine to facilitate sex -- has emerged as a new phenomenon in the UK and across Europe among gay, bisexual and other men who have sex with men (GBMSM).
https://www.eurekalert.org/pub_releases/2018-05/w-clw052118.php
We also showed here that the expression of Necl-4 was regulated in a cell density-dependent manner | GlyT1 inhibitor...
fluorescence was monitored with a FACSCalibur cytometer, using the FL4 channel and at least 10,000 events were collected. The percentage of inhibition was
http://glyt1inhibitor.com/index.php/2017/06/22/we-also-showed-here-that-the-expression-of-necl-4-was-regulated-in-a-cell-density-dependent-manner/
Browsing by Subject Cell-to-cell signalingBrowsing by Subject Cell-to-cell signaling
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with cystic fibrosis (CF). This gram-negative bacterium uses multiple cell-to-cell signals to control ...
https://thescholarship.ecu.edu/browse?value=Cell-to-cell+signaling&type=subject
Sex, prodrugs and rock and roll - Mind HacksSex, prodrugs and rock and roll - Mind Hacks
BBC News has a report on the increasingly popularity of gamma-Butyrolactone or GBL as a recreational drug. Actually, its not a drug in itself, but once ingested it is metabolised into GHB, a drug often sold under the name Liquid Ecstasy. Actually, the effects are much more like alcohol than ecstasy (the street name is…
https://mindhacks.com/2007/12/28/sex-prodrugs-and-rock-and-roll/
Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulatorsCensus and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators
The importance of accurate demographic information is reflected in the United States Constitution, Article 1, which provides for a decennial census of this countrys human population. Bacteria also conduct a census of their population and do so more frequently, more efficiently, and as far we know, …
https://pubmed.ncbi.nlm.nih.gov/8905097/
3-hydroxy-C14 homoserine lactone Mass Spectrum3-hydroxy-C14 homoserine lactone Mass Spectrum
This MassBank Record with Accession RP021802 contains the MS2 mass spectrum of 3-hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide. The mass spectrum was acquired on a LC-ESI-QTOF with POSITIVE ionisation using CID fragmentation with the collision energy 20 at a resolution of null and has the SPLASH splash10-0udi-1900000000-23f306718a9c6f1e71b2.
https://massbank.eu/MassBank/RecordDisplay.jsp?id=RP021802
Perennial Farm MarketplacePerennial Farm Marketplace
We grow our own plants and ship them directly to your door. The fact that we are the grower, allows us to control production and properly care for all plant material prior to shipping. You benefit from this by getting the highest quality plants delivered right to your front door and knowledgeable staff to help answer any garden questions you may have! We gladly accept:. ...
https://www.perennialfarmmarketplace.com/Plant-Color/Chartreuse
Difference between revisions of Dandekar & Chandler:AHL Signal Measuring - OpenWetWareDifference between revisions of Dandekar & Chandler:AHL Signal Measuring - OpenWetWare
During this shaking period label chloroform-resistant tubes or 96 well plate with sample names and dilutions For ease of handling large numbers of eppendorf tubes, we load them in a rack, wrap saran wrap around the tubes + rack, secure the ends with packing tape, and shake the entire rack in the 37°C shaker. Saran wrap can be easily cut off using scissors at the end of the experiment ...
https://openwetware.org/wiki/?title=Dandekar_%252526_Chandler:AHL_Signal_Measuring&diff=prev&oldid=765820
American Financial Services Association - AFSA Letter to House Committee on Oversight and Government Reform
The American Financial Services Association is the national trade association for the consumer credit industry, protecting access to credit and consumer choice
https://afsaonline.org/afsa_resource/afsa-letter-to-house-committee-on-oversight-and-government-reform/
PQR | N-{(1e)-1-amino-5-[(diaminomethylene)amino]-1-hydroxy-1-penten-2-yl}benzamidePQR | N-{(1e)-1-amino-5-[(diaminomethylene)amino]-1-hydroxy-1-penten-2-yl}benzamide
You are viewing an interactive 3D depiction of the molecule n-{(1e)-1-amino-5-[(diaminomethylene)amino]-1-hydroxy-1-penten-2-yl}benzamide (C13H19N5O2) from the PQR.
http://pqr.pitt.edu/mol/YRINIXCRGISJPA-ZHACJKMWSA-N
PQR | N-[4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]-3-hydroxy-2,2-dimethylpropanamidePQR | N-[4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]-3-hydroxy-2,2-dimethylpropanamide
You are viewing an interactive 3D depiction of the molecule n-[4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]-3-hydroxy-2,2-dimethylpropanamide (C23H27N3O4S) from the PQR.
http://pqr.pitt.edu/mol/OSQAKHSYTKBSPB-UHFFFAOYSA-N
Serum Enterolactone and Risk of Breast Cancer | Cancer Epidemiology, Biomarkers & PreventionSerum Enterolactone and Risk of Breast Cancer | Cancer Epidemiology, Biomarkers & Prevention
Phytoestrogens have been linked to a risk of breast cancer. The main phytoestrogens in the Finnish diet are lignans, and enterolactone is quantitatively the most important circulating lignan. The purpose of this study was to examine the association between serum enterolactone and risk of breast cancer in Finnish women. The subjects were participants of the Kuopio Breast Cancer Study. This analysis concerns 194 breast cancer cases (68 premenopausal and 126 postmenopausal) who entered the study before diagnosis and 208 community-based controls. They completed a validated food frequency questionnaire referring to the previous 12 months and gave serum samples before the examinations. The measurement of serum enterolactone was performed by time-resolved fluoroimmunoassay. The statistical analyses were done by the logistic regression method. The mean serum enterolactone concentration was 20 nmol/l for the cases and 26 nmol/l for the controls (P 0.003). The mean serum enterolactone concentration in the ...
https://cebp.aacrjournals.org/content/10/4/339.abstract
Partial molar volumes and partial molar isentropic compressions of γ-Butyrolactone and ε-Caprolactone at infinite dilution in...Partial molar volumes and partial molar isentropic compressions of γ-Butyrolactone and ε-Caprolactone at infinite dilution in...
Density and speed-of-sound values at T = (278.15, 283.15, 288.15, 293.15, 298.15, 308.15, and 318.15) K and at atmospheric pressure were measured, for dilute aqueous solutions of γ-butyrolactone and ε-caprolactone, using an Anton Paar DSA 5000 vibrating-tube densimeter and sound analyzer. A small but significant effect of hydrolysis was observed for aqueous ε-caprolactone and a procedure for eliminating its effect was proposed and employed. Values of the partial molar volume and isentropic compression at infinite dilution were obtained from this experimental data by suitable extrapolation procedures and compared with available data from the literature. The group contribution of the methylene group was evaluated and compared with that obtained for other classes of aqueous cyclic solutes.. ...
https://researchrepository.murdoch.edu.au/id/eprint/32062/
Gamma-hydroxybutyrate and Gamma-butyrolactone Abuse | PatientGamma-hydroxybutyrate and Gamma-butyrolactone Abuse | Patient
Read about Gamma-hydroxybutyrate and Gamma-butyrolactone Abuse, and learn m ore about GBL & GHB abuse on Gamma-hydroxybutyrate and Gamma-butyrolactone Abuse page
https://patient.info/doctor/gamma-hydroxybutyrate-and-gamma-butyrolactone-abuse
Sensors | Free Full-Text | Quorum Sensing Activity of Serratia fonticola Strain RB-25 Isolated from an Ex-landfill SiteSensors | Free Full-Text | Quorum Sensing Activity of Serratia fonticola Strain RB-25 Isolated from an Ex-landfill Site
Quorum sensing is a unique bacterial communication system which permits bacteria to synchronize their behaviour in accordance with the population density. The operation of this communication network involves the use of diffusible autoinducer molecules, termed N-acylhomoserine lactones (AHLs). Serratia spp. are well known for their use of quorum sensing to regulate the expression of various genes. In this study, we aimed to characterized the AHL production of a bacterium designated as strain RB-25 isolated from a former domestic waste landfill site. It was identified as Serratia fonticola using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry analysis and this was confirmed by 16S ribosomal DNA sequencing. High resolution triple quadrupole liquid chromatography-mass spectrometry analysis of S. fonticola strain RB-25 spent culture supernatant indicated the existence of three AHLs namely: N-butyryl-L-homoserine lactone (C4-HSL), N-hexanoyl-L-homoserine lactone (C6
http://www.mdpi.com/1424-8220/14/3/5136/xml
Structural and biochemical characterization of AidC, a quorum-quenching lactonase with atypical selectivity (Journal Article) |...Structural and biochemical characterization of AidC, a quorum-quenching lactonase with atypical selectivity (Journal Article) |...
Quorum-quenching catalysts are of interest for potential application as biochemical tools for interrogating interbacterial communication pathways, as antibiofouling agents, and as anti-infective agents in plants and animals. Herein, the structure and function of AidC, an N-acyl-l-homoserine lactone (AHL) lactonase from Chryseobacterium, is characterized. Steady-state kinetics show that zinc-supplemented AidC is the most efficient wild-type quorum-quenching enzymes characterized to date, with a k cat/K M value of approximately 2 × 10 6 M -1 s -1 for N-heptanoyl-l-homoserine lactone. The enzyme has stricter substrate selectivity and significantly lower KM values (ca. 50 μM for preferred substrates) compared to those of typical AHL lactonases (ca. ,1 mM). X-ray crystal structures of AidC alone and with the product N-hexanoyl-l-homoserine were determined at resolutions of 1.09 and 1.67 Å, respectively. Each structure displays as a dimer, and dimeric oligiomerization was also observed in solution ...
https://www.osti.gov/scitech/biblio/1263637-structural-biochemical-characterization-aidc-quorum-quenching-lactonase-atypical-selectivity
Team:BIOTEC Dresden/Literature - 2010.igem.orgTeam:BIOTEC Dresden/Literature - 2010.igem.org
1.THE GREEN FLUORESCENT PROTEIN - Annual Review of Biochemistry, 67(1):509.. 2.Tian T, Burrage K (2006) Stochastic models for regulatory networks of the genetic toggle switch. Proceedings of the National Academy of Sciences 103: 8372 -8377.. 3.Basu S, Mehreja R, Thiberge S, Chen M, Weiss R (2004) Spatiotemporal control of gene expression with pulse-generating networks. Proceedings of the National Academy of Sciences of the United States of America 101: 6355 -6360.. 4.Nilsson P, Olofsson A, Fagerlind M, Fagerström T, Rice S, u. a. (2001) Kinetics of the AHL Regulatory System in a Model Biofilm System: How Many Bacteria Constitute a Quorum? Journal of Molecular Biology 309: 631-640.. 5.Schaefer AL, Val DL, Hanzelka BL, Cronan JE, Greenberg EP (1996) Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein. Proc. Natl. Acad. Sci. U.S.A 93: 9505-9509.. 6.Kaplan HB, Greenberg EP (1985) Diffusion of autoinducer is ...
http://2010.igem.org/wiki/index.php?title=Team:BIOTEC_Dresden/Literature&diff=prev&oldid=205132
A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. - PubMed - NCBIA Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/15554963?dopt=Abstract
IJMS | Free Full-Text | Intra-Species Bacterial Quorum Sensing Studied at Single Cell Level in a Double Droplet Trapping SystemIJMS | Free Full-Text | Intra-Species Bacterial Quorum Sensing Studied at Single Cell Level in a Double Droplet Trapping System
In this paper, we investigated the intra-species bacterial quorum sensing at the single cell level using a double droplet trapping system. Escherichia coli transformed to express the quorum sensing receptor protein, LasR, were encapsulated in microdroplets that were positioned adjacent to microdroplets containing the autoinducer, N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL). Functional activation of the LasR protein by diffusion of the OdDHL across the droplet interface was measured by monitoring the expression of green fluorescent protein (GFP) from a LasR-dependent promoter. A threshold concentration of OdDHL was found to induce production of quorum-sensing associated GFP by E. coli. Additionally, we demonstrated that LasR-dependent activation of GFP expression was also initiated when the adjacent droplets contained single E. coli transformed with the OdDHL synthase gene, LasI, representing a simple quorum sensing circuit between two droplets.
http://mdpi.com/1422-0067/14/5/10570/xml
The bacterial enigma: cracking the code of cell-cell communication - Salmond - 1995 - Molecular Microbiology - Wiley Online...The bacterial enigma: cracking the code of cell-cell communication - Salmond - 1995 - Molecular Microbiology - Wiley Online...
In recent years it has become clear that the production of N-acyl homoserine lactones (N-AHLs) is widespread in Gram-negative bacteria. These molecules act as diffusible chemical communication signals (bacterial pheromones) which regulate diverse physiological processes including bioluminescence, antibiotic production, piasmid conjugal transfer and synthesis of exoenzyme virulence factors in plant and animal pathogens. The paradigm for N-AHL production is in the bioluminescence (lux) phenotype of Photobacterium fischeri (formerly classified as Vibrio fischeri) where the signalling molecule N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) is synthesized by the action of the Luxl protein. OHHL is thought to bind to the LuxR protein, allowing it to act as a positive transcriptional activator in an autoinduction process that physiologically couples cell density (and growth phase) to the expression of the bioluminescence genes. Based on the growing information on Luxl and LuxR homologues in other ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.1995.tb02424.x/abstract
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa | PNASQuinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa | PNAS
We have discovered that P. aeruginosa produces a cell-to-cell signal that is unlike any previously reported intercellular signal molecule. This molecule was determined to have a 4-quinolone base structure and therefore has been designated as the Pseudomonas quinolone signal (PQS). Our results showed that exogenously added PQS induced a lasB′-lacZ fusion in the P. aeruginosa lasR mutant, strain PAO-R1, containing the plasmid pTS400 (Fig. 2A). This indicates that there is a third cell-to-cell signal, in addition to the autoinducers 3-oxo-C12-HSL and C4-HSL, that is involved in lasB induction by P. aeruginosa. Despite the ability of PQS to activate lasB′-lacZ in the absence of lasR, the production of PQS required an active LasR protein (Fig. 2A). This suggested that a gene (or genes) required for PQS synthesis is controlled through the las quorum sensing system. We also found that at least RhlR was required for PQS to act as a signal because lasB′-lacZ was not induced by PQS in the lasR, rhlR ...
https://www.pnas.org/content/96/20/11229?ijkey=55c6a6ad486c8cb3d1824010b9e412ff82263cac&keytype2=tf_ipsecsha
Whole genome sequencing enables the characterization of BurI, a LuxI homologue of Burkholderia cepacia strain GG4 [PeerJ]Whole genome sequencing enables the characterization of BurI, a LuxI homologue of Burkholderia cepacia strain GG4 [PeerJ]
Quorum sensing is a mechanism for regulating proteobacterial gene expression in response to changes in cell population. In proteobacteria, N-acyl homoserine lactone (AHL) appears to be the most widely used signalling molecules in mediating, among others, the production of extracellular virulence factors for survival. In this work, the genome of B. cepacia strain GG4, a plasmid-free strain capable of AHL synthesis was explored. In silico analysis of the 6.6 Mb complete genome revealed the presence of a LuxI homologue which correspond to Type I quorum sensing. Here, we report the molecular cloning and characterization of this LuxI homologue, designated as BurI. This 609 bp gene was cloned and overexpressed in Escherichia coli BL21(DE3). The purified protein was approximately 25 kDa and is highly similar to several autoinducer proteins of the LuxI family among Burkholderia species. To verify the AHL synthesis activity of this protein, high resolution liquid chromatography-mass spectrometry analysis
https://peerj.com/articles/1117/
IJPBS Article- EVALUATION OF THE POTENTIAL OF FIVE MEDICINAL PLANTS TO INHIBIT ACYL HOMOSERINE LACTONE BASED QUORUMIJPBS Article- EVALUATION OF THE POTENTIAL OF FIVE MEDICINAL PLANTS TO INHIBIT ACYL HOMOSERINE LACTONE BASED QUORUM
Archives issue of International Journal of Pharma and Bio Sciences which aims to cover the latest outstanding developments in the field of pharmaceutical and biological sciences
http://www.ijpbs.net/details.php?article=2269
Cyclic AMP and Acyl Homoserine Lactones Increase the Cultivation Efficiency of Heterotrophic Bacteria from the Central Baltic...Cyclic AMP and Acyl Homoserine Lactones Increase the Cultivation Efficiency of Heterotrophic Bacteria from the Central Baltic...
Implications for the application of the MPN technique.It has been shown that cellular isolates which correspond to abundant 16S rDNA sequences can indeed be isolated if the inocula are diluted in MPN series prior to enrichment (16). This effect has been attributed to the presence of rare but rapidly growing bacteria which are eliminated by the dilution step. Consequently, the MPN technique currently represents the method of choice to obtain cultures of abundant bacteria (16).. Unexpectedly, isolates obtained in the present study from the highest positive dilutions, despite the very high cultivation success of up to 100%, could not be detected by DGGE fingerprinting and yielded only a very faint signal during dot blot hybridization. Based on the relatively large inherent statistical uncertainty of the MPN technique, the fraction of strain G100 in the natural bacterioplankton community could also be as low as 12% (the lower limit of the MPN confidence interval). Nevertheless, this minimum value is ...
https://aem.asm.org/content/68/8/3978?ijkey=56f0cb5d1ac810cebfc58cf08d7d747287968c2a&keytype2=tf_ipsecsha
Induction of systemic resistance, root colonisation and biocontrol activities of the rhizospheric strain ofSerratia...Induction of systemic resistance, root colonisation and biocontrol activities of the rhizospheric strain ofSerratia...
Quorum sensing regulation, mediated by N-acyl homoserine lactone signals, produced by strain Serratia plymuthica HRO-C48 isolated from the rhizosphere of oilseed rape, was found to be responsible for
https://link.springer.com/article/10.1007%2Fs10658-008-9411-1
HA-1077 - Fatty Acid Synthase Inhibitors Induce ApoptosisHA-1077 - Fatty Acid Synthase Inhibitors Induce Apoptosis
Rabbit polyclonal to TranscriptionfactorSp1. SLN-CTAb does not cross-react with any other low molecular protein in particular PLB. SLN could not be detected with total ventricular protein extract because of its very low level suggesting that microsomal fractions should be used to detect SLN in the ventricle. These results together suggest HA-1077 that we effectively produced a rabbit-polyclonal antibody particular for SLN which identifies SLN across varieties. Shape 1 (A) European blot evaluation of sarcolipin (SLN) and phospholamban (PLB) in the full total homogenate (Total), SR enriched microsomal fractions (SR) and post microsomal fractions (PM) from rat atria and ventricle. Bacterial draw out including rat and human being SLN … The manifestation design of SLN differs between little and bigger mammals To determine whether SLN proteins expression comes after its mRNA design HA-1077 [2-5], total proteins prepared from different muscle groups of mouse, rat, pet and rabbit were analyzed by ...
https://aksumuniversity.org/tag/ha-1077/
We describe novel imaging protocols that allow detection of small cancer - Fatty Acid Synthase Inhibitors Induce ApoptosisWe describe novel imaging protocols that allow detection of small cancer - Fatty Acid Synthase Inhibitors Induce Apoptosis
We describe novel imaging protocols that allow detection of small cancer cell colonies deep inside tissue phantoms with high sensitivity and specificity. to deeper tumors. We show that under these conditions Syryl-9M can detect as few as 10 cells in a biologically relevant phantom. This outstanding characteristic should bode very well for development of new highly efficient near-IR clinical imaging agents. 2. Methods 2.1. Cells and cell culture For our collagen gel phantom experiments, we required cell lines that we knew from experience would not be adversely affected by culturing in three dimensional collagen type I gels. This was true of all the cell lines used in this work. Three of the lines, normal mammary, +SA and 4T1, were also derived from the same BALB/c inbred mouse strain. The MDA-MB-231 and NIHOVCAR3 cells were chosen to represent malignant human cell lines. Passage Ambrisentan two, normal mouse mammary epithelial cells were propagated from cells obtained from Dr. H. L. Hosick in ...
http://aksumuniversity.org/we-describe-novel-imaging-protocols-that-allow-detection-of-small-cancer/
Home | Blackwell LabHome | Blackwell Lab
Virulence in the Gram-negative pathogen Pseudomonas aeruginosa relies in part on the efficient functioning of two LuxI/R dependent quorum sensing (QS) cascades, namely, the LasI/R and RhlI/R systems that generate and respond to N-(3-oxo)-dodecanoyl-l-homoserine lactone and N-butyryl-l-homoserine lactone, respectively. The two acyl homoserine lactone (AHL) synthases, LasI and RhlI, use 3-oxododecanoyl-ACP and butyryl-ACP, respectively, as the acyl-substrates to generate the corresponding autoinducer signals for the bacterium. Although AHL synthases represent excellent targets for developing QS modulators in P. aeruginosa, and in other related bacteria, the identification of potent and signal synthase specific inhibitors has represented a significant technical challenge. In the current study, we sought to test the utility of AHL analogs as potential modulators of an AHL synthase and selected RhlI in P. aeruginosa as an initial target. We systematically varied the chemical functionalities of the ...
https://blackwell.chem.wisc.edu/
acyl-homoserine lactone | mBioacyl-homoserine lactone | mBio
Specific recognition of cognate signals is considered fundamental to cell signaling circuits as it creates fidelity in the communication system. In bacterial quorum sensing (QS), receptor specificity ensures that bacteria cooperate only with kin. There are examples, however, of QS receptors that respond promiscuously to multiple signals. Eavesdropping by these promiscuous receptors can be beneficial in both interspecies competition... ...
https://mbio.asm.org/keyword/acyl-homoserine-lactone
Generation of High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones | SpringerLinkGeneration of High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones | SpringerLink
A number of bacteria use a class of chemical compounds called acyl-homoserine lactones (AHLs) as quorum sensing (QS) signals to coordinate their behavior at the population level, including pathogens...
https://link.springer.com/protocol/10.1007/978-1-4939-7309-5_25
Thiourea-catalyzed aminolysis of N-acyl homoserine lactonesThiourea-catalyzed aminolysis of N-acyl homoserine lactones
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
https://www.growkudos.com/publications/10.1039%25252Fc3cc00268c/reader
Chapter 893 Section 031 - 2016 Florida Statutes - The Florida SenateChapter 893 Section 031 - 2016 Florida Statutes - The Florida Senate
e) A person who extracts or synthesizes either 1,4-Butanediol or gamma-butyrolactone (GBL) from a finished product as described in subparagraph(1)(j)2. or a person who extracts or synthesizes 1,4-Butanediol or gamma-butyrolactone (GBL) from any product or material, unless such extraction or synthesis is authorized by law; or ...
http://www.flsenate.gov/Laws/Statutes/2016/893.031
Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N -(3...Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N -(3...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_jm2001019
Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
The use of natural products is becoming increasingly popular worldwide. Flaxseed is a source of natural products that are rich with bioactives and have been reported to modulate inflammation, blood pressure, glucose levels and lipid profiles in both humans and animals. Currently, several known bioactives including fibers, lignans, alpha-linolenic acid, and linoorbitides (LOBs) are believed to impart those pharmacological activities. Previous studies have focused on the ability of flaxseed bioactives to provide their pharmacological action in the systemic circulation. However, our increasing understanding of their pharmacokinetics and chemical structures, suggests enhanced abundance of LOBs and lignans at the level of the intestinal epithelium due to the potential lack of permeation of LOBs, and susceptibility of lignans to enterohepatic circulation. Our aim in this work is to evaluate the effects of the lignan enterolactone (ENL) and LOBs on intestinal epithelium function and how it might ...
https://ecommons.usask.ca/handle/10388/7781
Anti Acne Drugs Manufacturers, Anti Acne Drugs Suppliers, Exporters in USA
Inter Steroids Pharmaceutical Co.LTD provide the Anti Acne Drugs like Isotretinoin Powder, Finasteride Powder, Gamma Butyrolactone etc. We are exporters, suppliers & manufacturers of all these products.
http://m.ispharmaceuticals.com/anti-acne-drugs.html
Druglink factsheet 2014 - GBL - DrugWiseDruglink factsheet 2014 - GBL - DrugWise
GBL (gamma-butyrolactone) is a pro-drug of GHB, which means that it converts to GHB within the body. GBL occurs naturally in certain food products, is found in small quantities in the human body and is available commercially as an industrial solvent and as an ingredient in cleaners, paint removers and engine degreasers.. Factsheet GBL (PDF). ...
http://www.drugwise.org.uk/druglink-factsheet-2014-gbl/
Overdose of Gamma-Hydroxybutyrate (GHB) - Neurology AdvisorOverdose of Gamma-Hydroxybutyrate (GHB) - Neurology Advisor
As noted, GHB is a derivative of the endogenous substance GABA and will be present in patients even in the absence of GHB ingestion. GHB as a sodium salt is also available as a therapeutic drug for treatment of narcolepsy. In addition, Gamma-butyrolactone (GBL) and 1,4-butanedial (BD) are chemicals metabolized to GHB in the body if they are ingested orally. In some cases, patients may have obtained these substances, rather than GHB, for self-administration, because they may not be banned by law, depending on the country in question.. Most methods for GHB detection are chromatographic and performed in reference labs, and, therefore, the long turnaround time makes it difficult for the testing to have a direct impact in patient management. These types of methods are not prone to interference by structural analogs and other compounds that may be present in a patient specimen. There is one direct enzymatic assay available based on GHB dehydrogenase, and this method does exhibit some interference from ...
https://www.neurologyadvisor.com/decision-support-in-medicine/labmed/overdose-of-gamma-hydroxybutyrate-ghb/
High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones Protect Mice from Lethal Pseudomonas aeruginosa...High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones Protect Mice from Lethal Pseudomonas aeruginosa...
In P. aeruginosa chronic infections, autoinducer concentrations in patient samples vary among different strains, and accurate values are still unknown. However, in one report, the levels of extractable 3-oxo-C12-HSL and C4-HSL in the sputum of CF patients were in the nanomolar range: up to 22 nM for 3-oxo-C12-HSL and 0 to 5 nM for C4-HSL (29). This is considerably lower than the concentrations required for exerting cytotoxicity in mammalian cells (10 to 50 μM) (30) and also the levels found in planktonic P. aeruginosa cultures (1 μM) (31) and in vitro biofilms (600 μM) (32). It has been widely accepted that antibodies with subnanomolar affinity exhibit improved therapeutic efficacy, especially if the targets to be bound are present in low concentrations (33). Clearly, nanomolar levels of HSL compounds in patient lungs cannot be ruled out, although these lower levels observed might have been influenced analytically by factors such as the unstable nature of these compounds in the extracellular ...
https://aem.asm.org/content/80/2/462
The GABA Defense | Science SignalingThe GABA Defense | Science Signaling
During infection of plants by Agrobacterium tumefaciens, plants are wounded and then a tumor is induced, which is a source of opines, chemicals that stimulate the production of the quorum-sensing (QS) signal N-(3-oxooctanoyl)homoserine lactone (OC8-HSL). γ-aminobutyric acid (GABA) is produced by plants as part of the response to wounding. Chevrot et al. show that GABA stimulates expression of the attKLM operon in A. tumefaciens, which produces a lactonase that inactivates OC8-HSL. OC8-HSL was undetectable in cultures of A. tumefaciens exposed to GABA. Proteins encoded by the attKLM operon were identified in a proteomic screen for proteins synthesized in response to the addition of GABA to cultures of A. tumefaciens. The induction of the attKLM operon was also monitored using a reporter assay, and in A. tumefaciens deficient for the GABA transporter system, GABA did not induce the reporter. The importance of GABA for the plant response was verified using a transgenic tobacco that expressed a ...
https://stke.sciencemag.org/content/2006/335/tw164
ChemInform Abstract: Asymmetric Vinylogous Michael Reaction of α,β-Unsaturated Ketones with γ-Butenolide under Multifunctional...ChemInform Abstract: Asymmetric Vinylogous Michael Reaction of α,β-Unsaturated Ketones with γ-Butenolide under Multifunctional...
ChemInform Abstract: Asymmetric Vinylogous Michael Reaction of α,β-Unsaturated Ketones with γ-Butenolide under Multifunctional Catalysis.|span||/span| | Huicai Huang; Feng Yu; Zhichao Jin; Wenjun Li; Wenbin Wu; Xinmiao Liang; Jinxing Ye | download | BookSC. Download books for free. Find books
http://booksc.org/book/1071631/fe3571/?_ir=1
Widok | FH-Prof. Dr. Julian Weghuber
R. Wagner, G. Stübiger, D. Veigel, M. Wuczkowski, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger, C. Singer, R. Colomer, B. Benhamu, M. Lopez-Rodrguez, P. Valent, T. Grunt - Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells - Oncotarget, Vol. 8, No. 7, ...
http://research.fh-ooe.at/de/staff/29869
The GABA Defense | ScienceThe GABA Defense | Science
During infection of plants by Agrobacterium tumefaciens, plants are wounded and then a tumor is induced, which becomes a source of opines: chemicals that stimulate the production of the quorum-sensing (QS) signal N-(3-oxooctanoyl) homoserine lactone (OC8-HSL). γ-aminobutyric acid (GABA) is produced by plants as part of the response to wounding. Chevrot et al. show that GABA stimulates expression of the attKLM operon in A. tumefaciens, which produces a lactonase that opens the ring and inactivates OC8-HSL. Consequently, OC8-HSL was undetectable in cultures of A. tumefaciens exposed to GABA. Proteins encoded by the attKLM operon were identified in a screen for proteins synthesized in response to the addition of GABA to cultures of A. tumefaciens. The induction of the attKLM operon was also monitored using a reporter assay, and in A. tumefaciens deficient for the GABA transporter system, GABA did not induce the reporter. The importance of GABA for the plant response was verified using transgenic ...
http://science.sciencemag.org/content/312/5777/1109.2
Gamma-ButyrolactoneGamma-Butyrolactone
... , γ-Butyrolactone (GBL) is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor. ... Gamma-Butyrolactone is often referred to be used as a date rape drug. Frequent use of GHB or GBL, even when taken long-term and ... "Gamma-butyrolactone (GBL) Pre-Review Report" (PDF). 4 June 2012. Van Cauter, E.; Plat, L.; Scharf, M. B.; Leproult, R.; ... γ-Butyrolactone is produced industrially by dehydrogenation of 1,4-butanediol at a temperature of 180-300 °C and atmospheric ...
https://en.wikipedia.org/wiki/Gamma-Butyrolactone
Gamma-Hydroxybutyric acidGamma-Hydroxybutyric acid
Both γ-butyrolactone (GBL) and 1,4-butanediol are converted to GHB in the body. In January 2016, it was announced scientists ... Some prodrugs, such as γ-butyrolactone (GBL), convert to GHB in the stomach and blood stream. Other prodrugs exist, such as 1,4 ... Elliott S, Burgess V (July 2005). "The presence of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in alcoholic ... γ-butyrolactone and 1,4-butanediol". Clinical Toxicology. 50 (6): 458-70. doi:10.3109/15563650.2012.702218. PMID 22746383. ...
https://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid
EmbutramideEmbutramide
Amide formation via reaction with gamma-butyrolactone completed the synthesis of embutramide (4). Elks J (14 November 2014). ... 31 (4): 319-20. PMID 2815545. Kintz P, Cirimele V, Ludes B (October 2002). "Blood investigation in a fatality involving the ... Archived from the original (PDF) on 4 March 2017. Hellebrekers LJ, Baumans V, Bertens AP, Hartman W (July 1990). "[The use of ... 315-. ISBN 978-0-323-24198-4. US 3045043, Schmitt K, Henning I, Lindner E, Ott H, "New gamma-hydroxy-carboxylic acid amides and ...
https://en.wikipedia.org/wiki/Embutramide
2-Acetylbutyrolactone2-Acetylbutyrolactone
... (ABL) is a derivative of γ-butyrolactone that is used as a precursor in organic synthesis, and it is used ... with butyrolactone in an alkaline solution. 2-Acetylbutyrolactone can also be prepared by reacting ethylene oxide with ethyl ... "Method for Preparing 2-Acetyl-y-Butyrolactone". United States Patent. Archived from the original on 2022-03-31. Retrieved March ... Unnikrishnan, P,A (1992). "Syntheses of epi-β-Santalene, β-Santalene and an Isomer of β-Santalene with 4-Methyl-4-pentenyl Side ...
https://en.wikipedia.org/wiki/2-Acetylbutyrolactone
Expanding monomerExpanding monomer
Also a condensation analogous to acetalisation reaction is possible.: 83 An ethanediol derivate and γ-butyrolactone are ... 49 The epoxide cyclohexene oxide and the lactone γ-butyrolactone are reacting to the spiro orthoester spiro-7-9-dioxacyclo[4.3. ... Hsu, Ying-Gev; Wan, Yen-Shen (15 July 2009). "Cationic photopolymerization of cis-2,3-tetramethylene-1,4,6-trioxaspiro[4,4] ... reacting to a derivate of 1,4,6-trioxa-spiro[4.4]nonane. The third possibility is using dibutyltin oxide and carbon disulfide ...
https://en.wikipedia.org/wiki/Expanding_monomer
Gamma-ValerolactoneGamma-Valerolactone
... γ-Butyrolactone (GBL) NIH National Toxicology Program Baird, Zachariah Steven; Uusi-Kyyny, Petri; Pokki, Juha-Pekka; Pedegert, ... 37 (4): 250-4. doi:10.1093/jat/bkt013. PMID 23486087. Fred Smith (31 December 2004). Handbook of Forensic Drug Analysis. ...
https://en.wikipedia.org/wiki/Gamma-Valerolactone
PolyorthoesterPolyorthoester
The degradation of the polymer chain sets free the initial diol and γ-butyrolactone, which is further hydrolyzed to 4- ... synthesized from γ-butyrolactone and triethylorthoformate). In polycondensation small molecules are formed (in this case of ... The 4-hydroxybutanoic acid formed is responsible for the locally lowered pH value upon polymer degradation. The commercial use ... 4, pp. 770-772, Bibcode:1997MaMol..30..770N, doi:10.1021/ma9610626 J. Heller; J. Barr (2004), "Poly(ortho esters) - from ...
https://en.wikipedia.org/wiki/Polyorthoester
SCH-50911SCH-50911
August 2006). "Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4- ... butanediol (1,4-BD) in different rat lines". Annals of the New York Academy of Sciences. 1074: 545-58. doi:10.1196/annals. ...
https://en.wikipedia.org/wiki/SCH-50911
1,4-Butanediol1,4-Butanediol
At about 200 °C in the presence of soluble ruthenium catalysts, the diol undergoes dehydrogenation to form butyrolactone. It is ... gamma-butyrolactone) as a Class C controlled substance. In Germany, the drug is not explicitly illegal, but might also be ... 1,4-Butanediol is also used as a recreational drug known by some users as "One Comma Four", "Liquid Fantasy", "One Four Bee" or ... 1,4-Butanediol was detected by GC-MS. The production plant seems to have intended to cut costs by replacing less toxic 1,5- ...
https://en.wikipedia.org/wiki/1,4-Butanediol
Diisopropyl etherDiisopropyl ether
Shoji Hara, Akira Suzuk (1998). "Synthesis of 4-(2-Bromo-2-Propenyl)-4-Methyl-Y-Butyrolactone by the Reaction of Ethyl ...
https://en.wikipedia.org/wiki/Diisopropyl_ether
3,4-Epoxycyclohexylmethyl-3,4-epoxycyclohexane carboxylate3,4-Epoxycyclohexylmethyl-3',4'-epoxycyclohexane carboxylate
"Improved thermosets obtained from cycloaliphatic epoxy resins and γ-butyrolactone with lanthanide triflates as initiators. I. ... 3,4-Epoxycyclohexylmethyl-3',4'-epoxycyclohexane carboxylate (ECC) is a cycloaliphatic epoxy resin which is used in many ... Record of 3,4-Epoxycyclohexylmethyl-3',4'-epoxycyclohexancarboxylat in the GESTIS Substance Database of the Institute for ... 4′-epoxycyclohexancarboxylate in photoinitiated cationic polymerizations". Journal of Polymer Science Part A: Polymer Chemistry ...
https://en.wikipedia.org/wiki/3,4-Epoxycyclohexylmethyl-3',4'-epoxycyclohexane_carboxylate
List of MeSH codes (D03)List of MeSH codes (D03)
4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 - epirizole MeSH D03.383.129.539.487 - ... 4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH D03.383.312.649.313 - furazolidone MeSH ... 4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.210 - dimethindene MeSH D03.383. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
GABA receptor agonistGABA receptor agonist
4-Butanediol Baclofen GABA Gabamide GABOB gamma-Butyrolactone (GBL) gamma-Hydroxybutyric acid (GHB) gamma-Hydroxyvaleric acid ( ... GHV) gamma-Valerolactone (GVL) Lesogaberan Phenibut 4-Fluorophenibut Picamilon Progabide SL-75102 Tolgabide ADX-71441 CACA CAMP ...
https://en.wikipedia.org/wiki/GABA_receptor_agonist
C4H6O2C4H6O2
The molecular formula C4H6O2 may refer to: 1,4-Butynediol Butyrolactones β-Butyrolactone γ-Butyrolactone Crotonic acid Diacetyl ... Diepoxybutane 1,4-Dioxene Isocrotonic acid Methacrylic acid Methyl acrylate Succinaldehyde Vinyl acetate Butenoic acid This set ...
https://en.wikipedia.org/wiki/C4H6O2
1,2,4-Butanetriol1,2,4-Butanetriol
... by using 3-hydroxy-gamma-butyrolactone as a chiral synthon It is used as one of the monomers for manufacture of some polyesters ... 1,2,4-Butanetriol is also used as a precursor for two cholesterol-lowering drugs, Crestor and Zetia, which are derived from D-3 ... 1,2,4-Butanetriol is a clear or slightly yellow, odorless, hygroscopic, flammable, viscous liquid. It is an alcohol with three ... 1,2,4-Butanetriol can be prepared synthetically by several different methods such as hydroformylation of glycidol and ...
https://en.wikipedia.org/wiki/1,2,4-Butanetriol
Gamma-Hydroxyvaleric acidGamma-Hydroxyvaleric acid
γ-Valerolactone (GVL) acts as a prodrug to GHV, analogously to how γ-butyrolactone (GBL) is a prodrug to GHB. 1,4-Butanediol (1 ... 37 (4): 250-4. doi:10.1093/jat/bkt013. PMID 23486087. v t e (Drugs with non-standard legal status, ECHA InfoCard ID from ... γ-Hydroxyvaleric acid (GHV), also known as 4-methyl-GHB, is a designer drug related to γ-hydroxybutyric acid (GHB). It is ... 4-BD) Aceburic acid Valerenic acid Valeric acid Carter LP; Chen W; Wu H; Mehta AK; Hernandez RJ; Ticku MK; Coop A; Koek W; ...
https://en.wikipedia.org/wiki/Gamma-Hydroxyvaleric_acid
Aceburic acidAceburic acid
7-dione γ-Butyrolactone (GBL) γ-Hydroxybutyraldehyde (GHBAL) γ-Valerolactone (GVL) Aceturic acid Aceglutamide Ethyl acetoxy ... It is the acetyl ester of gamma-hydroxybutyrate (GHB, which is 4-hydroxybutanoic acid), and based on its structural relation to ... Aceburic acid (INN), also known as 4-acetoxybutanoic acid or 4-hydroxybutyric acid acetate, is drug described as an analgesic ... 1052-. ISBN 978-0-412-46630-4. v t e (Articles with short description, Short description matches Wikidata, Drugs not assigned ...
https://en.wikipedia.org/wiki/Aceburic_acid
Succinic acidSuccinic acid
Gamma-Butyrolactone & Polyurethanes), And Segment Forecasts To 2020". Grand View Research. September 2015. Retrieved 2015-11-18 ... 1,4-Butanediol (BDO) can be synthesized using succinic acid as a precursor. The automotive and electronics industries heavily ... This enzyme complex is a 4 subunit membrane-bound lipoprotein which couples the oxidation of succinate to the reduction of ... In humans, three HIF prolyl 4-hydroxylases regulate the stability of HIFs. Hydroxylation of two prolyl residues in HIF1α ...
https://en.wikipedia.org/wiki/Succinic_acid
1-Tetralone1-Tetralone
The AlCl3-catalyzed acylation of benzene with γ-butyrolactone produces 1-tetralone. 1-Tetralone can be reduced via a Birch ... 4-Phenylbutanoic acid can also be quantitatively converted into 1-tetralone by heating in the presence of a strong Lewis acid ... 4-Phenylbutanoic acid chlorides with electron-donating groups can be cyclized to 1-tetralones under mild reaction conditions in ... 4, pp. 249-266, doi:10.1016/S2225-4110(16)30111-0, PMC 3942903, PMID 24716140 H. Hock; W. Susemihl (1933), "Autoxydation von ...
https://en.wikipedia.org/wiki/1-Tetralone
Ethyl acetoxy butanoateEthyl acetoxy butanoate
It is synthesised by the reaction of gamma-butyrolactone and ethyl acetate with sodium ethoxide. 1,4-Butanediol (1,4-BD) 1,6- ... doi:10.1021/jf00016a014 常温下4-乙酰氧基丁酸乙酯的催化合成方法. 1994. CN1047589C v t e (Articles without InChI source, Articles without
https://en.wikipedia.org/wiki/Ethyl_acetoxy_butanoate
Fischer carbeneFischer carbene
Casey, Charles P.; Brunsvold, William R. (December 1975). "Synthesis of α-methylene-γ-butyrolactone via transition metal ...
https://en.wikipedia.org/wiki/Fischer_carbene
Smart cosubstrateSmart cosubstrate
The formation of a thermodynamically stable gamma-butyrolactone as a co-product drives the reaction to completion while ... ChemCatChem 6 (4):973-976. doi:10.1002/cctc.201300841 Zuhse R, Leggewie C, Hollmann F, Kara S (2015) Scaling-Up of "Smart ... The use of 1,4-butanediol as an intelligent cosubstrate has also been validated in non-aqueous media using a commercial ADH. ... The use of 1,4-butanediol as a smart cosubstrate for cofactor regeneration was the next step towards more sustainable redox ...
https://en.wikipedia.org/wiki/Smart_cosubstrate
Ethanol fermentationEthanol fermentation
... phenylethyl alcohol and gamma-butyrolactone, secondary products of alcoholic fermentation". Comptes Rendus de l'Académie des ... 79 (4): 283-88. doi:10.1002/j.2050-0416.1973.tb03541.x. Ribéreau-Gayon, P.; Sapis, J. C. (2019). "On the presence in wine of ...
https://en.wikipedia.org/wiki/Ethanol_fermentation
BeerBeer
... phenylethyl alcohol and gamma-butyrolactone, secondary products of alcoholic fermentation". Comptes Rendus de l'Académie des ... 79 (4): 283-288. doi:10.1002/j.2050-0416.1973.tb03541.x. Ribéreau-Gayon, P.; Sapis, J. C. (1965). "On the presence in wine of ... Roger Protz (4 December 2004). "The Complete Guide to World Beer". Archived from the original on 25 April 2011. Retrieved 21 ... In Belgium, some beers, such as table beer are of such low alcohol content (1%-4%) that they are served instead of soft drinks ...
https://en.wikipedia.org/wiki/Beer
IARC group 2BIARC group 2B
Bleomycin Bracken fern Bromochloroacetic acid Bromodichloromethane 1-Bromopropane Butylated hydroxyanisole β-Butyrolactone ... 1 Heptachlor Hexachlorobenzene Hexachloroethane Hexachlorocyclohexanes Hexamethylphosphoramide (HMPA) 2,4-Hexadienal Human ... 4,6-Trichlorophenol Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole) ... 4-Diaminotoluene Dibenz[a,h]acridine Dibenz[c,h]acridine 7H-Dibenzo[c,g]carbazole Dibenzo[a,e]pyrene Dibenzo[a,h]pyrene Dibenzo ...
https://en.wikipedia.org/wiki/IARC_group_2B
HeleninHelenin
A comparative study of human and animal sensitivity to alpha-methylene-gamma-butyrolactone and derivatives". The British ... 66 (4): 186-9. doi:10.1016/s0367-326x(99)00122-7. PMID 20095126. Stampf, J (August 1978). "Allergic contact dermatitis due to ...
https://en.wikipedia.org/wiki/Helenin
RitanserinRitanserin
Condensation of this β-keto lactone can be visualized to involve initial attack on the reactive butyrolactone by the primary ... 117-. ISBN 978-0-8247-5660-4. Atkin T, Comai S, Gobbi G (April 2018). "Drugs for Insomnia beyond Benzodiazepines: Pharmacology ... 4). Halogenation of the terminal alcohol with phosphorus oxychloride then yields 6-(2-chloroethyl)- 7-methyl-5H-thiazolo[3,2-a] ... 4-fluorophenyl)methylene)piperidine, [58113-36-3] (6) would complete the synthesis of ritanserin (7). Ketanserin Setoperone J. ...
https://en.wikipedia.org/wiki/Ritanserin
Streptomyces virginiaeStreptomyces virginiae
Kinoshita, H; Ipposhi, H; Okamoto, S; Nakano, H; Nihira, T; Yamada, Y (November 1997). "Butyrolactone autoregulator receptor ... 155 (Pt 4): 1250-9. doi:10.1099/mic.0.022467-0. PMID 19332826. Hopwood, David A. (2007). Streptomyces in nature and medicine : ... ISBN 978-4-431-54607-8. List of Streptomyces species LPSN bacterio.net Straininfo of Streptomyces virginiae UniProt Deutsche ... ISBN 3-642-75617-4. {{cite book}}: ,first1= has generic name (help) Atta-ur-Rahman, edited by (1997). Studies in Natural ...
https://en.wikipedia.org/wiki/Streptomyces_virginiae
List of EC numbers (EC 1)List of EC numbers (EC 1)
A-factor type γ-butyrolactone 1′-reductase (1S-forming) EC 1.1.1.414: L-galactonate 5-dehydrogenase EC 1.1.1.415: noscapine ... EC 1.14.13.141: Now EC 1.14.15.29, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] EC 1.14.13.142 ... 4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] * *No Wikipedia article EC 1.3.2.1: now EC 1.3.99.2 EC 1.3.2.2: now EC 1.3. ... 4-chlorinase * *No Wikipedia article EC 1.14.21.1: Now EC 1.14.19.64, (S)-stylopine synthase EC 1.14.21.2: Now EC 1.14.19.65, ( ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_1)
Tetronic acidTetronic acid
... and abyssomicins possess the β-keto-γ-butyrolactone motif of tetronic acid. In organic synthesis, it is used as a precursor for ... 2,4(3H,5H)-Furandione: Heteroannulations with aromatic o-amino carbonyl compounds and condensations with some vic-polyones". ... 5-Hydroxy-2(5H)-furanone "2,4(3H,5H)-Furandione". Sigma-Aldrich. Abdou, Moaz M.; El-Saeed, Rasha A.; Abozeid, Mohamed A.; ... 12 (4): 464-475. doi:10.1016/j.arabjc.2015.11.004. Georgiadis, Dimitris; Zografos, Alexandros (2006). "Synthetic Strategies ...
https://en.wikipedia.org/wiki/Tetronic_acid
White-Chen catalystWhite-Chen catalyst
... acid directed diastereoselective lactonization of tetrahydrogibberellic acid via a C-H oxidation to form a butyrolactone ... 101 (4): 1032-1033. doi:10.1021/ja00498a040. Chen, Mark S.; White, M. Christina (2007). "A Predictably Selective Aliphatic C-H ...
https://en.wikipedia.org/wiki/White–Chen_catalyst
List of designer drugsList of designer drugs
... γ-Butyrolactone GHV, γ-Hydroxyvaleric acid (4-Methyl-GHB) GVL, γ-Valerolactone Afloqualone Etaqualone, 2-Ethylnormethaqualone ... 2C-B, "Siberia" 2C-B-AN, Brolphetaminil 2C-B-FLY 2C-C 2C-D, 2C-M 2C-E, "Europa" 2C-G 2C-iP, "Jelena" 2C-I 2C-P 2C-T-2 2C-T-4 2C ... 4'-Bromo-4-methylaminorex, 4'-B-4-MAR, 4B-MAR 4'-Chloro-4-methylaminorex, 4'-C-4-MAR, 4C-MAR 4'-Fluoro-4-methylaminorex, 4'-F-4 ... "4-methyl-N,N-DMC". Cayman Chemical. Retrieved 7 April 2015. Weiß JA, Taschwer M, Kunert O, Schmid MG (March 2015). "Analysis of ...
https://en.wikipedia.org/wiki/List_of_designer_drugs
Controlled Drugs and Substances ActControlled Drugs and Substances Act
... safrole Gamma-butyrolactone (dihydro-2(3H)-furanone) 1,4-butanediol Red Phosphorus White Phosphorus Hypophosphorous acid, its ... Section (4), Subsection (2) of the CDSA reads that any person who obtains or who makes any attempt to obtain a Schedule I ... 4-b)indole) and any salt thereof Harmalol (4,9-dihydro-1-methyl-3H-pyrido(3,4-b)indol-7-ol) and any salt thereof Psilocin (3-[2 ... 2-bromo-4-(o-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine) Camazepam (7-chloro-1,3-dihydro-3-(N,N- ...
https://en.wikipedia.org/wiki/Controlled_Drugs_and_Substances_Act
Iron(III) chlorideIron(III) chloride
This test can be used to detect the presence of gamma-hydroxybutyric acid and gamma-butyrolactone, which cause it to turn red- ... Zhang SY, Huang ZP (2006). "A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) ... Fe(H2O)6]3+ + 4 OH− → [Fe(OH)4(H2O)2]− + 4 H2O → [FeO(OH)2(H2O)]− + 6 H2O It is also used as a leaching agent in chloride ... FeCl3·3.5H2O has the structural formula cis-[FeCl2(H2O)4][FeCl4]·3H2O. hexahydrate: FeCl3·6H2O has the structural formula trans ...
https://en.wikipedia.org/wiki/Iron(III)_chloride
Glutaric acidGlutaric acid
... can be prepared by the ring-opening of butyrolactone with potassium cyanide to give the mixed potassium ... 4, p. 496 Peter Werle and Marcus Morawietz "Alcohols, Polyhydric" in Ullmann's Encyclopedia of Industrial Chemistry: 2002, ...
https://en.wikipedia.org/wiki/Glutaric_acid
Federal Analogue ActFederal Analogue Act
B) The designation of gamma butyrolactone or any other chemical as a listed chemical pursuant to paragraph (34) or (35) does ... However, a jury in Federal District Court in Chicago in a different case found 1,4-butanediol not to be an analog of GHB under ... It was raised in defense that 1,4-B and GHB contain different functional groups.[citation needed] but these were not held to be ... The controlled drug which it was alleged 1,4-B was substantially similar to was gamma-hydroxybutyrate (GHB). 1,4-B GHB In this ...
https://en.wikipedia.org/wiki/Federal_Analogue_Act
SKF-97,541SKF-97,541
Koek W, Mercer SL, Coop A (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone ( ... its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) ... 101 (4): 949-57. doi:10.1111/j.1476-5381.1990.tb14186.x. PMC 1917862. PMID 1964824. Jackson GL, Kuehl D (May 2002). "The GABA(B ...
https://en.wikipedia.org/wiki/SKF-97,541
Punctelia microstictaPunctelia microsticta
... a γ-butyrolactone acid from the lichen Punctelia microsticta". Journal of Natural Products. 62 (11): 1565-1567. doi:10.1021/ ... 113 (4): 728-738. doi:10.1639/0007-2745-113.4.728. Estraboua, Cecilia; Quiroga, Carolina; Rodríguez, Juan Manuel (2014). " ... doi:10.1007/s10661-011-1882-4. Rosato, V.G. (2003). "Lichens found on the bridge "La Postrera" across the Salado river, ...
https://en.wikipedia.org/wiki/Punctelia_microsticta
LactoneLactone
β-propiolactone γ-butyrolactone (GBL) D-glucono-δ-lactone (E575) ε-caprolactone Macrolides Kavalactones Ellagic acid ( ... butyrolactone, avermectins), antibiotics (macrolides like erythromycin; amphotericin B), anticancer drugs (vernolepin, ... γ-lactones are so stable that, in the presence of dilute acids at room temperature, 4-hydroxy acids (R-CH(OH)-(CH2)2-COOH) ... Therefore, the prefixes also indicate the size of the lactone ring: α-lactone = 3-membered ring, β-lactone = 4-membered, γ- ...
https://en.wikipedia.org/wiki/Lactone
Β-ButyrolactoneΒ-Butyrolactone
Entry from β-Butyrolactone from TCI Europe, retrieved on 20 December 2018 Sigma-Aldrich Co., β-Butyrolactone. H. Abe; I. ... According to an IARC classification, β-butyrolactone is assigned to group 2B: "possibly carcinogenic". (R)-β-butyrolactone ... in acetonitrile under microwave irradiation within 1h to β-butyrolactone (74% yield). β-Butyrolactone is a clear liquid that ... β-Butyrolactone is obtained in 63% yield by the addition of ethanal to ethenone (ketene) in the presence of the clay mineral ...
https://en.wikipedia.org/wiki/Β-Butyrolactone
Standard for the Uniform Scheduling of Medicines and PoisonsStandard for the Uniform Scheduling of Medicines and Poisons
gamma-Butyrolactone (excluding its derivatives) in non-polymerised form in preparations for domestic and cosmetic use. ... 2,4-Dinitrophenol for human use. Disperse Yellow 3 for use in hair dyes. Dulcin for therapeutic use. Ethylene glycol for use in ... cost of the drug is high, or when there is a risk of dependence The price of many Schedule 4 substances are subsidized by the ... 1,4-Butanediol (excluding its derivatives) in non-polymerised form in preparations for domestic use. Benzyl butyl phthalate for ...
https://en.wikipedia.org/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons
Fluorination by sulfur tetrafluorideFluorination by sulfur tetrafluoride
7) Fluorination of lactones can provide heterocyclic fluorides, although ring opening has been observed for γ-butyrolactone. ... 4) Sulfur tetrafluoride can be used to replace a variety of functional groups with partially or fully fluorinated derivatives. ...
https://en.wikipedia.org/wiki/Fluorination_by_sulfur_tetrafluoride
Adenosylmethionine cyclotransferaseAdenosylmethionine cyclotransferase
Mudd SH (July 1959). "The mechanism of the enzymatic cleavage of S-adenosylmethionine to alpha-amino-gamma-butyrolactone". The ... 2-aminobutan-4-olide Hence, this enzyme has one substrate, S-adenosyl-L-methionine, and two products, 5'-methylthioadenosine ... and 2-aminobutan-4-olide. This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl ...
https://en.wikipedia.org/wiki/Adenosylmethionine_cyclotransferase
TulipTulip
... alin A, or α-methylene-γ-butyrolactone, is a common allergen, generated by hydrolysis of the glucoside tuliposide A. It ... 4: Darwin hybrid - single flowers are ovoid in shape and up to 6 cm (2.5 inches) wide. Plants grow 50-70 cm (20-28 inches) tall ... Tulips should be planted 10 to 15 cm (4 to 6 inches) apart from each other. The recommended hole depth is 10 to 20 cm (4 to 8 ... 4 (3): 24-42. doi:10.2307/1586521. JSTOR 1586521. Tan, Dun-Yan; Zhang, Zhen; Li, Xin-Rong; Hong, De-Yuan (2005). "Restoration ...
https://en.wikipedia.org/wiki/Tulip
3-Dimethylaminoacrolein3-Dimethylaminoacrolein
... γ-butyrolactone) or cyclic ketones (such as cyclopentanone) form with the vinylamidinium salt of 3-dimethylaminoacrolein and ... 4-disubstituted thiophenes", Tetrahedron Lett., vol. 46, no. 8, pp. 1319-1320, doi:10.1016/j.tetlet.2004.12.113 EP 0372654, L. ... ISBN 978-81-317-3144-4 J.T. Zacharia; T. Tanaka; M. Hagashi (2010), "Facile and highly enenatioselective synthesis of (+)- and ...
https://en.wikipedia.org/wiki/3-Dimethylaminoacrolein
CynaropicrinCynaropicrin
Its γ-butyrolactone ring is involved in most of its biological functions. The unsaturated carbonyl group on the lactone ring ... 313 (4): 954-961. doi:10.1016/j.bbrc.2003.12.026. ISSN 0006-291X. PMID 14706635. Cho, Jae Youl; Kim, Ae Ra; Jung, Jee H.; Chun ... 70 (4): 441-453. doi:10.1007/s11130-015-0503-8. ISSN 1573-9104. PMID 26310198. S2CID 5345360. Suchý, M.; Herout, V.; Šorm, F. ( ... 90 (4): 1918-1930. doi:10.1128/JVI.02030-15. ISSN 1098-5514. PMC 4734011. PMID 26656684. Shimoda, Hiroshi; Ninomiya, Kiyofumi; ...
https://en.wikipedia.org/wiki/Cynaropicrin
Ann-Christine AlbertssonAnn-Christine Albertsson
... α-bromo-γ-butyrolactone, via selective organocatalysis". Polymer. Elsevier BV. 87: 17-25. doi:10.1016/j.polymer.2016.01.067. ... American Chemical Society (ACS). 4 (8): 4370-4377. doi:10.1021/acssuschemeng.6b00938. ISSN 2168-0485. Nugroho, Robertus Wahyu N ...
https://en.wikipedia.org/wiki/Ann-Christine_Albertsson
TryptopholTryptophol
... phenylethyl alcohol and gamma-butyrolactone, secondary products of alcoholic fermentation". Comptes Rendus de l'Académie des ... 251 (4): 907-13. doi:10.1016/S0021-9258(17)33779-1. PMID 2607. Laćan, G; Magnus, V; Jericević, B; Kunst, L; Iskrić, S (1984). " ... 76 (4): 889-93. doi:10.1104/pp.76.4.889. PMC 1064400. PMID 16663965. Cornford, Eain M.; Crane, Paul D.; Braun, Leon D.; Bocash ... 71 (4): 411-418. doi:10.1111/j.1399-3054.1987.tb02876.x. Richard Seed, John; Seed, Thomas M.; Sechelski, John (1978). "The ...
https://en.wikipedia.org/wiki/Tryptophol
Peroxymonophosphoric acidPeroxymonophosphoric acid
Oxidation of THF with peroxymonophosphoric acid gives γ-butyrolactone. Schmidlin, Julius; Massini, Paul (1910). " ... P 2 O 5 + 2 H 2 O 2 + H 2 O ⟶ 2 H 3 PO 5 {\displaystyle {\ce {P2O5 + 2H2O2 + H2O -> 2H3PO5}}} H 4 P 4 O 12 + 4 H 2 O 2 ⟶ 4 H 3 ... P2O8)4− + H2O + 4 H+ → H3PO5 + H3PO4 Peroxydiphosphoric acid is obtained when phosphoric acid is treated with fluorine or ... 4 (4): 552-558. doi:10.1021/ic50026a024. Ogata, Yoshiro; Tomizawa, Kohtaro; Ikeda, Toshiyuki (1979). "Oxidation of trans- ...
https://en.wikipedia.org/wiki/Peroxymonophosphoric_acid
Browsing by Subject 4-ButyrolactoneBrowsing by Subject "4-Butyrolactone"
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Browsing by Subject 4-ButyrolactoneBrowsing by Subject "4-Butyrolactone"
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CFR - Code of Federal Regulations Title 21
γ-butyrolactone; 4,4-dibutyl-4-hydroxy-butyric acid, γ-lactone. ... 4, 1980; 47 FR 27810, June 25, 1982; 48 FR 10812, Mar. 15, 1983; 48 FR 51907, Nov. 15, 1983; 49 FR 5747, Feb. 15, 1984; 50 FR ... Guaiene; 1,4-dimethyl-7-isopropenyl-[delta]9,10-octahydroazulene. Guaiol acetate; 1,4-dimethyl-7-([alpha]-hydroxy-isopropyl)-δ ... 4-Phenyl-2-butyl acetate; phenylethyl methyl carbinyl acetate. 1-Phenyl-3-methyl-3-pentanol; phenylethyl methyl ethyl carbinol ...
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=172&showFR=1&subpartNode=21:3.0.1.1.3.6
Isocarbophos|Isofenphos-methyl|Phoxim;Baythion;Volaton|Triazophos|DL-r-butyrolactone|3-Methyl-4-methythiophenol|Salicylic acid...
3-Methyl-4-methythiophenol,Salicylic Acid,Salicylic acid isopropyl ester,Methyl salicylate,Isoamylsalicylate,Phthalimide,N- ...
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Search ResultsSearch Results
Workplace Medical Mystery:Blurry vision affects a print press operator | Blogs | CDCWorkplace Medical Mystery:Blurry vision affects a print press operator | Blogs | CDC
butyrolactone. EGMEE. EGMEEA. ethylene glycol. n-hexane. toluene. trichoroethylene. triethylamine. Reply. Grady Holt says: ...
http://blogs.cdc.gov/niosh-science-blog/2015/03/16/medical-mystery1/
EAWAG-BBD: Compound Page, compID# c0033EAWAG-BBD: Compound Page, compID# c0033
EAWAG-BBD reactions whose substrate is Butyrolactone *Butyrolactone -----, 4-Hydroxybutanoate (reacID# r0016) [Tetrahydrofuran ... EAWAG-BBD reactions whose product is Butyrolactone *2-Hydroxytetrahydrofuran -----, Butyrolactone (reacID# r0018) * ... Butyrolactone. *Formula: C4H6O2. *MW: 86.09. *SMILES String: O=C1CCCO1. *Synonyms: 1,2-Butanolide; 1,4-Butanolide; 1,4- ... Alpha-Butyrolactone; BLO; BLON; Butyric acid lactone; Butyryl lactone; Butyrylactone; Dihydro-2(3H)-furanone; Dihyro-2-furanone ...
http://eawag-bbd.ethz.ch/servlets/pageservlet?ptype=c&compID=c0033
Adverse Events Associated with Ingestion of Gamma-Butyrolactone Minnesota, New Mexico, and Texas, 1998-1999Adverse Events Associated with Ingestion of Gamma-Butyrolactone Minnesota, New Mexico, and Texas, 1998-1999
Products containing gamma-butyrolactone (GBL) * are marketed for many claimed purposes, including to induce sleep, release ... FDA warns about products containing gamma butyrolactone or GBL and asks companies to issue a recall. Rockville, Maryland: US ... Rambourg-Schepens MO, Buffet M, Durak C, Mathieu-Nolf M. Gamma butyrolactone poisoning and its similarities to gamma ... Adverse Events Associated with Ingestion of Gamma-Butyrolactone Minnesota, New Mexico, and Texas, 1998-1999 ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00056563.htm
Withdrawal Syndromes Workup: Laboratory Studies, Imaging Studies, Other TestsWithdrawal Syndromes Workup: Laboratory Studies, Imaging Studies, Other Tests
Ghio L, Cervetti A, Respino M, Belvederi Murri M, Amore M. Management and treatment of gamma butyrolactone withdrawal syndrome ... Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review. CJEM. 2008 ...
https://www.medscape.com/answers/819502-79157/what-is-the-role-of-cardiac-markers-in-the-workup-of-withdrawal-syndrome
Michigan Public Health Code Section 333.7401a| Controlled Substance to Commit Criminal Sexual ConductMichigan Public Health Code Section 333.7401a| Controlled Substance to Commit Criminal Sexual Conduct
Delivery of a controlled substance or gamma-butyrolactone to commit criminal sexual conduct is a felony punishable by up to 20 ... Delivery of a controlled substance or gamma-butyrolactone (GBL) to commit criminal sexual conduct has four elements, all of ... For more information about delivery of a controlled substance or gamma-butyrolactone to commit criminal sexual conduct and to ... Michigan Public Health Code Section 7401a (MCL 333.7401a): Delivery of a Controlled Substance or Gamma-Butyrolactone to Commit ...
https://www.grabellaw.com/section-333-7401a.html
Withdrawal Syndromes Treatment & Management: Approach Considerations, Prehospital Care, Emergency Department CareWithdrawal Syndromes Treatment & Management: Approach Considerations, Prehospital Care, Emergency Department Care
Ghio L, Cervetti A, Respino M, Belvederi Murri M, Amore M. Management and treatment of gamma butyrolactone withdrawal syndrome ... Buprenorphine may be started at a dose of 2-4 mg and titrated to relief of the withdrawal syndrome. Buprenorphine is a partial ... The dosing is 1-4 mg every 5-15 minutes until adequate control of agitation is achieved. Large and rapid doses of lorazepam may ... At that point, the sedative can be tapered by decreasing the dose or lengthening the dosing interval over 3-4 days. ...
https://emedicine.medscape.com/article/819502-followup
Rhodium GHB Synthesis FAQRhodium GHB Synthesis FAQ
Q: Where can I buy butyrolactone/Is it safe to buy butyrolactone? A: I have no idea how the situation is for you in your ... Outlines of a purification of gamma-butyrolactone. US Pat No 4,851,085 Purification of gamma-butyrolactone to remove metal ions ... gamma-Butyrolactone (GBL). Dosage: 0.5-3ml Duration: 2-5 h Qualitative effects: Very similar to GHB. More muscle relaxing and ... gamma-Butyrolactone. Mol wt 86.09; mp -43.53 C; bp 204 C; d 1.12 g/ml CAS No: [96-48-0] Flash point: 98 C Miscible with water, ...
https://www.erowid.org/archive/rhodium/chemistry/ghb.html
KEGG COMPOUND: C01770
C01770 gamma-Butyrolactone. BRITE hierarchy. Other DBs. CAS: 96-48-0. PubChem: 4903. ... 4 O6a O 30.1000 -16.0300. 5 C1x C 26.9500 -17.7800. 6 C1x C 26.5300 -16.3800. BOND 6. 1 1 2 1. 2 1 3 1. 3 1 4 2. 4 2 5 1. 5 3 6 ...
https://www.genome.jp/entry/C01770
Wisconsin Legislature: 961.14(7)(L)17.Wisconsin Legislature: 961.14(7)(L)17.
961.14(5)(ag) (ag) Gamma-hydroxybutyric acid (commonly known as gamma hydroxybutyrate or "GHB"), gamma-butyrolactone, and 1,4- ... 1995 s. 961.14; 1997 a. 220; 1999 a. 21; 2001 a. 16; 2005 a. 52; 2011 a. 31; 2013 a. 267, 351; 2017 a. 4, 60, 100; 2017 a. 364 ... 961.14(7)(p) (p) 4-methylthioamphetamine, commonly known as "4-MTA." 961.14(7)(q) (q) N- benzylpiperazine, commonly known as " ... 961.14(7)(L)30. 30. N,N-diethyl-3,4-methylenedioxycathinone. 961.14(7)(L)31. 31. Alpha-methylamino-valerophenone, commonly ...
https://docs.legis.wisconsin.gov/statutes/statutes/961/ii/14/7/l/17
CN102603605B - Preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide - Google Patents
The method adopts ethyl (S)-4-halo-3-hydroxybutyrate and ethyl glycinate hydrochloride as main raw materials, which has the ... A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide comprises allowing reaction of ethyl glycinate hydrochloride ... and ethyl (S)-4-halo-3-hydroxybutyrate in alcohol solvent and alkaline conditions, filtering, washing, concentrating, ... disclosed method comprises from chiral beta-hydroxy butyrolactone acquisition chirality 3; 4-epoxy butyric ester; products ...
https://patents.google.com/patent/CN102603605B/en
Buy GBL (Gamma butyrolactone) Wheel Clea, transportation type: Open.Buy GBL (Gamma butyrolactone) Wheel Clea, transportation type: Open.
Buy GBL (Gamma butyrolactone) Wheel Cleaner and other related chemicals..Download Wickr me App and message me using my Wickr ID ... Buy GBL (Gamma butyrolactone) Wheel Clea HELLO, WE ALL SUPPLIERS OF ASSORTED PAIN KILLERS AND ANXIETYY PAIN Relief Meds, And ... Buy GBL (Gamma butyrolactone) Wheel Cleaner and other related chemicals... Download Wickr me App and message me using my Wickr ... Buy GBL (Gamma butyrolactone) Wheel Cleaner and other related chemicals. DBO Cosmetic GHB Corporation GHB-Shop Đai Viet TaiWan ...
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Palladium-mediated cyclizations of gamma-oxoallenes: synthesis of structurally modified nucleic acidsPalladium-mediated cyclizations of gamma-oxoallenes: synthesis of structurally modified nucleic acids
5-hexadienoic acid to give butyrolactone products will be described (see Scheme 1; R" = OH). ...
https://ttu-ir.tdl.org/handle/2346/15818?locale-attribute=es
gamma butyrolactone tci Archives - Hotchemsalesgamma butyrolactone tci Archives - Hotchemsales
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1,4 Butanediol Market Report 2018: Segmentation by Technology1,4 Butanediol Market Report 2018: Segmentation by Technology
4 Butanediol Market Report 2018 - 1,4 Butanediol Market Report 2018: Segmentation by Technology (Reppe process, Davy process, ... gamma-butyrolactone (GBL), polyurethane (PU), and other solvents. These chemicals are widely used in fibers, engineering ... Application of 1,4 Butanediol:. THF. PBT. GBL. PU. Others. Regions covered in 1,4 Butanediol Market Research Report: North ... 1,4 Butanediol, commonly known as BDO, is an organic compound predominantly used as a solvent in industrial cleaners and glue ...
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Florida Sale of a Controlled Substance Laws | CriminalDefenseLawyer.comFlorida Sale of a Controlled Substance Laws | CriminalDefenseLawyer.com
gamma-butyrolactone (GBL). *gamma-hydroxybutyric acid (GHB). *methaqualone, and. *mecloqualone.. Felony sale of the second ...
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DeCSDeCS
91(77); was see under FURANS 1977-90; was GAMMA BUTYROLACTONE see under FURANS 1976. ... 91; was see under FURANS 1977-90; was GAMMA BUTYROLACTONE see under FURANS 1976. ... 4-Butyrolactone - Preferred Concept UI. M0023238. Scope note. One of the FURANS with a carbonyl thereby forming a cyclic ... 4-Butyrolactone Entry term(s). 1,4 Butanolide 1,4-Butanolide 4 Butyrolactone 4 Hydroxybutyric Acid Lactone 4-Hydroxybutyric ...
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School of Chemistry - ThesesSchool of Chemistry - Theses
... γ-hydroxymethy-γ-butyrolactone. The synthesis highlights the application of a formal [2+2] cycloaddition and a remarkable acid- ... 2018, 20, 4255-4258). This key retron was prepared in 7 linear steps, requiring only 4 purification, with a 40% yield from (S ...
https://minerva-access.unimelb.edu.au/collections/422643e1-d379-578c-9c64-c7cacff7e6e1?spc.page=1&view=listElement&spc.sf=dc.date.available&spc.sd=DESC&f.author=Robertson,%20Angus,equals
LORAZEPAM
A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol.. 2001 Jul ...
https://drugs.ncats.io/drug/O26FZP769L
Find Research outputs - Montclair State University
5-trisubstituted γ-butyrolactone phospholipids. Li, X. & Rotella, D. P., 1 Mar 1994, In: Lipids. 29, 3, p. 211-224 14 p.. ... Synthesis of (L)-4-fluorotryptophan. Konas, D. W., Seci, D. & Tamimi, S., 1 Jan 2012, In: Synthetic Communications. 42, 1, p. ... Wu, Q., Zhu, M., Gu, Y. & Rao, N. S. V., 1 Apr 2010, In: IEEE Transactions on Parallel and Distributed Systems. 21, 4, p. 438- ... Yang, J. G. S. & Lauricella, L. J., 1 Jul 2010, In: Journal of Internet Commerce. 9, 3-4, p. 222-242 21 p.. Research output: ...
https://researchwith.montclair.edu/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&ordering=title&descending=false&page=139
IMSEAR at SEARO: Search
IMSEAR is the collaborative product of Health Literature, Library and Information Services (HELLIS) Network Member Libraries in the WHO South-East Asia Region ...
https://imsear.searo.who.int/handle/123456789/1365/simple-search?query=&sort_by=score&order=desc&rpp=10&filter_field_1=subject&filter_type_1=equals&filter_value_1=Animals&etal=0&filtername=author&filterquery=Ganu%2C+U+K&filtertype=equals
Esters, Alkanoates (Except Acetates): Chemical IdentificationEsters, Alkanoates (Except Acetates): Chemical Identification
b-BUTYROLACTONE. 3-Hydroxybutanoic acid, b-lactone; Hydroxybutyric acid lactone; 3-Hydroxybutyric acid lactone; 4-Methyl-2- ... 1,4-butanolide; Butyric acid, 4-hydroxy-, g-lactone; Butyrolactone; 4-Butyrolactone; Butyrylactone; Butyryl lactone; 2-(3H)- ...
https://www.iloencyclopaedia.org/part-xviii-10978/guide-to-chemicals/item/1123-esters-alkanoates-except-acetates-chemical-identification
DETHERM - Thermophysical Properties & Phase Equilibrium Data of Pure Substances & MixturesDETHERM - Thermophysical Properties & Phase Equilibrium Data of Pure Substances & Mixtures
γ-butyrolactone. *1,4-butyrolactone. *4-deoxytertanoic acid. *α-butyrolactone. *dehydro-2(3h)-furanone ...
https://i-systems.dechema.de/detherm/dbOverview.php?ID=4526
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens - StaffQuorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens - Staff
Keywords: 4-Butyrolactone; Anti-Bacterial Agents; Biofilms; Cystic Fibrosis; Humans; Pseudomonas Infections; Pseudomonas ...
https://biofilm.ku.dk/staff/?pure=en%2Fpublications%2Fquorumsensing-blockade-as-a-strategy-for-enhancing-host-defences-against-bacterial-pathogens
1H NMR Spectrum (FDB008075) - FooDB1H NMR Spectrum (FDB008075) - FooDB
This project is supported by the Canadian Institutes of Health Research, Canada Foundation for Innovation, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Canada, Genome Alberta, and Genome British Columbia, a not-for-profit organization that is leading Canadas national genomics strategy with $900 million in funding from the federal government ...
https://foodb.ca/spectra/nmr_one_d/10678
LactoneAcidIndustriallyControlled substanceSynthesisSodium hydroxideColorlessButanediol20222021CatalystProductsCompoundPurityLiquidChemicalSystematicSpecifications1998ChemicalsEthanolScopeMOPPPMephedroneMDMACommonly knownTypeOrderGoodPresenceAlcoholUsageReview
Lactone2
  • It may be slightly yellow colored, but not much if pure enough butyrolactone was used (distillation of the lactone before use takes care of this problem). (erowid.org)
  • It is the simplest 4-carbon lactone. (ukadslist.com)
Acid3
  • The base catalyzed reaction is our choice here, because the reaction is not reversible like the acid catalyzed one and therefore we will get higher yields, and we will get the sodium salt of GHB, as the free acid is not stable, and will immediately cyclize into gamma-butyrolactone again. (erowid.org)
  • 961.14(5)(ag) (ag) Gamma-hydroxybutyric acid (commonly known as gamma hydroxybutyrate or "GHB"), gamma-butyrolactone, and 1,4-butanediol. (wisconsin.gov)
  • There aren't many legal uses for 4-hydroxybutanoic acid. (ashwoodrecovery.com)
Industrially4
  • 1,4-Butanediol is used industrially as a solvent and in the production of certain types of plastics, elastic fibers and polyurethanes. (fabryka-detailingu.pl)
  • γ-Butyrolactone is produced industrially by dehydrogenation of 1,4-butanediol at a temperature of 180-300 °C and atmospheric pressure in the presence of a copper catalyst. (exsyncorp.com)
  • Delhydrogenation of 1,4-butanediol at 180-300 ° C, atmospheric pressure in the presence of copper catalyst, produces α-Butyrolactone industrially. (globalchemicalinc.com)
  • 1,4-Butanediol liquid is used industrially as a solvent and in the manufacture of some types of plastics , elastic fibers and polyurethanes. (whmulei.com)
Controlled substance3
  • Delivery of a controlled substance or gamma-butyrolactone to commit criminal sexual conduct is a felony punishable by up to 20 years in prison. (grabellaw.com)
  • For more information about delivery of a controlled substance or gamma-butyrolactone to commit criminal sexual conduct and to talk about your case, contact Grabel & Associates at (800) 342-7896. (grabellaw.com)
  • Relating to: the proper chemical name of the controlled substance gamma-butyrolactone (suggested as remedial legislation by the department of justice). (wisconsin.gov)
Synthesis2
  • In organic chemistry, 1,4-butanediol is used for the synthesis of γ-butyrolactone (GBL). (fabryka-detailingu.pl)
  • A catalytic method for synthesis of γ-butyrolactone, ε-caprolactone and 2-cumaranone in the presence of Preyssler's anion, [NaP5W30O110]14-, as a green and reusable catalyst. (edu.pl)
Sodium hydroxide3
  • All published preparations of GHB, or more correctly Na-GHB, refluxes butyrolactone with sodium hydroxide in various solvents, usually in aqueous alcohol, but this is not necessary. (erowid.org)
  • The addition of gamma-butyrolactone to the sodium hydroxide solution is also exothermic, and if it is added too fast the solution will begin to boil, and we don't want that. (erowid.org)
  • These include either GBL (gamma-butyrolactone) or BDO (1,4 butanediol) along with sodium hydroxide or potassium hydroxide. (theblackberrycenter.com)
Colorless3
  • Butyrolactone is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor. (ukadslist.com)
  • γ-Butyrolactone (GBL) is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor. (exsyncorp.com)
  • μ-Butyrolactone (GBL) is a colorless hygroscopic water-mixable fluid of low odour. (globalchemicalinc.com)
Butanediol14
  • Wojtowicz JM, Yarema MC, Wax PM. Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review. (medscape.com)
  • Global 1,4 Butanediol market research report provides company profile for BASF SE (Germany), Dairen Chemicals (Taiwan), LyondellBasell Chemicals (The Netherlands), Shanxi Sanwei Group (China), International Specialty Products (U.S.), Invista (U.S.), Mitsubishi Chemicals (Japan) and Others. (openpr.com)
  • 1,4 Butanediol, commonly known as BDO, is an organic compound predominantly used as a solvent in industrial cleaners and glue removers such as tetrahydrofuran (THF). (openpr.com)
  • The Global 1,4 Butanediol Market analysis report covers detailed value chain analysis of Global 1,4 Butanediol Market. (openpr.com)
  • The Global 1,4 Butanediol Market report explores manufacturer's competitive scenario and provides market share for all major players of this market based on production capacity, sales, revenue, geographical presence and other major factors. (openpr.com)
  • According to the Drug Enforcement Administration , GHB has a number of analogues known as GBL (gamma butyrolactone) and 1,4 BD (1,4-butanediol). (ashwoodrecovery.com)
  • However, there may be defenses, and you should not hesitate to find an experienced Bradenton 1,4-butanediol lawyer if you suspect you are being investigated for trading 1,4-butanediol. (fabryka-detailingu.pl)
  • Taking 1,4-butanediol with alcohol increases drowsiness and drowsiness caused by alcohol. (fabryka-detailingu.pl)
  • Do not take 1,4-butanediol if you have been drinking. (fabryka-detailingu.pl)
  • World production of 1,4-butanediol is expected to be about one million tonnes per year and the market price is around US€2,000 (€1,600) per tonne (2005). (fabryka-detailingu.pl)
  • 9] 1,4-Butanediol is also used as a recreational drug, known by some users as „One Comma Four", „Liquid Fantasy", „One Four Bee" or „One Four B-D-O". Some federal courts have found that 1,4-butanediol has similar effects to γ-hydroxybutyrate (GHB), which is a metabolite of 1,4-butanediol. (fabryka-detailingu.pl)
  • 1,4-Butanediol is converted by the body into another chemical called GHB. (fabryka-detailingu.pl)
  • Taking naloxone with 1,4-butanediol may reduce the effect of 1,4-butanediol and GHB on the brain. (fabryka-detailingu.pl)
  • Ritonavir may decrease how quickly the body gets rid of 1,4-butanediol. (fabryka-detailingu.pl)
20221
20212
  • The report gives the detailed overview of Global Gamma-Butyrolactone Market 2021 and predicts future market trends throughout 2027. (kaafweb.com)
  • The Global Gamma-Butyrolactone Market is poised to grow strongly throughout the forecast period 2021- 2027. (kaafweb.com)
Catalyst1
  • One pot catalytic syntheses of substituted 1,8-naphthyridines and 2 H -pyrano[3,2- g ]quinolin-2-ones by the reaction of α-ketoalkynes with 6-aminonicotinamide and 7-amino-4-methylcoumarin respectively in water, using a homogeneous nickel catalyst at very mild reaction conditions are described. (heterocycles.jp)
Products3
  • Products containing gamma-butyrolactone (GBL) * are marketed for many claimed purposes, including to induce sleep, release growth hormone, enhance sexual activity and athletic performance, relieve depression, and prolong life. (cdc.gov)
  • The prices at the online suppliers for purchasing gamma-Butyrolactone (GBL) Online or any other related products is reasonable and affordable by all. (globalchemicalinc.com)
  • A detailed analysis of the key industry players has been done to provide insights into their business overview, products and services, key strategies such as new product launches, mergers & acquisitions, partnerships, agreements, joint ventures, and recent developments associated with the Gamma-Butyrolactone market. (kaafweb.com)
Compound1
  • Goates J.R.: (Solid + liquid) phase equilibria and solid-compound formation in tetrachloromethane + cyclopentanone, + 4-butyrolactone, and + 1-methyl-2-pyrrolidinone. (ddbst.com)
Purity1
  • We are one of the world's top suppliers of the S-HGB (s)-3-Hydroxy-gamma-butyrolactone(Excellent purity, Highest Quality, and best Grade) available online in Australia and worldwide. (ads4uk.com)
Liquid1
  • Bylicki A.: (Solid + liquid) phase equilibria at atmospheric pressure for (N-methylpyrrolidin-2-one + 3,4-dimethylphenol). (ddbst.com)
Chemical2
  • It is an important intermediate chemical for tetrahydrofuran and polytetramethylene ether glycol (PTMEG), polybutylene terephthalate (PBT), gamma-butyrolactone (GBL), polyurethane (PU), and other solvents. (openpr.com)
  • With Global Chemical Inc you can order gamma-Butyrolactone (GBL) online at good rates and also at convenient responsive delivery service. (globalchemicalinc.com)
Systematic1
  • The effectiveness of lorazepam in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. (ncats.io)
Specifications1
  • The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. (lookchem.com)
19983
  • On November 26, 1998, a 24-year-old man vomited and had seizures shortly after drinking 3-4 oz of Revivarant. (cdc.gov)
  • On October 31, 1998, a 24-year-old man (patient 4) and a 26-year-old man (patient 5) each drank 10-13 oz of Revivarant while drinking alcohol at a bar. (cdc.gov)
  • 1998 Dec. 52(12):772-4. (medscape.com)
Chemicals1
  • Buy GBL (Gamma butyrolactone) Wheel Cleaner and other related chemicals. (collectioncar.com)
Ethanol1
  • Breath ethanol levels were 0.09% (patient 4) and 0.15% (patient 5). (cdc.gov)
Scope1
  • The scope of the report covers detailed information regarding the major factors influencing the growth of the Gamma-Butyrolactone market such as drivers, restraints, challenges, and opportunities. (kaafweb.com)
MOPPP1
  • 5. 4-methoxy-alpha-pyrrolidinopropiophenone, commonly known as MOPPP. (wisconsin.gov)
Mephedrone1
  • 3. 4-methylmethcathinone, commonly known as mephedrone or 4-MMC. (wisconsin.gov)
MDMA1
  • 11. 3,4-methylenedioxymethcathinone, commonly known as methylone or bk-MDMA. (wisconsin.gov)
Commonly known12
  • 4. 4-methylethcathinone, commonly known as 4-MEC. (wisconsin.gov)
  • 6. 3,4-methylenedioxy-alpha-pyrrolidinopropiophenone, commonly known as MDPPP. (wisconsin.gov)
  • 10. 4-fluoromethcathinone, commonly known as 4-FMC or flephedrone. (wisconsin.gov)
  • 13. 4-methyl-alpha-pyrrolidinobutiophenone, commonly known as MPBP. (wisconsin.gov)
  • 14. 4-methoxymethcathinone, commonly known as methedrone or bk-PMMA. (wisconsin.gov)
  • 16. 3,4-methylenedioxyethcathinone, commonly known as ethylone or bk-MDEA. (wisconsin.gov)
  • 21. 4-ethylmethcathinone, commonly known as 4-EMC. (wisconsin.gov)
  • 25. 4-bromomethcathinone, commonly known as 4-BMC. (wisconsin.gov)
  • 27. 3,4-methylenedioxy-alpha-pyrrolidinobutiophenone, commonly known as MDPBP. (wisconsin.gov)
  • 28. 4-methyl-alpha-pyrrolidinohexiophenone, commonly known as MPHP. (wisconsin.gov)
  • 32. 4-methyl-alpha-pyrrolidinopropiophenone, commonly known as 4-MePPP. (wisconsin.gov)
  • 37. 4-methyl-alpha-ethylainopentiophenone, commonly known as 4-MEAP. (wisconsin.gov)
Type1
  • Buy GBL (Gamma butyrolactone) Wheel Clea, transportation type: Open. (collectioncar.com)
Order5
  • You can order gamma-Butyrolactone (GBL) online as a wheel cleaner, paint cleaner and you can also order gamma-Butyrolactone (GBL) for industrial use. (globalchemicalinc.com)
  • So you can see how easy it is with us to order gamma-Butyrolactone (GBL) cleaner online. (globalchemicalinc.com)
  • You can order GBL gamma-Butyrolactone (GBL) Online to USA, Europe and why not world wide. (globalchemicalinc.com)
  • You can easily contact an online store using your devices right at your place and order gamma-Butyrolactone (GBL) Online. (globalchemicalinc.com)
  • There is no need to travel anywhere anymore you can always order gamma-Butyrolactone (GBL) online with us. (globalchemicalinc.com)
Good1
  • When everything has dissolved to form a clear solution, slowly add 250ml (280 g, 3.25 moles) of gamma-butyrolactone in 50 ml portions with good stirring. (erowid.org)
Presence1
  • At about 200 °C in the presence of soluble ruthenium catelysts, the diol undergoes dehyrogenation to form butyrolactone. (whmulei.com)
Alcohol1
  • BDO is a saturated carbon-4 straight-chain dibasic alcohol. (openpr.com)
Usage1
  • Some of the distinguished trends that the market is witnessing include regulatory restrictions, the growing usage of Gamma-Butyrolactone in several end user segments, recent technological developments of the industry and growth investment opportunities. (kaafweb.com)
Review1
  • Ghio L, Cervetti A, Respino M, Belvederi Murri M, Amore M. Management and treatment of gamma butyrolactone withdrawal syndrome: a case report and review. (medscape.com)
Search Results
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